CN108157354A - Repair system is perfused in isolated organ - Google Patents
Repair system is perfused in isolated organ Download PDFInfo
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- CN108157354A CN108157354A CN201810242092.2A CN201810242092A CN108157354A CN 108157354 A CN108157354 A CN 108157354A CN 201810242092 A CN201810242092 A CN 201810242092A CN 108157354 A CN108157354 A CN 108157354A
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- subsystem
- pipeline
- isolated organ
- centrifugal pump
- perfusion
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Abstract
This application involves a kind of isolated organs to be perfused repair system, including：Container, the isolated organ are stored in the container；Pipeline cycle subsystem is connect with the lumen therethrough of the isolated organ；Centrifugal pump subsystem is penetrated through with the pipeline cycle subsystem and is connected, and liquid is repaired for being pumped into perfusion to the isolated organ；Control subsystem is connect respectively with the pipeline cycle subsystem and the centrifugal pump subsystem communication.It penetrates through and connects by using the blood vessel of the pipeline circulatory system and isolated organ, and it persistently pours into perfusion and repairs liquid, while to be preserved in the long-time for realizing isolated organ, such as histocyte is effectively avoided to be damaged, organ ischemia the problems such as, promote the success rate of transfer operation.
Description
Technical field
The present invention relates to medical assistance equipment technology fields, and system is perfused more particularly to a kind of isolated organ.
Background technology
When carrying out organ transplant, the preservation of organ can directly determine the success or failure of transfer operation.
At present, the method that low temperature static preservation is usually used carries out the preservation of isolated organ, i.e., reduces device by low temperature
Function consumes, to extend the holding time of organ.
But prolonged low temperature environment, histocyte can be caused to be damaged on isolated organ, organ ischemia etc. asks
Topic, so as to reduce the success rate of transfer operation.
Invention content
Based on this, it is necessary to provide a kind of isolated organ perfusion repair system, pass through pipeline and isolated organ (i.e. donor device
Official) blood vessel perforation connection, and persistently pour into perfusion and repair liquid etc., to realize that the long-time of isolated organ is protected under normal temperature environment
Deposit, so effectively such as histocyte caused by low temperature environment is avoided to be damaged, organ ischemia the problems such as, promoted transplanting hand
The success rate of art.
Repair system is perfused in a kind of isolated organ, can be applied to extend at normal temperatures such as in vitro for lung, in vitro for heart
The holding time of isolated organs is waited, and the operations such as functional assessment and organ reparation can be carried out to isolated organ, the system comprises：
Container, the isolated organ are stored in the container；
Pipeline cycle subsystem is connect with the lumen therethrough of the isolated organ；
Centrifugal pump subsystem is penetrated through with the pipeline cycle subsystem and is connected, for being pumped into perfusion to the isolated organ
Repair liquid；
Control subsystem is connect respectively with the pipeline cycle subsystem and the centrifugal pump subsystem communication；
Wherein, the control subsystem is used to acquire and show the pipeline cycle subsystem and the centrifugal pump subsystem
Operating parameter；And
The control subsystem is additionally operable to adjust the pipeline cycle subsystem and centrifugal pump according to manipulation instruction
The operating parameter of system.
Above-mentioned isolated organ perfusion repair system, by using the pipeline circulatory system and isolated organ (i.e. donor organ)
Lumen therethrough connection, and persistently pour into perfusion repair liquid, under normal temperature environment realize isolated organ when body state is long
Between preserve and transhipment, and then effectively such as histocyte caused by low temperature environment is avoided to be damaged, organ ischemia the problems such as；
Meanwhile the circulatory system of liquid formation is repaired by the perfusion that centrifugal pump subsystem is pumped into, it can effectively remove in isolated organ
Thrombus, inflammatory factor or other foreign matter harmful substances, and then the function vascular patency of isolated organ can be maintained, it is all so as to improve
Such as pulmonary edema improves cardiopulmonary oxygen conjunction ability, and can reduce early postoperation graft to carry out repairing and treating to isolated organ
Work(is lost, effectively promotes the utilization rate of donor organ and the success rate of transfer operation.
In an optional embodiment, the isolated organ is in vitro lungs, the system also includes：
Lung ventilator subsystem is penetrated through with the pipeline cycle subsystem and is connected, for providing oxygen to the isolated organ,
And carry out lung recruitment；
Wherein, the control subsystem is also communicated to connect with the breathing subsystem, for acquiring the breathing subsystem
Operating parameter and according to the manipulation instruction adjustment it is described breathing subsystem operating parameter.
In an optional embodiment, the control subsystem includes：
Slave computer device, respectively with the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem
System communication connection, for acquiring the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem respectively
Operating parameter；
Host computer device is connect with the slave computer device, for the operating parameter to be shown；
Wherein, the host computer device is additionally operable to receive manipulation instruction and issues adjusting parameter to the slave computer device,
To adjust the operating parameter of the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem respectively.
