CN113057945A - Pueraria flower effervescent tablet - Google Patents
Pueraria flower effervescent tablet Download PDFInfo
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- CN113057945A CN113057945A CN202110321974.XA CN202110321974A CN113057945A CN 113057945 A CN113057945 A CN 113057945A CN 202110321974 A CN202110321974 A CN 202110321974A CN 113057945 A CN113057945 A CN 113057945A
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- Prior art keywords
- parts
- effervescent tablet
- pueraria
- extract
- pueraria flower
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- 241000219780 Pueraria Species 0.000 title claims abstract description 54
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 40
- 241000628997 Flos Species 0.000 claims abstract description 21
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 239000000314 lubricant Substances 0.000 claims abstract description 17
- 239000000945 filler Substances 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 15
- 241000219781 Pueraria montana var. lobata Species 0.000 claims abstract description 15
- 239000002253 acid Substances 0.000 claims abstract description 14
- 239000003513 alkali Substances 0.000 claims abstract description 14
- 239000000853 adhesive Substances 0.000 claims abstract description 12
- 230000001070 adhesive effect Effects 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 238000007873 sieving Methods 0.000 claims abstract description 8
- 239000003826 tablet Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 238000002791 soaking Methods 0.000 claims description 35
- 238000001035 drying Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000001704 evaporation Methods 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 11
- 238000005303 weighing Methods 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 230000008020 evaporation Effects 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 7
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 6
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 5
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 229940045872 sodium percarbonate Drugs 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 239000008118 PEG 6000 Substances 0.000 claims description 3
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 3
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 229920003081 Povidone K 30 Polymers 0.000 claims description 2
- 239000004067 bulking agent Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 238000009776 industrial production Methods 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 abstract description 3
- 210000004165 myocardium Anatomy 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 3
- 238000003860 storage Methods 0.000 abstract description 3
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000009747 swallowing Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 12
- 208000007848 Alcoholism Diseases 0.000 description 9
- 201000007930 alcohol dependence Diseases 0.000 description 9
- 229940079593 drug Drugs 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229960004793 sucrose Drugs 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010021113 Hypothermia Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical group C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000021460 special beverage Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
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- Endocrinology (AREA)
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Abstract
The invention discloses a kudzuvine flower effervescent tablet which comprises the following components in parts by weight: 0.05-0.4 part of pueraria flower extract, 1-2.16 parts of acid source, 1-2.16 parts of alkali source, 0.4-2.08 parts of auxiliary disintegrating agent, 0.04-0.24 part of adhesive, 2-4 parts of filler and 0.4 part of lubricant; the preparation method of the kudzuvine flower effervescent tablet comprises the following steps: firstly preparing the pueraria flower extract, then sieving the pueraria flower extract, the disintegrating agent, the adhesive, the filler and the lubricant in parts by weight with a 100-mesh sieve, and finally, uniformly mixing all the components and then putting the mixture into a tablet machine for tabletting. The flos puerariae effervescent tablet provided by the invention is suitable for crowds who drink excessively, injure wine, generate heat and are irritable, and has the effects of protecting liver, enhancing cardiac muscle, reducing blood sugar and blood fat; is especially suitable for children, the elderly and users incapable of swallowing solid preparations, and compared with liquid preparations, the preparation is more convenient for carrying, industrial production, transportation and storage.
Description
Technical Field
The invention belongs to the field of effervescent tablets, and particularly relates to a pueraria flower effervescent tablet.
Background
Wine, as a special beverage, has evolved over the world history for thousands of years. However, alcoholism can be caused by excessive drinking, and light people can have dizziness, nausea, emesis, blurred consciousness, dysmnesia, abnormal mood and somnolence; in severe cases, coma, respiratory depression, hypothermia, and paralysis of breathing may lead to death. In recent years, excessive drinking has been reported to cause esophageal cancer and liver cancer, so that the development of effective anti-hangover drugs has been paid attention from various countries.
