CN112754047A - Preparation method of hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsules - Google Patents
Preparation method of hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsules Download PDFInfo
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- CN112754047A CN112754047A CN202011074946.4A CN202011074946A CN112754047A CN 112754047 A CN112754047 A CN 112754047A CN 202011074946 A CN202011074946 A CN 202011074946A CN 112754047 A CN112754047 A CN 112754047A
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- 239000002775 capsule Substances 0.000 title claims abstract description 92
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 title claims abstract description 32
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 title claims abstract description 32
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 title claims abstract description 32
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 150000004676 glycans Chemical class 0.000 title claims abstract description 23
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 23
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 241001474374 Blennius Species 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 55
- 238000003756 stirring Methods 0.000 claims abstract description 54
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- 238000004321 preservation Methods 0.000 claims abstract description 11
- 239000008213 purified water Substances 0.000 claims abstract description 10
- 238000010923 batch production Methods 0.000 claims abstract description 8
- 239000003292 glue Substances 0.000 claims description 174
- 238000004519 manufacturing process Methods 0.000 claims description 22
- 239000011229 interlayer Substances 0.000 claims description 15
- 238000007598 dipping method Methods 0.000 claims description 14
- 238000007689 inspection Methods 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 12
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- 108010010803 Gelatin Proteins 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000679 carrageenan Substances 0.000 claims description 6
- 235000010418 carrageenan Nutrition 0.000 claims description 6
- 229920001525 carrageenan Polymers 0.000 claims description 6
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- 239000008273 gelatin Substances 0.000 claims description 6
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- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 6
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- 238000000034 method Methods 0.000 claims 6
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- 241000196324 Embryophyta Species 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 229960003943 hypromellose Drugs 0.000 description 7
- 239000001341 hydroxy propyl starch Substances 0.000 description 6
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 6
- 239000004373 Pullulan Substances 0.000 description 5
- 229920001218 Pullulan Polymers 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
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- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 238000000465 moulding Methods 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 1
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- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
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- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
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- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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Abstract
The invention discloses a preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule, which comprises the following steps: step S1: sol: adding water: adding a proper amount of purified water into the sol tank according to the requirement of batch production instructions; feeding, heating, feeding and stirring: feeding tailings: according to the requirement of batch production instructions, adding metered purified water into a sol tank, starting a stirring motor, slowly adding weighed tailings into the sol tank, and starting to heat after stirring is stopped; and (3) heating: setting the temperature controller at 95 deg.c, opening the steam main valve, setting the steam temperature and opening the steam electric control valve. The invention reasonably measures the proportion of the raw materials, the auxiliary materials and the purified water, and controls the temperature control points and time nodes of each link during sol making and the heat preservation time, so that the capsule has proper viscosity, quick capsule forming, consistent uniformity and no peculiar smell in the preparation process.
Description
Technical Field
The invention relates to the technical field of hollow capsule production, in particular to a preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule.
Background
With the increase of capsule varieties, the diversity of the contents of the capsules is gradually recognized, and the gelatin hollow capsules have the compatibility problem with some contents with special properties. For example, a content containing an aldehyde group or reacting under certain conditions to form an aldehyde group may cause a crosslinking reaction of gelatin; the content with strong reducibility can generate Maillard reaction with gelatin; the content with strong hygroscopicity can dehydrate the shell of the gelatin capsule and lose the original toughness. The stability problems of the above-mentioned gelatin hollow capsules have led to increased interest in the development of new capsule materials.
Therefore, with the research and development and industrialization of plant-derived hollow capsules (pullulan hollow capsules, hypromellose hollow capsules and hydroxypropyl starch hollow capsules) in China, the plant-derived hollow capsules have the characteristics of unique safety, stability, antibacterial property, relevance, no obstacle, superiority, value increasing property, environmental protection, inertia and the like, make up the defects of animal-derived gelatin hollow capsules, solve the special requirement of capsule compatibility on hollow capsules and change the product structure of the medicinal hollow capsules to a certain extent. However, the prescription of the plant source capsule is complex, some gelling agents need to be added, and the production process is also complex. Compared with the plant source capsule, the animal source gelatin capsule has the advantages of absolute glossiness and fluency of the formed appearance, and can be absorbed by human body due to the fact that the main raw material of the gelatin capsule is the plateau protein gelatin besides the function of the carrier.
