CN101401800A - Gamma-ethyl linolenate soft capsule and preparation thereof - Google Patents
Gamma-ethyl linolenate soft capsule and preparation thereof Download PDFInfo
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- CN101401800A CN101401800A CNA200710180680XA CN200710180680A CN101401800A CN 101401800 A CN101401800 A CN 101401800A CN A200710180680X A CNA200710180680X A CN A200710180680XA CN 200710180680 A CN200710180680 A CN 200710180680A CN 101401800 A CN101401800 A CN 101401800A
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- oil
- soft capsule
- vitamin
- oenotherae erythrosepalae
- radix oenotherae
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Abstract
The invention discloses a gama-linolenic acid ethyl soft capsule and a process for preparing the same. The components in the soft capsule comprise evening primrose oil, vitamin E oil, and glycerin with the proportion being 392 to 2 to 57. The process for preparing the soft capsule comprises the following: step one, preparing the evening primrose oil through a supercritical extraction method; step two, uniformly mixing the evening primrose oil, the vitamin E oil, and the glycerin according to the proportion of 392 to 2 to 57; and step three, filling the mixture into capsule shells according to the standard that each capsule contains 400 milligrams of content. The stability of gama-linolenic acid can be improved through esterification treatment; the vitamin E is added into the soft capsule to improve the product stability and prevent the soft capsule from being oxidized; the form of soft capsule can separate the content from the external aerobic environment and is convenient to take and carry around. The process adopts the supercritical extraction method to extract the evening primrose oil, thus the preparation process has the advantages of short extraction time, high separation efficiency, low operation temperature, and no solvent pollution.
Description
Technical field
The present invention relates to a kind of gamma-ethyl linolenate soft capsule and preparation technology thereof.
Background technology
Radix Oenotherae erythrosepalae, another name Radix Oenotherae erythrosepalae, Radix Helicteris belong to 2 years these plants of SHENGCAO of Oenotheraceae.Its North America, original producton location, the introducing and planting success of back China.Sophisticated evening primrose seed is very little, is pitchy, out-of-shape, and there is wedge angle on the surface, its crude fiber content 40%, fat content 22-30%, wherein fatty acid consists of, gamma-linolenic acid content 7%, linoleic acid content 80%, oleic acid content 8%, Palmic acid and stearic acid content 5%.Radix Oenotherae erythrosepalae is a kind of new oil that is rich in multiple unsaturated fatty acid, and its gamma-linolenic acid content is higher.Gamma-Linolenic acid is the highly unsaturated fatty acid that a kind of human body self can not synthesize and have important physiologically active, it with keep the human body cell normal function, transform and utilize cholesterol, to form prostaglandin etc. closely related.In recent years, because the continuous discovery and the application of the unique medicines and health protection effect of gamma-Linolenic acid, Radix Oenotherae erythrosepalae oil has caused the great attention of biochemistry, botany, medical and health circle in the world.At present, Radix Oenotherae erythrosepalae oil is used widely as the additive of medicine, the raw material of cosmetics and nutraceutical, and realizes commercialization in the whole world rapidly.
Linoleic acid is to be prevalent in the intravital nutrient substance of humans and animals.A large amount of studies have shown that linoleic acid and linoleic acid second fat are one of essential fatty acids, in animal body, linoleic acid is synthetic arachidonic precursor, and the latter is the raw material of synthesis of prostaglandins, and therefore, it directly affects growth and the fertility of animal.Linoleic acid and Ethyl linoleate have the effect that reduces serum cholesterol and low-density lipoprotein cholesterol.Aspect medical, linoleic acid and derivant thereof are mainly as the medicine that prevents and treat diseases such as arteriosclerosis, as beniol, linoleic acid, linoleic acid capsule etc.
Present existing gamma-Linolenic acid Related product, how unreasonable because of Radix Oenotherae erythrosepalae oil and other proportioning components, do not have good medical care effect.
At present, the technical matters of month grass oil of preparation both at home and abroad mainly is that machine presses method and solvent extraction method.The oil yield that machine presses method technology is low, cake Residual oil height.The equipment complexity of leaching method, investment is big, and the operating maintenance difficulty is big.Crude oil acid number height, color and luster are dark, and be refining loss big.Need the deodorize of high temperature precipitation, valuable components is easily lost, and therefore influences the product oil quality.
Summary of the invention
The object of the present invention is to provide a kind of gamma-ethyl linolenate soft capsule and preparation technology thereof.
The technical solution used in the present invention is: this gamma-ethyl linolenate soft capsule, the shell of soft capsule is made with gelatin, composition in the soft capsule is Radix Oenotherae erythrosepalae oil, vitamin E oil, glycerol, and its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E oil: glycerol=398: 2: 57.
