CN108201134A - A kind of meals health-care drug and preparation method thereof - Google Patents
A kind of meals health-care drug and preparation method thereof Download PDFInfo
- Publication number
- CN108201134A CN108201134A CN201711316550.4A CN201711316550A CN108201134A CN 108201134 A CN108201134 A CN 108201134A CN 201711316550 A CN201711316550 A CN 201711316550A CN 108201134 A CN108201134 A CN 108201134A
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- CN
- China
- Prior art keywords
- health
- care drug
- preparation
- meals
- meals health
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- 239000003814 drug Substances 0.000 title claims abstract description 87
- 229940079593 drug Drugs 0.000 title claims abstract description 69
- 235000012054 meals Nutrition 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 238000002156 mixing Methods 0.000 claims abstract description 46
- 239000000284 extract Substances 0.000 claims abstract description 41
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 32
- 235000020985 whole grains Nutrition 0.000 claims abstract description 29
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 24
- 238000000605 extraction Methods 0.000 claims abstract description 23
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 6
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 6
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- 229910052742 iron Inorganic materials 0.000 description 12
- 229910052749 magnesium Inorganic materials 0.000 description 12
- 239000011777 magnesium Substances 0.000 description 12
- 229940091250 magnesium supplement Drugs 0.000 description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of meals health-care drugs and preparation method thereof, belong to field of medicaments, including following preparation process：The extraction of Chinese medicine, the extraction of adjuvant, the preparation of Chinese medical extract, batch mixing, granulation, curing, whole grain and packaging, and including raw material：Tea oil, Polysorbate 80, maltodextrin, magnesium stearate, Chinese medical extract, rice flour, vitamin D, lucidum spore powder, starch and calcium carbonate.Often drug effect is not high, side effect is larger etc. that technical problems are improved for existing meals health-care drug by the present invention, this meals health-care drug can not only provide the various nutrients of needed by human body, but also rich in enough unrighted acids, dosage used is suitable for the dietary of vast Chinese population.Body aging symptom can effectively be alleviated, cell viability is improved, boost metabolism.And the health medicine preparation method is simple, production cost is low.
Description
Technical field
The present invention relates to health care medicinal fields more particularly to a kind of meals health-care drug and preparation method thereof.
Background technology
With progress of the epoch, the improvement of people's quality of life, more and more crowds have begun to focus on healthy diet,
Modern research shows that sugar, lipid and protein in people's three meals in a day, energy is generated in cell mitochondrial through biological oxidation
(ATP) for the energy demand of all physiology of body and biochemical activity.The mistake that sugar, lipid, protein metabolism are aoxidized in the cell
The oxygen absorbed from air is constantly consumed in journey, biological oxidation is used in mitochondria into intracellular oxygen 90%, but still is had
1% to 4% oxygen is converted into oxygen radical, this thing most easy damaged mitochondrial DNA, so as to generate mitochondrial DNA simultaneously
The missing of segment influences the function of mitochondria, can not supply nutrition to human body.Oxygen radical has toxicity, has to cell ageing
Profound influence, brings the long-term surviving of cell adverse effect, and oxygen radical causes DNA damage to be the important of influence ageing process
Factor.Quite a few people, which both knows about appropriateness diet, can extend the service life, and people eats much, and mitochondria load is with regard to more, oxygen radical
It will largely generate, it is just big on mitochondrial function influence, so as to cause the aging of human body.
Unrighted acid is a kind of aliphatic acid for forming body fat, is aliphatic acid needed by human.It is understood that people
Internal oxygen radical has oxidisability, and cell senescence can be caused so as to cause a system such as human senility in long-term existence human body
Row symptom.And unrighted acid contains unsaturated bond, after digestive system, so as to be absorbed by human body；Unsaturated fat
Acid can be reacted with the oxygen radical in human body, and so as to reduce the oxygen radical in human body, long-term consumption can play alleviation
The effect of aging.But edible excess fat acid oil can cause grease excessive again, lead to the illnesss such as body diarrhea；How could
Obtain it is a kind of can supplement needed by human body nutrient and can alleviate the health medicine of body aging again become and social close extensively
The topic of note.Existing market health products have been dazzling, are all mostly to be rich in multi-nutrient element, although some
Health medicine can alleviate body aging to a certain extent, but its side effect is also what be should not be underestimated, easily be made after edible
Adult body overnutrition, the diseases such as hyperlipidemia, hyperglycemia are also to emerge in an endless stream.
