CN105380924B - A kind of chitosan oligosaccharide capsule agent and preparation method thereof - Google Patents
A kind of chitosan oligosaccharide capsule agent and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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Abstract
The invention belongs to pharmaceutical preparations technology field, and in particular to a kind of chitosan oligosaccharide capsule agent and preparation method thereof.The present invention, which provides chitosan oligosaccharide capsule agent, includes content and softgel shell, and the content is mainly made up of chitosan oligosaccharide, microcrystalline cellulose, binder, calcium stearate, ethanol and superfine silica gel powder；The softgel shell is mainly made up of hydroxypropul starch, xanthans, thickener, plasticizer and water.Chitosan oligosaccharide capsule agent free from extraneous odour provided by the invention, outward appearance is clean and tidy, smooth, its content uniformity meets the related rule of Chinese Pharmacopoeia to solubility, and the capsule also has preferable sealing and inoxidizability, can effectively solve the problems, such as that chitosan oligosaccharide is easy to oxidation and the moisture absorption, be advantageous to the long-term preservation of chitosan oligosaccharide.
Description
Technical field
The invention belongs to pharmaceutical preparations technology field, and in particular to a kind of chitosan oligosaccharide capsule agent and preparation method thereof.
Background technology
Chitosan oligosaccharide（chtiosnaoligosaccharide,COS）Glucosamine and 2-Acetamido-2-deoxy-D-glucose with β-
The homopolymer or heteropolymer that 1,4 glycosidic bonds are formed by connecting.COS is unique a large amount of existing alkaline polysaccharides in natural sugar, except tool
Outside the property for having similar chitosan, it also has, and viscosity is low, and good water solubility, molecular weight is small, easily absorbs and degradable etc.
Advantage, its bioactivity and functional character are all more superior than chitosan.Numerous studies show that COS has regulation blood pressure and blood lipoid,
Anti-oxidant, anti-infective, strengthen immunity and the function such as antitumor, are a kind of ideal bioactive substances, are had wide
Medical applications prospect.
Chinese patent CN103316031B discloses the Weight-reducing and lipid-lowering application of chitosan oligosaccharide, the chitosan oligosaccharide control body weight,
Reducing body fat and when reduce in serum, there is significant application to imitate in terms of the content of T-CHOL and LDL-C
Fruit, show chitosan oligosaccharide with significant fat-reducing, fat-reducing effect, while also have and alleviate fatty liver, the blood fat in reduction serum
Function.
Chen Jian has delivered entitled " chitosan oligosaccharide, Glucosamine anti-obesity activity and a load capsaicine chitosan microball intestines
The paper of the research of molten ", the paper shows that chitosan oligosaccharide has preferable fat-reducing effect, but also has and have no toxic side effect, inhale
The advantages of fast and raw compatibility is good is received, is a kind of preferable slimming medicine.
However, due to chitosan oligosaccharide have low molecular weight, the easy moisture absorption, it is oxidizable the characteristics of, greatly limit it and protecting
Application in strong product or medicine field.At present, in terms of the application of chitosan oligosaccharide focuses primarily upon crops.Chinese patent
CN102613197B discloses the purposes that chitosan oligosaccharide is applied to premature senescence resistance, and the chitosan oligosaccharide is capable of the morning of effectively preventing crop
Decline, ensure that the stable yields of agricultural increases income.Chinese patent CN101818181B discloses the method for preparing agricultural chitosan oligosaccharide by enzymolysis and contained
There is the crop nutrition preparation of chitosan oligosaccharide, the nutritional preparation can not only provide nutrition for crop, stimulate plant growth, but also can
To suppress the breeding of harmful bacteria, the resistance against diseases of crop itself is improved.
Therefore, it is to promote chitosan oligosaccharide in health care to study and output the chitosan oligosaccharide formulation that a kind of stability is good, inoxidizability is high
Effective way is applied in product or medicine field.
The content of the invention
In order to solve low molecular weight existing for chitosan oligosaccharide in the prior art, the easy moisture absorption, it is oxidizable the defects of, it is of the invention
Purpose is to provide a kind of chitosan oligosaccharide capsule agent and preparation method thereof, to solve drawbacks described above.
