CN108888581A - A kind of transdermal absorbing composition and its application - Google Patents
A kind of transdermal absorbing composition and its application Download PDFInfo
- Publication number
- CN108888581A CN108888581A CN201810860029.5A CN201810860029A CN108888581A CN 108888581 A CN108888581 A CN 108888581A CN 201810860029 A CN201810860029 A CN 201810860029A CN 108888581 A CN108888581 A CN 108888581A
- Authority
- CN
- China
- Prior art keywords
- absorbing composition
- transdermal absorbing
- transdermal
- acid
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of transdermal absorbing composition and its applications, this kind of transdermal absorbing composition is made of surfactant, amino acid, plant extracts, carbohydrate, solvent, and surfactant is selected from one of octanol, polysorbate40, polysorbate60, Tween 80, span 85, oleic acid, lauryl sulfosuccinic acid monoester disodium, single Tryfac 5573, Monododecylphosphate potassium, azone, soy phosphatidylcholine, neopelex, sodium glycocholate or a variety of；Amino acid is selected from one of arginine, alanine, methionine, glutamic acid, isoleucine, glycine, methionine or a variety of.Transdermal absorbing composition of the invention, hence it is evident that reduce the dosage of active material, while having the function of certain antibacterial, anti-inflammatory, detumescence；And can realize that local skin absorbs in a short time, have the characteristics that rapid-action, effect by force and it is lasting, penetration power is strong.
Description
Technical field
The invention belongs to medicine, cosmetic technical field, and in particular to a kind of transdermal absorbing composition and its application.
Background technique
It as society develops rapidly, lives more and more plentiful, the hope that people pursue beauty is also more more and more intense, especially
It is especially prominent for the aesthetic nursing demand of fleshy exterior.Skin aesthetic nursing means are mostly application class product, but due to the speed of absorption
Degree and degree are all restricted, so that the effect of aesthetic nursing is barely satisfactory.
Existing application class product can not or seldom penetrate skin barrier, can not play effective aesthetic nursing.Conversely,
Not by the material buildup of percutaneous absorption in skin appearance, the skin problem such as clogging of pores is easily led to, and induces inflammation.
Conventional application class product, Time of Administration 15-20min, the active constituent overwhelming majority cannot be absorbed, bioavilability
It is lower, real nursing role can not be played；Extend the application time, though uptake can be increased to a certain extent, for a long time
Attachment, easily cause fleshy exterior loss of moist and microorganism invasion.
Summary of the invention
It is an object of the invention to bad for existing application class skin beauty care product assimilation effect, active constituent is raw
The low insufficient defect of object availability provides a kind of transdermal absorbing composition and its application.
Present invention firstly provides a kind of transdermal absorbing compositions, can accelerate active material and penetrate the speed of skin without right
Skin forms stimulation and damage, and transdermal absorbing composition is substantially reduced the dosage of active material, while having certain antibacterial, disappearing
Scorching, detumescence effect.This transdermal absorbing composition can realize that local skin absorbs in a short time, have rapid-action, effect
The features such as lasting, penetration power is strong by force.
The present invention also provides a kind of application of transdermal absorbing composition in application class cosmetics, the Transdermal absorption groups
The mechanism of action for closing object is mainly penetrated into skin by reversible change skin texture or property and reduces active material
By resistance suffered by skin, achieve the purpose that the absorption or local treatment that promote active material.