The existing anti-alcoholism drugs sold in the domestic market are locally produced and imported, and the price of the imported anti-alcoholism drugs is relatively high; the traditional Chinese medicine has the accumulation of thousands of years, but the sobering medicine which can be researched in modern times has little guidance of the theory of the traditional Chinese medicine, for example, the best choice for sobering up is the flower of kudzuvine, which is recorded by the book of traditional Chinese medicine, has the efficacies of sobering up and enlivening the spleen, and is mainly used for treating alcoholic injury, dysphoria with smothery sensation, thirst, headache and dizziness; modern medical research shows that the pueraria flower can relieve alcoholism, the effective component for relieving alcoholism is isoflavone, and the pueraria root can be used as a raw material of a sold anti-alcoholism medicine. In addition, the types of the anti-alcoholism drugs on the market are many, but most of the anti-alcoholism drugs are canned beverages and are inconvenient to carry.
The effervescent tablet is a new medicament formulation in China, and acid and alkali are mixed to be used as a disintegrating agent. The tablet can be dissolved rapidly after being placed in water, so that the medicine can take effect rapidly. Based on the problems, the invention provides the pueraria flower effervescent tablet which is suitable for crowds who drink too much, hurt wine, generate heat and are irritable, has the effects of protecting liver, strengthening cardiac muscle, reducing blood sugar and blood fat, is particularly suitable for children, old people and users who cannot swallow solid preparations, and is more convenient to carry, lower in production cost, and convenient for industrial production, transportation and storage compared with liquid preparations.
Disclosure of Invention
The invention aims to provide a kudzuvine flower effervescent tablet with an anti-alcoholism effect, which is convenient to carry, low in production cost, convenient to industrially produce, transport and store and is used for solving the problems.
In order to achieve the purpose, the invention adopts the technical scheme that:
the kudzuvine flower effervescent tablet comprises the following components in parts by mass: 0.05 to 0.4 portion of pueraria flower extract, 1 to 2.16 portions of acid source, 1 to 2.16 portions of alkali source, 0.4 to 2.08 portions of auxiliary disintegrating agent, 0.04 to 0.24 portion of adhesive, 2 to 4 portions of filling agent and 0.4 portion of lubricant.
The preparation method of the pueraria flower effervescent tablet comprises the following steps:
s1, soaking: selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min;
s2, warm dipping: putting the pueraria lobata flower obtained in the step S1 and the soaking liquid thereof into a decocting device, putting 8-12 times of water, and stewing for 1-3 times, wherein the time is 1-2 hours each time, and the warm soaking temperature is 60-100 ℃ to obtain a warm soaking liquid;
s3, filtering and concentrating: filtering the warm immersion liquid obtained in the step S2, putting the filtrate into an evaporation system, setting the temperature at 60-70 ℃ and the rotating speed at 40-70 rad/min, evaporating to form a thick extract, and taking out;
s4, drying and crushing: placing the thick extract obtained in the step S3 in drying equipment, and drying at the set temperature of 65-70 ℃ until the dry extract is crushed by a crushing device to obtain a pueraria flower extract for later use;
s5, weighing: weighing 0.05-0.4 part of pueraria flower extract, 1-2.16 parts of acid source, 1-2.16 parts of alkali source, 0.4-2.08 parts of auxiliary disintegrating agent, 0.04-0.24 part of adhesive, 2-4 parts of filler and 0.4 part of lubricant according to the following parts by mass;
s6, pretreatment of raw materials: sieving the flos Puerariae Lobatae extract obtained in step S5, acid source, alkali source, auxiliary disintegrating agent, binder, filler, and lubricant with 100 mesh sieve;
s7, tabletting: and (4) uniformly mixing the pueraria flower extract obtained in the step (S6), a disintegrating agent, an adhesive, a filling agent and a lubricating agent, and then putting the mixture into a tablet machine for tabletting to obtain the pueraria flower effervescent tablet.
Preferably, the acid source is one of glutaric acid, citric acid and tartaric acid; the alkali source is one of sodium bicarbonate, sodium percarbonate and sodium carbonate; the auxiliary disintegrating agent is one of low-substituted hydroxypropyl cellulose and microcrystalline cellulose.
Preferably, the binder is one of polyvinyl alcohol, povidone K30 and sodium carboxymethyl cellulose.
Preferably, the filler is one of mannitol, lactose, sucrose and glucose.
Preferably, the lubricant is one of PEG4000, PEG6000, sodium benzoate and sodium chloride.
