CN108186477A - A kind of whitening and moistening skin maintenance frost and preparation method thereof - Google Patents
A kind of whitening and moistening skin maintenance frost and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of whitening and moistening skin maintenance frost and preparation method thereof, the whitening and moistening skin maintenance frost is prepared by the raw material of following weight parts：25 parts of glycerine, 12 parts of 1,3 butanediol, 13 parts of biosurfactant, 14 parts of natto extract liquor, 43 53 parts of water, 13 parts of Co-Q10,0.05 0.15 parts of Licochalcone A, 0.5 1.5 parts of vitamin, 12 parts of lanolin, 14 parts of ester oil, 0.5 1.5 parts of ceramide, 12 parts of crude vegetal.The production method of whitening and moistening skin maintenance frost of the present invention, it is simple for process, it can be good at controlling product cost, active function is eliminated with efficient hydroxy radical, without any side effects, face and hand are wiped in external application, the fine and smooth skin of whitening while can have the unique effects such as moistening skin, anti-aging.
Description
Technical field
The present invention relates to cosmetic technical fields more particularly to a kind of whitening and moistening skin maintenance frost and preparation method thereof.
Background technology
The Cosmetic Market of China is the emerging market of whole world maximum, in short more than 20 years, China cosmetic row
Industry from small to large, grows from weak to strong, from simple extensive to lead in the development of science and technology, grouping management, the whole industry form one begin to take shape,
It is rich in the army of industrial workers of life vigor.
Chinese patent (application number：201611241507.1) disclose a kind of freckle removing and whitening moisturizing cosmetics formula and its system
Preparation Method, it includes the raw material of following mass fraction：10-50 parts of matrimony vine, 10-60 parts of tea-seed oil, 5-30 parts of the root of Dahurain angelica, grape seed oil
5-40 parts, 1-6 parts of peppermint oil, 1-6 parts of rose oil.Preparation method is by the root of Dahurain angelica and drying of Chinese wolfberry and grind into powder, takes one
A clean container, angelica dahurica powder and wolfberry fruit powder are put into container, and tea-seed oil, grape seed oil, thin is added in by definite quality number
Lotus oil, rose oil, stir evenly；Then container is placed on electric furnace and heated, keep 70-95 DEG C of temperature, continue 30-60 points
Clock is carried out in heating process continuing stirring, be cooled down after the completion of heating to get freckle removing and whitening moisturizing cosmetics.
Chinese patent (application number：201110035887.4) a kind of Daffodil whitening cream cosmetic is disclosed, by weight,
Including following raw material：3-5 parts of daffodil bulb extract, 6.1-11 parts of whitening agent；3.1-7.4 parts of thickener；Emollient 8-15
Part；1.5-5 parts of emulsifier；0.5-1 parts of anti-sensitizer；8.01-12.1 parts of moisturizer；0.1-0.3 parts of preservative；Essence 0.03-0.1
Part；With 75-110 parts of water.
As people’s lives level increasingly improves, to the quality requirements of the cosmetics such as beauty, skin-protection product also increasingly
It is high.Skin-protection product available on the market is although various, but many products are more or less added to some harmful objects
Matter：Such as bleaching powder, mercury, detergent, corrosive agent.Although these substances have short-term whitening, skin care effect to the skin of people,
If be used for a long time, skin can be made to form color spot instead, seriously, it could even be possible to causing human organ that lesion occurs.People
There is also a desire for superior moisturizing repair cream.
Invention content
The purpose of the present invention is to provide a kind of whitening and moistening skin maintenance frosts and preparation method thereof, and overcoming the prior art, there are upper
The problem of stating, it is good with skin compatibility, functional component in cosmetics can be promoted to penetrate epidermis, play skin nursing effect.
Technical solution is used by solving above-mentioned technical problem：
A kind of whitening and moistening skin maintenance frost, is prepared by the raw material of following weight parts：2-5 parts of glycerine, 1,3 butylene glycol 1-2
Part, 1-3 parts of biosurfactant, 1-4 parts of natto extract liquor, 43-53 parts of water, 1-3 parts of Co-Q10, Licochalcone A
0.05-0.15 parts, 0.5-1.5 parts of vitamin, 1-2 parts of lanolin, 1-4 parts of ester oil, 0.5-1.5 parts of ceramide, natural plants
It is 1-2 parts oily.