The present invention is directed to the deficiency of existing health medicine, provides a kind of meals health-care drug.This meals health-care drug is not
The various nutrients of needed by human body are only capable of providing, but also rich in enough unrighted acids, dosage used is suitable for
The dietary of vast Chinese population.Body aging symptom can effectively be alleviated, cell viability is improved, boost metabolism.
And the health medicine preparation method is simple, production cost is low.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of meals health-care drug and its preparation sides
Method, to solve caused by existing health medicine eutrophication, a series of illnesss and health-care effect are poor, are not easy to absorb and make
The technical issues of Preparation Method is complicated, production cost is high；
The present invention is achieved by the following technical solutions：The invention discloses a kind of meals health-care drug, including following
Raw material：Tea oil, polysorbate -80, maltodextrin, magnesium stearate, Chinese medical extract, rice flour, vitamin D, lucidum spore powder,
Starch and calcium carbonate, wherein the components by weight percent of each raw material is：
Wherein, tea oil also known as camellia oil, camellia seed oil are the C. olelfera mature seeds from Theaceae Camellia Plants
The hatvral food plants oil of middle extraction.Tea oil is similar to the ingredient of olive oil, and olive oil reaches 75%- containing unrighted acid
90%, the unrighted acid in tea oil is then up to 85%-97%, is the hat of various edible oils.Contain olive oil institute in tea oil
No specific physiological activator tea polyphenols and camellianin can effectively improve cardiovascular and cerebrovascular disease, reduce cholesterol and empty stomach
Blood glucose, the raising for restraining triglyceride, to cancer cell is inhibited also to have the effect of apparent.Meanwhile the molecular structure of tea oil compares olive
Oil is also thin, so not having to worry side effect, greasy when edible；
Polysorbate -80 has the double effects of emulsification and grease hydrotropy, is greatly improved human body to meals health-care drug
Digestion and absorption；
Magnesium stearate, vitamin D and calcium carbonate are the common health food of human body；It can be provided for human body required
Calcium, magnesium, iron plasma and required vitamin improve cell activity；
Maltodextrin can provide polysaccharide for human body and improve the mouthfeel of diet drug；
It is that drug plays vigor and promotes new containing abundant high nutrition element in Chinese medical extract, lucidum spore powder
The strong impetus of old metabolism；
Rice flour can provide needed by human body dietary fiber, promote to digest and assimilate.
Further, drug effect in order to better improve, Chinese medical extract for matrimony vine, Radix Astragali, celery and ginseng in mass ratio
1：3：4：It extracts to obtain with anhydrous ethanol solvent after 1.5~2 mixing.
Further, the medical value of meals health-care drug in order to better improve, plays its health-care effect, each raw material
Weight
Component is：
The invention also discloses the preparation method of the meals health-care drug, including following preparation process：
Step 1: the extraction of Chinese medicine
First by the matrimony vine after drying, Radix Astragali, celery and ginseng in mass ratio 1：3：4：1.5~2 are weighed, then by Chinese holly
Qi, Radix Astragali and ginseng crush, and the crushed material of three is added in the three-necked flask for being contained with absolute ethyl alcohol, heating
It is refluxed, after flowing back 3~4 hours, mixed liquor is filtered while hot, retain filtrate, ethanol extract I is made；Collect filter cake simultaneously
It is put into three-necked flask again, the filter cake is heated at reflux again with absolute ethyl alcohol, after filtering, retains filtrate,
Obtain ethanol extract II；Ethanol extract I and ethanol extract II are merged, after being spin-dried for vacuum rotary evaporator, obtained
Concentrate feed A, it is spare；It is abundant dissolving in order to improve nutrient inside Chinese medicine that mixed liquor is filtered while hot, prevents extraction not
Fully；Filter cake is flowed back also for better extraction organic nutrient substance again；
Step 2: the extraction of adjuvant
It pours into and is contained in the three-necked flask of absolute ethyl alcohol after celery load weighted in step 1 is crushed, be heated to reflux stirring
It mixes, after flowing back 30 minutes, filters while hot, collect filtrate, obtain adjuvant extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；Celery
Juice helps to treat the diseases such as high blood pressure, hypertensive arteriosclerosis, can prevent body eutrophication, improves meals health-care
The safety of drug；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, Chinese medical extract is obtained, and places it in the irradiation that sterilizes under ultraviolet lamp, it is standby
With；
Step 4: batch mixing
Weigh maltodextrin, magnesium stearate, rice flour, vitamin D, lucidum spore powder and calcium carbonate, and by above-mentioned raw materials
It is crushed with pulverizer, places into material screening machine after being sieved, obtain batch mixing object；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and tea oil, polysorbate -80 and starch are sequentially added into the wet mixing pelletizer, it is bonded with absolute ethyl alcohol
Agent, granulation；It is dried, cured with baking oven；Then whole grain is carried out again；
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Further, in order to prevent temperature it is too low can not be flowed back, extract and temperature is excessively high can be by matrimony vine, Radix Astragali
With the nutrition oxidation operation in ginseng, the temperature being heated to reflux in step 1 and step 2 is controlled at 80~85 DEG C.
