CN100382791C - Plant fiber hard capsule envelope and fabrication method thereof - Google Patents
Plant fiber hard capsule envelope and fabrication method thereof Download PDFInfo
- Publication number
- CN100382791C CN100382791C CNB2005100596701A CN200510059670A CN100382791C CN 100382791 C CN100382791 C CN 100382791C CN B2005100596701 A CNB2005100596701 A CN B2005100596701A CN 200510059670 A CN200510059670 A CN 200510059670A CN 100382791 C CN100382791 C CN 100382791C
- Authority
- CN
- China
- Prior art keywords
- glue
- agar
- glycerol
- hydroxypropyl emthylcellulose
- hard capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007902 hard capsule Substances 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000000835 fiber Substances 0.000 title description 7
- 238000004519 manufacturing process Methods 0.000 title description 5
- 239000003292 glue Substances 0.000 claims description 79
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 75
- -1 hydroxypropyl Chemical group 0.000 claims description 29
- 229920001817 Agar Polymers 0.000 claims description 27
- 239000008272 agar Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 22
- 239000002775 capsule Substances 0.000 claims description 19
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 6
- 238000007689 inspection Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 235000010419 agar Nutrition 0.000 description 18
- 239000003814 drug Substances 0.000 description 9
- 239000002390 adhesive tape Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 238000012856 packing Methods 0.000 description 5
- 235000013402 health food Nutrition 0.000 description 4
- 230000000284 resting effect Effects 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Abstract
The present invention provides a hard capsule envelope that is prepared by taking plant source hydroxypropyl methyl cellulose as the principal ingredient. The present invention also provides a method for preparing the hard capsule envelope from the plant source hydroxypropyl methyl cellulose.
Description
Technical field
The present invention relates to medicine and health food packing technique field, particularly, the present invention relates to a kind of hard capsule case that mainly makes, the invention still further relates to the preparation method of this new hard capsule case by the plant source hydroxypropyl emthylcellulose.
Background technology
Hard capsule case is the edibility packaging material of medicine and health food, and it is along with medicine or health food preparation enter digestion together, so its quality and security performance are directly connected to the quality and the security performance of health food and medicine finished product.Present case is that on the one hand, along with improving constantly of living standard, the people use the requirement of aspects such as raw-material quality and security performance also more and more higher to medicinal packaging material; And on the other hand, the domestic and international market rapidly increases the demand of Chinese medicine preparation, makes the hard capsule case market demand with annual 20% speed increase.And the frequent appearance of bovine spongiform encephalopathy and foot and mouth disease in recent years impels people to put forth effort to discover that new, safer raw material prepares hard capsule case.
At present, used raw material mostly is the skin of pig or cattle, the gelatin that bone is made greatly in the capsule shells of capsule preparations both domestic and external.This capsule with the animal sources preparation in use is subjected to many restrictions, the first, the water content of capsule shells is strict, make the capsule friability increase, be unfavorable for the filling of medicine, particularly the moisture of capsule shells easily is filled the thing absorption when some hygroscopicity composition of filling, make that capsule preparations splits easily, fragmentation in storage process, influenced product quality.The second, gelatine capsule shell needs certain constant temperature, isoperibol to store, the easy softening transform of the too high capsule of temperature, and temperature is crossed low crisp broken easily again.
Adopt natural plant fibre be primary raw material to prepare the medicinal hard capsule shell be emerging research focus of 21st century, the capsule shells that it can replace animal glue to make is widely used in medicine, field of health care food.
Summary of the invention
One of the object of the invention provides a kind of hydroxypropyl emthylcellulose with plant source as primary raw material and the novel hard capsule case that makes as the agar and the glycerol of adjuvant.
Another object of the present invention provides a kind of method for preparing above-mentioned novel hard capsule case.
For achieving the above object, the invention provides following technical scheme:
One of technical scheme of the present invention is for providing a kind of novel plant fiber hard capsule case, comprises as the main component hydroxypropyl emthylcellulose with as the agar and the glycerol of adjuvant.
Technical scheme of the present invention two for a kind of novel plant fiber hard capsule case is provided, comprise as the main component hydroxypropyl emthylcellulose with as agar, glycerol and the titanium dioxide of adjuvant.
