CN114306549A - Traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, preparation and application - Google Patents
Traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, preparation and application Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, which is characterized by being suitable for qi deficiency and blood stasis, and comprising 30-60 g of astragalus, 15-20 g of ginseng, 15-20 g of angelica, 10-15 g of bighead atractylodes rhizome, 15-30 g of white peony root, 20-30 g of poria cocos, 10-15 g of ligusticum wallichii, 20-30 g of spina gleditsiae, 5-10 g of fructus amomi, 15-30 g of radix puerariae, 10-15 g of radix bupleuri and 5-10 g of honey-fried licorice root by weight. The present invention is used for regulating the function of triple energizer to improve the function of viscera, and the treatment is performed simultaneously in the upper, middle and lower regions and successively on the basis of the qi deficiency and blood stasis type viscera dysfunction. Promoting gastrointestinal function recovery; healing of the wound; the bones and muscles are healed; improving bone density; the time for lying in bed is shortened, and the recovery of the function of the organism is facilitated; and the complication is reduced. The ginseng-astragalus-blood decoction is used for treating patients with qi deficiency and blood stasis type viscera dysfunction, obviously improves the traditional Chinese medicine symptoms of qi deficiency and blood stasis type viscera dysfunction, and has statistical significance (P is less than 0.05). The total effective rate of the traditional Chinese medicine symptom curative effect reaches 92%, the control group is 79.17%, and the effect of the prescription of the invention is obviously superior to that of the conventional anti-inflammatory treatment.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions and preparations, and particularly relates to a traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, a preparation and an application.
Background
With the development of society and science and technology, the clinical medical level is continuously improved, the operation is widely applied as a modern medical means, the operation equipment and technology are also greatly improved, and meanwhile, the expected value of the patient on the postoperative recovery is also gradually improved. Clinically, the dominant blood loss and/or recessive blood loss caused by surgical trauma occur, and postoperative anemia, aggravated anemia or hypovolemic shock are easily caused. Foreign research shows that the incidence rate of anemia after orthopedic surgery can reach more than 80 percent, and the incidence rate of anemia after spine surgery is 82.7 percent for men and 85.8 percent for women. The incidence of anemia after operation is obviously higher than that before operation, and the blood management after operation is very important. The bleeding amount of the spinal surgery is large, and the allogenic blood transfusion rate is high. The average blood loss in the perioperative period is 1000-2000 ml, the hemoglobin (Hb) after the operation is reduced by 30-46 g/L, and the allogenic blood transfusion rate after the operation is up to 545-80%. Meanwhile, perioperative blood loss and uncorrected preoperative anemia increase the incidence of postoperative acute anemia, which is as high as 87% after hip fracture surgery. Perioperative anemia increases postoperative infection and death risk, prolongs hospitalization time, and affects postoperative functional rehabilitation and quality of life. The injuries before and during the operation cause the deficiency of qi and blood, fire excess due to yin deficiency and blood stasis in different degrees after the operation of patients. At present, clinically, traditional Chinese medicine body resistance strengthening medicines are also adopted for immune regulation, common medicines such as middle-jiao tonifying and qi tonifying decoction, four-monarch decoction, six-ingredient rehmannia decoction and the like which mainly tonify qi are used, although the common medicines are clinically beneficial to the anemia state of a patient and improve the recovery effect after an operation, the medicines do not consider the problems of yin and blood loss, excessive deficient fire and blood stasis internal resistance of the patient caused by the qi and blood loss of the patient actually occurring in clinic, so the effect of overall clinical prevention or control of the anemia of the patient is not ideal. How to fully consider the state that the organism of a patient is in the state of viscera dysfunction after operation, the physique is poor, the function is low, the immunity is reduced, the recovery capability is weakened, the basic state of the body of the patient is improved in a targeted manner through the treatment based on syndrome differentiation of traditional Chinese medicine, the anemia state of the patient can be inhibited or improved more ideally, the immunity of the body is enhanced, the postoperative recovery is improved beneficially, the research and development of a targeted traditional Chinese medicine formula for treating the postoperative anemia is worthy of deep research, a good way for accelerating the rehabilitation and the functional recovery of the patient is provided, and the clinical application potential is great.
Disclosure of Invention
The first purpose of the invention is to provide a traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction; further aims to provide a preparation of the traditional Chinese medicine composition and application.
The traditional Chinese medicine composition for treating qi-deficiency and blood-stasis type viscera dysfunction is suitable for qi-deficiency and blood-stasis type viscera dysfunction, and is composed of 30-60 g of astragalus membranaceus, 15-20 g of ginseng, 15-20 g of angelica sinensis, 10-15 g of bighead atractylodes rhizome, 15-30 g of white peony root, 20-30 g of poria cocos, 10-15 g of ligusticum wallichii, 20-30 g of spina gleditsiae, 5-10 g of fructus amomi, 15-30 g of radix puerariae, 10-15 g of radix bupleuri and 5-10 g of honey-fried licorice root by weight, and is suitable for qi-deficiency and blood-stasis type viscera dysfunction.
The further purpose is realized by adding medically acceptable auxiliary materials into the traditional Chinese medicine composition prescription of the traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, and preparing the traditional Chinese medicine composition into any one of decoction, granules, pills, tablets, capsules, paste, syrup, powder and powder.
The application of the traditional Chinese medicine composition in preparing the medicine for treating the visceral dysfunction.
The application of the traditional Chinese medicine composition in preparing the medicine for treating qi deficiency and blood stasis is provided.
Based on the theory of traditional Chinese medicine and a large amount of clinical practices, the inventor finds that the trauma can cause both qi and blood loss to cause yin and blood deficiency. The traditional Chinese medicine can promote wound healing from the aspects of tonifying qi and yin, nourishing blood and promoting blood circulation, and removing blood stasis and promoting tissue regeneration. The dialectical research of the traditional Chinese medicine shows that the patients have different degrees of qi deficiency and yin and blood deficiency after the operation. In the prior art, the 'strengthening of the body resistance' is used for immune regulation, such as middle-jiao and Qi tonifying decoction, four-monarch decoction, six-ingredient rehmannia decoction and other prescription medicines mainly for tonifying Qi, but only the Qi tonifying is usually regarded as important, and the pathological mechanisms of Yin-blood deficiency and excess fire of deficiency are ignored, so that the best treatment effect cannot be achieved by tonifying Qi in a single way. Pain, gastrointestinal dysfunction, delayed wound healing, and the like are often present. The pathogenesis of the disease can be summarized as pain caused by deficiency of qi and blood and pain caused by stagnation of qi and blood, or pain caused by obstruction of qi and blood, or both. Almost all major surgeries undergo a gastrointestinal function recovery process, and it is generally believed that post-operative overactivation of the enteric sympathetic nervous system is a major cause; secondly, the damage or stimulation to the gastrointestinal tract in the operation and the function of anesthetic drugs; and the postoperative intra-abdominal inflammation, electrolyte disorder and other factors have inhibition effect on gastrointestinal function. Just as the operation of traditional Chinese medicine damages primordial qi of human body and causes loss of qi and blood, loss of yin essence, loss of body fluid and blood stasis due to blood interruption, the dysfunction of viscera after operation, wherein the dysfunction of spleen and stomach in ascending and descending, dysfunction of transportation and transformation and obstruction of fu-organ qi are the main mechanisms causing gastrointestinal dysfunction. Spleen governs muscles, and is the source of qi and blood generation, and dysfunction of spleen and stomach makes biochemistry passive, and fails to nourish muscles, bones and muscles, and causes delayed healing of wound and slow growth of callus. Therefore, it is the cause of this disease. The symptoms of damp-heat invasion, qi consumption and blood impairment caused by long-term strain, falling injury, operative treatment and the like are the most common, and the clinical manifestations of the symptoms are hypoimmunity, anemia, pain, hectic fever, night sweat, sore throat, aphthous stomatitis, listlessness, short breath, talk reluctance, insomnia, anorexia, constipation, urinary retention and the like. Therefore, the syndrome is qi deficiency and blood stasis. Determining a therapeutic rule: strengthening body resistance to eliminate pathogenic factors and treating both principal and secondary aspects of diseases; therapeutic method: replenishing qi to invigorate the spleen, operating the pivot, nourishing blood and regulating blood, and removing blood stasis and dredging collaterals.
