CN108159365A - It is a kind of to be used to treat Chinese medicine composition of coronary heart disease and myocardial ischemia and preparation method thereof - Google Patents
It is a kind of to be used to treat Chinese medicine composition of coronary heart disease and myocardial ischemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, including endo-medicine and external used medicine, endo-medicine is made of the bulk pharmaceutical chemicals of following parts by weight：30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, 15~45 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae, 15~45 parts of fructus amomi, 15~50 parts of galangal, 20~40 parts of green peel, 20~40 parts of earthworm, 10~30 parts of resina liquidamberis, 15~50 parts of cassia twig, 30~70 parts of American Ginseng, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis.Chinese medicine composition of the present invention has effects that yang-tonic tongmai, regulating qi and dredging collateral, eliminating cold to stop pain, yin-nourishing QI invigorating, suitable for treating deficiency of qi and blood type Patients with Myocardial Ischemia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese traditional medicine composition for being used to treat coronary heart disease and myocardial ischemia
Object and preparation method thereof.
Background technology
Myocardial ischemia belongs to coronary heart disease scope, also known as ischemic heart disease, including being allowed to narrow because of coronary atherosclerosis
Narrow or obstruction or its work(sexually revise the myocardial ischemia disease caused by a spasm.Modern medicine believes that, coronary heart disease, myocardial ischemia,
Angina pectoris is since coronary atherosclerosis leads to luminal stenosis or coronarospasm, myocardium transient ischemic, anoxic institute
It is caused using ictal chest pain or chest discomfort as the clinical syndrome mainly showed.The disease mostly occurs in the people on 40 years old
Group, male are more than women, and are more using brain worker.In recent years, the incidence of coronary heart disease, which has, significantly increases, and seriously endangers people
Health.
Motherland's medicine thinks that coronary heart disease and myocardial ischemia belongs to the model of the diseases such as " obstruction of qi in the chest " of traditional Chinese medicine record, " angina pectoris "
Farmland.The pathogenesis of its disease is that due to worn with age, viscera function is deficient, yin and yang qi and blood disorder, in addition inernal injuries caused by seven emotions, diet
Do not save, the influence of the factors such as cold stimulation, work and rest immoderation, lead to qi depression to blood stasis hypofunction of YANG QI in chest, the turbid interior life of phlegm, make heart vessel blockage stasis and
It causes a disease.Therefore, the pathological state of asthenia in origin and asthenia in superficiality is mainly presented in coronary heart disease.This void then in gas, blood, negative and positive, mark is real to be related generally to
Blood stasis, the stagnation of the circulation of vital energy, phlegm are turbid, tremble with fear pathological products or the factor such as solidifying, burning hot.
Although current Western medicine have it is more resist myocardial ischemia, if taking for a long time, patient generates tolerance so that the treatment of drug
Imitate it is bad, and take for a long time Western medicine, it may appear that the side effects such as dizziness headache, palpitating speed, flushed face and renal toxicity.Therefore,
Finding the good drug of therapeutic effect becomes the emphasis of the area research, and traditional Chinese medicine have in such disease is treated it is huge excellent
Gesture according to the dialectical theory of traditional Chinese medicine, is started with from whole, and adjustment body reaches balance, achievees the purpose that effect a permanent cure.
Invention content
In order to solve the deficiencies in the prior art, the present invention provides a kind of for treating the Chinese medicine group of coronary heart disease and myocardial ischemia
Object and preparation method thereof is closed, the Chinese medicine composition is in terms of coronary heart disease disease treat, with therapeutic effect is notable, toxic side effect is small
The advantages of.
To achieve the above object, first purpose of the invention is to provide a kind of for treating in coronary heart disease and myocardial ischemia
Drug composition, including endo-medicine, the endo-medicine is made of the bulk pharmaceutical chemicals of following parts by weight：
30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, 15~45 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae, 15~45 parts of fructus amomi, height
15~50 parts of galingal, 20~40 parts of green peel, 20~40 parts of earthworm, 10~30 parts of resina liquidamberis, 15~50 parts of cassia twig, American Ginseng 30~
70 parts, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis.
Preferably, the Chinese medicine composition further includes external used medicine, and the external used medicine is the original by following parts by weight
Expect spray made of medicine：
10~15 parts of Rhizoma Chuanxiong, 10~15 parts of peppermint, 5~15 parts of amber, 5~10 parts of borneol, 5~10 parts of muscone.
It is highly preferred that the endo-medicine includes the bulk pharmaceutical chemicals of following parts by weight：35~45 parts of Radix Curcumae, aspongopus 28~
40 parts, 20~30 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae, 20~40 parts of fructus amomi, 15~35 parts of galangal, 20~35 parts of green peel, earthworm
25~35 parts, 15~30 parts of resina liquidamberis, 18~30 parts of cassia twig, 30~45 parts of American Ginseng, 25~50 parts of Schisandra chinensis, Radix Ophiopogonis 20~45
Part.
It is highly preferred that the endo-medicine includes the bulk pharmaceutical chemicals of following parts by weight：35 parts of Radix Curcumae, 28 parts of aspongopus, wingceltis
20 parts fragrant, 30 parts of Radix Salviae Miltiorrhizae, 20 parts of fructus amomi, 15 parts of galangal, 20 parts of green peel, 25 parts of earthworm, 15 parts of resina liquidamberis, 18 parts of cassia twig, west
30 parts of American ginseng, 25 parts of Schisandra chinensis, 20 parts of Radix Ophiopogonis.
It is highly preferred that the endo-medicine includes the bulk pharmaceutical chemicals of following parts by weight：40 parts of Radix Curcumae, 35 parts of aspongopus, wingceltis
25 parts fragrant, 40 parts of Radix Salviae Miltiorrhizae, 30 parts of fructus amomi, 20 parts of galangal, 25 parts of green peel, 30 parts of earthworm, 20 parts of resina liquidamberis, 20 parts of cassia twig, west
35 parts of American ginseng, 35 parts of Schisandra chinensis, 30 parts of Radix Ophiopogonis.
It is highly preferred that the endo-medicine includes the bulk pharmaceutical chemicals of following parts by weight：45 parts of Radix Curcumae, 40 parts of aspongopus, wingceltis
30 parts fragrant, 60 parts of Radix Salviae Miltiorrhizae, 40 parts of fructus amomi, 35 parts of galangal, 35 parts of green peel, 35 parts of earthworm, 30 parts of resina liquidamberis, 30 parts of cassia twig, west
45 parts of American ginseng, 50 parts of Schisandra chinensis, 45 parts of Radix Ophiopogonis.
