CN1110582A

CN1110582A - "Shangtongling" emulsion and its preparation method

Info

Publication number: CN1110582A
Application number: CN 94112136
Authority: CN
Inventors: 胡大佑; 李伟元; 胡耀祖
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-04-26
Filing date: 1994-04-26
Publication date: 1995-10-25

Abstract

The O/W-type massage cream for curing acute and chronic soft tissue injury and joint adhesion after bone fracture with obvious curative effect is prepared through such steps as extracting active components from 15 Chinmese-medicinal materials, stirring with volatile plant oil, Tween-80, nitrone and distilled water, and emulsifying, and features high penetration power, no irritation to skin and not dirting clothes.

Description

"Shangtongling" emulsion and its preparation method

" Shangtongling " emulsion is a kind of massage Emulsion of the pain that specially cures the wound.

Treat acute or chronic soft tissue injury at present both at home and abroad, diseases such as fracture posterior joint adhesion, the Chinese medicine of restore funcitons generally adopts extremity side of washing or plaster or varnish.Medicines such as grieved cream, spasmolysis and analgesia tincture, fracture are peaceful have stimulation to skin, easily take place skin allergy, also can the greasy dirt medicated clothing and the penetration that has not strong.If adopt black plaster also often need add a little Chinese medicines, as Cinnabaris, Borneolum Syntheticum or Moschus.Moschus moschiferous is the state guarantee animal, and Moschus is expensive rare, generally must not adopt.Black plaster is strong to the zest of skin, and near the hairpencil position, the plaster of tearing causes local inflammation often, is difficult to cleaning skin again as if the affected part.Bubble is fried in shallow oil with Chinese crude drug by the extremity side of washing, the grieved place of thermal washing, scalded skin, particularly child patient easily.Also having a major defect is that the Chinese crude drug external preparation is that the Chinese crude drug water boiling concentration forms, and easily goes mouldy to hide for a long time, and this is the insurmountable problem of traditional preparation process method for thousands of years.

The object of the present invention is to provide a kind of is that base stock is made with the Chinese crude drug, and penetration is strong, and the curative effect height is non-stimulated to skin, and pollution clothes does not go mouldy, the Emulsion of the pain that specially cures the wound easy to use.

The present invention realizes by following technology.

Adopt the external washout with traditional Chinese herbs side of the late expert's long-term clinical application that cures the wound of China, it is made up of ten Chinese medicine of the five flavours materials, has Radix Aconiti, Radix Aconiti Kusnezoffii, horse to give a farewell dinner son, Radix Aconiti Lateralis Preparata, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Ramulus Mori, river CAOXIE, Fructus Chaenomelis, Herba sambuci chinensis, Olibanum, Myrrha, Herba Epimedii, river Niu Xi.Use the chemical method of modern science and technology and extract its active ingredient, main effective pharmacology composition of these Chinese crude drugs is as follows: the river, the biological alkali of Radix Aconiti Kusnezoffii, horse is given a farewell dinner son: kind wooden alkali, horse is given a farewell dinner biological alkali such as sub-alkali, Radix Aconiti Lateralis Preparata: biological alkali, Radix Angelicae Pubescentis: volatile oil, Coumarins, the Fructus Citri Sarcodactylis lactone, Rhizoma Et Radix Notopterygii: the volatilization wet goods, Ramulus Cinnamomi: volatile oil, composition is a cinnamic aldehyde in the oil, Ramulus Mori: Chuan CAOXIE such as succinic acid: multiple steroid saponin such as dioscin, Fructus Chaenomelis: Saponin, flavonoid etc., Herba sambuci chinensis: triterpenes, flavonoid glycoside such as Asiaticoside, Herba Epimedii: icariine etc., river Niu Xi: triterpenoid saponin oleanolic acid etc., Olibanum, Myrrha: resin, natural gum and volatile oil.Extract and add vegetalitas volatile oil, tween 80 (polyethenoxy sorbitan list olein), azone, ethanol, distilled water again after the active ingredient, make a kind of O/W(oil/water through stirring and emulsifying) type Emulsion.

