CN108186701A - A kind of chitosan oligosaccharide capsule and preparation method thereof - Google Patents
A kind of chitosan oligosaccharide capsule and preparation method thereof Download PDFInfo
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- CN108186701A CN108186701A CN201810130905.9A CN201810130905A CN108186701A CN 108186701 A CN108186701 A CN 108186701A CN 201810130905 A CN201810130905 A CN 201810130905A CN 108186701 A CN108186701 A CN 108186701A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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Abstract
The invention discloses a kind of chitosan oligosaccharide capsules and preparation method thereof, and including content and softgel shell, the content includes chitosan, chitosan oligosaccharide, taurine and ginsenoside, and the softgel shell includes cornstarch, algin, lauryl sodium sulfate and water.The chitosan oligosaccharide capsule of the present invention, which has, preferably to be improved the immunity of the human body, and alleviates the effect of physical fatigue；The free from extraneous odour of capsule prepared by the preparation method of capsule using the present invention, smooth in appearance, dissolution rate is high, is conducive to absorption of human body, and capsule caking good fluidity not easy to moisture absorption prepared by the present invention.
Description
Technical field
The invention belongs to pharmaceutical technology field, specifically, being related to a kind of chitosan oligosaccharide capsule and preparation method thereof.
Background technology
Chitosan oligosaccharide (chtiosnaoligosaccharide, COS) be Glucosamine and N-acetylglucosamine with β-
The homopolymer or heteropolymer that 1,4 glucosides key connections form.COS is unique a large amount of existing alkaline polysaccharides in natural sugar, in addition to tool
Outside the property for having similar chitosan, also have that viscosity is low, and good water solubility, molecular weight is small, be easily absorbed and utilized and degradable etc.
Advantage, bioactivity and functional character are all more superior than chitosan.It is good water-soluble that numerous studies show that chitosan oligosaccharide has
Property and be easy to be absorbed by organism, different physiological roles are revealed to organism surface, according to it is related research chitosan oligosaccharide have lower hyperlipidemia, hypertension, hyperglycemia, protect
Liver shield kidney, anti-oxidant, raising is immune, enhancing bone density, improves enteron aisle, inhibits tumour and other effects.
With the development of world economy and science and technology, the whole world progresses into aging society, and the increase of elderly population makes
Various infirmitiess of age it is increased, for example, hypoimmunity, human body is easily tired, researches and develops novel health food for carrying
High immunity of organisms excludes the toxin of body accumulation, has great importance to prevent and reduce various diseases.
For these reasons, it is special to propose the present invention.
Invention content
In order to solve problem above of the existing technology, the present invention provides a kind of chitosan oligosaccharide capsule and its preparation sides
Method.The chitosan oligosaccharide of the invention has good strengthen immunity, alleviates the effect of organism fatigue, long-term use can improve body
Immunity excludes toxin, enhances the ability resisted the disease, while the raw material of the preparation method is cheap and easy to get, preparation method is simple.
The first object of the present invention, provides a kind of chitosan oligosaccharide capsule, the content include chitosan, chitosan oligosaccharide,
Taurine and ginsenoside, the softgel shell include cornstarch, algin, lauryl sodium sulfate and water.
Chitosan has higher protein adsorption ability；In the work of degrading enzyme (lysozyme lysozyme, kitinase)
Under, chitosan tool degradability；Chitosan is easy to be processed into line, is suitble to make linear or sheet medical material；Chitosan
With affinity and dissolubility, suitable for producing each analog derivative；Chitosan has higher chemism；The water holding of chitosan
Property it is high；In serum, the degradable absorption of chitosan；Chitosan has higher biological degradability；Chitosan has shown selection
Property height inhibit the effect of Streptococcus oralis growth, while have no effect on the growth of other beneficial bacterias, human body can be improved
Immunity.
Chitosan oligosaccharide (chtiosnaoligosaccharide, COS) be Glucosamine and N-acetylglucosamine with β-
The homopolymer or heteropolymer that 1,4 glucosides key connections form.COS is unique a large amount of existing alkaline polysaccharides in natural sugar, in addition to tool
Outside the property for having similar chitosan, also have that viscosity is low, and good water solubility, molecular weight is small, be easily absorbed and utilized and degradable etc.
Advantage, bioactivity and functional character are all more superior than chitosan.It is good water-soluble that numerous studies show that chitosan oligosaccharide has
Property and be easy to be absorbed by organism, different physiological roles are revealed to organism surface, according to it is related research chitosan oligosaccharide have lower hyperlipidemia, hypertension, hyperglycemia, protect
Liver shield kidney, anti-oxidant, raising is immune, enhancing bone density, improves enteron aisle, inhibits tumour and other effects.