The pullulan hollow capsule in the plant capsule is a plant hollow capsule produced by taking pullulan (mainly prepared from saccharides extracted from bean sprouts and malt) as a main raw material. The pullulan polysaccharide is easy to dissolve in water, safe, non-toxic and edible, low in calorific value, acid and alkali resistant, good in plasticity, good in film forming property and good in film gas barrier property. Since it is a water-soluble polysaccharide, it is not digested by in vivo enzymes and can be discharged from the body. Is mainly applied to the fields of diabetes, obesity patients, low-calorie foods, medicines, skin care products and the like. Can promote the growth of bifidobacteria in intestinal tract, maintain flora balance, and relieve constipation. Completely avoids the trouble of some infectious disease sources possibly possessed by the animal-derived hollow capsule, and is an ideal upgraded substitute product of the traditional animal-derived capsule. However, the glossiness and fluency of the appearance of the pulullan empty capsule after molding are only inferior to those of a gelatin capsule, but the production cost of the raw materials is the highest in the plant source capsules.
The hydroxypropyl starch capsule has the main raw material of pregelatinized hydroxypropyl starch (the main raw material is cassava starch), the glossiness and the fluency of the formed hydroxypropyl starch capsule are only similar to those of a pullulan capsule, but the hydroxypropyl starch capsule has the characteristics of wide raw material source, lowest production cost of the raw material and shortest disintegration time, and the formed hydroxypropyl starch capsule has the characteristics of being absorbed by a human body, and is easy to become brittle and shorter in quality guarantee period after being formed due to the performance of the raw material.
The hydroxypropyl methylcellulose capsule is prepared by treating cotton linter or wood pulp fiber with caustic soda, reacting with chloromethane and propylene oxide, refining, and pulverizing. The hypromellose capsule is a product with a natural concept, the material and the production process of the hypromellose capsule are accepted by kosher, islamic and vegetarians, the hypromellose capsule can meet the requirements of people with various religious and vegetarian dietary habits, the acceptance is high, but the glossiness and the fluency after molding are inferior to those of the various capsules, and the hypromellose capsule is only used as a carrier and cannot be absorbed by human bodies. The special inertia is not influenced by the temperature and humidity of the environment, the risk of influencing the quality in transportation and storage is avoided, and the quality guarantee period is longest; because the plant fiber is adopted, the prepared capsule is not easy to become crisp, so the preparation method of the hollow capsule of hydroxypropyl methylcellulose and algal polysaccharide is provided.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule.