Second object of the present invention is to provide the preparation of the above-mentioned Chinese medicine composition for being used to treat coronary heart disease and myocardial ischemia
Method includes the following steps：
S1：According to parts by weight weigh 30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, 15~45 parts of santal, Radix Salviae Miltiorrhizae 30~
60 parts, 15~45 parts of fructus amomi, 15~50 parts of galangal, 20~40 parts of green peel, 20~40 parts of earthworm, 10~30 parts of resina liquidamberis, osmanthus
It is 15~50 parts of branch, 30~70 parts of American Ginseng, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis, spare；
S2：By the Radix Curcumae weighed, aspongopus, galangal, cassia twig and resina liquidamberis, mixed after dry, crush, be sieved, obtain
Mixing fine powders；
S3：The fructus amomi weighed, santal and Radix Salviae Miltiorrhizae are mixed, the ethyl alcohol seepage flow for adding in 6~10 times of amounts of total dose of mixing carries
It takes, impregnates 6~12h, collect percolating fluid, ethyl alcohol is recycled in filtration, and concentrated, vacuum drying, crushing obtain dry powder；
S4：The American Ginseng weighed, Schisandra chinensis, Radix Ophiopogonis, green peel and earthworm are mixed again, add in total dose 6~10 of mixing
The water of times amount, decocts extraction 2 times, every time 0.5~2h, filtration merges filtrate twice, thick paste is concentrated under reduced pressure into, will be in S2
Obtained mixing fine powders add in thick paste and mix, dry, are ground into dried cream powder；
S5：By the activity to get Chinese medicine composition after the abundant mixing of dried cream powder obtained in dry powder obtained in S3 and S4
Pharmaceutically acceptable oral drug preparation is conventionally made in ingredient, the active constituent.
Preferably, the pharmaceutical dosage form of the oral drug preparation is tablet, capsule, granule, Disket or pill.
Preferably, in S3, seepage flow extraction concentration of alcohol used is 50~70%.
Compared with prior art, the beneficial effects of the present invention are：
The present invention is under Traditional Chinese medical theory and clinical experience guidance, chooses each bulk pharmaceutical chemicals and its proportioning, and compatibility closes
It manages, is precise and appropriate, meeting " monarch " principle, coronary heart disease of the hitting interpretation of the cause, onset and process of an illness；Wherein with Radix Curcumae, Radix Salviae Miltiorrhizae, earthworm and resina liquidamberis altogether for monarch
Medicine, can be promoting blood circulation and removing blood stasis, and nourishing heart is promoted blood circulation, and the stasis of blood of interiorization internal organs is stagnant, outside can promoting menstruation and declare air guide machine.Minister is with cassia twig, santal, nine perfume
Worm, galangal, green peel, four medicine phases of fructus amomi are matched, and can be strengthened the work(of prescription yang-tonic tongmai, regulating qi and dredging collateral, eliminating cold to stop pain, be added west
American ginseng, Radix Ophiopogonis, Schisandra chinensis are to play the work(of yin-nourishing QI invigorating.Prescription of the present invention is based on traditional Chinese medical theory, with reference to clinical experience
Grope what is summarized, each Chinese traditional medicine composition compatibility in side can generate synergistic effect, so as to effective treatment coronary heart disease,
Myocardial ischemia.Drug of the present invention medicine used embodies giving consideration to both the incidental and fundamental and is used, all medicines share, play altogether yang-tonic tongmai, regulating qi and dredging collateral,
The work(of eliminating cold to stop pain, yin-nourishing QI invigorating.
Further, in order to enhance therapeutic effect, provided by the present invention for treating the Chinese medicine group of coronary heart disease and myocardial ischemia
Object is closed, using the method that outer spray is adjusted in the traditional Chinese medical science, on the one hand can invigorate blood circulation and remove the stasis of blood, it is promoting blood circulation, rouse oneself heart；Another aspect QI invigorating row
Blood, blood circulation depending on qi flow make ecchymosis without going out to hide oneself, and are particularly suitable for treatment deficiency of qi and blood type patients with coronary heart disease, i.e., on modern medicine
Coronary atherosclerosis, and myocardial ischemia, the patient with angina pectoris increased with cholesterol, blood glucose and blood pressure.It is tried in clinic
In testing, the traditional Chinese medicine composition for treating significant effect of present invention treatment myocardial ischemia, total effective rate is up to 95%, and obvious effective rate is up to
76%.
Specific embodiment
In order to which those skilled in the art is enable to more fully understand, technical scheme of the present invention is practiced, with reference to specific
The invention will be further described for embodiment, but should not be construed as the limitation of the present invention.Actual conditions are not specified in Examples below
Experimental method, carried out according to the conventional method of this field and condition.
The present invention provides a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, including endo-medicine and external application
Drug, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, santal
15~45 parts, 30~60 parts of Radix Salviae Miltiorrhizae, 15~45 parts of fructus amomi, 15~50 parts of galangal, 20~40 parts of green peel, 20~40 parts of earthworm,
10~30 parts of resina liquidamberis, 15~50 parts of cassia twig, 30~70 parts of American Ginseng, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis.
The external used medicine is the spray made of the bulk pharmaceutical chemicals of following parts by weight：10~15 parts of Rhizoma Chuanxiong, peppermint 10~
15 parts, 5~15 parts of amber, 5~10 parts of borneol, 5~10 parts of muscone.
Above-mentioned raw materials medicine is respectively provided with the effect of following and effect：
Radix Curcumae：Acrid flavour, hardship, Return liver cold in nature, courage, the heart channel of Hang-Shaoyin.Function promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, and cholagogic moves back
It is yellow.For all cards of qi depression to blood stasis, pyreticosis coma, epilepsy phlegm closes, and spits blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, liver and gallbladder damp-heat jaundice, cholelith
Disease.《Compendium of Materia Medica》：" controlling vim and vigour pain in the chest and abdomen, postpartum lochiostasis affecting heart is intended to extremely, insane "；《Essentials of Materia Medica》：" promoting qi circulation and removing obstruction in the collateral,
Let out blood broken stasis of blood.Cool heart heat, dissipates liver depression, controls married woman's passages through which vital energy circulates and drive in the wrong direction "；Modern pharmacology research：Water decoction can reduce whole blood viscosity, suppression
Platelet aggregation processed, alcohol extract can reduce plasma fibrin content.