Transdermal absorbing composition of the present invention contains various ingredients, and the action principle of each component is as follows：
Propylene glycol：Infiltration cuticula simultaneously forms accumulation wherein, increases dissolubility of the active material in cuticula and divides
With property；
Ethyl alcohol：It penetrates into cuticula and forms accumulation wherein, increase dissolubility and distribution of the active material in cuticula
Property；
Oleic acid：Horny layer of epidermis intercellular lipid is acted on, keeps corneocyte loose, iuntercellular is away from increase；
Azone：Horny layer of epidermis intercellular lipid is acted on, keeps corneocyte loose, iuntercellular is away from increase；With cell
Interior matrix phase separation, causes basal stratum corneum swelling, increases the degree of hydration of horn cell and the storage space of active material；
Hair follicle is acted on, keeps the cutin near follicular orifice loose, with the extension of action time, loose cutin falls off, and leads to hair follicle
Oral pore diameter is widened, and permeates active material through hair follicle approach；
Tetradecanol：Horny layer of epidermis intercellular lipid is acted on, keeps corneocyte loose, iuntercellular is away from increase；
Octanoic acid：Horny layer of epidermis intercellular lipid is acted on, keeps corneocyte loose, iuntercellular is away from increase；
Eucalyptus oil：The keratin for acting on cuticula makes the configuration of keratin change, relaxation they binding force so that
Fine duct is formed, to improve polar substances to the permeability of cell internal channel, promotes Transdermal absorption；
Polyethylene glycol：It influences iuntercellular to reveal, enhances the cell bypass transhipment of active material；
Soy phosphatidylcholine：Lipid between dissolution epithelial cell；
Neopelex：Act on horny layer of epidermis intercellular lipid, keep corneocyte loose, iuntercellular away from
Increase；
Sodium glycocholate：Lipid between dissolution epithelial cell
Arginine：Change the structure of keratinocyte, there is the effect of cell-penetrating peptide sample；
Alanine：Change the structure of keratinocyte, there is the effect of cell-penetrating peptide sample；
Methionine：Change the structure of keratinocyte, there is the effect of cell-penetrating peptide sample；
Cyclodextrin：Increase solubility and mucous membrane permeability；
Licorice：Keratoderma is acted on, space between cells is increased；
Pepper extract：Keratoderma is acted on, space between cells is increased；
Borneol：Change cutaneous permeability；
Peppermint：Change cutaneous permeability；
Borneol：Change cutaneous permeability.
To achieve the above object, the present invention uses following technical scheme：
The first aspect of the invention is to provide a kind of transdermal absorbing composition, and the transdermal absorbing composition is lived by surface
Property agent, amino acid, plant extracts, carbohydrate, solvent composition.
Further, in the transdermal absorbing composition, the surfactant is selected from octanol, polysorbate40, tween
60, Tween 80, span 85, oleic acid, lauryl sulfosuccinic acid monoester disodium, single Tryfac 5573, onodoidecyl phosphonic acid
One of ester potassium, azone, soy phosphatidylcholine, neopelex, sodium glycocholate are a variety of.
It is further preferred that the surfactant is by oleic acid, azone, soybean in the transdermal absorbing composition
Phosphatidyl choline, neopelex, sodium glycocholate composition.
Further, in the transdermal absorbing composition, the amino acid be selected from arginine, alanine, methionine,
One of glutamic acid, isoleucine, glycine, methionine are a variety of.
It is further preferred that the amino acid is by arginine, alanine, egg ammonia in the transdermal absorbing composition
Acid composition.
Further, in the transdermal absorbing composition, the plant extracts be selected from eucalyptus oil, licorice,
One of pepper extract, borneol, peppermint, borneol, Moschus, the achene of Siberian cocklebur, wrinkled giant hyssop are a variety of.
It is further preferred that the plant extracts is extracted by eucalyptus oil, Radix Glycyrrhizae in the transdermal absorbing composition
Object, pepper extract, borneol, peppermint, borneol composition.
Further, in the transdermal absorbing composition, the carbohydrate is in cyclodextrin, starch, glucan
It is one or more.
It is further preferred that the carbohydrate is cyclodextrin in the transdermal absorbing composition.
Further, in the transdermal absorbing composition, the solvent is selected from glycerine, water, butanediol, the third two
One of alcohol, ethyl alcohol, tetradecanol, hexadecanol, octadecyl alcolol, octanoic acid, polyethylene glycol are a variety of.
It is further preferred that the solvent is by water, propylene glycol, ethyl alcohol, the tetradecane in the transdermal absorbing composition
Alcohol, octanoic acid, polyethylene glycol composition.
Further, in the transdermal absorbing composition, the transdermal absorbing composition by water, propylene glycol, ethyl alcohol,
Oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, neopelex, glycocholic acid
Sodium, arginine, alanine, methionine, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol composition.
Further, in the transdermal absorbing composition, the transdermal absorbing composition by mass percentage, respectively
Component proportion is 0.01~90：0.01~30：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01
~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：
0.01~10：0.01~10：0.01~10.
It is further preferred that in the transdermal absorbing composition, the transdermal absorbing composition by water, propylene glycol,
Ethyl alcohol, oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, arginine, alanine, egg ammonia
Acid, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol composition, each group distribution ratio is by mass percentage
0.01~90：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01
~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：
0.01~10：0.01~10.
