CN108159274A - Application of the bletilla in prophylactic treatment hemorrhoid - Google Patents
Application of the bletilla in prophylactic treatment hemorrhoid Download PDFInfo
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- CN108159274A CN108159274A CN201711467997.1A CN201711467997A CN108159274A CN 108159274 A CN108159274 A CN 108159274A CN 201711467997 A CN201711467997 A CN 201711467997A CN 108159274 A CN108159274 A CN 108159274A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention relates to a kind of bletilla functional products of prophylactic treatment hemorrhoid and preparation method thereof, take 5~25 parts of 20~80 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, 3~30 parts of eleostearic acid, 3~10 parts of dihydromyricetin and chrysanthemum water extract, add in suitable water, after mechanical agitation mixing, vacuum drying makes its water content be reduced to 30% hereinafter, being saved backup using vacuum packaging.Addition eleostearic acid contributes to dissolving and the stabilization of dihydromyricetin, also allows for making product formation emulsifiable paste shape, is conducive to patient's use.Addition Pseudobulbus Bletillae (Rhizoma Bletillae) extract makes product have hemostasis and skin-active effect, inhibits the growth of large intestine harmful microorganism after being cooperateed with chrysanthemum extract and dihydromyricetin, improves effect of ejecting poison.
Description
Technical field
Bletilla functional product the present invention relates to prophylactic treatment hemorrhoid and preparation method thereof, and in particular to a kind of addition
Application of the functional product of bletilla in prophylactic treatment hemorrhoid belongs to the technical field of natural drug application.
Background technology
It bletilla also known as gives free of charge, Lian Jicao, purple blue root, is orchid family bletilla category herbaceos perennial, bletilla pseudobulb is normal
With Chinese medicine, hemostasis convergence, detumescence and promoting granulation effect are good.It is used as medicine and for oral administration cure mainly hemoptysis of pulmonary tuberculosis, bronchiectasis hemoptysis, gastric ulcer and spit
Blood, hematuria, the diseases such as have blood in stool；Traumatic hemorrhage, burn and scald, rhagadia manus et pedis etc. are controlled in external application.
Bletilla haemostatic effect is definitely reliable, related with contained a large amount of bletilla glue.The physicochemical property and Arabic gum of bletilla glue,
Tragacanth is similar, but stickiness is special.Bletilla glue film forming has stronger adhesion strength, spreads on the blutpunkte or face of animal, can be at once
It is merged with the surface of a wound and is difficult to remove, and be only dissolving on one side for contact wound, thus can stopped blooding rapidly and prevent from infecting.
It is demonstrated experimentally that Pseudobulbus Bletillae (Rhizoma Bletillae) extract has the function of to shorten the clotting time, inhibits human body that can quickly form artificial cellulose dissolution
Thrombus has good therapeutic effect to trauma hemostasis or visceral hemorrhage clinical treatment, safe and without any side effects.
Bletilla glue belongs to the smaller natural polymer of molecular weight, but no antigen, without pyrogenicity, with animal body tissue
It is preferably compatible, and can be absorbed by slowly degradation.Medical personal repairs disrupted tissue using the excellent performance of bletilla glue,
Making certain surgical disease treatments that need not perform the operation can also solve.For example, Zhu Zhian etc. is by bletilla glue and decalcification Jing Guo specially treated
Plyability biology skull material is made in bone, for repair skull defect, in compatibility, plasticity, free constancy and disinfection
Very satisfied effect is obtained in terms of hardenability.To the phlegm pipe case after certain perforated ulcers, anastomosis, with oral bletilla glue
Or bletilla treated powder, there is preferable filling repair.
Bletilla gumminess excellent as food, the thickener of cosmetic field, suspending agent, moisturizer and can help breast
Agent, be alternatively arranged as good excipient, powder, film, gelling agent host material.Bletilla glue, bletilla alkaloid, Yi Jibai
And other active components, inhibit tumor cell proliferation, delay skin aging and thickening, suspension, moisturizing, help emulsification and tax
Type etc. has extensive market prospects.The especially Rhizoma Bletillae of different molecular weight is opened in prophylactic treatment hemorrhoid new drug
Originating party face has extremely vast market prospect.
Eleostearic acid is white crystal, and there are three conjugated double bonds in molecule.There are many cis-trans-isomer, wherein α-paulownia (oil) acid with
β-paulownia (oil) acid is mostly important.α-paulownia (oil) acid, 48~49 DEG C of fusing point.It is not soluble in water, it is dissolved in ethyl alcohol and ether.In daylight, sky
It is unstable in gas etc..Easily aoxidized.It is changed into β-paulownia (oil) acid by the effect of daylight, sulphur, selenium, sulfide, selenides etc..Its
Glyceride is the main component of tung oil.β-paulownia (oil) acid, 71 DEG C of fusing point.It is not soluble in water, it is more difficult to be dissolved in ethyl alcohol and ether.It is relatively steady
It is fixed.It is not easy to be aoxidized.
