CN108159256A - A kind of honey Chinese herbal medicine unguentum perniosis agent and preparation method thereof - Google Patents
A kind of honey Chinese herbal medicine unguentum perniosis agent and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of honey Chinese herbal medicine unguentum perniosis agent and preparation method thereof, and honey, raw milk, dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns, Japanese raisintree fruit and other compositions are included in formula；In invention formula, the addition of ficus simplicissima and three plumage crescent fern ingredients makes the agent of gained honey Chinese herbal medicine unguentum perniosis have antiinflammation, combines with red sage, can also reach antipruritic effect simultaneously；Three taste Chinese medicine of insane eggplant, east mistletoe and chinaroot greenbrier in formula so that the agent of gained honey Chinese herbal medicine unguentum perniosis has detumescence effect；Honey raisin tree subconstiuent in ingredient has effects that relieve pain suppuration, can remove the purulence blood in frostbite, wound is made to heal as early as possible, promotes newborn skin growth, not only can reach the purpose for the treatment of pernio, also can obviously improve frostbite it is good after the scar that leaves.
Description
Technical field
The present invention relates to ointment technical fields, and in particular to a kind of honey Chinese herbal medicine unguentum perniosis agent and its preparation side
Method.
Background technology
Honey is a kind of sticky, transparent or semitransparent colloidal liquid, mainly contains glucose, fructose, sucrose and wheat
Bud sugar is a kind of full of nutrition also containing substances such as micro amino acids, vitamin, enzyme, yeast, pollen grain and waxes
Natural nourishing product.
Pernio is a kind of seasonal common disease and common disease.Pernio generation is since winter low temperature makes certain susceptible persons sudden and violent
The dermis of skin capillary and parteriole for revealing position are shunk, and time slightly length causes histanoxia, and tissue is expanded in paralytic, effect
Venous congestion, more very, intravenous extravasation to tissue generates the pernio symptoms such as erythema oedema for blood vessel dilatation after heated.
In the prior art, treat pernio drug or skin care item based on chemical composition, be aided with other ingredients, gained production
Product to the therapeutic effect unobvious of pernio, and the use of chemical reagent have to human body it is potentially hazardous.
Invention content
The present invention is directed to prior art defect, it is intended that providing one kind has anti-inflammatory, analgesic, detumescence, has to frostbite notable
Honey Chinese herbal medicine unguentum perniosis agent of therapeutic effect and preparation method thereof.
To achieve the above objectives, technical solution of the present invention is as follows：
A kind of honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：Include following component：
Natural component：Honey, raw milk；
Medicinal herb components：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns
And Japanese raisintree fruit；
Other ingredients：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride；
Wherein, natural component:Traditional Chinese medicine ingredients:The weight ratio of other ingredients is 5:3:2.
Preferably, the honey:The weight ratio of raw milk is 6:4.
Preferably, the glycerine:Palmitic acid fat:Sodium Hyaluronate:The mass ratio of sodium chloride is 4: 2 :
3 : 1。
Preferably, the traditional Chinese medicine ingredients weigh by weight, respectively：15 ~ 40 parts of dalbergia wood, 23 ~ 50 parts of radix semiaquilegiae, Radix Ophiopogonis
13 ~ 35 parts, 16 ~ 32 parts of insane eggplant, 15 ~ 31 parts of east mistletoe, 20 ~ 35 parts of chinaroot greenbrier, 12 ~ 23 parts of red sage, ficus simplicissima 35 ~ 56
Part, three 33 ~ 60 parts of plumage crescent ferns, 30 ~ 54 parts of Japanese raisintree fruit.
Preferably, the traditional Chinese medicine ingredients weigh by weight, respectively：35 parts of dalbergia wood, 30 parts of radix semiaquilegiae, 20 parts of Radix Ophiopogonis,
Insane 25 parts of eggplant, 23 parts of east mistletoe, 28 parts of chinaroot greenbrier, 18 parts of red sage, 38 parts of ficus simplicissima, three 40 parts of plumage crescent ferns, Japanese raisintree fruit
42 parts.
