CN109125285A - A kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof - Google Patents
A kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof Download PDFInfo
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- CN109125285A CN109125285A CN201811234376.3A CN201811234376A CN109125285A CN 109125285 A CN109125285 A CN 109125285A CN 201811234376 A CN201811234376 A CN 201811234376A CN 109125285 A CN109125285 A CN 109125285A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The invention discloses a kind of algal polysaccharides Capsules soluble in the stomach, it is related to algal polysaccharides applied technical field, including raw material by: colloid, hydroxymethyl starch, water-soluble cross-linked starch, plasticizer, colorant and the titanium dioxide that carragheen and/or agar-agar form also disclose the preparation method of the algal polysaccharides Capsules soluble in the stomach.The beneficial effects of the invention are as follows, the ingredient of the algal polysaccharides Capsules soluble in the stomach is reasonable, production method simple possible, manufactured finished capsule product is easy to be disintegrated under simulate the gastric juice environment, easily by Gastric juice digestion, the algal polysaccharides Capsules soluble in the stomach can be used for drug effect in certain drug stomach and discharge, and have a good application prospect in terms of drug release.
Description
Technical field
The present invention relates to algal polysaccharides technical field more particularly to a kind of algal polysaccharides Capsules soluble in the stomach and its preparation sides
Method.
Background technique
Algal polysaccharides are a kind of multi-component mixtures.Up to now, it is focused primarily upon to the research of its structure to be wrapped
The sugar unit and content contained.
Algal polysaccharides are mainly from kelp, deer's tail dish (sargassum fusifome), bulk kelp, yellow tang, bladder-wrack, asparagus, Eucheuma
Equal seaweed.Algal polysaccharides mainly include algin, furcellaran, fucoidin and laminaran.It is isolated brown from kelp
Phycocolloid, fucoidin and laminaran crude product are the powder of white yellowish.Purified obtained sodium alginate is white
Filiform；Fucoidin is off-white powder；The two is dissolved in water, insoluble in organic solvents such as ethyl alcohol, acetone, chloroforms.Red algae
The character of glue (9000-21-9): its white in appearance is powdered to light yellowish brown, odorless, taste is micro- salty；It is soluble in 75~77 DEG C
Water, milk form solid, smooth, flexible gel, and viscosity is most when 37 DEG C of generation viscosity, 43 DEG C for 1.5% aqueous dispersions
It greatly, is more than that then viscosity reduces this temperature；As agar, even if pressurization a few hours, quality also do not reduce, gel and agar one
Sample is hard, stronger than carragheen；Gel strength increases in the presence of potassium ion, and gel strength is different because of pH, highest when pH8, in low pH
Region heating then reduces, and does not dissolve in ethyl alcohol.
Algal polysaccharides have the effects that antiviral and antitumor, anti-mutation, anti-radiation and strengthen immunity.In medical applications
Aspect has a extensive future.
Algal polysaccharides Capsules are originated from pure plant, do not contain animal component, and both there is no rabid ox disease, aftosas etc.
The potential threat of animal epidemic disease source disease, the problem of also residual without antibiotic, feed addictive etc. in animal body.Content of beary metal side
Face has also prevented a possibility that external chromium source pollutes because not using gelatin material completely.Algal polysaccharides Capsules are without micro-
Biological growth breeds necessary nitrogen source, therefore product, without adding preservative, there are also certain self-purification functions.
The main capsule material of algal polysaccharides Capsules is the plant polyose extracted from seaweed, the superior function of physicochemical property
Overcome and avoid the defect of gelatin.Algal polysaccharides Capsules water content is low, can keep excellent physical below 8%
Can, far below the water demand of gelatin hollow capsule about 15%.Algal polysaccharides Capsules are both not easy to shift itself moisture, also not
Easily absorb the drug moisture, moreover it is possible to effectively inhibit the entrance of extraneous steam, to ensure that drug does not go bad because of the moisture absorption, water suction.
