CN106666753A - Biological activity high-calcium tablet - Google Patents
Biological activity high-calcium tablet Download PDFInfo
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- CN106666753A CN106666753A CN201510755275.0A CN201510755275A CN106666753A CN 106666753 A CN106666753 A CN 106666753A CN 201510755275 A CN201510755275 A CN 201510755275A CN 106666753 A CN106666753 A CN 106666753A
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- Prior art keywords
- carboxyrnethyl starch
- tablet
- calcium
- starch sodium
- biologically active
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- 239000011575 calcium Substances 0.000 title claims abstract description 45
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 45
- 230000004071 biological effect Effects 0.000 title abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 41
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 19
- 102000008186 Collagen Human genes 0.000 claims abstract description 19
- 108010035532 Collagen Proteins 0.000 claims abstract description 19
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 19
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 17
- 229920002472 Starch Polymers 0.000 claims description 63
- 235000015424 sodium Nutrition 0.000 claims description 63
- 239000008107 starch Substances 0.000 claims description 63
- 235000019698 starch Nutrition 0.000 claims description 63
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 43
- 229910052708 sodium Inorganic materials 0.000 claims description 43
- 239000011734 sodium Substances 0.000 claims description 43
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 25
- 239000002002 slurry Substances 0.000 claims description 19
- 239000011248 coating agent Substances 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 14
- 235000019359 magnesium stearate Nutrition 0.000 claims description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 14
- 238000000576 coating method Methods 0.000 claims description 12
- 238000005469 granulation Methods 0.000 claims description 12
- 230000003179 granulation Effects 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- 235000020985 whole grains Nutrition 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000007888 film coating Substances 0.000 claims description 10
- 238000009501 film coating Methods 0.000 claims description 10
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000001087 glyceryl triacetate Substances 0.000 claims description 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 235000010215 titanium dioxide Nutrition 0.000 claims description 2
- 229960002622 triacetin Drugs 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 9
- 208000001132 Osteoporosis Diseases 0.000 abstract description 8
- 210000000988 bone and bone Anatomy 0.000 abstract description 7
- 210000002449 bone cell Anatomy 0.000 abstract description 5
- 230000010261 cell growth Effects 0.000 abstract description 5
- 230000037182 bone density Effects 0.000 abstract description 4
- 229920001436 collagen Polymers 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000000295 complement effect Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000004224 protection Effects 0.000 abstract description 2
- 229940069978 calcium supplement Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 230000032683 aging Effects 0.000 description 3
- 206010065687 Bone loss Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000005802 health problem Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000001009 osteoporotic effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a biological activity high-calcium tablet and belongs to the field of health products. The biological activity high-calcium tablet comprises: coral calcium, collagen powder, chondroitin sulfate and auxiliary materials. The biological activity high-calcium tablet utilizes coral calcium as a calcium supplement source, collagen powder to promote absorption of calcium and bone cell growth and chondroitin sulfate to promote bone cell growth, inflammatory resistance and protection of bones and joints, and the above materials are complementary with other auxiliary materials. The product has a scientific formula, is reasonable and safe, is suitable for prevention, improvement and treatment on osteoporosis diseases of middle-aged and older people and can increase bone density of middle-aged and older people.
Description
Technical field
The present invention relates to a kind of health food, more particularly to a kind of biologically active high calcium tablet and preparation method thereof.
Calcium is one of most common element in human body, there are about 1200 grams, the most element of people's in-vivo content, it is also one of the element for being easiest to lack, it is referred to as " armored concrete in life ", the content of calcium accounts for the 1.5-2% of TBW in human body, wherein bone and tooth accounts for 99%.Body fluid and soft tissue account for 1%.For vital effect is played in body metabolism, cell function, nervous system running, protein hormones synthesis etc..Calcium tablet species is more, such as：Inorganic calcium tablet, organic calcium tablet, atom calcium tablet, milk calcium etc.；Human body is different to the assimilation effect of different types of calcium tablet, it can be seen that the calcium tablet of exploitation human body high-absorbility is highly desirable to.
