CN105380924A - Chtiosnaoligosaccharide (COS) capsule and preparation method thereof - Google Patents
Chtiosnaoligosaccharide (COS) capsule and preparation method thereof Download PDFInfo
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- CN105380924A CN105380924A CN201510988017.7A CN201510988017A CN105380924A CN 105380924 A CN105380924 A CN 105380924A CN 201510988017 A CN201510988017 A CN 201510988017A CN 105380924 A CN105380924 A CN 105380924A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a chtiosnaoligosaccharide (COS) capsule and a preparation method thereof. The COS capsule comprises a content and a capsule shell. The content is mainly prepared from COS, microcrystalline cellulose, adhesive, calcium stearate, ethyl alcohol and superfine silica powder. The capsule shell is mainly prepared from hydroxypropyl starch, xanthan gum, a thickening agent, a plasticizer and water. The COS capsule is free from extraneous odor, and clean, tidy and smooth in appearance; both the weight deviation and the solubility of the COS capsule meet the related stipulations of Chinese pharmacopoeia. In addition, the capsule has good leakproofness and oxidation resistance, the problem that oxidation and moisture absorption can happen to COS easily is effectively solved, and long-term storage of the COS is facilitated.
Description
Technical field
The invention belongs to pharmaceutical preparations technology field, be specifically related to a kind of chitosan oligosaccharide capsule agent and preparation method thereof.
Background technology
Oligochitosan (chtiosnaoligosaccharide, the COS) homopolymer that to be glucosamine and 2-Acetamido-2-deoxy-D-glucose be formed by connecting with β-Isosorbide-5-Nitrae glycosidic bond or heteropolymer.COS is unique a large amount of alkaline polysaccharide existed in natural sugar, and except having the character of similar chitosan, it is low that it also has viscosity, good water solubility, molecular weight is little, and easily absorb and the advantage such as degradable, its biological activity and functional character are all more superior than chitosan.Large quantity research shows, COS has adjustment blood pressure and blood lipoid, antioxidation, infection, the function such as enhancing immunity and antitumor, is a kind of ideal bioactive substance, has wide medical applications prospect.
Chinese patent CN103316031B discloses the Weight-reducing and lipid-lowering application of oligochitosan, described oligochitosan controlling body weight, reduce in content that body fat when reduces T-CHOL and low-density lipoprotein cholesterol in serum there is significant effect, show that oligochitosan has significant fat-reducing, fat-reducing effect, also there is alleviation fatty liver simultaneously, reduce the function of the blood fat in serum.
Chen Jian has delivered the paper that one section of exercise question is " researchs of oligochitosan, glucosamine anti-obesity activity and year capsaicin chitosan microball enteric coatel tablets ", this paper shows that oligochitosan has good fat-reducing effect, but also there is having no side effect, absorb fast and that looks capacitive is good advantage, be a kind of desirable slimming medicine.
But, because oligochitosan has low, the easy moisture absorption of molecular weight, oxidizable, limit its application in health product or medicine field greatly.At present, the application of oligochitosan mainly concentrates on crops aspect.Chinese patent CN102613197B discloses the purposes that oligochitosan is applied to premature senescence resistance, and described oligochitosan can the senilism of effectively preventing crop, ensures that the stable yields of agricultural increases income.Chinese patent CN101818181B discloses the method for preparing agricultural chitosan oligosaccharide by enzymolysis and the crop nutrition preparation containing oligochitosan, this nutritional preparation not only can provide nutrition for crop, stimulate plant growth, but also the breeding of harmful bacteria can be suppressed, improve the resistance against diseases of crop self.
Therefore, study and output a kind of good stability, oligochitosan dosage form that non-oxidizability is high promotes that oligochitosan applies effective way in health product or medicine field.
Summary of the invention
In order to solve low, the easy moisture absorption of molecular weight, the oxidizable defect that in prior art, oligochitosan exists, the object of the present invention is to provide a kind of chitosan oligosaccharide capsule agent and preparation method thereof, to address the aforementioned drawbacks.