The crude vegetal is camellia caul-fat or wheat germ oil or evening primrose oil.
The preparation method of the natto extract liquor is：Natto be crushed into 10-30 mesh sieve, then add in natto weight 15-
In 25 times of glycerine water solution, ultrasonic extraction 20-60min is centrifuged, and is 50- in temperature with 200-500 mesh filter-cloth filterings
70 DEG C, vacuum degree to concentrate under 0.01-0.06MPa, obtain natto extract liquor.
The mass fraction of glycerine is 40-60wt% in the glycerine water solution.
The ultrasonic power of the ultrasonic extraction is 250-450W, supersonic frequency 25-45kHz.
The ester oil is Hamposyl L isopropyl ester or lauroyl glutamate dioctyldodecyl base ester.
The dodecyl sugar amide surface that the biosurfactant is modified for polyphenol surfactant and/or ethyoxyl
Activating agent.
The polyphenol surfactant is prepared by following methods：Take 95-105g tea polyphenols, 75-85g hexylamines, the 20-30g last of the ten Heavenly stems
Acyl chlorides is added in 180-220mL methanol, and being 35-55 DEG C in temperature stirs 15-25h by 60-180r/min of rotating speed, cold with ice water
But to 0 DEG C, 90-110g sodium borohydrides are added in, 40-90min are stirred by 60-180r/min of rotating speed, with 0.2-1mol/L hydrochloric acid
Adjust pH to 1-2, stirred by 30-90r/min of rotating speed to no Precipitation, filter and collect filter cake, filter cake ethyl alcohol with
Water washs 2-4 times respectively, and in the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa, dry 1.5-3.5h, obtains a product；
It is 1 in mass ratio by a product and methanol：(3-7) is mixed, in rotating speed under 30-90r/min stirrings, temperature rising reflux is to without white
Color Precipitation filters and collects filter cake, and filter cake ethyl alcohol and water wash 2-4 times respectively, is 40-50 DEG C, vacuum degree in temperature
For 2.5-5.5h dry under 100-150Pa, intermediate product is obtained；Intermediate product, methanol, diethylene glycol diglycidyl glycerin ether are pressed
Mass ratio is 1：(6-9)：(1-2) is mixed, the heating in water bath for reaction 20-25h at 70-80 DEG C, then vacuum distillation removal methanol,
In the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa dry 5-10h to get.
Preferably, the dodecyl sugar acyl that the biosurfactant is modified by polyphenol surfactant, ethyoxyl
Amine surfactant is 1 in mass ratio：(0.2-0.6) is formed.
The vitamin is vitamin A or vitamin E.
The production method of above-mentioned whitening and moistening skin maintenance frost, includes the following steps：
(1) 1,3-BDO, biosurfactant, natto extract liquor, water are added in water phase pot and are uniformly mixed,
65-85 DEG C is warming up to, obtains water phase material；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added
It in oil phase pot, is heated to 65-85 DEG C and is uniformly mixed, obtain oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and oil phase material is pumped under homogeneous, homogeneous 3-13 minutes at 65-85 DEG C,
Then 15-25 minutes are kept the temperature, be eventually adding Co-Q10 and be uniformly mixed to obtain the final product.
Technique effect：
The production method of whitening and moistening skin maintenance frost of the present invention, it is simple for process, it can be good at controlling product cost, there is height
The hydroxy radical of effect eliminates active function, without any side effects, and face and hand are wiped in external application, and the energy fine and smooth skin of whitening has simultaneously
The unique effects such as moistening skin, anti-aging.
Specific embodiment
Glycerine in embodiment, No. CAS：56-81-5.
1,3-BDO in embodiment, CAS：107-88-0.
Co-Q10 is provided by Xi'an Nan Si bio tech ltd in embodiment.
