CN108136053B - 用于mr分子成像的基于锰的螯合缀合物 - Google Patents

用于mr分子成像的基于锰的螯合缀合物 Download PDF

Info

Publication number
CN108136053B
CN108136053B CN201680054836.7A CN201680054836A CN108136053B CN 108136053 B CN108136053 B CN 108136053B CN 201680054836 A CN201680054836 A CN 201680054836A CN 108136053 B CN108136053 B CN 108136053B
Authority
CN
China
Prior art keywords
iii
group
alkyl
tbm
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680054836.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN108136053A (zh
Inventor
埃里克·M·盖尔
P·卡拉万
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Priority to CN202210363484.0A priority Critical patent/CN114805196A/zh
Priority to CN202210364662.1A priority patent/CN114890941A/zh
Publication of CN108136053A publication Critical patent/CN108136053A/zh
Application granted granted Critical
Publication of CN108136053B publication Critical patent/CN108136053B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/57—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C07C309/61—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C07D213/87—Hydrazides; Thio or imino analogues thereof in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Primary Health Care (AREA)
  • Medical Informatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
CN201680054836.7A 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物 Active CN108136053B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210363484.0A CN114805196A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物
CN202210364662.1A CN114890941A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562204519P 2015-08-13 2015-08-13
US62/204,519 2015-08-13
US201662356732P 2016-06-30 2016-06-30
US62/356,732 2016-06-30
PCT/US2016/046874 WO2017027834A1 (en) 2015-08-13 2016-08-12 Manganese-based chelate conjugates for molecular mr imaging

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202210363484.0A Division CN114805196A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物
CN202210364662.1A Division CN114890941A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物

Publications (2)

Publication Number Publication Date
CN108136053A CN108136053A (zh) 2018-06-08
CN108136053B true CN108136053B (zh) 2022-05-27

Family

ID=57984258

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201680054836.7A Active CN108136053B (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物
CN202210364662.1A Pending CN114890941A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物
CN202210363484.0A Pending CN114805196A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202210364662.1A Pending CN114890941A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物
CN202210363484.0A Pending CN114805196A (zh) 2015-08-13 2016-08-12 用于mr分子成像的基于锰的螯合缀合物

Country Status (6)

Country Link
US (2) US10835623B2 (enExample)
EP (1) EP3334464B1 (enExample)
JP (3) JP7523883B2 (enExample)
CN (3) CN108136053B (enExample)
ES (1) ES2987778T3 (enExample)
WO (1) WO2017027834A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2987778T3 (es) * 2015-08-13 2024-11-18 Massachusetts Gen Hospital Conjugados de quelatos a base de manganeso para la imagenología por resonancia magnética molecular
CN108888781B (zh) * 2018-06-27 2021-08-06 华东理工大学 一种超分子聚电解质胶束磁共振成像造影剂的制备方法
US11267832B2 (en) 2018-10-22 2022-03-08 The Board Of Regents Of The University Of Texas System Mn(II)-based sensors to detect zinc in vivo with MRI
CN112540095B (zh) * 2019-09-20 2022-03-22 华中农业大学 酶促低场核磁共振免疫传感器检测食源性致病菌的方法
KR20220114536A (ko) * 2019-12-17 2022-08-17 더 제너럴 하스피탈 코포레이션 고효율적인 미엘로퍼록시다제 활성형 영상화제
CN113248422B (zh) * 2020-02-10 2022-07-12 河南工业大学 一种手性α-氮杂芳烃四级碳中心类化合物、其制备方法及应用
US20230406873A1 (en) * 2020-11-17 2023-12-21 The General Hospital Corporation Probes, systems, and methods for magnetic resonance ph sensing
WO2022235769A1 (en) 2021-05-04 2022-11-10 Sachem, Inc. Strong binding metal-chelating resins using macrocycle molecules
WO2022235768A1 (en) 2021-05-04 2022-11-10 Sachem, Inc. Strong binding metal-chelating resins
WO2024086331A1 (en) * 2022-10-21 2024-04-25 The General Hospital Corporation Iron based mri probes
CN119499407A (zh) * 2024-11-25 2025-02-25 中国科学院精密测量科学与技术创新研究院 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001406A1 (de) * 1992-07-01 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr diagnostik
US6022490A (en) * 1996-06-19 2000-02-08 Lever Brothers Company Bleach activation
WO2001064660A1 (en) * 2000-03-02 2001-09-07 Mallinckrodt Inc. Novel quinoline ligands and metal complexes for diagnosis and therapy
WO2011100829A1 (en) * 2010-02-19 2011-08-25 Nordion (Canada) Inc. Bifunctional chelating agents
WO2014044916A1 (en) * 2012-09-24 2014-03-27 Qi Wang Chelates, chelating agents, conjugates derived thereof and their use
WO2014107722A1 (en) * 2013-01-07 2014-07-10 The General Hospital Corporation Manganese-based magnetic resonance contrast agents
WO2015085005A1 (en) * 2013-12-03 2015-06-11 The General Hospital Corporation Molecular imaging probes