The invention provides a preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule, which comprises the following steps:
step S1: sol:
adding water: adding a proper amount of purified water into the sol tank according to the requirement of batch production instructions;
feeding, heating, feeding and stirring:
feeding tailings: according to the requirement of batch production instructions, adding metered purified water into a sol tank, starting a stirring motor, slowly adding weighed tailings into the sol tank, and starting to heat after stirring is stopped;
and (3) heating: setting the temperature controller at 95 ℃, starting a steam main valve, setting steam to be heated, and starting a steam electric control valve; steam enters through an upper interlayer pipeline of the sol tank, flows out through a lower interlayer pipeline, and is changed into condensed water through an output valve to be discharged;
feeding raw materials and auxiliary materials and stirring: after the temperature of the gel liquid in the gel dissolving tank is heated to 95 ℃, slowly adding the weighed hydroxypropyl methylcellulose moderate carrageenan into the gel dissolving tank, stirring for 20 minutes until the weighed hydroxypropyl methylcellulose moderate carrageenan is uniform, slowly adding the weighed auxiliary materials into the gel dissolving tank according to the requirement of a production order list, and stirring uniformly;
stirring at high temperature, vacuumizing, and dissolving: after all raw materials, auxiliary materials and tailings are fed according to the production instruction list, heating to 95 ℃ for sol, opening a vacuum pump valve switch, and vacuumizing while stirring to remove bubbles: when the liquid level rises to about 20cm away from the vacuum air suction port, half opening the exhaust valve to lower the liquid level; repeating the action for 4-5 times until the liquid level does not rise any more, closing the vacuum valve, and stopping vacuumizing; keeping the temperature of the glue solution in the glue dissolving tank at 95 ℃, stirring at high temperature for 60 minutes, and then cooling;
cooling and stirring: setting a sol filling temperature controller to be 50 ℃, setting a hot water tank temperature controller to cool hot water at 35 ℃, and when an electric control hot water valve is opened, circulating water for cooling flows from a lower interlayer pipeline of the glue pot to an upper interlayer pipeline of the glue pot through a hot water tank and then returns to the hot water tank to realize heat dissipation and cooling of the circulating water; adjusting the flow rate to slowly reduce the temperature of the glue solution to a specified temperature, and stirring while reducing the temperature to ensure that the glue solution is uniform;
stirring at constant temperature: when the temperature of the glue solution is reduced to 50 ℃, continuously stirring for 60 minutes at constant temperature to ensure that the glue solution is uniformly dispersed;
sixthly, viscosity measurement-correction-glue release: after stirring for 60 minutes at constant temperature, turning off the stirring motor, and stopping stirring; taking a proper amount of glue solution by using a 500ml beaker, placing the glue solution in a 50 ℃ constant temperature water bath, accurately measuring the viscosity value of the glue solution by using an online viscometer, controlling the time to be 10 minutes, wherein the viscosity value requirement meets 2300-2400cps, and if the viscosity value of the glue solution is not in a specified range, adding a certain proportion of 60 ℃ hot water and stirring for 30 minutes to perform viscosity correction until the viscosity value meets the requirement, and filling the original record; when the viscosity value correction of the glue solution meets the requirement, connecting a glue placing pipe, placing the glue placing pipe into a heat-insulated glue barrel, ensuring that the water level and the water temperature of an interlayer of the heat-insulated barrel of the glue barrel meet the requirement, and starting to place the glue by opening a glue placing valve at the bottom of a glue dissolving tank; after the glue is put, the glue barrel is placed in a heat insulation area, a power supply and a sensor are plugged, and a body or cap glue solution state marking sheet is filled and written respectively;
keeping the temperature: respectively setting the body heat preservation temperature of 53 ℃ and the cap heat preservation temperature of 51 ℃ according to the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line, and detecting whether the actual temperature of the glue solution of the heat preservation barrel meets the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line every 2 hours by using a thermometer to ensure that the glue solution is placed for 18-24 hours for standby application;
step S2: preparing a capsule:
preparing: adjusting the indoor temperature and humidity of the host;
operation II:
when the temperature of the glue dipping tank reaches the set temperature, glue is released, and the actual temperature of the glue solution of the glue barrel is 1.0 ℃ higher than that of the glue solution of the glue tank; then, glue discharging is started, the temperature of the glue tank is measured after the glue bundle is discharged for 30 minutes, and the actual temperature of the glue solution of the glue tank is adjusted according to the viscosity of the glue solution;
after glue dipping is started, the temperature of the glue groove is adjusted according to the wall thickness, the position of the glue groove is adjusted according to the top thickness, the wall thickness and the top thickness meet the quality standard, and the wall thickness is adjusted in sequence of firstly adjusting the wall thickness and then adjusting the top thickness;
adjusting attention items:
the actual temperature of the glue solution in the glue tank, the environmental temperature of the front chamber and the rear chamber, and the actual temperature of the glue solution in the glue barrel are 1 ℃ higher than the actual temperature of the glue solution in the glue tank;
quality control points:
the inspectors are capsule manufacturing personnel and QA in class, and the wall thickness, the top thickness, the light inspection, the cut, the length, the grain weight, the size and the moisture detection are carried out on the capsule.