Further, in order to preferably promote absorption of the human body to diet drug, the sieve used that is sieved in step 4 is
200 mesh screens.
Further, in order to bulk pharmaceutical chemicals is allowed to be easier to cure, body is promoted to absorb, in step 5 starch for cornstarch or
Potato starch；At 70~80 DEG C, baking time is 30~45 minutes for oven temperature control in step 5.
Further, in order to preferably be eaten convenient for human body and reasonable supplement nutrient, whole grain is passed through in step 5
Meals health-care drug weight afterwards is controlled at 0.35 ± 0.01g/, is eaten convenient for eater.
The invention discloses a kind of meals health-care drugs and preparation method thereof, this meals health-care drug can not only provide people
Various nutrients needed for body, but also rich in enough unrighted acids, dosage used is suitable for vast Chinese population
Dietary.Body aging symptom can effectively be alleviated, cell viability is improved, boost metabolism.And the health care medicinal
Product also have the characteristics that preparation method is simple, production cost is low.
Specific embodiment
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, give detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Embodiment 1 discloses a kind of meals health-care drug, including following raw material：Tea oil, polysorbate -80, malt magma
Essence, magnesium stearate, Chinese medical extract, rice flour, vitamin D, lucidum spore powder, starch and calcium carbonate, wherein the weight of each raw material
Component is：50 parts of tea oil, 80 parts of polysorbates -80,50 parts of maltodextrins, 35 parts of magnesium stearates, 25 parts of Chinese medical extracts, 20
Part rice flour, 5 parts of vitamin Ds, 20 parts of lucidum spore powders, 53 parts of cornstarch and 10 parts of calcium carbonate.
The preparation method of the meals health-care drug includes following preparation process：
Step 1: the extraction of Chinese medicine
The 10g matrimony vines after drying, 30g Radix Astragalis, 40g celeries and 15g ginsengs are first weighed, then by matrimony vine, Radix Astragali and ginseng
It crushes, and the crushed material of three is added in the three-necked flask for being contained with 150ml absolute ethyl alcohols, be heated to reflux stirring
It mixes, the temperature being heated to reflux is controlled at 80 DEG C, and after flowing back 3 hours, mixed liquor is filtered while hot, retains filtrate, and ethyl alcohol is made
Extracting solution I；It collects filter cake and puts into it in three-necked flask again, carry out reflux again to filter cake with 100ml absolute ethyl alcohols and add
Heat, the temperature being heated to reflux is controlled at 85 DEG C, after filtering, is retained filtrate, is obtained ethanol extract II；By ethanol extract I
Merge with ethanol extract II, after being spin-dried for vacuum rotary evaporator, obtain concentrate feed A, it is spare；
Step 2: the extraction of adjuvant
It pours into the three-necked flask for being contained with 150ml absolute ethyl alcohols, adds after 40g celeries load weighted in step 1 are crushed
Heat is refluxed, and the temperature being heated to reflux is controlled at 85 DEG C, after flowing back 30 minutes, is filtered while hot, is collected filtrate, is obtained adjuvant
Extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, 25 parts of Chinese medical extract is obtained, and place it under ultraviolet lamp and sterilize
Irradiation, it is spare；
Step 4: batch mixing
Weigh 50g maltodextrins, 35g magnesium stearates, 20g rice flour, 5g vitamin Ds, 20g lucidum spore powders and 10g carbon
Sour calcium crushes above-mentioned raw materials with pulverizer, places into material screening machine after being sieved with 200 mesh screens, obtains batch mixing object；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and 50g tea oil, 80g polysorbates -80 and 53g cornstarch or potato are sequentially added into wet mixing pelletizer
Starch makees adhesive with 30ml absolute ethyl alcohols, granulation；It is dried, cured with baking oven, oven temperature is controlled at 80 DEG C, is baked
Time is 30 minutes；Then whole grain is carried out again；Meals health-care drug weight after whole grain is controlled at 0.35 ± 0.01g/.