According to a kind of embodiment of product of the present invention, by weight, the hydroxypropyl emthylcellulose that described hard capsule case comprises: agar: glycerol is 30-52.5: 1-9: 1-1.5.
A kind of embodiment according to product of the present invention, by weight, the hydroxypropyl emthylcellulose that comprises of described hard capsule case: agar: glycerol: titanium dioxide is a hydroxypropyl emthylcellulose: agar: glycerol: titanium dioxide is 30-52.5: 1-9: 1-1.5: 1: 2.25.
Technical scheme according to the inventive method comprises the steps:
(1) raw material: except that the composition of said hard capsule case, also comprise an amount of water and dehydrated alcohol raw material as the preparation glue;
(2) colloidal sol: standby after earlier 2/3rds of the water yield being heated to 90 ℃, agar is soluble in water, constantly stir until dissolving fully, again hydroxypropyl emthylcellulose is slowly put in the glue pot, constantly stirred, treat that glue temperature reduces to 60 ℃, subsequently with other adjuvants and remaining 1/3rd, temperature is about 60 ℃ hot water and adds in the glue pot, constantly stir, when glue temperature in the glue pot is reduced to 50 ℃, add dehydrated alcohol again, stir;
(3) support glue: with above-mentioned glue place 45 ℃ down insulation quietly put, to remove the bubble of glue; And
(4) be stained with glue: above-mentioned foster good glue is put into be stained with the glue groove, be stained with that the temperature of glue remains in the 32-40 ℃ of scope in the glue groove, indoor environment temperature remains in the 20-28 ℃ of scope, be stained with glue automatically, dry, pull out shell, cutting, fastening, light inspection, sterilization, promptly obtain product through the capsule shells template.
According to a kind of embodiment of the inventive method, by weight, the used hydroxypropyl emthylcellulose of raw material of preparation glue: agar: glycerol: water: dehydrated alcohol is 12-21: 0.4-3.6: 0.4-0.6: 100: 0.79.
According to the another embodiment of the inventive method, by weight, the used hydroxypropyl emthylcellulose of raw material of preparation glue: agar: glycerol: titanium dioxide: water: dehydrated alcohol is 12-21: 0.4-3.6: 0.4-0.6: 0.4-0.9:100: 0.79.
Plant source hydroxypropyl emthylcellulose provided by the invention, it is pharmaceutical grade hydroxypropyl emthylcellulose that can buy, that meet " pharmacopeia " standard on the market.
Other adjuvant agars, glycerol, water, dehydrated alcohol, the titanium dioxide that the present invention relates to is the pharmaceutical grade adjuvant that can buy on the market, meet " pharmacopeia " standard.
The instrument and equipment of the above-mentioned hard capsule case of preparation used in the present invention is the conventional instrument and equipment that uses in this area.
The main innovation gonosome of the technology of the present invention is present:
(1) be edible, the medicinal novel hard capsule case of main material production with the solubility Plant fiber, the product novelty, it adapts to wide, especially can be in great demand Islam and area.
(2) the novel hard capsule case that utilizes above component prescription and method to prepare meets medicine and food fully with requiring, the physical and chemical quality indexes of its product meets the standard of the empty hard softgel shell of country's " pharmacopeia " regulation, and its security performance obviously is better than the hard capsule case product that animal sources glue makes.
(3) hard capsule case that is made by the Plant fiber has stable performance, moisture-proof is good, the antienzyme ability is strong, water content is low, transparency pollution-freely, stored for a long time never degenerates well, natural, scrappy stock is recyclable and recycling, greatly reduce production cost, advantage such as the suitability is wide.
The specific embodiment
Embodiment 1: the transparent adhesive tape softgel shell
The glue prescription of this transparent adhesive tape softgel shell is:
The composition consumption
Hydroxypropyl emthylcellulose 18kg
Agar 0.5kg
Glycerol 0.5kg
Water 100kg
Dehydrated alcohol 0.79kg (1000ml)
Taking by weighing agar 0.5kg, to be dissolved in the 65kg temperature be in 90 ℃ the pure water, constantly stir then until dissolving fully, slowly put into the 18kg hydroxypropyl emthylcellulose in the glue pot again, constantly stir, treat to add when glue temperature is reduced to 60 ℃ 0.5kg glycerol, the hot water that injects the 35kg temperature simultaneously and be 60 ℃ is in glue pot, constantly stir, when reducing to 50 ℃, glue temperature in the glue pot adds dehydrated alcohol 1000ml again, after stirring, place 45 ℃ to be incubated quiet straightening down to removing the glue bubble, the glue of resting is put into and is stained with the glue groove, the temperature of being stained with glue in the glue groove is 34 ℃, indoor environment temperature is 20 ℃, automatically be stained with glue through the capsule shells template, oven dry, pull out shell, cutting, fasten, the light inspection, sterilization, packing promptly obtains product of the present invention.