Osteoporosis is a kind of one of common bone disease of clinic.Occurring in person in middle and old age osteoporosis, the serious harm health of the elderly more.With the aggravation of Future population aging, the osteoporosis of the elderly and its a series of health problems that may be brought particularly merit attention.
The reason for causing osteoporosis is a lot, and the shortage of calcium is by one of acknowledged factor.Sufficient calcium intake can slow down the loss of bone amount, improve bone mineralising.Great majority research shows, after the bone loss relevant with age or menopause, increasing the supplement of calcium can only play reduction bone loss, maintain the effect of bone amount level, increase that can not be effective and lasting, reduce osteoporotic incidence, needs store enough calcareous by rational nutrition.
Therefore, calcareous reasonable, effective supplement is closely related with osteoporotic prevention and treatment.China has been enter into aging society, and various the elder's health problems that calcium deficiency causes have caused the concern of society.
The content of the invention
Present invention aim at provide it is a kind of aim at the elderly design, with supplement calcium, promote bone cell growth, anti-inflammatory and protection Bones and joints; the osteoporosis of the elderly can be effectively improved, reaching increases biologically active high calcium tablet of health-care efficacy of middle-aged and old bone densities and preparation method thereof.
To solve the above problems, the technical solution adopted in the present invention is：A kind of biologically active high calcium tablet, is mainly prepared from by the raw material of following percentage by weight：Coral calcium 50%-60%, collagen protein powder 15%-20%, chondroitin sulfate 3%-15%.
The biologically active high calcium tablet is also including the auxiliary material of following percentage by weight：Microcrystalline cellulose 6-15%, carboxyrnethyl starch sodium 5-20%, magnesium stearate 0.5-2%
And film coating agent 1.0-2.5%.
The film coating agent is：Hydroxypropyl methylcellulose, titanium dioxide, talcum powder, polyvinyl alcohol, glyceryl triacetate.
The preparation method of biologically active high calcium tablet of the present invention, including step in detail below：
（1）The raw material of following percentage by weight is weighed by formula：Coral calcium 50%-60%, collagen protein powder 15%-20%, chondroitin sulfate 3%-15% and auxiliary material：Microcrystalline cellulose 6-15%, carboxyrnethyl starch sodium 5-20%, magnesium stearate 0.5-2%
And film coating agent 1.0-2.5%；
（2）The preparation of 6% carboxyrnethyl starch sodium slurry：By step（1）The carboxyrnethyl starch sodium 5-20% for weighing is divided into 11-19 parts, takes 1 part of carboxyrnethyl starch sodium purified water therein and is configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
（3）Mixing, granulation：By the 5-9 part carboxyrnethyl starch sodiums in coral calcium 50%-60%, chondroitin sulfate 3%-15%, microcrystalline cellulose 6-15% and 11-19 part carboxyrnethyl starch sodium; in adding efficient wet mixer-granulator; mixing 8-15min; the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6% is added, wet granular is obtained；
（4）Dry, whole grain：By prepared wet granular under the conditions of 55～65 DEG C, after dry 20～30min, 16 mesh sieve whole grains, prepared whole good particle are crossed；
（5）Total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, add remaining 5-9 parts carboxyrnethyl starch sodium, collagen protein powder 15%-20% and magnesium stearate 0.5-2% in 11-19 part carboxyrnethyl starch sodiums, after mixing 20-30min, Jing fully automatic high-speed tabletting machines are obtained tablet；
（6）Coating, packaging：Dissolving films coating agent 1.0-2.5%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
The present invention is relative to the beneficial effect of prior art：
（1）It, using coral calcium as the calcareous source of needed by human body is supplied, is the monarch in compatibility that biologically active high calcium tablet of the present invention is；It is 100% pure natural components, coral calcium contains very the calcareous of high concentration, main mine material and trace mineral, these mineral matters are all with the presence of ion kenel, need not digest through hydrochloric acid in gastric juice again, just can be absorbed by the body immediately, in being directly entered blood, absorptivity may be up to more than 90%, human nutrition balance metabolism is best suited for, is alkalescent healthy food；The trace mineral enriched in coral is the key factor of its huge efficiency.Because it is easy to absorb and will not produce the effect of constipation.