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622420A (en) 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4899755A (en) 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4889931A (en) 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
JP2772875B2 (ja) 1991-05-14 1998-07-09 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法及び写真用漂白定着組成物
EP0713139B1 (en) * 1994-10-20 1998-06-03 Fuji Photo Film Co., Ltd. Novel, iron complex, process for producing the same, photographic processing composition and processing process using the same
JP3437013B2 (ja) * 1994-10-20 2003-08-18 富士写真フイルム株式会社 新規な鉄錯体、その製造方法、写真用処理組成物およびその処理方法
TW319763B (enExample) 1995-02-01 1997-11-11 Epix Medical Inc
DE19603033A1 (de) 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DK1154991T3 (da) 1999-02-18 2004-11-22 Univ California Salicylamid-lanthanidkomplekser til anvendelse som luminescerende markörer
AU768957B2 (en) 1999-02-18 2004-01-08 Regents Of The University Of California, The Phthalamide-lanthanide complexes for use as luminescent markers
BR0009457A (pt) * 1999-04-01 2002-01-08 Unilever Nv Composição de branqueamento, ligando, complexo de metal de transição, processo para branquear um substrato, uso de um ligando que forma um complexo com um metal de transição, processo para tratamento de um produto têxtil, e, produto têxtil seco tendo um ligando
CZ2002343A3 (cs) 1999-07-29 2002-08-14 Epix Medical, Inc. Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností
EP1203026A4 (en) 1999-07-29 2005-03-16 Dyax Corp FRACTIONS BINDING FIBRIN
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
US6869591B2 (en) 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
FR2856689A1 (fr) 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2890657B1 (fr) * 2005-09-15 2007-11-09 Commissariat Energie Atomique Procede d'obtention de complexes de lanthanides hautement luminescents.
US8034898B2 (en) 2005-12-29 2011-10-11 Collagen Medical, LLC Methods of collagen imaging
WO2008073458A2 (en) 2006-12-11 2008-06-19 Bracco Imaging S.P.A. Fibrin-binding peptides and conjugates thereof
WO2011052532A1 (ja) 2009-10-28 2011-05-05 住友化学株式会社 多座配位子金属錯体
US20140350256A1 (en) 2013-05-21 2014-11-27 University Of Southern Denmark Iron and manganese complexes comprising hexadentate monocarboxylato-containing ligands and their use for the catalysis of oxidation reactions
AR104939A1 (es) 2015-06-10 2017-08-23 Chemsenti Ltd Método oxidativo para generar dióxido de cloro
US10233205B2 (en) 2015-08-07 2019-03-19 Auburn University Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
ES2987778T3 (es) * 2015-08-13 2024-11-18 Massachusetts Gen Hospital Conjugados de quelatos a base de manganeso para la imagenología por resonancia magnética molecular

