CN108144007A - Chinese medicinal tablet of pre- anti-cancer and preparation method thereof - Google Patents

Chinese medicinal tablet of pre- anti-cancer and preparation method thereof Download PDF

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CN108144007A
CN108144007A CN201710318269.8A CN201710318269A CN108144007A CN 108144007 A CN108144007 A CN 108144007A CN 201710318269 A CN201710318269 A CN 201710318269A CN 108144007 A CN108144007 A CN 108144007A
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袁宪林
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/83Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of Chinese medicinal tablets of pre- anti-cancer, according to mass percent, are made of following raw material:10~14 parts of Radix Angelicae Sinensis, 10~14 parts of Radix Rehmanniae, 10~14 parts of frankincense, 10~14 parts of radix scrophulariae, 4~8 parts of agalloch eaglewood, 10~14 parts of Cortex Eucommiae, 3~7 parts of Radix Glycyrrhizae, 10~14 parts of trigone, 10~14 parts of curcuma zedoary, 13~16 parts of rheum officinale.Invention additionally discloses the preparation methods of the Chinese medicinal tablet of above-mentioned pre- anti-cancer, remove the impurity contained in each Chinese medicine, are dried after rinsing;Each Chinese medicinal component after drying crushes, and is added water to cook three times after impregnating 45~50 hours, decoction liquor is mixed, filter after be concentrated under reduced pressure into thick paste solid;Thick paste solid is being crushed, is being sieved, the edible rubber powder of 2~5% mass fractions is added to mix thoroughly, round or other forms tablets are pressed into according to the preparation for processing of tablet.The Chinese medicinal tablet of the pre- anti-cancer of the present invention, good effect is quick, has no toxic side effect.

Description

Chinese medicinal tablet of pre- anti-cancer and preparation method thereof
Technical field
The invention belongs to drug preparation technique fields, are related to a kind of Chinese medicinal tablet of pre- anti-cancer, the invention further relates to this The preparation method of Chinese medicinal tablet.
Background technology
The morbidity and mortality of cancer rise year by year, serious threat human health, the main reason for becoming human death One of.Western medical treatment often brings nausea and loss of appetite, blood picture mostly based on operation, radiotherapy, chemotherapy after radiotherapy, chemotherapy The side effects such as variation, body's immunity damage, while cancer cell is suppressed or part is killed, human normal cell Also accordingly greatly wrecked and injured, thus cause many patients can not adhere to complete radiation and chemotherapy treatment course, Lose effective therapy apparatus meeting.
China fails the treatment of cancer to reach due effect at present, thus the focus for the treatment of cancer should be transferred to The aspect puted prevention first, because prevention just can make cancer not occur or occur less.
The traditional Chinese medical science thinks that the main reason for cancer occurs mostly is the deficiency of vital energy, blood stasis, poison knot, and disease belongs to body ressitance weakened while pathogenic factors prevailing;Pre- anti-cancer needs Start with from tonifying Qi, promoting blood circulation, removing toxic substances, help just, eliminating the pathogen can prove effective.
Invention content
The object of the present invention is to provide a kind of Chinese medicinal tablets of pre- anti-cancer, and pre- anti-cancer effect is good, has no toxic side effect.
It is a further object of the present invention to provide the preparation methods of above-mentioned Chinese medicinal tablet.
The technical solution adopted in the present invention is the Chinese medicinal tablet of pre- anti-cancer, including following raw material component:
10~14 parts of Radix Angelicae Sinensis, 10~14 parts of Radix Rehmanniae, 10~14 parts of frankincense, 10~14 parts of radix scrophulariae, 4~8 parts of agalloch eaglewood, Cortex Eucommiae 10 ~14 parts, 3~7 parts of Radix Glycyrrhizae, 10~14 parts of trigone, 10~14 parts of curcuma zedoary, 13~16 parts of rheum officinale.
Another technical solution of the present invention is,
The preparation method of the Chinese medicinal tablet of pre- anti-cancer, is specifically implemented according to the following steps:
Step 1
Component described in accordance with the claim 1 takes all kinds of Chinese medicines, removes the impurity contained in each Chinese medicine, is dried after rinsing;
Step 2
Each Chinese medicinal component after drying crushes, and is sieved using the sieve of 50~60 mesh, obtain grain size for 250 μm~ 300 μm of fine powder, then added water to cook three times after fine powder is impregnated 45~50 hours, it decocts add in 8 times of fine powder weight for the first time Water decocts 3 hours, and second of the water for decocting 6 times of addition fine powder weight decocts 2 hours, and third time, which decocts, adds in fine powder weight 4 Water again decocts 1 hour, obtains first time decoction liquor, second of decoction liquor, third time decoction liquor respectively;
Step 3
By the first time decoction liquor obtained in step 2, second of decoction liquor, the mixing of third time decoction liquor, filtering, filtered Liquid, then filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C;
Step 4
It is crushed after thick paste solid made from step 3 is dried under conditions of 60~70 DEG C, uses the sieve of 100~120 mesh Son is sieved, and obtains the fine powder of grain size≤150 μm, and in the fine powder plus the edible rubber powder of 2~5% mass fractions is mixed thoroughly, Preparation for processing according to tablet is pressed into round or other forms tablets.