Licochalcone A in embodiment, CAS：58749-22-7.
Lanolin is the cosmetics-stage water solubility lanolin that Guangzhou Shi Ming Chemical Co., Ltd.s provide in embodiment.
Ceramide in embodiment, CAS：100403-19-8.
Camellia caul-fat is the superfine camellia caul-fat that Guangzhou Ya Dian cosmetics Co., Ltd provides in embodiment, and extracting method is cold
It squeezes.
Natto is the frozen dried natto that Shandong prepossessing appearance Food Co., Ltd provides in embodiment.
Hamposyl L isopropyl ester in embodiment, No. CAS：230309-38-3.
Hexylamine in embodiment, No. CAS：111-26-2.
Decanoyl chloride in embodiment, No. CAS：112-13-0.
Methanol in embodiment, No. CAS：67-56-1.
Sodium borohydride in embodiment, No. CAS：16940-66-2.
Ethyl alcohol in embodiment, No. CAS：64-17-5.
Diethylene glycol diglycidyl glycerin ether in embodiment, No. CAS：4206-61-5.
Vitamin E in embodiment, No. CAS：10191-41-0.
The model VME- that homogeneous emulsifying machine is provided for Guangzhou joint automated machine Science and Technology Ltd. in embodiment
The vacuum homogeneous emulsifying machine of 300L.
Tea polyphenols are provided by Shaanxi Hao Chen bio tech ltd in embodiment, and appearance is light green brown color or reddish brown
Color fine powder, polyphenol content 98wt%.
In embodiment ethyoxyl be modified dodecyl sugar acidamide surfactant according to application No. is
201410336291.1 Chinese patent in method shown in embodiment 6 prepare.
Embodiment 1
Whitening and moistening skin maintenance frost, is prepared by the raw material of following weight parts：3.5 parts of glycerine, 1.5 parts of 1,3 butylene glycol,
2 parts of biosurfactant, 2.5 parts of natto extract liquor, 45 parts of deionized water, 2 parts of Co-Q10,0.1 part of Licochalcone A,
0.8 part of vitamin, 1.5 parts of lanolin, 2.5 parts of ester oil, 0.9 part of ceramide, 1.5 parts of crude vegetal.
The crude vegetal is camellia caul-fat.
The preparation method of the natto extract liquor is：Natto be crushed into 20 mesh sieve, then add in 20 times of natto weight
In glycerine water solution, ultrasonic extraction 40min centrifuges 20min by 6000r/min of rotating speed, takes supernatant with 300 mesh filter clothes
Filtrate, in the case where temperature is 60 DEG C, vacuum degree is 0.02MPa is concentrated into the half of former filtrate volume, obtains natto by filtering
Extract liquor.
The mass fraction of glycerine is 45wt% in the glycerine water solution.
The ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 35kHz.
The ester oil is Hamposyl L isopropyl ester.
The biosurfactant is polyphenol surfactant.
The polyphenol surfactant is prepared by following methods：100g tea polyphenols, 80g hexylamines, 25g decanoyl chlorides is taken to add in
In 200mL methanol, it is 45 DEG C in temperature and 20h is stirred by 120r/min of rotating speed, be cooled to 0 DEG C with ice water, add in 100g boron hydrogen
Change sodium, 50min is stirred by 120r/min of rotating speed, with 0.5mol/L salt acid for adjusting pH to 1.5, stirred by 60r/min of rotating speed
It to no Precipitation, filters and collects filter cake, filter cake ethyl alcohol and water wash 3 times respectively, wash the use of ethyl alcohol or water every time
Amount is 20mL, and in the case where temperature is 45 DEG C, vacuum degree is 130Pa, dry 2.5h, obtains a product；By a product and methanol
It is 1 in mass ratio：5 mixing, in rotating speed under 60r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters and collects filter
Cake, filter cake ethyl alcohol and water wash 4 times respectively, and it is 20mL to wash ethyl alcohol or the dosage of water every time, are 45 DEG C, vacuum in temperature
It spends to dry 4h under 130Pa, obtains intermediate product；It is in mass ratio by intermediate product, methanol, diethylene glycol diglycidyl glycerin ether
1：7.5：1.2 mixing, the heating in water bath for reaction 23h at 75 DEG C, then vacuum distillation removal methanol, is 45 DEG C, vacuum in temperature
Spend is that 7h is dried under 130Pa to get polyphenol surfactant.