Embodiment 2: the transparent adhesive tape softgel shell
The prescription of this transparent adhesive tape softgel shell is:
The composition consumption
Hydroxypropyl emthylcellulose 17kg
Agar 1.0kg
Glycerol 0.5kg
Water 100kg
Dehydrated alcohol 0.79kg (1000ml)
Take by weighing agar 1kg and be dissolved in 65kg, temperature is in 90 ℃ the pure water, constantly stir then until dissolving fully, slowly put into the 17kg hydroxypropyl emthylcellulose in the glue pot again, constantly stir, when treating that glue temperature is reduced to 60 ℃, add 0.5kg glycerol and inject 60 ℃ of water of 35kg simultaneously in glue pot, and constantly stir, when reducing to 50 ℃, glue temperature in the glue pot adds dehydrated alcohol 1000ml, after stirring, place 45 ℃ to be incubated quiet straightening down to removing the glue bubble, the glue of resting is put into and is stained with the glue groove, the temperature of being stained with glue in the glue groove is in 35 ℃ of scopes, indoor environment temperature is 22 ℃, is stained with glue automatically through the capsule shells template, oven dry, pull out shell, cutting, fasten, the light inspection, sterilization, packing promptly obtains product of the present invention.
Embodiment 3: the transparent adhesive tape softgel shell
The prescription of this transparent adhesive tape softgel shell is:
The composition consumption
Hydroxypropyl emthylcellulose 16.5kg
Agar 1.5kg
Glycerol 0.5kg
Water 100kg
Dehydrated alcohol 0.79kg (1000ml)
Taking by weighing agar 1.5kg is dissolved in 90 ℃ of hot pure water of 65kg, constantly stir then until dissolving fully, slowly put into the 16.5kg hydroxypropyl emthylcellulose in the glue pot again, constantly stir, when treating that glue temperature is reduced to 60 ℃, add 0.500kg glycerol and inject 60 ℃ of hot water of 35kg simultaneously in glue pot, constantly stir, when reducing to 50 ℃, glue temperature in the glue pot adds dehydrated alcohol 1000ml, after stirring, place 45 ℃ to be incubated quiet straightening down to removing the glue bubble, the glue of resting is put into and is stained with the glue groove, the temperature of being stained with glue in the glue groove is in 37 ℃ of scopes, indoor environment temperature remains on 22 ℃, is stained with glue automatically through the capsule shells template, oven dry, pull out shell, cutting, fasten, the light inspection, sterilization, packing promptly obtains product of the present invention.
Embodiment 4: nontransparent capsule shells
The prescription of this nontransparent capsule shells is:
The composition consumption
Hydroxypropyl emthylcellulose 14kg
Agar 0.5kg
Glycerol 0.5kg
Titanium dioxide 0.8kg
Water 100kg
Dehydrated alcohol 0.79kg (1000ml)
Taking by weighing agar 0.5kg is dissolved in the hot pure water of 90 ℃ of 65kg, constantly stir then until dissolving fully, slowly put into the 14kg hydroxypropyl emthylcellulose in the glue pot again, constantly stir, when treating that glue temperature is reduced to 60 ℃, add 0.5kg glycerol and 0.8kg titanium dioxide, the hot water that injects 35kg60 ℃ simultaneously is in glue pot, constantly stir, when reducing to 50 ℃, glue temperature in the glue pot adds dehydrated alcohol 1000ml, after stirring, place 45 ℃ to be incubated quiet straightening down to removing the glue bubble, the glue of resting is put into and is stained with the glue groove, and the temperature of being stained with glue in the glue groove remains in 38 ℃ of scopes, indoor environment temperature remains in 23 ℃ of scopes is stained with glue automatically through the capsule shells template, oven dry, pull out shell, cutting, fasten, the light inspection, sterilization, packing promptly obtains product of the present invention.