Here recommend the prescription of a ten Chinese medicine of the five flavours materials, percentage meter by weight, ratio is as follows: Radix Aconiti, Radix Aconiti Kusnezoffii, horse are given a farewell dinner son, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Ramulus Mori, Sichuan Cordyceps

, Fructus Chaenomelis, Herba sambuci chinensis, Olibanum, Myrrha are 6～6.75%, Radix Aconiti Lateralis Preparata, Herba Epimedii, river Niu Xiwei 6.3～9.3%.

The preparation method of " Shangtongling " emulsion:

(1) pulverizing above-mentioned ten Chinese medicine of the five flavours materials, to become fineness be 2mm, can be by the medicated powder that sieves for No. 1.

(2) Radix Aconiti Kusnezoffii, horse are given a farewell dinner son, Radix Aconiti Lateralis Preparata medicated powder and put into container in ratio separately, flood at normal temperatures with 75% ethanol (ETOH) and to carry out diafiltration after 24 hours, collect filtrate, filtrate with the potassium iodide titration till the precipitation, after reclaiming ethanol, dry that powder (I) is standby with dry nebulization;

Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi medicated powder are put into container in ratio separately add water retting and distill after 4 hours, collect distillate, redistillation is also collected distillate, use the petroleum ether extraction distillate, and the reclaim under reduced pressure petroleum ether is must extract (II) standby;

The medicated powder of other medical material is put into container by usage ratio (can add Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi residue for making full use of medical material) separately, decoct with water secondary, each 1 hour, concentrate after collecting secondary filtrate, cold preservation concentrated solution 24 hours filters, and adds 60% ethanol and must mix filtrate, decompression recycling ethanol then, it is standby filtrate to be spray dried to powdery thing (III) again;

(3) powder I 15.5%-23.5%

Extract II 10%-16%

Powder III 35.5%-45.5%

Wintergreen oil 25%-30%

More than be weight percentage.

Tween 80 6ml

Azone 6ml

Ethanol an amount of (2-3ml)

Add distilled water and make Emulsion 250ml

Get wintergreen oil and the extract II is mixed into (A), I, III are added an amount of dissolve with ethanol become (B), tween 80 added in the distilled water becomes (C), (A), (B) are gone into respectively to stir vibration in (C), add azone, adding distil water stirs evenly emulsifying and gets O/W type " Shangtongling " emulsion 250ml to capacity again.

Above-mentioned preparation method is represented with a process chart, sees accompanying drawing (1).

Embodiment:

(1) ten Chinese medicine of the five flavours materials is pulverized, sieved with No. 1 sieve.

In (2) ten five tastes medicated powder, Radix Aconiti Lateralis Preparata, Herba Epimedii, living cattle sunset respectively account for 9.3% of gross weight, are every flavor 93 grams, and 12 flavors respectively account for 6% of gross weight in addition, for every flavor 60 grams, amount to 999 grams.

(3) Radix Aconiti Kusnezoffii, horse are given a farewell dinner each 60 gram of son, Radix Aconiti Lateralis Preparata 93 restrains, and medicated powder is gone into container, with the dipping diafiltration in 24 hours down of 75%ETOH room temperature, collect filtrate, and the potassium iodide titration is precipitation extremely, reclaims ETOH, and dry spraying gets powder (I);

Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, each 60 gram of Ramulus Cinnamomi, medicated powder is gone into container, adds water retting 4 hours, through second distillation.Receive the distillate petroleum ether extraction, reclaim petroleum ether, extract (volatile oil) II;

Each 60 gram of Radix Aconiti, Ramulus Mori, Chuan CAOXIE, Fructus Chaenomelis, Herba sambuci chinensis, Olibanum, Myrrha, Herba Epimedii, river cattle sunset each 93 gram and the residue of Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi go into container, decoct secondary, each 1 hour.Collection secondary filtrate concentrates cold preservation 24 hours, filters with the buchner funnel nutsch filter, adds 60%ETOH, must mix filtrate, reclaims ETOH again, with the filtrate spray drying, gets powder (III).Can prepare (I), (II), (III), with standby more.

(4) get powder (I) 165 grams, extract (II) 150 grams, powder (III) 385 grams, wintergreen oil 300 grams.Wintergreen oil 300 grams and extract (volatile oil) II 150 gram mixings are become (A), powder (I) and (III) adding 20-30mlETOH dissolving are become (B).Get tween 80 60ml, adding in the distilled water becomes (C), and (A), (B) are gone into respectively to stir vibration in (C), adds azone, adds distilled water again to capacity, stirs evenly emulsifying and gets O/W type " Shangtongling " emulsion 2500ml.