The invention has the advantages that:
the pueraria flower effervescent tablet is suitable for crowds who drink too much, injure wine, generate heat and are fidgety, has the functions of protecting liver, strengthening cardiac muscle, reducing blood sugar and blood fat, is particularly suitable for children, old people and users who cannot swallow solid preparations, and is more convenient to carry, lower in production cost, and convenient for industrial production, transportation and storage compared with liquid preparations.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The pueraria flower effervescent tablet provided by the embodiment of the invention comprises the following components in parts by mass: 0.05 to 0.4 portion of pueraria flower extract, 1 to 2.16 portions of acid source, 1 to 2.16 portions of alkali source, 0.4 to 2.08 portions of auxiliary disintegrating agent, 0.04 to 0.24 portion of adhesive, 2 to 4 portions of filling agent and 0.4 portion of lubricant.
In the pueraria flower effervescent tablet provided by the embodiment of the invention, the acid source is one of glutaric acid, citric acid and tartaric acid; the alkali source is one of sodium bicarbonate, sodium percarbonate and sodium carbonate; the auxiliary disintegrating agent is one of low-substituted hydroxypropyl cellulose and microcrystalline cellulose; the adhesive is one of polyvinyl alcohol, polyvidone K30 and sodium carboxymethylcellulose; the filler is one of mannitol, lactose, sucrose and glucose; the lubricant is one of PEG4000, PEG6000, sodium benzoate and sodium chloride.
The preparation method of the pueraria flower effervescent tablet provided by the embodiment of the invention comprises the following steps:
s1, soaking: selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min;
s2, warm dipping: putting the pueraria lobata flower obtained in the step S1 and the soaking liquid thereof into a decocting device, putting 8-12 times of water, and stewing for 1-3 times, wherein the time is 1-2 hours each time, and the warm soaking temperature is 60-100 ℃ to obtain a warm soaking liquid;
s3, filtering and concentrating: filtering the warm immersion liquid obtained in the step S2, putting the filtrate into an evaporation system, setting the temperature at 60-70 ℃ and the rotating speed at 40-70 rad/min, evaporating to form a thick extract, and taking out;
s4, drying and crushing: placing the thick extract obtained in the step S3 in drying equipment, and drying at the set temperature of 65-70 ℃ until the dry extract is crushed by a crushing device to obtain a pueraria flower extract for later use;
s5, weighing: weighing 0.05-0.4 part of pueraria flower extract, 1-2.16 parts of acid source, 1-2.16 parts of alkali source, 0.4-2.08 parts of auxiliary disintegrating agent, 0.04-0.24 part of adhesive, 2-4 parts of filler and 0.4 part of lubricant according to the following parts by mass;
s6, pretreatment of raw materials: sieving the flos Puerariae Lobatae extract obtained in step S5, acid source, alkali source, auxiliary disintegrating agent, binder, filler, and lubricant with 100 mesh sieve;
s7, tabletting: and (4) uniformly mixing the pueraria flower extract obtained in the step (S6), a disintegrating agent, an adhesive, a filling agent and a lubricating agent, and then putting the mixture into a tablet machine for tabletting to obtain the pueraria flower effervescent tablet.
Example 1
1. Preparing a pueraria flower extract:
selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min; placing flos Puerariae Lobatae and its soaking solution in decocting equipment, adding 8 times of water, decocting for 1 time, 1 hr each time, and soaking at 60 deg.C to obtain soaking solution; filtering the obtained warm extract, placing the filtrate in an evaporation system, setting the temperature at 60 ℃ and the rotating speed at 40rad/min, evaporating to obtain a thick extract, and taking out; and (3) placing the obtained thick extract in drying equipment, drying at the set temperature of 65 ℃ until the dry extract is crushed by a crushing device to obtain the pueraria flower extract.
2. The preparation of the kudzuvine flower effervescent tablet comprises the following steps:
weighing 0.05 part of pueraria flower extract, 1 part of glutaric acid, 1 part of sodium bicarbonate, 0.4 part of low-substituted hydroxypropyl cellulose, 0.04 part of polyvinyl alcohol, 2 parts of mannitol and 40000.4 parts of PEG according to the following parts by mass, sieving with a 100-mesh sieve, mixing uniformly, placing in a tabletting machine after mixing, and tabletting to obtain the pueraria flower effervescent tablet.