The vitamin is vitamin E.
The production method of above-mentioned whitening and moistening skin maintenance frost, includes the following steps：
(1) 1,3 butylene glycol, biosurfactant, natto extract liquor, deionized water are added in the water of homogeneous emulsifying machine
15min is stirred as 300r/min to be uniformly mixed, be warming up to 75 DEG C, obtain water phase material in phase pot using rotating speed；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added
In the oil phase pot of homogeneous emulsifying machine, it is heated to 75 DEG C and is uniformly mixed by 300r/min stirrings 15min of rotating speed, obtain oil phase material；
(3) 75 DEG C of water phase material is pumped into the emulsification pot of homogeneous emulsifying machine, is stirred under homogeneous for 300r/min in rotating speed
Be pumped into 75 DEG C of oil phase material, then homogeneous 7 minutes at 75 DEG C keep the temperature 20 minutes, be eventually adding Co-Q10 using rotating speed as
300r/min stirs 15min to get whitening and moistening skin maintenance frost.
Embodiment 2
Whitening and moistening skin maintenance frost, is prepared by the raw material of following weight parts：3.5 parts of glycerine, 1.5 parts of 1,3 butylene glycol,
2 parts of biosurfactant, 2.5 parts of natto extract liquor, 45 parts of deionized water, 2 parts of Co-Q10,0.1 part of Licochalcone A,
0.8 part of vitamin, 1.5 parts of lanolin, 2.5 parts of ester oil, 0.9 part of ceramide, 1.5 parts of crude vegetal.
The crude vegetal is camellia caul-fat.
The preparation method of the natto extract liquor is：Natto be crushed into 20 mesh sieve, then add in 20 times of natto weight
In glycerine water solution, ultrasonic extraction 40min centrifuges 20min by 6000r/min of rotating speed, takes supernatant with 300 mesh filter clothes
Filtrate, in the case where temperature is 60 DEG C, vacuum degree is 0.02MPa is concentrated into the half of former filtrate volume, obtains natto by filtering
Extract liquor.
The mass fraction of glycerine is 45wt% in the glycerine water solution.
The ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 35kHz.
The ester oil is Hamposyl L isopropyl ester.
The biosurfactant is polyphenol surfactant.
The polyphenol surfactant is prepared by following methods：100g tea polyphenols, 80g hexylamines is taken to add in 200mL methanol,
Be 45 DEG C in temperature and 20h stirred by 120r/min of rotating speed, be cooled to 0 DEG C with ice water, add in 100g sodium borohydrides, using rotating speed as
120r/min stirs 50min, with 0.5mol/L salt acid for adjusting pH to 1.5, is stirred by 60r/min of rotating speed to no Precipitation
Afterwards, it filtering and collects filter cake, filter cake ethyl alcohol and water wash 3 times respectively, and it is 20mL to wash ethyl alcohol or the dosage of water every time,
Temperature is 45 DEG C, vacuum degree is dry 2.5h under 130Pa, obtains a product；It is 1 in mass ratio by a product and methanol：5
Mixing, in rotating speed under 60r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters and collects filter cake, filter cake ethyl alcohol
It is washed respectively with water 4 times, it is 20mL to wash ethyl alcohol or the dosage of water every time, is done in the case where temperature is 45 DEG C, vacuum degree is 130Pa
Dry 4h, obtains intermediate product；It is 1 in mass ratio by intermediate product, methanol, diethylene glycol diglycidyl glycerin ether：7.5：It is 1.2 mixed
It closes, the heating in water bath for reaction 23h at 75 DEG C, then vacuum distillation removal methanol, in the case where temperature is 45 DEG C, vacuum degree is 130Pa
Dry 7h is to get polyphenol surfactant.
