CN113288953A

CN113288953A - A preparation for treating burn and scald, and its preparation method

Info

Publication number: CN113288953A
Application number: CN202110698023.4A
Authority: CN
Inventors: 郭丙锋
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-23
Filing date: 2021-06-23
Publication date: 2021-08-24

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and discloses a preparation for treating burns and scalds and a preparation method thereof. The oil preparation is used as a base and is compatible with raw materials for clearing away heat and toxic materials, relieving pain and diminishing inflammation, promoting blood circulation and removing blood stasis, and removing necrotic tissue and promoting granulation, so that the effects of moistening, quickly relieving pain and no secondary wound injury are achieved. It can be used for treating burn, scald, hemorrhoid, and chilblain. Does not need skin grafting or limb amputation, prevents infection, resists infection, treats infection, is safe and does not leave scars. The oil gun promotes the active ingredients of the medicinal materials to be fully dispersed into the oil agent, and the slightly cold characteristic of part of the raw materials is well removed. The processing temperature and the processing time are convenient for prolonging the processing time under the precondition that each Chinese herbal medicine has the function, ensuring that the effective components of each medicinal material can penetrate into the oil agent to the maximum extent and ensuring the high-efficiency treatment of the finished product. Adding the sclerosant and borneol for further healing sore and promoting granulation and clearing heat and relieving pain, and the finished product is paste and is beneficial to transportation and storage. The processed materials are brown, and have hemostatic and toxic materials clearing away effects.

Description

A preparation for treating burn and scald, and its preparation method

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a preparation for treating burns and scalds and a preparation method thereof.

Background

Burns and scalds are injuries caused by external factors such as boiling water (oil), fire, light, radiation or chemical substances, including skin mucosa injuries, serious injuries to subcutaneous tissues can occur, and the burns and scalds are one of the most common and extremely complex trauma diseases which occur in battlefields, fire fighting, mines, factories and various natural disasters and daily work and life. If not properly handled, adverse consequences can result.

The severity of burn and scald is mainly judged according to the position, area and depth of the burn and scald, and generally divided into three degrees according to the depth of the burn and scald:

first-degree burn and scald: only the epidermis layer is injured, and the injured skin is reddened and swollen, has strong pain feeling and does not have blisters;

second degree burn and scald: damage to the dermis, local red swelling, fever, severe pain and obvious blisters;

three-degree burn and scald: the whole skin including subcutaneous fat, bone and muscle are damaged, the skin is scorched and necrotic, and the pain is not severe because nerves are damaged.

At present, a lot of medicines for treating burns and scalds are available, one of the medicines and treatment measures mainly used in western medicine, and the western medicine treatment is to clean (namely debridement) the wound surface, treat and disinfect necrotic muscle tissues of the wound and then wrap the wound. Western medicine does not advocate the application of drugs on the wound surface, mainly takes internal drugs (such as anti-inflammatory and analgesic drugs), and the method looks scientific, has not ideal actual effect and is expensive.

The traditional Chinese medicine for externally treating burns and scalds in China is more, and the commercially available medicines have certain curative effects, but the traditional Chinese medicine also has the conditions of large dosage, need of multiple smearing and medication, long treatment time, easy wound infection, slow scabbing, poor pain relieving effect, insufficient moistening degree, secondary injury and subsequent scar remaining.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a preparation for treating burns and scalds and a preparation method thereof.

The technical scheme adopted by the invention is as follows: a preparation for treating burns and scalds is mainly prepared from the following raw materials in parts by mass:

10-40 parts of poppy flower, 0.15-1.5 parts of musk, 5-30 parts of sophora japonica branch, 5-30 parts of garden burnet root, 5-30 parts of cortex lycii radicis, 5-30 parts of lithospermum, 5-20 parts of coptis chinensis, 5-20 parts of rheum officinale, 5-20 parts of crinis carbonisatus, 5-20 parts of dark plum, 5-20 parts of angelica dahurica, 5-30 parts of radix rehmanniae, 2-10 parts of borneol, 35-140 parts of a hardening agent and 1000 parts of an oil agent 250.

Said invention provides a preparation for curing burn and scald, and said preparation adopts oil as base, and is compatible with various raw materials with the functions of clearing away heat and toxic material, relieving pain and diminishing inflammation, promoting blood circulation and removing blood stasis, removing necrosis and promoting granulation so as to attain the goal of moistening, quickly relieving pain and having no secondary wound surface injury. The preparation can be used for treating burn, scald, hemorrhoid, and chilblain. Does not need skin grafting or limb amputation, has extremely strong functions of preventing infection, resisting infection and treating infection, has safety and better protective effect on users, and does not leave scars after treatment.

Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:

15-30 parts of poppy flower, 0.3-0.75 part of musk, 10-25 parts of sophora japonica branch, 10-25 parts of garden burnet root, 10-25 parts of cortex lycii radicis, 10-25 parts of lithospermum, 8-15 parts of coptis chinensis, 8-15 parts of rheum officinale, 8-15 parts of crinis carbonisatus, 8-15 parts of dark plum, 8-15 parts of angelica dahurica, 10-25 parts of radix rehmanniae, 4-7 parts of borneol, 56-100 parts of a hardening agent and 750 parts of an oil agent 400.

20 parts of poppy flower, 0.5 part of musk, 15 parts of sophora japonica branch, 15 parts of garden burnet root, 15 parts of cortex lycii radicis, 15 parts of lithospermum, 10 parts of coptis chinensis, 10 parts of rheum officinale, 10 parts of crinis carbonisatus, 10 parts of dark plum, 10 parts of angelica dahurica, 15 parts of radix rehmanniae, 5 parts of borneol, 70 parts of a hardening agent and 500 parts of an oil agent.

Poppy flower (the name of Papaver somniferum) is a plant of the Papaveraceae family, and is the main raw material for preparing opium. Alias: opium flower, Lichun flower, dancing grass, petunia, Paeonia suffruticosa and British flower, the flower is big and gorgeous, the fragrance is strong, and the flower is one of the most beautiful flowers in the world. Early flowering, spherical capsule fruit with tiny and numerous seeds. It contains morphine, cocaine and other substances, is easy to addict after being eaten excessively, but is also a valuable ornamental plant. Poppy shell is sour and astringent in taste, toxic, contains more than 30 alkaloids such as morphine, codeine, narcotine and papaverine, is analgesic, antitussive and antidiarrheal, and can be used for treating lung deficiency, chronic cough, various pains of chest, abdomen, tendons and bones, and chronic dysentery; it is also used for treating spermatorrhea and spermatorrhea due to kidney deficiency.

Musk, name of drug. It is recorded in Shen nong Ben Cao Jing. Also named as cun xiang, yuan cun, dangmen, weizi and xiang umbilicus. Is dried secretion of Moschus berezovski Flerov. maschus m.sifusPrzewalski or original musks m.mosciferus L.androgens of deer animal. Mainly produced in Sichuan, Tibet, Yunnan, Shaanxi, Gansu, inner Mongolia and other places. Pungent and warm. Enter heart, spleen and liver meridians. Induce resuscitation, activate blood, dissipate nodulation and alleviate pain. Drying, making into granule or block, with special fragrance and bitter taste, and making into spice or medicine. Is a central nerve stimulant, can relieve pain and reduce swelling when being externally used, and is also very precious.

Preferably, the hardening agent comprises a yellow wax.

Preferably, the oil agent comprises sesame oil and/or linseed oil.

The preparation is prepared by squeezing dried Mel from Mel nidus Vespae, and decocting with water. Has astringent, sore healing, granulation promoting, and analgesic effects. It is indicated for unhealed ulcer, wound, burn and scald. The Chinese medicinal yellow wax is wax secreted by Apidae Apis cerana Fabricius, and is made into block by artificial refining. In spring and autumn, the honey-removed honeycomb is put into a water pot to be heated and melted, upper layer foam impurities are removed, and the honeycomb is filtered while the honeycomb is hot. The yellow wax has the following effects: detoxification; promoting granulation; stopping dysentery; hemostasis is carried out; relieving pain. Mainly treats carbuncle, deep-rooted carbuncle and ulcer on the back, and astringes the ulcer; diarrhea with purulent blood; acute heartburn; chronic diarrhea; spermatorrhea; leucorrhea; bleeding during fetal movement. The chemical components of the traditional Chinese medicine beeswax are slightly different due to different bee species and production areas, and the main chemical components comprise 14% of carbohydrate, 42% of monoester, 14% of diester, 3% of triester, 4% of hydroxyl monoester, 8% of hydroxyl polyester, 1% of acidic polyester, 12% of free acid and 2% of other substances. In addition, the yellow wax also contains carotenoid, vitamin A, a small amount of aromatic substances, pigment, trace elements and the like. According to the traditional Chinese medicine, the yellow wax is sweet and light in taste and neutral in nature, and enters lung, stomach and large intestine channels. Has effects in removing toxic materials, relieving pain, nourishing skin, stopping dysentery, and stopping bleeding.