A kind of preparation method of honey Chinese herbal medicine unguentum perniosis agent comprises the steps of：
（1）Honey is diluted with water, by adding water honey water content between 25 ~ 30%, agitating and heating, and 65 ~ 75 DEG C of heating temperature,
0.5 ~ 1h of heating time crosses 150 mesh sieve, obtains honey liquid juice；
（2）It weighs respectively by weight：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima and
Three plumage crescent ferns, clean up after mixing, are 1g by solid-liquid ratio:The ratio of 20mL adds water, agitating and heating, heating temperature 85 ~ 95
DEG C, 1.5 ~ 2h of heating time crosses 200 mesh sieve, obtains the pure extracting solution of Chinese medicine；
（3）By step（2）The pure extracting solution of gained Chinese medicine and step（1）Gained honey liquid juice presses 2:3 volume ratio mixing
Uniformly, agitating and heating, 45 ~ 50 DEG C of heating temperature, heating time 0.5h obtain mixing liquid；
（4）Japanese raisintree fruit is weighed by weight, is cleaned up, by 1g:The ratio of 10mL admixes sea red fruit wine, is sealed 1 ~ 2 day
After take out, naturally dry, milling sieve with 100 mesh sieve, and obtain Japanese raisintree fruit powder；
（5）In step（3）It is sequentially added in gained mixing liquid：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride,
Agitating and heating, 65 DEG C of heating temperature, 0.5 ~ 1h of heating time obtain mixture；
（6）In step（5）Step is added in gained mixture（4）Gained Japanese raisintree fruit powder and raw milk, agitating and heating, heating temperature
40 ~ 50 DEG C, 1.5 ~ 2h of heating time of degree, crosses 200 mesh sieve, concentration, control water content 5 ~ 10%, after sterilize, sterilising temp
85 DEG C, sterilization time 20min；It is cooled down after sterilizing, it is filling, obtain honey Chinese herbal medicine unguentum perniosis agent finished product.
The present invention has the following advantages：
（1）In inventive formulation, the addition of ficus simplicissima and three plumage crescent fern ingredients makes gained honey Chinese herbal medicine unguentum perniosis agent tool
There is antiinflammation, combine with red sage, can also reach antipruritic effect simultaneously；Three taste of insane eggplant, east mistletoe and chinaroot greenbrier in formula
Chinese medicine so that the agent of gained honey Chinese herbal medicine unguentum perniosis has detumescence effect；There is honey raisin tree subconstiuent in ingredient analgesic to suppurate
Effect can remove the purulence blood in frostbite, wound is made to heal as early as possible, promote newborn skin growth, not only can reach treatment pernio
Purpose, also can obviously improve frostbite it is good after the scar that leaves；
（2）In inventive formulation, the function and effect that have using the natural anti-oxidation ingredient of honey so that do not adding preservative
Under conditions of, it can also extend product storage period, and avoid potential hazard of the use to pernio wound of preservative, contain in honey
Remaining nutritional ingredient having can be also utilized, to play the role of promoting wound healing.
Specific embodiment
With reference to specific embodiment, the technical solution that the present invention will be described in detail.