The invention provides a kind of chitosan oligosaccharide capsule agent, comprise content and softgel shell, described content comprises following component and percentage by weight thereof:
Oligochitosan 80-100%, microcrystalline Cellulose 0-6%, adhesive 0-5%, calcium stearate 0-3%, ethanol 0-4% and micropowder silica gel 0-2%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 4-10 part, xanthan gum 2-6 part, thickening agent 4-8 part, plasticizer 3-6 part and water 10-20 part.
Further, described content comprises following component and percentage by weight thereof:
Oligochitosan 80-92%, microcrystalline Cellulose 2-6%, adhesive 2-5%, calcium stearate 1-3%, ethanol 2-4% and micropowder silica gel 1-2%.
Further, described content comprises following component and percentage by weight thereof:
Oligochitosan 85.5%, microcrystalline Cellulose 4%, adhesive 4%, calcium stearate 2%, ethanol 3% and micropowder silica gel 1.5%.
Further, described adhesive to be concentration be 5% povidone solution, described ethanol is dehydrated alcohol.
Further, described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 8 parts, xanthan gum 4 parts, thickening agent 5 parts, plasticizer 4 parts and 16 parts, water.
Further, described thickening agent is made up of by weight 1-2:3-4 guar gum and propylene glycol alginate, and preferably, described thickening agent is made up of by weight 1.2:3.5 guar gum and propylene glycol alginate.
Further, described plasticizer is made up of by weight 2-4:1-3 glycerol and triethyl citrate, and preferably, described plasticizer is made up of by weight 3.5:2 glycerol and triethyl citrate.
Capsule content provided by the invention adopt concentration be the povidone solution of 5% as adhesive, can improve the uniformity of granule, there will not be cannot the phenomenon of the loose or caking of granulating, grain.Select dehydrated alcohol as wetting agent, the phenomenon that oligochitosan occurs pasty state or clumps together can be prevented.Each component compatibility of Capsule content provided by the invention is reasonable, and the content prepared is dry, degree of tightness is appropriate, and moisture is qualified, meets the relevant regulations of Chinese Pharmacopoeia to Capsule content.
The molecular formula of the hydroxypropyl starch in softgel shell provided by the invention is C3H8O2x, No. CAS is 9049-76-7, it is high that it has stability, dilatancy and the good advantage of film forming characteristics, xanthan gum has the advantage of high, the good heat stability of viscosity and ph stability, is a kind of ideal biogum.Hydroxypropyl starch and the composite use of xanthan gum can improve gelation and the gelling temp of hydroxypropyl starch, are conducive to the film forming of hydroxypropyl starch.
Guar gum in softgel shell provided by the invention is a kind of nonionic galactomannan, and it has good water solublity, and presents the advantage of higher viscosity under low quality mark.Propylene glycol alginate is that the alginic acid deep processing of extracting from natural seaweed is made, and it in an acidic solution can not gelation, is a kind of thickening agent of environment-friendly type.Guar gum and propylene glycol alginate conbined usage within the scope of certain proportion, can strengthen the thickening power of propylene glycol alginate greatly.Glycerol have viscosity low, easily disperse, the feature that the compatibility is good, and triethyl citrate has the advantage that dissolubility is strong and fungus resistance is good.Glycerol and triethyl citrate conbined usage within the scope of certain proportion, has significant plasticization effect.
The each component compatibility of softgel shell provided by the invention is reasonable, and the softgel shell prepared is without foreign odor, and outward appearance is clean and tidy, do not cohere, be out of shape, seepage or softgel shell fracture phenomena, and good airproof performance, non-oxidizability are high, improve the stability of capsule greatly, be conducive to the preservation of this capsule.
In addition, present invention also offers a kind of preparation method of chitosan oligosaccharide capsule agent, comprise the following steps:
Oligochitosan, microcrystalline Cellulose, calcium stearate and micropowder silica gel are ground to form fine powder by S1, add adhesive and ethanol mix homogeneously, cross 18-25 mesh sieve, obtain fine powder;
The fine powder that step S1 obtains by S2 carries out wet granulation, and the temperature of described wet granulation is 22-28 DEG C, and humidity is 35-45%, is dried to moisture and is less than 10%, obtain content after granulation;
Hydroxypropyl starch is ground to form fine powder by S3, adds xanthan gum, thickening agent, plasticizer and water mix homogeneously, is dry 4-5h under the condition of 55-60 DEG C, then carries out dipping in glue at temperature is 50 DEG C in temperature, dries, the demoulding, cutting, and fit, obtains softgel shell;
The content that step S2 obtains by S4 is filled in the softgel shell that step S3 obtains, and is sealed by capsule, to obtain final product.