In an optional embodiment, the slave computer device includes pipeline loop control unit, lung ventilator control list
Member and centrifugation pump control unit；And
The host computer device includes pipeline loop parameter unit, ventilator parameter unit and centrifugal pump parameters unit；
Wherein, the pipeline loop control unit is used to acquire the operating parameter of the pipeline cycle subsystem and be uploaded to
The pipeline loop parameter unit is shown；The pipeline loop parameter unit is additionally operable to receive manipulation instruction and issues pipeline
Adjusting parameter is recycled to the pipeline loop control unit, to adjust the operating parameter of the pipeline cycle subsystem；
The lung ventilator control unit is used to acquire the operating parameter of the lung ventilator subsystem and is uploaded to the breathing
Machine parameters unit is shown；The ventilator parameter unit is additionally operable to receive manipulation instruction and issues lung ventilator adjusting parameter extremely
The lung ventilator control unit, to adjust the operating parameter of the lung ventilator subsystem；And
The centrifugation pump control unit is used to acquire the operating parameter of the centrifugal pump subsystem and is uploaded to the centrifugation
Pump parameters unit is shown；The centrifugal pump parameters unit is additionally operable to receive manipulation instruction and issues centrifugal pump adjusting parameter extremely
The centrifugation pump control unit, to adjust the operating parameter of the centrifugal pump subsystem.
In an optional embodiment, the lung ventilator subsystem includes lung ventilator control element, driving device, breathing
Machine ontology, humidification machine, atomizer and gas piping；
Wherein, the lung ventilator control element controls the operating parameter of the lung ventilator ontology by the driving device；
The lung ventilator ontology passes sequentially through the humidification machine, the atomizer and the gas piping and is connect with the isolated organ,
For the oxygen after humidifying and atomization to be supplied to the isolated organ
In an optional embodiment, the pipeline cycle subsystem includes constant temperature unit and transmission unit；
Wherein, the transmission unit connects respectively with the centrifugal pump subsystem and isolated organ perforation, for inciting somebody to action
The perfusion of the centrifugal pump subsystem output repairs liquid and is sent to the isolated organ；And
The perfusion that the constant temperature unit is used to that the centrifugal pump subsystem to be kept to be transmitted repairs the temperature of liquid scheduled
In temperature range.
In an optional embodiment, the transmission unit includes perfusion and repairs between liquid pipeline, connection arteriovenous
Bridge tube, fluid reservoir, gas-exchange membrane gas-exchange membrane, mixing device of air, tracheae pipeline, filter and bridge tube；
Wherein, the fluid reservoir is connect with the centrifugal pump subsystem, which is also repaiied by the perfusion
Multiple liquid pipeline is connect with the gas-exchange membrane, enters the gas friendship for the perfusion in the fluid reservoir to be repaired liquid pump
Change film；The mixing device of air is connect by the tracheae pipeline with the gas-exchange membrane, for the gas-exchange membrane
The mixed gas of liquid progress gas exchanges is repaired in middle input with the perfusion；And
The gas-exchange membrane passes sequentially through the filter and the bridge tube is connected to the arterial of the isolated organ
Chamber, for the perfusion reparation liquid after gas exchanges to be filtered and is perfused into the isolated organ, and the isolated organ
The perfusion is repaired liquid by vein tube chamber to be back in the fluid reservoir.
In embodiment, when repairing liquid by the perfusion that centrifugal pump subsystem is pumped into, moreover it is possible to further be gone by pass filter
Except thrombus, inflammatory factor or other harmful substances in isolated organ, and then the function of isolated organ can be maintained, so as into one
Step improves pulmonary edema, improves cardiopulmonary oxygen conjunction ability, and can carry out repairing and treating to isolated organ, reduces early postoperation graft
Work(is lost, effectively promotes the utilization rate of donor organ and the success rate of transfer operation.
In an optional embodiment, the constant temperature unit includes heating and cooling water tank, lifting temperature control circuit, water tank
Circulation line；
Wherein, the lifting temperature control circuit is used to control the temperature of the water in the heating and cooling water tank；The water tank
Circulation line is connected to the water outlet and water return outlet of the heating and cooling water tank, for by the constant temperature in the heating and cooling water tank
Water introduces to repair after liquid carries out heat exchange with the perfusion in the gas-exchange membrane leads back the heating and cooling water tank again.
In an optional embodiment, the pipeline cycle subsystem further includes pressure sensor and flow sensor；
Wherein, the pressure sensor is respectively arranged at the vein of the isolated organ and transmission unit perforation connects
Pipeline on, on the pipeline that is connect with the transmission unit of the artery of isolated organ, the flow sensor be set to it is described from
In the pipeline that the artery of body organ is connected with transmission unit perforation.
In an optional embodiment, the centrifugal pump subsystem includes centrifugation pump head, centrifugal pump motor and centrifugal pump
Circuit for controlling motor；
Wherein, the centrifugal pump motor control circuit controls the operation of the centrifugal pump motor, which passes through
The perfusion is repaired liquid pump and enters the pipeline cycle subsystem by the centrifugation pump head.