It is further preferred that in the transdermal absorbing composition, the transdermal absorbing composition is by water, the third two
Alcohol, ethyl alcohol, oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, arginine, alanine, egg
Propylhomoserin, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol form, by mass percentage each group distribution ratio
It is 0.01~90：0.01~10：0.01~10：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：
0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01
~5.
Further, in the transdermal absorbing composition, the pH value of the transdermal absorbing composition is 4.5~8.5.
It is further preferred that in the transdermal absorbing composition, the pH value of the transdermal absorbing composition is 5.0~
8.0。
Further, in the transdermal absorbing composition, the pH value of the transdermal absorbing composition is 7.2~7.6.
The second aspect of the invention is to provide a kind of above-mentioned transdermal absorbing composition in application class medical instrument, cosmetics
In application.
Transdermal absorbing composition of the invention, biocompatibility is excellent, and compatibility is high, and skin is covered on as light water
Surface, action component therein can promote active constituent transdermal penetration and enter surface skin.Noninvasive administration may be implemented, and be administered
Process has good selectivity, and the saturating effect of local skin rush for treating aesthetic nursing is good.Comprehensively consider, transdermal suction of the invention
Receive composition can according to the difference of aesthetic nursing type, adjust usage amount, can efficiently, accurately carry out promoting, avoid
The shortcomings that conventional application class product is not easy Transdermal absorption, the waste for avoiding material and deposit induce the risk of inflammation.
The present invention by adopting the above technical scheme, compared with prior art, has the following technical effect that：
1) transdermal absorbing composition of the invention can accelerate active material and penetrate the speed of skin without being formed to skin
Stimulation and damage.Transdermal absorbing composition is substantially reduced the dosage of active material, while having certain antibacterial, anti-inflammatory, detumescence
Effect.This transdermal absorbing composition can realize that local skin absorbs in a short time, and there is rapid-action, effect to hold by force
Long, the features such as penetration power is strong；
2) mechanism of action of transdermal absorbing composition of the invention mainly passes through reversible change skin texture or property
Pass through resistance suffered by skin to penetrate into skin and reduce active material, reaches the absorption or local treatment for promoting active material
Purpose.
Detailed description of the invention
Fig. 1 is the experimental data of Transdermal absorption effect of the present invention verifying.
Specific embodiment
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention,
But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Embodiment 2
Embodiment 3
Embodiment 4
Embodiment 5
Embodiment 6
Study on Biocompatibility
Experimental material and instrument：Transdermal absorbing composition (embodiment 6), cavy 6, animal razor.
Experimental method：Cavy is dispelled hair, and transdermal absorbing composition is coated on guinea pig back and abdomen, before coating (0min) and
5 after coating, 15,30,60,120, using position, whether there is or not red and swollen, damaged for 240min observation.
Experimental result：
Note："×" indicates "None", " √ " expression " having ".
Conclusion：Experiment shows that the transdermal absorbing composition biocompatibility in the present invention is excellent, has no adverse reaction substantially.
The verifying of Transdermal absorption effect
Experimental material and instrument：Transdermal absorbing composition (embodiment 6), collagen, Sodium Hyaluronate, vitamin C, life
It manages salt water, rat 24, animal razor, operating scissors, surgical forceps transdermal diffusion apparatus, Transdermal diffusion cell, UV, visible light and is divided light
Degree meter.
Experimental method：Rat is dispelled hair, and clip skin of back is placed in Transdermal diffusion cell, and sample cell is separately added into following sample,
Using physiological saline as acceptable solution, every group parallel 3 parts, transdermal diffusion experiment is carried out, in 10,30min sample detection, absorption value is taken
Average value, investigates Transdermal absorption effect, and experimental result is as shown in Figure 1：
Experimental result：
Collagen, Sodium Hyaluronate, vitamin C Transdermal absorption can be improved in transdermal absorbing composition in the present invention
The bioavilability of active material can be improved in speed and degree.
Conclusion：Experiment shows transdermal absorbing composition provided by the invention, can accelerate the speed that active material penetrates skin
Degree, can obviously reduce the dosage of active material, can realize that local skin absorbs in a short time, have rapid-action, effect by force
And the features such as lasting, penetration power is strong.
Specific embodiments of the present invention are described in detail above, but it is merely an example, the present invention is simultaneously unlimited
It is formed on particular embodiments described above.To those skilled in the art, any couple of present invention carries out equivalent modifications and
Substitution is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and
Modification, all should be contained within the scope of the invention.
Claims (17)
1. a kind of transdermal absorbing composition, which is characterized in that the transdermal absorbing composition is by surfactant, amino acid, plant
Object extract, carbohydrate, solvent composition.