Compared with prior art, chitosan oligosaccharide capsule agent provided by the invention has following advantage:
(1) chitosan oligosaccharide capsule agent free from extraneous odour provided by the invention, outward appearance is clean and tidy, smooth, and dissolubility is high, is beneficial to the performance of drug effect, is a kind of ideal chitosan oligosaccharide capsule agent;
(2) chitosan oligosaccharide capsule agent good airproof performance provided by the invention, non-oxidizability are high, effectively can solve oligochitosan and be easy to be oxidized and the problem of the moisture absorption, be conducive to the long-term preservation of oligochitosan.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
embodiment 1,a kind of chitosan oligosaccharide capsule agent
Described content is the oligochitosan of 100%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 8 parts, xanthan gum 4 parts, thickening agent 5 parts, plasticizer 4 parts and 16 parts, water; Described thickening agent is made up of by weight 1.2:3.5 guar gum and propylene glycol alginate, and described plasticizer is made up of by weight 3.5:2 glycerol and triethyl citrate.
Preparation method:
Oligochitosan is ground to form fine powder by S1, crosses 20 mesh sieves, obtains fine powder;
The fine powder that step S1 obtains by S2 carries out wet granulation, the temperature of described wet granulation 25 DEG C, and humidity is 40%, is dried to moisture and is less than 10%, obtain content after granulation;
Hydroxypropyl starch is ground to form fine powder by S3, adds xanthan gum, thickening agent, plasticizer and water mix homogeneously, is dry 4h under the condition of 60 DEG C in temperature, then temperature be 50 DEG C write into row dip in glue, dry, the demoulding, cutting, fit, obtains softgel shell;
The content that step S2 obtains by S4 is filled in the softgel shell that step S3 obtains, and is sealed by capsule, to obtain final product.
embodiment 2,a kind of chitosan oligosaccharide capsule agent
Described content comprises following component and percentage by weight thereof:
The povidone solution 2% of oligochitosan 92%, microcrystalline Cellulose 2%, 5%, calcium stearate 1%, dehydrated alcohol 2% and micropowder silica gel 1%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 4 parts, xanthan gum 2 parts, thickening agent 4 parts, plasticizer 3 parts and 10 parts, water; Described thickening agent is made up of by weight 1:4 guar gum and propylene glycol alginate, described plasticizer by glycerol and triethyl citrate by weight 2:3 form.
Preparation method:
Oligochitosan, microcrystalline Cellulose, calcium stearate and micropowder silica gel are ground to form fine powder by S1, add povidone solution and the dehydrated alcohol mix homogeneously of 5%, cross 20 mesh sieves, obtain fine powder;
The fine powder that step S1 obtains by S2 carries out wet granulation, the temperature of described wet granulation 25 DEG C, and humidity is 40%, is dried to moisture and is less than 10%, obtain content after granulation;
Hydroxypropyl starch is ground to form fine powder by S3, adds xanthan gum, thickening agent, plasticizer and water mix homogeneously, is dry 4h under the condition of 60 DEG C in temperature, then temperature be 50 DEG C write into row dip in glue, dry, the demoulding, cutting, fit, obtains softgel shell;
The content that step S2 obtains by S4 is filled in the softgel shell that step S3 obtains, and is sealed by capsule, to obtain final product.
embodiment 3,a kind of chitosan oligosaccharide capsule agent
Described content comprises following component and percentage by weight thereof:
The povidone solution 4% of oligochitosan 85.5%, microcrystalline Cellulose 4%, 5%, calcium stearate 2%, dehydrated alcohol 3% and micropowder silica gel 1.5%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 8 parts, xanthan gum 4 parts, thickening agent 5 parts, plasticizer 4 parts and 16 parts, water; Described thickening agent is made up of by weight 1.2:3.5 guar gum and propylene glycol alginate, and described plasticizer is made up of by weight 3.5:2 glycerol and triethyl citrate.