The sesame oil and the sesame oil are rich in vitamin E and linolenic acid, wherein the vitamin E has an antioxidation effect, can maintain the integrity and the normal function of cell membranes, and has the effects of promoting cell division, softening blood vessels and keeping the elasticity of the blood vessels, thereby being beneficial to protecting the cardiovascular and cerebrovascular vessels. And the linoleic acid, the palmitic acid and other unsaturated fatty acids in the sesame oil are easily absorbed by human bodies, are beneficial to eliminating deposits on arterial walls and also have the effect of protecting blood vessels. In addition, sesame oil has a strong flavor, can stimulate appetite to a certain extent, and promotes the absorption of nutrient components in vivo, such as sesame, vitamin E, vitamin B1, linoleic acid, protein, sesame sugar, pentosan, calcium, phosphorus, iron and other mineral substances and various rich nutrient components. The most abundant of them is vitamin E, which is the main component, and is also called anti-aging vitamin. It has good effects of improving blood circulation and promoting metabolism. And linoleic acid which is an unsaturated fatty acid, which has a function of regulating cholesterol.

The linseed oil has sweet smell, is slightly cold and is nontoxic. The medicine is mainly used for benefiting large intestine and preventing the falling of the placenta of a lying-in woman. Oil producing, skin ulcer swelling, alopecia (Bian Lu). Removing the head and the face. It mainly promotes the flow of heat in the sky and causes heat accumulation in the intestines. Take the combination and take the right of the profit as the degree (Tibetan). Mainly hoarse, kill the five yellows, remove the heat-toxin gas of the triple energizer, when less, it is very good (damp) to purge the heat-toxin. Aging oil: decocting to obtain paste, promoting granulation, relieving pain, removing carbuncle and swelling, and nourishing skin. For abscess deep-rooted carbuncle and heat disease (Susong). Relieving heat toxin, food toxin and insect toxin, and killing all the insects, namely the mole and ant (Shizhen). The flax seeds contain 6 to 10 percent of flax gum. The flax gum is a pectin substance mainly containing polysaccharide, contains 12% of protein, about 17% of pectic acid, starch, mineral substances, etc., and can be used as food additive, cosmetic raw powder, medicinal material, etc. Linseed oil is a high-quality edible oil, is rich in alpha-linolenic acid and various unsaturated fatty acids, and can be directly converted into DHA and EPA in a human body. The linseed oil contains 48 percent of linolenic acid, which is the highest in vegetable oil and is an economical and practical 'deep sea fish oil'. It is known that "fish oil" refers to EPA and DHA, which are produced in the body of fish by alpha-linolenic acid from the sea (mainly contained in seaweed). When people take the alpha-linolenic acid (mainly contained in the linseed oil), EPA and DHA are also synthesized in vivo. Therefore, the eating of the linseed oil rich in the alpha-linolenic acid can achieve the effect similar to the eating of 'fish oil'; repairing unsaturated fatty acid chain of brain nerve cell membrane, strengthening brain, improving intelligence, reducing blood lipid, resisting platelet aggregation, dilating arteriole, and preventing thrombosis.

A preparation method of a preparation for treating burn and scald comprises selecting oil according to a corresponding proportion, heating, adding poppy flower, musk, sophora twig, garden burnet root, cortex lycii radicis, lithospermum, coptis root, rhubarb, crinis carbonisatus, dark plum, angelica dahurica and radix rehmanniae, processing until the raw materials are brown, removing dregs of a decoction, adding a hardening agent and borneol, uniformly mixing, and cooling to obtain a finished product.

The preparation for treating burns and scalds selects the oil agent as the substrate to process various traditional Chinese medicinal materials in the preparation process, and the oil processing mode can promote the effective components in the traditional Chinese medicinal materials to be fully dispersed into the oil agent and can well remove the slightly cold characteristic of partial raw materials, thereby obtaining a product which is more suitable for use. By adding the hardening agent and the borneol, the effects of healing sore and promoting granulation and clearing heat and relieving pain are further achieved, the finished product is effectively condensed into paste, and the paste is beneficial to transportation, storage and subsequent use. The processed Chinese medicinal materials are brown, and have hemostatic and toxic materials clearing away effects.

Preferably, the processing temperature is 150-200 ℃.

Preferably, the processing time is 30-60 minutes.

Preferably, the finished product is an external preparation.