In the formula of the invention, astragalus and ginseng are used as monarch drugs. The astragalus root is sweet and warm and can tonify well, enter spleen and lung channels, tonify qi and raise yang, and promote sore and granulation; ginseng is sweet and bitter, slightly warm, enters spleen and lung channels, and has the effects of invigorating primordial qi, tonifying spleen and lung, promoting the production of body fluid, relieving thirst, tranquilizing mind and improving intelligence. The two herbs are combined to tonify invisible qi and promote generation of visible blood. Qi has the ability of warming and promoting, so as to circulate blood throughout the body, distribute essence, nourish viscera, limbs, bones and sense organs, and consolidate blood lost during trauma or surgery.
Chinese angelica, white peony root, white atractylodes rhizome and tuckahoe are ministerial drugs. The angelica has sweet and pungent taste and warm nature, enters liver, heart and spleen channels, can enrich and activate blood, remove blood stasis and promote tissue regeneration, and supplement tangible blood to help the astragalus and the ginseng to generate intangible qi; white peony root is bitter, sour and sweet in taste and slightly cold in nature, enters liver and spleen channels, can nourish blood and liver, combines Chinese angelica with the functions of enriching blood, nourishing liver, filling blood, removing blood impediment, breaking hardness, accumulating cold and heat, relieving pain, promoting urination and tonifying qi; the white atractylodes rhizome is bitter and sweet in taste and warm in nature, enters spleen and stomach channels, invigorates qi and strengthens spleen, eliminates dampness and promotes diuresis; poria cocos, is sweet and mild in nature, enters heart, spleen and kidney channels, strengthens spleen, soothes nerves, promotes diuresis and excretes dampness. The combination of the largehead atractylodes rhizome and the Indian buead has the effects of tonifying qi, strengthening spleen, tonifying middle-jiao and promoting diuresis, and helps monarch drugs to tonify middle-jiao and generate yin and blood. The ministerial drugs and the monarch drugs are mutually reinforced for supplementing qi and enriching blood, harmonizing middle energizer and strengthening the source of qi-blood generation.
Rhizoma Ligustici Chuanxiong, spina Gleditsiae, fructus Amomi, radix Puerariae, and bupleuri radix as adjuvant drugs. The rhizome of Sichuan lovage, rhizoma Ligustici Chuanxiong, with pungent and warm properties, enters liver, gallbladder and pericardium channels, promotes qi and blood circulation, and removes blood stasis; spina Gleditsiae is pungent and warm in flavor and is effective in dispersing pathogen accumulation, dispersing pathogenic wind, expelling pus, expelling toxin, and dredging meridians; fructus Amomi, pungent in flavor and warm in property, moves qi and dampness, invigorates spleen and stomach, stimulates appetite, warms middle energizer and stops diarrhea; the kudzu root is sweet and pungent in flavor, cool in nature, enters spleen and stomach channels, passes through twelve meridians, raises yang and lifts sinking, relieves fever and promotes fluid production, relieves muscle and pain, and clears and activates the channels and collaterals; the radix bupleuri is bitter and pungent in flavor and cool in nature, enters liver and gallbladder channels, soothes liver and regulates qi, helps spleen to ascend clear, and relieves fever. Kudzuvine root and radix bupleuri are combined with monarch drugs to tonify qi and raise yang, and also to release exterior and release muscles, defervesce and promote the production of body fluid to eliminate qi deficiency and fever, and to treat postoperative body weakness and susceptibility to wind-cold. The adjuvant drugs are used together to have the effects of operating the pivot, promoting blood circulation, removing blood stasis, dredging collaterals, and relieving swelling and pain.
Prepared licorice root, radix Glycyrrhizae Praeparata, as an adjuvant and guiding drug. The medicine has sweet taste and can tonify and moderate, enter spleen, stomach, lung and heart channels, tonify middle-jiao and harmonize other drugs; mixing radix astragali, radix Ginseng, and fructus Amomi, and having effects of invigorating yang, invigorating qi, and promoting hematopoiesis; and the combined white peony root has the functions of sweetening and yin-eliminating, relieving spasm and relieving pain.
The invention strengthens the body resistance to eliminate pathogenic factors and strengthens the qi transformation of middle energizer to regulate the functions of viscera. The spleen and stomach are both in the middle energizer, which is the acquired root and the origin of qi and blood, and the food reception and transportation between them are the mutual factors of qi movement and qi movement, and yin and yang dryness and dampness are the mutual factors of qi movement, maintaining the generation of food qi, the absorption and transportation of essence and body fluids, which are the pivotal points of the qi movement balance of the five zang-organs and six fu-organs. The formula focuses on the physiological functions and pathological manifestations of the spleen and stomach, and is a non-negligible link, so that the formula treats the diseases by tonifying without affecting stagnation, eliminating without hurting the body resistance, orderly receiving, transporting, ascending and descending, sufficient in biochemical source, enhanced in curative effect and capable of curing the diseases after being treated. While treating other viscera, the spleen and stomach are nourished, namely, the spleen and stomach are cultivated to nourish qi and help qi transformation and support the source of transformation. The medicine can enter the stomach to obtain normal administration compress, ensure better absorption of the medicine, directly reach the focus of disease, fully exert the efficacy of resisting and treating the pathogenic factors and improve the treatment effect. The whole formula has the effects of regulating the three jiao simultaneously, treating the five internal organs simultaneously, tonifying qi and spleen, operating the pivot, nourishing blood and blood, and removing blood stasis and dredging collaterals. The modern pharmacological research result shows that the whole formula of the medicine has the effects of tonifying qi, enriching the blood, promoting blood circulation, stopping bleeding, relieving pain, promoting granulation, reuniting bones, strengthening muscles and the like; can improve the immunity of the organism, promote the healing after injury, relieve pain, reduce postoperative complications and the like, and has targeting effect on treating qi deficiency and blood stasis type viscera dysfunction.