Aspongopus：Taste is salty, warm Return liver, spleen, kidney channel.Regulating qi-flowing for relieving pain, warming kidney and enhancing yang.For chest side of body abdominal distention, impotence, waist
Knee crymodynia, frequent micturition.《Compendium of Materia Medica》：" curing mainly gastral cavity diaphragm stagnant gas, deficiency of spleen and stomach, kidney-Yang invigorating "；《Book on Chinese herbal medicine is newly organized》：" aspongopus, in worm
To good person, as ball dissipate with help it is weak most preferably.Decoction should not be entered ".Modern pharmacology research：This product, which has, promotes body new old generation
The effect thanked.
Santal：Acrid flavour, temperature.Returns spleen, stomach, the heart, lung channel.Function promoting qi circulation and relieving pain, eliminating cold to stop pain.For chest and abdomen cold obstruction causing qi stagnation.
《Japan hanako materia medica》：" only pain in the chest and abdomen "；《Essentials of Materia Medica》：" adjusting spleen and lung, sharp chest diaphragm is qi-regulating key medicine ".Modern pharmacology research：
In negative inotropic action, there is antagonism to cardiac arrhythmia caused by Sini Tang, cortex acanthopanacis poisoning.
Radix Salviae Miltiorrhizae：Bitter is slightly cold, the thoughts of returning home, pericardium, Liver Channel, promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, and relieving restlessness is calmed the nerves, and uses
In irregular menstruation, amenorrhoea dysmenorrhoea, postpartum stasis of blood, blood stasis is pained, epigastric pain , lumps in the chest and abdomen, rheumatic Bi syndrome, bruise damage
Wound, sore swollen toxin, pyreticosis agitation coma, vexed insomnia.《Japan hanako materia medica》：Blood-nourishing is fixed stagnant, easing joint movement；Broken place blood is mended new
Green blood；Hemostasis is collapsed under band, and tune married woman's passages through which vital energy circulates is irregular, and blood stasis is vexed.《Book on Chinese herbal medicine is just read》：" for Radix Salviae Miltiorrhizae work(with four objects, energy dissolving stasis is with life
Newly, be apt to treat wind with dissipating bind, it is mild-natured and and walk blood, the power enriched blood is insufficient, and the power of promoting blood circulation is had a surplus, to improve medicine first of blood system ".It is modern
Pharmaceutical research shows：Radix Salviae Miltiorrhizae energy coronary artery dilator, increase coronary blood flow, improve myocardial ischemia, promote myocardial ischemia or
Myocardial infarct size is reduced in the recovery of damage；Hypoxia-bearing capability can be improved, has protective effect to ischemic myocardium；Micro- follow can be improved
Ring promotes velocity of blood flow；Blood vessel can be expanded, is reduced blood pressure.Hemorheological property can be improved, reduce blood viscosity, inhibit blood platelet
Aggregation and coagulation function activate fibrinolytic, to antithrombus formation；Erythrocyte membrane can be protected；Blood fat can be adjusted, inhibits Atherosclerosis
Change the formation of patch.
Fructus amomi：It is pungent, warm.Returns spleen, stomach, kidney channel.Function dampness elimination promoting the circulation of qi, warming middle energizer to stop diarrhea, tocolysis.For damp retention in middle-jiao and spleen
Stomach syndrome of qi stagnation, deficiency-cold in spleen and stomach are vomited and diarrhoea, stagnation of the circulation of vital energy pernicious vomiting and fetal irritability.《Haigoushen》：" main cold air abdominal pain, only rest gas
Dysentery, strain digest trough, warm taste ".《Kaibao Bencao》：" controlling the cold dysentery of consumptive disease, vegetarian diet does not disappear, red white rush down dysentery ".
Galangal：It is pungent, property is hot, returns spleen, stomach.Function eliminating cold to stop pain, warming middle energizer to arrest vomiting.For stomach cold crymodynia, gastrofrigid vomiting.
《Name doctor not rate》：" master produces an unexpected winner, and cold in the stomach is inverse, abdominal pain due to acute vomiting and diarrhea ".《Collected statements on the herbal foundation》：" galangal, dispellieg cold and dampness, the medicine of warm taste
".Modern pharmacology research：Using internal thrombosis method, have to rat oral gavage galangal water extract or volatile oil anti-
The effect of thrombosis.
Green peel：It is bitter, pungent, warm, Return liver, courage, stomach.Function is soothing the liver relieving stagnant Qi, disperse accumulationization are stagnant.For stagnation of QI due to depression of the liver, gastral cavity abdomen pain
Bitterly, lumps in the chest and abdomen, chronic malaria lump in the abdomen.《Bencao Tujing》：" the main stagnation of the circulation of vital energy, lower food break product knot and diaphragm gas ".《Collected statements on the herbal foundation》：It is " broken stagnant
Gas cuts the medicine of hard product, and exorcise evil spirits dissipate-swelling ".
Earthworm：Taste is salty, trembles with fear, Return liver, spleen, bladder warp, clearing away heat and relieving the wind syndrome are relievingd asthma, dredging collateral, diuresis, for high fever infantile convulsion, brothers
Twitch, dyspnea and cough due to lung-heat, joint pain, hemiplegia, thermojunction renal shutdown.《Compendium of Materia Medica》：" cold in nature and downlink, it is cold in nature therefore can solve all
Hot disease, lower profit thus can diuresis, control sufficient disease and degrading the channel》”.Modern pharmacology research shows：Earthworm tincture, dry powder are suspended
Liquid, hot dipping liquid, decoction have slow and lasting antihypertensive effect；Pheretima extract has fibrinolytic and anticoagulation.
Resina liquidamberis：Pungent, slight bitter is put down.Return lung, the spleen channel.Function promoting blood circulation and stopping pain, hemostasis removing toxic substances, myogenic.For arthralgia pain due to rheumatism,
Traumatic injury, blood-head tells nosebleed, scrofula ulcer sore pain.《Compendium of Materia Medica》：" myogenic pain relieving, removing toxic substances ".《Collected statements on the herbal foundation》：" study carefully its taste
Hardship, energy cool blood heat, Xin Ping, the complete carbuncle of energy ".Modern pharmacology research：This product volatile oil has anti thrombotic action.
