WO2021036523A1

WO2021036523A1 - Ex vivo lung mechanical perfusion control system, method and apparatus

Info

Publication number: WO2021036523A1
Application number: PCT/CN2020/100792
Authority: WO
Inventors: 陈静瑜; 卢艳; 刘峰; 胡艳; 卫栋; 魏晓磊; 张勃; 唐均匀; 区焕财; 林祥华; 袁景泉; 周鹏; 王瑞彬; 杨振坤; 王伟
Original assignee: 无锡市人民医院; 广东顺德工业设计研究院(广东顺德创新设计研究院)
Priority date: 2019-08-26
Filing date: 2020-07-08
Publication date: 2021-03-04
Also published as: CN110583621A

Abstract

The present application relates to an ex vivo lung mechanical perfusion control system, method and apparatus. The ex vivo lung mechanical perfusion control system comprises a pipeline circulation apparatus, a power pump device, a flow sensor and a main control device. When receiving a constant-speed operation instruction, the main control device drives the power pump device according to constant rotation speed data corresponding to the constant-speed operation instruction; when receiving a constant flow operation instruction, the main control device acquires, according to the constant flow operation instruction, a flow collected by the flow sensor, and performs digital filtering processing on the flow to obtain the filtered flow; and the main control device performs PID adjustment processing on the filtered flow and a target flow to obtain a processing result, and adjusts the rotation speed of the power pump device according to the processing result. The present application can realize a plurality of perfusion modes of a constant-pump speed mode and a constant-flow speed mode, and each mode can be switched in an easy manner; and by performing data filtering processing and PID adjustment processing on flow data, the present application improves the accuracy of mechanical perfusion control for an ex vivo lung.

Description

Isolated lung mechanical perfusion control system, method and device

Technical field

This application relates to the technical field of mechanical perfusion, in particular to a mechanical perfusion control system, method and device for isolated lungs.

Background technique

Mechanical perfusion is a way to preserve and transport organs (such as isolated lungs). After the organ is harvested, its own blood vessels are connected to the organ mechanical perfusion system. The system continuously injects the perfusate into the isolated organs during the organ preservation and transport stage. At the same time, it supplies oxygen and nutrients to the isolated organs. In the process of mechanical perfusion of the isolated lung, the accuracy of controlling the perfusion parameters directly affects the quality of the isolated lung.

In the implementation process, the inventor found that the traditional technology has at least the following problems: the traditional lung perfusion system has a single control method and low perfusion accuracy.

Summary of the invention

Based on this, it is necessary to provide an isolated lung mechanical perfusion control system, method, and device in response to the single control mode and low perfusion accuracy of the traditional lung perfusion system.

In order to achieve the foregoing objective, an embodiment of the present invention provides an isolated lung mechanical perfusion control system, including:

The pipeline circulation device, which is used to connect with the pulmonary artery of the isolated lung;

Power pump equipment, the power pump equipment is used to drive the pipeline circulation device to transmit the perfusate to the pulmonary artery of the isolated lung; one end of the power pump device is connected to the pulmonary vein of the isolated lung, and the other end is connected to the pipeline circulation device;

Flow sensor, the flow sensor is used to collect the flow of the perfusion liquid; the flow sensor is set between the power pump equipment and the pipeline circulation device;

Main control equipment, which is connected to power pump equipment and flow sensor respectively;

Among them, when the master control device receives the constant speed operation instruction, it drives the power pump device according to the constant speed data corresponding to the constant speed operation instruction;

When the master control device receives the constant current operation instruction, it obtains the flow collected by the flow sensor according to the constant current operation instruction, and performs digital filtering processing on the flow to obtain the filtered flow; the master control device compares the filtered flow with the target flow Perform PID adjustment processing to obtain the processing result, and adjust the speed of the power pump equipment according to the processing result.

In one of the embodiments, it further includes a first pressure sensor provided between the pulmonary vein of the isolated lung and the power pump device; the first pressure sensor is connected to the main control device;

Wherein, the first pressure sensor collects the venous end pressure of the perfusion fluid, and transmits the venous end pressure to the main control device;

The main control device obtains the venous end pressure, and performs digital filtering processing on the venous end pressure to obtain the filtered venous end pressure; compares the filtered venous end pressure with the target venous end pressure to obtain the comparison result; and according to the comparison result , Control the speed of the power pump equipment.