According to hard capsule case of the present invention be the hard capsule case that primary raw material makes with animal gelatin Compare and have following characteristics: be difficult under not yielding under the high temperature, stable chemical performance, the low temperature friability, Water content is low, moisture-proof good, safe and reliable, be fit to filling hygroscopicity medicine; Also has natural nothing Pollute, stored for a long timely never degenerate, the characteristics of disintegration amount limit and friability, meet fully capsule shells proposed Performance requirement; And scrappy stock in process of production is recyclable and recycling, greatly falls Low production cost is the ideal upgrading substitute of traditional animal sources hard capsule case.
Claims (5)
1. hard capsule case, by forming as the plant source hydroxypropyl emthylcellulose of main component with as the agar and the glycerol of adjuvant, its content is:
Hydroxypropyl emthylcellulose 18kg
Agar 0.5kg
Glycerol 0.5kg.
2. hard capsule case, by forming as the plant source hydroxypropyl emthylcellulose of main component with as the agar and the glycerol of adjuvant, its content is:
Hydroxypropyl emthylcellulose 17kg
Agar 1.0kg
Glycerol 0.5kg.
3. hard capsule case, by forming as the plant source hydroxypropyl emthylcellulose of main component with as the agar and the glycerol of adjuvant, its content is:
Hydroxypropyl emthylcellulose 16.5kg
Agar 1.5kg
Glycerol 0.5kg.
4. hard capsule case, by forming as the plant source hydroxypropyl emthylcellulose of main component with as the agar and the glycerol of adjuvant, its content is:
Hydroxypropyl emthylcellulose 14kg
Agar 0.5kg
Glycerol 0.5kg
Titanium dioxide 0.8kg.
5. one kind prepares as the method for hard capsule case as described in any one among the claim 1-4, comprises the steps:
(1) raw material: except that the composition of said hard capsule case, also comprise an amount of water and dehydrated alcohol raw material as the preparation glue;
(2) colloidal sol: standby after earlier 2/3rds of the water yield being heated to 90 ℃, agar is soluble in water, constantly stir until dissolving fully, again hydroxypropyl emthylcellulose is slowly put in the glue pot, constantly stirred, treat that glue temperature reduces to 60 ℃, subsequently with other adjuvants and remaining 1/3rd, temperature is about 60 ℃ hot water and adds in the glue pot, constantly stir, when glue temperature in the glue pot is reduced to 50 ℃, add dehydrated alcohol again, stir;
(3) support glue: with above-mentioned glue place 45 ℃ down insulation quietly put, to remove the bubble of glue; And
(4) be stained with glue: above-mentioned foster good glue is put into be stained with the glue groove, be stained with that the temperature of glue remains in the 32-40 ℃ of scope in the glue groove, indoor environment temperature remains in the 20-28 ℃ of scope, be stained with glue automatically, dry, pull out shell, cutting, fastening, light inspection, sterilization, promptly obtain product through the capsule shells template.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100596701A CN100382791C (en) | 2005-03-31 | 2005-03-31 | Plant fiber hard capsule envelope and fabrication method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100596701A CN100382791C (en) | 2005-03-31 | 2005-03-31 | Plant fiber hard capsule envelope and fabrication method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1839803A CN1839803A (en) | 2006-10-04 |
| CN100382791C true CN100382791C (en) | 2008-04-23 |
Family
ID=37029111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100596701A Active CN100382791C (en) | 2005-03-31 | 2005-03-31 | Plant fiber hard capsule envelope and fabrication method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100382791C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008050209A1 (en) * | 2006-10-27 | 2008-05-02 | Pfizer Products Inc. | Hydroxypropyl methyl cellulose hard capsules and process of manufacture |
| CN103202862B (en) * | 2013-04-27 | 2015-02-04 | 汪振朴 | Capsule shell containing dregs, preparation device of capsule shell, and using method of device |
| CN107296801B (en) * | 2017-08-09 | 2020-03-17 | 安徽黄山胶囊股份有限公司 | Hydroxypropyl methyl cellulose plant empty capsule |
-
2005
- 2005-03-31 CN CNB2005100596701A patent/CN100382791C/en active Active
Non-Patent Citations (2)
| Title |
|---|
| HPMC胶囊壳对干粉吸入剂性能的影响. 汤玥，朱家壁，甘莉.中国药科大学学报，第35卷第1期. 2004 * |