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Embodiment 2
Embodiment 2 discloses a kind of meals health-care drug, including following raw material：40 parts of tea oil, 75 parts of polysorbates -80,
45 parts of maltodextrins, 35 parts of magnesium stearates, 25 parts of Chinese medical extracts, 20 parts of rice flour, 5 parts of vitamin Ds, 15 parts of Reishi sporules
Powder, 50 parts of starch and 10 parts of calcium carbonate, wherein, Chinese medical extract is matrimony vine, Radix Astragali, celery and ginseng in mass ratio 1：3：4：
1.5 mixing extractions obtain
The preparation method of the meals health-care drug includes following preparation process：
Step 1: the extraction of Chinese medicine
The 10g matrimony vines after drying, 30g Radix Astragalis, 40g celeries and 15g ginsengs are first weighed, then by matrimony vine, Radix Astragali and ginseng
It crushes, and the crushed material of three is added in the three-necked flask for being contained with 150ml absolute ethyl alcohols, be heated to reflux stirring
It mixes, the temperature being heated to reflux is controlled at 80 DEG C, and after flowing back 4 hours, mixed liquor is filtered while hot, retains filtrate, and ethyl alcohol is made
Extracting solution I；It collects filter cake and puts into it in three-necked flask again, carry out reflux again to filter cake with 100ml absolute ethyl alcohols and add
Heat, the temperature being heated to reflux is controlled at 80 DEG C, after filtering, is retained filtrate, is obtained ethanol extract II；By ethanol extract I
Merge with ethanol extract II, after being spin-dried for vacuum rotary evaporator, obtain concentrate feed A, it is spare；
Step 2: the extraction of adjuvant
It pours into the three-necked flask for being contained with 150ml absolute ethyl alcohols, adds after 40g celeries load weighted in step 1 are crushed
Heat is refluxed, and the temperature being heated to reflux is controlled at 80 DEG C, after flowing back 30 minutes, is filtered while hot, is collected filtrate, is obtained adjuvant
Extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, the Chinese medical extract of 25 parts by weight is obtained, and place it under ultraviolet lamp
Sterilizing irradiation, it is spare；
Step 4: batch mixing
Weigh 45 parts of maltodextrins, 35 parts of magnesium stearates, 20 parts of rice flour, 5 parts of vitamin Ds, 15 parts of lucidum spore powders and
10 parts of calcium carbonate crush above-mentioned raw materials with pulverizer, place into material screening machine after being sieved with 200 mesh screens, are mixed
Material；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and 40 parts of tea oil, 75 parts of polysorbates -80 and 50 parts of potato starch are sequentially added into wet mixing pelletizer, it uses
40ml absolute ethyl alcohols make adhesive, granulation；It is dried, cured with baking oven, oven temperature control is at 70 DEG C, baking time 30
Minute；Then whole grain is carried out again；Meals health-care drug weight after whole grain is controlled at 0.35 ± 0.01g/.