The vitamin is vitamin E.
The production method of above-mentioned whitening and moistening skin maintenance frost, includes the following steps：
(1) 1,3 butylene glycol, biosurfactant, natto extract liquor, deionized water are added in the water of homogeneous emulsifying machine
15min is stirred as 300r/min to be uniformly mixed, be warming up to 75 DEG C, obtain water phase material in phase pot using rotating speed；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added
In the oil phase pot of homogeneous emulsifying machine, it is heated to 75 DEG C and is uniformly mixed by 300r/min stirrings 15min of rotating speed, obtain oil phase material；
(3) 75 DEG C of water phase material is pumped into the emulsification pot of homogeneous emulsifying machine, is stirred under homogeneous for 300r/min in rotating speed
Be pumped into 75 DEG C of oil phase material, then homogeneous 7 minutes at 75 DEG C keep the temperature 20 minutes, be eventually adding Co-Q10 using rotating speed as
300r/min stirs 15min to get whitening and moistening skin maintenance frost.
Embodiment 3
Whitening and moistening skin maintenance frost, is prepared by the raw material of following weight parts：3.5 parts of glycerine, 1.5 parts of 1,3 butylene glycol,
2 parts of biosurfactant, 2.5 parts of natto extract liquor, 45 parts of deionized water, 2 parts of Co-Q10,0.1 part of Licochalcone A,
0.8 part of vitamin, 1.5 parts of lanolin, 2.5 parts of ester oil, 0.9 part of ceramide, 1.5 parts of crude vegetal.
The crude vegetal is camellia caul-fat.
The preparation method of the natto extract liquor is：Natto be crushed into 20 mesh sieve, then add in 20 times of natto weight
In glycerine water solution, ultrasonic extraction 40min centrifuges 20min by 6000r/min of rotating speed, takes supernatant with 300 mesh filter clothes
Filtrate, in the case where temperature is 60 DEG C, vacuum degree is 0.02MPa is concentrated into the half of former filtrate volume, obtains natto by filtering
Extract liquor.
The mass fraction of glycerine is 45wt% in the glycerine water solution.
The ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 35kHz.
The ester oil is Hamposyl L isopropyl ester.
The biosurfactant is the dodecyl sugar acidamide surfactant that ethyoxyl is modified.
The vitamin is vitamin E.
The production method of above-mentioned whitening and moistening skin maintenance frost, includes the following steps：
(1) 1,3 butylene glycol, biosurfactant, natto extract liquor, deionized water are added in the water of homogeneous emulsifying machine
15min is stirred as 300r/min to be uniformly mixed, be warming up to 75 DEG C, obtain water phase material in phase pot using rotating speed；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added
In the oil phase pot of homogeneous emulsifying machine, it is heated to 75 DEG C and is uniformly mixed by 300r/min stirrings 15min of rotating speed, obtain oil phase material；
(3) 75 DEG C of water phase material is pumped into the emulsification pot of homogeneous emulsifying machine, is stirred under homogeneous for 300r/min in rotating speed
Be pumped into 75 DEG C of oil phase material, then homogeneous 7 minutes at 75 DEG C keep the temperature 20 minutes, be eventually adding Co-Q10 using rotating speed as
300r/min stirs 15min to get whitening and moistening skin maintenance frost.
Embodiment 4
Whitening and moistening skin maintenance frost, is prepared by the raw material of following weight parts：3.5 parts of glycerine, 1.5 parts of 1,3 butylene glycol,
2 parts of biosurfactant, 2.5 parts of natto extract liquor, 45 parts of deionized water, 2 parts of Co-Q10,0.1 part of Licochalcone A,
0.8 part of vitamin, 1.5 parts of lanolin, 2.5 parts of ester oil, 0.9 part of ceramide, 1.5 parts of crude vegetal.
The crude vegetal is camellia caul-fat.