Dihydromyricetin is the extract of vitis spp vine tea, is the main active flavonoid in vine tea
Object, such substance, which has, removes a variety of peculiar effects such as free radical, anti-oxidant, antithrombotic, antitumor, anti-inflammatory；And dihydromyricetin
Element is a kind of more special flavone compound, release alcoholism, prevention alcoholic liver, fatty liver, inhibit liver cell deteriorate,
It reduces the incidence of liver cancer, anti-hypertension, the formation for inhibiting extracorporeal platelet aggregation and internal thrombus, reduce blood fat and blood glucose water
Flat, improving SOD activity and liver protecting etc. has special efficacy.
Chrysanthemum is perennial herb, chrysanthemum aqueous extract anti-bacteria and anti-virus, heat clearing and inflammation relieving, anti-oxidant prevention skin aging.
Meadow sweet essence triple effect disobeys orders ingredient, inhibit 5a- reductases it is active convergence pore reduce grease wild chrysanthemum containing can be widely used for
Treat the diseases such as furunculosis carbuncle swells, abscess of throat, wind-fire red eye, dizziness of having a headache.There is good antihypertensive effect again simultaneously, available for height
The auxiliary treatment of blood pressure diseases.
Invention content
Dihydromyricetin can effectively inhibit the growth of microorganism, and bletilla polysaccharide can play anastalsis and play slow
Effect is released, eleostearic acid can lubricate enteron aisle.
Therefore, first purpose of the invention is to provide a kind of bletilla functional product of prophylactic treatment hemorrhoid：Bletilla is taken to carry
5~25 parts of 20~80 parts of object, 3~30 parts of eleostearic acid, 3~10 parts of dihydromyricetin and chrysanthemum water extract are taken, adds in suitable water,
After mechanical agitation mixing, vacuum drying makes its water content be reduced to 30% hereinafter, being saved backup using vacuum packaging.
In a specific embodiment, wherein each material composition is formed with following parts by weight：Take Pseudobulbus Bletillae (Rhizoma Bletillae) extract 20~
5~15 parts of 80 parts, 5~20 parts of eleostearic acid, 5~10 parts of dihydromyricetin and chrysanthemum water extract, add in suitable water, mechanical agitation
After mixing, vacuum drying makes its water content be reduced to 30% hereinafter, being saved backup using vacuum packaging.
In another embodiment, wherein each material composition is formed with following parts by weight：Take Pseudobulbus Bletillae (Rhizoma Bletillae) extract 60
Part, 5 parts of eleostearic acid, 5 parts of dihydromyricetin and 10 parts of chrysanthemum water extract, add in suitable water, and after mechanical agitation mixing, vacuum is done
It is dry that its water content is made to be reduced to 30% hereinafter, being saved backup using vacuum packaging.
The dihydromyricetin, eleostearic acid are directly bought from market, it is desirable that dihydromyricetin cellulose content >=98.8%, eleostearic acid content
>=98.8%.
Second purpose of the invention is to provide a kind of preparation method of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, and it is produced for bletilla functionality
In product, step includes：
(1) dry bletilla is crushed, after adding in 10~30min of petroleum ether and stirring, 1~3 small layered is stood, is repeated once,
Obtain the upper solution containing petroleum ether and precipitation I.
(2) a certain amount of water is added in into precipitation I, amylase is added to final concentration 100U/L, in 25~40 DEG C of stirrings
After keeping the temperature 2~10h, 75~90 DEG C are again heated to, after keeping the temperature 30~60min, 6000rpm~9000rpm centrifuges 10~20min,
Supernatant is obtained, goes to precipitate.
(3) supernatant is concentrated under reduced pressure into certain volume at 50~65 DEG C, adds 95% ethyl alcohol to final concentration and reach
More than 75%, alcohol precipitation 10-20h are filtered, and obtain filter residue and dry as precipitation II.
(4) upper solution containing petroleum ether at 50~65 DEG C is concentrated under reduced pressure into dry, obtains extract.
(5) extract and precipitation II are pressed 0~5：10 are mixed, as Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
In one embodiment, petroleum ether described in step (1) is the petroleum ether for using 60~90 DEG C of boiling range specifications,
Volume L is 2~6 with bletilla weight kg ratios：1.