The invention provides a kind of chitosan oligosaccharide capsule agent, including content and softgel shell, the content includes following component
And its percentage by weight：
Chitosan oligosaccharide 80-100%, microcrystalline cellulose 0-6%, binder 0-5%, calcium stearate 0-3%, ethanol 0-4% and micro mist silicon
Glue 0-2%；
The softgel shell includes following component and its parts by weight：
Hydroxypropul starch 4-10 parts, xanthans 2-6 parts, thickener 4-8 parts, plasticizer 3-6 parts and water 10-20 parts.
Further, the content includes following component and its percentage by weight：
Chitosan oligosaccharide 80-92%, microcrystalline cellulose 2-6%, binder 2-5%, calcium stearate 1-3%, ethanol 2-4% and micro mist silicon
Glue 1-2%.
Further, the content includes following component and its percentage by weight：
Chitosan oligosaccharide 85.5%, microcrystalline cellulose 4%, binder 4%, calcium stearate 2%, ethanol 3% and superfine silica gel powder 1.5%.
Further, the binder is the povidone solution that concentration is 5%, and the ethanol is absolute ethyl alcohol.
Further, the softgel shell includes following component and its parts by weight：
16 parts of 8 parts of hydroxypropul starch, 4 parts of xanthans, 5 parts of thickener, 4 parts of plasticizer and water.
Further, the thickener by guar gum and propylene glycol alginate by weight 1-2:3-4 is formed, preferably
Ground, the thickener is by guar gum and propylene glycol alginate by weight 1.2:3.5 composition.
Further, the plasticizer by glycerine and triethyl citrate by weight 2-4:1-3 is formed, it is preferable that institute
Plasticizer is stated by glycerine and triethyl citrate by weight 3.5:2 compositions.
It is 5% povidone solution as binder that Capsule content provided by the invention, which uses concentration, can be improved
The uniformity of grain, being not in can not granulating, grain be loose or the phenomenon of caking., can be to prevent from absolute ethyl alcohol as wetting agent
The phenomenon that only chitosan oligosaccharide pasty state occurs or clumped together.The each component compatibility of Capsule content provided by the invention is reasonable, prepares
Obtained content is dry, elastic appropriateness, and moisture is qualified, meets relevant regulations of the Chinese Pharmacopoeia to Capsule content.
The molecular formula of hydroxypropul starch in softgel shell provided by the invention is C3H8O2x, and No. CAS is 9049-76-7, its
High with stability, the advantages of dilatancy and good film forming characteristics, xanthans has the heat endurance that viscosity is high, good and soda acid steady
The advantages of qualitative, it is a kind of ideal biogum.Hydroxypropul starch can improve hydroxypropyl shallow lake with xanthans compounding use
The gelation and gelling temp of powder, be advantageous to the film forming of hydroxypropul starch.
Guar gum in softgel shell provided by the invention is a kind of nonionic galactomannans, and it has preferable water
Dissolubility, and the advantages of higher viscosity is presented under low quality fraction.Propylene glycol alginate is the sea extracted from natural seaweed
Alginic acid deep processing is made, its in an acidic solution will not gelation, be a kind of thickener of environment-friendly type.Guar gum and alginic acid third
Diol ester is used in combination in the range of certain proportion, can greatly enhance the thickening power of propylene glycol alginate.Glycerine has glutinous
Low, easily scattered, the characteristics of compatibility is good is spent, and the advantages of triethyl citrate has dissolubility strong and fungus resistance is good.Glycerine with
Triethyl citrate is used in combination in the range of certain proportion, has significant plasticization effect.
Softgel shell each component compatibility provided by the invention is reasonable, and for the softgel shell being prepared without foreign odor, outward appearance is clean and tidy, does not stick
Knot, deformation, seepage or softgel shell fracture phenomena, and good airproof performance, inoxidizability are high, greatly improve the stabilization of capsule
Property, be advantageous to the preservation of the capsule.