Example 2
1. Preparing a pueraria flower extract:
selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min; placing flos Puerariae Lobatae and its soaking solution in decocting equipment, adding 8 times of water, decocting for 2 times, each time for 1 hr, and soaking at 80 deg.C to obtain soaking solution; filtering the obtained warm extract, placing the filtrate in an evaporation system, setting the temperature at 60 ℃ and the rotating speed at 40rad/min, evaporating to obtain a thick extract, and taking out; and (3) placing the obtained thick extract in drying equipment, drying at the set temperature of 65 ℃ until the dry extract is crushed by a crushing device to obtain the pueraria flower extract.
2. The preparation of the kudzuvine flower effervescent tablet comprises the following steps:
weighing 0.15 part of pueraria flower extract, 1 part of glutaric acid, 1 part of sodium percarbonate, 1 part of microcrystalline cellulose, 300.1 parts of povidone K, 2 parts of glucose and 60000.4 parts of PEG (polyethylene glycol) according to the following parts by mass, sieving with a 100-mesh sieve, uniformly mixing, putting into a tabletting machine for tabletting, and preparing the pueraria flower effervescent tablet.
Example 3
1. Preparing a pueraria flower extract:
selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min; placing flos Puerariae Lobatae and its soaking solution in decocting equipment, adding 10 times of water, decocting for 3 times, each time for 2 hr, and soaking at 90 deg.C to obtain soaking solution; filtering the obtained warm extract, placing the filtrate in an evaporation system, setting the temperature at 70 ℃ and the rotation speed at 50rad/min, evaporating to obtain a thick extract, and taking out; and (3) placing the obtained thick extract in drying equipment, drying at the set temperature of 70 ℃ until the dry extract is crushed by a crushing device to obtain the pueraria flower extract.
2. The preparation of the kudzuvine flower effervescent tablet comprises the following steps:
weighing 0.25 part of pueraria flower extract, 1.2 parts of citric acid, 1.2 parts of sodium bicarbonate, 0.9 part of low-substituted hydroxypropyl cellulose, 0.12 part of sodium carboxymethylcellulose, 3 parts of lactose and 0.4 part of sodium benzoate respectively according to the following parts by mass, sieving with a 100-mesh sieve, uniformly mixing, putting into a tablet press after mixing, and tabletting to obtain the pueraria flower effervescent tablet.
Example 4
1. Preparing a pueraria flower extract:
selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min; placing flos Puerariae Lobatae and its soaking solution in decocting equipment, adding 8 times of water, decocting for 2 times, each time for 2 hr, and soaking at 70 deg.C to obtain soaking solution; filtering the obtained warm extract, placing the filtrate in an evaporation system, setting the temperature at 65 ℃ and the rotating speed at 60rad/min, evaporating to obtain a thick extract, and taking out; and (3) placing the obtained thick extract in drying equipment, drying at the set temperature of 70 ℃ until the dry extract is crushed by a crushing device to obtain the pueraria flower extract.
2. The preparation of the kudzuvine flower effervescent tablet comprises the following steps:
weighing 0.25 part of pueraria flower extract, 1.8 parts of tartaric acid, 1.8 parts of sodium carbonate, 0.8 part of microcrystalline cellulose, 0.12 part of polyvinyl alcohol, 3 parts of cane sugar and 0.4 part of sodium chloride according to the following parts by mass, sieving with a 100-mesh sieve, mixing uniformly, placing in a tabletting machine after mixing, and tabletting to obtain the pueraria flower effervescent tablet.
Example 5
1. Preparing a pueraria flower extract:
selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min; placing flos Puerariae Lobatae and its soaking solution in decocting equipment, adding 12 times of water, decocting for 3 times, each time for 2 hr, and soaking at 100 deg.C to obtain soaking solution; filtering the obtained warm extract, placing the filtrate in an evaporation system, setting the temperature at 70 ℃ and the rotation speed at 70rad/min, evaporating to obtain a thick extract, and taking out; and (3) placing the obtained thick extract in drying equipment, drying at the set temperature of 70 ℃ until the dry extract is crushed by a crushing device to obtain the pueraria flower extract.