（2）Collagen is a kind of celloglobulin, there is the function of promoting calcium uptake and bone cell growth simultaneously, the enough collagens of intake can to a certain extent ensure normal calcareous requirement, therefore, promote the absorption of calcium in formula with collagen protein powder, supplement the bone amount loss that mid-aged population occurs with aging；Chondroitin sulfate is a kind of acid mucopolysaccharide that preparation is extracted from animal tissue, chondroitin sulfate of arranging in pairs or groups in formula so that the biologically active high calcium tablet of the present invention can promote bone cell growth, and with anti-inflammatory and protect osteoarticular effect；Simultaneously product of the present invention is aided with microcrystalline cellulose, carboxyrnethyl starch sodium, magnesium stearate, film coating agent as auxiliary material, complement each other with above-mentioned primary raw material, so as to be effectively improved osteoporosis, reaching increases the health-care efficacy of bone density, formula design science, reasonable, safety；
（3）It is with strong points：Biologically active high calcium tablet of the present invention aims at the elderly and designs, with strong points, can be effectively improved middle-aged and old osteoporosises, reach the health care for increasing middle-aged and old bone densities；
（4）Material species in biologically active high calcium slice prescription Central Plains of the present invention is more, consumption is big, therefore when product forms are considered, select using with matter-loading amount it is big, dose can be reduced the characteristics of tablet as formulation, simultaneously, in order to be further ensured that tablet quality and be easy to take, improve the outward appearance of tablet, be easy to identification, it is final to determine that product of the present invention is coated tablet, with taking, preserve, outgoing carrying all very easily advantages；
（5) preparation process of biologically active high calcium tablet of the present invention is significant composition to control the quality of product with calcium, protein, chondroitin sulfate, and detection method is ripe, and product quality is guaranteed；The granulating process of biologically active high calcium tablet of the present invention is to add disintegrant by interior addition, strengthens the disintegration effect of product of the present invention；The preparation technology of product of the present invention is reasonable, method is simple, and production efficiency is high.
Specific embodiment
The present invention is described in further details below by embodiment, these embodiments are only used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1 prepares a kind of biologically active high calcium tablet using following raw materials according, ratio of adjuvant and preparation method.
1st, raw material and auxiliary material are weighed by formula（By weight percentage）：Raw material：Coral calcium 50%, collagen protein powder 15%, chondroitin sulfate 8%；Auxiliary material：Microcrystalline cellulose 9%, carboxyrnethyl starch sodium 15%, magnesium stearate 1% and film coating agent 2%.
2nd, preparation method and step：
1) preparation of 6% carboxyrnethyl starch sodium slurry：The carboxyrnethyl starch sodium for weighing 15% is divided into 11 parts, takes 1 part of carboxyrnethyl starch sodium purified water therein and is configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
2) mixing, granulation：By 5 parts of carboxyrnethyl starch sodiums in coral calcium 50%, chondroitin sulfate 8%, microcrystalline cellulose 9% and 11 parts of carboxyrnethyl starch sodiums; in adding efficient wet mixer-granulator; mixing 10min, adds the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6%, and wet granular is obtained；
3) dry, whole grain：By prepared wet granular under the conditions of 60 DEG C, after being dried 30min, 16 mesh sieve whole grains are crossed, whole good particle is obtained；
4) total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, remaining 5 parts of carboxyrnethyl starch sodiums, collagen protein powder 15% and magnesium stearate 1% in 11 parts of carboxyrnethyl starch sodiums is added, after mixing 20min, Jing fully automatic high-speed tabletting machines are obtained tablet；
5) coating, packaging：Dissolving films coating agent 2%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
Embodiment 2 prepares a kind of biologically active high calcium tablet using following raw materials according, ratio of adjuvant and preparation method.