Taurine in cow-bezoar initially by separating, therefore taurine of gaining the name, and taurine maintains brain normal function, changes
Kind memory, promotes infant's intellectual development, is conducive to the normal maintenance of visual performance, protects eyesight, improves vision, is conducive to
Human eye cell membrane maintains normal function, and human nerve is conducted and is adjusted, and promotes cranial nerve development, lipoid material is promoted to absorb,
And inhibit the generation of cholelith, enhance myocardial contractive power, reduce blood pressure, reduce blood glucose, cardioprotection and detoxication, promote growth
Development, promotes the secretion of human growth hormone, can build up health to human body, dispelling fatigue, improves routine work efficiency, prevention
Disease etc..
Ginsenoside is a kind of steroid compound, is primarily present in Panax medicinal material, being the active constituent in ginseng,
Immune function of human body can be increased, improve immunity, antifatigue effect.
The chitosan oligosaccharide capsule of the present invention has preferable strengthen immunity, delays by the synergistic effect of above-mentioned several substances
Solve the effect of limbs fatigue.
Further, according to parts by weight, the content includes chitosan 40-50 parts by weight, chitosan oligosaccharide 50-60 weight
Part, taurine 20-30 parts by weight and ginsenoside 3-8 parts by weight, the softgel shell include cornstarch 5-10 parts by weight, seaweed
Glue 2-5 parts by weight, lauryl sodium sulfate 3-6 parts by weight and water 15-20 parts by weight.
Further, according to parts by weight, the content includes 45 parts by weight of chitosan, 55 parts by weight of chitosan oligosaccharide, ox
5 parts by weight of 27.6 parts by weight of sulfonic acid and ginsenoside, the softgel shell include 7 parts by weight of cornstarch, 3.5 weight of algin
Part, 17 parts by weight of 4.5 parts by weight of lauryl sodium sulfate and water.
The second object of the present invention provides a kind of preparation method of the chitosan oligosaccharide capsule, the preparation method packet
Include following steps：
(1) the above object is weighed respectively and softgel shell is spare；
(2) raw material of component content object is dried, grinds, be stirred, obtain fine powder；
(3) obtained fine powder is subjected to wet granulation, obtains content；
(4) corn starch ground is crushed, adds in algin, lauryl sodium sulfate and water and be uniformly mixed, it is dry,
Glue is dipped in, is dried, is demoulded, cutting, fitting obtains softgel shell；
(5) content that step (3) obtains is filled in the softgel shell in step (4), obtains the chitosan oligosaccharide capsule.
Further, the drying temperature in step (2) is 60-70 DEG C, and drying time is 12-15 hours.
Further, it is ground to 120-140 mesh in step (2).
Present disclosure object is ground to 120-140 mesh, by largely testing discovery, the dissolution rate of the capsule of preparation compared with
Height, stability is preferable, is conducive to the safe handling of clinical medicine and long-term storage.
Further, the temperature of wet granulation is 30-35 DEG C in step (3), humidity 28-32%.
Using above-mentioned pelleting temperature and humidity, the capsule caking not easy to moisture absorption and good fluidity of preparation.
Further, dry moisture is less than 8% after granulation in step (3).
Further, temperature dry in step (4) is 65-70 DEG C, drying time 2.5-3.5h.
Further, the temperature that glue is dipped in step (4) is 55-60 DEG C.
Compared with prior art, beneficial effects of the present invention are as follows：
(1) chitosan oligosaccharide capsule of the invention has and preferably improves the immunity of the human body, and alleviates the effect of physical fatigue；
(2) free from extraneous odour of capsule prepared by the preparation method of capsule using the present invention, smooth in appearance, dissolution rate is high, has
Conducive to absorption of human body, and capsule caking good fluidity not easy to moisture absorption prepared by the present invention.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical scheme of the present invention will be carried out below
Detailed description.Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all under the premise of creative work is not made
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The chitosan oligosaccharide capsule of the present embodiment, including content and softgel shell, according to parts by weight, the content gathers including shell
Sugared 40 parts by weight, 3 parts by weight of 50 parts by weight of chitosan oligosaccharide, 20 parts by weight of taurine and ginsenoside, the softgel shell include corn
5 parts by weight of starch, 15 parts by weight of 2 parts by weight of algin, 3 parts by weight of lauryl sodium sulfate and water.