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Embodiment 3
Embodiment 3 discloses a kind of meals health-care drug, including following raw material：50 parts of tea oil, 95 parts of polysorbates -80,
60 parts of maltodextrins, 50 parts of magnesium stearates, 30 parts of Chinese medical extracts, 30 parts of rice flour, 8 parts of vitamin Ds, 20 parts of Reishi sporules
Powder, 55 parts of starch and 20 parts of calcium carbonate, wherein, Chinese medical extract is matrimony vine, Radix Astragali, celery and ginseng in mass ratio 1：3：4：2
Mixing extraction obtains
The preparation method of the meals health-care drug includes following preparation process：
Step 1: the extraction of Chinese medicine
First by the matrimony vine after drying, Radix Astragali, celery and ginseng in mass ratio 1：3：4：2 are weighed, then by matrimony vine, Huang
Stilbene and ginseng crush, and the crushed material of three is added in the three-necked flask for being contained with 150ml absolute ethyl alcohols, heating
It is refluxed, the temperature being heated to reflux is controlled at 85 DEG C, and after flowing back 4 hours, mixed liquor is filtered while hot, retains filtrate, system
Obtain ethanol extract I；It collects filter cake and puts into it in three-necked flask again, filter cake is carried out again with 100ml absolute ethyl alcohols
It is heated at reflux, the temperature being heated to reflux is controlled at 85 DEG C, after filtering, is retained filtrate, is obtained ethanol extract II；Ethyl alcohol is carried
Liquid I and ethanol extract II is taken to merge, after being spin-dried for vacuum rotary evaporator, obtains concentrate feed A, it is spare；
Step 2: the extraction of adjuvant
It pours into the three-necked flask for being contained with 150ml absolute ethyl alcohols, heats after celery load weighted in step 1 is crushed
It is refluxed, the temperature being heated to reflux is controlled at 85 DEG C, after flowing back 30 minutes, is filtered while hot, is collected filtrate, is obtained adjuvant and carry
Take liquid；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, the Chinese medical extract of 30 parts by weight is obtained, and place it under ultraviolet lamp
Sterilizing irradiation, it is spare；
Step 4: batch mixing
Weigh 60 parts of maltodextrins, 50 parts of magnesium stearates, 30 parts of rice flour, 8 parts of vitamin Ds, 20 parts of lucidum spore powders and
20 parts of calcium carbonate crush above-mentioned raw materials with pulverizer, place into material screening machine after being sieved with 200 mesh screens, are mixed
Material；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and 50 parts of tea oil, 95 parts of polysorbates -80 and 55 parts of cornstarch are sequentially added into wet mixing pelletizer, it uses
40ml absolute ethyl alcohols make adhesive, granulation；It is dried, cured with baking oven, oven temperature control is at 80 DEG C, baking time 45
Minute；Then whole grain is carried out again；Meals health-care drug weight after whole grain is controlled at 0.35 ± 0.01g/.
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Embodiment 4
Embodiment 4 discloses a kind of meals health-care drug, including following raw material：45 parts of tea oil, 80 parts of polysorbates -80,
50 parts of maltodextrins, 44 parts of magnesium stearates, 28 parts of Chinese medical extracts, 25 parts of rice flour, 6 parts of vitamin Ds, 18 parts of Reishi sporules
Powder, 52 parts of starch and 15 parts of calcium carbonate, wherein, Chinese medical extract is matrimony vine, Radix Astragali, celery and ginseng in mass ratio 1：3：4：2
Mixing extraction obtains
The preparation method of the meals health-care drug includes following preparation process：
Step 1: the extraction of Chinese medicine
The 10g matrimony vines after drying, 30g Radix Astragalis, 40g celeries and 15g ginsengs are first weighed, then by matrimony vine, Radix Astragali and ginseng
It crushes, and the crushed material of three is added in the three-necked flask for being contained with 150ml absolute ethyl alcohols, be heated to reflux stirring
It mixes, the temperature being heated to reflux is controlled at 82 DEG C, and after flowing back 4 hours, mixed liquor is filtered while hot, retains filtrate, and ethyl alcohol is made
Extracting solution I；It collects filter cake and puts into it in three-necked flask again, carry out reflux again to filter cake with 100ml absolute ethyl alcohols and add
Heat, the temperature being heated to reflux is controlled at 85 DEG C, after filtering, is retained filtrate, is obtained ethanol extract II；By ethanol extract I
Merge with ethanol extract II, after being spin-dried for vacuum rotary evaporator, obtain concentrate feed A, it is spare；
Step 2: the extraction of adjuvant
It pours into the three-necked flask for being contained with 150ml absolute ethyl alcohols, adds after 40g celeries load weighted in step 1 are crushed
Heat is refluxed, and the temperature being heated to reflux is controlled at 85 DEG C, after flowing back 30 minutes, is filtered while hot, is collected filtrate, is obtained adjuvant
Extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, the Chinese medical extract of 28 parts by weight is obtained, and place it under ultraviolet lamp
Sterilizing irradiation, it is spare；
Step 4: batch mixing
Weigh 50 parts of maltodextrins, 44 parts of magnesium stearates, 25 parts of rice flour, 6 parts of vitamin Ds, 18 parts of lucidum spore powders and
15 parts of calcium carbonate crush above-mentioned raw materials with pulverizer, place into material screening machine after being sieved with 200 mesh screens, are mixed
Material；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and 45 parts of tea oil, 80 parts of polysorbates -80 and 52 parts of cornstarch are sequentially added into wet mixing pelletizer, it uses
40ml absolute ethyl alcohols make adhesive, granulation；It is dried, cured with baking oven, oven temperature control is at 75 DEG C, baking time 45
Minute；Then whole grain is carried out again；Meals health-care drug weight after whole grain is controlled at 0.35 ± 0.01g/.