Cassia twig：It is pungent, sweet, warm.The thoughts of returning home, lung, bladder warp.Function sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.For chill
Flu, cold obstruction causing qi stagnation, phlegm and retained fluid water storage, palpitaition.《Medicine origin》：" going wind wound headache, skin rheumatism is gone in loosing the interspaces of skin and muscles, inducing diaphoresis ".
《Bencao Jingshu》：" real table uncharms ".Modern pharmacology research：Cassia oil has stomach invigorating, alleviates cramps of gastrointestinal tract and diuresis, cardiac stimulant
Effect.
American Ginseng：It is sweet, slight bitter, cool.Return lung, the heart, spleen, kidney channel.Function boosting qi and nourishing yin, clearing heat and promoting fluid.For impairment of both QI and YIN
Card, Lung Qi deficiency and syndrome of deficiency of lung yin.Hinder in pyreticosis deficiency of vital energy Tianjin.《The new compilation of materia medica》：" tonifying lung fall fire, born fluid, relieving restlessness are tired.”《Medicine inner feelings
The record of middle ginseng west》：" qi leel can be subsidized, and can tonifying Qi and blood." modern pharmacology research：This product has anti anoxia, resists myocardial ischemia,
Anti- cardiac muscle oxidation, increases myocardial contractive power, hypoglycemic, hemostasis and antidiuretic activity.
Schisandra chinensis：It is sour, sweet, warm.Return lung, the heart, kidney channel.Function restrains astringent method, nourishing generate fluid, kidney calming.For chronic cough
Void asthma, spontaneous sweating, emission and spermatorrhea, endless diarrhea, injury thirst, palpitation and insomnia dreaminess.《Sheng Nong's herbal classic》：" main QI invigorating, cough
Inverse upper gas, internal lesion caused by overexertion is thin thin, tonifying for the deficiency." modern pharmacology research：This product can increase cellular immune function, have it is anti-oxidant, it is anti-ageing
Old effect.
Radix Ophiopogonis：Sweet, slight bitter is slightly cold.Return stomach, lung, the heart channel of Hang-Shaoyin.Function Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire.For stomach
The deficiency of Yin, Lung-Yin deficiency, the deficiency of the heart-yin.《Sheng Nong's herbal classic》：" main stagnation of vital energy in the chest and abdomen, stomach channels are exhausted.”《Collected statements on the herbal foundation》：" heart clearing, lung moistening it
Medicine, main deficiency of heart-QI, palpitation of palpitating with fear." modern pharmacology research：Experimental animal hypoxia-bearing capability is significantly improved, to myocardial ischemia
There is obvious protective function.
With reference to some specific embodiments, technical scheme of the present invention is further illustrated.
Embodiment 1
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition refers to interior
Medication object, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：The endo-medicine by following parts by weight original
Material medicine is made：Radix Curcumae 35g, aspongopus 28g, santal 20g, Radix Salviae Miltiorrhizae 30g, fructus amomi 20g, galangal 15g, green peel 20g, earthworm 25g,
Resina liquidamberis 15g, cassia twig 18g, American Ginseng 30g, Schisandra chinensis 25g, Radix Ophiopogonis 20g.
The preparation method of above-mentioned endo-medicine includes the following steps：
By Radix Curcumae 35g, aspongopus 28g, galangal 20g, cassia twig 18g and resina liquidamberis 15g, mixed after dry, be ground into 100
Mesh, sieving, obtains mixing fine powders；Then by the fructus amomi 20g weighed, santal 20g, Radix Salviae Miltiorrhizae 30g, 8 times of amounts of medicinal material weight are added in
60% ethyl alcohol is extracted with 60% ethyl alcohol seepage flow, impregnates 8h, collects percolating fluid, is filtered, recycling ethyl alcohol, concentrated, vacuum drying,
It crushes, obtains dry powder；The American Ginseng 30g weighed, Schisandra chinensis 30g, Radix Ophiopogonis 20g, green peel 20g, earthworm 25g are merged again, add in medicine
The water of 8 times of amounts of material weight, decocts extraction 2 times, decocts 1h every time, filters, and merges filtrate twice, thick paste is concentrated under reduced pressure into,
Above-mentioned mixing fine powders addition thick paste is mixed, dry, is ground into dried cream powder；Finally, dry powder obtained above is made with above-mentioned
The abundant mixing of dried cream powder after to get Chinese medicine composition active constituent, the active constituent add in suitable microcrystalline cellulose,
Lactose, granulation is encapsulated, and a hard capsule is made, and specification is every 0.5g.
Embodiment 2
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug and external used medicine, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：The endo-medicine is by following weight
The bulk pharmaceutical chemicals of number are made：Radix Curcumae 35g, aspongopus 28g, santal 20g, Radix Salviae Miltiorrhizae 30g, fructus amomi 20g, galangal 15g, green peel 20g,
Earthworm 25g, resina liquidamberis 15g, cassia twig 18g, American Ginseng 30g, Schisandra chinensis 25g, Radix Ophiopogonis 20g.The external used medicine is by following heavy
Measure spray made of the bulk pharmaceutical chemicals of number：Rhizoma Chuanxiong 10g, peppermint 10g, amber 5g, borneol 5g, muscone 5g.
The preparation method and embodiment 1 of above-mentioned endo-medicine are identical, and the preparation process of external used medicine is specific as follows：
Above-mentioned Rhizoma Chuanxiong, peppermint and amber are ground respectively, soaked, then three is put into distilling flask respectively,
It is heated to reflux, volatile oil volatilizees condensation in extractor with steam, collects each 20ml of volatile oil of three respectively；Later,
The volatile oil of the three of extraction is collected into merging (60ml) and adds in borneol 10g, mixed liquor is added to 25ml by muscone 5g
It in 95% ethyl alcohol, is sufficiently mixed uniformly, is protected from light standing a period of time, filtration obtains clear solution, adds in distilled water constant volume and arrives
120ml is fitted into special spray bottle.