The characteristics of another technical solution of the present invention, also resides in,
The specification of tablet is 0.4-0.6g/ pieces in the step 3.
Beneficial effects of the present invention:
1. a kind of Chinese medicinal tablet of pre- anti-cancer has tonifying Qi, promoting blood circulation, detoxicating functions, can effectively prevent cancerous lesion Occur, using Chinese herbal medicine formula, have no toxic side effect;
2. a kind of preparation method of the Chinese medicinal tablet of pre- anti-cancer, preparation process is simple, does not need to complex device, does not need to Complicated technology condition.
Specific embodiment
Below by specific embodiment, the present invention is described in detail.
The Chinese medicinal tablet of the pre- anti-cancer of the present invention, including following raw material component:
10~14 parts of Radix Angelicae Sinensis, 10~14 parts of Radix Rehmanniae, 10~14 parts of frankincense, 10~14 parts of radix scrophulariae, 4~8 parts of agalloch eaglewood, Cortex Eucommiae 10 ~14 parts, 3~7 parts of Radix Glycyrrhizae, 10~14 parts of trigone, 10~14 parts of curcuma zedoary, 13~16 parts of rheum officinale.
In the present invention, the effect of each raw material is in this drug and major function:
Radix Angelicae Sinensis:Warm-natured, acrid-sweet flavor has effects that following:
1. it enriches blood:Remarkably promote body hematopoiesis function, raising red blood cell, leucocyte and content of hemoglobin;
2. Adjust-blood lipid:Inhibit platelet aggregation, antithrombotic adjusts blood fat;
3. blood pressure lowering:It resists myocardial ischemia, arrhythmia cordis, expands blood vessel, reduce blood pressure;
4. strengthen immunity:Immune, the anti-inflammatory, liver protection of enhancing, radioresistance, anti-oxidant and removing free radical because etc..In addition, also Uterine smooth muscle can be adjusted.
Radix Rehmanniae:It is sweet in flavor, bitter, it is cold in nature, have the function of that clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, matter profit drop are let out.
Frankincense:The effect of arduous, temperature has regulating qi and activating blood, and analgesic therapy chases after poison, dispersing stagnated hepatoqi, gas in hemostasis living.
Radix scrophulariae:Acrid flavour, bitter, tepor has the effect of clearing heat and cooling blood, removing toxic substances, dissipating bind relieving sore-throat, enriching yin.For warm heat disease heat Enter ying blood, the card of consumption of YIN caused by febrile disease has the effect of clearing heat and cooling blood, removing toxic substances enriching yin.
Agalloch eaglewood:Acrid flavour, hardship, it is warm-natured, the effect of having in adjusting, tonifying five zang organs, benefiting male body essence and invigorating sex functions, warm up waist and knee, go perverse trend, evil can be treated Core poison swells, and removes bad odor.
Cortex Eucommiae:Sweet in flavor, warm-natured, energy filling liver kidney, strengthening the bones and muscles has effects that following:
1. blood pressure lowering:Reduce blood pressure, treatment of vascular hardening, coronary heart disease, anti-aging, antitumor etc. are effective in cure;
2. treat chronic disease:For chronic joint diseases, bone tuberculosis, dysmenorrhoea, dysfunctional uterine bleeding, chronic pelvic The diseases such as inflammation and there is caused by liver and kidney deficiency sign person.
Radix Glycyrrhizae:It is mild-natured, it is sweet in flavor, there are removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological actions such as anticancer.
Trigone:Bitter, it is mild-natured, there is the effect of blood-breaking, promoting the circulation of qi, Xiao Ji Zhi Tong.
Curcuma zedoary:There are promoting qi circulation and removing obstruction in the collateral, broken stasis of blood, the function of analgesic.There is antitumor, antiviral, antibacterial.
Rheum officinale:Bitter, it is cold in nature, have very strong anti-infectious function, anti-aging antioxidation, can adjust it is immune, anti- Inflammation, refrigeration function, resisting pathogenic microbes effect, reducing blood lipid, anastalsis, anti-gastric and duodenal ulcer, promote pancreatic secretion, Inhibit enzymatic activity, cholagogic, liver protection, discharge function, it is equal to a variety of Gram-positives and negative bacteria also with anti-infectious function Have inhibiting effect, be secondly corynebacterium diphtheriae wherein most sensitive for staphylococcus and streptococcus, Typhoid and paratyphoid bacillus, lung Scorching diplococcus, shigella dysenteriae etc..And the effects that hemostasis, liver protection, decompression, reduction serum cholesterol.