In one of the embodiments, it further includes a second pressure sensor arranged between the pulmonary artery of the isolated lung and the pipeline circulation device; the second sensor is connected to the main control device;

Wherein, the second pressure sensor collects the arterial end pressure of the perfusion fluid, and transmits the arterial end pressure to the main control device;

The main control device obtains the arterial end pressure, and performs digital filter processing on the arterial end pressure to obtain the filtered arterial end pressure; compares the filtered arterial end pressure with the target arterial end pressure to obtain the comparison result; and according to the comparison result , Control the speed of the power pump equipment.

In one of the embodiments, the flow sensor is an ultrasonic flow sensor.

In one of the embodiments, the power pump device includes a power pump head, a servo motor, and a motor driver connected between the servo motor and the main control device; the servo motor is mechanically connected to the power pump head.

In one of the embodiments, the motor driver is a brushless motor driver.

In one of the embodiments, the main control device includes a main controller, a human-computer interaction device, and an Internet of Things module for connecting to a mobile terminal;

The main controller is respectively connected to the human-computer interaction device and the Internet of Things module.

On the other hand, the embodiment of the present invention also provides a mechanical perfusion control method for the isolated lung, which includes the following steps:

When receiving a constant speed operation command, drive the power pump device according to the constant speed data corresponding to the constant speed operation command;

When a constant current operation instruction is received, the flow rate collected by the flow sensor is obtained according to the constant current operation instruction, and the flow is digitally filtered to obtain the filtered flow; the filtered flow and the target flow are subjected to PID adjustment processing to obtain processing As a result, the rotation speed of the power pump equipment is adjusted according to the processing result.

In one of the embodiments, the step of performing digital filtering processing on the flow to obtain the filtered flow includes:

Kalman filter processing is performed on the flow to obtain the filtered flow.

On the other hand, the embodiment of the present invention also provides a mechanical perfusion control device for the isolated lung, including:

The constant speed control unit is used to drive the power pump device according to the constant speed data corresponding to the constant speed operation command when the constant speed operation command is received;

The constant current control unit is used to obtain the flow rate collected by the flow sensor according to the constant current operation instruction when receiving the constant current operation instruction, and perform digital filtering processing on the flow rate to obtain the filtered flow rate; the filtered flow rate and the target flow rate Perform PID adjustment processing to obtain the processing result, and adjust the speed of the power pump equipment according to the processing result.

One of the above technical solutions has the following advantages and beneficial effects:

Based on this application, a constant pump speed mode or a constant flow rate mode can be selected for mechanical perfusion of the isolated lungs. Specifically, when the master control device receives a constant speed operation command, it can drive the power pump according to the constant speed data corresponding to the constant speed operation command The device realizes the perfusion of the constant pump speed mode; the main control device can also obtain the flow rate collected by the flow sensor according to the constant flow operation instruction, and perform digital filtering processing on the flow rate to obtain the filtered flow rate; the filtered flow rate and the target flow rate PID adjustment processing, and then can adjust the speed of the power pump equipment according to the obtained processing results. This application can realize multiple mechanical perfusion working modes of constant pump speed mode and constant flow rate mode, and is convenient to switch; by performing data filtering processing on the collected flow data, noise interference in the system is prevented, and the accuracy of data processing is improved; By performing PID adjustment processing on the filtered flow and the target flow, the accuracy of mechanical perfusion control of the isolated lung is further improved.

Description of the drawings

Fig. 1 is a schematic diagram of the first structure of the isolated lung mechanical perfusion control system in an embodiment;

2 is a schematic diagram of the second structure of the isolated lung mechanical perfusion control system in an embodiment;

3 is a schematic diagram of a third structure of the isolated lung mechanical perfusion control system in an embodiment;

Figure 4 is a schematic flow chart of a method for mechanical perfusion control of isolated lungs in an embodiment;

Fig. 5 is a schematic block diagram of an isolated lung mechanical perfusion control device in an embodiment.

detailed description

In order to facilitate the understanding of the application, the application will be described in a more comprehensive manner with reference to the relevant drawings. The preferred embodiment of the application is shown in the accompanying drawings. However, this application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of this application more thorough and comprehensive.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field of this application. The terminology used in the specification of the application herein is only for the purpose of describing specific embodiments, and is not intended to limit the application. The term "and/or" as used herein includes any and all combinations of one or more related listed items.