Embodiment 1
A kind of honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：Include following component：
Natural component：Honey, raw milk；
Medicinal herb components：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns
And Japanese raisintree fruit；
Other ingredients：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride；
Wherein, natural component:Traditional Chinese medicine ingredients:The weight ratio of other ingredients is 5:3:2；The honey:The weight of raw milk
Amount is than being 6:4；The glycerine:Palmitic acid fat:Sodium Hyaluronate:The mass ratio of sodium chloride is：4 : 2 : 3 :
1；
A kind of preparation method of honey Chinese herbal medicine unguentum perniosis agent comprises the steps of：
（1）Honey is diluted with water, by adding water honey water content between 25 ~ 30%, agitating and heating, and 65 DEG C of heating temperature, heating
Time 1h crosses 150 mesh sieve, obtains honey liquid juice；
（2）It weighs respectively by weight：15 parts of dalbergia wood, 23 parts of radix semiaquilegiae, 13 parts of Radix Ophiopogonis, 16 parts of insane eggplant, 15 parts of east mistletoe,
20 parts of chinaroot greenbrier, 12 parts of red sage, 35 parts of ficus simplicissima, three 33 parts of plumage crescent ferns, clean up after mixing, are 1g by solid-liquid ratio:
The ratio of 20mL adds water, agitating and heating, and 85 DEG C, heating time 2h of heating temperature crosses 200 mesh sieve, obtains the pure extracting solution of Chinese medicine；
（3）By step（2）The pure extracting solution of gained Chinese medicine and step（1）Gained honey liquid juice presses 2:3 volume ratio mixing
Uniformly, agitating and heating, 45 DEG C of heating temperature, heating time 0.5h obtain mixing liquid；
（4）30 parts of Japanese raisintree fruits are weighed by weight, are cleaned up, by 1g:The ratio of 10mL admixes sea red fruit wine, is sealed 1
It is taken out after it, naturally dry, milling sieve with 100 mesh sieve, and obtain Japanese raisintree fruit powder；
（5）In step（3）It is sequentially added in gained mixing liquid：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride,
Agitating and heating, 65 DEG C of heating temperature, heating time 0.5h obtain mixture；
（6）In step（5）Step is added in gained mixture（4）Gained Japanese raisintree fruit powder and raw milk, agitating and heating, heating temperature
40 DEG C, heating time 2h of degree, crosses 200 mesh sieve, concentration, control water content 5 ~ 10%, after sterilize, 85 DEG C of sterilising temp goes out
Bacterium time 20min；It is cooled down after sterilizing, it is filling, obtain honey Chinese herbal medicine unguentum perniosis agent finished product.
Embodiment 2
A kind of honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：Include following component：
Natural component：Honey, raw milk；
Medicinal herb components：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns
And Japanese raisintree fruit；
Other ingredients：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride；
Wherein, natural component:Traditional Chinese medicine ingredients:The weight ratio of other ingredients is 5:3:2；The honey:The weight of raw milk
Amount is than being 6:4；The glycerine:Palmitic acid fat:Sodium Hyaluronate:The mass ratio of sodium chloride is：4 : 2 : 3 :
1；
A kind of preparation method of honey Chinese herbal medicine unguentum perniosis agent comprises the steps of：
（1）Honey is diluted with water, by adding water honey water content between 25 ~ 30%, agitating and heating, and 75 DEG C of heating temperature, heating
Time 0.5h crosses 150 mesh sieve, obtains honey liquid juice；
（2）It weighs respectively by weight：40 parts of dalbergia wood, 50 parts of radix semiaquilegiae, 35 parts of Radix Ophiopogonis, 32 parts of insane eggplant, 31 parts of east mistletoe,
35 parts of chinaroot greenbrier, 23 parts of red sage, 56 parts of ficus simplicissima, three 60 parts of plumage crescent ferns, clean up after mixing, are 1g by solid-liquid ratio:
The ratio of 20mL adds water, agitating and heating, and 95 DEG C, heating time 1.5h of heating temperature crosses 200 mesh sieve, obtains the pure extracting solution of Chinese medicine；
（3）By step（2）The pure extracting solution of gained Chinese medicine and step（1）Gained honey liquid juice presses 2:3 volume ratio mixing
Uniformly, agitating and heating, 50 DEG C of heating temperature, heating time 0.5h obtain mixing liquid；
（4）54 parts of Japanese raisintree fruits are weighed by weight, are cleaned up, by 1g:The ratio of 10mL admixes sea red fruit wine, is sealed 2
It is taken out after it, naturally dry, milling sieve with 100 mesh sieve, and obtain Japanese raisintree fruit powder；
（5）In step（3）It is sequentially added in gained mixing liquid：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride,
Agitating and heating, 65 DEG C of heating temperature, heating time 1h obtain mixture；
（6）In step（5）Step is added in gained mixture（4）Gained Japanese raisintree fruit powder and raw milk, agitating and heating, heating temperature
50 DEG C, heating time 1.5h of degree, crosses 200 mesh sieve, concentration, control water content 5 ~ 10%, after sterilize, 85 DEG C of sterilising temp,
Sterilization time 20min；It is cooled down after sterilizing, it is filling, obtain honey Chinese herbal medicine unguentum perniosis agent finished product.