The preparation method of the chitosan oligosaccharide capsule of this hair embodiment includes the following steps：
(1) the above object is weighed respectively and softgel shell is spare；
(2) raw material of component content object is dried, drying temperature is 60 DEG C, and drying time is 12 hours, and grinding is ground
120 mesh are milled to, are stirred, obtain fine powder；
(3) obtained fine powder is subjected to wet granulation, the temperature of wet granulation is 30 DEG C, and humidity 28% is done after granulation
Dry moisture is less than 8%, obtains content；
(4) corn starch ground is crushed, adds in algin, lauryl sodium sulfate and water and be uniformly mixed, it is dry,
Dry temperature is 65 DEG C, and drying time 2.5h dips in glue, and the temperature for dipping in glue is 55 DEG C, is dried, and is demoulded, and cutting, fitting obtains
Softgel shell；
(5) content that step (3) obtains is filled in the softgel shell in step (4), obtains the chitosan oligosaccharide capsule.
Embodiment 2
The chitosan oligosaccharide capsule of the present embodiment, including content and softgel shell, according to parts by weight, the content gathers including shell
Sugared 45 parts by weight, 5 parts by weight of 5 parts by weight of chitosan oligosaccharide, 27.6 parts by weight of taurine and ginsenoside, the softgel shell include corn
7 parts by weight of starch, 17 parts by weight of 3.5 parts by weight of algin, 4.5 parts by weight of lauryl sodium sulfate and water.
The preparation method of the chitosan oligosaccharide capsule of this hair embodiment includes the following steps：
(1) the above object is weighed respectively and softgel shell is spare；
(2) raw material of component content object to be dried, drying temperature is 65 DEG C, and drying time is 13.5 hours, grinding,
130 mesh are ground to, are stirred, obtain fine powder；
(3) obtained fine powder is subjected to wet granulation, the temperature of wet granulation is 32 DEG C, and humidity 30% is done after granulation
Dry moisture is less than 8%, obtains content；
(4) corn starch ground is crushed, adds in algin, lauryl sodium sulfate and water and be uniformly mixed, it is dry,
Dry temperature is 67 DEG C, and drying time 3h dips in glue, and the temperature for dipping in glue is 57 DEG C, is dried, and is demoulded, and cutting, fitting obtains capsule
Shell；
(5) content that step (3) obtains is filled in the softgel shell in step (4), obtains the chitosan oligosaccharide capsule.
Embodiment 3
The chitosan oligosaccharide capsule of the present embodiment, including content and softgel shell, according to parts by weight, the content gathers including shell
Sugared 50 parts by weight, 8 parts by weight of 60 parts by weight of chitosan oligosaccharide, 30 parts by weight of taurine and ginsenoside, the softgel shell include corn
10 parts by weight of starch, 20 parts by weight of 5 parts by weight of algin, 6 parts by weight of lauryl sodium sulfate and water.
The preparation method of the chitosan oligosaccharide capsule of this hair embodiment includes the following steps：
(1) the above object is weighed respectively and softgel shell is spare；
(2) raw material of component content object is dried, drying temperature is 70 DEG C, and drying time is 15 hours, and grinding is ground
140 mesh are milled to, are stirred, obtain fine powder；
(3) obtained fine powder is subjected to wet granulation, the temperature of wet granulation is 35 DEG C, and humidity 32% is done after granulation
Dry moisture is less than 8%, obtains content；
(4) corn starch ground is crushed, adds in algin, lauryl sodium sulfate and water and be uniformly mixed, it is dry,
Dry temperature is 70 DEG C, and drying time 3h dips in glue, and the temperature for dipping in glue is 60 DEG C, is dried, and is demoulded, and cutting, fitting obtains capsule
Shell；
(5) content that step (3) obtains is filled in the softgel shell in step (4), obtains the chitosan oligosaccharide capsule.
Test example 1
Laboratory sample 1-3 is chitosan oligosaccharide capsule prepared by embodiment 1-3；
Control sample 1：The chitosan oligosaccharide capsule prepared according to CN105380924A embodiments 1.
Experimental method：Take experimental rat 80, half male and half female, 6-8 week old, 250 ± 50g of weight is divided into four groups, every group 20
Only, difference feeding trial sample 1-3 and control sample 1, dosage all same, daily noon timing gavage is primary, continuously feeds 30
After it, rat items immune indexes are detected.
Antibody-producting cell measures (Jerne improves slide methods) rat carbon particle clearance test, and experimental result is shown in Table 1.
Table 1
| Group | Hemolysis plaque number (× 103/ full spleen) |
| Laboratory sample 1 | 134.51 |
| Laboratory sample 2 | 135.69 |
| Laboratory sample 3 | 132.59 |
| Control sample 1 | 101.25 |
The chitosan oligosaccharide capsule prepared as can be seen from the above table using the present invention can effectively improve rat Ab than control sample
Cellulation number, that is, have the function of strengthen immunity.