In addition, present invention also offers a kind of preparation method of chitosan oligosaccharide capsule agent, comprise the following steps：
Chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and superfine silica gel powder are ground into fine powder by S1, add binder and ethanol
It is well mixed, 18-25 mesh sieves are crossed, obtain fine powder；
The fine powder that S2 obtains step S1 carries out wet granulation, and the temperature of the wet granulation is 22-28 DEG C, and humidity is
35-45%, dried after granulation to moisture and be less than 10%, obtain content；
Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, in temperature
To dry 4-5h under conditions of 55-60 DEG C, carry out dipping in glue at being then 50 DEG C in temperature, dry, be stripped, cutting, fit, obtain capsule
Shell；
The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
Compared with prior art, chitosan oligosaccharide capsule agent provided by the invention has the advantage that：
（1）Chitosan oligosaccharide capsule agent free from extraneous odour provided by the invention, outward appearance is clean and tidy, smooth, and solubility is high, beneficial to drug effect
Performance, be a kind of ideal chitosan oligosaccharide capsule agent；
（2）Chitosan oligosaccharide capsule agent good airproof performance provided by the invention, inoxidizability are high, can effectively solve chitosan oligosaccharide
The problem of being easy to oxidation and the moisture absorption, is advantageous to the long-term preservation of chitosan oligosaccharide.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art according to the present invention basic thought, various modifications may be made or improve, but without departing from this
The basic thought of invention, within the scope of the present invention.
Embodiment 1, a kind of chitosan oligosaccharide capsule agent
The content is 100% chitosan oligosaccharide；
The softgel shell includes following component and its parts by weight：
16 parts of 8 parts of hydroxypropul starch, 4 parts of xanthans, 5 parts of thickener, 4 parts of plasticizer and water；The thickener is by Guar
Bean gum and propylene glycol alginate are by weight 1.2:3.5 compositions, the plasticizer by glycerine and triethyl citrate by weight
3.5:2 compositions.
Preparation method：
Chitosan oligosaccharide is ground into fine powder by S1, is crossed 20 mesh sieves, is obtained fine powder；
The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, system
Dried after grain to moisture and be less than 10%, obtain content；
Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, in temperature
To dry 4h under conditions of 60 DEG C, then it is 50 DEG C in temperature and writes into row and dip in glue, dry, be stripped, cutting, fit, obtain softgel shell；
The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
Embodiment 2, a kind of chitosan oligosaccharide capsule agent
The content includes following component and its percentage by weight：
Chitosan oligosaccharide 92%, the povidone solution 2% of microcrystalline cellulose 2%, 5%, calcium stearate 1%, absolute ethyl alcohol 2% and micro mist silicon
Glue 1%；
The softgel shell includes following component and its parts by weight：
10 parts of 4 parts of hydroxypropul starch, 2 parts of xanthans, 4 parts of thickener, 3 parts of plasticizer and water；The thickener is by Guar
Bean gum and propylene glycol alginate are by weight 1:4 compositions, the plasticizer is by glycerine and triethyl citrate by weight 2:3 groups
Into.
Preparation method：
Chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and superfine silica gel powder are ground into fine powder by S1, add 5% PVP it is molten
Liquid and absolute ethyl alcohol are well mixed, and are crossed 20 mesh sieves, are obtained fine powder；
The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, system
Dried after grain to moisture and be less than 10%, obtain content；
Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, in temperature
To dry 4h under conditions of 60 DEG C, then it is 50 DEG C in temperature and writes into row and dip in glue, dry, be stripped, cutting, fit, obtain softgel shell；
The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
Embodiment 3, a kind of chitosan oligosaccharide capsule agent
The content includes following component and its percentage by weight：
Chitosan oligosaccharide 85.5%, the povidone solution 4% of microcrystalline cellulose 4%, 5%, calcium stearate 2%, absolute ethyl alcohol 3% and micro mist
Silica gel 1.5%；
The softgel shell includes following component and its parts by weight：
16 parts of 8 parts of hydroxypropul starch, 4 parts of xanthans, 5 parts of thickener, 4 parts of plasticizer and water；The thickener is by Guar
Bean gum and propylene glycol alginate are by weight 1.2:3.5 compositions, the plasticizer by glycerine and triethyl citrate by weight
3.5:2 compositions.
Preparation method is similar to Example 2.
Embodiment 4, a kind of chitosan oligosaccharide capsule agent
The content includes following component and its percentage by weight：
Chitosan oligosaccharide 80%, the povidone solution 5% of microcrystalline cellulose 6%, 5%, calcium stearate 3%, absolute ethyl alcohol 4% and micro mist silicon
Glue 2%；
The softgel shell includes following component and its parts by weight：
20 parts of 10 parts of hydroxypropul starch, 6 parts of xanthans, 8 parts of thickener, 6 parts of plasticizer and water；The thickener is by Guar
Bean gum and propylene glycol alginate are by weight 2:3 compositions, the plasticizer is by glycerine and triethyl citrate by weight 4:1 group
Into.