Embodiment 3
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug and external used medicine, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：Radix Curcumae 40g, aspongopus 35g, santal
25g, Radix Salviae Miltiorrhizae 40g, fructus amomi 30g, galangal 20g, green peel 25g, earthworm 30g, resina liquidamberis 20g, cassia twig 20g, American Ginseng 35g, five
Taste 35g, Radix Ophiopogonis 30g.
The preparation process and embodiment 1 of above-mentioned endo-medicine are identical, the difference is that only, the bulk pharmaceutical chemicals of endo-medicine are matched
Fang Butong.And the formula and preparation process and embodiment 2 of external used medicine are identical.
Embodiment 4
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug and external used medicine, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：Radix Curcumae 45g, aspongopus 40g, santal
30g, Radix Salviae Miltiorrhizae 60g, fructus amomi 40g, galangal 35g, green peel 35g, earthworm 35g, resina liquidamberis 30g, cassia twig 30g, American Ginseng 45g, five
Taste 50g, Radix Ophiopogonis 45g.
The preparation process and embodiment 1 of above-mentioned endo-medicine are identical, the difference is that only, the bulk pharmaceutical chemicals of endo-medicine are matched
Fang Butong.And the formula and preparation process and embodiment 2 of external used medicine are identical.
Embodiment 5
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug and external used medicine, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：Radix Curcumae 20g, aspongopus 20g, santal
15g, Radix Salviae Miltiorrhizae 30g, fructus amomi 15g, galangal 15g, green peel 20g, earthworm 20g, resina liquidamberis 10g, cassia twig 15g, American Ginseng 30g, five
Taste 20g, Radix Ophiopogonis 15g.
The preparation process and embodiment 1 of above-mentioned endo-medicine are identical, the difference is that only, the bulk pharmaceutical chemicals of endo-medicine are matched
Fang Butong.And the formula and preparation process and embodiment 2 of external used medicine are identical.
Embodiment 6
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug and external used medicine, the endo-medicine are made of the bulk pharmaceutical chemicals of following parts by weight：Radix Curcumae 60g, aspongopus 50g, santal
45g, Radix Salviae Miltiorrhizae 60g, fructus amomi 45g, galangal 50g, green peel 40g, earthworm 40g, resina liquidamberis 30g, cassia twig 50g, American Ginseng 70g, five
Taste 60g, Radix Ophiopogonis 50g.
The preparation process and embodiment 1 of above-mentioned endo-medicine are identical, the difference is that only, the bulk pharmaceutical chemicals of endo-medicine are matched
Fang Butong.And the formula and preparation process and embodiment 2 of external used medicine are identical.
Embodiment 7
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug, the formula and embodiment 1 of the endo-medicine are identical, the difference is that only preparation process difference, specific as follows：
It in proportion by Radix Curcumae, aspongopus, galangal, cassia twig and resina liquidamberis, is mixed after dry, is ground into 100 mesh, be sieved,
Obtain mixing fine powders；Then by the fructus amomi weighed, santal, Radix Salviae Miltiorrhizae, 50% ethyl alcohol of 10 times of amounts of medicinal material weight is added in, with 50% second
Alcohol seepage flow extracts, and impregnates 12h, collects percolating fluid, and ethyl alcohol is recycled in filtration, and concentrated, vacuum drying crushes, obtains dry powder；Again will
The American Ginseng that weighs, Schisandra chinensis, Radix Ophiopogonis, green peel, earthworm merge, and add in the water of 6 times of amounts of medicinal material weight, decoct extraction 2 times, every time
0.5h is decocted, filtration merges filtrate twice, thick paste is concentrated under reduced pressure into, and above-mentioned mixing fine powders are added in thick paste mixing, are dried
It does, be ground into dried cream powder；Finally, by after dry powder obtained above and the abundant mixing of dried cream powder obtained above to get Chinese medicine group
The active constituent of object is closed, adds in suitable dextrin, sucrose, mixed pelletization is dry, and granule is made, and specification is every bag of 3g.
Embodiment 8
The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease and myocardial ischemia, and the Chinese medicine composition includes for oral administration
Drug, the formula and embodiment 1 of the endo-medicine are identical, the difference is that only preparation process difference, specific as follows：
It in proportion by Radix Curcumae, aspongopus, galangal, cassia twig and resina liquidamberis, is mixed after dry, is ground into 100 mesh, be sieved,
Obtain mixing fine powders；Then by the fructus amomi weighed, santal, Radix Salviae Miltiorrhizae, 70% ethyl alcohol of 6 times of amounts of medicinal material weight is added in, with 70% second
Alcohol seepage flow extracts, and impregnates 6h, collects percolating fluid, and ethyl alcohol is recycled in filtration, and concentrated, vacuum drying crushes, obtains dry powder；It will claim again
The American Ginseng that takes, Schisandra chinensis, Radix Ophiopogonis, green peel, earthworm merge, and add in the water of 10 times of amounts of medicinal material weight, decoct extraction 2 times, every time
Decoction 2h, filtration merge filtrate twice, thick paste are concentrated under reduced pressure into, above-mentioned mixing fine powders addition thick paste is mixed, is dried,
It is ground into dried cream powder；Finally, by after dry powder obtained above and the abundant mixing of dried cream powder obtained above to get Chinese medicine composition
Active constituent, add in appropriate superfine silica gel powder, magnesium stearate, mixing, granulation, compressed tablets.
It can be used alone, and significant in efficacy, and coordinate it should be noted that the embodiment of the present invention 1 provides endo-medicine
Externally applied spray Inhalation in Treating, it is better.Therefore for the following Chinese medicine composition prepared only with embodiment 2, to this hair
Bright effect illustrates.
Further the effect of the present invention is illustrated using clinical test below.
1st, clinical data
1.1st, general information
Accepted outpatient service coronary heart disease patient totally 128 for medical treatment from 2006.Patient is divided into treatment group and control group at random,
Middle treatment group 64, man 37, female 27；Age 46-76 Sui, average (62.73 ± 5.26) year；The course of disease is most 8 months short, longest
10 years, average (5.54 ± 1.53) year.Control group 64, man 34, female 30；Age 48-74 Sui, average (61.89 ±
1.67) year；The course of disease is most 6 months short, longest 12 years, average (5.84 scholar 1.31) year.Two groups of patients have comparable in age, the course of disease
Property (P>0.05).
1.2nd, diagnostic criteria
Reference《New Chinese medicine guideline of clinical investigations》The middle treatment obstruction of qi in the chest (coronary disease and angina pectoris) standard.
