CN1081915C - Method for preparation of cream of chinese medicines - Google Patents
Method for preparation of cream of chinese medicines Download PDFInfo
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- CN1081915C CN1081915C CN98113604A CN98113604A CN1081915C CN 1081915 C CN1081915 C CN 1081915C CN 98113604 A CN98113604 A CN 98113604A CN 98113604 A CN98113604 A CN 98113604A CN 1081915 C CN1081915 C CN 1081915C
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- oil
- cream
- chinese medicine
- raw material
- oil phase
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Abstract
The present invention relates to a method for the preparation of Chinese medicine cream. Adopted Chinese herbal medicine or natural raw material is respectively decocted and extracted; oil is extracted for correspondingly obtaining a water phase and an oil phase; then, the water phase and the oil phase are mixed and emulsified for obtaining Chinese medicine cream. The present invention can be used for reforming Chinese medicine external preparations. The Chinese medicine cream prepared by the present invention integrally comprises effective components of the adopted raw material and has the advantages of high crude medicine concentration, easy percutaneous absorption, high biologic utilization degree, fine and lustrous external appearance, good use effect and easy carrying, use and washing. The present invention can use the existing Chinese medicine production apparatus. The used raw material has the advantage of low cost and is suitable for large-scale production and small-scale production.
Description
The present invention relates to a kind of method of producing the Chinese medicine cream.
In the prior art, Chinese medicine tradition ointment method for making generally has: mix with vaseline substrate with oily hot dipping leaching oil immersion liquid; Or be concentrated into extractum with decocting decoct medicinal herbs material and mix with substrate such as vaseline.Because medicinal herb components is complicated, existing water-soluble composition such as alkaloid salt, tannin, aminoacid and water-soluble organic acid etc. have oil-soluble composition such as multiple glycoside unit, alkaloid, coumarin, lactone, flavone, anthraquinone, aromatic acid etc. again; And often water-soluble material oil-soluble is poor, is dissolved in the material poorly water-soluble of oil, and therefore all there is the shortcoming that the part effective ingredient is difficult to extract in above-mentioned two kinds of method for makings.
Purpose of the present invention is exactly to provide a kind of method of producing the Chinese medicine cream at the problems referred to above, and this method can overcome above-mentioned shortcoming the effective ingredient in Chinese herbal medicine or other natural material is had extraction effect preferably.
Technical scheme provided by the invention is, a kind of method of producing the Chinese medicine cream, selected Chinese herbal medicine or natural material are decocted extraction and deserved water of oily extract phase and oil phase respectively, oil extracts and adopts Chinese herbal medicine or the leaching of natural material oiling lipid raw material that will select for use, then water and oil phase are heated to 65-80 ℃ respectively, and mix to stir carry out emulsifying to coagulate the Chinese medicine cream.
The oil phase that above-mentioned mixing stirring and emulsifying mode can adopt the water after will heating slowly to pour into after the heating carries out emulsifying (also oil phase can be poured into water emulsifying), and aqueous phase can add polyhydric alcohol such as glycerols material.
Described aqueous phase also can include as three ethanol of emulsifying agent and/or potassium hydroxide and/or sodium lauryl sulphate.
And the cream that makes with this law contains (percetage by weight): polyhydric alcohol 5～20%, triethanolamine 0～2%, potassium hydroxide 0～0.4%, sodium lauryl sulphate 0～1%, Chinese herbal medicine decocting and concentrating liquid 45～65%, Chinese herbal medicine oil strain 15～40%.
Also can add stearic acid and/or glyceryl monostearate and/or white beeswax (or paraffin) and/or fatty acids such as vaseline and/or liquid paraffin, oils raw material in the above-mentioned oil phase.
And the addition of above-mentioned fatty acid, oils raw material is (accounting for the percentage by weight of Chinese medicine cream): stearic acid 10～15%, glyceryl monostearate 0～5%, white beeswax (paraffin) 0～5%, vaseline 0～15%, liquid paraffin 0～10%.