The preparation method of the Chinese medicinal tablet of the pre- anti-cancer of the present invention, is specifically implemented according to the following steps:
Step 1
Component described in accordance with the claim 1 takes all kinds of Chinese medicines, removes the impurity contained in each Chinese medicine, is dried after rinsing;
Step 2
Each Chinese medicinal component after drying crushes, and is sieved using the sieve of 50~60 mesh, obtain grain size for 250 μm~ 300 μm of fine powder, then added water to cook three times after fine powder is impregnated 45~50 hours, it decocts add in 8 times of fine powder weight for the first time Water decocts 3 hours, and second of the water for decocting 6 times of addition fine powder weight decocts 2 hours, and third time, which decocts, adds in fine powder weight 4 Water again decocts 1 hour, obtains first time decoction liquor, second of decoction liquor, third time decoction liquor respectively;
Step 3
By the first time decoction liquor obtained in step 2, second of decoction liquor, the mixing of third time decoction liquor, filtering, filtered Liquid, then filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C;
Step 4
It is crushed after thick paste solid made from step 3 is dried under conditions of 60~70 DEG C, uses the sieve of 100~120 mesh Son is sieved, and obtains the fine powder of grain size≤150 μm, and in the fine powder plus the edible rubber powder of 2~5% mass fractions is mixed thoroughly, Preparation for processing according to tablet is pressed into round or other forms tablets.
The specification of tablet is 0.4-0.6g/ pieces
The Chinese medicinal tablet of the pre- anti-cancer of the present invention, instructions of taking for two times a day, one time 5, continuously take 20~30 days It is as a treatment course.
The Chinese medicinal tablet of the pre- anti-cancer of the present invention, children, Pregnant and lactant women avoid use.
Pharmacodynamic experiment:
1. Niu, female, 38 years old.There is a lump on thigh, black, such as the back of the hand are big, take tablet one prepared by the present invention After a month, lump disappears.
2. Pan so-and-so, man, 43 years old.There is a black lump on esophagus, take the tablet of the invention prepared after two months, lump It disappears.
3. it is high so-and-so, man, 47 years old.It is blood fistula by hospital diagnosis, takes the tablet of the invention prepared after two weeks, symptom of having blood in stool It disappears, after taking one month, recovery from illness.
4. finding out 80~90 people in the crowd for having cancer heredity medication history, adhere to after taking tablet prepared by the present invention, Cancerous lesion is found without a people.
Embodiment 1
According to parts by weight, weigh respectively:12 parts of Radix Angelicae Sinensis, 12 parts of Radix Rehmanniae, 12 parts of frankincense, 12 parts of radix scrophulariae, 6 parts of agalloch eaglewood, Cortex Eucommiae 12 parts, 5 parts of Radix Glycyrrhizae, 12 parts of trigone, 12 parts of curcuma zedoary, 15 parts of rheum officinale;The impurity contained in each Chinese medicine is removed, is dried after rinsing;It will Each Chinese medicinal component after drying crushes, and is sieved using the sieve of 55 mesh, obtains the fine powder that grain size is 275 μm, then by fine powder It is added water to cook three times after impregnating 48 hours, first time decoction adds in the water of 8 times of fine powder weight, decocts 3 hours, and second of decoction adds Enter the water of 6 times of fine powder weight, decoct 2 hours, third time decocts the water for adding in 4 times of fine powder weight, decocts 1 hour, obtains respectively First time decoction liquor, second of decoction liquor, third time decoction liquor;First time decoction liquor, second of decoction liquor, third time are decocted Liquid mixing, filtering, obtain filtrate, then filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C;By thick paste solid at 65 DEG C Under conditions of dry after crush, be sieved using the sieve of 110 mesh, obtain grain size≤150 μm fine powder, in the fine powder The edible rubber powder of 3% mass fraction is added to mix thoroughly, round or other forms 0.5g/ are pressed into according to the preparation for processing of tablet The tablet of piece.