In an optional embodiment, above-mentioned isolated organ perfusion system may also include：
Server is communicated to connect with the control subsystem, for storing the operating parameter；
Mobile monitoring device communicates to connect respectively with the server and the control subsystem；
Wherein, different isolated organs perfusion system shares the same server.
In an optional embodiment, the control subsystem may also include：
Warning device is connect with the mobile monitoring device, to institute during judging that the operating parameter exceeds preset value
It states mobile monitoring device and sends warning message；
Wherein, the mobile monitoring device is additionally operable to send manipulation instruction to the control subsystem, to adjust the pipe
The operating parameter of road cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem.
Isolated organ perfusion system in the embodiment of the present application can be convenient for monitoring in vitro device by using mobile monitoring device
The preservation state of official is monitored into without specially accrediting operating personnel in control, so as to be effectively saved human cost；Together
When, the real time information that different isolated organ perfusion systems is acquired timely is uploaded in unified server, convenient for device
The inquiry and storage of historical data is perfused in official, conducive to big data analysis and processing is carried out.
Description of the drawings
Fig. 1 is the structure diagram that repair system is perfused in isolated organ in one embodiment；
Fig. 2 is the structure diagram for supplying lung perfusion repair system in one embodiment in vitro；
Fig. 3 is the structure diagram of control subsystem in Fig. 2；
Fig. 4 is the structure diagram of host computer device and slave computer device in Fig. 3；
Fig. 5 is the structure diagram of lung ventilator subsystem in Fig. 2；
Fig. 6 is the structure diagram of pipeline cycle subsystem in Fig. 1 and Fig. 2；
Fig. 7 is the structure diagram of transmission unit in Fig. 6；
Fig. 8 is the structure diagram of constant temperature unit in Fig. 6；
Fig. 9 is the structure diagram of pipeline cycle subsystem in another embodiment；
Figure 10 is the structure diagram of centrifugal pump subsystem in Fig. 1 and Fig. 2.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Fig. 1 is the structure diagram that repair system is perfused in isolated organ in one embodiment.It is as shown in Figure 1, a kind of in vitro
Organ perfusion's repair system, can be applied under room temperature (i.e. in the range of the normal body temperature of human body) extend it is such as in vitro for lung,
It the in vitro holding time for isolated organs 2 such as hearts, simultaneously can be used for repairing isolated organ 2 and the behaviour such as functional assessment
Make；The system may include container 1, pipeline cycle subsystem 3, centrifugal pump subsystem 4, control subsystem 5, server 6 and movement
Monitoring device 7.Container 1 can be the structure of sealing, for holding above-mentioned isolated organ 2, and for the stabilization of hoisting container 1
Property, the container 1 can also be placed in container fixed frame, to ensure in the operation subsequently carried out so that isolated organ 2 is in phase
To in stable environment.Pipeline cycle subsystem 3 can be connected with the arterial lumen (such as pulmonary artery) and vein official jargon of isolated organ 2
Connection, centrifugal pump subsystem 4 can then lead to 3 Bidirectional tubular of pipeline cycle subsystem to be connect, and is repaired with providing perfusion to isolated organ 2
Liquid, while also form the circulating pipe system that liquid is repaired in perfusion；I.e. above-mentioned isolated organ 2 is placed on the interior of the container 1 of sealing
Portion, perfusion repair the artery that liquid is pumped into isolated organ 2 by centrifugal pump subsystem 4 by pipeline cycle subsystem 3, and in vitro through this
The vein centrifugal pump subsystem 4 of organ 2 is back to again in centrifugal pump subsystem, and then forms the pipe-line system of cycle.Control
Subsystem 5 can then be communicated to connect with pipeline cycle subsystem 3 and centrifugal pump subsystem 4 respectively, i.e., the control subsystem 5 can be used
In acquiring and show the operating parameter of above-mentioned pipeline cycle subsystem 3 and the operating parameter of centrifugal pump subsystem 5, and control
System 5 can also adjust the operating parameter centrifugal pump subsystem 5 of above-mentioned pipeline cycle subsystem 3 according to the manipulation instruction received
The operations such as operating parameter.
Fig. 2 is the structure diagram for supplying lung perfusion repair system in one embodiment in vitro.As shown in Fig. 2, in vitro
When being irrigated preservation for the isolated organ that lung needs oxygen to supply, above-mentioned isolated organ perfusion repair system, which may also include, exhales
Loom system 8 is inhaled, which can penetrate through with pipeline cycle subsystem 3 and connect to provide oxygen to isolated organ 2,
And carry out lung recruitment.Meanwhile above-mentioned control subsystem 5 can also be communicated to connect with the lung ventilator subsystem 8, for acquiring simultaneously
Show the operating parameter of the lung ventilator subsystem 8, and the control subsystem 5 can also be adjusted according to the manipulation instruction of the reception
The operating parameter of above-mentioned lung ventilator subsystem 8.Wherein, above-mentioned pipeline cycle subsystem 3, lung ventilator subsystem 8 and centrifugal pump
4 grade subsystems of subsystem can be the modular structure of Highgrade integration, to save system cost and occupied space.