1.2.1 tcm diagnosis
Suffocating pain over the chest, very then chest pain radiating to the back；The lighter only feels chest distress, unsmooth breath；ECG examination has ischemic change
Or exercise test is positive.
1.2.2 Standards of Chinese Medical Syndrome Differentiation
The stagnation of the heart blood, stabbing pain over the chest or angina, fixation do not move, and enter Night Watch very, when or palpitation and uneasiness, tongue it is purple dark, deep wiry pulse
It is puckery.
1.2.3 Western medicine diagnostic criteria
1. angina pectoris：It is characterized in the transience chest induced by movement or the myocardium aerobic situation of other increases
Pain is broken out, and after rest or sublingual administration nitroglycerin, pain can often be alleviated rapidly.
2. spontaneous angina pectoris：It is characterized in the increase of episode and myocardium requirementing keto quantity without obvious relation, with the fatigue heart
Angina is compared, and this pain general persistence is longer, and degree is heavier, and is not easy to be alleviated by nitroglycerin.This type has no that enzyme becomes
Change, electrocardiogram often occurs temporary S~T sections and forces down change.
1.2.4 weight grade scale uncomfortable in chest
It is 1. slight：Have a classical angina breaking-out, several minutes of each duration, weekly pain at least break out 2~3 times or every
Day breaking-out 1~3 time, but pain does not weigh, and needs buccal nitroglycerin sometimes；
2. moderate：There is classical angina breaking-out for several times daily, each last for several minutes to l0min, pain is heavier, generally all
Need buccal nitroglycerin；
3. compared with severe：There is multiple classical angina to break out daily, thus influence daily life (such as defecate, wear the clothes), often
The secondary breaking-out duration is longer, need to repeatedly suck nitroglycerin；
4. severe：Panic attacks number and degree compare severe and attach most importance to.
1.2.5 case inclusion criteria
With obstruction of qi in the chest primary symptom, diagnosis is clear and definite, meets Western medicine diagnostic criteria and the Chinese medical discrimination category stagnation of the heart blood, breaks out two weekly
Secondary above Treating Patients of Angina Pectoris.
1.2.6 exclusion criteria
1. coronary heart disease myocardial infarction or other heart diseases are turned out to be on inspection, severe neurological functional disease, climacteric syndrome,
Patient uncomfortable in chest caused by cervical spondylosis.
2. merge moderate more than hypertension, severe cardiopulmonary insufficiency, liver, kidney, hemopoietic system severe primary disease, essence
Refreshing patient.
3. under-18s or women breast-feeding their children, those who are allergic to this drug.
4. not meeting inclusion criteria, not by regulation medication, it can not judge that curative effect or data be not congruent, affect the treatment or pacify
Full property judgement person.
2.1st, therapy
Two groups deactivate all antianginal drugs in 2 weeks before the treatment, and whens angina pectoris attacks can buccal nitroglycerine tablets.2 weeks
Afterwards treatment group take the embodiment of the present invention 2 offer capsule, 2~3 tablets/time, 1~3 time/d.Control group takes orally Tongxinluo medicinal capsule
3 tablets/time, 3 times/d of (production of company of Jinlin Aodong Medicine Industry Groups)；Externally applied spray sucks, and is used cooperatively for daily 2~3 times.The heart during treatment
Interim buccal nitroglycerine tablets, disable other antianginal drugs, 7 days courses for the treatment of, two groups are treated 5 when angina is broken out
Week, while give less salt low fat bland diet.
2.2nd, observation of curative effect
2.2.1 criterion of therapeutical effect
According to《New Chinese medicine guideline of clinical investigations》The middle treatment obstruction of qi in the chest (coronary disease and angina pectoris) standard determination.
(1) symptom criterion of therapeutical effect：
1. it is slight, it is effective：Symptom disappear or mostly disappear.Effectively：Panic attacks number, degree and duration have significantly
Mitigate.In vain：Symptom with treatment before it is essentially identical.
2. moderate, effective：Symptom disappear or mostly disappear.Effectively：Symptom is relieved to the standard of " slight ".In vain：Symptom
With it is essentially identical before treatment.
It is 3. effective compared with severe：Symptom disappears or is relieved to the standard of " slight " substantially.Effectively：Symptom is relieved to " moderate "
Standard.In vain：Symptom with treatment before it is essentially identical.
4. severe, effective：Symptom disappears or is relieved to the standard of " moderate " substantially.Effectively：Symptom is relieved to " compared with severe "
It is below the mark.In vain：Symptom with treatment before it is essentially identical.
(2) ECG curative effect standard：
It is 1. effective：Electrocardiogram restores to " substantially normal " or reaches " normal ECG ".
2. effectively：S~T sections of reduction, with more than rise 0.05mv after treatment, but not up to normal level, mainly leading
Connection negative T wave shoals (up to more than 25%) or T waves become upright from flat, chamber or intraventricular block improver.
It is 3. invalid：Electrocardiogram with treatment before it is essentially identical.
2.2.2 clinical test results are shown in Table 1.
1 clinical test results of table count
Two groups of obvious effective rate curative effects compare in table 1, P<0.05, significant difference shows oral traditional Chinese medicine composition of the present invention
The effect for the treatment of coronary heart disease is better than the therapy of conventional Chinese patent drug.
3rd, safety
After clinical observation result shows that 64 patients for the treatment of group take Chinese medicine composition of the present invention, blood routine, urine are normal
Rule, liver function change without exception, have no adverse effects to renal function, no obvious toxic-side effects, take safe and reliable.To sum up institute
It states, Chinese medicine composition of the present invention has the advantages that patients with coronary heart disease significant in efficacy, toxic side effect is small, and preparation process is simple,
Stablize.This also further illustrates that Chinese medicine composition of the present invention has good market application foreground.