The present invention since will selected Chinese herbal medicine or natural material decoct respectively extract and oil extract make the water-soluble effective ingredient that is insoluble in oil in the above-mentioned raw materials be dissolved in the effective ingredient that oil is insoluble in water and all can effectively extract, and the mixed Chinese medicine cream that gets, make the Chinese medicine cream that makes with the present invention more intactly comprise the effective ingredient of selected raw material and have result of use preferably.
In addition the Chinese medicine cream that makes of the present invention also has the following advantages: 1. contain crude drug concentration and be higher than conventional dosage forms; 2. be easy to Transdermal absorption, bioavailability height; 3. the outward appearance exquisiteness is glossy; 4. be easy to carry about with one and use and clean.
The present invention can utilize existing Chinese medicine production equipment, is suitable for the production of large and small scale.The used cost of raw material of the present invention is low, can optionally design in the product and add other animals and plants extraction composition or specific western medicine composition.
Below in conjunction with embodiment the present invention is further described.
Water extraction of the present invention (decoct and extract) can adopt traditional decocting method.As selected Chinese herbal medicine or natural material are decocted with water three times, the merging decoction liquor is concentrated into quantitative filtration and promptly gets decocting and concentrating liquid or water.
Moisture retention, aqueous phase can add polyhydric alcohol such as glycerol in order to make prepared cream have preferably.
The oil that the present invention relates to extract Chinese herbal medicine that the oily hot dipping that can adopt tradition system Chinese medicine oil preparation or unguentum is about to select for use or natural material refuel the lipid raw material as; Vegetable oil, white beeswax, vaseline, liquid paraffin, glyceryl monostearate, stearic acid etc. leach to medical material withered and yellow filter Chinese herbal medicine oil strain or oil phase.Also can add the performance that fatty acid, oils raw material such as stearic acid and/or glyceryl monostearate and/or white beeswax (or paraffin) and/or vaseline and/or liquid paraffin (its addition sees the following form) are beneficial to emulsifying better and improve cream in the oil phase.
The emulsifying agent that the present invention relates to can be selected for use as required, as selects triethanolamine and/or potassium hydroxide and/or sodium lauryl sulphate, Borax etc. for use.
When Chinese herbal medicine or natural material are extracted, can be with they separated into two parts, a part is carried out water extraction, and a part is carried out oil and is extracted; Also oil extracts earlier, again excess is carried out water extraction.
Above-mentioned water and oil phase are heated to 65～80 ℃ (the best equalities of temperature of water and oil phase) respectively, with water slowly pour into oil phase (or pour oil phase into water) stirring and emulsifying to coagulate the Chinese medicine cream, in the packing materials such as flexible pipe or box of packing into then.
Rotten when preventing that the Chinese medicine cream from storing, can in the Chinese medicine cream, add antiseptic.Following table be above-mentioned produce that the selected raw material of cream accounts for cream percentage ratio respectively organize embodiment:
| Embodiment percentage ratio % component | One | Two | Three | Four | Five | Six |
| The Chinese herbal medicine concentrated solution | 45 | 52 | 48 | 55 | 58 | 65 |
| Polyhydric alcohol or glycerol | 5 | - | 12 | 15 | 20 | 10 |
| Triethylamine | - | 0.5 | 0.9 | 0.5 | 2 | - |
| Potassium hydroxide | - | - | 0.1 | 0.4 | - | 0.2 |
| Sodium lauryl sulphate | 1.0 | 0.5 | - | 0.1 | - | 0.8 |
| The Chinese herbal medicine oil strain | 40 | 30 | 22 | 12 | 15 | 10 |
| Stearic acid | - | - | 15 | - | - | 10 |
| Glyceryl monostearate | - | - | - | 5 | - | 2 |
| White beeswax or paraffin | 5 | 2 | - | 2 | - | - |
| Vaseline | - | 15 | - | - | 5 | 2 |
| Liquid paraffin | 4 | - | 2 | 10 | - | - |
Claims (7)
1. method of producing the Chinese medicine cream, it is characterized in that comprising following process, selected Chinese herbal medicine or natural material are decocted extraction and deserved water of oily extract phase and oil phase respectively, oil extracts and adopts Chinese herbal medicine or the leaching of natural material oiling lipid raw material that will select for use, then water and oil phase are heated to 65-80 ℃ respectively, and mix to stir carry out emulsifying to coagulate the Chinese medicine cream.