1st, raw material and auxiliary material are weighed by formula（By weight percentage）：Raw material：Coral calcium 50%, collagen protein powder 20%, chondroitin sulfate 6%；Auxiliary material：Microcrystalline cellulose 10%, carboxyrnethyl starch sodium 10.5%, magnesium stearate 1.0% and film coating agent 2.5%.
2nd, preparation method and step：
1) preparation of 6% carboxyrnethyl starch sodium slurry：The carboxyrnethyl starch sodium for weighing 10.5% is divided into 13 parts, takes 1 part of carboxyrnethyl starch sodium purified water therein and is configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
2) mixing, granulation：By 6 parts of carboxyrnethyl starch sodiums in coral calcium 50%, chondroitin sulfate 6%, microcrystalline cellulose 10% and 13 parts of carboxyrnethyl starch sodiums; in adding efficient wet mixer-granulator; mixing 15min, adds the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6%, and wet granular is obtained；
3) dry, whole grain：By prepared wet granular under the conditions of 65 DEG C, after being dried 20min, 16 mesh sieve whole grains are crossed, whole good particle is obtained；
4) total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, remaining 6 parts of carboxyrnethyl starch sodiums, collagen protein powder 20% and magnesium stearate 1.0% in 13 parts of carboxyrnethyl starch sodiums is added, after mixing 30min, Jing fully automatic high-speed tabletting machines are obtained tablet；
5) coating, packaging：Dissolving films coating agent 2.5%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
Embodiment 3 prepares a kind of biologically active high calcium tablet using following raw materials according, ratio of adjuvant and preparation method.
1st, raw material and auxiliary material are weighed by formula（By weight percentage）：Raw material：Coral calcium 55%, collagen protein powder 15%, chondroitin sulfate 6%；Auxiliary material：Microcrystalline cellulose 8%, carboxyrnethyl starch sodium 13.5%, magnesium stearate 0.8% and film coating agent 1.7%.
2nd, preparation method and step：
1) raw material and auxiliary material are weighed by formula；
2) preparation of 6% carboxyrnethyl starch sodium slurry：The carboxyrnethyl starch sodium for weighing 13.5% is divided into 15 parts, takes 1 part of carboxyrnethyl starch sodium purified water therein and is configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
3) mixing, granulation：By 7 parts of carboxyrnethyl starch sodiums in coral calcium 55%, chondroitin sulfate 6%, microcrystalline cellulose 8% and 15 parts of carboxyrnethyl starch sodiums; in adding efficient wet mixer-granulator; mixing 10min, adds the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6%, and wet granular is obtained；
4) dry, whole grain：By prepared wet granular under the conditions of 60 DEG C, after being dried 25min, 16 mesh sieve whole grains are crossed, whole good particle is obtained；
5) total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, remaining 7 parts of carboxyrnethyl starch sodiums, collagen protein powder 15% and magnesium stearate 0.8% in 15 parts of carboxyrnethyl starch sodiums is added, after mixing 30min, Jing fully automatic high-speed tabletting machines are obtained tablet；
6) coating, packaging：Dissolving films coating agent 1.7%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
Embodiment 4 prepares a kind of biologically active high calcium tablet using following raw materials according, ratio of adjuvant and preparation method.
1st, raw material and auxiliary material are weighed by formula（By weight percentage）：Raw material：Coral calcium 60%, collagen protein powder 15%, chondroitin sulfate 4%；Auxiliary material：Microcrystalline cellulose 7%, carboxyrnethyl starch sodium 11%, magnesium stearate 1.5% and film coating agent 1.5%.