In addition, as shown in Fig. 2, above-mentioned server 6 can be communicated to connect with control subsystem 5, and the server 6 may include
Data store and processing unit, the above-mentioned operation ginseng acquired for storage control subsystem 5 (i.e. slave computer device 51)
The operation ginseng of number, the i.e. operating parameter of pipeline cycle subsystem 3, the operating parameter of lung ventilator subsystem 8 and centrifugal pump subsystem 5
Number etc., storage and analyzing and processing in order to historical data.Wherein, above-mentioned server 6 can be cloud server, in order to right
The operating parameter of different system carries out cloud storage, ensure data it is safe while, may also be combined with big data analysis technology, it is right
The monitoring data of storage isolated organ 2 is analyzed and processed, and then realizes and the preservation situation of isolated organ 2 is predicted, is prevented
Only isolated organ 2 occurs abnormal when stored.
Further, as shown in Fig. 2, based on above-mentioned cloud data storage technology, it may also be combined with medical big data analysis, one
A server 6 can be corresponded to corresponds to multiple isolated organs 2, and every using the isolated organ perfusion repair system in the embodiment of the present application
A isolated organ 2 is corresponding with corresponding account and password, in order to can be achieved with corresponding in vitro device by account and password
The operations such as the inquiry and analysis of the current monitoring data of official 2 and history monitoring data.
Further, as shown in Fig. 2, mobile monitoring device 7 then can respectively with above-mentioned server 6 and control subsystem 5
Communication connection, for inquiring current perfusion parameters by the control subsystem in real time, such as the operation of pipeline cycle subsystem 3
Operating parameter of parameter, the operating parameter of lung ventilator subsystem 8 and centrifugal pump subsystem 4 etc. can also be inquired in server 6 and be stored
Subsystems history perfusion parameters, while can also the control be passed through according to the warning message that control subsystem 5 is triggered
Subsystem 5 changes the operating parameter of current subsystems, and then realizes remote, the real time monitoring to isolated organ 2, in side
Just, it can be achieved that comprehensively being monitored and controlled to perfusion, effectively to ensure isolated organ 2 while staff is monitored
It is constantly in preset environment, further to extend the holding time of isolated organ 2.
Further, different isolated organs perfusion repair system can share same server 6, in order to perfusion parameters
The storage and inquiry of data, while big data analysis and processing can be also convenient for, to promote isolated organ perfusion repair system
Compatibility between institute's environment construction and isolated organ 2 further promotes the holding time of isolated organ 2, and can be quick and precisely
The ground state current to isolated organ 2 carries out perfect assessment.
It can be integrated into one again by using the subsystems of high integration, and by the subsystems in the present embodiment
Body structure not only improves the integrated level of entire perfusion repair system, also causes the more lighting of whole system equipment, and operate
It is simple and convenient.
Fig. 3 is the structure diagram of control subsystem in Fig. 2.As Figure 2-3, on the basis of based on structure shown in Fig. 2,
Above-mentioned control subsystem 5 may include slave computer device 51 and host computer device 52；The slave computer device 51 can respectively with it is above-mentioned
Pipeline cycle subsystem 3, lung ventilator subsystem 8 and centrifugal pump subsystem 4 communicate to connect, available for acquiring such as pipeline respectively
The operating parameter of the subsystems such as cycle subsystem 3, lung ventilator subsystem 8 and centrifugal pump subsystem 4；Host computer device 52 is then
It can be connect with above-mentioned 51 interactive type communication of slave computer device, for receiving the operating parameter that slave computer device 51 is acquired,
And shown the operating parameter by display devices such as display screen, projections, so as to fulfill by above-mentioned each subsystem
The operating parameter of system carries out centralized displaying, not only realizes the overall monitor of the preservation condition to current isolated organ 2, simultaneously also
Further improve the convenience of monitoring.
Further, as Figure 2-3, the operating parameter of above-mentioned pipeline cycle subsystem 3 may include that liquid stream is repaired in perfusion
Amount, perfusion repair liquid temperature, perfusion vein pressure, perfusion arterial pressure, pipeline bubble parameter and relative parameters setting instruction letter
Breath etc.；The operating parameter of above-mentioned lung ventilator subsystem 8 may include tidal volume, respiratory rate, inspiratory duration, inspiratory/expiratory, oxygen concentration,
Pressure and relative parameters setting instruction etc.；The operating parameter of above-mentioned centrifugal pump subsystem 4 may include centrifuging revolution speed and related ginseng
Number setting instruction etc..
Meanwhile as Figure 2-3, above-mentioned host computer device 52 can also be used to join above-mentioned operating parameter as perfusion
A several parts is uploaded to server 6 and is stored.Certainly, which also can be by downloading accordingly from server 6
Operating parameter by slave computer device 51 to above-mentioned such as pipeline cycle subsystem 3, lung ventilator subsystem 8 and centrifugal pump
System 4 etc. is reset.Wherein, above-mentioned host computer device 52 also can issue adjusting parameter according to the manipulation instruction received
To slave computer device 51, to adjust above-mentioned pipeline cycle subsystem 3, lung ventilator subsystem 8 respectively by the slave computer device 51
With the operating parameter of 4 grade of centrifugal pump subsystem, and then realize the Conservation environment in container 1 is adjusted, to promote in vitro device
The holding time of official 2.