Above-mentioned gamma-Linolenic acid ester preparation of soft capsule technology, the first step, seed of Radix Oenotherae erythrosepalae with 50kg drops in the extraction kettle of two 100L through pulverizing respectively, extraction temperature is controlled at 45 ℃, flow-control is at 200L/H, and the single still 3 hours time of extraction, pressure is controlled at 20Mpa, two extraction kettles switched once in three hours, obtained Radix Oenotherae erythrosepalae oil in separating still; Second step is with Radix Oenotherae erythrosepalae oil, vitamin E oil, the glycerol ratio uniform mixing in 398: 2: 57; In the 3rd step,, the mixture of Radix Oenotherae erythrosepalae oil, vitamin E oil and glycerol is incapsulated in the shell by every standard that contains 400 milligrams of contents.
Owing to taked technique scheme, the present invention through esterification treatment, can improve the stability of gamma-Linolenic acid; Add vitamin E, improve product stability, prevent oxidized; Be processed into soft capsule and extraneous aerobic environment separates, and conveniently take and carry.The present invention takes supercritical extraction extracting oenothera oil, compares with solvent extraction method with the machine method of pressing, and demonstrates short, technical advantages such as separation efficiency is high, operative temperature is low, solvent-free pollution of extraction time.
The specific embodiment
This gamma-ethyl linolenate soft capsule, the shell of soft capsule is made with gelatin, and the composition in the soft capsule is Radix Oenotherae erythrosepalae oil, vitamin E oil, glycerol, and its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E oil: glycerol=398: 2: 57.
Above-mentioned gamma-Linolenic acid ester preparation of soft capsule technology, the first step, seed of Radix Oenotherae erythrosepalae with 50kg drops in the extraction kettle of two 100L through pulverizing respectively, extraction temperature is controlled at 45 ℃, flow-control is at 200L/H, and the single still 3 hours time of extraction, pressure is controlled at 20Mpa, two extraction kettles switched once in three hours, obtained Radix Oenotherae erythrosepalae oil in separating still; Second step is with Radix Oenotherae erythrosepalae oil, vitamin E oil, the glycerol ratio uniform mixing in 398: 2: 57; In the 3rd step,, the mixture of Radix Oenotherae erythrosepalae oil, vitamin E oil and glycerol is incapsulated in the shell by every standard that contains 400 milligrams of contents.
Claims (2)
1, a kind of gamma-ethyl linolenate soft capsule is characterized in that: the shell of soft capsule is made with gelatin, and the composition in the soft capsule is Radix Oenotherae erythrosepalae oil, vitamin E oil, glycerol, and its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E oil: glycerol=398: 2: 57.
2, a kind of gamma-Linolenic acid ester preparation of soft capsule technology as claimed in claim 1, it is characterized in that: the first step, seed of Radix Oenotherae erythrosepalae with 50kg drops in the extraction kettle of two 100L through pulverizing respectively, extraction temperature is controlled at 45 ℃, flow-control is at 200L/H, and the single still 3 hours time of extraction, pressure is controlled at 20Mpa, two extraction kettles switched once in three hours, obtained Radix Oenotherae erythrosepalae oil in separating still; Second step is with Radix Oenotherae erythrosepalae oil, vitamin E oil, the glycerol ratio uniform mixing in 398: 2: 57; In the 3rd step,, the mixture of Radix Oenotherae erythrosepalae oil, vitamin E oil and glycerol is incapsulated in the shell by every standard that contains 400 milligrams of contents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710180680XA CN101401800A (en) | 2007-10-03 | 2007-10-03 | Gamma-ethyl linolenate soft capsule and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710180680XA CN101401800A (en) | 2007-10-03 | 2007-10-03 | Gamma-ethyl linolenate soft capsule and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101401800A true CN101401800A (en) | 2009-04-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200710180680XA Pending CN101401800A (en) | 2007-10-03 | 2007-10-03 | Gamma-ethyl linolenate soft capsule and preparation thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103596453A (en) * | 2011-05-30 | 2014-02-19 | 林来福医药公司 | Health-giving foodstuff containing ethyl esters of fatty acids, namely of linen oil, and method for obtaining the same |
| CN104068402A (en) * | 2014-06-29 | 2014-10-01 | 宁波市成大机械研究所 | Soft seal oil capsule containing gamma-linolenic acid |
| CN115969037A (en) * | 2023-03-02 | 2023-04-18 | 贵州恒生源农业开发有限公司 | Production process of oil tea soft capsules |
-
2007
- 2007-10-03 CN CNA200710180680XA patent/CN101401800A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103596453A (en) * | 2011-05-30 | 2014-02-19 | 林来福医药公司 | Health-giving foodstuff containing ethyl esters of fatty acids, namely of linen oil, and method for obtaining the same |
| CN104068402A (en) * | 2014-06-29 | 2014-10-01 | 宁波市成大机械研究所 | Soft seal oil capsule containing gamma-linolenic acid |
| CN115969037A (en) * | 2023-03-02 | 2023-04-18 | 贵州恒生源农业开发有限公司 | Production process of oil tea soft capsules |
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Open date: 20090408 |