When the isolated lung is perfused in vitro, the donor lung protection has strict requirements on the perfusion rate. Too high or too low a rate will have a significant impact on the function of the donor lung. When the pulmonary blood vessels are not adequately lavaged, it will cause The incidence of pulmonary edema increases after perfusion; at the same time, improper flow perfusion will more easily damage endothelial cells and impair lung function. The current traditional isolated lung perfusion system has very limited perfusion time, the lung function decreases after perfusion, and the perfusion control accuracy is low.

In the isolated lung mechanical perfusion control system provided by the present application, the operator can freely select the constant pump speed mode or the constant flow rate mode to perform mechanical perfusion on the isolated lung, which can realize multiple modes of constant pump speed and constant flow rate. Mechanical perfusion working mode, easy to switch, realizes that the perfusate is delivered to the pulmonary artery according to the optimized flow or pump speed, and provides the nutrients needed for life to the isolated lungs; the collected flow data is filtered and processed to prevent noise in the system Interference improves the accuracy of data processing; by performing PID adjustment processing on the filtered flow and target flow, the accuracy of mechanical perfusion control of the isolated lung is further improved.

In one embodiment, as shown in Fig. 1, a mechanical perfusion control system for isolated lungs is provided, including:

The pipeline circulation device 110, which is used to connect with the pulmonary artery of the isolated lung;

Power pump device 120, which is used to transmit perfusion fluid to the pulmonary artery of the isolated lung; one end of the power pump device 120 is connected through the pulmonary vein of the isolated lung, and the other end is connected through the pipeline circulation device 110;

The flow sensor 130 is used to collect the flow of the perfusion liquid; the flow sensor 130 is arranged between the power pump device 120 and the pipeline circulation device 110;

The main control device 140, which is respectively connected to the power pump device 120 and the flow sensor 130;

Wherein, when the main control device 140 receives a constant speed operation instruction, it drives the power pump device 120 according to the constant speed data corresponding to the constant speed operation instruction; when the main control device 140 receives a constant current operation instruction, it drives the power pump device 120 according to the constant current operation instruction. , Obtain the flow collected by the flow sensor 130, and perform digital filtering processing on the flow to obtain the filtered flow; the main control device 140 performs PID adjustment processing on the filtered flow and the target flow to obtain the processing result, and adjust the power pump according to the processing result The speed of the device 120.

Specifically, the pipeline circulation device 110 can be used to inject perfusate into the pulmonary artery of the isolated lung, and can also be used to receive the liquid output from the pulmonary vein of the isolated lung to realize the circulatory perfusion of the isolated lung. The pipeline circulation device 110 may be connected to the pulmonary artery of the isolated lung through a pipeline. The power pump device 120 can be used to provide the power for the flow of perfusate during the perfusion process; based on the fact that one end of the power pump device 120 penetrates through the pulmonary vein connected to the isolated lung, the other end of the power pump device 120 penetrates the connecting pipeline circulation device 110, and then the power pump device 120 can drive the pipeline circulation device 110 so that the perfusion fluid output by the pipeline circulation device 110 is delivered to the pulmonary artery of the isolated lung, and the liquid output from the pulmonary vein of the isolated lung can be transported back to the pipeline circulation device 110. The flow sensor 130 can be used to collect the flow of the perfusate during the perfusion process. For example, the power pump device 120 and the pipeline circulation device 110 may be connected through a pipeline, and the flow sensor 130 may be provided on the pipeline.

Based on the main control device 140 being connected to the power pump device 120, the main control device 140 is connected to the flow sensor 130. The operator can select the constant pump speed mode or the constant flow rate mode to mechanically perfuse the isolated lungs. Specifically, when the master control device 140 receives a constant speed operation command, it drives the power pump device according to the constant speed data corresponding to the constant speed operation command 120. Realize the perfusion of the constant pump speed mode; the main control device 140 can also obtain the flow rate collected by the flow sensor according to the constant current operation instruction, and perform digital filtering processing on the flow rate to filter out noise, and then the filtered flow rate can be obtained; The filtered flow and the target flow are subjected to PID adjustment processing, and the rotation speed of the power pump device 120 can be adjusted according to the obtained processing result, so as to maintain a stable perfusion fluid flow. For example, if the processed result is that the filtered flow is greater than the target flow, the speed of the power pump device 120 is reduced according to the preset step value; the processed result is that the filtered flow is less than the target flow, and the power is increased according to the preset step value. The speed of the pump device 120. Among them, the constant rotation speed data may be the rotation speed data preset by the system.