2nd, preparation method and step：
1) preparation of 6% carboxyrnethyl starch sodium slurry：The carboxyrnethyl starch sodium for weighing 11% is divided into 17 parts, takes 1 part of carboxyrnethyl starch sodium purified water therein and is configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
2) mixing, granulation：By 8 parts of carboxyrnethyl starch sodiums in carboxyrnethyl starch sodium slurry, coral calcium 60%, chondroitin sulfate 4%, microcrystalline cellulose 7% and 17 parts of carboxyrnethyl starch sodiums that the mass fraction for preparing is 6%; in adding efficient wet mixer-granulator; mixing 15min; the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6% is added, wet granular is obtained；
3) dry, whole grain：By prepared wet granular under the conditions of 55 DEG C, after being dried 25min, 16 mesh sieve whole grains are crossed, whole good particle is obtained；
4) total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, remaining 8 parts of carboxyrnethyl starch sodiums, collagen protein powder 15% and magnesium stearate 1.5% in 17 parts of carboxyrnethyl starch sodiums is added, after mixing 25min, Jing fully automatic high-speed tabletting machines are obtained tablet；
5) coating, packaging：Dissolving films coating agent 1.5%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
Claims (2)
1. a kind of biologically active high calcium tablet, it is characterised in that：Mainly it is prepared from by the raw material of following percentage by weight：Coral calcium 50-60%, collagen protein powder 15-20%, chondroitin sulfate 3-10%；
The preparation method of the biologically active high calcium tablet, comprises the following steps that：
（1）The raw material of following percentage by weight is weighed by formula：Coral calcium 50-60%, collagen protein powder 15-20%, chondroitin sulfate 3-10% and auxiliary material：Microcrystalline cellulose 6-15%, carboxyrnethyl starch sodium 5-20%, magnesium stearate 0.5-2% and film coating agent 1.0-2.5%；
（2）The preparation of 6% carboxyrnethyl starch sodium slurry：By step（1）The carboxyrnethyl starch sodium 5-20% for weighing is divided into 11-19
Part, take 1 part of carboxyrnethyl starch sodium purified water therein and be configured to the carboxyrnethyl starch sodium slurry that mass fraction is 6%；
（3）Mixing, granulation：By coral calcium 50-60%, chondroitin sulfate 4-10%, microcrystalline cellulose 6-15% and 11-19
5-9 part carboxyrnethyl starch sodiums in part carboxyrnethyl starch sodium, in adding efficient wet mixer-granulator, mix 8-15min, add the carboxyrnethyl starch sodium slurry granulation that the mass fraction for preparing is 6%, prepared wet granular；
（4）Dry, whole grain：By prepared wet granular under the conditions of 55-65 DEG C, after dry 20～30min, 16 mesh sieve whole grains, prepared whole good particle are crossed；
（5）Total mixed, compressing tablet：Whole good particle is placed in three-dimensional motion mixer, remaining 5-9 in 11-19 part carboxyrnethyl starch sodiums is added
Part carboxyrnethyl starch sodium, collagen protein powder 15-20% and magnesium stearate 0.5-2%, after mixing 20-30min, Jing fully automatic high-speed tabletting machines are obtained tablet；
（6）Coating, packaging：Dissolving films coating agent 1.0-2.5%, is coated in prepared tablet using seed-coating machine, that is, biologically active high calcium tablet is obtained.
2. the biologically active high calcium tablet according to claim 1, it is characterised in that：The film coating agent is：Hydroxypropyl methylcellulose, titanium dioxide, talcum powder, polyvinyl alcohol, glyceryl triacetate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510755275.0A CN106666753A (en) | 2015-11-09 | 2015-11-09 | Biological activity high-calcium tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510755275.0A CN106666753A (en) | 2015-11-09 | 2015-11-09 | Biological activity high-calcium tablet |
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| Publication Number | Publication Date |
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| CN106666753A true CN106666753A (en) | 2017-05-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
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- 2015-11-09 CN CN201510755275.0A patent/CN106666753A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
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Application publication date: 20170517 |