4th, model case
1st, Chen, man, 57 years old, first visit on April 12 in 2010, uncomfortable in chest, shortness of breath, pectoralgia recurrent exerbation 3 years.Present illness history：Suffer from
Person before 3 years because of fatigue after there is precordial fullness pain, it is " coronary heart disease " to go to a doctor in Zhengzhou hospital diagnosis, and rule takes nitric acid fat
Class drug, every exacerbation of symptoms when tired or slightly strenuous exercise, oral nitroglycerin piece can be alleviated, now to ask middle treatment
It treats, therefore goes to a doctor in our hospital's outpatient service.Inscribe disease:Occasionally there are uncomfortable in chest, shortness of breath, pectoralgia, tired postemphasis, shortness of breath is weak, dry, and mouth is not
It is very bitter, spontaneous perspiration, foul wind, receive dormancy can, stool is dry, and urine is still adjusted.Blood pressure 130/80mmHg after depressor is taken, denies that diabetes etc. are slow
History of venereal disease；Deny drug and food hypersenstivity history.Simultaneous to see pale tongue, tongue is thin, thready and hesitant pulse.The deficiency of vital energy deficiency of blood is diagnosed as, heart arteries and veins disharmony type belongs to
In deficiency of qi and blood type coronary heart disease.The oral medicament composition preparation of the embodiment of the present invention 2 for oral administration, 3 times a day, 2 tablets each time, external application
Spray sucks, and twice daily, even served two weeks, after patient tells medication, occasionally there is uncomfortable in chest, without pain, there is strength earlier above, mouth is not done, and is received
Sleep can, defecate top dry-up, it is small.Tongue nature is slightly red, and tongue is thin white, small and wiry pulse, earlier above effectively.Continue to take half a year, electrocardiogram is earlier above
Restore normal point position.
2nd, hair, female, 46 years old, railway crew, patient broke out in starting pectoralgia occur two months ago, and pain is difficult
Bear, be in a twinkle, mostly break out after labour, activity, during episode, sublingual administration nitroglycerine tablets can terminate pain.It is main
It tells：Recently breaking-out is frequent, and the pectoralgia duration is long, and there is tenderness sense in anterior pectorial region, draws left shoulder bitterly, sees its tongue picture, purplish tongue, arteries and veins
It is heavy and short.Electrocardiogram is prompted：ST sections move down, and T waves are inverted, complete right bundle branch block.It is stagnant to be diagnosed as the blood stasis of blood, heart-yang
Depressed, heart arteries and veins is not smooth.Card belongs to qi deficiency to blood stasis, heart vessel blockage stasis type coronary heart disease.The oral medicament composition of the embodiment of the present invention 2 for oral administration
Preparation, 3 times a day, 2 tablets each time, externally applied spray sucking, 3 times a day, two examine:After two weeks, subjective symptoms improves earlier above for clothes medicine-feeding,
Original side is constant, continuously takes 7 months, and patient symptom is obviously improved, and continues to take medicine-feeding to consolidate curative effect.Check electrocardio diagram：
ST sections, T waves have restored normal, visit half a year, all are all right.
3rd, certain is shut out, man, 59 years old, sanitationman, first visit on November 18 in 2006.Patient was in 2006, whenever work is tight
Or fatigue there is pareordia and feel oppressed pain, last every time several minutes, rest or buccal suxiao jiuxin pills can be alleviated, nearly two
Because being busy with one's work over a month, above-mentioned symptom aggravates, and breaking-out is frequent.It sweats all over during breaking-out, it is difficult to endure, rest, buccal nitric acid
Glycerine cannot all be alleviated, and send rescue to hospital then.Electrocardiogram is reported:Front V3-V5 Lead ST segment levels move down 1.5mv, and T waves fall
It puts, prompts chronic coronary insufficiency, clinical diagnosis " coronary disease and angina pectoris (instability mode) ".Hand held object is sent out since onset
It trembles, shortness of breath and fatigue, dry, defecates micro- dry, it is not good enough to take Western medicine curative effect.Previously there is hypertension history.Indagation:Blood pressure 150/
90mmHg (has taken depressor), spirit can, shortness of breath, from sweating, body temperature is relatively low, and pale tongue is dark, and purple lips is red, 85 beats/min of heart rate,
Rule is neat, and first heart sound is low, audible and fourth heart sound.Double lower limb pneumonedema.Thin lingual fur, small and wiry pulse is puckery, it is heavy take it is powerless.It is dialectical:The deficiency of vital energy
It is depressed, the stagnation of the heart blood.Therapy:Blood-enrich, nourishing heart are promoted blood circulation.The oral medicament composition preparation of the embodiment of the present invention 2 for oral administration, often
Day 2 times, 3 tablets each time, externally applied spray sucking, 2 times a day, spiritual amelioration, shortness of breath uncomfortable in chest mitigate after two weeks for medication, and seizure frequency subtracts
It is few.Original side's plus-minus treatment 4 months is kept, above-mentioned symptom complete incidence graph repeatedly checks electrocardiogram, and ST sections are restored normal, and T waves are by being inverted
Gradually switch to uprightly, daily routines are unrestricted.
4th, Sun, man, 65 years old, retired professor.First visit on the 18th in 07 month in 2008.Patient's repeated relapsing pareordia angina 7
Year, it aggravates more than 2 months.Recurrent exerbation pareordia drum is bitterly, after fatigue more so, buccal sometimes in sense of feeling oppressed since two thousand seven by patient
Suxiao jiuxin pills, nifepine can be alleviated.It is frequent to carry out angina pectoris attacks nearly January, with shortness of breath and fatigue, spontaneous perspiration fear of wind, mouth is light to be received less, greatly
Just it is micro- dry, it takes western medicine result difference and seeks medical advice.Doctor trained in Western medicine is diagnosed as coronary disease and angina pectoris (instability mode).Indagation:Blood pressure 17.3/
12.0kPa, spiritual poor, 120 beats/min of shortness of breath heart rate, left side body temperature are less than right side, and sweat is more, and simultaneous to see light purplish tongue, tongue is thin white, arteries and veins
It is heavy thin puckery.It is diagnosed as qi deficiency to blood stasis numbness resistance heart arteries and veins, hypofunction of YANG QI in chest.Belong to asthenia of qi and blood stasis of blood type myocardial ischemia.The present invention for oral administration is implemented
The oral medicament composition of example 2,3 times a day, 1 tablet each time, cooperation externally applied spray, Inhalation in Treating, four times per day.After medication 2 weeks
Conscious spirit amelioration, pain uncomfortable in chest, shortness of breath improve, defence's plus-minus treatment half a year, above-mentioned symptom direct release, and ST sections of electrocardiogram check is extensive
It is multiple normal.Continue to take to consolidate curative effect.Outgoing work is more than half a year, though there is tired also non-re-pull.