Preparation method is similar to Example 2.
embodiment 4,a kind of chitosan oligosaccharide capsule agent
Described content comprises following component and percentage by weight thereof:
The povidone solution 5% of oligochitosan 80%, microcrystalline Cellulose 6%, 5%, calcium stearate 3%, dehydrated alcohol 4% and micropowder silica gel 2%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 10 parts, xanthan gum 6 parts, thickening agent 8 parts, plasticizer 6 parts and 20 parts, water; Described thickening agent is made up of by weight 2:3 guar gum and propylene glycol alginate, and described plasticizer is made up of by weight 4:1 glycerol and triethyl citrate.
Preparation method is similar to Example 2.
comparative example 1,a kind of chitosan oligosaccharide capsule agent
The component of described content and percentage by weight thereof are as embodiment 3.
The component of described softgel shell and parts by weight thereof are: described thickening agent is made up of by weight 3:2 guar gum and propylene glycol alginate, and all the other components are as embodiment 3.
Preparation method is similar to Example 2.
comparative example 2,a kind of chitosan oligosaccharide capsule agent
The component of described content and percentage by weight thereof are as embodiment 3.
The component of described softgel shell and parts by weight thereof are: described plasticizer is made up of by weight 1:4 glycerol and triethyl citrate, and all the other components are as embodiment 3.
Preparation method is similar to Example 2.
test example one,the quality testing test of chitosan oligosaccharide capsule agent
1, test material: the chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 preparation.
2, detection method:
With reference to the detection method of " Chinese Pharmacopoeia 2010 version two ", the content material state of chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 preparation and moisture are measured, detect the outward appearance of chitosan oligosaccharide capsule agent, stink, content uniformity and dissolubility, wherein dissolubility adopts pulpboard method to measure the dissolution of chitosan oligosaccharide capsule agent when 45min simultaneously.
3, result of the test:
Result of the test is as shown in table 1.
The quality testing result of the test of table 1 chitosan oligosaccharide capsule agent
As shown in Table 1, the content material state of chitosan oligosaccharide capsule agent prepared by embodiment of the present invention 1-4 is dry, degree of tightness appropriateness, moisture is less than 9.0%, and this capsule free from extraneous odour, outward appearance is clean and tidy, without cohering, distortion, seepage or softgel shell fracture phenomena, its content uniformity and dissolubility all meet the relevant regulations of Chinese Pharmacopoeia, and the outward appearance of capsule prepared by comparative example 1 and comparative example 2 has concavo-convex, have and cohere, distortion, seepage or softgel shell fracture phenomena, dissolution is less than 90% when 45min, all do not meet the relevant regulations of Chinese Pharmacopoeia, illustrate that capsule formula provided by the invention is reasonable, can improve the quality of products greatly, promote the promotion and application of chitosan oligosaccharide capsule agent.
test example two,the accelerated test of chitosan oligosaccharide capsule agent
1, test material: the chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 preparation.
2, test method:
With reference to the test method of " Chinese Pharmacopoeia version in 2010 two annex XIXC ", accelerated test is carried out to the chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 preparation.
3, result of the test:
Result of the test is as table 2.
The accelerated test result of table 2 chitosan oligosaccharide capsule agent
As shown in Table 2, chitosan oligosaccharide capsule agent prepared by embodiment of the present invention 1-4 temperature be 40 DEG C ± 2 DEG C, relative humidity be the condition of 75% ± 5% under place 6 months, its indices all meets the prescription of Chinese Pharmacopoeia to capsule, and the chitosan oligosaccharide capsule agent that the stability of chitosan oligosaccharide capsule agent prepared by comparative example 1 and comparative example 2 is all prepared than embodiment 1-4 is poor, illustrate that chitosan oligosaccharide capsule agent prescription provided by the invention is reasonable, improve the stability of chitosan oligosaccharide capsule agent greatly.
test example three,the long term test of chitosan oligosaccharide capsule agent
1, test material: the chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3 and embodiment 4 preparation.