It should be noted that PID (proportion, integral, and differential) adjustment refers to an adjustment method that uses proportion, integral, and derivative to calculate the control quantity for control based on system errors. For example, based on a proportional-integral-derivative (PID) controller, when the main control device 140 sets the target flow rate, the current filtered flow rate and the target flow rate are input into the proportional-integral-derivative controller for processing, and the processing result is obtained In turn, the rotation speed of the power pump device 120 can be adjusted according to the obtained processing result, so as to realize real-time rotation speed control of the power pump device 120.

In the above-mentioned isolated lung mechanical perfusion control system, a variety of mechanical perfusion working modes of constant pump speed mode and constant flow rate mode can be realized, and the switching is convenient; the collected flow data is processed by data filtering to prevent noise interference in the system , Improve the accuracy of data processing; through PID adjustment processing of the filtered flow and target flow, the accuracy of mechanical perfusion control of the isolated lung is further improved.

In a specific embodiment, the main control device performs Kalman filtering processing on the flow to obtain the filtered flow.

Among them, Kalman filtering refers to digital filtering that removes noise and restores real data. When the flow sensor transmits the collected flow data to the main control device, it is susceptible to noise interference, resulting in a certain deviation between the collected flow data and the real flow data. The main control device can perform Kalman filter processing on the acquired flow data, thereby filtering out noise interference and obtaining more accurate perfusion fluid flow.

In a specific embodiment, the flow sensor is an ultrasonic flow sensor.

Specifically, the ultrasonic flow sensor can be clamped on the pipeline between the power pump equipment and the pipeline circulation device, and then the flow can be measured by detecting the effect of the perfusion fluid flow in the pipeline on the ultrasonic beam (or ultrasonic pulse).

In one embodiment, as shown in Figure 2, an isolated lung mechanical perfusion control system is provided, which includes a pipeline circulation device 110, a power pump device 120, a flow sensor 130, and a main control device 140; The first pressure sensor 150 between the pulmonary veins of the lungs and the power pump device 120; the first pressure sensor 150 is connected to the main control device 140.

Among them, the first pressure sensor 150 collects the venous end pressure of the perfusion fluid and transmits the venous end pressure to the main control device 140; the main control device 140 obtains the venous end pressure, and performs digital filtering processing on the venous end pressure to obtain the filtered vein End pressure; compare the filtered venous end pressure with the target venous end pressure to obtain a comparison result; and control the speed of the power pump device 120 according to the comparison result.

Specifically, the first pressure sensor 150 refers to a device or device that can sense a pressure signal and convert the pressure signal into a usable output electrical signal according to a certain rule; the first pressure sensor 150 can be clamped in the body. On the pipe between the pulmonary veins of the lungs and the power pump device 120. Based on the connection of the first pressure sensor 150 to the main control device 140, when the perfusion fluid flows through the pipe between the pulmonary vein of the isolated lung and the power pump device 120, a certain pressure is generated on the pipe wall, and the first pressure sensor 150 The venous end pressure of the perfusion fluid in the pipeline can be monitored in real time, and the collected venous end pressure can be transmitted to the main control device 140. The main control device 140 can perform digital filtering processing on the acquired venous end pressure to obtain the filtered venous end pressure; compare the filtered venous end pressure with the target venous end pressure to obtain the comparison result; and according to the comparison result , Control the speed of the power pump device 120. For example, according to the comparison result, if the difference between the filtered venous pressure and the target venous pressure is within the allowable range, the power pump device 120 is controlled to keep the current state and continue to work, so that the entire perfusion system operates normally; The difference between the venous end pressure and the target venous end pressure exceeds the allowable range, indicating that the current perfusion fluid pressure is abnormal, and the power pump device 120 is disconnected, so that the power pump device 120 stops working.