Preferably, in step S1, the gelling agent is low acyl gellan gum.
Preferably, in step S1, the titanium dioxide mother liquor is used as the auxiliary material when the hollow capsule is an opaque capsule, and the pigment liquor is used as the auxiliary material when the hollow capsule is a colored capsule.
Preferably, in step S1, the switching pressure of the vacuum pump valve is 0.060 to 0.075 MPa.
Preferably, in step S2, the main indoor temperature/humidity adjustment criterion is the front room temperature: 22.5 ± 0.5 ℃, relative humidity: 50-65%; rear chamber temperature: 31.5 ± 0.5 ℃, relative humidity: 30 to 45 percent.
Preferably, in step S2, before the glue dipping is started, the on-line viscometer is started to measure the viscosity, the viscosity of the cap glue solution is controlled at 2200 centipoises, the viscosity of the body glue solution is controlled at 2300 centipoises, and the glue dipping is started after the viscosity is stabilized for 5-15 minutes.
Preferably, in step S2, the relative viscosity of the dipping tank glue solution is: 2200-2400cps, checking the circulating water temperature of the glue groove every 2 hours, controlling the temperature of the cap glue groove between 51 and 53 ℃, controlling the temperature of the body glue groove between 50 and 52 ℃, and controlling the motor speed: 20-30 r/min.
Preferably, in step S2, the frequency of inspection is: the appearance quality detection method comprises the following steps of checking every 30 minutes: firstly, determining whether the wall thickness and the top thickness meet the standard, and then performing light inspection on a light inspection table, wherein the defects of uneven thickness, black spots, sand holes, bubbles, crisp chips and plum blossom heads are not more than 1 per thousand; the cutting requirement is free of gaps and glue threads; the length deviation of the cap A and the body B is less than or equal to +/-0.4 mm, and defective products are not more than 1 per thousand; the length and the length of the hollow capsule are matched, the capsule is split, and the defective product of a single capsule is not more than 1 per thousand.
The preparation method of the hydroxypropyl methylcellulose and algal polysaccharide hollow capsule has the beneficial effects that: the hypromellose capsule is a product which takes hypromellose as a main raw material and is added with algal polysaccharide in a certain proportion, the two raw materials have natural concepts, the materials and the production process are approved by kosher, Islam and vegetarians, the requirements of people with various religious and vegetarian dietary habits can be met, and the acceptance is high. The algal polysaccharide is prepared from natural algae in Chilean, Australia and other countries, and has the characteristics of high gel strength, high plasticity, good film forming performance, stable chemical performance and the like, and the polysaccharide component also has the effects of reducing blood fat, reducing blood sugar, resisting oxidation, resisting tumors and the like. Algal polysaccharide is an indispensable natural dietary fiber for human bodies, has unique nutrition, can combine organic matters, slow down the absorption of the human bodies to fatty sugar and bile salt, reduce cholesterol in serum and liver, inhibit the increase of total fat and total fatty acid concentration, reduce triglyceride and blood sugar in blood, improve the digestion and absorption of nutrient substances of the human bodies, and simultaneously can inhibit the accumulation and absorption of harmful elements such as radioactive strontium, cadmium, lead and the like in the human bodies in intestinal tracts. Has certain effect of preventing modern diseases such as hypertension, coronary heart disease, obesity, diabetes and the like and intestinal system diseases 7. The characteristics of safety and innocuity are confirmed by the food additive joint expert committee of the food and agriculture organization and the world health organization of the united nations, and the food and agriculture organization and the world health organization have the functions of improving the immunity of the human body, reducing the blood fat and the like;
the hydroxypropyl methylcellulose hollow capsule has unique inertia, is not influenced by the temperature and humidity of the environment, avoids the risk of influencing the quality in transportation and storage, and has the longest quality guarantee period; and because the capsule is made of plant fiber, the prepared capsule is not easy to become crisp. The capsule has the characteristics of natural non-pollution, long storage period (48 months, and 24 months for an animal gelatin capsule), less water content, difficult moisture absorption, difficult friability, stable disintegration time limit, beautiful appearance, high transparency, exquisite structure, various indexes, excellent safety and the like, and has low production cost and high profit return rate, thereby completely avoiding the trouble of some infectious disease sources possibly possessed by the animal hollow capsule, and being an ideal upgrade substitute for the traditional animal capsule;