Fig. 4 is the structure diagram of host computer device and slave computer device in Fig. 3.As in Figure 2-4, above-mentioned slave computer
Device 51 may include pipeline loop control unit 511, centrifuge pump control unit 512 and lung ventilator control unit 513, and host computer
Device 52 then may include pipeline loop parameter unit 521, centrifugal pump parameters unit 522 and ventilator parameter unit 523.Wherein,
Above-mentioned pipeline loop control unit 511 is connect respectively with pipeline loop parameter unit 521 and management cycle subsystem 3, can be used
In the operating parameter of acquisition pipeline cycle subsystem 3 in real time, and the operating parameter of collected pipeline cycle subsystem 3 is uploaded
It is shown to pipeline loop parameter unit 521, and the pipeline loop parameter unit 521 can be additionally used according to the manipulation received
Instruction issues pipeline and recycles adjusting parameter to pipeline loop control unit 511, to be adjusted by the pipeline loop control unit 511
The current operating parameter of pipeline cycle subsystem 3；Above-mentioned centrifugation pump control unit 512 respectively with centrifugal pump parameters unit 522
It is connected with centrifugal pump subsystem 4, for acquiring the operating parameter (such as rotating speed of centrifugal pump etc.) of centrifugal pump subsystem 4, and
By the operating parameter of collected centrifugal pump subsystem 4 be uploaded to centrifugal pump parameters unit 522 and shown, and the centrifugal pump
The manipulation instruction that parameters unit 522 can be additionally used in received by root issues centrifugal pump adjusting parameter and extremely centrifuges pump control unit 512,
To adjust the current operating parameter of centrifugal pump subsystem 4 by the centrifugation pump control unit 512；Above-mentioned lung ventilator control unit
513 connect respectively with ventilator parameter unit 523 and lung ventilator subsystem 8, available for acquiring the operation ginseng of lung ventilator subsystem 8
Number, and by the operating parameter of collected lung ventilator subsystem 8 be uploaded to ventilator parameter unit 523 and shown, and be somebody's turn to do
Ventilator parameter unit 523 can also be used to issue lung ventilator adjusting parameter to lung ventilator control according to received manipulation instruction
Unit 513, to adjust the current operating parameter of lung ventilator subsystem 8 by the lung ventilator control unit 513.
As shown in Figs 1-4, in an optional embodiment, control subsystem 5 may also include to be connected with mobile monitoring device 7
The warning device (not shown) connect, to judge, whether collected operating parameter exceeds preset value, and beyond pre-
If sending warning message to the mobile monitoring device 7 during value, such relevant staff just monitors without stationary point, by above-mentioned
The preservation state that isolated organ 2 can be realized in mobile monitoring device 7 carries out remote monitoring.Wherein, mobile monitoring device 7 also can be used
In sending manipulation instruction to control subsystem 5, to adjust above-mentioned pipeline cycle subsystem 3, lung ventilator subsystem 8 and centrifugal pump
The operating parameter of 4 grade subsystems of system.
Fig. 5 is the structure diagram of lung ventilator subsystem in Fig. 2.As shown in Figure 2-5, in embodiments herein, breathing
Loom system 8 may include that lung ventilator control element 81, driving device 82, lung ventilator ontology 83, humidification machine 84, atomizer 85 are gentle
86 grade components of body pipeline.Above-mentioned lung ventilator control element 81 can control the operation of lung ventilator ontology 83 to join by driving device 82
Number, and lung ventilator ontology 83 can then be connect by humidification machine 84 and atomizer 85 with gas piping 86, for by humidifying and mist
Oxygen after change is supplied to isolated organ 2, to extend the holding time of isolated organ 2.Meanwhile above-mentioned control subsystem 5 can
It adjusts the operating status of lung ventilator ontology by lung ventilator control element 81 and directly controls such as humidification machine 84 and atomization
The operation of 85 grade components of device, and humidification machine 84, atomizer 85 and lung ventilator control element 81 can also be incited somebody to action by some sensing devices
Corresponding operating parameter feeds back to the control subsystem.
Fig. 6 is the structure diagram of pipeline cycle subsystem in Fig. 1 and Fig. 2.As shown in figures 1 to 6, it is optional real at one
It applies in example, above-mentioned pipeline cycle subsystem 3 may include transmission unit 31 and constant temperature unit 32；Transmission unit 31 can respectively with centrifugation
Pump subsystem 4 and the perforation connection of isolated organ 2, for the perfusion that is exported centrifugal pump subsystem 4 repair liquid be sent to from
Body organ 2, and constant temperature unit 32 then can be used for the perfusion that centrifugal pump subsystem 4 is kept to be transmitted to repair the temperature of liquid scheduled
In temperature range, that is, perfusion is kept to repair constant temperature of the liquid in certain temperature range so that perfusion repair the temperature of liquid with from
Body organ 2 matches.