Algal polysaccharides Capsules physical property is superior, good toughness, and intensity is high, and easy-weathering and friability, do not fill drug
Operating condition is more relaxed, and 48 months validity periods were longer than gelatine capsule (usual 9-12 months).In course of dissolution, seaweed
Polysaccharide empty capsule will not water swelling, avoid patient from generating abdomen turgors, loss of appetite because of a large amount of medications；And gelatine capsule is molten
Itself 5-10 times of water is can absorb in solution.
Algal polysaccharides Capsules have chemical inertness, will not crosslink, be condensed etc. with filling drug and react, can be effective
Guarantee disintegration, dissolution and the bioavilability of capsule；And gelatine capsule is due to its capsule material category protein matter, containing amino,
Carboxyl isoreactivity group will lead to the rotten discoloration of drug, influence curative effect of medication after reacting with some drugs.
Algal polysaccharides as drug and pharmaceutical intermediate, have reducing blood lipid, it is anti-oxidant, hypoglycemic, antitumor, antiviral,
The effects of anti-mutation, anti-radiation and strengthen immunity；As a kind of efficient biological adsorption agent, the phagocytosis energy of haemocyte can be improved
Power, the active effect that also improves to lysozyme.
Algal polysaccharides capsule is applied to gastrointestinal drug release aspect report currently, rarely having.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof.
To achieve the above object, the present invention adopts the following technical solutions:
A kind of algal polysaccharides Capsules soluble in the stomach, including following raw material:
2-35 parts of colloid；
5-20 parts of hydroxymethyl starch；
Water-soluble cross-linked starch 50-75 parts；
2-3 parts of plasticizer；
0-0.05 parts of colorant；
0-5 parts of titanium dioxide.
Further, a kind of algal polysaccharides Capsules soluble in the stomach, including following raw material:
5-30 parts of colloid；
6-18 parts of hydroxymethyl starch；
Water-soluble cross-linked starch 45-70 parts；
2-3 parts of plasticizer；
0.01-0.05 parts of colorant；
1-5 parts of titanium dioxide.
Further, the colloid is carragheen and/or agar-agar, and the dosage of carragheen and agar-agar is arbitrary proportion.
Further, 20 DEG C when concentration be 1wt% the viscosity of colloid aqueous solution be 3-7mPa.s.
Further, the water-soluble cross-linked starch is selected from corn soluble starch, potato soluble starch and malt
One of dextrin is a variety of.
Further, the plasticizer selects glycerol, and the colorant selects edible pigment.
A kind of preparation method of algal polysaccharides Capsules soluble in the stomach, preparation step are as follows:
(1) ingredient
Colloid made by the carragheen of arbitrary proportion, agar-agar is added into suitable pure water, is stirred in glue pot, is stirred
Successively hydroxymethyl starch, water-soluble cross-linked starch is added in sequence in the process；
(2) colloidal sol
It by above-mentioned ingredient at a temperature of 80-95 DEG C, stirs 3-4 hours, glycerol, edible pigment and two is added in whipping process
Titanium oxide is completely dissolved, and being configured to mass concentration is 12-16% glue；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, heat preservation stands 2- at a temperature of 65-85 DEG C
After for 24 hours, the foam on surface is removed, after supporting glue, gelatin viscosity reaches 2000-3000mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 20-25 DEG C, humidity 50-65%, select the capsule die of suitable model in glue
Glue is dipped in, glue is uniformly distributed；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 25-40 DEG C, hot-air seasoning time 1-1.5h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, is made one
A finished capsule product；
(8) finished product is detected
The detection that quality, moisture are carried out to finished capsule product, to detection, qualified finished capsule product is dispensed.
Further, in step 3, at the end of supporting glue process, the viscosity of glue is 2200-2600mPa.s.
Further, in step 8, the moisture of manufactured finished capsule product is less than 8%.