the invention reasonably measures the proportion of the raw materials, the auxiliary materials and the purified water, and controls the temperature control points and time nodes of each link during sol making and the heat preservation time, so that the capsule has proper viscosity, quick capsule forming, consistent uniformity and no peculiar smell in the preparation process.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Examples
The invention provides a preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule, which comprises the following steps:
step S1: sol:
adding water: adding a proper amount of purified water into the sol tank according to the requirement of batch production instructions;
feeding, heating, feeding and stirring:
feeding tailings: according to the requirement of batch production instructions, adding metered purified water into a sol tank, starting a stirring motor, slowly adding weighed tailings into the sol tank, and starting to heat after stirring is stopped;
and (3) heating: setting the temperature controller at 95 ℃, starting a steam main valve, setting steam to be heated, and starting a steam electric control valve; steam enters through an upper interlayer pipeline of the sol tank, flows out through a lower interlayer pipeline, and is changed into condensed water through an output valve to be discharged;
feeding raw materials and auxiliary materials and stirring: after the temperature of the gel liquid in the gel dissolving tank is heated to 95 ℃, slowly adding the weighed hydroxypropyl methylcellulose moderate carrageenan into the gel dissolving tank, stirring for 20 minutes until the weighed hydroxypropyl methylcellulose moderate carrageenan is uniform, slowly adding the weighed auxiliary materials into the gel dissolving tank according to the requirement of a production order list, and stirring uniformly;
stirring at high temperature, vacuumizing, and dissolving: after all raw materials, auxiliary materials and tailings are fed according to the production instruction list, heating to 95 ℃ for sol, opening a vacuum pump valve switch, and vacuumizing while stirring to remove bubbles: when the liquid level rises to about 20cm away from the vacuum air suction port, half opening the exhaust valve to lower the liquid level; repeating the action for 4-5 times until the liquid level does not rise any more, closing the vacuum valve, and stopping vacuumizing; keeping the temperature of the glue solution in the glue dissolving tank at 95 ℃, stirring at high temperature for 60 minutes, and then cooling;
cooling and stirring: setting a sol filling temperature controller to be 50 ℃, setting a hot water tank temperature controller to cool hot water at 35 ℃, and when an electric control hot water valve is opened, circulating water for cooling flows from a lower interlayer pipeline of the glue pot to an upper interlayer pipeline of the glue pot through a hot water tank and then returns to the hot water tank to realize heat dissipation and cooling of the circulating water; adjusting the flow rate to slowly reduce the temperature of the glue solution to a specified temperature, and stirring while reducing the temperature to ensure that the glue solution is uniform;
stirring at constant temperature: when the temperature of the glue solution is reduced to 50 ℃, continuously stirring for 60 minutes at constant temperature to ensure that the glue solution is uniformly dispersed;
sixthly, viscosity measurement-correction-glue release: after stirring for 60 minutes at constant temperature, turning off the stirring motor, and stopping stirring; taking a proper amount of glue solution by using a 500ml beaker, placing the glue solution in a 50 ℃ constant temperature water bath, accurately measuring the viscosity value of the glue solution by using an online viscometer, controlling the time to be 10 minutes, wherein the viscosity value requirement meets 2300-2400cps, and if the viscosity value of the glue solution is not in a specified range, adding a certain proportion of 60 ℃ hot water and stirring for 30 minutes to perform viscosity correction until the viscosity value meets the requirement, and filling the original record; when the viscosity value correction of the glue solution meets the requirement, connecting a glue placing pipe, placing the glue placing pipe into a heat-insulated glue barrel, ensuring that the water level and the water temperature of an interlayer of the heat-insulated barrel of the glue barrel meet the requirement, and starting to place the glue by opening a glue placing valve at the bottom of a glue dissolving tank; after the glue is put, the glue barrel is placed in a heat insulation area, a power supply and a sensor are plugged, and a body or cap glue solution state marking sheet is filled and written respectively;