Embodiment 3
A kind of honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：Include following component：
Natural component：Honey, raw milk；
Medicinal herb components：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns
And Japanese raisintree fruit；
Other ingredients：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride；
Wherein, natural component:Traditional Chinese medicine ingredients:The weight ratio of other ingredients is 5:3:2；The honey:The weight of raw milk
Amount is than being 6:4；The glycerine:Palmitic acid fat:Sodium Hyaluronate:The mass ratio of sodium chloride is：4 : 2 : 3 :
1；
A kind of preparation method of honey Chinese herbal medicine unguentum perniosis agent comprises the steps of：
（1）Honey is diluted with water, by adding water honey water content between 25 ~ 30%, agitating and heating, and 70 DEG C of heating temperature, heating
Time 1h crosses 150 mesh sieve, obtains honey liquid juice；
（2）It weighs respectively by weight：35 parts of dalbergia wood, 30 parts of radix semiaquilegiae, 20 parts of Radix Ophiopogonis, 25 parts of insane eggplant, 23 parts of east mistletoe,
28 parts of chinaroot greenbrier, 18 parts of red sage, 38 parts of ficus simplicissima and three 40 parts of plumage crescent ferns, clean up after mixing, are 1g by solid-liquid ratio:
The ratio of 20mL adds water, agitating and heating, and 90 DEG C, heating time 1.5h of heating temperature crosses 200 mesh sieve, obtains the pure extracting solution of Chinese medicine；
（3）By step（2）The pure extracting solution of gained Chinese medicine and step（1）Gained honey liquid juice presses 2:3 volume ratio mixing
Uniformly, agitating and heating, 50 DEG C of heating temperature, heating time 0.5h obtain mixing liquid；
（4）42 parts of Japanese raisintree fruits are weighed by weight, are cleaned up, by 1g:The ratio of 10mL admixes sea red fruit wine, is sealed 2
It is taken out after it, naturally dry, milling sieve with 100 mesh sieve, and obtain Japanese raisintree fruit powder；
（5）In step（3）It is sequentially added in gained mixing liquid：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride,
Agitating and heating, 65 DEG C of heating temperature, heating time 1h obtain mixture；
（6）In step（5）Step is added in gained mixture（4）Gained Japanese raisintree fruit powder and raw milk, agitating and heating, heating temperature
50 DEG C, heating time 2h of degree, crosses 200 mesh sieve, concentration, control water content 5 ~ 10%, after sterilize, 85 DEG C of sterilising temp goes out
Bacterium time 20min；It is cooled down after sterilizing, it is filling, obtain honey Chinese herbal medicine unguentum perniosis agent finished product.