The invention aims at the treatment of qi deficiency and blood stasis type viscera dysfunction to adjust the gasification effect of triple energizer and improve the viscera function, and the ginseng and the astragalus root which are prepared by ginseng and astragalus root decoction are used for tonifying the qi of the upper, middle and lower triple energizer of lung, spleen and kidney to quickly generate lost blood; the angelica has the functions of nourishing blood and promoting blood circulation and is helpful for qi tonifying and blood generation of the ginseng and the astragalus; bighead atractylodes rhizome and tuckahoe are healthy and healthy to transport the middle energizer to help the source of qi and blood generation; the white paeony root, the angelica and the liquorice are combined with the liver and the spleen for simultaneous treatment, so that the liver blood is nourished, the urgency is relieved, the pain is relieved, and the middle-warmer energy is tonified; the two herbs are used together to soothe the liver and regulate the spleen, and smooth the middle and upward flow, so as to not only activate the liver-qi, but also promote the spleen to ascend and clear, which is the key to operate the pivot, and can achieve the effect of four-stirring and two-stirring. The invention has precise and appropriate compatibility, and the medicine is used for reducing and clearing heat, which is beneficial to promoting the gastrointestinal function recovery; healing of the wound; the bones and muscles are healed; improving bone density; the time for lying in bed is shortened, and functional activities are recovered as early as possible; and the complication is reduced.
The invention treats patients with qi deficiency and blood stasis type viscera dysfunction, and the treatment group and the control group both obviously improve the traditional Chinese medicine symptoms (P is less than 0.05). It shows that the two groups have certain advantages for improving the symptoms of visceral dysfunction. The symptom scores of the two groups after treatment are compared, and the treatment group is obviously superior to the control group and has statistical significance (P < 0.05). The total effective rate of the traditional Chinese medicine symptom curative effect reaches 92 percent in the treatment group and 79.17 percent in the control group, and the ginseng, astragalus and blood decoction in the treatment group is further proved to be superior to the conventional control group in the traditional Chinese medicine symptom curative effect on treating the qi deficiency and blood stasis type viscera dysfunction patients.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the technical teaching of the present invention are intended to fall within the scope of the present invention.
The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction is suitable for qi deficiency and blood stasis, and comprises, by weight, 30-60 g of astragalus membranaceus, 15-20 g of ginseng, 15-20 g of angelica sinensis, 10-15 g of bighead atractylodes rhizome, 15-30 g of white peony root, 20-30 g of poria cocos, 10-15 g of ligusticum wallichii, 20-30 g of spina gleditsiae, 5-10 g of fructus amomi, 15-30 g of radix puerariae, 10-15 g of radix bupleuri and 5-10 g of honey-fried licorice root, and is suitable for qi deficiency and blood stasis type viscera dysfunction.
8-12 g of pseudo-ginseng, 10-15 g of teasel root and 10-15 g of suberect spatholobus stem are added into the traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, so that the traditional Chinese medicine composition is suitable for qi deficiency and blood stasis, and also has the symptoms of blood stasis blocking collaterals and flaccidity of bones and muscles; the effects of removing blood stasis, dredging collaterals and strengthening tendons and bones are achieved, and the three components are combined to strengthen the forces of promoting blood circulation, removing blood stasis, nourishing blood, stopping bleeding and tonifying liver and kidney.
The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction disease is characterized in that 10-15 g of rhizoma atractylodis and 8-12 g of fructus aurantii are added, and the traditional Chinese medicine composition is suitable for qi deficiency and blood stasis disease and has the symptoms of dysfunction of transportation and transformation and obstruction of fu-organ qi; achieves the effects of activating spleen and regulating middle warmer, eliminating dampness with aromatics, and ascending and descending qi, and the two are combined to strengthen the actions of activating spleen and drying dampness, and ventilating fu-organ qi.
The Chinese medicinal composition for treating qi deficiency and blood stasis type viscera dysfunction disease is suitable for qi deficiency and blood stasis diseases accompanied with yin deficiency and fire excess and essence and blood deficiency, and 20-30 g of Chinese yam and 15-20 g of prepared rehmannia root are added into the Chinese medicinal composition; achieves the efficacies of nourishing yin of heart, liver and kidney and tonifying essence and blood, and the two are used together to strengthen the power of replenishing yin essence and nourishing yin and blood.
According to the traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction, 8-12 g of radix ophiopogonis and 10-15 g of roasted rhizoma polygonati are added, so that the traditional Chinese medicine composition is suitable for qi deficiency and blood stasis, and is accompanied with spleen-lung essence deficiency and deficient fire flaming; has the effects of nourishing lung yin, benefiting stomach and promoting fluid production, and can be used for nourishing yin, lowering fire, promoting fluid production and stopping drinking.
The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction disease is characterized in that 10-15 g of platycladi seed, 10-15 g of fructus cannabis and 4-8 g of rhubarb are added into the traditional Chinese medicine composition, and the traditional Chinese medicine composition is suitable for qi deficiency and blood stasis disease accompanied with essence deficiency constipation; the three components are combined to reinforce the action of moistening the intestines, purging, and relaxing the bowels.
The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction is prepared by adding medically acceptable auxiliary materials into a formula of the traditional Chinese medicine composition and preparing into any one of decoction, granules, pills, tablets, capsules, paste, syrup, powder and powder.
The preparation of the decoction of the traditional Chinese medicine composition preparation for treating qi deficiency and blood stasis type viscera dysfunction disease comprises the following steps: putting all the medicines into a pot, adding water to submerge the medicines for 2-3 cm, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, and taking about 150ml of juice; adding appropriate amount of water again, boiling with strong fire, decocting with slow fire for 10min, collecting about 150ml of decoction, and mixing decoctions to obtain decoction.
The granules of the traditional Chinese medicine composition preparation for treating qi deficiency and blood stasis type viscera dysfunction disease are prepared by the following procedures:
(1) decocting: the weight ratio of the components to the liquid medicine is 1: decocting the raw materials in water for 1-3 times, each time for 25-35 min, and combining decoction liquids;
(2) concentration: concentrating the obtained decoction at 60-75 ℃ under the vacuum degree of-0.02 to-0.06 MPa to form thick paste, wherein the relative density of the thick paste at 50-60 ℃ is 1.20-1.35 g/ml;
(3) and (3) drying: drying the thick paste at 60-75 ℃ under the vacuum degree of-0.02 to-0.06 MPa to form dry paste for later use;
(4) and (3) granulating: crushing the dry paste, sieving the crushed dry paste with a 100-mesh sieve to obtain mixed dry paste powder, adding 20-40 g of granulation auxiliary materials, uniformly mixing, adding a proper amount of 50-75% ethanol, carrying out wet granulation, and drying to obtain granules.