Preferably, the finished product is in the form of a paste.

The above-mentioned setting of the processing temperature and duration is to prolong the processing duration as much as possible on the premise that the Chinese herbal medicines have the processing function, so as to ensure that the effective components of the Chinese herbal medicines can penetrate into the oil agent to the maximum extent, thereby ensuring the high-efficiency therapeutic property of the finished product.

The invention has the beneficial effects that:

the invention provides a preparation for treating burns and scalds, which adopts oil as a substrate and is compatible with various raw materials with the functions of clearing away heat and toxic material, relieving pain and inflammation, promoting blood circulation, removing blood stasis, removing necrotic tissue and promoting granulation, thereby achieving the effects of high moisture, quick pain relief and no secondary wound injury. The preparation can be used for treating burn, scald, hemorrhoid, and chilblain. Does not need skin grafting or limb amputation, has extremely strong functions of preventing infection, resisting infection and treating infection, has safety and better protective effect on users, and does not leave scars after treatment.

The preparation for treating burns and scalds selects the oil agent as a substrate to process various traditional Chinese medicinal materials in the preparation process, and the oil processing mode can promote the effective components in the traditional Chinese medicinal materials to be fully dispersed into the oil agent and can well remove the slightly cold characteristic of partial raw materials, thereby obtaining a product which is more suitable for use. The processing temperature and the processing time are set, so that the processing time is prolonged as far as possible on the premise that the Chinese herbal medicines have the processing effect, the effective components of the Chinese herbal medicines can be ensured to permeate into the oil agent to the maximum extent, and the high-efficiency treatment performance of the finished product is ensured.

By adding the hardening agent and the borneol, the effects of healing sore and promoting granulation and clearing heat and relieving pain are further achieved, the finished product is effectively condensed into paste, and the paste is beneficial to transportation, storage and subsequent use. The processed Chinese medicinal materials are brown, and have hemostatic and toxic materials clearing away effects.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

a preparation method of a preparation for treating burns and scalds comprises the steps of selecting 250 g of sesame oil according to a corresponding proportion, heating, adding 10 g of poppy flower, 0.15 g of musk, 5 g of sophora twig, 5 g of garden burnet root, 5 g of cortex lycii radicis, 5 g of lithospermum, 5 g of coptis chinensis, 5 g of rheum officinale, 5 g of crinis carbonisatus, 5 g of dark plum, 5 g of angelica dahurica and 5 g of radix rehmanniae, processing for 60 minutes at 150 ℃, removing dregs of a decoction when the raw materials are brown, adding 35 g of beeswax and 2 g of borneol, uniformly stirring, and cooling to obtain a paste finished product.

The oil preparation is heated and then Chinese herbal medicines are added, which belongs to the conventional oil preparation mode in the field of traditional Chinese medicine, and the actual operation of the oil temperature and the preparation temperature can be set correspondingly according to the actually selected genuine medicinal materials or the preparation environment.

Example 2:

a preparation method of a preparation for treating burns and scalds comprises the steps of selecting 1000 g of sesame oil according to a corresponding proportion, heating, adding 40 g of poppy flowers, 1.5 g of musk, 30 g of sophora japonica branches, 30 g of garden burnet roots, 30 g of cortex lycii radicis, 30 g of lithospermum, 20 g of coptis chinensis, 20 g of rheum officinale, 20 g of crinis carbonisatus, 20 g of dark plum, 20 g of angelica dahurica and 30 g of radix rehmanniae, processing for 30 minutes at 220 ℃, removing dregs of a decoction when the raw materials are brown, adding 140 g of yellow wax and 10 g of borneol, uniformly stirring, and cooling to obtain a paste finished product.

Example 3:

a preparation method of a preparation for treating burns and scalds comprises the steps of selecting 400 g of linseed oil according to a corresponding proportion, heating, adding 15 g of poppy flowers, 0.3 g of musk, 10 g of sophora japonica branches, 10 g of garden burnet roots, 10 g of cortex lycii radicis, 10 g of lithospermum, 8 g of coptis chinensis, 8 g of rheum officinale, 8 g of crinis carbonisatus, 8 g of dark plums, 8 g of angelica dahurica and 10 g of radix rehmanniae, processing for 60 minutes at 150 ℃, removing dregs of a decoction when the raw materials are brown, adding 56 g of yellow wax and 4 g of borneol uniformly, and cooling to obtain a paste finished product.