Honey Chinese herbal medicine unguentum perniosis agent physics and chemistry detects
1. chemical property
（1）Granularity
According to《Chinese Pharmacopoeia》Version in 2010 is detected according to the first methods of annex Ι X E；
Testing result is：Granularity is less than 180 μm, meets regulation；
（2）Microbial limit
According to《Chinese Pharmacopoeia》Version in 2010 is detected according to annex X Ι J；
Honey Chinese herbal medicine unguentum perniosis agent 10g prepared by Example 1 is added to containing sterile isopropyl myristates of 20mL and sterile
In the appropriate vessel of bead, then add in 45 DEG C plus pH7.0 sterile NaCls-peptone buffer agent to 100mL, concussion 5 ~
10min, extraction, standing make grease significantly be layered, take its water layer as sample to be tested.Take 3 parts of sample to be tested 1mL, successively with carefully
Bacterium culture medium, mould medium and microzyme culture medium press 1:The ratio mixing of 50mL respectively takes 1mL respectively, is implanted sequentially bacterium
It in culture medium, mould medium and saccharomycete culture, is uniformly mixed, solidifies, culture, wherein, the culture dimension of bacterium is 30 ~ 35
DEG C, mould, saccharomycete cultivation temperature be 23 ~ 28 DEG C；Culture counts afterwards for 24 hours, and method of counting is：It is noted per 1mL test liquids
The sum of clump count grown in plate is the clump count of 1mL, the average colony number per 1mL test liquids is calculated, based on Plating
Number rule report bacterium number；
Note：Above-mentioned experiment is carried out in sterile room；
Experimental result is：56 CFU/ mL ＜ 100CFU/mL of total number of molds；
43 CFU/mL ＜ 100CFU/mL of saccharomycete sum；
105 CFU/mL ＜ 1000CFU/mL of total number of bacteria；
Therefore, the honey Chinese herbal medicine unguentum perniosis agent of present invention gained meets sanitary standard；
2. physical property
（1）Physical appearance
Gained honey Chinese herbal medicine unguentum perniosis agent uniform color of the invention is consistent, and quality is fine and smooth, and no harsh feeling, no dirt meets
Regulation；
（2）Irritation
Gained honey Chinese herbal medicine unguentum perniosis agent of the invention is to skin, mucous membrane is non-stimulated or sensitization, meets regulation；
（3）Stability
Present invention gained honey Chinese herbal medicine unguentum perniosis agent sample prepared by Example 1, is respectively placed in 55 DEG C of constant temperature 6h and -15
DEG C place for 24 hours, observation；As a result it is：Without water-oil separating；Therefore, products obtained therefrom stability of the present invention complies with standard；
（4）pH
Implemented according to prescriptive procedure in national standard GB/T 13531.1：
As a result it is：PH is 6.7, meet pH should 4.4 ~ 8.3 regulation.
The performance test of honey Chinese herbal medicine unguentum perniosis agent
Blank group：Physiological saline group；
Control group 1：Honey Chinese herbal medicine unguentum perniosis agent, preparation method are：Ficus simplicissima and three plumage crescent ferns are free of in formula, remaining
Ingredient and the preparation method is the same as that of Example 1；
Control group 2：Honey Chinese herbal medicine unguentum perniosis agent, preparation method are：Red sage, remaining ingredient and preparation side are free of in formula
Method is the same as embodiment 1；
Control group 3：Honey Chinese herbal medicine unguentum perniosis agent, preparation method are：Insane eggplant, east mistletoe and chinaroot greenbrier are free of in formula,
Remaining ingredient and the preparation method is the same as that of Example 1；
Control group 4：Honey Chinese herbal medicine unguentum perniosis agent, preparation method are：Japanese raisintree fruit, remaining ingredient and preparation side are free of in formula
Method is the same as embodiment 1；
Control group 5：Commercially available section field board kibe ointment；
Experimental group：Honey Chinese herbal medicine unguentum perniosis agent prepared by embodiment 1；
60 Kunming mouses are taken, 20 ± 1g of weight, laboratory is fed 2 days, to adapt to ambient enviroment.Be randomly divided into A, B, C, D,
E, 6 groups of F, every group 10；Before and after dimethylbenzene 0.03mL is applied to the left ear of mouse, auris dextra is not painted with control, until 40min after scorching；
A groups：The smearing physiological saline at the left ear to inflammation of mouse, applying amount 1mL, 2 times a day；
B groups：The honey Chinese herbal medicine unguentum perniosis agent of smearing control group 1 at the left ear to inflammation of mouse, applying amount 1g, 2 times a day；
C groups：The honey Chinese herbal medicine unguentum perniosis agent of smearing control group 2 at the left ear to inflammation of mouse, applying amount 1g, 2 times a day；