Further, the main control device 140 may perform Kalman filter processing on the obtained venous end pressure, thereby filtering noise interference and obtaining a more accurate venous end pressure.

In a specific embodiment, it further includes a pressure plate connected between the main control device and the first pressure sensor. The pressure plate can be a pressure transmitter, and the pressure plate can be connected to the main control device through a serial port.

Specifically, based on the pressure plate connected between the main control device and the first pressure sensor, the first pressure sensor can transmit the collected venous end pressure to the pressure plate (the venous end pressure is a primary electrical signal), and the pressure plate can receive The received primary electrical signal of the venous end pressure is converted into a standard electrical signal that meets the main control device (for example, the current signal of the venous end pressure is converted from 4-20mA to 0-20mA, and the voltage signal from 0-10V is converted to 1-5V), And transmit the converted venous signal to the main control device.

It should be noted that the first pressure sensor may be a disposable medical pressure sensor.

In the above-mentioned isolated lung mechanical perfusion control system, the first pressure sensor can monitor the venous end pressure of the perfusion fluid in real time to ensure that the venous end pressure does not exceed a preset pressure limit value, and improve the reliability of mechanical perfusion of the isolated lung.

In one embodiment, as shown in Figure 2, an isolated lung mechanical perfusion control system is provided, which includes a pipeline circulation device 110, a power pump device 120, a flow sensor 130, and a main control device 140; The second pressure sensor 160 between the pulmonary artery of the body lung and the pipeline circulation device 110; the second sensor 160 is connected to the main control device 140.

Among them, the second pressure sensor 160 collects the arterial end pressure of the perfusion fluid, and transmits the arterial end pressure to the main control device 140; the main control device 140 obtains the arterial end pressure, and performs digital filtering processing on the arterial end pressure to obtain the filtered arterial pressure End pressure; compare the filtered arterial end pressure with the target arterial end pressure to obtain a comparison result; and control the speed of the power pump device 120 according to the comparison result.

Specifically, the second pressure sensor 160 refers to a device or device that can sense a pressure signal and convert the pressure signal into a usable output electrical signal according to a certain rule; the second pressure sensor 160 can be clamped on the body. On the pipe between the pulmonary artery of the lung and the pipeline circulation device 110. Based on the second pressure sensor 160 being connected to the main control device 140, when the perfusion fluid flows through the pipe between the pulmonary artery of the isolated lung and the pipeline circulation device 110, it will generate a certain pressure on the pipe wall, and then the second pressure sensor 160 can monitor the arterial end pressure of the perfusion fluid in the pipeline in real time, and transmit the collected arterial end pressure to the main control device 140. The main control device 140 can perform digital filtering processing on the acquired arterial end pressure to obtain the filtered arterial end pressure; compare the filtered arterial end pressure with the target arterial end pressure to obtain a comparison result; and according to the comparison result , Control the speed of the power pump device 120. For example, according to the comparison result, if the difference between the filtered arterial end pressure and the target arterial end pressure is within the allowable range, the power pump device 120 is controlled to keep the current state and continue to work, so that the entire perfusion system operates normally; The difference between the arterial end pressure and the target arterial end pressure exceeds the allowable range, indicating that the current perfusion fluid pressure is abnormal, and the power pump device 120 is disconnected, so that the power pump device 120 stops working.

Further, the main control device 140 may perform Kalman filter processing on the obtained arterial end pressure, so as to filter out noise interference and obtain a more accurate arterial end pressure.

In a specific embodiment, it further includes a second pressure plate connected between the main control device and the second pressure sensor. The second pressure plate can be a pressure transmitter, and the second pressure plate can be connected to the main control device through a serial port.

Specifically, based on that the second pressure plate is connected between the main control device and the second pressure sensor, the second pressure sensor can transmit the collected arterial end pressure (the arterial end pressure is a primary electrical signal) to the second pressure plate. The board can convert the received primary electrical signal of the arterial end pressure into a standard electrical signal that meets the main control device (for example, convert the current signal of the arterial end pressure 4-20mA to 0-20mA, and the voltage signal 0-10V to 1 -5V), and transmit the converted arterial end signal to the main control device.

It should be noted that the second pressure sensor may be a disposable medical pressure sensor.