Preparation method is similar to Example 2.
Comparative example 1, a kind of chitosan oligosaccharide capsule agent
The component and its percentage by weight of the content such as embodiment 3.
The component and its parts by weight of the softgel shell be：The thickener by guar gum and propylene glycol alginate by weight
Than 3:2 compositions, remaining component such as embodiment 3.
Preparation method is similar to Example 2.
Comparative example 2, a kind of chitosan oligosaccharide capsule agent
The component and its percentage by weight of the content such as embodiment 3.
The component and its parts by weight of the softgel shell be：The plasticizer is by glycerine and triethyl citrate by weight 1:
4 compositions, remaining component such as embodiment 3.
Preparation method is similar to Example 2.
Test example one, the quality testing experiment of chitosan oligosaccharide capsule agent
1st, test material：Shell prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 is few
Carbohydrate gum wafer.
2nd, detection method：
With reference to《Chinese Pharmacopoeia version two in 2010》Detection method, to embodiment 1, embodiment 2, embodiment 3, embodiment
4th, the content material state of chitosan oligosaccharide capsule agent prepared by comparative example 1 and comparative example 2 and moisture are measured, while few to shell
Outward appearance, stink, content uniformity and the solubility of carbohydrate gum wafer are detected, and wherein solubility is using pulpboard method measurement chitosan oligosaccharide glue
Dissolution rate of the wafer in 45min.
3rd, result of the test：
Result of the test is as shown in table 1.
The quality testing result of the test of the chitosan oligosaccharide capsule agent of table 1
As shown in Table 1, the content material state of chitosan oligosaccharide capsule agent prepared by 1-4 of the embodiment of the present invention is dry, elastic appropriateness,
Moisture is less than 9.0%, and the capsule free from extraneous odour, outward appearance is clean and tidy, without cohere, deform, seepage or softgel shell fracture phenomena,
Its content uniformity and solubility meet the relevant regulations of Chinese Pharmacopoeia, and capsule prepared by comparative example 1 and comparative example 2 is outer
Sight has bumps, have cohere, deform, seepage or softgel shell fracture phenomena, dissolution rate is less than 90% in 45min, do not meet middle traditional Chinese medicines
The relevant regulations of allusion quotation, illustrate that capsule agent prescription provided by the invention is reasonable, product quality can be greatly improved, promote chitosan oligosaccharide
The promotion and application of capsule.
Test example two, the accelerated test of chitosan oligosaccharide capsule agent
1st, test material：Shell prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2
Oligosaccharides capsule.
2nd, test method：
With reference to《Two annex XIX C of Chinese Pharmacopoeia version in 2010》Test method, to embodiment 1, embodiment 2, implement
Chitosan oligosaccharide capsule agent prepared by example 3, embodiment 4, comparative example 1 and comparative example 2 carries out accelerated test.
3rd, result of the test：
Result of the test such as table 2.
The accelerated test result of the chitosan oligosaccharide capsule agent of table 2
As shown in Table 2, the chitosan oligosaccharide capsule agent that prepared by 1-4 of the embodiment of the present invention is 40 DEG C ± 2 DEG C, relative humidity in temperature
To place 6 months under conditions of 75% ± 5%, its indices meets quality requirement of the Chinese Pharmacopoeia to capsule, and contrasts
The stability of chitosan oligosaccharide capsule agent prepared by example 1 and comparative example 2 is poorer than chitosan oligosaccharide capsule agent prepared by embodiment 1-4, explanation
Chitosan oligosaccharide capsule agent prescription provided by the invention is reasonable, greatly improves the stability of chitosan oligosaccharide capsule agent.
Test example three, the long term test of chitosan oligosaccharide capsule agent
1st, test material：Chitosan oligosaccharide capsule agent prepared by embodiment 1, embodiment 2, embodiment 3 and embodiment 4.
2nd, test method：
With reference to《Two annex XIX C of Chinese Pharmacopoeia version in 2010》Test method, to embodiment 1, embodiment 2, implement
Chitosan oligosaccharide capsule agent prepared by example 3 and embodiment 4 carries out long term test.