| 药剂学. 毕殿洲，300-301，人民卫生出版社. 2000 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1839803A (en) | 2006-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101167705B (en) | Composition for preparing plant hollow hard capsule and preparation method of capsule | |
| CN102342509B (en) | Konjak polysaccharide compound soft capsule shell and preparation method thereof | |
| CN103783624A (en) | Production method of cloudy Dendrobium officinale functional drink | |
| CN101579326A (en) | Pulullan polysaccharide empty hard capsule and preparation method thereof | |
| CN104436204A (en) | Pullulan polysaccharide capsule and preparation process thereof | |
| CN100382791C (en) | Plant fiber hard capsule envelope and fabrication method thereof | |
| CN1927186A (en) | Formulation of plant source hard capsule case and preparing method thereof | |
| CN106943373A (en) | With cannabidiol soft capsule for improving diabetes effect and preparation method thereof | |
| CN105878208B (en) | A kind of starch base plant medicinal hard capsule forming agent and its application | |
| CN104338142A (en) | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology | |
| CN104337779A (en) | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology | |
| CN103877067B (en) | A kind of Capsules controlling disintegration and preparation method thereof | |
| CN100358510C (en) | Preparation of floridean polysaccharide vegetable prandial fiber medicinal hard capsule | |
| CN102090627B (en) | Artificial sea cucumbers and method for preparing same | |
| CN109125284A (en) | A kind of pullulan polysaccharide hollow hard capasule and preparation method thereof | |
| CN103690510B (en) | A kind of nanometer level cellulose hollow hard capsule and preparation method thereof | |
| CN101919559A (en) | Method for preparing Chinese chestnut beverage | |
| CN101637610A (en) | Carrageenan soft capsule wall material and preparation method thereof | |
| CN103071158A (en) | Bone capsule shell with functions of supplying calcium and building strong bones and preparation method thereof | |
| CN104224745A (en) | A capsule shell of a traditional Chinese medicine soft capsule and a preparing method thereof | |
| CN104338145A (en) | Dropping pill with sodium alginate and gellan gum as capsule wall material, and its production technology | |
| CN104000798A (en) | Vegetative soft capsule | |
| CN106578862A (en) | Instant coix seed powder production method | |
| CN113057945A (en) | Pueraria flower effervescent tablet | |
| CN106666753A (en) | Biological activity high-calcium tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Plant fiber hard capsule envelope and fabrication method thereof Effective date of registration: 20131205 Granted publication date: 20080423 Pledgee: Yantai credit Company Limited by Guarantee Pledgor: Li Renyan Registration number: 2013990000930 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20151015 Granted publication date: 20080423 Pledgee: Yantai financing Company Limited by Guarantee Pledgor: Li Renyan Registration number: 2013990000930 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20151015 Registration number: 2013990000930 Pledgee after: Yantai financing Company Limited by Guarantee Pledgee before: Yantai credit Company Limited by Guarantee |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Plant fiber hard capsule envelope and fabrication method thereof Effective date of registration: 20160111 Granted publication date: 20080423 Pledgee: Industrial Commercial Bank of China Ltd Haiyang branch Pledgor: Li Renyan Registration number: 2016990000016 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170425 Address after: 265100 Shenzhen street, Haiyang Economic Development Zone, Shandong, China, No. 20, No. Patentee after: Yantai Dongfang Shenzhou Biotechnology Co.,Ltd. Address before: 265100 Haiyang Economic Development Zone, Shandong, Shenzhen street, No. 20, No. Patentee before: Li Renyan |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231213 Granted publication date: 20080423 Pledgee: Industrial Commercial Bank of China Ltd Haiyang branch Pledgor: Li Renyan Registration number: 2016990000016 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Plant fiber hard capsule shell and its preparation method Effective date of registration: 20231221 Granted publication date: 20080423 Pledgee: Shandong Haiyang Rural Commercial Bank Co.,Ltd. Pledgor: Yantai Dongfang Shenzhou Biotechnology Co.,Ltd. Registration number: Y2023980073164 |