This Emulsion can add spice, makes to have the different cream of odor type.

Exemplify four parts of clinical observation tables, the three all pain of four patients after using " Shangtongling " emulsion obviously alleviates, and activity freely.See accompanying drawing (2), (3), (4), (5).

The " Shangtongling " emulsion tool is to the effect that heat-clearing and toxic substances removing, anti-inflammatory analgesic, inducing diuresis to remove edema, relaxing muscles and tendons to promote blood circulation, easing joint movement are arranged, and it is unfavorable to cure mainly traumatic injury, soreness of waist and knee joint, rheumatism paralysis, limb edema pain, joint action.Treat various acute or chronic soft tissue injuries, fracture posterior joint adhesion etc. take effect rapidly, and curative effect is lasting, efficacy stability.Only needing during use that Emulsion is applied in the affected part massage gets final product.It has intensive penetration to epiderm skin, can the differentially expanding blood vessel, accelerate blood circulation, and impel drug absorption.Non-stimulated to skin, can pollution clothes yet.It can not hidden for a long time and can go mouldy, and portably uses all very conveniently, is a kind of new-type traditional Chinese preparation.

The pain intensity classification: 1. not pain or once in a while pain be;

2. when static when movable bitterly pain be;

3. when static and when movable all be bitterly;

4. pain is difficult to stand, and influences work, life.

Mobility classification: 1. be freely;

2. be limited as slightly;

3. limited mostly being;

4. obviously be limited as.

The patient estimates: comfortable with aftersensation, pain obviously alleviates, and activity obviously increases to excellent freely;

Comfortable with aftersensation, pain relief, movable from good if any being improved as;

Comfortable with aftersensation, pain degree alleviates not obvious, and mobility does not have to increase to and still can;

Uncomfortable with aftersensation, pain degree, mobility no change, side effect is arranged is poor.

Claims

1, " Shangtongling " emulsion, with Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni, Radix Aconiti Lateralis Preparata, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Ramulus Mori, river CAOXIE, Fructus Chaenomelis, Herba sambuci chinensis, Olibanum, Myrrha, Herba Epimedii, river Niu Xishi Chinese medicine of the five flavours material is base stock, it is characterized in that extracting effective pharmacology composition that above-mentioned medical material includes a kind of O/W (oil/water) type Emulsion that add vegetalitas volatile oil, tween 80 (polyethenoxy sorbitan list olein), azone, ethanol, distilled water, makes through stirring and emulsifying with chemical method.

2, " Shangtongling " emulsion according to claim 1 is characterized in that ten Chinese medicine of the five flavours material compatibilities by weight percentage, and ratio is as follows:

Radix Aconiti, Radix Aconiti Kusnezoffii, horse candied fruit, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Ramulus Mori, river CAOXIE, Fructus Chaenomelis, Herba sambuci chinensis, Olibanum, Myrrha are 6～6.75%, Radix Aconiti Lateralis Preparata, Herba Epimedii, river Niu Xiwei 6.3～9.3%.

3, the preparation method of " Shangtongling " emulsion is characterized in that:

(1) pulverizing ten Chinese medicine of the five flavours materials becomes the about 2mm of fineness, can be by the medicated powder of No. 1 sieve;

(2) Radix Aconiti Kusnezoffii, horse are given a farewell dinner son, Radix Aconiti Lateralis Preparata medicated powder and put into container by usage ratio separately and flood diafiltration in 24 hours at normal temperatures, collect filtrate (potassium iodide, titration is till the precipitation) with 75% ethanol, recovery ethanol, drying is sprayed to such an extent that powder (I) is standby;

With Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi medicated powder (in ratio separately) dipping after 4 hours, through second distillation and collect distillate, use the petroleum ether extraction distillate, the reclaim under reduced pressure petroleum ether, must extract (II) standby;

The medicated powder of other medical material decocts secondary, each 1 hour by the residue of usage ratio separately and Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi.Concentrate after collecting secondary filtrate, 24 hours after-filtration of cold preservation concentrated solution add 60% ethanol and must mix filtrate, and it is standby that decompression recycling ethanol is spray dried to filtrate powdery thing (III) again;