In the above-mentioned isolated lung mechanical perfusion control system, the second pressure sensor can monitor the arterial end pressure of the perfusion fluid in real time to ensure that the arterial end pressure does not exceed the preset pressure limit value, and improve the reliability of mechanical perfusion of the isolated lung.

In an example, as shown in FIG. 2, an isolated lung mechanical perfusion control system provided by the present application may include a first pressure sensor 150 connected to the main control device 140 and a second pressure sensor 150 connected to the main control device 140. Sensor 160; the master control device 140 can monitor the venous pressure collected by the first pressure sensor 150 and the arterial pressure collected by the second pressure sensor 160 in real time; the master control device 140 can detect abnormal venous pressure or arterial pressure , The power pump device 120 is interrupted in time to prevent irreversible damage to the isolated lung.

In one embodiment, as shown in FIG. 3, an isolated lung mechanical perfusion control system is provided. The power pump device 120 includes a power pump head 122, a servo motor 124, and is connected between the servo motor 124 and the main control device 140. The motor driver 126; the servo motor 124 is mechanically connected to the power pump head 120.

Among them, the power pump head 122 may include an impeller, a bearing, a sealed rotating part, and the like. The servo motor 124 may be a permanent magnet AC servo motor. The motor driver 126 can be used to drive the servo motor 124 to rotate. In a specific embodiment, the motor driver 126 is a brushless motor driver.

Specifically, the power pump head 122 may be mechanically connected to the shaft of the servo motor 124, based on the motor driver 126 being connected between the servo motor 124 and the main control device 140, the main control device 140 controls the motor driver based on the constant pump speed mode or the constant flow rate mode 126 constant speed data), so that the motor driver 126 drives the servo motor 124 to rotate based on the constant current or constant speed constant speed data), and then the servo motor 124 drives the power pump head 122 to work to achieve precise control of the perfusion fluid flow rate.

Further, the motor driver 126 can be connected to the main control device 140 via an RS232 interface, and the main control device 140 can send corresponding instructions to the motor driver 126 via the RS232 interface, so as to control the servo motor 124 to rotate at a corresponding speed. In an example, the motor driver 126 can choose a driver with the characteristics of real-time feedback of the motor speed, which can read the current motor speed at any time; in addition, the servo motor 124 can be driven in a jog mode, and jog acceleration can be set , Jog deceleration, jog speed or jog stop, the use of jog method can effectively reduce the loss caused by the motor in the process of starting or stopping.

In one embodiment, as shown in FIG. 3, the main control device 140 includes a main controller 142, a human-computer interaction device 144, and an IoT module 146 for connecting to a mobile terminal; the main controller 142 is respectively connected to the human-computer interaction device 144 , The Internet of Things module 146.

Among them, the main controller 142 refers to a device with data processing and data transmission functions. The Internet of Things device 146 can be a WIFI (Wireless Fidelity, wireless Internet access) module, a GPRS (General Packet Radio Service, general packet radio service) module, a 3G (3rd-Generation, third-generation mobile communication technology) module, or a 4G (4th-Generation) module. , The fourth-generation mobile communication technology) module. The human-computer interaction device 144 may include a display device and an input device, and the display device may be a liquid crystal display device.

Specifically, based on the main controller 142 connected to the human-computer interaction device 144, the human-computer interaction device 144 can be used to display data such as the rotational speed of the power pump device 120 and the flow rate of the perfusion fluid transmitted by the main controller 142, and the user can adjust the power pump according to needs. The rotation speed and perfusion flow of the device 120. When an abnormality occurs in the system, the human-computer interaction device 144 may pop up a corresponding dialog box to prompt the user of the source of the abnormality, and recover after the user eliminates the abnormality. Based on the main controller 142 connected to the Internet of Things module 146, the main controller 142 can transmit perfusion data (such as speed and flow) to the mobile terminal through the physical network module 146, and the mobile terminal can monitor the perfusion process of the isolated lung (such as The corresponding data and curve data can be viewed through the corresponding APP), which is convenient for the operator to monitor, treat and evaluate the condition of the lungs; at the same time, it provides remote control and system error alarm functions to facilitate long-term isolated lung perfusion monitoring.