The granulating auxiliary material is one or the combination of more than one of starch, dextrin or powdered sugar.
The traditional Chinese medicine composition preparation pill for treating qi deficiency and blood stasis type viscera dysfunction is prepared by the following steps:
(1) decocting: weighing the medicinal materials in the formula according to the formula amount, and mixing the medicinal materials in a weight ratio of 1: decocting the raw materials in water for 1-3 times, each time for 25-35 min, and combining decoction liquids;
(2) concentration: concentrating the obtained decoction at 60-75 ℃ under the vacuum degree of-0.02 to-0.06 MPa to form thick paste, wherein the relative density of the thick paste at 50-60 ℃ is 1.20-1.35 g/ml;
(3) and (3) drying: drying the thick paste at 60-75 ℃ under the vacuum degree of-0.02 to-0.06 MPa to form dry paste for later use;
(4) pelleting: crushing the dry paste, sieving the crushed dry paste by a sieve of 100 meshes to obtain mixed dry paste powder, adding 60-80 g of pelleting auxiliary materials, uniformly mixing, and preparing pills by water or ethanol with concentration of 40% or less.
The granulating auxiliary material is one or more of honey, maltose, starch, dextrin or powdered sugar.
Example 1
The formula is as follows: 40g of astragalus, 15g of ginseng, 15g of angelica, 15g of bighead atractylodes rhizome, 15g of white paeony root, 25g of tuckahoe, 10g of szechuan lovage rhizome, 20g of spina gleditsiae, 10g of fructus amomi, 15g of kudzuvine root, 10g of radix bupleuri and 5g of honey-fried licorice root. Putting all the medicines into a pot according to the formula, adding water to submerge the medicines by 2-3 cm, soaking for 30min, boiling with strong fire, decocting with slow fire for 30min, and taking about 150ml of juice; adding appropriate amount of water again, boiling with strong fire, decocting with slow fire for 10min, collecting about 150ml of decoction, and mixing decoctions to obtain decoction.
Example 2
The formula is as follows: 60g of astragalus, 20g of ginseng, 20g of angelica, 10g of bighead atractylodes rhizome, 30g of white paeony root, 30g of tuckahoe, 15g of szechuan lovage rhizome, 30g of spina gleditsiae, 5g of villous amomum fruit, 30g of kudzuvine root, 15g of Chinese thorowax root and 10g of honey-fried licorice root. Decocting the medicinal materials in the formula with water for 1-3 times according to the weight ratio of the medicinal water of 1:12, 50min each time, and combining decoction liquids; concentrating the obtained decoction at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 40g sucrose, mixing, adding appropriate amount of 75% ethanol, wet granulating, and drying to obtain granule.
Example 3
The formula is as follows: 30g of astragalus, 20g of ginseng, 15g of angelica, 10g of bighead atractylodes rhizome, 20g of white paeony root, 20g of tuckahoe, 10g of szechuan lovage rhizome, 25g of spina gleditsiae, 5g of fructus amomi, 25g of kudzuvine root, 15g of radix bupleuri and 10g of honey-fried licorice root. The weight ratio of the components to the liquid medicine is 1:8, adding water, decocting for 1-3 times, each time for 40min, and combining decoction liquids; concentrating the obtained decoction at 60 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 60 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 50g starch, mixing, and making into pill with water. .
Example 4
The formula is as follows: 50g of astragalus membranaceus, 20g of ginseng, 15g of angelica sinensis, 10g of bighead atractylodes rhizome, 20g of radix paeoniae alba, 20g of poria cocos, 15g of ligusticum wallichii, 30g of spina gleditsiae, 5g of fructus amomi, 20g of radix puerariae, 10g of radix bupleuri, 10g of honey-fried licorice root, 12g of pseudo-ginseng, 10g of radix dipsaci and 10g of caulis spatholobi. Weighing the medicinal materials in the formula according to the formula amount, adding water according to the weight ratio of 1:10 of the medicinal water, decocting for 1-3 times, each time for 30min, and combining decoction; concentrating the obtained decoction at 70 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.20g/ml at 50 deg.C; drying the soft extract at 70 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 60g Mel, mixing, and making into pill with 30% ethanol. The recipe is suitable for the symptoms of qi deficiency and blood stasis, as well as the symptoms of blood stasis blocking collaterals and flaccidity of muscles and bones; the effects of removing blood stasis, dredging collaterals and strengthening tendons and bones are achieved, and the three components are combined to strengthen the forces of promoting blood circulation, removing blood stasis, nourishing blood, stopping bleeding and tonifying liver and kidney.
Example 5
The formula is as follows: 55 g of astragalus membranaceus, 15g of ginseng, 20g of angelica sinensis, 10g of bighead atractylodes rhizome, 25g of radix paeoniae alba, 25g of poria cocos, 10g of ligusticum wallichii, 30g of spina gleditsiae, 10g of fructus amomi, 25g of radix puerariae, 15g of radix bupleuri, 5g of honey-fried licorice root, 8g of pseudo-ginseng, 15g of radix dipsaci and 15g of caulis spatholobi. Decocting the components in water for 1-3 times according to the weight ratio of the medicinal water of 1:10, each time for 30min, and combining the decoction; concentrating the obtained decoction at 70 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 70 deg.C under-0.02 to-0.06 MPa vacuum degree to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 30g starch, mixing, adding 70% ethanol, wet granulating, and drying to obtain granule. The recipe is suitable for the symptoms of qi deficiency and blood stasis, as well as the symptoms of blood stasis blocking collaterals and flaccidity of muscles and bones; the effects of removing blood stasis, dredging collaterals and strengthening tendons and bones are achieved, and the three components are combined to strengthen the forces of promoting blood circulation, removing blood stasis, nourishing blood, stopping bleeding and tonifying liver and kidney.
Example 6
The formula is as follows: 35g of astragalus membranaceus, 20g of ginseng, 15g of angelica sinensis, 15g of bighead atractylodes rhizome, 20g of radix paeoniae alba, 20g of poria cocos, 15g of ligusticum wallichii, 20g of spina gleditsiae, 10g of fructus amomi, 20g of radix puerariae, 10g of radix bupleuri, 10g of honey-fried licorice root, 10g of rhizoma atractylodis and 12g of fructus aurantii. Weighing the medicinal materials in the formula according to the formula amount, adding water according to the weight ratio of 1:10 of the medicinal water, decocting for 1-3 times, 60min each time, and combining decoction; concentrating the obtained decoction at 65 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 65 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 60g maltose, mixing, and making into pill with 20% ethanol. The formula is suitable for qi deficiency and blood stasis, and also has the symptoms of dysfunction of transportation and transformation and obstruction of fu-organ qi; achieves the effects of activating spleen and regulating middle warmer, eliminating dampness with aromatics, and ascending and descending qi, and the two are combined to strengthen the actions of activating spleen and drying dampness, and ventilating fu-organ qi.