The preparation method of the natto extract liquor is：Natto be crushed into 20 mesh sieve, then add in 20 times of natto weight
In glycerine water solution, ultrasonic extraction 40min centrifuges 20min by 6000r/min of rotating speed, takes supernatant with 300 mesh filter clothes
Filtrate, in the case where temperature is 60 DEG C, vacuum degree is 0.02MPa is concentrated into the half of former filtrate volume, obtains natto by filtering
Extract liquor.
The mass fraction of glycerine is 45wt% in the glycerine water solution.
The ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 35kHz.
The ester oil is Hamposyl L isopropyl ester.
The dodecyl sugar amide surface activity that the biosurfactant is modified by polyphenol surfactant, ethyoxyl
Agent is 1 in mass ratio：0.25 mixes.
The polyphenol surfactant is prepared by following methods：100g tea polyphenols, 80g hexylamines, 25g decanoyl chlorides is taken to add in
In 200mL methanol, it is 45 DEG C in temperature and 20h is stirred by 120r/min of rotating speed, be cooled to 0 DEG C with ice water, add in 100g boron hydrogen
Change sodium, 50min is stirred by 120r/min of rotating speed, with 0.5mol/L salt acid for adjusting pH to 1.5, stirred by 60r/min of rotating speed
It to no Precipitation, filters and collects filter cake, filter cake ethyl alcohol and water wash 3 times respectively, wash the use of ethyl alcohol or water every time
Amount is 20mL, and in the case where temperature is 45 DEG C, vacuum degree is 130Pa, dry 2.5h, obtains a product；By a product and methanol
It is 1 in mass ratio：5 mixing, in rotating speed under 60r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters and collects filter
Cake, filter cake ethyl alcohol and water wash 4 times respectively, and it is 20mL to wash ethyl alcohol or the dosage of water every time, are 45 DEG C, vacuum in temperature
It spends to dry 4h under 130Pa, obtains intermediate product；It is in mass ratio by intermediate product, methanol, diethylene glycol diglycidyl glycerin ether
1：7.5：1.2 mixing, the heating in water bath for reaction 23h at 75 DEG C, then vacuum distillation removal methanol, is 45 DEG C, vacuum in temperature
Spend is that 7h is dried under 130Pa to get polyphenol surfactant.
The vitamin is vitamin E.
The production method of above-mentioned whitening and moistening skin maintenance frost, includes the following steps：
(1) 1,3 butylene glycol, biosurfactant, natto extract liquor, deionized water are added in the water of homogeneous emulsifying machine
15min is stirred as 300r/min to be uniformly mixed, be warming up to 75 DEG C, obtain water phase material in phase pot using rotating speed；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added
In the oil phase pot of homogeneous emulsifying machine, it is heated to 75 DEG C and is uniformly mixed by 300r/min stirrings 15min of rotating speed, obtain oil phase material；
(3) 75 DEG C of water phase material is pumped into the emulsification pot of homogeneous emulsifying machine, is stirred under homogeneous for 300r/min in rotating speed
Be pumped into 75 DEG C of oil phase material, then homogeneous 7 minutes at 75 DEG C keep the temperature 20 minutes, be eventually adding Co-Q10 using rotating speed as
300r/min stirs 15min to get whitening and moistening skin maintenance frost.
Test case 1
The removing free radical performance of whitening and moistening skin maintenance frost prepared by embodiment 1-4 is tested.
Remove free radical experiment：
Whitening and moistening skin maintenance frost is made into the sample solution that mass concentration is 0.5% with water, is tested.Take 0.05mol/
The Tris-HCl buffer solution 4.5mL of L pH=8.2,20min is preheated in 25 DEG C of water-baths.Add 1mL sample solutions and
The pyrogallol solution of 0.4mL 25mmol/L after mixing, reacts 5min in 25 DEG C of water-baths, adds in the HCl of 8mol/L
1.0mL terminates reaction.Reference is made with Tris-HCl buffer solutions, absorbance value is surveyed at 299nm.Blank control is replaced with 1mL water
For sample.Clearance rate (D) is calculated according to formula (2).
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100%.
In formula：A1 is the absorbance value of blank control；A2 is the absorbance value of sample.