It should be noted that involved in claims of the present invention during numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, since the step method of use is identical with embodiment,
It repeats in order to prevent, description of the invention preferred embodiment, although preferred embodiments of the present invention have been described, but ability
Technical staff in domain once knows basic creative concept, then additional changes and modifications may be made to these embodiments.
So appended claims are intended to be construed to include preferred embodiment and fall into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (9)
1. a kind of Chinese medicine composition for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that described for oral administration including endo-medicine
Drug is made of the bulk pharmaceutical chemicals of following parts by weight：
30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, 15~45 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae, 15~45 parts of fructus amomi, galangal
15~50 parts, 20~40 parts of green peel, 20~40 parts of earthworm, 10~30 parts of resina liquidamberis, 15~50 parts of cassia twig, American Ginseng 30~70
Part, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis.
2. the Chinese medicine composition according to claim 1 for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that further include
External used medicine, the external used medicine are the spray made of the bulk pharmaceutical chemicals of following parts by weight：
10~15 parts of Rhizoma Chuanxiong, 10~15 parts of peppermint, 5~15 parts of amber, 5~10 parts of borneol, 5~10 parts of muscone.
3. the Chinese medicine composition according to claim 1 or 2 for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that institute
State the bulk pharmaceutical chemicals that endo-medicine includes following parts by weight：
35~45 parts of Radix Curcumae, 28~40 parts of aspongopus, 20~30 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae, 20~40 parts of fructus amomi, galangal
15~35 parts, 20~35 parts of green peel, 25~35 parts of earthworm, 15~30 parts of resina liquidamberis, 18~30 parts of cassia twig, American Ginseng 30~45
Part, 25~50 parts of Schisandra chinensis, 20~45 parts of Radix Ophiopogonis.
4. the Chinese medicine composition according to claim 3 for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that in described
Medication object includes the bulk pharmaceutical chemicals of following parts by weight：
35 parts of Radix Curcumae, 28 parts of aspongopus, 20 parts of santal, 30 parts of Radix Salviae Miltiorrhizae, 20 parts of fructus amomi, 15 parts of galangal, 20 parts of green peel, earthworm 25
Part, 15 parts of resina liquidamberis, 18 parts of cassia twig, 30 parts of American Ginseng, 25 parts of Schisandra chinensis, 20 parts of Radix Ophiopogonis.
5. the Chinese medicine composition according to claim 3 for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that in described
Medication object includes the bulk pharmaceutical chemicals of following parts by weight：
40 parts of Radix Curcumae, 35 parts of aspongopus, 25 parts of santal, 40 parts of Radix Salviae Miltiorrhizae, 30 parts of fructus amomi, 20 parts of galangal, 25 parts of green peel, earthworm 30
Part, 20 parts of resina liquidamberis, 20 parts of cassia twig, 35 parts of American Ginseng, 35 parts of Schisandra chinensis, 30 parts of Radix Ophiopogonis.
6. the Chinese medicine composition according to claim 3 for being used to treat coronary heart disease and myocardial ischemia, which is characterized in that in described
Medication object includes the bulk pharmaceutical chemicals of following parts by weight：
45 parts of Radix Curcumae, 40 parts of aspongopus, 30 parts of santal, 60 parts of Radix Salviae Miltiorrhizae, 40 parts of fructus amomi, 35 parts of galangal, 35 parts of green peel, earthworm 35
Part, 30 parts of resina liquidamberis, 30 parts of cassia twig, 45 parts of American Ginseng, 50 parts of Schisandra chinensis, 45 parts of Radix Ophiopogonis.
7. the preparation method of the Chinese medicine composition according to claim 1 for being used to treat coronary heart disease and myocardial ischemia, feature
It is, includes the following steps：
S1：According to parts by weight weigh 30~60 parts of Radix Curcumae, 20~50 parts of aspongopus, 15~45 parts of santal, 30~60 parts of Radix Salviae Miltiorrhizae,
15~45 parts of fructus amomi, 15~50 parts of galangal, 20~40 parts of green peel, 20~40 parts of earthworm, 10~30 parts of resina liquidamberis, cassia twig 15~
50 parts, 30~70 parts of American Ginseng, 20~60 parts of Schisandra chinensis, 15~50 parts of Radix Ophiopogonis, it is spare；
S2：By the Radix Curcumae weighed, aspongopus, galangal, cassia twig and resina liquidamberis, mixed after dry, crush, be sieved, mixed
Fine powder；
S3：The fructus amomi weighed, santal and Radix Salviae Miltiorrhizae are mixed, add in the ethyl alcohol seepage flow extraction of 6~10 times of amounts of total dose of mixing, leaching
6~12h is steeped, collects percolating fluid, ethyl alcohol is recycled in filtration, and concentrated, vacuum drying, crushing obtain dry powder；
S4：The American Ginseng weighed, Schisandra chinensis, Radix Ophiopogonis, green peel and earthworm are mixed again, add in 6~10 times of amounts of total dose of mixing
Water, decoct extraction 2 times, every time 0.5~2h, filtration merges filtrate twice, thick paste is concentrated under reduced pressure into, will be obtained in S2
Mixing fine powders add in thick paste mix, dry, be ground into dried cream powder；
S5：By the active constituent to get Chinese medicine composition after the abundant mixing of dried cream powder obtained in dry powder obtained in S3 and S4,
Pharmaceutically acceptable oral drug preparation is conventionally made in the active constituent.
8. the preparation method of the Chinese medicine composition according to claim 7 for being used to treat coronary heart disease and myocardial ischemia, feature
It is, the pharmaceutical dosage form of the oral drug preparation is tablet, capsule, granule, Disket or pill.
9. the preparation method of the Chinese medicine composition according to claim 7 for being used to treat coronary heart disease and myocardial ischemia, feature
It is, in S3, seepage flow extraction concentration of alcohol used is 50~70%.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105561135A (en) * | 2014-10-08 | 2016-05-11 | 李晓静 | Coronary heart disease treating codonopsis pilosula-ophiopogon japonicus-panax notoginseng traditional Chinese medicine medicinal instant granules |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561135A (en) * | 2014-10-08 | 2016-05-11 | 李晓静 | Coronary heart disease treating codonopsis pilosula-ophiopogon japonicus-panax notoginseng traditional Chinese medicine medicinal instant granules |
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