3rd, result of the test：
Result of the test such as table 3.
The long-term test results of the chitosan oligosaccharide capsule agent of table 3
As shown in Table 3, the chitosan oligosaccharide capsule agent that prepared by 1-4 of the embodiment of the present invention is 25 DEG C ± 2 DEG C, relative humidity in temperature
To place 12 months under conditions of 60% ± 10%, its indices meets quality requirement of the Chinese Pharmacopoeia to capsule, explanation
Capsule stability provided by the invention is high, and moisture effect is good, is advantageous to the preservation of the capsule.
Claims (4)
- A kind of 1. chitosan oligosaccharide capsule agent, it is characterised in that including content and softgel shell, the content include following component and its Percentage by weight：The content is 100% chitosan oligosaccharide；The softgel shell includes following component and its parts by weight：Hydroxypropyl forms sediment 16 parts of 8 parts of powder, 4 parts of xanthans, 5 parts of thickener, 4 parts of plasticizer and water；The thickener is by guar gum and alginate propylene glycol Ester is by weight 1.2:3.5 compositions, the plasticizer is by glycerine and triethyl citrate by weight 3.5:2 compositions；The preparation method of the capsule is as follows：Chitosan oligosaccharide is ground into fine powder by S1, is crossed 20 mesh sieves, is obtained fine powder；The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, after granulation Dry to moisture and be less than 10%, obtain content；Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, and is 60 in temperature 4h is dried under conditions of DEG C, carries out dipping in glue at being then 50 DEG C in temperature, dries, be stripped, cutting, fit, obtain softgel shell；The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
- A kind of 2. chitosan oligosaccharide capsule agent, it is characterised in that including content and softgel shell, the content include following component and its Percentage by weight：Chitosan oligosaccharide 92%, the povidone solution 2% of microcrystalline cellulose 2%, 5%, calcium stearate 1%, absolute ethyl alcohol 2% and micro- Powder silica gel 1%；The softgel shell includes following component and its parts by weight：4 parts of hydroxypropul starch, 2 parts of xanthans, 4 parts of thickener, 10 parts of 3 parts of plasticizer and water；The thickener is by guar gum and propylene glycol alginate by weight 1:4 compositions, the plasticising Agent is by glycerine and triethyl citrate by weight 2:3 compositions；The preparation method of the capsule is as follows：Chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and superfine silica gel powder are ground into fine powder by S1, add 5% povidone solution and Absolute ethyl alcohol is well mixed, and is crossed 20 mesh sieves, is obtained fine powder；The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, after granulation Dry to moisture and be less than 10%, obtain content；Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, and is 60 in temperature 4h is dried under conditions of DEG C, carries out dipping in glue at being then 50 DEG C in temperature, dries, be stripped, cutting, fit, obtain softgel shell；The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
- A kind of 3. chitosan oligosaccharide capsule agent, it is characterised in that including content and softgel shell, the content include following component and its Percentage by weight：Chitosan oligosaccharide 85.5%, the povidone solution 4% of microcrystalline cellulose 4%, 5%, calcium stearate 2%, the and of absolute ethyl alcohol 3% Superfine silica gel powder 1.5%；The softgel shell includes following component and its parts by weight：8 parts of hydroxypropul starch, 4 parts of xanthans, thickener 5 16 parts of part, 4 parts of plasticizer and water；The thickener is by guar gum and propylene glycol alginate by weight 1.2:3.5 compositions, institute Plasticizer is stated by glycerine and triethyl citrate by weight 3.5:2 compositions；The preparation method of the capsule is as follows：Chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and superfine silica gel powder are ground into fine powder by S1, add 5% povidone solution and Absolute ethyl alcohol is well mixed, and is crossed 20 mesh sieves, is obtained fine powder；The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, after granulation Dry to moisture and be less than 10%, obtain content；Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, and is 60 in temperature 4h is dried under conditions of DEG C, carries out dipping in glue at being then 50 DEG C in temperature, dries, be stripped, cutting, fit, obtain softgel shell；The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
- A kind of 4. chitosan oligosaccharide capsule agent, it is characterised in that including content and softgel shell, the content include following component and its Percentage by weight：Chitosan oligosaccharide 80%, the povidone solution 5% of microcrystalline cellulose 6%, 5%, calcium stearate 3%, absolute ethyl alcohol 4% and micro- Powder silica gel 2%；The softgel shell includes following component and its parts by weight：10 parts of hydroxypropul starch, 6 parts of xanthans, 8 parts of thickener, 20 parts of 6 parts of plasticizer and water；The thickener is by guar gum and propylene glycol alginate by weight 2:3 compositions, the plasticising Agent is by glycerine and triethyl citrate by weight 4:1 composition；The preparation method of the capsule is as follows：Chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and superfine silica gel powder are ground into fine powder by S1, add 5% povidone solution and Absolute ethyl alcohol is well mixed, and is crossed 20 mesh sieves, is obtained fine powder；The fine powder that S2 obtains step S1 carries out wet granulation, 25 DEG C of the temperature of the wet granulation, humidity 40%, after granulation Dry to moisture and be less than 10%, obtain content；Hydroxypropul starch is ground into fine powder by S3, is added xanthans, thickener, plasticizer and water and is well mixed, and is 60 in temperature 4h is dried under conditions of DEG C, carries out dipping in glue at being then 50 DEG C in temperature, dries, be stripped, cutting, fit, obtain softgel shell；The obtained contents of step S2 are filled in the softgel shell that step S3 is obtained by S4, and capsule is sealed, produced.
