CN108135466B - 相干门控无波前传感器自适应光学多光子显微以及相关系统和方法 - Google Patents

相干门控无波前传感器自适应光学多光子显微以及相关系统和方法 Download PDF

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CN108135466B
CN108135466B CN201680060550.XA CN201680060550A CN108135466B CN 108135466 B CN108135466 B CN 108135466B CN 201680060550 A CN201680060550 A CN 201680060550A CN 108135466 B CN108135466 B CN 108135466B
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oct
image
mpm
wavefront
modifying element
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CN108135466A (zh
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M·萨鲁尼克
Y·简
E·M·柯
S·博诺拉
R·J·扎瓦兹基
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Simon Fraser University
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Simon Fraser University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0016—Operational features thereof
    • A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02015—Interferometers characterised by the beam path configuration
    • G01B9/02029—Combination with non-interferometric systems, i.e. for measuring the object
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02034—Interferometers characterised by particularly shaped beams or wavefronts
    • G01B9/02038—Shaping the wavefront, e.g. generating a spherical wavefront
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02041—Interferometers characterised by particular imaging or detection techniques
    • G01B9/02044—Imaging in the frequency domain, e.g. by using a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02055—Reduction or prevention of errors; Testing; Calibration
    • G01B9/02062—Active error reduction, i.e. varying with time
    • G01B9/02067—Active error reduction, i.e. varying with time by electronic control systems, i.e. using feedback acting on optics or light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Automation & Control Theory (AREA)
  • Signal Processing (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
CN201680060550.XA 2015-09-11 2016-09-12 相干门控无波前传感器自适应光学多光子显微以及相关系统和方法 Expired - Fee Related CN108135466B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562217508P 2015-09-11 2015-09-11
US62/217,508 2015-09-11
PCT/US2016/051369 WO2017044969A1 (en) 2015-09-11 2016-09-12 Coherence-gated wavefront-sensorless adaptive-optics multi-photon microscopy, and associated systems and methods

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CN108135466A CN108135466A (zh) 2018-06-08
CN108135466B true CN108135466B (zh) 2021-07-09