Specific test result is shown in Table 1.
Table 1：Remove free radical test result table
Test case 2
The performance of keeping humidity of whitening and moistening skin maintenance frost prepared by embodiment 1-4 is tested.
Performance of keeping humidity is tested：It is tested using keratoderma hydration rate, instrument used is Corneometer CM825,
By measuring the variation of water content of stratum corneum is weighed using the variation of keratoderma capacitance before and after product, so as to evaluate
Moisture-keeping efficacy.Test method：120 female subjects are randomly divided into 4 groups, every group 30, the age：20-30 Sui 10,30-
40 years old 10,40-50 Sui 10, bend side in subject or so forearm and mark 3 × 3cm2The square Experimental Area of size, with a left side
Test zone of the arm as whitening and moistening skin maintenance frost, uniform smearing whitening and moistening skin maintenance frost 0.1g every square centimeter, right arm are corresponding
Symmetrical region for blank control, then test detection with Corneometer CM825 and smear whitening and moistening skin maintenance white 8 hours
The moisture of experiment position afterwards, is repeated 5 times respectively, obtains average value, calculated hydration rate.Hydration rate (%)=(test value-sky
White value)/blank value × 100.
Specific test result is shown in Table 2.Each group comparison result shows P ＜ 0.05, and difference has statistical significance.
Table 2：Performance of keeping humidity test result table
| Hydration rate, % | |
| Embodiment 1 | 77 |
| Embodiment 2 | 73 |
| Embodiment 3 | 76 |
| Embodiment 4 | 82 |
Test case 3
The sun-proof result of whitening and moistening skin maintenance frost prepared by embodiment 1-4 is tested.
Blank quartz board test background curve, then precise 0.2mg/cm are used before test2Sample on 3M adhesive tapes face,
Then with the finger rapid application homogeneous sample for taking latex finger cot.Sample panel after smearing and shady place are spontaneously dried
30min, then using ultraviolet ray transmissivity analyzer, (the SPF-290AS ultraviolet lights that Solarlight companies of the U.S. produce penetrate
Rate analyzer) in measure, you can measure the sun-proof value of UVB, represented with spf value.Spf value is determined according to minimum Erythema Dose
's：The minimum Erythema Doses of SPF=(after sun-proof articles)/minimum Erythema Dose (with before sun-proof articles)；The number of SPF sun protection factor
Value is suitable for everyone, and computational methods are：Assuming that the intensity of ultraviolet light will not change because of the time, one without any sun-proof
If the people of measure skin after 20min in the sun can redden, when he uses SPF15 sunscreen products, expression can extend 15 times
Time, that is, skin just can be by turn to red because of sun burn after 300min.
Specific test result is shown in Table 3.Each group comparison result shows P ＜ 0.05, and difference has statistical significance.
Table 3：Sun-proof result test result table
| Spf value | |
| Embodiment 1 | 43 |
| Embodiment 2 | 38 |
| Embodiment 3 | 41 |
| Embodiment 4 | 47 |
The production method of whitening and moistening skin maintenance frost of the present invention, by being explored to polyphenol surfactant preparation process,
It has carried out its emulsifying dispersivity, and active function is eliminated with efficient hydroxy radical, the whitening and moistening skin maintenance frost of preparation is without appointing
Face and hand are wiped in what side effect, external application, the fine and smooth skin of whitening while can have the unique effects such as moistening skin, anti-aging.
Claims (10)
1. a kind of whitening and moistening skin maintenance frost, which is characterized in that be prepared by the raw material of following weight parts：2-5 parts of glycerine, 1,3-
1-2 parts of butanediol, 1-3 parts of biosurfactant, 1-4 parts of natto extract liquor, 43-53 parts of water, 1-3 parts of Co-Q10, Radix Glycyrrhizae
0.05-0.15 parts of chalcone A, 0.5-1.5 parts of vitamin, 1-2 parts of lanolin, 1-4 parts of ester oil, 0.5-1.5 parts of ceramide,
1-2 parts of crude vegetal.