Example 4:

a preparation method of a preparation for treating burns and scalds comprises the steps of selecting 750 g of linseed oil according to a corresponding proportion, heating, adding 30 g of poppy flowers, 0.75 g of musk, 25 g of sophora japonica branches, 25 g of garden burnet roots, 25 g of cortex lycii radicis, 25 g of lithospermum, 15 g of coptis roots, 15 g of rheum officinale, 15 g of crinis carbonisatus, 15 g of dark plums, 15 g of angelica dahurica and 25 g of radix rehmanniae, processing for 30 minutes at 220 ℃, removing dregs of a decoction when the raw materials are brown, adding 100 g of yellow wax and 7 g of borneol uniformly, and cooling to obtain a paste finished product.

Example 5:

a preparation method of a preparation for treating burns and scalds comprises the steps of selecting 500 g of linseed oil according to a corresponding proportion, heating, adding 20 g of poppy flowers, 0.5 g of musk, 15 g of sophora japonica branches, 15 g of garden burnet roots, 15 g of cortex lycii radicis, 15 g of lithospermum, 10 g of coptis chinensis, 10 g of rheum officinale, 10 g of crinis carbonisatus, 10 g of dark plums, 10 g of angelica dahurica and 15 g of radix rehmanniae, processing for 30 minutes at 220 ℃, removing dregs of a decoction when the raw materials are brown, adding 70 g of yellow wax and 5 g of borneol uniformly, and cooling to obtain a paste finished product.

The using method comprises the following steps: the prepared paste product is uniformly coated on gauze with the thickness of about 2-3mm, and is pasted on an affected part and replaced once in 24 hours.

Clinical cases:

patient 1: male, 20 years old, Shandong. The tricycle turns over, which causes the tricycle water tank to directly press to a patient, and large-area scald is caused to the back, the arms, the hip and the hand back. The treatment is carried out by infusion and smearing ointment in county hospitals, and the treatment effect is not ideal.

The treatment mode comprises the following steps: the paste-like finished product of example 5 was used for patch application.

The treatment results are as follows: the parts (the arms and the back of the hand) with light scald degree can be healed in 4-5 days; the groin and the back of the hip are healed within 10-12 days.

Patient 2: male, 18 years old, human in the south of Henan. Hospital determination was 81% grade scald. The family belongs to Henan Fang county, and no improvement is seen after 18 days of treatment in hospitals in county. Transferring to the army hospital of Anyang for 43 days, treating for a plurality of infections during the treatment period, removing pus every day, requiring skin grafting treatment in the hospital, extremely high skin grafting cost and subsequent maintenance cost, and being incapable of supporting the economy of patients.

The treatment results are as follows: after 53 days of treatment, the affected part heals.

Patient 3: female, 35 years old, human in Henan. The patient has the pre-symptoms of epilepsy, and after sitting on a coal ball stove in a squatting mode, the patient can burn a large area of buttocks, and the skin on the surface layer is in a blackened state.

The treatment results are as follows: after 29 treatments, the affected parts all got better.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The preparation for treating burns and scalds is characterized by being prepared from the following raw materials in parts by mass:

2. The preparation for treating burns and scalds according to claim 1, which is prepared from the following raw materials in parts by mass:

3. The preparation for treating burns and scalds according to claim 2, which is prepared from the following raw materials in parts by mass:

4. The formulation for treating burns and scalds according to any one of claims 1 to 3, wherein the hardening agent comprises beeswax.

5. The preparation for treating burns and scalds according to any one of claims 1 to 3, wherein the oil agent comprises sesame oil and/or linseed oil.

6. A preparation method of a preparation for treating burns and scalds according to any one of claims 1 to 5, which is characterized in that the method comprises the steps of selecting oil according to corresponding proportions, heating, adding poppy flowers, musk, sophora japonica branches, garden burnet roots, cortex lycii radicis, lithospermum, coptis roots, rheum officinale, crinis carbonisatus, dark plum, angelica dahurica and radix rehmanniae, processing, removing dregs of a decoction, adding a hardening agent and borneol, uniformly mixing, and cooling to obtain a finished product.

7. The method for preparing a preparation for treating burns and scalds as claimed in claim 6, wherein the processing temperature is 150 ℃ and 200 ℃.

8. The preparation method of the preparation for treating burns and scalds according to claim 6, wherein the processing time is 30-60 minutes.

9. The preparation method of the preparation for treating burns and scalds according to claim 6, wherein the finished product is an external preparation.

10. The method for preparing a preparation for treating burn and scald as claimed in claim 9, wherein said product is in the form of paste.