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Embodiment 5
Embodiment 5 discloses a kind of meals health-care drug, including following raw material：47 parts of tea oil, 83 parts of polysorbates -80,
52 parts of maltodextrins, 40 parts of magnesium stearates, 28 parts of Chinese medical extracts, 24 parts of rice flour, 7 parts of vitamin Ds, 15 parts of Reishi sporules
Powder, 53 parts of starch and 16 parts of calcium carbonate, wherein, Chinese medical extract is matrimony vine, Radix Astragali, celery and ginseng in mass ratio 1：3：4：2
Mixing extraction obtains
The preparation method of the meals health-care drug includes following preparation process：
Step 1: the extraction of Chinese medicine
The 10g matrimony vines after drying, 30g Radix Astragalis, 40g celeries and 15g ginsengs are first weighed, then by matrimony vine, Radix Astragali and ginseng
It crushes, and the crushed material of three is added in the three-necked flask for being contained with 150ml absolute ethyl alcohols, be heated to reflux stirring
It mixes, the temperature being heated to reflux is controlled at 82 DEG C, and after flowing back 4 hours, mixed liquor is filtered while hot, retains filtrate, and ethyl alcohol is made
Extracting solution I；It collects filter cake and puts into it in three-necked flask again, carry out reflux again to filter cake with 100ml absolute ethyl alcohols and add
Heat, the temperature being heated to reflux is controlled at 85 DEG C, after filtering, is retained filtrate, is obtained ethanol extract II；By ethanol extract I
Merge with ethanol extract II, after being spin-dried for vacuum rotary evaporator, obtain concentrate feed A, it is spare；
Step 2: the extraction of adjuvant
It pours into the three-necked flask for being contained with 150ml absolute ethyl alcohols, adds after 40g celeries load weighted in step 1 are crushed
Heat is refluxed, and the temperature being heated to reflux is controlled at 85 DEG C, after flowing back 30 minutes, is filtered while hot, is collected filtrate, is obtained adjuvant
Extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After concentrate feed A and concentrate feed B is mixed, 28 parts of Chinese medical extract is obtained, and place it under ultraviolet lamp and sterilize
Irradiation, it is spare；
Step 4: batch mixing
Weigh 50 parts of maltodextrins, 44 parts of magnesium stearates, 25 parts of rice flour, 6 parts of vitamin Ds, 18 parts of lucidum spore powders and
15 parts of calcium carbonate crush above-mentioned raw materials with pulverizer, place into material screening machine after being sieved with 200 mesh screens, are mixed
Material；
Step 5: granulation, curing, whole grain
Batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and 45 parts of tea oil, 80 parts of polysorbates -80 and 52 parts of cornstarch are sequentially added into wet mixing pelletizer, it uses
40ml absolute ethyl alcohols make adhesive, granulation；It is dried, cured with baking oven, oven temperature control is at 75 DEG C, baking time 45
Minute；Then whole grain is carried out again；Meals health-care drug weight after whole grain is controlled at 0.35 ± 0.01g/.