The invention has the advantages that the ingredient of the algal polysaccharides Capsules soluble in the stomach is reasonable, production method simple possible,
Manufactured finished capsule product is easy to be disintegrated under simulate the gastric juice environment, easily by Gastric juice digestion, the algal polysaccharides Capsules soluble in the stomach
It can be used for drug effect in certain drug stomach to discharge, be had a good application prospect in terms of drug release.
Detailed description of the invention
Fig. 1 is present invention process flow diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on this
Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts
Example is applied, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of preparation method of algal polysaccharides Capsules soluble in the stomach, preparation step are as follows:
(1) ingredient
By colloid 10g made by the carragheen of weight ratio 1:1, agar-agar, adds suitable pure water, stirred in glue pot
It mixes, successively hydroxymethyl starch 15g, corn soluble starch 60g is added in sequence in whipping process；
(2) colloidal sol
By above-mentioned ingredient at a temperature of 90 DEG C, stir 3 hours, in whipping process add glycerol 2g, edible pigment 0.05g and
Titanium dioxide 2g, being completely dissolved and being configured to concentration is 13% glue；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, after heat preservation stands 10h at a temperature of 70 DEG C,
The foam on surface is removed, after supporting glue, gelatin viscosity reaches 2500mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 20 DEG C, humidity 55%, the capsule die of suitable model is selected to dip in glue in glue,
It is uniformly distributed glue；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 30 DEG C, hot-air seasoning time 1h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, is made one
A finished capsule product；
(8) finished product is detected
Quality, water content detection, the moisture 6% of manufactured finished capsule product, the finished product qualified to detection are carried out to finished capsule product
Capsule is dispensed.
Embodiment 2
A kind of preparation method of algal polysaccharides Capsules soluble in the stomach, preparation step are as follows:
(1) ingredient
By colloid 30g made by the carragheen of weight ratio 3:2, agar-agar, adds suitable pure water, stirred in glue pot
It mixes, successively hydroxymethyl starch 20g, corn soluble starch 20g, potato soluble starch 50g is added in sequence in whipping process；
(2) colloidal sol
It by above-mentioned ingredient at a temperature of 95 DEG C, stirs 3 hours, glycerol 3g and titanium dioxide 4g is added in whipping process, it is complete
It is 15% glue that fully dissolved, which is configured to concentration,；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, after heat preservation stands 20h at a temperature of 80 DEG C,
The foam on surface is removed, after supporting glue, gelatin viscosity reaches 2300mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 20 DEG C, humidity 50%, the capsule die of suitable model is selected to dip in glue in glue,
It is uniformly distributed glue；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 25 DEG C, hot-air seasoning time 1.5h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, is made one
A finished capsule product；
(8) finished product is detected
Quality, water content detection, the moisture 5% of manufactured finished capsule product, the finished product qualified to detection are carried out to finished capsule product
Capsule is dispensed.
Embodiment 3
A kind of preparation method of algal polysaccharides Capsules soluble in the stomach, preparation step are as follows:
(1) ingredient
By glue 5g made by the carragheen of weight ratio 1:2, agar-agar, adds suitable pure water, stirred in glue pot, stirred
Successively hydroxymethyl starch 5g, maltodextrin 50g is added in sequence during mixing；
(2) colloidal sol
By above-mentioned ingredient at a temperature of 80 DEG C, stir 4 hours, in whipping process add glycerol 3g, edible pigment 0.03g and
Titanium dioxide 3g, being completely dissolved and being configured to concentration is 12% glue；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, after heat preservation is stood for 24 hours at a temperature of 65 DEG C,
The foam on surface is removed, after supporting glue, gelatin viscosity reaches 2200mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 25 DEG C, humidity 50%, the capsule die of suitable model is selected to dip in glue in glue,
It is uniformly distributed glue；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 40 DEG C, hot-air seasoning time 1h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, is made one
A finished capsule product；
(8) finished product is detected
Quality, water content detection, the moisture 3% of manufactured finished capsule product, the finished product qualified to detection are carried out to finished capsule product
Capsule is dispensed.