Example 7
The formula is as follows: 45g of astragalus, 20g of ginseng, 20g of angelica, 15g of bighead atractylodes rhizome, 30g of white paeony root, 25g of poria cocos, 15g of ligusticum wallichii, 30g of spina gleditsiae, 5g of fructus amomi, 15g of radix puerariae, 10g of radix bupleuri, 10g of honey-fried licorice root, 15g of rhizoma atractylodis and 8g of fructus aurantii. Adding water into the components according to the weight ratio of 1:8 of the medicinal water, decocting for 1-3 times, each time for 45min, and combining decoction; concentrating the obtained decoction at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 30g sucrose, mixing, adding 60% ethanol, wet granulating, and drying to obtain granule. The formula is suitable for qi deficiency and blood stasis, and also has the symptoms of dysfunction of transportation and transformation and obstruction of fu-organ qi; achieves the effects of activating spleen and regulating middle warmer, eliminating dampness with aromatics, and ascending and descending qi, and the two are combined to strengthen the actions of activating spleen and drying dampness, and ventilating fu-organ qi.
Example 8
The formula is as follows: 60g of astragalus membranaceus, 15g of ginseng, 15g of angelica sinensis, 10g of bighead atractylodes rhizome, 15g of radix paeoniae alba, 20g of poria cocos, 15g of ligusticum wallichii, 20g of spina gleditsiae, 5g of fructus amomi, 15g of radix puerariae, 15g of radix bupleuri, 5g of honey-fried licorice root, 20g of Chinese yam and 20g of prepared rehmannia root. Weighing the medicinal materials in the formula according to the formula amount, adding water according to the weight ratio of 1:8 of the medicinal water, decocting for 1-3 times, 60min each time, and combining decoction; concentrating the obtained decoction at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 60g sugar powder, mixing, and making into pill with 40% ethanol. The formula is suitable for the symptoms of qi deficiency and blood stasis, accompanied with yin deficiency and fire excess and essence and blood deficiency; achieves the efficacies of nourishing yin of heart, liver and kidney and tonifying essence and blood, and the two are used together to strengthen the power of replenishing yin essence and nourishing yin and blood.
Example 9
The formula is as follows: 30g of astragalus, 20g of ginseng, 20g of angelica, 15g of bighead atractylodes rhizome, 30g of white paeony root, 30g of tuckahoe, 15g of szechuan lovage rhizome, 30g of spina gleditsiae, 10g of fructus amomi, 30g of kudzuvine root, 15g of radix bupleuri, 10g of honey-fried licorice root, 30g of Chinese yam and 15g of prepared rehmannia root. The weight ratio of the components to the liquid medicine is 1: 7, adding water, decocting for 1-3 times, each time for 40min, and combining decoction liquids; concentrating the obtained decoction into thick paste at 65 ℃ and under the vacuum degree of-0.02-0.06 MPa, wherein the relative density of the thick paste at 50 ℃ is 1.20 g/ml; drying the soft extract at 65 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 40g starch, mixing, adding 70% ethanol, wet granulating, and drying to obtain granule. The formula is suitable for the symptoms of qi deficiency and blood stasis, accompanied with yin deficiency and fire excess and essence and blood deficiency; achieves the efficacies of nourishing yin of heart, liver and kidney and tonifying essence and blood, and the two are used together to strengthen the power of replenishing yin essence and nourishing yin and blood.
Example 10
The formula is as follows: 50g of astragalus membranaceus, 20g of ginseng, 20g of angelica sinensis, 10g of bighead atractylodes rhizome, 15g of radix paeoniae alba, 25g of poria cocos, 15g of ligusticum wallichii, 25g of spina gleditsiae, 10g of fructus amomi, 25g of radix puerariae, 10g of radix bupleuri, 10g of honey-fried licorice root, 8g of radix ophiopogonis and 15g of roasted rhizoma polygonati. Weighing the medicinal materials in the formula according to the formula amount, adding water according to the weight ratio of 1:8 of the medicinal water, decocting for 1-3 times, each time for 35min, and combining decoction; concentrating the obtained decoction at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 60 dextrin, mixing, and making into pill with 40% ethanol. The formula is suitable for qi deficiency and blood stasis, and also has the symptoms of spleen-lung essence deficiency and deficient fire flaming; has the effects of nourishing lung yin, benefiting stomach and promoting fluid production, and can be used for nourishing yin, lowering fire, promoting fluid production and stopping drinking.
Example 11
The formula is as follows: 40g of astragalus, 15g of ginseng, 15g of angelica, 15g of bighead atractylodes rhizome, 30g of white paeony root, 30g of tuckahoe, 15g of szechuan lovage rhizome, 20g of spina gleditsiae, 5g of fructus amomi, 15g of kudzuvine root, 10g of radix bupleuri, 10g of honey-fried licorice root, 12g of dwarf lilyturf tuber and 10g of roasted rhizoma polygonati. Decocting the components in water for 1-3 times according to the weight ratio of the medicinal water of 1:8, each time for 50min, and combining the decoction; concentrating the obtained decoction at 70 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.20g/ml at 50 deg.C; drying the soft extract at 70 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 30g dextrin, mixing, adding 60% ethanol, wet granulating, and drying to obtain granule. The formula is suitable for qi deficiency and blood stasis, and also has the symptoms of spleen-lung essence deficiency and deficient fire flaming; has the effects of nourishing lung yin, benefiting stomach and promoting fluid production, and can be used for nourishing yin, lowering fire, promoting fluid production and stopping drinking.
Example 12
The formula is as follows: 55 g of astragalus, 15g of ginseng, 20g of angelica, 10g of bighead atractylodes rhizome, 20g of white peony root, 20g of poria cocos, 15g of ligusticum wallichii, 30g of spina gleditsiae, 10g of fructus amomi, 20g of radix puerariae, 10g of radix bupleuri, 10g of honey-fried licorice root, 15g of platycladi seed, 15g of fructus cannabis and 4g of rheum officinale. Weighing the medicinal materials in the formula according to the formula amount, and mixing the medicinal materials in a weight ratio of 1: 9, adding water, decocting for 1-3 times, each time for 30min, and combining decoction liquids; concentrating the obtained decoction at 60 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.35g/ml at 60 deg.C; drying the soft extract at 60 deg.C under-0.02-0.06 MPa vacuum to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, and making into pill with 20% ethanol. The formula is suitable for qi deficiency and blood stasis with the symptoms of essence deficiency and constipation; the three components are combined to reinforce the action of moistening the intestines, purging, and relaxing the bowels.