Fig. 7 is the structure diagram of transmission unit in Fig. 6.As shown in figs. 1-7, above-mentioned transmission unit 31 may include being perfused
Repair liquid pipeline 311, fluid reservoir 317, gas-exchange membrane gas-exchange membrane 312, mixing device of air 313, tracheae pipeline 314, mistake
The components such as bridge tube 316 and fluid reservoir 317 between filter 315, connection arteriovenous.Fluid reservoir 317 by centrifugal pump subsystem 4 with
The perforation connection of liquid pipeline 311 is repaired in perfusion, and the perfusion repairs liquid pipeline 311 and also passes sequentially through gas-exchange membrane 312, filter
315 and the arterial lumen perforation of bridge tube 316 and isolated organ 2 connect, and mix device of air 313 and connected by tracheae pipeline 314
To gas-exchange membrane 312, isolated organ 2 is connect by vein with fluid reservoir 317, and then forms the circulation line that liquid is repaired in perfusion
System.I.e. the perfusion stored in fluid reservoir 317 reparation liquid pump is entered gas by centrifugal pump subsystem 4 by perfusion reparation liquid pipeline 311
In body exchange membrane 312, and mix device of air 313 and mixed gas is inputted into gas-exchange membrane 312 by tracheae pipeline 314, with
Liquid is repaired to the perfusion in gas-exchange membrane 312 and carries out gas exchanges；Filter 315 repaiies the perfusion after carrying out gas exchanges
After multiple liquid is filtered, it will be perfused and repaired in perfusion to the artery of isolated organ 317 by bridge tube 316, and the isolated organ
Perfusion is repaired liquid by 317 again by vein to be back in fluid reservoir 317, so as to form the circulation line system that liquid is repaired in a perfusion
System.
Fig. 8 is the structure diagram of constant temperature unit in Fig. 6.As shown in figures 1-8, above-mentioned constant temperature unit 32 then may include rising
Cooling control circuit 321, heating and cooling water tank 322 and water tank circulation line 323 lift temperature control circuit 321 and can be used for controlling
The temperature of water in heating and cooling water tank 322 processed, and water tank circulation line 323 is then connected to the water outlet of heating and cooling water tank 322
Mouthful and water return outlet, for by the thermostatted water (being maintained at the water in preset temperature range) in heating and cooling water tank 322 by going out
The mouth of a river introduce pattern oxygenator in 312 li, and in the gas-exchange membrane 312 perfusion repair liquid carry out heat exchange after, through upper
The water return outlet stated is led back again in heating and cooling water tank 322, to keep being perfused the temperature of reparation liquid and isolated organ 2 mutually suitable.
Fig. 9 is the structure diagram of pipeline cycle subsystem in another embodiment.In another optional embodiment,
As shown in figure 9, above-mentioned pipeline cycle subsystem 3 may also include pressure sensor 33 and flow sensor 34, the pressure sensing
Device 33 may be disposed on the artery of transmission unit 31 and isolated organ 2 and the pipeline of vein perforation connection, can also set according to demand
It puts at the positions such as the bottom of container 1, the current pressure value of liquid is repaired for acquiring perfusion in perfusion system pipeline in real time；Stream
Quantity sensor 34 then may be disposed in the artery of isolated organ 2 and the pipeline of the perforation connection of transmission unit 31, for adopting in real time
The current flow of liquid is repaired in perfusion in collection perfusion repair system pipeline.Certainly, it in practical application, can also set according to demand
Other sensing elements are put, for acquiring required other parameter in perfusion system pipeline in real time.
Figure 10 is the structure diagram of centrifugal pump subsystem in Fig. 1 and Fig. 2.As Figure 1-10 shows, it is optional real at one
It applies in example, above-mentioned centrifugal pump subsystem 4 includes such as centrifugal pump motor control circuit 41, from centrifugal pump motor 42 and centrifugal pump
First 43 grade components, the centrifugal pump motor control circuit 41 can control the operation of centrifugal pump motor 42, which passes through
Centrifugation pump head 43 will be perfused reparation liquid pump and enter pipeline cycle subsystem 3.Meanwhile above-mentioned control system 5 can pass through centrifugal pump electricity
Machine control circuit 41 adjusts the operating parameter of centrifugal pump motor 42, and can also be by the centrifugal pump electricity of acquisition by some sensing equipments
In the current operating parameter Real-time Feedback to control subsystem 5 of machine 42.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (12)
1. repair system is perfused in a kind of isolated organ, which is characterized in that the system comprises：
Container, the isolated organ are stored in the container；
Pipeline cycle subsystem is connect with the lumen therethrough of the isolated organ；
Centrifugal pump subsystem is penetrated through with the pipeline cycle subsystem and is connected, and is repaired for being pumped into perfusion to the isolated organ
Liquid；
Control subsystem is connect respectively with the pipeline cycle subsystem and the centrifugal pump subsystem communication；
Wherein, the control subsystem is used to acquiring and showing the pipeline cycle subsystem and the fortune of the centrifugal pump subsystem
Row parameter；And the control subsystem is additionally operable to adjust the pipeline cycle subsystem and the centrifugal pump according to manipulation instruction
The operating parameter of subsystem.