D groups：The honey Chinese herbal medicine unguentum perniosis agent of smearing control group 3 at the left ear to inflammation of mouse, applying amount 1g, 2 times a day；
E groups：The commercially available section field board kibe ointment of smearing control group 5 at the left ear to inflammation of mouse, applying amount 1g, 2 times a day；
F groups：The honey Chinese herbal medicine unguentum perniosis agent of smearing experimental group at the left ear to inflammation of mouse, applying amount 1g, 2 times a day；
After continuous processing 2 days, the left otitis disease of observation mouse, swelling situation, and compared with auris dextra；Observe and record mouse per hour
Scratch ear number（Note：To scratch the antipruritic effect of ear number evaluation experimental sample）, it is averaged, the results are shown in Table 1：
By conclusion in table 1 it is found that B groups, E groups and the comparison of F groups are it is found that ficus simplicissima and three plumage crescent ferns in formula are treatment inflammation
Main component, and significant effect；Comparison B groups, C groups and D group mouse scratch ear number it is found that red sage be the key that it is antipruritic into
Point, and after combining with ficus simplicissima and three plumage crescent ferns, drug effect becomes apparent from；Compared with F groups, it is more that D group mouse scratch ear number, be because
For D group laboratory samples lack three taste Chinese medicine of insane eggplant, east mistletoe and chinaroot greenbrier, lead to the left ear swelling of mouse, increase and scratch ear
Number, therefore, can also obtain, this three tastes Chinese medicine is that F group test specimens have effects that the factor for eliminating swelling, and effect is than commercially available
Section's field board kibe ointment significantly；
Using the analgesic effect of the honey Chinese herbal medicine ointment of the hot plate method test present invention：Female mice 50 is taken, is placed on heating
To 60 DEG C of metallic plates, metapedes is licked as to pain reaction indicator using mouse, tests 3 times altogether, is no more than 30s person every time for qualification
Person is averaged as pain threshold before administration.Qualified mouse is equally divided into 4 groups：
A groups：Physiological saline, each 2mL are smeared in mouse metapedes；
B groups：The honey Chinese herbal medicine unguentum perniosis agent of raw control group 4, each 2g are smeared in mouse metapedes；
C groups：The commercially available section field board kibe ointment of raw control group 5, each 2g are smeared in mouse metapedes；
D groups：The raw honey Chinese herbal medicine unguentum perniosis agent to experimental group, each 2g are smeared in mouse metapedes；
Test three times, measures pain threshold after every minor tick 2h, last dose 0.5h, is compared, ties with pain threshold before administration altogether
Fruit is as shown in table 2：
Note：" * " is the significance of difference
By 2 experimental data of table it is found that compared with remaining is 3 groups, the administration priority pain threshold difference of D groups is the most notable, i.e., of the invention
The agent of gained honey Chinese herbal medicine unguentum perniosis has apparent analgesic effect, and Japanese raisintree fruit has been the key component of analgesic effect.
Claims (6)
1. a kind of honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：Include following component：
Natural component：Honey, raw milk；
Medicinal herb components：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima, three plumage crescent ferns
And Japanese raisintree fruit；
Other ingredients：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride；
Wherein, natural component:Traditional Chinese medicine ingredients:The weight ratio of other ingredients is 5:3:2.
2. honey Chinese herbal medicine unguentum perniosis agent according to claim 1, it is characterised in that：The honey:Raw milk
Weight ratio is 6:4.
3. honey Chinese herbal medicine unguentum perniosis agent according to claim 1, it is characterised in that：The glycerine:Palmitic acid is sweet
Grease:Sodium Hyaluronate:The mass ratio of sodium chloride is 4: 2 : 3 : 1.
4. honey Chinese herbal medicine unguentum perniosis agent according to claim 2, it is characterised in that：The traditional Chinese medicine ingredients are by weight
It weighs, respectively：15 ~ 40 parts of dalbergia wood, 23 ~ 50 parts of radix semiaquilegiae, 13 ~ 35 parts of Radix Ophiopogonis, 16 ~ 32 parts of insane eggplant, east mistletoe 15 ~ 31
Part, 20 ~ 35 parts of chinaroot greenbrier, 12 ~ 23 parts of red sage, 35 ~ 56 parts of ficus simplicissima, three 33 ~ 60 parts of plumage crescent ferns, 30 ~ 54 parts of Japanese raisintree fruit.