2, test method:
With reference to the test method of " Chinese Pharmacopoeia version in 2010 two annex XIXC ", long term test is carried out to the chitosan oligosaccharide capsule agent of embodiment 1, embodiment 2, embodiment 3 and embodiment 4 preparation.
3, result of the test:
Result of the test is as table 3.
The long-term test results of table 3 chitosan oligosaccharide capsule agent
As shown in Table 3, chitosan oligosaccharide capsule agent prepared by embodiment of the present invention 1-4 temperature be 25 DEG C ± 2 DEG C, relative humidity be the condition of 60% ± 10% under place 12 months, its indices all meets the prescription of Chinese Pharmacopoeia to capsule, illustrate that capsule stability provided by the invention is high, moisture effect is good, is conducive to the preservation of this capsule.
Claims (10)
1. a chitosan oligosaccharide capsule agent, is characterized in that, comprises content and softgel shell, and described content comprises following component and percentage by weight thereof:
Oligochitosan 80-100%, microcrystalline Cellulose 0-6%, adhesive 0-5%, calcium stearate 0-3%, ethanol 0-4% and micropowder silica gel 0-2%;
Described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 4-10 part, xanthan gum 2-6 part, thickening agent 4-8 part, plasticizer 3-6 part and water 10-20 part.
2. chitosan oligosaccharide capsule agent as claimed in claim 1, it is characterized in that, described content comprises following component and percentage by weight thereof:
Oligochitosan 80-92%, microcrystalline Cellulose 2-6%, adhesive 2-5%, calcium stearate 1-3%, ethanol 2-4% and micropowder silica gel 1-2%.
3. chitosan oligosaccharide capsule agent as claimed in claim 2, it is characterized in that, described content comprises following component and percentage by weight thereof:
Oligochitosan 85.5%, microcrystalline Cellulose 4%, adhesive 4%, calcium stearate 2%, ethanol 3% and micropowder silica gel 1.5%.
4. the chitosan oligosaccharide capsule agent as described in as arbitrary in claim 1-3, is characterized in that, described adhesive to be concentration be 5% povidone solution, described ethanol is dehydrated alcohol.
5. chitosan oligosaccharide capsule agent as claimed in claim 1, it is characterized in that, described softgel shell comprises following component and parts by weight thereof:
Hydroxypropyl starch 8 parts, xanthan gum 4 parts, thickening agent 5 parts, plasticizer 4 parts and 16 parts, water.
6. the chitosan oligosaccharide capsule agent as described in claim 1 or 5, is characterized in that, described thickening agent is made up of by weight 1-2:3-4 guar gum and propylene glycol alginate.
7. chitosan oligosaccharide capsule agent as claimed in claim 6, is characterized in that, described thickening agent is made up of by weight 1.2:3.5 guar gum and propylene glycol alginate.
8. the chitosan oligosaccharide capsule agent as described in claim 1 or 5, is characterized in that, described plasticizer is made up of by weight 2-4:1-3 glycerol and triethyl citrate.
9. chitosan oligosaccharide capsule agent as claimed in claim 6, is characterized in that, described plasticizer is made up of by weight 3.5:2 glycerol and triethyl citrate.
10. a preparation method for the chitosan oligosaccharide capsule agent as described in as arbitrary in claim 1-9, is characterized in that, comprise the following steps:
Oligochitosan, microcrystalline Cellulose, calcium stearate and micropowder silica gel are ground to form fine powder by S1, add adhesive and ethanol mix homogeneously, cross 18-25 mesh sieve, obtain fine powder;
The fine powder that step S1 obtains by S2 carries out wet granulation, and the temperature of described wet granulation is 22-28 DEG C, and humidity is 35-45%, is dried to moisture and is less than 10%, obtain content after granulation;
Hydroxypropyl starch is ground to form fine powder by S3, adds xanthan gum, thickening agent, plasticizer and water mix homogeneously, is dry 4-5h under the condition of 55-60 DEG C, then carries out dipping in glue at temperature is 50 DEG C in temperature, dries, the demoulding, cutting, and fit, obtains softgel shell;
The content that step S2 obtains by S4 is filled in the softgel shell that step S3 obtains, and is sealed by capsule, to obtain final product.