keeping the temperature: respectively setting the body heat preservation temperature of 53 ℃ and the cap heat preservation temperature of 51 ℃ according to the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line, and detecting whether the actual temperature of the glue solution of the heat preservation barrel meets the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line every 2 hours by using a thermometer to ensure that the glue solution is placed for 18-24 hours for standby application;
step S2: preparing a capsule:
preparing: adjusting the indoor temperature and humidity of the host;
operation II:
when the temperature of the glue dipping tank reaches the set temperature, glue is released, and the actual temperature of the glue solution of the glue barrel is 1.0 ℃ higher than that of the glue solution of the glue tank; then, glue discharging is started, the temperature of the glue tank is measured after the glue bundle is discharged for 30 minutes, and the actual temperature of the glue solution of the glue tank is adjusted according to the viscosity of the glue solution;
after glue dipping is started, the temperature of the glue groove is adjusted according to the wall thickness, the position of the glue groove is adjusted according to the top thickness, the wall thickness and the top thickness meet the quality standard, and the wall thickness is adjusted in sequence of firstly adjusting the wall thickness and then adjusting the top thickness;
adjusting attention items:
the actual temperature of the glue solution in the glue tank, the environmental temperature of the front chamber and the rear chamber, and the actual temperature of the glue solution in the glue barrel are 1 ℃ higher than the actual temperature of the glue solution in the glue tank;
quality control points:
the inspectors are capsule manufacturing personnel and QA in class, and the wall thickness, the top thickness, the light inspection, the cut, the length, the grain weight, the size and the moisture detection are carried out on the capsule.
In this embodiment, in step S1, the gelling agent is low acyl gellan gum; in the step S1, when the hollow capsule is an opaque capsule, the auxiliary material is titanium dioxide mother liquor, and when the hollow capsule is a colored capsule, the auxiliary material is pigment liquor; in step S1, the opening and closing pressure of the vacuum pump valve is 0.060-0.075 MPa; in step S2, the main indoor temperature/humidity adjustment standard is the front room temperature: 22.5 ± 0.5 ℃, relative humidity: 50-65%; rear chamber temperature: 31.5 ± 0.5 ℃, relative humidity: 30 to 45 percent.
In this embodiment, in step S2, before the glue dipping starts, the on-line viscometer is started to measure the viscosity, the viscosity of the cap glue solution is controlled at 2200-; in step S2, the relative viscosity of the glue solution in the glue dipping tank: 2200-2400cps, checking the circulating water temperature of the glue groove every 2 hours, controlling the temperature of the cap glue groove between 51 and 53 ℃, controlling the temperature of the body glue groove between 50 and 52 ℃, and controlling the motor speed: 20-30 r/min.
In this embodiment, in step S2, in the detection of the appearance quality, the frequency of the inspection is: every 30 minutes, the appearance quality detection method comprises the following steps: firstly, determining whether the wall thickness and the top thickness meet the standard, and then performing light inspection on a light inspection table, wherein the defects of uneven thickness, black spots, sand holes, bubbles, crisp chips and plum blossom heads are not more than 1 per thousand; the cutting requirement is free of gaps and glue threads; the length deviation of the cap A and the body B is less than or equal to +/-0.4 mm, and defective products are not more than 1 per thousand; the length and the length of the hollow capsule are sleeved, the capsule is inserted and split, and the defective product of a single capsule is not more than 1 per thousand; particle weight, size and moisture: the requirements of the middle control inspection regulation should be met.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.