2. repair system is perfused in isolated organ as described in claim 1, which is characterized in that the isolated organ is Isolated-lung
It is dirty, the system also includes：
Lung ventilator subsystem is penetrated through with the pipeline cycle subsystem and is connected, and for providing oxygen to the isolated organ, is gone forward side by side
Row lung recruitment；
Wherein, the control subsystem is also communicated to connect with the breathing subsystem, for acquiring the fortune of the breathing subsystem
Row parameter and the operating parameter according to the manipulation instruction adjustment breathing subsystem.
3. repair system is perfused in isolated organ as claimed in claim 2, which is characterized in that the control subsystem includes：
Slave computer device leads to respectively with the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem
Letter connection, for acquiring the fortune of the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem respectively
Row parameter；
Host computer device is connect with the slave computer device, for the operating parameter to be shown；
Wherein, the host computer device is additionally operable to receive manipulation instruction and issues adjusting parameter to the slave computer device, to
The operating parameter of the pipeline cycle subsystem, the lung ventilator subsystem and the centrifugal pump subsystem is adjusted respectively.
4. repair system is perfused in isolated organ as claimed in claim 3, which is characterized in that the slave computer device includes pipeline
Loop control unit, lung ventilator control unit and centrifugation pump control unit；And
The host computer device includes pipeline loop parameter unit, ventilator parameter unit and centrifugal pump parameters unit；
Wherein, the pipeline loop control unit is used to acquire the operating parameter of the pipeline cycle subsystem and be uploaded to described
Pipeline loop parameter unit is shown；The pipeline loop parameter unit is additionally operable to receive manipulation instruction and issues pipeline cycle
Adjusting parameter is to the pipeline loop control unit, to adjust the operating parameter of the pipeline cycle subsystem；
The lung ventilator control unit is used to acquire the operating parameter of the lung ventilator subsystem and is uploaded to the lung ventilator ginseng
Counting unit is shown；The ventilator parameter unit is additionally operable to receive manipulation instruction and issues lung ventilator adjusting parameter to described
Lung ventilator control unit, to adjust the operating parameter of the lung ventilator subsystem；And
The centrifugation pump control unit is used to acquire the operating parameter of the centrifugal pump subsystem and is uploaded to the centrifugal pump ginseng
Counting unit is shown；The centrifugal pump parameters unit is additionally operable to receive manipulation instruction and issues centrifugal pump adjusting parameter to described
Pump control unit is centrifuged, to adjust the operating parameter of the centrifugal pump subsystem.
5. repair system is perfused in isolated organ as claimed in claim 2, which is characterized in that the lung ventilator subsystem includes exhaling
Suction machine control element, driving device, lung ventilator ontology, humidification machine, atomizer and gas piping；
Wherein, the lung ventilator control element controls the operating parameter of the lung ventilator ontology by the driving device；It is described
Lung ventilator ontology passes sequentially through the humidification machine, the atomizer and the gas piping and the tracheae of the isolated organ connects
It connects, for the oxygen after humidifying and atomization to be supplied to the isolated organ.
6. repair system is perfused in isolated organ as described in claim 1, which is characterized in that the pipeline cycle subsystem includes
Constant temperature unit and transmission unit；
Wherein, the transmission unit connects respectively with the centrifugal pump subsystem and isolated organ perforation, for by described in
The perfusion of centrifugal pump subsystem output repairs liquid and is sent to the isolated organ；And
The perfusion that the constant temperature unit is used to that the centrifugal pump subsystem to be kept to be transmitted repairs the temperature of liquid in scheduled temperature
In the range of.
7. repair system is perfused in isolated organ as claimed in claim 6, which is characterized in that the transmission unit includes perfusion and repaiies
Bridge tube, fluid reservoir, gas-exchange membrane, mixing device of air, tracheae pipeline, filter between multiple liquid pipeline, connection arteriovenous and
Bridge tube；
Wherein, the fluid reservoir is connect with the centrifugal pump subsystem, which also repairs liquid by the perfusion
Pipeline is connect with the gas-exchange membrane, enters the gas exchanges for the perfusion in the fluid reservoir to be repaired liquid pump
Film；The mixing device of air is connect by the tracheae pipeline with the gas-exchange membrane, for into the gas-exchange membrane
The mixed gas of liquid progress gas exchanges is repaired in input with the perfusion；And
The gas-exchange membrane passes sequentially through the filter and the bridge tube is connected to the arterial lumen of the isolated organ, uses
Be filtered and be perfused into the isolated organ in repairing liquid to the perfusion after gas exchanges, and the isolated organ pass through it is quiet
The perfusion is repaired liquid and is back in the fluid reservoir by vessel lumen.