In one embodiment, as shown in Figure 4, a method for mechanical perfusion control of isolated lungs is provided, which includes the following steps:

In step S410, when the constant speed operation instruction is received, the power pump device is driven according to the constant speed data corresponding to the constant speed operation instruction.

Step S420, when the constant current operation instruction is received, obtain the flow rate collected by the flow sensor according to the constant current operation instruction, and perform digital filtering processing on the flow rate to obtain the filtered flow rate; perform PID adjustment processing on the filtered flow rate and the target flow rate , Get the processing result, and adjust the speed of the power pump equipment according to the processing result.

Specifically, when the master control device can receive a constant speed operation command, it can drive the power pump device according to the constant speed data corresponding to the constant speed operation command to achieve constant pump speed mode perfusion; the master control device can also follow the constant current operation command , Obtain the flow rate collected by the flow sensor, and perform digital filter processing on the flow rate to obtain the filtered flow rate; perform PID adjustment processing on the filtered flow rate and the target flow rate to obtain the processing result, and then adjust the speed of the power pump device according to the processing result. Realize multiple mechanical perfusion working methods of constant pump speed mode and constant flow rate mode, which is convenient to switch; by filtering the collected flow data, prevent noise interference in the system and improve the accuracy of data processing; by filtering The post flow and the target flow are subjected to PID adjustment processing, which further improves the accuracy of mechanical perfusion control of the isolated lung.

In a specific embodiment, the step of performing digital filtering processing on the flow to obtain the filtered flow includes:

Kalman filter processing is performed on the flow to obtain the filtered flow.

It should be understood that although the various steps in the flowchart of FIG. 4 are displayed in sequence as indicated by the arrows, these steps are not necessarily performed in sequence in the order indicated by the arrows. Unless there is a clear description in this article, there is no strict order for the execution of these steps, and these steps can be executed in other orders. Moreover, at least part of the steps in FIG. 4 may include multiple sub-steps or multiple stages. These sub-steps or stages are not necessarily executed at the same time, but can be executed at different times. The execution of these sub-steps or stages The sequence is not necessarily performed sequentially, but may be performed alternately or alternately with at least a part of other steps or sub-steps or stages of other steps.

In one embodiment, as shown in FIG. 5, a device for controlling mechanical perfusion of an isolated lung is provided, including:

The constant speed control unit 510 is configured to drive the power pump device according to the constant speed data corresponding to the constant speed operation instruction when the constant speed operation instruction is received.

The constant current control unit 520 is used to obtain the flow rate collected by the flow sensor according to the constant current operation instruction when receiving the constant current operation instruction, and perform digital filtering processing on the flow rate to obtain the filtered flow rate; and the filtered flow rate and the target The flow is subjected to PID adjustment processing, and the processing result is obtained, and the rotation speed of the power pump equipment is adjusted according to the processing result.

For the specific definition of the mechanical perfusion control device of the isolated lung, please refer to the above definition of the mechanical perfusion control method of the isolated lung, which will not be repeated here. The various modules in the above-mentioned isolated lung mechanical perfusion control device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in hardware form or independent of the processor in the isolated lung mechanical perfusion control system, or can be stored in the memory in the isolated lung mechanical perfusion control system in the form of software, so that the processor can call and execute The corresponding operations of the above modules.

In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored, and when the computer program is executed by a processor, the following steps are implemented:

A person of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be implemented by instructing relevant hardware through a computer program. The computer program can be stored in a non-volatile computer readable storage. In the medium, when the computer program is executed, it may include the processes of the above embodiments of the division operation methods. Wherein, any reference to memory, storage, database or other media used in the embodiments provided in this application may include non-volatile and/or volatile memory. Non-volatile memory may include read only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. As an illustration and not a limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous chain Channel (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, all possible combinations of the various technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, All should be considered as the scope of this specification.

The above-mentioned embodiments only express several implementation manners of the present application, and their description is relatively specific and detailed, but they should not be understood as a limitation on the scope of the invention patent. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of this application, several modifications and improvements can be made, and these all fall within the protection scope of this application. Therefore, the scope of protection of the patent of this application shall be subject to the appended claims.