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
Drug effect statistical data：
| Trace Elements in Blood | Medication first trimester (ug/g) | Three months after medication (ug/g) |
| Calcium | 905.8 | 1120.1 |
| Magnesium | 83.6 | 96.3 |
| Zinc | 125.5 | 206.6 |
| Iron | 83.1 | 92.5 |
By carrying out drug effect statistics to ten adult males and ten women in this area.Medication first trimester, every
Blood testing was carried out to Adult Groups in five days, count the blood content of the trace element such as calcium, magnesium, zinc and iron in blood examination；Then again
To these Demographics take medicine after in three months Trace Elements in Blood blood content；Then it is averaged and is compared.Into
Year crowd custom to be kept relative stability in terms of diet in three months after medication first trimester and medication, avoids empty stomach labor
The improper phenomenons such as work, unhealthy diet.The diet calcium tablet that medication first trimester is also sold according to market is taken, one day two
It is secondary, each two panels；It takes tablet of the present invention and mode is taken using identical.
It can be seen that by the data comparison of six months after taking pill of the present invention, calcium, magnesium, iron, zinc in human body etc. are micro-
Secondary element all has increased significantly.
Professional production is won by hundred Aurion of Beijing and supplies cell ageing detection kit to each crowd progress cell detection.
Operating procedure is as follows：
1. prepare cell or tissue sample strip softly to be washed with PBS three times.
2. fixer is added dropwise in every 100ul, room temperature fixes 10min.
3. sucking fixer, PBS is softly washed three times.
4. prepare dyeing working solution (before use, is completely dissolved the X-gal of 10mg, then by itself and dye with 250 μ l dyeing liquors B
The abundant mixings of color liquid A, 2-8 DEG C is protected from light, matching while using), every is added dropwise 100ul or so dyeing liquor working solution, 37 degree of nothings by dosage
It is protected from light in CO2 incubators 10 hours.
5. being observed under ordinary optical microscope, three different visuals field are counted respectively, calculate the positive cell number of blue dye.
Experiment show to take mitochondria quantity after this pill in human body cell significantly before taking this pill than
More, fission process is more active.Illustrate this pill while needed by human body trace element is increased, to the break-up energy of cell
Power also increases, and can effectively alleviate the aging of cell.
1. XX, man, 43 years old, no other illnesss was done manual work in one's early years in other places over a long time, and life is irregular.Now have returned to
Native place carries out simple crops cultivation.Calcium, magnesium, zinc, iron content average value are respectively in medication first trimester blood
903.2ug/g, 86.1ug/g, 120.3ug/g and 80.9ug/g, wrinkle are more serious；After taking this pill three months, in blood
Calcium, magnesium, zinc, iron content average value have respectively reached 1026.2ug/g, 98.1ug/g, 220.3ug/g and 95.9ug/g, and wrinkle is bright
Aobvious to mitigate, appetite significantly increases.
2. Lee X, female 35 years old, have given birth to, real estate project manager needs to investigate building site for a long time, measure；Diet
Aspect is relatively simple.Calcium in medication first trimester blood, magnesium, zinc, iron content average value be respectively 880.2ug/g, 83.5ug/g,
144.3ug/g and 75.8ug/g, skin fluid loss are more serious；After taking this pill three months, calcium, magnesium, zinc, iron contain in blood
Amount average value has respectively reached 1006.2ug/g, 85.1ug/g, 170.3ug/g and 85.9ug/g, has rosy cheeks, canthus line is gradual
Desalination.
3. Lee XX, man, 47 years old, no other illnesss, civil servant, rule of life.Take medicine first trimester blood in calcium, magnesium, zinc,
Iron content average value is respectively 1110.2ug/g, 92.1ug/g, 135.3ug/g and 86.1ug/g, and wrinkle is more serious；Take this
After pill three months, in blood calcium, magnesium, zinc, iron content average value respectively reached 1250.2ug/g, 97.1ug/g,
215.3ug/g and 97ug/g, wrinkle is substantially reduced, and appetite increased.