2 dissolution determination of test example
Laboratory sample 1-3 is chitosan oligosaccharide capsule prepared by embodiment 1-3；
Control sample 1：The chitosan oligosaccharide capsule prepared according to CN105380924A embodiments 1.
Dissolution detection method：According to《2010 editions second annex XC dissolution determination methods of Chinese Pharmacopoeia》Determination experiment
The dissolution rate of sample and control sample, the results are shown in Table 2.
Table 2
As can be seen from the above table, the dissolution rate of chitosan oligosaccharide capsule of the invention is higher than control sample, illustrates the present invention's
Chitosan oligosaccharide capsule has preferable dissolution rate.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can readily occur in change or replacement, should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of chitosan oligosaccharide capsule, including content and softgel shell, which is characterized in that it is few that the content includes chitosan, shell
Sugar, taurine and ginsenoside, the softgel shell include cornstarch, algin, lauryl sodium sulfate and water.
2. a kind of chitosan oligosaccharide capsule according to claim 1, which is characterized in that according to parts by weight, the content packet
Include chitosan 40-50 parts by weight, chitosan oligosaccharide 50-60 parts by weight, taurine 20-30 parts by weight and ginsenoside 3-8 parts by weight, institute
The softgel shell stated includes cornstarch 5-10 parts by weight, algin 2-5 parts by weight, lauryl sodium sulfate 3-6 parts by weight and water 15-
20 parts by weight.
3. a kind of chitosan oligosaccharide capsule according to claim 1, which is characterized in that according to parts by weight, the content packet
Include 45 parts by weight of chitosan, 5 parts by weight of 55 parts by weight of chitosan oligosaccharide, 27.6 parts by weight of taurine and ginsenoside, the softgel shell
Including 7 parts by weight of cornstarch, 17 parts by weight of 3.5 parts by weight of algin, 4.5 parts by weight of lauryl sodium sulfate and water.
A kind of 4. preparation method of the chitosan oligosaccharide capsule described in claim 1-3 any one, which is characterized in that the preparation
Method includes the following steps：
(1) the above object is weighed respectively and softgel shell is spare；
(2) raw material of component content object is dried, grinds, be stirred, obtain fine powder；
(3) obtained fine powder is subjected to wet granulation, obtains content；
(4) corn starch ground is crushed, adds in algin, lauryl sodium sulfate and water and be uniformly mixed, it is dry, it dips in
Glue is dried, and is demoulded, and cutting, fitting obtains softgel shell；
(5) content that step (3) obtains is filled in the softgel shell in step (4), obtains the chitosan oligosaccharide capsule.
A kind of 5. preparation method of chitosan oligosaccharide capsule according to claim 4, which is characterized in that the drying in step (2)
Temperature is 60-70 DEG C, and drying time is 12-15 hours.
6. the preparation method of a kind of chitosan oligosaccharide capsule according to claim 4 or 5, which is characterized in that ground in step (2)
To 120-140 mesh.
A kind of 7. preparation method of chitosan oligosaccharide capsule according to claim 4 or 5, which is characterized in that wet method in step (3)
The temperature of granulation is 30-35 DEG C, humidity 28-32%.
8. the preparation method of a kind of chitosan oligosaccharide capsule according to claim 4, which is characterized in that in step (3) after granulation
Dry moisture is less than 8%.
A kind of 9. preparation method of chitosan oligosaccharide capsule according to claim 4, which is characterized in that drying in step (4)
Temperature is 65-70 DEG C, drying time 2.5-3.5h.
10. the preparation method of a kind of chitosan oligosaccharide capsule according to claim 4, which is characterized in that step dips in glue in (4)
Temperature is 55-60 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810130905.9A CN108186701A (en) | 2018-02-08 | 2018-02-08 | A kind of chitosan oligosaccharide capsule and preparation method thereof |
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| CN201810130905.9A CN108186701A (en) | 2018-02-08 | 2018-02-08 | A kind of chitosan oligosaccharide capsule and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
| CN105380924A (en) * | 2015-12-24 | 2016-03-09 | 广东药学院 | Chtiosnaoligosaccharide (COS) capsule and preparation method thereof |
-
2018
- 2018-02-08 CN CN201810130905.9A patent/CN108186701A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
| CN105380924A (en) * | 2015-12-24 | 2016-03-09 | 广东药学院 | Chtiosnaoligosaccharide (COS) capsule and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李继珩等: "金多莱牌壳寡糖复合胶囊功效作用的评价", 《万方数据》 * |
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Application publication date: 20180622 |