Claims (8)
1. A preparation method of a hydroxypropyl methylcellulose and seaweed polysaccharide hollow capsule is characterized by comprising the following steps:
step S1: sol:
adding water: adding a proper amount of purified water into the sol tank according to the requirement of batch production instructions;
feeding, heating, feeding and stirring:
feeding tailings: according to the requirement of batch production instructions, adding metered purified water into a sol tank, starting a stirring motor, slowly adding weighed tailings into the sol tank, and starting to heat after stirring is stopped;
and (3) heating: setting the temperature controller at 95 ℃, starting a steam main valve, setting steam to be heated, and starting a steam electric control valve; steam enters through an upper interlayer pipeline of the sol tank, flows out through a lower interlayer pipeline, and is changed into condensed water through an output valve to be discharged;
feeding raw materials and auxiliary materials and stirring: after the temperature of the gel liquid in the gel dissolving tank is heated to 95 ℃, slowly adding the weighed hydroxypropyl methylcellulose moderate carrageenan into the gel dissolving tank, stirring for 20 minutes until the weighed hydroxypropyl methylcellulose moderate carrageenan is uniform, slowly adding the weighed auxiliary materials into the gel dissolving tank according to the requirement of a production order list, and stirring uniformly;
stirring at high temperature, vacuumizing, and dissolving:
after all raw materials, auxiliary materials and tailings are fed according to the production instruction list, heating to 95 ℃ for sol, opening a vacuum pump valve switch, and vacuumizing while stirring to remove bubbles: when the liquid level rises to about 20cm away from the vacuum air suction port, half opening the exhaust valve to lower the liquid level; repeating the action for 4-5 times until the liquid level does not rise any more, closing the vacuum valve, and stopping vacuumizing; keeping the temperature of the glue solution in the glue dissolving tank at 95 ℃, stirring at high temperature for 60 minutes, and then cooling;
cooling and stirring: setting a sol filling temperature controller to be 50 ℃, setting a hot water tank temperature controller to cool hot water at 35 ℃, and when an electric control hot water valve is opened, circulating water for cooling flows from a lower interlayer pipeline of the glue pot to an upper interlayer pipeline of the glue pot through a hot water tank and then returns to the hot water tank to realize heat dissipation and cooling of the circulating water; adjusting the flow rate to slowly reduce the temperature of the glue solution to a specified temperature, and stirring while reducing the temperature to ensure that the glue solution is uniform;
stirring at constant temperature: when the temperature of the glue solution is reduced to 50 ℃, continuously stirring for 60 minutes at constant temperature to ensure that the glue solution is uniformly dispersed;
sixthly, viscosity measurement-correction-glue release: after stirring for 60 minutes at constant temperature, turning off the stirring motor, and stopping stirring; taking a proper amount of glue solution by using a 500ml beaker, placing the glue solution in a 50 ℃ constant temperature water bath, accurately measuring the viscosity value of the glue solution by using an online viscometer, controlling the time to be 10 minutes, wherein the viscosity value requirement meets 2300-2400cps, and if the viscosity value of the glue solution is not in a specified range, adding a certain proportion of 60 ℃ hot water and stirring for 30 minutes to perform viscosity correction until the viscosity value meets the requirement, and filling the original record; when the viscosity value correction of the glue solution meets the requirement, connecting a glue placing pipe, placing the glue placing pipe into a heat-insulated glue barrel, ensuring that the water level and the water temperature of an interlayer of the heat-insulated barrel of the glue barrel meet the requirement, and starting to place the glue by opening a glue placing valve at the bottom of a glue dissolving tank; after the glue is put, the glue barrel is placed in a heat insulation area, a power supply and a sensor are plugged, and a body or cap glue solution state marking sheet is filled and written respectively;
keeping the temperature: respectively setting the body heat preservation temperature of 53 ℃ and the cap heat preservation temperature of 51 ℃ according to the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line, and detecting whether the actual temperature of the glue solution of the heat preservation barrel meets the actual temperature requirements of the glue solution of the upper body and the cap glue barrel of the production line every 2 hours by using a thermometer to ensure that the glue solution is placed for 18-24 hours for standby application;