5. honey Chinese herbal medicine unguentum perniosis agent according to claim 4, it is characterised in that：The traditional Chinese medicine ingredients are by weight
It weighs, respectively：35 parts of dalbergia wood, 30 parts of radix semiaquilegiae, 20 parts of Radix Ophiopogonis, 25 parts of insane eggplant, 23 parts of east mistletoe, 28 parts of chinaroot greenbrier, one
Go here and there red 18 parts, 38 parts of ficus simplicissima, three 40 parts of plumage crescent ferns, 42 parts of Japanese raisintree fruit.
6. any one of the claim 1-5 honey Chinese herbal medicine unguentum perniosis agent, it is characterised in that：The honey Chinese herbal medicine pernio
The preparation method of ointment comprises the steps of：
（1）Honey is diluted with water, by adding water honey water content between 25 ~ 30%, agitating and heating, and 65 ~ 75 DEG C of heating temperature,
0.5 ~ 1h of heating time crosses 150 mesh sieve, obtains honey liquid juice；
（2）It weighs respectively by weight：Dalbergia wood, radix semiaquilegiae, Radix Ophiopogonis, insane eggplant, east mistletoe, chinaroot greenbrier, red sage, ficus simplicissima and
Three plumage crescent ferns, clean up after mixing, are 1g by solid-liquid ratio:The ratio of 20mL adds water, agitating and heating, heating temperature 85 ~ 95
DEG C, 1.5 ~ 2h of heating time crosses 200 mesh sieve, obtains the pure extracting solution of Chinese medicine；
（3）By step（2）The pure extracting solution of gained Chinese medicine and step（1）Gained honey liquid juice presses 2:3 volume ratio mixing
Uniformly, agitating and heating, 45 ~ 50 DEG C of heating temperature, heating time 0.5h obtain mixing liquid；
（4）Japanese raisintree fruit is weighed by weight, is cleaned up, by 1g:The ratio of 10mL admixes sea red fruit wine, is sealed 1 ~ 2 day
After take out, naturally dry, milling sieve with 100 mesh sieve, and obtain Japanese raisintree fruit powder；
（5）In step（3）It is sequentially added in gained mixing liquid：Glycerine, palmitic acid fat, Sodium Hyaluronate and sodium chloride,
Agitating and heating, 65 DEG C of heating temperature, 0.5 ~ 1h of heating time obtain mixture；
（6）In step（5）Step is added in gained mixture（4）Gained Japanese raisintree fruit powder and raw milk, agitating and heating, heating temperature
40 ~ 50 DEG C, 1.5 ~ 2h of heating time of degree, crosses 200 mesh sieve, concentration, control water content 5 ~ 10%, after sterilize, sterilising temp
85 DEG C, sterilization time 20min；It is cooled down after sterilizing, it is filling, obtain honey Chinese herbal medicine unguentum perniosis agent finished product.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316267B (en) * | 2013-07-13 | 2014-09-24 | 浙江新力塑料股份有限公司 | Externally applied traditional Chinese medicine for treating chilblain |
| CN104524078A (en) * | 2015-01-14 | 2015-04-22 | 黄琴 | Chilblain prevention medicine |
-
2018
- 2018-01-29 CN CN201810083371.9A patent/CN108159256A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316267B (en) * | 2013-07-13 | 2014-09-24 | 浙江新力塑料股份有限公司 | Externally applied traditional Chinese medicine for treating chilblain |
| CN104524078A (en) * | 2015-01-14 | 2015-04-22 | 黄琴 | Chilblain prevention medicine |
Non-Patent Citations (1)
| Title |
|---|
| 胡富魏等: "甘油蜂蜜混合液治疗冻疮的临床观察", 《现代护理》 * |
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Application publication date: 20180615 |