2. transdermal absorbing composition according to claim 1, which is characterized in that the surfactant is selected from octanol, spits
Temperature 40, polysorbate60, Tween 80, span 85, oleic acid, lauryl sulfosuccinic acid monoester disodium, single Tryfac 5573, single 12
One of alkyl phosphate potassium, azone, soy phosphatidylcholine, neopelex, sodium glycocholate are a variety of.
3. transdermal absorbing composition according to claim 2, which is characterized in that the surfactant by oleic acid, azone,
Soy phosphatidylcholine, neopelex, sodium glycocholate composition.
4. transdermal absorbing composition according to claim 1, which is characterized in that the amino acid is selected from arginine, the third ammonia
One of acid, methionine, glutamic acid, isoleucine, glycine, methionine are a variety of.
5. transdermal absorbing composition according to claim 4, which is characterized in that the amino acid by arginine, alanine,
Methionine composition.
6. transdermal absorbing composition according to claim 1, which is characterized in that the plant extracts is selected from eucalyptus oil, sweet
One of careless extract, pepper extract, borneol, peppermint, borneol, Moschus, the achene of Siberian cocklebur, wrinkled giant hyssop are a variety of.
7. transdermal absorbing composition according to claim 6, which is characterized in that the plant extracts is by eucalyptus oil, Radix Glycyrrhizae
Extract, pepper extract, borneol, peppermint, borneol composition.
8. transdermal absorbing composition according to claim 1, which is characterized in that the carbohydrate is selected from cyclodextrin, starch, Portugal
One of glycan is a variety of.
9. transdermal absorbing composition according to claim 8, which is characterized in that the carbohydrate is cyclodextrin.
10. transdermal absorbing composition according to claim 1, which is characterized in that the solvent is selected from glycerine, water, fourth
One of glycol, propylene glycol, ethyl alcohol, tetradecanol, hexadecanol, octadecyl alcolol, octanoic acid, polyethylene glycol are a variety of.
11. transdermal absorbing composition according to claim 10, which is characterized in that the solvent is by water, propylene glycol, second
Alcohol, tetradecanol, octanoic acid, polyethylene glycol composition.
12. transdermal absorbing composition according to claim 1, which is characterized in that the transdermal absorbing composition is by water, third
Glycol, ethyl alcohol, oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, dodecyl benzene sulfonic acid
Sodium, sodium glycocholate, arginine, alanine, methionine, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol
Composition.
13. transdermal absorbing composition according to claim 12, which is characterized in that the transdermal absorbing composition presses quality
Percentages, each group distribution ratio are 0.01~90：0.01~30：0.01~10：0.01~10：0.01~10：0.01~10：
0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01
~10：0.01~10：0.01~10：0.01~10：0.01~10.
14. transdermal absorbing composition according to claim 13, which is characterized in that the transdermal absorbing composition by water,
Propylene glycol, ethyl alcohol, oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, arginine, the third ammonia
Acid, methionine, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol form, by mass percentage each group
Distribution ratio is 0.01~90：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~
10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：0.01~10：
0.01~10：0.01~10：0.01~10.
15. transdermal absorbing composition according to claim 14, which is characterized in that the transdermal absorbing composition by water,
Propylene glycol, ethyl alcohol, oleic acid, azone, tetradecanol, octanoic acid, eucalyptus oil, polyethylene glycol, soy phosphatidylcholine, arginine, the third ammonia
Acid, methionine, cyclodextrin, licorice, pepper extract, borneol, peppermint, borneol form, by mass percentage each group
Distribution ratio is 0.01~90：0.01~10：0.01~10：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：
0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01~5：0.01
~5：0.01~5.
16. transdermal absorbing composition according to claim 1, which is characterized in that the pH value of the transdermal absorbing composition
It is 4.5~8.5.