In one embodiment, volume L and bletilla weight the kg ratio that water is added in described in step (2) are 2~4：1.
In one embodiment, certain volume described in step (3) refers to the 1/20-1/50 of original volume.
In one embodiment, it is filtered described in step (3)：Membrane aperture is that 0.22 μm of ceramic membrane filter is primary.
Third purpose of the present invention is to provide a kind of preparation method of chrysanthemum water extract, and it is functional for bletilla
In product, step includes：
(a) chrysanthemum is taken to add in the water of 3~10 times of weight, is heated with stirring to 70~85 DEG C, after keeping the temperature 20~80min, filtering
Filtrate is obtained, goes to precipitate.
(b) filtrate is placed in vacuum drier room temperature and carries out slowly dry dried object, as chrysanthemum water extract.
Above-mentioned bletilla functional product or bletilla polysaccharide can be directly used in the hemostasis of various patient wounds, skin healing
It waits in materials, also can be directly used for the application of water-keeping material etc. in cosmetics, can be used for inhibiting various pathogens etc.
In medical material.
Technique effect
1st, addition eleostearic acid contributes to dissolving and the stabilization of dihydromyricetin, also allows for making product formation emulsifiable paste shape, be conducive to
Patient uses.
2nd, addition Pseudobulbus Bletillae (Rhizoma Bletillae) extract makes product have hemostasis and skin-active effect, is cooperateed with chrysanthemum extract and dihydromyricetin
Inhibit the growth of large intestine harmful microorganism afterwards, improve effect of ejecting poison.
3rd, it is special using bletilla adhesivity, chrysanthemum extract and dihydromyricetin is made to be stopped for a long time in part, is strengthened
The repair of chrysanthemum extract and dihydromyricetin to hemorrhoid.
Specific embodiment
In the following, the present invention will be further detailed with embodiment, but it is not limited to any of these embodiments
A or similar example.
Embodiment 1：The preparation method of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
Dry bletilla 100kg is crushed, after being directly added into the petroleum ether and stirring 20min of 200L, 1h layering removals is stood and contains
The upper solution of petroleum ether, is repeated once, and obtains precipitation I；400L water is added in into precipitation I, adds amylase (market purchase)
To final concentration 100U/L, after 35 DEG C of stirring heat preservation 6h, 85 DEG C are again heated to, after keeping the temperature 60min, 7000rpm centrifugation 20min,
Supernatant is obtained, goes to precipitate.Supernatant at 50-65 DEG C is concentrated under reduced pressure into the 1/25 of original volume, adds 95% ethyl alcohol extremely
Final concentration reaches more than 75%, alcohol precipitation 10-20h, and it is primary that filter residue precipitates II to carry out 0.22 μm of ceramic membrane filter.Contain stone
Oily ether upper solution is concentrated under reduced pressure into dry at 50~65 DEG C, obtains extract.50g extracts and 500g precipitations II are mixed
It closes, as Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Embodiment 2：The preparation of bletilla functional product
Pseudobulbus Bletillae (Rhizoma Bletillae) extract 120g and chrysanthemum water extract 20g are taken, 100mL water is added in and is stirred to form paste；Again to it
Middle addition 10g eleostearic acids and 10g dihydromyricetins, be stirred it is uniformly mixed, vacuum drying make its water content be reduced to 30% with
Under, it is saved backup using vacuum packaging.
Embodiment 3：The preparation of bletilla functional product
Pseudobulbus Bletillae (Rhizoma Bletillae) extract 130g and chrysanthemum water extract 20g are taken, 100mL water is added in and is stirred to form paste；Again to it
Middle addition 10g eleostearic acids and 8g dihydromyricetins, are stirred after mixing, vacuum drying make its water content be reduced to 30% with
Under, it is saved backup using vacuum packaging.
Embodiment 4：Use the therapeutic effect of the product
Suggested use and dosage：After first being cleaned during use, its product is directly attached to hemorrhoid position, twice a day.
Clinic trial observations：Test of cure 50 altogether, wherein man 35, female 15.Diagnostic criteria：Before according to experiment
Patient is diagnostic criteria through doctor's clinical diagnosis result in hospital surgery, and hemorrhoid are apparent, with bleeding.Therapy：Patient is first
Hemorrhoid position is cleaned, its product is directly attached to hemorrhoid position, twice a day, most Low doses 1 month, the longest course for the treatment of 3 months.It treats
Criterion is accurate：After external application medicament of the present invention, blood is not healing for hemorrhoid disappearance；Hemorrhoid reduce, not bleeding be it is effective, nothing substantially change for
(poor) in vain.