Embodiment 4
A kind of preparation method of algal polysaccharides Capsules soluble in the stomach, preparation step are as follows:
(1) ingredient
By glue 25g made by the carragheen of weight ratio 10:3, agar-agar, adds suitable pure water, is stirred in glue pot,
Successively hydroxymethyl starch 15g, corn soluble starch 20g, potato soluble starch 30g and wheat is added in sequence in whipping process
Bud dextrin 20g；
(2) colloidal sol
It by above-mentioned ingredient at a temperature of 95 DEG C, stirs 3 hours, glycerol 2.5g, edible pigment 0.01g is added in whipping process
With titanium dioxide 1g, being completely dissolved and being configured to concentration is 14% glue；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, after heat preservation stands 10h at a temperature of 70 DEG C,
The foam on surface is removed, after supporting glue, gelatin viscosity reaches 2400mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 20 DEG C, humidity 55%, the capsule die of suitable model is selected to dip in glue in glue,
It is uniformly distributed glue；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 30 DEG C, hot-air seasoning time 1h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, is made one
A finished capsule product；
(8) finished product is detected
Quality, water content detection, the moisture 7% of manufactured finished capsule product, the finished product qualified to detection are carried out to finished capsule product
Capsule is dispensed.
Disintegration of the finished capsule product in the detection method soluble in the stomach reference " Chinese Pharmacopoeia " 2015 editions the 4th in simulate the gastric juice
Time limit part.
The experimentation and test data of above-described embodiment are as shown in the table:
It can be seen that using algal polysaccharides soluble in the stomach Capsules made by the method for the present invention, in simulation gastric environment very
It is easy to be digested, can be all disintegrated in 10 minutes under one's belt, therefore, which can be used for certain drug
Drug effect discharges in stomach, has a extensive future.
Certainly, the above description is not a limitation of the present invention, and the present invention is also not limited to the example above, this technology neck
The variations, modifications, additions or substitutions that the technical staff in domain is made within the essential scope of the present invention also should belong to of the invention
Protection scope.
Claims (9)
1. a kind of algal polysaccharides Capsules soluble in the stomach, which is characterized in that including following raw material:
2-35 parts of colloid；
5-20 parts of hydroxymethyl starch；
Water-soluble cross-linked starch 50-75 parts；
2-3 parts of plasticizer；
0-0.05 parts of colorant；
0-5 parts of titanium dioxide.
2. a kind of algal polysaccharides Capsules soluble in the stomach as described in claim 1, which is characterized in that former including following parts by weight
Material:
5-30 parts of colloid；
6-18 parts of hydroxymethyl starch；
Water-soluble cross-linked starch 45-70 parts；
2-3 parts of plasticizer；
0.01-0.05 parts of colorant；
1-5 parts of titanium dioxide.
3. a kind of algal polysaccharides Capsules soluble in the stomach as claimed in claim 2, which is characterized in that the colloid is carragheen
And/or agar-agar, and the dosage of carragheen and agar-agar is arbitrary proportion.
4. a kind of algal polysaccharides Capsules soluble in the stomach as claimed in claim 2, which is characterized in that concentration is 1wt% at 20 DEG C
Colloid aqueous solution viscosity be 3-7mPa.s.
5. a kind of algal polysaccharides Capsules soluble in the stomach as claimed in claim 2, which is characterized in that the water-soluble cross-linked starch
Selected from one of corn soluble starch, potato soluble starch and maltodextrin or a variety of.
6. a kind of algal polysaccharides Capsules soluble in the stomach as claimed in claim 2, which is characterized in that the plasticizer is selected sweet
Oil, colorant select edible pigment.