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001406A1 (de) * 1992-07-01 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr diagnostik
US6022490A (en) * 1996-06-19 2000-02-08 Lever Brothers Company Bleach activation
WO2001064660A1 (en) * 2000-03-02 2001-09-07 Mallinckrodt Inc. Novel quinoline ligands and metal complexes for diagnosis and therapy
WO2011100829A1 (en) * 2010-02-19 2011-08-25 Nordion (Canada) Inc. Bifunctional chelating agents
WO2014044916A1 (en) * 2012-09-24 2014-03-27 Qi Wang Chelates, chelating agents, conjugates derived thereof and their use
WO2014107722A1 (en) * 2013-01-07 2014-07-10 The General Hospital Corporation Manganese-based magnetic resonance contrast agents
WO2015085005A1 (en) * 2013-12-03 2015-06-11 The General Hospital Corporation Molecular imaging probes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"A Manganese Alternative to Gadolinium for MRI Contrast";Eric M Gale et al;《J. Am. Chem. Soc.》;20151120;scheme1和2 *
"A new mononuclear manganese(III) complex of an unsymmetrical hexadentate N3O3 ligand exhibiting superoxide dismutase and catalase-like activity: synthesis, characterization, properties and kinetics studies";Gabriela N. Ledesma et al;《Journal of Inorganic Biochemistry》;20150302;第146卷;第69-76页 *
"Synthesis and superoxide dismutase activity of novel iron complexes";Masakazu Tamura et al;《Journal of Organometallic Chemistry》;20001231;第611卷;第586-592页 *
Nikodem Ku znik et al."A new class of bioactivable self-immolative N,O-ligands".《European Journal of Medicinal Chemistry》.2012,第52卷 *

Also Published As

Publication number Publication date
US20190001003A1 (en) 2019-01-03
US20210015948A1 (en) 2021-01-21
EP3334464A4 (en) 2019-01-16
HK1257089A1 (en) 2019-10-11
JP2018523671A (ja) 2018-08-23
HK1253745A1 (zh) 2019-06-28
JP2024026077A (ja) 2024-02-28
CN114805196A (zh) 2022-07-29
CN108136053A (zh) 2018-06-08
CA2995210A1 (en) 2017-02-16
WO2017027834A1 (en) 2017-02-16
EP3334464A1 (en) 2018-06-20
ES2987778T3 (es) 2024-11-18
JP7482099B2 (ja) 2024-05-13
CN114890941A (zh) 2022-08-12
EP3334464B1 (en) 2024-04-10
JP2022017285A (ja) 2022-01-25
US11400171B2 (en) 2022-08-02
JP7523883B2 (ja) 2024-07-29
US10835623B2 (en) 2020-11-17

Similar Documents

Publication Publication Date Title
CN108136053B (zh) 用于mr分子成像的基于锰的螯合缀合物
KR101860160B1 (ko) 망가니즈 킬레이트 및 자기 공명 영상화 （ｍｒｉ） 조영제로서의 그의 용도
KR20020057946A (ko) 다부위 결합을 통해 멀티머 영상제를 표적화하는 방법
JP7390284B2 (ja) 鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物
Tripepi et al. Synthesis of high relaxivity gadolinium AAZTA tetramers as building blocks for bioconjugation
Chowdhury et al. Liposomal MRI probes containing encapsulated or amphiphilic Fe (III) coordination complexes
US9339563B2 (en) Contrast agents
Wacker et al. Dimer formation of GdDO3A-arylsulfonamide complexes causes loss of pH-dependency of relaxivity
JP2007521254A (ja) 診断画像用化合物
KR20240037178A (ko) Mri 조영제로서 혼합 하이드록실 펜던트를 갖는 철(iii) 매크로사이클릭 복합체
HK40078341A (en) Manganese-based chelate conjugates for molecular mr imaging
US20240285808A1 (en) Molecular probes for in vivo detection of aldehydes
HK40072595A (en) Manganese-based chelate conjugates for molecular mr imaging
Zhang et al. Effect of peptide-chelate architecture on the metabolic stability of peptide-based MRI contrast agents
CA2995210C (en) Manganese-based chelate conjugates for molecular mr imaging
HK1253745B (en) Manganese-based chelate conjugates for molecular mr imaging
HK1257089B (en) Manganese-based chelate conjugates for molecular mr imaging
WO2006121889A2 (en) Chemical exchange saturation transfer contrast agents
CZ20001189A3 (cs) Diagnostické činidlo pro monitorování intervenčních terapií

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1253745

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant