CN106138008A - Vegetative hard capsule and preparation method thereof - Google Patents
Vegetative hard capsule and preparation method thereof Download PDFInfo
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- CN106138008A CN106138008A CN201610556632.5A CN201610556632A CN106138008A CN 106138008 A CN106138008 A CN 106138008A CN 201610556632 A CN201610556632 A CN 201610556632A CN 106138008 A CN106138008 A CN 106138008A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The invention discloses a kind of vegetative hard capsule, be made up of with water following component；The deformation starch of 20～30 weight portions, one or more in the agar of 30～50 weight portions, pectin, carrageenan and Sargassum sodium silicate, the glycerol of 8～18 weight portions；Described water accounts for the 4～7% of vegetative hard capsule gross weight.The present invention is by selecting deformation starch, and in agar, pectin, carrageenan and Sargassum sodium silicate one or both, glycerol, and limit the consumption of above-mentioned raw materials, and then obtain the vegetative hard capsule that stability is high, and above-mentioned raw materials low cost, and then vegetative hard capsule cost of manufacture can be reduced.
Description
Technical field
The present invention relates to hard capsule field, particularly relate to a kind of vegetative hard capsule and preparation method thereof.
Background technology
Hard capsule refers to that a certain amount of medicinal substances extract is added medicated powder or adjuvant makes uniform powder or granule, is filled in
Capsules is made, or medicinal powder direct packaging is made in Capsules.At present, the capsule product 90% on market
More than use gelatin as capsule shell material.Gelatin is by the collagen partial hydrolysis in the animal skeleton such as pig, cattle, skin, tendon
After, purify the protein articles obtained.Although gelatin has excellent characteristics when preparing hard capsule, but gelatin is as allos egg
White matter may have antigenicity, and the cattle source property gelatin materials such as import may contain Protein virus, and using it is that raw material prepares
Hard capsule may cause the diffusion of bovine spongiform encephalopathy.Especially, at the beginning of 2012 domestic " toxic capsule " event exposed by gelatine capsule
Pull abnormal unprecedented trust crisis into.Therefore, the vegetative hard capsule casing of exploitation non-animal replaces gelatin to have non-
The most wide application prospect.
In recent years, the most defined with cellulose esters (such as hydroxypropyl methylcellulose etc.) and vegetable polysaccharides (such as general Shandong
Blue sugar, alginic acid, carrageenan and agar etc.) be the novel plant hard capsule product of raw material, current year sales volume reach 10,000,000,000 left sides
The right side, and with the speed increment of annual 20%～30%.
Although the advantage of vegetative hard capsule has been reached common understanding, but due to about 3 times that its price is gelatin,
High production cost constrains the further genralrlization of vegetative hard capsule and uses.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of vegetative hard capsule and preparation method thereof, this vegetative hard
Capsule low cost.
To achieve these goals, the technical scheme is that
A kind of vegetative hard capsule, is made up of with water following component；The deformation starch of 20～30 weight portions, 30～50 weight
One or more in agar, pectin, carrageenan and the Sargassum sodium silicate of part, the glycerol of 8～18 weight portions；Described water accounts for plant
The 4～7% of property hard capsule gross weight.
Preferably, described deformation starch is vinegar ester starch, hydroxymethyl starch, acidified starch or Oxytarch.
Preferably, also include that reinforcing agent, the parts by weight of described reinforcing agent are 0.5～1.5 part.
Preferably, one or both during described reinforcing agent is dipotassium hydrogen phosphate, potassium dihydrogen phosphate.
Preferably, described reinforcing agent is dipotassium hydrogen phosphate and potassium dihydrogen phosphate, described dipotassium hydrogen phosphate and potassium dihydrogen phosphate
Mass ratio be 1～3:4～6.
Preferably, also include that auxiliary agent, the parts by weight of described auxiliary agent are 1～3 part.
Preferably, one or more during described auxiliary agent is sodium citrate, potassium citrate or potassium chloride.
Present invention also offers the preparation method of a kind of vegetative hard capsule, comprise the following steps:
A) the deformation starch of 20～30 weight portions is dissolved in the glycerol of water and 8～18 weight portions, obtains the first mixed liquor；
The parts by weight of described water are 50～80 parts；
B) in the mixed liquor that step a) obtains, the agar of 30～50 weight portions, pectin, carrageenan and Sargassum silicic acid are added
One or both in sodium, and stir at 65～80 DEG C, obtain glue；
C) glue obtained by step b), with dipping in glue method or pressing prepares vegetative hard capsule casing；
D) vegetative hard capsule casing obtained by step c) is through 30～50 DEG C of drying, obtains the plant that water content is 4～7%
Property hard capsule.
Preferably, step a) also includes: add the reinforcing agent of 0.5～1.5 weight portions.
Preferably, the monodispersity index of glue described in step b) is less than 1.05.
Preferably, step c) also includes, in described glue, add the auxiliary agent of 1～3 weight portions.
From technique scheme it can be seen that the present invention is by selecting deformation starch, and agar, pectin, carrageenan and sea
In algae sodium silicate one or both, glycerol, and limit the consumption of above-mentioned raw materials, and then obtain the vegetative hard that stability is high
Capsule, and above-mentioned raw materials low cost, and then the cost of manufacture of vegetative hard capsule can be reduced.
Detailed description of the invention
In order to further appreciate that the present invention, below in conjunction with embodiment, the preferred embodiments of the invention are described, but
Should be appreciated that these describe simply as further illustrating the features and advantages of the present invention rather than to patent requirements of the present invention
Limit.
A kind of vegetative hard capsule, is formed by following component and water；The deformation starch of 20～30 weight portions, 30～50 weight
One or more in agar, pectin, carrageenan and the Sargassum sodium silicate of part, the glycerol of 8～18 weight portions；Described water accounts for plant
The 4～7% of property hard capsule gross mass.
One or more in described deformation starch and agar, pectin, carrageenan and Sargassum sodium silicate have good increasing
Consistence, film property, play the effect of plasticity in vegetative hard capsule.In the present invention, the parts by weight of deformation starch are 20
～30 parts, one or both the parts by weight in agar, pectin, carrageenan and Sargassum sodium silicate are 30～50 parts.At this
In bright embodiment, the parts by weight of deformation starch are 24～26 parts, two in agar, pectin, carrageenan and Sargassum sodium silicate
The parts by weight planted are 35～45 parts.
In an embodiment of the present invention, deformation starch is vinegar ester starch, hydroxymethyl starch, acidified starch or Oxytarch；
In a further embodiment, deformation starch is vinegar ester starch or acidified starch.
Described glycerol, for improving the stability of vegetative hard capsule, improves the water swelling elastomer of hard capsule.In the present invention,
The parts by weight of glycerol are 8～18 parts；In other embodiments of the invention, the parts by weight of glycerol are 12～15 parts.
Described water, as decomposed solution, plays the effect dissolving each raw material, and water accounts for the total matter of vegetative hard capsule in the present invention
The 4～7% of amount.
In order to improve the hot strength of vegetative hard capsule, it is to avoid vegetative hard capsule generation embrittlement, in the reality of the present invention
Executing in example, be also added into reinforcing agent, the parts by weight of reinforcing agent are 0.5～1.5 part；In a further embodiment, reinforcing agent
Parts by weight are 0.8～1.2 part.
In an embodiment of the present invention, one or both during reinforcing agent is dipotassium hydrogen phosphate, potassium dihydrogen phosphate；Additionally
Embodiment in, reinforcing agent be the mass ratio of dipotassium hydrogen phosphate and potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium dihydrogen phosphate be 1～
3:4～6.
In order to shorten the disintegration time of vegetative hard capsule, in an embodiment of the present invention, it is also added into auxiliary agent, auxiliary agent
Parts by weight are 1～3.
In an embodiment of the present invention, auxiliary agent be sodium citrate, potassium citrate or potassium chloride one or more；Other
In embodiment, auxiliary agent is sodium citrate and potassium citrate.
The source of all raw materials is not particularly limited by the present invention, for commercially available.
The invention also discloses the preparation method of a kind of vegetative hard capsule, comprise the following steps:
A) the deformation starch of 20～30 weight portions is dissolved in the glycerol of water and 8～18 weight portions, obtains mixed liquor；Described
The parts by weight of water are 50～80 parts；
B) in the mixed liquor that step a) obtains, the agar of 30～50 weight portions, pectin, carrageenan and Sargassum silicic acid are added
One or both in sodium, and at 65～80 DEG C, grind stirring, obtain glue；
C) glue obtained by step b), with dipping in glue method or pressing prepares vegetative hard capsule casing；
D) vegetative hard capsule casing obtained by step c) is through 30～50 DEG C of drying, obtains the plant that water content is 4～7%
Property hard capsule.
Wherein, deformation starch, glycerol, agar, pectin, carrageenan and Sargassum sodium silicate are the most same as above, the most superfluous at this
State.
The deformation starch of 20～30 weight portions is dissolved in the glycerol of 50～80 weight parts waters and 8～18 weight portions, obtains
Mixed liquor；Dispersion liquid is wherein initially charged deformation starch, adds the one in agar, pectin, carrageenan and Sargassum sodium silicate
Or the purpose of two kinds is, it is simple to dispersed.
The one or two in the agar of 30～50 weight portions, pectin, carrageenan and Sargassum sodium silicate is added in mixed liquor
Kind, and at 65～80 DEG C, grind stirring, obtain glue；The polydispersity index of described glue is less than 1.05.
By sizing material, with dipping in glue method or pressing prepares vegetative hard capsule casing.
Vegetative hard capsule casing, through 30～50 DEG C of drying, obtains the vegetative hard capsule that water content is 4～7%；Vegetalitas
Easy embrittlement when water content is less than 4% in hard capsule, easy softening transform during higher than 7%.
In order to further illustrate the present invention, a kind of vegetative hard capsule of the present invention being provided below in conjunction with embodiment and
Preparation method is described in detail.
Raw material used in following example is commercially available.
Embodiment 1
A) 20g deforms starch, 0.5g dipotassium hydrogen phosphate is dissolved in the glycerol of 50g water and 8g, obtains the first mixed liquor；
B) in the mixed liquor that step a) obtains, add 10g agar and 20g pectin, and at 65 DEG C, grind stirring, obtain
Glue, the monodispersity index of this glue is 1.04；
C) in the glue that step b) obtains, 1g sodium citrate is added, with dipping in glue method or pressing prepares vegetative hard capsule
Shell；
D) vegetative hard capsule casing obtained by step c) is through 30 DEG C of drying, obtains vegetative hard capsule.
Being analyzed the vegetative hard capsule obtained in embodiment 1, obtaining its water content is 4.5%, and this vegetalitas is hard
Capsule at 37 DEG C in 50ml water disintegration time be 6min, hot strength is 61MPa, and thickness is 0.125mm.
Embodiment 2
A) 30g deforms starch, 1.5g potassium dihydrogen phosphate is dissolved in the glycerol of 80g water and 18g, obtains the first mixed liquor；
B) in the mixed liquor that step a) obtains, add 20g carrageenan and 30g pectin, and at 80 DEG C, grind stirring,
To glue, the monodispersity index of this glue is 1.02；
C) in the glue that step b) obtains, 3g potassium citrate is added, with dipping in glue method or pressing prepares vegetative hard capsule
Shell；
D) vegetative hard capsule casing obtained by step c) is through 50 DEG C of drying, obtains vegetative hard capsule.