2. method according to claim 1 is characterized in that mixing the oil phase that the stirring and emulsifying mode slowly pours into after the heating for the water after will heating and carries out emulsifying, and aqueous phase is added with polyhydric alcohol.
3. method according to claim 2 is characterized in that aqueous phase is added with triethanolamine and/or potassium hydroxide and/or the sodium lauryl sulphate as emulsifying agent.
4. method according to claim 3, it is characterized in that containing (percetage by weight) with the cream that this law makes, polyhydric alcohol 5～20%, triethanolamine 0～2%, potassium hydroxide 0～0.4%, sodium lauryl sulphate 0～1%, Chinese herbal medicine decocting and concentrating liquid 45～65%, Chinese herbal medicine oil strain 15～40%.
5. according to the described arbitrary method of claim 1～4, it is characterized in that being added with in the oil phase fatty acid and/or oil raw material.
6. method according to claim 5 is characterized in that fatty acid and/or oil raw material are stearic acid and/or glyceryl monostearate and/or white beeswax (or paraffin) and/or vaseline and/or liquid paraffin.
7. method according to claim 6, it is characterized in that the addition that above-mentioned fat spins acid, oils raw material is (accounting for the percentage by weight of Chinese medicine cream), stearic acid 10～15%, glyceryl monostearate 0～5%, white beeswax (paraffin) 0～5%, vaseline 0～15%, liquid paraffin 0～10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113604A CN1081915C (en) | 1998-06-22 | 1998-06-22 | Method for preparation of cream of chinese medicines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113604A CN1081915C (en) | 1998-06-22 | 1998-06-22 | Method for preparation of cream of chinese medicines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1201662A CN1201662A (en) | 1998-12-16 |
| CN1081915C true CN1081915C (en) | 2002-04-03 |
Family
ID=5223315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98113604A Expired - Fee Related CN1081915C (en) | 1998-06-22 | 1998-06-22 | Method for preparation of cream of chinese medicines |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1081915C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718290A (en) * | 2019-03-20 | 2019-05-07 | 龚小妹 | It dispels miliaria compound pomelo peel frost and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064212A (en) * | 1991-02-11 | 1992-09-09 | 宋明春 | Skin ﹠ complexion improving cream and preparation method thereof |
| CN1110132A (en) * | 1994-04-08 | 1995-10-18 | 拜忠信 | Wrinkles-resisting spot-removing cosmetic cream and its preparing method |
| CN1110582A (en) * | 1994-04-26 | 1995-10-25 | 胡耀祖 | "Shangtongling" emulsion and its preparation method |
-
1998
- 1998-06-22 CN CN98113604A patent/CN1081915C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064212A (en) * | 1991-02-11 | 1992-09-09 | 宋明春 | Skin ﹠ complexion improving cream and preparation method thereof |
| CN1110132A (en) * | 1994-04-08 | 1995-10-18 | 拜忠信 | Wrinkles-resisting spot-removing cosmetic cream and its preparing method |
| CN1110582A (en) * | 1994-04-26 | 1995-10-25 | 胡耀祖 | "Shangtongling" emulsion and its preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718290A (en) * | 2019-03-20 | 2019-05-07 | 龚小妹 | It dispels miliaria compound pomelo peel frost and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1201662A (en) | 1998-12-16 |
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