4. woods XX, female, 47 years old, peasant woman followed husband to be in and manages aquaculture；It is relatively simple in terms of diet.Before medication
Calcium, magnesium, zinc, iron content average value are respectively 980.2ug/g, 88.5ug/g, 157.3ug/g and 90.8ug/ in three months blood
G, wrinkle are deeper；After taking this pill three months, calcium, magnesium, zinc, iron content average value have respectively reached 1112.2ug/ in blood
G, 88.1ug/g, 192.3ug/g and 94ug/g have rosy cheeks, and wrinkle is gradually desalinated.
Claims (9)
1. a kind of meals health-care drug, which is characterized in that the meals health-care drug includes following raw material：Tea oil, polysorbate-
80th, maltodextrin, magnesium stearate, Chinese medical extract, rice flour, vitamin D, lucidum spore powder, starch and calcium carbonate, wherein institute
The components by weight percent for stating each raw material is：
2. meals health-care drug as described in claim 1, which is characterized in that the Chinese medical extract is matrimony vine, Radix Astragali, celery
With ginseng in mass ratio 1：3：4：It extracts to obtain with anhydrous ethanol solvent after 1.5~2 mixing.
3. meals health-care drug as described in claim 1, which is characterized in that the components by weight percent of each raw material is：
4. a kind of preparation method of meals health-care drug as described in any one of claims 1-3, which is characterized in that
Including following preparation process：
Step 1: the extraction of Chinese medicine
First by the matrimony vine after drying, Radix Astragali, celery and ginseng in mass ratio 1：3：4：1.5~2 are weighed, then by matrimony vine,
Radix Astragali and ginseng crush, and the crushed material of three is added in the three-necked flask for being contained with absolute ethyl alcohol, heat back
Stream stirring, after flowing back 3~4 hours, mixed liquor is filtered while hot, retains filtrate, and ethanol extract I is made；Collection filter cake simultaneously will
It is put into three-necked flask again, and the filter cake is heated at reflux again with absolute ethyl alcohol, after filtering, is retained filtrate, is obtained
To ethanol extract II；The ethanol extract I and ethanol extract II are merged, after being spin-dried for vacuum rotary evaporator, obtained
It is spare to concentrate feed A；
Step 2: the extraction of adjuvant
It pours into and is contained in the three-necked flask of absolute ethyl alcohol after celery load weighted in step 1 is crushed, be heated to reflux stirring,
It after reflux 30 minutes, filters while hot, collects filtrate, obtain adjuvant extracting solution；After vacuum is spin-dried for, concentrate feed B is obtained；
Step 3: the preparation of Chinese medical extract
After the concentrate feed A and concentrate feed B is mixed, Chinese medical extract is obtained, and places it in the irradiation that sterilizes under ultraviolet lamp, it is standby
With；
Step 4: batch mixing
Weigh maltodextrin, magnesium stearate, rice flour, vitamin D, lucidum spore powder and calcium carbonate, and by above-mentioned raw materials powder
Broken machine crushes, and places into material screening machine after being sieved, obtains batch mixing object；
Step 5: granulation, curing, whole grain
The batch mixing object is poured into step 3 and is stirred in Chinese medical extract obtained, is together poured into wet mixing pelletizer
Mixing, and tea oil, polysorbate -80 and starch are sequentially added into the wet mixing pelletizer, it is bonded with absolute ethyl alcohol
Agent, granulation；It is dried, cured with baking oven；Then whole grain is carried out again；
Step 6: packaging
Meals health-care drug is obtained after whole grain, then dress, outer packing is wrapped inside in granular meals health-care drug.
5. the preparation method of meals health-care drug as claimed in claim 4, which is characterized in that described in step 1 and step 2
The temperature being heated to reflux is controlled at 80~85 DEG C.
6. the preparation method of meals health-care drug as claimed in claim 4, which is characterized in that be sieved sieve used in step 4
Net is 200 mesh screens.
7. the preparation method of meals health-care drug as claimed in claim 4, which is characterized in that starch described in step 5 is jade
Rice starch or potato starch.
8. the preparation method of meals health-care drug as claimed in claim 4, which is characterized in that oven temperature controls in step 5
At 70~80 DEG C, baking time is 30~45 minutes.
9. the preparation method of meals health-care drug as claimed in claim 4, which is characterized in that in step 5 after whole grain
Meals health-care drug weight is controlled at 0.35 ± 0.01g/.
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Application publication date: 20180626 |