2. The preparation of the kudzuvine flower effervescent tablet comprises the following steps:
0.4 part of pueraria flower extract, 2.16 parts of tartaric acid, 2.16 parts of sodium bicarbonate, 2.08 parts of sodium bicarbonate, 300.24 parts of povidone K, 4 parts of mannitol and 60000.4 parts of PEG are respectively weighed according to the following parts by mass, sieved by a 100-mesh sieve, mixed uniformly, placed in a tablet machine after mixing and tableted to prepare the pueraria flower effervescent tablet.
Disintegration test:
the following table shows the data obtained by disintegrating the effervescent tablets of pueraria lobata prepared according to examples 1 to 5 in 250ml beakers containing 200ml of distilled water at 25 c, respectively.
TABLE-determination of disintegration time of effervescent tablet of flos Puerariae Lobatae
| Example No. 2 | Disintegration time/s |
| 1 | 289 |
| 2 | 235 |
| 3 | 177 |
| 4 | 265 |
| 5 | 198 |
As can be seen from the table I, the disintegration time of the pueraria flower effervescent tablets of examples 1 to 5 is not more than 5 minutes, and the disintegration time of example 3 is the shortest, and example 3 is the best example based on the disintegration time of the prepared pueraria flower effervescent tablets.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.
Claims (6)
1. The pueraria flower effervescent tablet is characterized by comprising the following components in parts by mass: 0.05 to 0.4 portion of pueraria flower extract, 1 to 2.16 portions of acid source, 1 to 2.16 portions of alkali source, 0.4 to 2.08 portions of auxiliary disintegrating agent, 0.04 to 0.24 portion of adhesive, 2 to 4 portions of filling agent and 0.4 portion of lubricant.
2. The pueraria flower effervescent tablet of claim 1, wherein the preparation method of the pueraria flower effervescent tablet comprises the following steps:
s1, soaking: selecting dried flos Puerariae Lobatae with good quality, and soaking in water for 30 min;
s2, warm dipping: putting the pueraria lobata flower obtained in the step S1 and the soaking liquid thereof into a decocting device, putting 8-12 times of water, and stewing for 1-3 times, wherein the time is 1-2 hours each time, and the warm soaking temperature is 60-100 ℃ to obtain a warm soaking liquid;
s3, filtering and concentrating: filtering the warm immersion liquid obtained in the step S2, putting the filtrate into an evaporation system, setting the temperature at 60-70 ℃ and the rotating speed at 40-70 rad/min, evaporating to form a thick extract, and taking out;
s4, drying and crushing: placing the thick extract obtained in the step S3 in drying equipment, and drying at the set temperature of 65-70 ℃ until the dry extract is crushed by a crushing device to obtain a pueraria flower extract for later use;
s5, weighing: weighing 0.05-0.4 part of pueraria flower extract, 1-2.16 parts of acid source, 1-2.16 parts of alkali source, 0.4-2.08 parts of auxiliary disintegrating agent, 0.04-0.24 part of adhesive, 2-4 parts of filler and 0.4 part of lubricant according to the following parts by mass;
s6, pretreatment of raw materials: sieving the flos Puerariae Lobatae extract obtained in step S5, acid source, alkali source, auxiliary disintegrating agent, binder, filler, and lubricant with 100 mesh sieve;
s7, tabletting: and (4) uniformly mixing the pueraria flower extract obtained in the step (S6), a disintegrating agent, an adhesive, a filling agent and a lubricating agent, and then putting the mixture into a tablet machine for tabletting to obtain the pueraria flower effervescent tablet.
3. The effervescent tablet of flos puerariae lobatae of claim 1, wherein the acid source is one of glutaric acid, citric acid, and tartaric acid; the alkali source is one of sodium bicarbonate, sodium percarbonate and sodium carbonate; the auxiliary disintegrating agent is one of low-substituted hydroxypropyl cellulose and microcrystalline cellulose.
4. The effervescent tablet of flos puerariae lobatae of claim 1, wherein the binder is one of polyvinyl alcohol, povidone K30 and sodium carboxymethylcellulose.
5. The effervescent tablet of pueraria lobata of claim 1, wherein the bulking agent is one of mannitol, lactose, sucrose and glucose.
6. The effervescent tablet of flos puerariae lobatae of claim 1, wherein the lubricant is one of PEG4000, PEG6000, sodium benzoate and sodium chloride.
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Non-Patent Citations (1)
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| 李京九等: "葛花含片的工艺及其性能", 《食品工业》 * |
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