Being analyzed the vegetative hard capsule obtained in embodiment 2, obtaining its water content is 5%, this vegetative hard
Capsule at 37 DEG C in 50ml water disintegration time be 5.5min, hot strength is 63MPa, and thickness is 0.121mm.
Embodiment 3
A) 24g deforms starch, 0.2g dipotassium hydrogen phosphate and 0.6g potassium dihydrogen phosphate to be dissolved in the glycerol of 60g water and 12g,
Obtain the first mixed liquor；
B) in the mixed liquor that step a) obtains, add 40g carrageenan, and at 70 DEG C, grind stirring, obtain glue, should
The monodispersity index of glue is 1.02；
C) in the glue that step b) obtains, 1g sodium citrate and 1g potassium chloride are added, with dipping in glue method or pressing prepares and plants
Physical property hard capsule case；
D) vegetative hard capsule casing obtained by step c) is through 40 DEG C of drying, obtains vegetative hard capsule.
Being analyzed the vegetative hard capsule obtained in embodiment 3, obtaining its water content is 6.5%, and this vegetalitas is hard
Capsule at 37 DEG C in 50ml water disintegration time be 4.5min, hot strength is 60MPa, and thickness is 0.127mm.
Embodiment 4
A) 26g deforms starch, 0.3g potassium dihydrogen phosphate and 0.6g dipotassium hydrogen phosphate to be dissolved in the glycerol of 70g water and 15g,
Obtain the first mixed liquor；
B) in the mixed liquor that step a) obtains, 10g pectin, 10g carrageenan and 15g Sargassum sodium silicate are added, and at 75 DEG C
Lower grinding is stirred, and obtains glue, and the monodispersity index of this glue is 1.01；
C) in the glue that step b) obtains, 0.5g sodium chloride and 1.5g potassium citrate are added, with dipping in glue method or compacting legal system
Obtain vegetative hard capsule casing；
D) vegetative hard capsule casing obtained by step c) is through 45 DEG C of drying, obtains vegetative hard capsule.
Being analyzed the vegetative hard capsule obtained in embodiment 4, obtaining its water content is 5.5%, and this vegetalitas is hard
Capsule at 37 DEG C in 50ml water disintegration time be 5min, hot strength is 64MPa, and thickness is 0.125mm.
Embodiment 5
A) 25g deforms starch, 0.5g dipotassium hydrogen phosphate and 0.9g potassium dihydrogen phosphate to be dissolved in the glycerol of 65g water and 13g,
Obtain the first mixed liquor；
B) in the mixed liquor that step a) obtains, 10g agar, 10g pectin, 10g carrageenan and 10g Sargassum sodium silicate are added,
And at 70 DEG C, grind stirring, and obtaining glue, the monodispersity index of this glue is 1.01；
C) in the glue that step b) obtains, add 1g sodium citrate, 1g potassium citrate and 1g potassium chloride, with dip in glue method or
Pressing prepares vegetative hard capsule casing；
D) vegetative hard capsule casing obtained by step c) is through 40 DEG C of drying, obtains vegetative hard capsule.
Being analyzed the vegetative hard capsule obtained in embodiment 5, obtaining its water content is 5.5%, and this vegetalitas is hard
Capsule at 37 DEG C in 50ml water disintegration time be 4.5min, hot strength is 62MPa, and thickness is 0.123mm.
Above a kind of vegetative hard capsule that the present invention provides and preparation method thereof is described in detail, herein
Applying specific case to be set forth principle and the embodiment of the present invention, the explanation of above example is only intended to help
Understand method and the core concept thereof of the present invention, it is noted that for those skilled in the art, do not taking off
On the premise of the principle of the invention, it is also possible to the present invention is carried out some improvement and modification, these improve and modification also falls into this
In invention scope of the claims.
Claims (11)
1. a vegetative hard capsule, it is characterised in that be made up of with water following component；The deformation starch of 20～30 weight portions,
One or more in the agar of 30～50 weight portions, pectin, carrageenan and Sargassum sodium silicate, the glycerol of 8～18 weight portions；Institute
State water and account for the 4～7% of vegetative hard capsule gross weight.
2. vegetative hard capsule as claimed in claim 1, it is characterised in that described deformation starch is vinegar ester starch, methylol
Starch, acidified starch or Oxytarch.
3. vegetative hard capsule as claimed in claim 1, it is characterised in that also include reinforcing agent, the weight of described reinforcing agent
Number is 0.5～1.5 part.
4. vegetative hard capsule as claimed in claim 3, it is characterised in that described reinforcing agent is dipotassium hydrogen phosphate, di(2-ethylhexyl)phosphate
One or both in hydrogen potassium.
5. vegetative hard capsule as claimed in claim 3, it is characterised in that described reinforcing agent is dipotassium hydrogen phosphate and di(2-ethylhexyl)phosphate
Hydrogen potassium, the mass ratio of described dipotassium hydrogen phosphate and potassium dihydrogen phosphate is 1～3:4～6.
6. vegetative hard capsule as claimed in claim 1, it is characterised in that also include auxiliary agent, the parts by weight of described auxiliary agent
It it is 1～3 part.
7. vegetative hard capsule as claimed in claim 5, it is characterised in that described auxiliary agent be sodium citrate, potassium citrate or
One or more in potassium chloride.
8. the preparation method of the vegetative hard capsule as described in any one of claim 1～6, it is characterised in that include with
Lower step:
A) the deformation starch of 20～30 weight portions is dissolved in the glycerol of water and 8～18 weight portions, obtains the first mixed liquor；Described
The parts by weight of water are 50～80 parts；
B) add in the agar of 30～50 weight portions, pectin, carrageenan and Sargassum sodium silicate in the mixed liquor that step a) obtains
One or both, and stir at 65～80 DEG C, obtain glue；
C) glue obtained by step b), with dipping in glue method or pressing prepares vegetative hard capsule casing；
D) vegetative hard capsule casing obtained by step c) is through 30～50 DEG C of drying, obtain water content be 4～7% vegetalitas hard
Capsule.
9. preparation method as claimed in claim 7, it is characterised in that also include in step a): add 0.5～1.5 weight portions
Reinforcing agent.
10. preparation method as claimed in claim 7, it is characterised in that described in step b), the monodispersity index of glue is less than
1.05。
11. preparation methoies as claimed in claim 7, it is characterised in that also include in step c), add 1 in described glue
～3 auxiliary agents of weight portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610556632.5A CN106138008A (en) | 2016-07-12 | 2016-07-12 | Vegetative hard capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610556632.5A CN106138008A (en) | 2016-07-12 | 2016-07-12 | Vegetative hard capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN106138008A true CN106138008A (en) | 2016-11-23 |
Family
ID=58059071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201610556632.5A Withdrawn CN106138008A (en) | 2016-07-12 | 2016-07-12 | Vegetative hard capsule and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125285A (en) * | 2018-10-23 | 2019-01-04 | 青岛聚大洋藻业集团有限公司 | A kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof |
| CN109805351A (en) * | 2019-02-03 | 2019-05-28 | 大连工业大学 | A kind of preparation method of the enriched nutrient salt containing type vitamin A microcapsules |
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| 李晓玺等: "不同pH环境对醋酸酯淀粉薄膜结晶结构及降解性能的影响", 《塑料工业》 * |
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| CN109125285A (en) * | 2018-10-23 | 2019-01-04 | 青岛聚大洋藻业集团有限公司 | A kind of algal polysaccharides Capsules soluble in the stomach and preparation method thereof |
| CN109805351A (en) * | 2019-02-03 | 2019-05-28 | 大连工业大学 | A kind of preparation method of the enriched nutrient salt containing type vitamin A microcapsules |
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