7. the preparation method of the algal polysaccharides Capsules soluble in the stomach as described in any in claim 2-6, which is characterized in that preparation
Steps are as follows:
(1) ingredient
Colloid made by the carragheen of arbitrary proportion, agar-agar is added into suitable pure water, is stirred in glue pot, whipping process
In successively sequence be added hydroxymethyl starch, water-soluble cross-linked starch；
(2) colloidal sol
It by above-mentioned ingredient at a temperature of 80-95 DEG C, stirs 3-4 hours, glycerol, edible pigment and titanium dioxide is added in whipping process
Titanium is completely dissolved, and being configured to mass concentration is 12-16% glue；
(3) glue is supported
After mixing evenly, it is transferred in automatic temperature-controlled stainless steel barrel and support glue, after heat preservation stands 2-24h at a temperature of 65-85 DEG C,
The foam on surface is removed, after supporting glue, gelatin viscosity reaches 2000-3000mPa.s；
(4) glue is dipped in
After the completion of supporting glue, under the conditions of 20-25 DEG C, humidity 50-65%, the capsule die of suitable model is selected to dip in glue
Glue is uniformly distributed glue；
(5) it dries
After dipping in glue, dried to the mold after glue is dipped in, at a temperature of 25-40 DEG C, hot-air seasoning time 1-1.5h；
(6) cooling
It is placed into after drying in the stabilization case of 25 DEG C of temperature, relative humidity 55% and balances cooling 30min；
(7) it demoulds, cut, fitting
Capsule after cooling is detached from from mold, is then cut, together by two capsule hemisphere fittings, be made one at
Product capsule；
(8) finished product is detected
Quality, water content detection are carried out to finished capsule product, qualified finished capsule product dispenses to detection.
8. the preparation method of algal polysaccharides Capsules soluble in the stomach as claimed in claim 7, which is characterized in that in step 3, support glue
At the end of process, the viscosity of glue is 2200-2600mPa.s.
9. the preparation method of algal polysaccharides Capsules soluble in the stomach as claimed in claim 7, which is characterized in that in step 8, be made
Finished capsule product moisture less than 8%.
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| CN201811234376.3A CN109125285A (en) | 2018-10-23 | 2018-10-23 | A kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112754047A (en) * | 2020-10-09 | 2021-05-07 | 王有平 | Preparation method of hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsules |
| CN113841891A (en) * | 2021-09-17 | 2021-12-28 | 江苏食品药品职业技术学院 | Food nutrient and preparation method thereof |
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| CN1903157A (en) * | 2005-07-26 | 2007-01-31 | 黄族和 | Method for producing hollow capsules dissoluble in stomach by using seaweed polysaccharide as raw material |
| CN106138008A (en) * | 2016-07-12 | 2016-11-23 | 佛山杰致信息科技有限公司 | Vegetative hard capsule and preparation method thereof |
| KR20180097013A (en) * | 2017-02-22 | 2018-08-30 | 농업회사법인(주)강림오가닉 | A agar soft capsules method |
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- 2018-10-23 CN CN201811234376.3A patent/CN109125285A/en active Pending
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| CN1903157A (en) * | 2005-07-26 | 2007-01-31 | 黄族和 | Method for producing hollow capsules dissoluble in stomach by using seaweed polysaccharide as raw material |
| CN106138008A (en) * | 2016-07-12 | 2016-11-23 | 佛山杰致信息科技有限公司 | Vegetative hard capsule and preparation method thereof |
| KR20180097013A (en) * | 2017-02-22 | 2018-08-30 | 농업회사법인(주)강림오가닉 | A agar soft capsules method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112754047A (en) * | 2020-10-09 | 2021-05-07 | 王有平 | Preparation method of hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsules |
| CN113841891A (en) * | 2021-09-17 | 2021-12-28 | 江苏食品药品职业技术学院 | Food nutrient and preparation method thereof |
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Application publication date: 20190104 |