Example 13
The formula is as follows: 40g of astragalus, 20g of ginseng, 15g of angelica, 15g of bighead atractylodes rhizome, 25g of white peony root, 20g of poria cocos, 10g of ligusticum wallichii, 20g of spina gleditsiae, 10g of fructus amomi, 20g of radix puerariae, 10g of radix bupleuri, 5g of honey-fried licorice root, 10g of platycladi seed, 10g of fructus cannabis and 8g of rheum officinale. Decocting the components in water for 1-3 times (55 min each time) according to the weight ratio of the medicinal water of 1:10, and combining the decoction; concentrating the obtained decoction at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain soft extract with relative density of 1.25g/ml at 50 deg.C; drying the soft extract at 75 deg.C under vacuum degree of-0.02 to-0.06 MPa to obtain dry extract, pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding 30g dextrin, mixing, adding 60% ethanol, wet granulating, and drying to obtain granule. The formula is suitable for qi deficiency and blood stasis with the symptoms of essence deficiency and constipation; the three components are combined to reinforce the action of moistening the intestines, purging, and relaxing the bowels.
Cases of disease
Jinzhi, male, 57 years old, was injured by heavy objects to cause swelling and pain of both lower limbs for 4 hours in 3 months 4 in 2020, and was transported to his hospital by ambulance in the afternoon of the day for treatment.
When a patient is admitted, the mind is poor, the mind is clear, the swelling of the right lower limb is obvious, the skin tension is increased, the skin is scattered to be bruised and green, a 15cm L-shaped wound can be seen on the outer side of the left foot, a small amount of bleeding occurs, the movement is not good, the tenderness is obvious, the skin is warm and low, the patient can adjust the posture for the second time, the tongue is light red, the body is slightly fat, the tongue coating is white and greasy, and the pulse is wiry, thin and weak.
X-piece shows: comminuted fracture of tibial plateau of the right knee. The patient appears hemorrhagic shock promptly in the inspection process, and life sign resumes after the rescue, but the consciousness is unclear, tells family members that the patient can have life danger at any time, probably needs amputation, puts down the sick and dangerous notice book.
And (3) preliminary diagnosis: 1. right calf traumatic periosteum syndrome; 2. comminuted fracture of the tibial plateau of the right knee; 3. hemorrhagic shock. Performing right calf fasciotomy decompression, right calf necrotic muscle removal and right common peroneal nerve exploration at night. During the operation, the anterior arteriovenous rupture of the right tibia is found, the bleeding amount exceeds 3000mL, and the repair operation of the anterior arteriovenous rupture of the right tibia is carried out immediately. Post-operation supplementary diagnosis: 1. traumatic right lower limb muscle necrosis; 2. right anterior tibial artery injury; 3. injury to the right common peroneal nerve; 4. right traumatic tibiovenous injury; 5. damage to the great saphenous vein of the right lower leg.
According to the overall condition of the patient, the data is collected by the observation and the hearing of the traditional Chinese medicine, and the tongue pulse manifestation is combined,
traditional Chinese medicine diagnosis: fracture diseases; syndrome differentiation: deficiency of both qi and blood and obstruction of blood stasis.
Prescription: the invention prescription (clinical nomenclature 'Shenqi Hexue Tang', the same below)
Medicine preparation: 30g of astragalus, 15g of ginseng, 15g of angelica, 15g of bighead atractylodes rhizome, 30g of white paeony root, 30g of tuckahoe, 15g of szechuan lovage rhizome, 30g of spina gleditsiae, 10g of fructus amomi, 30g of kudzuvine root, 10g of radix bupleuri and 10g of honey-fried licorice root.
After 8 hours of operation, the ginseng and astragalus decoction is orally taken 3 times a day, 150mL each time, and is taken warmly after meals. After the three preparations are taken, the pain of the wound is relieved, the exudation of drainage fluid is reduced, the spirit is improved, the complexion is moist, the appetite is increased, the sleep is good, the stool is 1 time/day, the quantity is small, the quality is thin, the patient can feel small (the ureter is pulled out), the tongue is red and light, the coating is white, and the pulse is deep, thin and weak.
After 2 courses of treatment, the patient's condition tends to be stable, the recovery is good, and the patient is discharged from hospital. And returning half a year later, informing the patient that the lower limb functions are basically recovered, continuously walking for 1.5 hours each time, keeping the distance up to 5km, going up and down stairs, riding a bicycle for traveling and other daily activities.
According to the language: after the patient is injured by a heavy object, fracture of the right tibia, damage of the right common peroneal nerve, rupture of arteriovenous vessels and continuous bleeding of right lower limb tissues are caused, the whole compartment between fascia is filled, and huge tension is formed to press muscle tissues to cause partial muscle necrosis. The injury process causes massive hemorrhage, impairment of healthy qi, deficiency of qi and blood, and internal stagnation of blood stasis. The ginseng and astragalus decoction can tonify lung, spleen and primordial qi, and is intended to tonify qi to generate blood, accelerate qi and blood circulation, enhance metabolism and promote healing of fracture ends, muscles, common peroneal nerves, peripheral tissues and wounds. The muscles and bones and the skin are nourished by qi and blood, the bones continue to grow, the muscles grow and the skin is combined, and good functional activities are gradually recovered.
The clinical efficacy test condition of the formula 'Shenqi and Xue Tang' of the invention is described in detail as follows:
first, clinical data
1.1 sources of cases
60 selected cases are all inpatients of SuperPATH hip replacement surgery in the first subsidiary hospital of Yunnan Chinese medicine university from 2020 to 2021.
1.2 inclusion criteria
SuperPATH Artificial hip Joint replacement
B. Voluntarily as the test subject, the test subject can receive acupuncture treatment, observation and various inspectors and sign an informed consent.
1.3 exclusion criteria
A. Patients with venous thrombosis of lower limbs or other vascular diseases of lower limbs before operation
B. Before the experiment, patients who continuously use anticoagulant or antiplatelet drugs such as common heparin, low molecular heparin and the like
C. Patient with serious liver and kidney function damage before operation
D. Patients with obvious abnormal indexes of blood rheology and bleeding time before operation or patients with prothrombin activity less than 60% and platelets less than 10X 109/L.
E. Patients with cardiovascular and cerebrovascular diseases, hypertension and diabetes before operation who cannot be well controlled
F. Patients who cannot tolerate traditional Chinese medicine treatment or contraindications
G. Excessive bleeding, which refers to bleeding that can alter the course and outcome of a patient's treatment
H. Abuse of alcohol or drugs
I. Patients with cerebral hemorrhage history, active peptic ulcer, bacterial endocarditis and other medical histories within about 3 months
1.4 discontinuation of clinical trial criteria:
A. patients with Chinese medicine treatment compliance of less than 80% should be taken as rejection case to terminate clinical trial
B. Patients with severe other disease during the trial may discontinue the clinical trial of the case
C. The clinical trial of the case may be discontinued due to severe adverse events during the trial
D. Non-therapeutic reasons failed to adhere to treatment, patients who were actively withdrawn from the trial discontinued the clinical trial for that case.