step S2: preparing a capsule:
preparing: adjusting the indoor temperature and humidity of the host;
operation II:
when the temperature of the glue dipping tank reaches the set temperature, glue is released, and the actual temperature of the glue solution of the glue barrel is 1.0 ℃ higher than that of the glue solution of the glue tank; then, glue discharging is started, the temperature of the glue tank is measured after the glue bundle is discharged for 30 minutes, and the actual temperature of the glue solution of the glue tank is adjusted according to the viscosity of the glue solution;
after glue dipping is started, the temperature of the glue groove is adjusted according to the wall thickness, the position of the glue groove is adjusted according to the top thickness, the wall thickness and the top thickness meet the quality standard, and the wall thickness is adjusted in sequence of firstly adjusting the wall thickness and then adjusting the top thickness;
adjusting attention items:
the actual temperature of the glue solution in the glue tank, the environmental temperature of the front chamber and the rear chamber, and the actual temperature of the glue solution in the glue barrel are 1 ℃ higher than the actual temperature of the glue solution in the glue tank;
quality control points:
the inspectors are capsule manufacturing personnel and QA in class, and the wall thickness, the top thickness, the light inspection, the cut, the length, the grain weight, the size and the moisture detection are carried out on the capsule.
2. The method for preparing hydroxypropyl methylcellulose and algal polysaccharide empty capsules according to claim 1, wherein in step S1, the auxiliary material is titanium dioxide mother liquor when the empty capsule is opaque, and the auxiliary material is pigment liquor when the empty capsule is colored.
3. The method for preparing hydroxypropyl methylcellulose and algal polysaccharide empty capsules according to claim 1, wherein the pressure of the vacuum pump valve is 0.060-0.075MPa in step S1.
4. The method for preparing hydroxypropyl methylcellulose and algal polysaccharide empty capsules according to claim 1, wherein in step S2, the main indoor temperature and humidity adjusting standard is the front chamber temperature: 22.5 ± 0.5 ℃, relative humidity: 50-65%; rear chamber temperature: 31.5 ± 0.5 ℃, relative humidity: 30 to 45 percent.
5. The method for preparing hydroxypropyl methylcellulose and algal polysaccharide hollow capsules according to claim 1, wherein in step S2, before the start of dipping, the on-line viscometer is started to measure the viscosity, the viscosity of the cap gum solution is controlled to 2200 centipoises, the viscosity of the body gum solution is controlled to 2300 centipoises, and the dipping is started after the viscosity is stabilized for 5-15 minutes.
6. The method for preparing hydroxypropyl methylcellulose and algal polysaccharide empty capsules according to claim 1, wherein in step S2, the relative viscosity of the dipping tank gelatin solution is: 2200-2400cps, checking the circulating water temperature of the glue groove every 2 hours, controlling the temperature of the cap glue groove between 51 and 53 ℃, controlling the temperature of the body glue groove between 50 and 52 ℃, and controlling the motor speed: 20-30 r/min.
7. The method for preparing an empty capsule of hydroxypropylmethylcellulose and algal polysaccharide according to claim 1, wherein in the step S2, the inspection frequency is every 30 minutes at the time of the appearance quality inspection.
8. The preparation method of the hydroxypropyl methylcellulose and algal polysaccharide empty capsule according to claim 7, which is characterized in that the appearance quality detection method comprises the following steps: determining whether the wall thickness and the top thickness meet the standard, and then performing light inspection on a light inspection table, wherein the defects of uneven thickness, black spots, sand holes, bubbles, crisp chips and plum blossom heads are not more than 1 per thousand; the cutting requirement is free of gaps and glue threads; the length deviation of the cap A and the body B is less than or equal to +/-0.4 mm, and defective products are not more than 1 per thousand; the length and the length of the hollow capsule are matched, the capsule is split, and the defective rate of a single capsule is not more than 1 per thousand.
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