8. repair system is perfused in isolated organ as claimed in claim 7, which is characterized in that the constant temperature unit includes heating and cooling
Water tank, lifting temperature control circuit, water tank circulation line；
Wherein, the lifting temperature control circuit is used to control the temperature of the water in the heating and cooling water tank；The water tank cycle
Pipeline is connected to the water outlet and water return outlet of the heating and cooling water tank, for the thermostatted water in the heating and cooling water tank to be drawn
Enter to repair after liquid carries out heat exchange with the perfusion in the gas-exchange membrane and lead back the heating and cooling water tank again.
9. repair system is perfused in isolated organ as claimed in claim 6, which is characterized in that the pipeline cycle subsystem is also wrapped
Include pressure sensor and flow sensor；
Wherein, the pressure sensor is respectively arranged at the vein of the isolated organ and the pipe of transmission unit perforation connection
On the road, on the pipeline that the artery of the isolated organ is connected with the transmission, the flow sensor is set to the in vitro device
In the pipeline that the artery of official is connected with transmission unit perforation.
10. repair system is perfused in isolated organ as described in claim 1, which is characterized in that the centrifugal pump subsystem includes
Centrifuge pump head, centrifugal pump motor and centrifugal pump motor control circuit；
Wherein, the centrifugal pump motor control circuit controls the operation of the centrifugal pump motor, which passes through described
The perfusion is repaired liquid pump and enters the pipeline cycle subsystem by centrifugation pump head.
11. repair system is perfused in isolated organ as described in claim 1, which is characterized in that further includes：
Server is communicated to connect with the control subsystem, for storing the operating parameter；
Mobile monitoring device communicates to connect respectively with the server and the control subsystem；
Wherein, different isolated organs perfusion system shares the same server.
12. repair system is perfused in isolated organ as claimed in claim 11, which is characterized in that the control subsystem includes：
Warning device is connect with the mobile monitoring device, to the shifting during judging that the operating parameter exceeds preset value
Dynamic monitoring device sends warning message；
Wherein, the mobile monitoring device is additionally operable to send manipulation instruction to the control subsystem, is followed with adjusting the pipeline
The operating parameter of loop subsystems and the centrifugal pump subsystem.
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| CN201810242092.2A CN108157354A (en) | 2018-03-22 | 2018-03-22 | Repair system is perfused in isolated organ |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN110463690A (en) * | 2019-08-26 | 2019-11-19 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ device for casting |
| CN110506734A (en) * | 2019-08-26 | 2019-11-29 | 陈静瑜 | Isolated organ perfusion equipment |
| CN110558310A (en) * | 2019-08-26 | 2019-12-13 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | isolated organ perfusion liquid-changing system |
| CN110583621A (en) * | 2019-08-26 | 2019-12-20 | 无锡市人民医院 | In-vitro lung mechanical perfusion control system, method and device |
| CN110692623A (en) * | 2019-08-26 | 2020-01-17 | 陈静瑜 | Isolated organ perfusion filtration system |
| CN112106766A (en) * | 2020-11-18 | 2020-12-22 | 中山大学附属第一医院 | Combined perfusion system and perfusion method for isolated heart and lung |
| WO2021036742A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo organ perfusion apparatus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540911A (en) * | 1985-11-22 | 1996-07-30 | Bio-Technology General Corp. | Methods of use of human manganese superoxide dismutase |
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
| CN107183005A (en) * | 2016-05-09 | 2017-09-22 | 多伦多Xor-Labs股份有限公司 | The apparatus and method for of organ perfusion |
-
2018
- 2018-03-22 CN CN201810242092.2A patent/CN108157354A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540911A (en) * | 1985-11-22 | 1996-07-30 | Bio-Technology General Corp. | Methods of use of human manganese superoxide dismutase |
| CN107183005A (en) * | 2016-05-09 | 2017-09-22 | 多伦多Xor-Labs股份有限公司 | The apparatus and method for of organ perfusion |
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN110463690A (en) * | 2019-08-26 | 2019-11-19 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ device for casting |
| CN110506734A (en) * | 2019-08-26 | 2019-11-29 | 陈静瑜 | Isolated organ perfusion equipment |
| CN110558310A (en) * | 2019-08-26 | 2019-12-13 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | isolated organ perfusion liquid-changing system |
| CN110583621A (en) * | 2019-08-26 | 2019-12-20 | 无锡市人民医院 | In-vitro lung mechanical perfusion control system, method and device |
| CN110692623A (en) * | 2019-08-26 | 2020-01-17 | 陈静瑜 | Isolated organ perfusion filtration system |
| WO2021036742A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo organ perfusion apparatus |
| WO2021036523A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo lung mechanical perfusion control system, method and apparatus |
| CN112106766A (en) * | 2020-11-18 | 2020-12-22 | 中山大学附属第一医院 | Combined perfusion system and perfusion method for isolated heart and lung |
| CN112106766B (en) * | 2020-11-18 | 2021-03-12 | 中山大学附属第一医院 | Combined perfusion system and perfusion method for isolated heart and lung |
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