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| CN201510988017.7A CN105380924B (en) | 2015-12-24 | 2015-12-24 | A kind of chitosan oligosaccharide capsule agent and preparation method thereof |
| PCT/CN2016/102114 WO2017107628A1 (en) | 2015-12-24 | 2016-10-14 | Chitosan oligosaccharide capsule and method for preparation thereof |
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| WO2017107628A1 (en) * | 2015-12-24 | 2017-06-29 | 广东药科大学 | Chitosan oligosaccharide capsule and method for preparation thereof |
| CN108186701A (en) * | 2018-02-08 | 2018-06-22 | 沈勇子 | A kind of chitosan oligosaccharide capsule and preparation method thereof |
| CN108553426A (en) * | 2018-06-01 | 2018-09-21 | 广东药科大学 | A kind of chitosan dripping pill and preparation method thereof |
| CN108578374A (en) * | 2018-06-01 | 2018-09-28 | 广东药科大学 | A kind of chitosan oligosaccharide granule and preparation method thereof |
| CN109316460A (en) * | 2018-09-26 | 2019-02-12 | 青岛大学 | A kind of preparation method of polysaccharide polyelectrolyte hollow capsules and obtained hollow capsules |
| CN114376982A (en) * | 2022-01-18 | 2022-04-22 | 广东药科大学 | Chitosan oligosaccharide enteric capsule and preparation method and application thereof |
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| WO2022194351A1 (en) | 2021-03-16 | 2022-09-22 | Symrise Ag | Active substance capsules |
| CN115212189A (en) * | 2022-03-30 | 2022-10-21 | 江南大学 | Nano-microsphere for improving oral bioavailability of chitosan oligosaccharide and preparation method thereof |
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| CN105380924B (en) * | 2015-12-24 | 2018-01-16 | 广东药科大学 | A kind of chitosan oligosaccharide capsule agent and preparation method thereof |
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| US20060292212A1 (en) * | 2002-12-16 | 2006-12-28 | Laurence Paris | Use of thickening agents for producing soft capsules and film production method |
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| WO2017107628A1 (en) * | 2015-12-24 | 2017-06-29 | 广东药科大学 | Chitosan oligosaccharide capsule and method for preparation thereof |
| CN108186701A (en) * | 2018-02-08 | 2018-06-22 | 沈勇子 | A kind of chitosan oligosaccharide capsule and preparation method thereof |
| CN108553426A (en) * | 2018-06-01 | 2018-09-21 | 广东药科大学 | A kind of chitosan dripping pill and preparation method thereof |
| CN108578374A (en) * | 2018-06-01 | 2018-09-28 | 广东药科大学 | A kind of chitosan oligosaccharide granule and preparation method thereof |
| CN108578374B (en) * | 2018-06-01 | 2020-04-03 | 广东药科大学 | Chitosan oligosaccharide granules and preparation method thereof |
| CN108553426B (en) * | 2018-06-01 | 2020-04-03 | 广东药科大学 | Chitosan dropping pill and preparation method thereof |
| CN109316460A (en) * | 2018-09-26 | 2019-02-12 | 青岛大学 | A kind of preparation method of polysaccharide polyelectrolyte hollow capsules and obtained hollow capsules |
| CN109316460B (en) * | 2018-09-26 | 2021-11-26 | 青岛大学 | Preparation method of polysaccharide polyelectrolyte hollow capsule and hollow capsule obtained by preparation method |
| CN114376982A (en) * | 2022-01-18 | 2022-04-22 | 广东药科大学 | Chitosan oligosaccharide enteric capsule and preparation method and application thereof |
| WO2023138172A1 (en) * | 2022-01-18 | 2023-07-27 | 广东药科大学 | Chitosan oligosaccharide enteric capsule, and preparation method therefor and use thereof |
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| Publication number | Publication date |
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| CN105380924B (en) | 2018-01-16 |
| WO2017107628A1 (en) | 2017-06-29 |
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