1.5 study sample size
According to the report of clinical research and the clinical observation of the early stage, the Harris score of 7 days after SuperPATH approach minimally invasive hip replacement is about 65 points, and the expected Harris score of 75 points after the treatment of the radix astragali and the blood decoction; the class I error probability alpha =0.05 and the class II error probability beta =0.2 of the test are set, and 60 qualified cases meeting the inclusion criteria are planned and screened according to the sample content formula N =2{ (mu 1+ mu 2) sigma/delta }2 by adopting a double-sided test and combining practical situations, and are divided into a treatment group and a control group.
1.6 random grouping method
The randomization was used to group, select 60 cases strictly according to inclusion criteria, number 60 patients from 1,2,3 … … 60 in hospital order, and randomize the 60 patients into two groups, a treatment group (n = 30) and a control group (n = 30), using the SPSS25.0 statistical software randomizer.
Second, therapeutic index and observation method
Before and 7 days of treatment, two groups of patients respectively extract fasting venous blood to test blood sedimentation and C-reactive protein, and the results are all provided by the clinical laboratory and the central laboratory of the first subsidiary hospital of Yunnan Chinese medicine university. Before treatment, 7 days after treatment, and 30 days after treatment, the physician in charge (not knowing the group) performed the Harris score and Vas score to evaluate the pain relief degree and the functional recovery level of the patients.
Third, therapeutic methods
The patients in the treatment group are treated by oral ginseng and astragalus and blood decoction on the 1 st day after operation, and the prescription is as follows: 40g of astragalus, 15g of ginseng, 15g of angelica, 15g of bighead atractylodes rhizome, 20g of white paeony root, 20g of tuckahoe, 10g of szechuan lovage rhizome, 20g of spina gleditsiae, 10g of fructus amomi, 20g of kudzuvine root, 10g of radix bupleuri and 5g of honey-fried licorice root, and the mixture is prepared into decoction. 150 ml/time, 3 times/day, taking warm 1 hr after breakfast, lunch and supper respectively, continuously taking for 30 days, and performing postoperative conventional antiinflammatory, anticoagulation, pain relieving and nursing rehabilitation treatment;
the patients in the control group are subjected to conventional anti-inflammatory, anticoagulation, analgesia and nursing rehabilitation treatment after operation.
The decocting method comprises the following steps: decocting the medicines by a traditional Chinese medicine decoction method in a traditional Chinese medicine room of a first subsidiary hospital of Yunnan Chinese medicine university, wherein each dose is filled with 3 bags, and each bag is 150 ml.
The medicine taking method comprises the following steps: orally administering SHENQI and blood soup after breakfast, lunch and supper respectively every day, pouring the soup into a bowl, heating in a microwave oven, or pouring the soup into a milk pot, and orally administering 1 bag (150 ml) each time. And the time interval between the oral administration of the traditional Chinese medicine and the western medicine is ensured to be 1-2 hours.
Fourth, conclusion
Of the two groups of patients, the treatment group was 6 males and 19 females; control group 8 men and 16 women. The treatment groups had a minimum age of 65 years, a maximum age of 92 years, and a mean age of 77 years; the control group had a minimum age of 61 years, a maximum age of 89 years, and a mean age of 77 years. Age, BM of two groups of patientsI. The sex, affected part and basic disease are proved to have no significant difference and no statistical significance (age: t = 0.668; BMI: t = 1.413; sex: X)2= 0.523; affected part: x2= 3.432; basic diseases: x2= 0.008. There was no statistical difference in the results,P>0.05, table 1), indicating comparability for the study of packet equalization.
TABLE 1 comparison of BMI, age, sex, affected part and underlying disease
Harris score, Vas score, blood sedimentation and C-reactive protein comparison
Harris hip function score: the overall mean number of Harris scores was not statistically different before treatment (t =0.135,P= 0.893), there was a statistical difference in Harris score overall mean for 7 days of treatment: (t=5.515，P<0.001) statistical differences in Harris score population mean at 30 days of treatment: ( t =5.194，P<0.001). Treatment groups Harris score statistical differences before and after treatment: (t=20.81，P<0.001), statistical differences between control Harris scores before and after treatment: (t=17.03，P<0.001) the difference in Harris scores between the treatment group and the control group before and after treatment was statistically significant (difference 10.46, 95% CI 4.54-16.38,P<0.001）。
vas pain score: no statistical differences in the overall distribution of pre-treatment VAS scores: (Z=0.654，P= 0.513), there was a statistical difference in the overall distribution of Vas scores for 7 days of treatment: (Z=4.411，P<0.001), there was a statistical difference in the overall distribution of Vas scores for 30 days of treatment: (Z=3.233，P<0.001). Statistical differences between Vas scores in treatment groups before and after treatment: (Z=-4.455，P<0.001), statistical differences before and after treatment with the control group Vas score (Z=-4.321，P<0.001）。
C-reactive protein: statistical differences in C-reactive protein before and after treatment in treatment groups: (Z=-2.46，P=0.014）。
Blood sedimentation: the difference in the blood sedimentation values before and after treatment between the treatment group and the control group was statistically significant (difference 0.52, 95% CI 0.00-0.59,P=0.023）。
TABLE 2 Harris score, Vas score, blood sedimentation and comparison between groups after C-reactive protein treatment and comparison between groups before and after treatment
Note: there was a statistical difference in C-reactive protein before and after treatment in the treatment groups (Z = -2.46, P = 0.014).
TABLE 3 Harris score, Vas score, blood sedimentation and C-reactive protein differential comparison
TABLE 4 comparison of Chinese medicine syndrome scores of two groups of patients before and after treatment
The traditional Chinese medicine symptom scores of the two groups of patients before and after treatment are compared, the total effective rate of the treatment group is 92 percent, and the total effective rate of the control group is 79.17 percent, which shows that the curative effect of the treatment group is better than that of the control group.
Combining the above results, patients' age, BMI, sex, affected and underlying disease, and Harris, Vas score, blood sedimentation, C-reactive protein population mean and distribution before treatment were not statistically different (P>0.05) indicating comparability of the study packet balance. Statistical differences between Harris scores and Vas scores at 7 and 30 days of treatment: (P<0.05), indicating that the hip joint function recovery and pain relieving effects of the treatment group are better than those of the control group. The Harris score and the Vas score of the treatment group and the control group are statistically different before and after the treatment (P<0.05), which shows that the treatment group and the control group have the treatment effects of improving the hip joint function and relieving the pain after the femoral neck fracture operationAnd (5) effect. The difference between the Harris scores before and after treatment of the treatment group and the control group has statistical significance (P<0.05), indicating that the recovery of hip joint function in the treated group is better than that in the control group. Statistical differences in C-reactive protein before and after treatment in treatment groups: (P<0.05), indicating that the levels of C-reactive protein regulated by the ginseng and astragalus and blood decoction are better than those of the control group. The difference between the blood sedimentation values before and after the treatment of the treatment group and the control group has statistical significance (P<0.05), which shows that the blood sedimentation level of the ginseng and astragalus and the blood decoction is better than that of the control group. The control group had delayed postoperative healing for 2 cases and gastrointestinal dysfunction for 1 case, and the treatment group had no complications. The above conclusions indicate that the study is statistically significant.