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| PCT/CN2016/102114 WO2017107628A1 (en) | 2015-12-24 | 2016-10-14 | Chitosan oligosaccharide capsule and method for preparation thereof |
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| CN105380924B (en) * | 2015-12-24 | 2018-01-16 | 广东药科大学 | A kind of chitosan oligosaccharide capsule agent and preparation method thereof |
| CN108186701A (en) * | 2018-02-08 | 2018-06-22 | 沈勇子 | A kind of chitosan oligosaccharide capsule and preparation method thereof |
| CN108553426B (en) * | 2018-06-01 | 2020-04-03 | 广东药科大学 | Chitosan dropping pill and preparation method thereof |
| CN108578374B (en) * | 2018-06-01 | 2020-04-03 | 广东药科大学 | Chitosan oligosaccharide granules and preparation method thereof |
| CN109316460B (en) * | 2018-09-26 | 2021-11-26 | 青岛大学 | Preparation method of polysaccharide polyelectrolyte hollow capsule and hollow capsule obtained by preparation method |
| WO2022194351A1 (en) | 2021-03-16 | 2022-09-22 | Symrise Ag | Active substance capsules |
| CN114376982B (en) * | 2022-01-18 | 2023-06-30 | 广东药科大学 | Chitosan oligosaccharide enteric-coated capsule as well as preparation method and application thereof |
| CN115212189A (en) * | 2022-03-30 | 2022-10-21 | 江南大学 | Nano-microsphere for improving oral bioavailability of chitosan oligosaccharide and preparation method thereof |
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| US20060292212A1 (en) * | 2002-12-16 | 2006-12-28 | Laurence Paris | Use of thickening agents for producing soft capsules and film production method |
| CN104586877A (en) * | 2015-02-10 | 2015-05-06 | 河北工业大学 | Chitosan oligosaccharide-containing pharmaceutical composition and applications thereof |
| CN104721167A (en) * | 2015-03-09 | 2015-06-24 | 湖南尔康制药股份有限公司 | Starch soft capsules |
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| CN101416979A (en) * | 2007-10-24 | 2009-04-29 | 中国科学院大连化学物理研究所 | Use of oligosaccharide in preparing medicine for treating tumor and inhibiting tumor metastasis |
| CN101744164B (en) * | 2009-12-29 | 2012-06-27 | 江西省三抗保健品有限公司 | Chitosan oligosaccharide capsule |
| CN105380924B (en) * | 2015-12-24 | 2018-01-16 | 广东药科大学 | A kind of chitosan oligosaccharide capsule agent and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060292212A1 (en) * | 2002-12-16 | 2006-12-28 | Laurence Paris | Use of thickening agents for producing soft capsules and film production method |
| CN104586877A (en) * | 2015-02-10 | 2015-05-06 | 河北工业大学 | Chitosan oligosaccharide-containing pharmaceutical composition and applications thereof |
| CN104721167A (en) * | 2015-03-09 | 2015-06-24 | 湖南尔康制药股份有限公司 | Starch soft capsules |
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