Embodiment 2
According to weight, weigh respectively:10 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of frankincense, 10 parts of radix scrophulariae, 4 parts of agalloch eaglewood, Cortex Eucommiae 10 Part, 3 parts of Radix Glycyrrhizae, 10 parts of trigone, 10 parts of curcuma zedoary, 13 parts of rheum officinale;The impurity contained in each Chinese medicine is removed, is dried after rinsing;It will shine Each Chinese medicinal component after dry crushes, and is sieved using the sieve of 50 mesh, obtains grain size and is 250 μm of fine powder, then fine powder is soaked Bubble adds water to cook three times after 45 hours, and first time decocts the water for adding in 8 times of fine powder weight, decocts 3 hours, and second of decoction adds in The water that 6 times of fine powder weight decocts 2 hours, and third time decocts the water for adding in 4 times of fine powder weight, decocts 1 hour, obtains the respectively Decoction liquor, second of decoction liquor, third time decoction liquor;By first time decoction liquor, second of decoction liquor, third time decoction liquor Mixing, filtering, obtain filtrate, then filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C;By thick paste solid at 60 DEG C Under the conditions of dry after crush, be sieved using the sieve of 100 mesh, obtain grain size≤150 μm fine powder, in the fine powder plus The edible rubber powder of 2% mass fraction is mixed thoroughly, and round or other forms 0.4g/ pieces are pressed into according to the preparation for processing of tablet Tablet.
Embodiment 3
According to weight, weigh respectively:14 parts of Radix Angelicae Sinensis, 14 parts of Radix Rehmanniae, 14 parts of frankincense, 14 parts of radix scrophulariae, 8 parts of agalloch eaglewood, Cortex Eucommiae 14 Part, 7 parts of Radix Glycyrrhizae, 14 parts of trigone, 14 parts of curcuma zedoary, 17 parts of rheum officinale;The impurity contained in each Chinese medicine is removed, is dried after rinsing;It will shine Each Chinese medicinal component after dry crushes, and is sieved using the sieve of 60 mesh, obtains grain size and is 300 μm of fine powder, then fine powder is soaked Bubble adds water to cook three times after 50 hours, and first time decocts the water for adding in 8 times of fine powder weight, decocts 3 hours, and second of decoction adds in The water that 6 times of fine powder weight decocts 2 hours, and third time decocts the water for adding in 4 times of fine powder weight, decocts 1 hour, obtains the respectively Decoction liquor, second of decoction liquor, third time decoction liquor;By first time decoction liquor, second of decoction liquor, third time decoction liquor Mixing, filtering, obtain filtrate, then filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C;By thick paste solid at 70 DEG C Under the conditions of dry after crush, be sieved using the sieve of 120 mesh, obtain grain size≤150 μm fine powder, in the fine powder plus The edible rubber powder of 5% mass fraction is mixed thoroughly, and round or other forms 0.6g/ pieces are pressed into according to the preparation for processing of tablet Tablet.

Claims (3)

1. the Chinese medicinal tablet of pre- anti-cancer, which is characterized in that the Chinese medicinal tablet includes following raw material component:
10~14 parts of Radix Angelicae Sinensis, 10~14 parts of Radix Rehmanniae, 10~14 parts of frankincense, 10~14 parts of radix scrophulariae, 4~8 parts of agalloch eaglewood, Cortex Eucommiae 10~14 Part, 3~7 parts of Radix Glycyrrhizae, 10~14 parts of trigone, 10~14 parts of curcuma zedoary, 13~16 parts of rheum officinale.
2. the preparation method of the Chinese medicinal tablet of pre- anti-cancer, which is characterized in that be specifically implemented according to the following steps:
Step 1
Component described in accordance with the claim 1 takes all kinds of Chinese medicines, removes the impurity contained in each Chinese medicine, is dried after rinsing;
Step 2
Each Chinese medicinal component after drying crushes, and is sieved using the sieve of 50~60 mesh, and acquisition grain size is 250 μm~300 μ The fine powder of m, then added water to cook three times after fine powder is impregnated 45~50 hours, the water for adding in 8 times of fine powder weight is decocted for the first time, is decocted It boils 3 hours, second of the water for decocting 6 times of addition fine powder weight decocts 2 hours, and third time, which decocts, adds in 4 times of fine powder weight Water decocts 1 hour, obtains first time decoction liquor, second of decoction liquor, third time decoction liquor respectively;
Step 3
By the first time decoction liquor obtained in step 2, second of decoction liquor, the mixing of third time decoction liquor, filtering, filtrate is obtained, Filtrate is concentrated under reduced pressure into thick paste solid under the conditions of 80 DEG C again;
Step 4
Crushed after thick paste solid made from step 3 is dried under conditions of 60~70 DEG C, using 100~120 mesh sieve into Row sieving obtains the fine powder of grain size≤150 μm, and in the fine powder plus the edible rubber powder of 2~5% mass fractions is mixed thoroughly, according to The preparation for processing of tablet is pressed into round or other forms tablets.
3. the preparation method of the Chinese medicinal tablet of pre- anti-cancer according to claim 2, which is characterized in that in the step 4 The specification of tablet is 0.4-0.6g/ pieces.
CN201710318269.8A 2017-05-08 2017-05-08 Chinese medicinal tablet of pre- anti-cancer and preparation method thereof Pending CN108144007A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1470264A (en) * 2003-06-07 2004-01-28 范兴合 Chinese medicinal decoction for preventing and treating cancer
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