CN108136016A - 化合物和方法 - Google Patents

化合物和方法 Download PDF

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Publication number
CN108136016A
CN108136016A CN201580055883.9A CN201580055883A CN108136016A CN 108136016 A CN108136016 A CN 108136016A CN 201580055883 A CN201580055883 A CN 201580055883A CN 108136016 A CN108136016 A CN 108136016A
Authority
CN
China
Prior art keywords
cell
cells
subject
photosensitizer
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580055883.9A
Other languages
English (en)
Chinese (zh)
Inventor
A·霍格赛特
P·约翰森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PCI Biotech AS
Original Assignee
PCI Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201415247A external-priority patent/GB201415247D0/en
Priority claimed from GB201420773A external-priority patent/GB201420773D0/en
Application filed by PCI Biotech AS filed Critical PCI Biotech AS
Publication of CN108136016A publication Critical patent/CN108136016A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN201580055883.9A 2014-08-28 2015-08-28 化合物和方法 Pending CN108136016A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201415247A GB201415247D0 (en) 2014-08-28 2014-08-28 Compound and method
GB1415247.4 2014-08-28
GB1420773.2 2014-11-21
GB201420773A GB201420773D0 (en) 2014-11-21 2014-11-21 Compound and method
PCT/EP2015/069794 WO2016030529A1 (en) 2014-08-28 2015-08-28 Compound and method

Publications (1)

Publication Number Publication Date
CN108136016A true CN108136016A (zh) 2018-06-08

Family

ID=54065872

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580055883.9A Pending CN108136016A (zh) 2014-08-28 2015-08-28 化合物和方法

Country Status (9)

Country Link
US (1) US10537639B2 (https=)
EP (1) EP3185901B1 (https=)
JP (2) JP2017526371A (https=)
KR (1) KR102678732B1 (https=)
CN (1) CN108136016A (https=)
AU (1) AU2015308345B9 (https=)
BR (1) BR112017003486A2 (https=)
NZ (1) NZ729408A (https=)
WO (1) WO2016030529A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109912607A (zh) * 2018-12-11 2019-06-21 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7288951B2 (ja) 2019-02-19 2023-06-08 大塚電子株式会社 光線力学的療法条件パラメータの決定方法および光線力学的療法装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1680549A (zh) * 2004-04-06 2005-10-12 四国技术网络株式会社 抗原激发得到的树突细胞
CN102099054A (zh) * 2008-06-06 2011-06-15 贝勒研究院 呼吸道合胞病毒呈递树突细胞致耐受性
WO2013189663A1 (en) * 2012-05-15 2013-12-27 Pci Biotech As Conjugate of a photosensitiser and chitosan and uses thereof

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NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
KR100980153B1 (ko) 2000-11-29 2010-09-03 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행
AU2002230693B2 (en) 2000-12-13 2006-08-17 Immunex Corporation Method for generating immortal dendritic cell lines
GB0121023D0 (en) 2001-08-30 2001-10-24 Norwegian Radium Hospital Res Compound
ES2623812T3 (es) * 2003-11-12 2017-07-12 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Vectores a medida para tratar y prevenir cáncer pancreático
WO2005097976A1 (ja) * 2004-04-06 2005-10-20 Ehime University 抗原パルスして得られた樹状細胞
US20120269765A1 (en) 2009-07-24 2012-10-25 Garcia K Christopher Cytokine compositions and methods of use thereof
CA2906279A1 (en) * 2013-03-15 2014-09-18 Pci Biotech As A method of generating antigen presenting cells using photochemical internalisation
JP6684215B2 (ja) * 2013-08-28 2020-04-22 ピーシーアイ バイオテック エイエス 予防接種用化合物および免疫化用化合物、ならびに予防接種方法および免疫化方法
WO2015028575A1 (en) * 2013-08-28 2015-03-05 Pci Biotech As Immunisation method by photochemical internalisation
AU2014390262B2 (en) * 2014-04-11 2020-11-26 Pci Biotech As Method of treating melanoma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1680549A (zh) * 2004-04-06 2005-10-12 四国技术网络株式会社 抗原激发得到的树突细胞
CN102099054A (zh) * 2008-06-06 2011-06-15 贝勒研究院 呼吸道合胞病毒呈递树突细胞致耐受性
WO2013189663A1 (en) * 2012-05-15 2013-12-27 Pci Biotech As Conjugate of a photosensitiser and chitosan and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KEVIN S CLIVE ET AL: "Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental?", 《EXPERT REVIEW OF VACCINES》 *
MONIKA HAKERUD ET AL: "Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen", 《JOURNAL OF CONTROLLED RELEASE》 *
YING WAECKERLE-MEN ET AL: "Photochemical targeting of antigens to the cytosol for stimulation of MHC class-I-restricted T-cell responses", 《EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS》 *
孙燕 等译: "《临床肿瘤学手册》", 31 March 2001, 吉林科学技术出版社 *
赵富玺 等主编: "《医学免疫学》", 30 April 2013, 人民军医出版社 *
陈复兴 等译: "《癌症生物治疗——原理与实践》", 30 June 2005, 人民军医出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109912607A (zh) * 2018-12-11 2019-06-21 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性

Also Published As

Publication number Publication date
EP3185901C0 (en) 2023-10-04
EP3185901A1 (en) 2017-07-05
KR102678732B1 (ko) 2024-06-25
AU2015308345B9 (en) 2020-12-24
BR112017003486A2 (en) 2018-01-16
WO2016030529A1 (en) 2016-03-03
JP2017526371A (ja) 2017-09-14
CA2959207A1 (en) 2016-03-03
US20170252441A1 (en) 2017-09-07
JP2020182486A (ja) 2020-11-12
EP3185901B1 (en) 2023-10-04
KR20170047336A (ko) 2017-05-04
NZ729408A (en) 2021-12-24
US10537639B2 (en) 2020-01-21
AU2015308345B2 (en) 2020-12-10
JP7079819B2 (ja) 2022-06-02
AU2015308345A1 (en) 2017-03-16

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Application publication date: 20180608

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