Interpretation of result：Experiment 50 in total, male 35, women 15, through external application product of the present invention, most Low doses 1
Month, the longest course for the treatment of 3 months, total effective rate 95%, cure rate 84%, invalid 5%.
Claims (10)
1. the present invention provides a kind of bletilla functional product of prophylactic treatment hemorrhoid：Take 20~80 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, eleostearic acid 3~
5~25 parts of 30 parts, 3~10 parts of dihydromyricetin and chrysanthemum water extract, add in suitable water, after mechanical agitation mixing, vacuum
It is dry that its water content is made to be reduced to 30% hereinafter, being saved backup using vacuum packaging.
2. the bletilla functional product of the prophylactic treatment hemorrhoid of claim 1：Take 20~80 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, eleostearic acid 5
5~15 parts of~20 parts, 5~10 parts of dihydromyricetin and chrysanthemum water extract, add in suitable water, after mechanical agitation mixing, very
Sky is dry to make its water content be reduced to 30% hereinafter, being saved backup using vacuum packaging.
3. the bletilla functional product of the prophylactic treatment hemorrhoid of claim 1：Take 60 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, 5 parts of eleostearic acid, two
10 parts of 5 parts of hydrogen myricetin and chrysanthemum water extract, add in suitable water, and after mechanical agitation mixing, vacuum drying makes its water content
30% is reduced to hereinafter, being saved backup using vacuum packaging.
4. a kind of preparation method of Pseudobulbus Bletillae (Rhizoma Bletillae) extract of claim 1-3, and it is used in bletilla functional product, step packet
It includes：
(1) dry bletilla is crushed, after adding in 10~30min of petroleum ether and stirring, 1~3 small layered is stood, is repeated once, must contain
There are the upper solution of petroleum ether and precipitation I；
(2) a certain amount of water is added in into precipitation I, amylase is added to final concentration 100U/L, in 25~40 DEG C of stirring heat preservations 2
After~10h, 75~90 DEG C are again heated to, after keeping the temperature 30~60min, 6000rpm~9000rpm centrifuges 10~20min, obtains supernatant
Liquid goes to precipitate；
(3) supernatant is concentrated under reduced pressure into certain volume at 50~65 DEG C, adds 95% ethyl alcohol to final concentration and reach 75%
More than, alcohol precipitation 10-20h is filtered, and obtains filter residue and dry as precipitation II；
(4) upper solution containing petroleum ether at 50~65 DEG C is concentrated under reduced pressure into dry, obtains extract；
(5) extract and precipitation II are pressed 0~5：10 are mixed, as Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
The method of claim 4, wherein step 5. (1) described petroleum ether is using the petroleum ether of 60~90 DEG C of boiling range specifications,
Volume L is 2~6 with bletilla weight kg ratios：1.
6. the method for claim 4, wherein step (2) volume L and bletilla weight the kg ratio for adding in water are 2~4：1.
The method of claim 4, wherein step 7. (3) described certain volume refers to the 1/20-1/50 of original volume.
The method of claim 4, wherein step 8. (3) described filtering：Membrane aperture is that 0.22 μm of ceramic membrane filter is primary.
9. the preparation method of the chrysanthemum water extract of claims 1 to 3, and it is used in bletilla functional product, step packet
It includes：
(a) chrysanthemum is taken to add in the water of 3~10 times of weight, is heated with stirring to 70~85 DEG C, after keeping the temperature 20~80min, filters to obtain filter
Liquid goes to precipitate；
(b) filtrate is placed in vacuum drier room temperature and carries out slowly dry dried object, as chrysanthemum water extract.
10. the bletilla functional product or bletilla polysaccharide of claim 1~9 are directly used in the hemostasis of various patient wounds, skin
In the materials such as healing, the application of water-keeping material etc. in cosmetics is also can be directly used for, can be used for inhibiting various cause of diseases
In the medical materials such as bacterium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711467997.1A CN108159274A (en) | 2017-12-29 | 2017-12-29 | Application of the bletilla in prophylactic treatment hemorrhoid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711467997.1A CN108159274A (en) | 2017-12-29 | 2017-12-29 | Application of the bletilla in prophylactic treatment hemorrhoid |
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| CN201711467997.1A Pending CN108159274A (en) | 2017-12-29 | 2017-12-29 | Application of the bletilla in prophylactic treatment hemorrhoid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109876089A (en) * | 2019-04-15 | 2019-06-14 | 山东御华景宸生态农业发展有限公司 | A kind of Suppository for treatment of pile and preparation method thereof containing emperor chrysanthemum |
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