17. a kind of if the described in any item transdermal absorbing compositions of claim 1-16 are in application class medical instrument, cosmetics
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810860029.5A CN108888581A (en) | 2018-08-01 | 2018-08-01 | A kind of transdermal absorbing composition and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810860029.5A CN108888581A (en) | 2018-08-01 | 2018-08-01 | A kind of transdermal absorbing composition and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108888581A true CN108888581A (en) | 2018-11-27 |
Family
ID=64352951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810860029.5A Pending CN108888581A (en) | 2018-08-01 | 2018-08-01 | A kind of transdermal absorbing composition and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108888581A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812688A (en) * | 2019-11-20 | 2020-02-21 | 广州中医药大学(广州中医药研究院) | Transdermal drug delivery microneedle and preparation method thereof |
| CN114917158A (en) * | 2022-05-25 | 2022-08-19 | 云南西草资源开发有限公司 | Anti-aging essence containing micro-molecule plukenetia volubilis linneo oil with permeation promoting technology and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579276A (en) * | 2012-03-28 | 2012-07-18 | 湖北美林药业有限公司 | Permeation-promoting combination for cosmetic |
| CN108210419A (en) * | 2018-03-13 | 2018-06-29 | 佛山市汇汾化妆品科技有限公司 | A kind of rush penetrative composition |
-
2018
- 2018-08-01 CN CN201810860029.5A patent/CN108888581A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579276A (en) * | 2012-03-28 | 2012-07-18 | 湖北美林药业有限公司 | Permeation-promoting combination for cosmetic |
| CN108210419A (en) * | 2018-03-13 | 2018-06-29 | 佛山市汇汾化妆品科技有限公司 | A kind of rush penetrative composition |
Non-Patent Citations (1)
| Title |
|---|
| 王晖等: "含薄荷醇的复合促透剂促进盐酸氯丙嗪经皮吸收", 《中国现代应用药学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812688A (en) * | 2019-11-20 | 2020-02-21 | 广州中医药大学(广州中医药研究院) | Transdermal drug delivery microneedle and preparation method thereof |
| CN114917158A (en) * | 2022-05-25 | 2022-08-19 | 云南西草资源开发有限公司 | Anti-aging essence containing micro-molecule plukenetia volubilis linneo oil with permeation promoting technology and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2856480T3 (en) | Cosmetic uses of swertiamarin | |
| US20050232953A1 (en) | Microemulsions having a binary phase differentiability and active substance differentiability, the production thereof and their use, particularly for the topical supply of oxygen | |
| KR102195005B1 (en) | Liposome composition containing hyaluronic acid | |
| EP2552413B1 (en) | Novel support system for the transport of active substances into the skin | |
| TW201113046A (en) | Cosmetic base comprising collagen-modified liposome and skin cosmetic containing the same | |
| KR101895038B1 (en) | Dissolvable film comprising spicule and use thereof | |
| CN110664689A (en) | Eye cream preparation with flexible nano-liposome as carrier and preparation method thereof | |
| CN108888581A (en) | A kind of transdermal absorbing composition and its application | |
| CN110960458A (en) | Moisturizing essence emulsion and preparation method thereof | |
| CN100528127C (en) | Nanometer skin-activating emulsion cosmetics and its preparation process | |
| CN108379215A (en) | A kind of cosmetic composition for having effects that the freeze-drying compound powder of skin whitening and including the freeze-drying compound powder | |
| ITMI20111806A1 (en) | COMPOSITION FOR THE TREATMENT OF SKIN LESIONS | |
| KR20040101588A (en) | Cosmetic Compostion for Preventing Skin Aging Comprising Plant Extract as Oriental Medicine Stabilized in Nanoliposome | |
| KR101895037B1 (en) | Hydrogel comprising spicule and use thereof | |
| CN113350221A (en) | A skin care composition for resisting aging and its preparation method | |
| WO2014094377A1 (en) | Bee venom composition with effects of protecting and beautifying lip | |
| JP7039178B2 (en) | Topical composition containing crosslinked glycosaminoglycan | |
| CN111432778B (en) | Cochleates utilizing phosphatidylserine/anionic surfactant/calcium chloride | |
| FR3018449A1 (en) | COSMETIC USE OF A MIRABILIS JALAPA EXTRACT, ACTIVE INGREDIENT AND CORRESPONDING COSMETIC COMPOSITION | |
| Sun et al. | The preparation of high minoxidil loaded transfersomes and its gel for effective topical treatment of alopecia | |
| KR20210040522A (en) | Cosmetic composition, cosmetic mask pack comprisint the same and preperation method of the cosmetic composition | |
| KR101446706B1 (en) | Composition for skin rejuvenation comprising FGF | |
| KR102219317B1 (en) | A method of producing a cosmetic composition comprising a micelle complex formed by using natural moisturizing factor, and a cosmetic composition formed by the method | |
| KR102165566B1 (en) | Cosmetic composition with excellent skin elasticity | |
| JP2007045808A (en) | Skin care preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181127 |