2. the production method of whitening and moistening skin maintenance frost according to claim 1, which is characterized in that the crude vegetal is mountain
Camellia oil or wheat germ oil or evening primrose oil.
3. the production method of whitening and moistening skin maintenance frost according to claim 1, which is characterized in that the system of the natto extract liquor
Preparation Method is：Natto be crushed into 10-30 mesh sieve, then added in the glycerine water solution of 15-25 times of natto weight, ultrasonic extraction
20-60min is centrifuged, with 200-500 mesh filter-cloth filterings, in the case where temperature is 50-70 DEG C, vacuum degree is 0.01-0.06MPa
Concentration, obtains natto extract liquor.
4. the production method of whitening and moistening skin maintenance frost according to claim 3, which is characterized in that sweet in the glycerine water solution
The mass fraction of oil is 40-60wt%.
5. the production method of whitening and moistening skin maintenance frost according to claim 3, which is characterized in that the ultrasound of the ultrasonic extraction
Wave power is 250-450W, supersonic frequency 25-45kHz.
6. the production method of whitening and moistening skin maintenance frost according to claim 1, which is characterized in that the ester oil is lauroyl flesh
Propylhomoserin isopropyl ester or lauroyl glutamate dioctyldodecyl base ester.
7. the production method of whitening and moistening skin maintenance frost according to claim 1, which is characterized in that the biosurfactant
The dodecyl sugar acidamide surfactant being modified for polyphenol surfactant and/or ethyoxyl.
8. the production method of whitening and moistening skin maintenance frost according to claim 7, which is characterized in that the polyphenol surfactant
It is prepared by following methods：95-105g tea polyphenols, 75-85g hexylamines, 20-30g decanoyl chlorides is taken to add in 180-220mL methanol,
Temperature is 35-55 DEG C and 15-25h is stirred by 60-180r/min of rotating speed, is cooled to 0 DEG C with ice water, adds in 90-110g hydroborations
Sodium stirs 40-90min, with 0.2-1mol/L salt acid for adjusting pH to 1-2, using rotating speed as 30- by 60-180r/min of rotating speed
90r/min is stirred to no Precipitation, is filtered and is collected filter cake, and filter cake ethyl alcohol and water wash 2-4 times respectively, are in temperature
40-50 DEG C, vacuum degree be 1.5-3.5h dry under 100-150Pa, obtain a product；By a product with methanol in mass ratio
It is 1：(3-7) is mixed, in rotating speed under 30-90r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters and collects filter
Cake, filter cake ethyl alcohol and water wash 2-4 times respectively, the dry 2.5- in the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa
5.5h obtains intermediate product；It is 1 in mass ratio by intermediate product, methanol, diethylene glycol diglycidyl glycerin ether：(6-9)：(1-2)
Mixing, the heating in water bath for reaction 20-25h at 70-80 DEG C, then vacuum distillation removal methanol, is 40-50 DEG C, vacuum in temperature
Spend for 5-10h dry under 100-150Pa to get.
9. the production method of whitening and moistening skin maintenance frost according to claim 1, which is characterized in that the vitamin is vitamin
A or vitamin E.
10. according to the production method of any one of the claim 1-9 whitening and moistening skin maintenance frosts, which is characterized in that including with
Lower step：
(1) 1,3-BDO, biosurfactant, natto extract liquor, water are added in water phase pot and is uniformly mixed, heated up
To 65-85 DEG C, water phase material is obtained；
(2) glycerine, Licochalcone A, lanolin, ester oil, ceramide, vitamin, crude vegetal are sequentially added into oil phase
In pot, it is heated to 65-85 DEG C and is uniformly mixed, obtain oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and oil phase material is pumped under homogeneous, homogeneous 3-13 minutes at 65-85 DEG C, then
Heat preservation 15-25 minutes, is eventually adding Co-Q10 and is uniformly mixed to obtain the final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108498412A (en) * | 2018-07-04 | 2018-09-07 | 亿利耐雀生物科技有限公司 | A kind of fat-soluble glabridin compound skin-whitening agent and its application |
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