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US (1) US10602925B2 (enExample)
EP (1) EP3346905A4 (enExample)
JP (1) JP2018528830A (enExample)
KR (1) KR20180059820A (enExample)
CN (1) CN108135466B (enExample)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017124545B3 (de) * 2017-10-20 2019-01-24 Carl Zeiss Meditec Ag Mikroskop
EP3594614A1 (de) * 2018-07-11 2020-01-15 Haag-Streit Ag Oct-system und oct-verfahren
CN112639582B (zh) * 2018-09-05 2024-02-23 赛莱特私人有限公司 高光谱设备和方法
JP7178228B2 (ja) * 2018-09-27 2022-11-25 株式会社トプコン 眼科撮影装置、その制御方法、プログラム、及び記録媒体
CN111122568B (zh) * 2018-11-01 2022-04-22 华中科技大学苏州脑空间信息研究院 一种高通量光学层析成像方法及成像系统
KR102143484B1 (ko) * 2018-11-12 2020-08-12 한국기초과학지원연구원 복합 현미경 시스템
EP3662812A1 (de) * 2018-12-04 2020-06-10 Haag-Streit Ag Verfahren zum durchführen einer bewegungskorrektur bei augenmessungen und messsystem
JP7188747B2 (ja) * 2018-12-05 2022-12-13 株式会社トーメーコーポレーション 眼科装置
JP7205550B2 (ja) * 2018-12-10 2023-01-17 株式会社ニコン 光学装置、及び制御装置
WO2020166465A1 (ja) * 2019-02-13 2020-08-20 キヤノン株式会社 画像処理装置、画像処理方法、及びプログラム
CN109916854B (zh) * 2019-03-27 2021-09-07 中国科学院光电技术研究所 基于相干门虚拟夏克-哈特曼波前探测技术的ao-oct成像系统与方法
CN110109244A (zh) * 2019-04-26 2019-08-09 西安理工大学 一种校正无线激光通信中畸变信号光的系统及其校正方法
CN114206200A (zh) * 2019-08-01 2022-03-18 卡尔蔡司医疗技术公司 具有k镜扫描、有效干涉测量及通过空间频率分析的瞳孔对准的眼科成像
KR102073712B1 (ko) * 2019-10-29 2020-02-05 한국기초과학지원연구원 센서리스 적응광학 시스템, 이를 적용한 이미지 장치 및 통신 장치
CN115176189A (zh) * 2019-12-24 2022-10-11 澳大利亚国立大学 激光扫描系统
CN112782844B (zh) * 2021-01-12 2023-03-31 中国科学院光电技术研究所 一种自适应光学系统稳定闭环控制方法
US12487175B2 (en) 2021-02-08 2025-12-02 Kla Corporation Three-dimensional imaging with enhanced resolution
DE102021201806A1 (de) * 2021-02-25 2022-09-08 Trumpf Laser Gmbh Verfahren und Vorrichtung zum Bestimmen eines optimierten Parametersatzes zum Durchführen einer Messung
CN116818717B (zh) * 2023-08-28 2023-11-07 泉州装备制造研究所 谱域光学相干层析成像中波长校准误差的补偿方法及系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100790417B1 (ko) * 2002-08-20 2008-01-02 호야 가부시키가이샤 광학계의 성능평가방법 및 설계방법
DE602004024193D1 (de) * 2004-08-11 2009-12-31 Max Planck Gesellschaft Verfahren und Vorrichtung zur Messung von Wellenfronten
US20060061769A1 (en) 2004-09-03 2006-03-23 California Institute Of Technology Homodyne based optical coherence microscope
JP2006081841A (ja) * 2004-09-17 2006-03-30 Topcon Corp 画像形成装置、波面補正光学装置
US8360963B2 (en) * 2006-12-22 2013-01-29 Koninklijke Philips Electronics N.V. Imaging system with two imaging modalities
WO2009039303A1 (en) * 2007-09-19 2009-03-26 State University Of New York At Stony Brook Optical coherence tomography systems and methods
JP5919628B2 (ja) * 2011-03-10 2016-05-18 ソニー株式会社 眼底イメージング装置および眼底イメージング方法
US8936364B2 (en) * 2011-10-20 2015-01-20 University Of Houston System Wavefront sensorless adaptive correction of the wave aberration for an eye
AT512216A1 (de) 2011-11-18 2013-06-15 Femtolasers Produktions Gmbh Multifunktionales lasersystem
US9101294B2 (en) * 2012-01-19 2015-08-11 Carl Zeiss Meditec, Inc. Systems and methods for enhanced accuracy in OCT imaging of the cornea
GB201217538D0 (en) * 2012-10-01 2012-11-14 Optos Plc Improvements in or relating to scanning laser ophthalmoscopes
JP6242906B2 (ja) * 2012-10-12 2017-12-06 ソルラブス、インコーポレイテッド コンパクトで低分散および低収差の補償光学走査システム
JP6178656B2 (ja) * 2013-08-02 2017-08-09 株式会社ニコン 補償光学素子の設定方法及び顕微鏡

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Multimodal In Vivo Skin Imaging with Integrated Optical Coherence and Multiphoton Microscopy;Benedikt W.Graf et al.;《IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS》;20120830;第18卷(第4期);见摘要、第Ⅱ节以及附图1 *
Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice;Yifan Jian et al.;《Biomedical Optics Express》;20140121;第5卷(第2期);见第2.1-2.2节以及附图1 *
Yifan Jian et al..Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice.《Biomedical Optics Express》.2014,第5卷(第2期),第547-559页. *

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Publication number Publication date
CA2998150A1 (en) 2017-03-16
CN108135466A (zh) 2018-06-08
US10602925B2 (en) 2020-03-31
AU2016321417A1 (en) 2018-03-29
US20180242838A1 (en) 2018-08-30
EP3346905A1 (en) 2018-07-18
JP2018528830A (ja) 2018-10-04
WO2017044969A1 (en) 2017-03-16
AU2016321417A2 (en) 2018-05-10
KR20180059820A (ko) 2018-06-05
EP3346905A4 (en) 2019-03-06

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