The research result shows that the ginseng-astragalus-blood decoction is superior to a control group in the accelerated recovery after the femoral neck fracture operation, can effectively improve the hip joint movement function, relieve the postoperative pain, reduce the postoperative complications and regulate the level of the blood sedimentation and the C-reactive protein.
Claims (10)
1. The traditional Chinese medicine composition is suitable for qi deficiency and blood stasis type viscera dysfunction, and is composed of 30-60 g of astragalus membranaceus, 15-20 g of ginseng, 15-20 g of angelica sinensis, 10-15 g of bighead atractylodes rhizome, 15-30 g of white peony root, 20-30 g of poria cocos, 10-15 g of ligusticum wallichii, 20-30 g of spina gleditsiae, 5-10 g of fructus amomi, 15-30 g of radix puerariae, 10-15 g of radix bupleuri and 5-10 g of honey-fried licorice root by weight, and is suitable for qi deficiency and blood stasis.
2. The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction as claimed in claim 1, is characterized in that 8-12 g of pseudo-ginseng, 10-15 g of teasel root and 10-15 g of suberect spatholobus stem are added into the traditional Chinese medicine composition, and is suitable for qi deficiency and blood stasis, accompanied by blood stasis and obstruction of collaterals and flaccidity of bones and muscles; the effects of removing blood stasis, dredging collaterals and strengthening tendons and bones are achieved, and the three components are combined to strengthen the forces of promoting blood circulation, removing blood stasis, nourishing blood, stopping bleeding and tonifying liver and kidney.
3. The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction as claimed in claim 1, is characterized in that 10-15 g of rhizoma atractylodis and 8-12 g of fructus aurantii are added into the traditional Chinese medicine composition, and is suitable for qi deficiency and blood stasis, and the symptoms of transportation and transformation disorder and viscera qi obstruction; achieves the effects of activating spleen and regulating middle warmer, eliminating dampness with aromatics, and ascending and descending qi, and the two are combined to strengthen the actions of activating spleen and drying dampness, and ventilating fu-organ qi.
4. The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction as claimed in claim 1, is characterized in that 20-30 g of Chinese yam and 15-20 g of prepared rehmannia root are added in the traditional Chinese medicine composition, and is suitable for qi deficiency and blood stasis, and the symptoms of yin deficiency, fire excess and essence and blood deficiency are accompanied; achieves the efficacies of nourishing yin of heart, liver and kidney and tonifying essence and blood, and the two are used together to strengthen the power of replenishing yin essence and nourishing yin and blood.
5. The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction as claimed in claim 1, is characterized in that 8-12 g of dwarf lilyturf tuber and 10-15 g of roasted rhizoma polygonati are added in the traditional Chinese medicine composition, and is suitable for qi deficiency and blood stasis, and symptoms of spleen-lung essence deficiency and deficient fire flaming; has the effects of nourishing lung yin, benefiting stomach and promoting fluid production, and can be used for nourishing yin, lowering fire, promoting fluid production and stopping drinking.
6. The traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction as claimed in claim 1, is characterized in that 10-15 g of semen boitae, 10-15 g of fructus cannabis and 4-8 g of rhubarb are added into the traditional Chinese medicine composition, and is suitable for qi deficiency and blood stasis syndrome accompanied with essence deficiency constipation; the three components are combined to reinforce the action of moistening the intestines, purging, and relaxing the bowels.
7. A pharmaceutical preparation of the traditional Chinese medicine composition for treating qi deficiency and blood stasis type viscera dysfunction according to any one of claims 1-6, characterized in that medically acceptable auxiliary materials are added into the formula of the traditional Chinese medicine composition to prepare any one of decoction, granules, pills, tablets, capsules, paste, syrup, powder and powder.
8. The preparation of claim 7, wherein the granule is prepared by the following steps:
(1) decocting: the weight ratio of the components to the liquid medicine is 1: decocting the raw materials in water for 1-3 times, 25-30 min each time, and combining decoction liquids;
(2) concentration: concentrating the obtained decoction into thick paste at the temperature of 60-75 ℃ and the vacuum degree of-0.02 to-0.06 MPa, wherein the relative density of the thick paste at the temperature of 50-60 ℃ is 1.20-1.35 g/ml;
(3) and (3) drying: drying the thick paste into dry paste at the temperature of 60-75 ℃ and the vacuum degree of-0.02 to-0.06 MPa for later use;
(4) and (3) granulating: crushing the dry paste, sieving the crushed dry paste with a 100-mesh sieve to obtain mixed dry paste powder, adding 20-40 g of granulation auxiliary materials, uniformly mixing, adding a proper amount of 50-75% ethanol, carrying out wet granulation, and drying to obtain granules.
9. The Chinese medicinal composition preparation for treating qi deficiency and blood stasis type visceral dysfunction according to claim 6, wherein the pill is prepared by the following processes:
(1) decocting: weighing the medicinal materials in the formula according to the formula amount, and mixing the medicinal materials in a weight ratio of 1: decocting the raw materials in water for 1-3 times, each time for 25-35 min, and combining decoction liquids;
(2) concentration: concentrating the obtained decoction into thick paste at the temperature of 60-75 ℃ and the vacuum degree of-0.02 to-0.06 MPa, wherein the relative density of the thick paste at the temperature of 50-60 ℃ is 1.20-1.35 g/ml;
(3) and (3) drying: drying the thick paste at the temperature of 60-75 ℃ and the vacuum degree of-0.02-0.06 MPa to obtain dry paste for later use;
(4) pelleting: crushing the dry paste, sieving the crushed dry paste by a sieve of 100 meshes to obtain mixed dry paste powder, adding 60-80 g of pelleting auxiliary materials, uniformly mixing, and preparing pills by water or ethanol with concentration of 40% or less.
10. Use of the Chinese medicinal composition of any one of claims 1 to 9 in the preparation of a medicament for treating qi deficiency and blood stasis and/or visceral dysfunction.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720977A (en) * | 2004-07-16 | 2006-01-18 | 西安安得药业有限责任公司 | Female nutritive tonic capsule |
| CN105250864A (en) * | 2015-03-16 | 2016-01-20 | 刘芳 | Traditional Chinese medicine for treating visceral dysfunction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720977A (en) * | 2004-07-16 | 2006-01-18 | 西安安得药业有限责任公司 | Female nutritive tonic capsule |
| CN105250864A (en) * | 2015-03-16 | 2016-01-20 | 刘芳 | Traditional Chinese medicine for treating visceral dysfunction |
Non-Patent Citations (1)
| Title |
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| 林利兰: "功能失调性子宫出血的分证型临床研究", 《吉林中医药》 * |
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