Claims

A mechanical perfusion control system for isolated lungs, which is characterized in that it comprises:

A pipeline circulation device, which is used to connect with the pulmonary artery of the isolated lung;

Power pump equipment, the power pump equipment is used to drive the pipeline circulation device to transmit perfusate to the pulmonary artery of the isolated lung; one end of the power pump equipment is connected through the pulmonary vein of the isolated lung, and the other end Through connection with the pipeline circulation device;

A flow sensor, the flow sensor is used to collect the flow of the perfusion liquid; the flow sensor is arranged between the power pump equipment and the pipeline circulation device;

A main control device, the main control device is respectively connected to the power pump device and the flow sensor;

Wherein, when the master control device receives a constant speed operation instruction, it drives the power pump device according to the constant rotation speed data corresponding to the constant speed operation instruction;

When the master control device receives the constant current operation instruction, acquires the flow rate collected by the flow sensor according to the constant current operation instruction, and performs digital filtering processing on the flow rate to obtain the filtered flow rate; The main control device performs PID adjustment processing on the filtered flow rate and the target flow rate to obtain a processing result, and adjusts the rotation speed of the power pump device according to the processing result.
The isolated lung mechanical perfusion control system according to claim 1, further comprising a first pressure sensor provided between the pulmonary vein of the isolated lung and the power pump device; the first pressure sensor Connect to the master control device;

Wherein, the first pressure sensor collects the venous end pressure of the perfusion fluid, and transmits the venous end pressure to the main control device;

The main control device obtains the venous end pressure, and performs digital filtering processing on the venous end pressure to obtain the filtered venous end pressure; compares the filtered venous end pressure with the target venous end pressure to obtain the comparison The result; and according to the result of the comparison, the rotation speed of the power pump device is controlled.
The isolated lung mechanical perfusion control system according to claim 1, further comprising a second pressure sensor provided between the pulmonary artery of the isolated lung and the pipeline circulation device; the second sensor Connect to the master control device;

Wherein, the second pressure sensor collects the arterial end pressure of the perfusion fluid, and transmits the arterial end pressure to the main control device;

The main control device obtains the arterial end pressure, and performs digital filtering processing on the arterial end pressure to obtain the filtered arterial end pressure; compares the filtered arterial end pressure with the target arterial end pressure to obtain the comparison The result; and according to the result of the comparison, the rotation speed of the power pump device is controlled.
The isolated lung mechanical perfusion control system according to claim 1, wherein the flow sensor is an ultrasonic flow sensor.
The isolated lung mechanical perfusion control system according to claim 1, wherein the power pump device comprises a power pump head, a servo motor, and a motor driver connected between the servo motor and the main control device;

The servo motor is mechanically connected with the power pump head.
The isolated lung mechanical perfusion control system of claim 5, wherein the motor driver is a brushless motor driver.
The isolated lung mechanical perfusion control system according to claim 1, wherein the main control device comprises a main controller, a human-computer interaction device, and an Internet of Things module for connecting to a mobile terminal;

The main controller is respectively connected to the human-computer interaction device and the Internet of Things module.
A method for mechanical perfusion control of isolated lungs, which is characterized in that it comprises the following steps:

When receiving a constant speed operation instruction, drive the power pump device according to the constant speed data corresponding to the constant speed operation instruction;

When a constant current operation instruction is received, the flow rate collected by the flow sensor is obtained according to the constant current operation instruction, and the flow rate is digitally filtered to obtain the filtered flow rate; the filtered flow rate and the target flow rate are performed PID adjustment processing to obtain a processing result, and adjust the rotation speed of the power pump device according to the processing result.
The method for mechanical perfusion control of isolated lungs according to claim 8, wherein the step of performing digital filtering processing on the flow to obtain the filtered flow comprises:

Kalman filtering processing is performed on the flow to obtain the filtered flow.
A mechanical perfusion control device for isolated lungs, which is characterized in that it comprises:

The constant speed control unit is used to drive the power pump device according to the constant speed data corresponding to the constant speed operation instruction when the constant speed operation instruction is received;

The constant current control unit is configured to obtain the flow rate collected by the flow sensor according to the constant current operation instruction when receiving the constant current operation instruction, and perform digital filtering processing on the flow rate to obtain the filtered flow rate; The filtered flow rate and the target flow rate are subjected to PID adjustment processing to obtain a processing result, and the rotation speed of the power pump device is adjusted according to the processing result.