CN108126123A - A kind of relieving alcoholism and protecting liver composition, relieving alcoholism and protecting liver drink and preparation method and application - Google Patents
A kind of relieving alcoholism and protecting liver composition, relieving alcoholism and protecting liver drink and preparation method and application Download PDFInfo
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- CN108126123A CN108126123A CN201711473069.6A CN201711473069A CN108126123A CN 108126123 A CN108126123 A CN 108126123A CN 201711473069 A CN201711473069 A CN 201711473069A CN 108126123 A CN108126123 A CN 108126123A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
The invention belongs to functional food fields, and in particular to a kind of relieving alcoholism and protecting liver composition, relieving alcoholism and protecting liver drink and preparation method and application.The relieving alcoholism and protecting liver composition, is prepared by the following raw material component：Hoveniae semoveniae semen, flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, reed root, the fruit of glossy privet, peppermint and salt algae.The present invention also provides a kind of relieving alcoholism and protecting liver drinks containing above-mentioned composition.Wherein hoveniae semoveniae semen, flower of kudzuvine relieve the effect of alcohol Li Shui for monarch；Poria cocos, Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi, dampness removing, calming heart are minister；Peppermint liver soothing and depression relief, reed root clearing lung-heat are promoted the production of body fluid, the flat filling liver kidney of the fruit of glossy privet, are made for assistant, seven flavor medicine object collective effect based on invigorating spleen to remove dampness, takes into account the coordination of the heart, liver, spleen, lung, kidney function of five internal organs；The addition of salt algae can improve immune, vegetative cell.Each medicine shares in the present invention, can play the role of relieving alcoholism and protecting liver, Li Shui, can promote discharge of the alcohol from urine, while can also be anti-oxidant, stomach invigorating shield stomach, and then mitigates injury of the alcohol to human body.
Description
Technical field
The invention belongs to functional food fields, and in particular to a kind of relieving alcoholism and protecting liver composition, relieving alcoholism and protecting liver drink and system
Preparation Method and application.
Background technology
The traditional Chinese medical science thinks that wine, gas is warm and matter is wet.《The Yellow Emperor's Canon of Internal Medicine》Just there is the record that excessive consumption of alcohol is caused a disease,《Plain Questions ancient times day
True opinion》Cloud：" drinking liquor instead of the other beverages, leading an abnormal life instead of the normal life, sexual intercourse in drunk state, exhausting essence due to self-indulgence ... event premature senility before fifty years of age ".《Food book on Chinese herbal medicine》Note
It carries：" ... wine is to send out it, and disorderly it is clear and bright, its taste of labor.”《Longevity and Life Preservation》Described in " herbal cloud：Wine extremely hot in nature is toxic, big energy
Help fire.At a draft swallow, lung first by it, lung for the five internal organs canopy ... ... lung by crafty evil, not raw kidney water, water cannot internal heat processed, all diseases
Here is life.Its begin it is also sick shallow vomiting or spontaneous perspiration or sore scabies or nose Cha let out profit or heart splenalgia, still dissipate and go out；It is long
Also disease it is deep or to quench one's thirst, be interior subcutaneous ulcer, be consumptive lung disease, be anal fistula, being bulging, being jaundice, be blindness, be asthma, be overstrain cough, be blood
Nosebleed is top epilepsy, the disease of difficult shape, if non-brilliant, easily punishment.
As it can be seen that wine is the characteristics of causing a disease：Property heat life phlegm, first hinder lung, after involve taste, spleen soil temperature is stagnant, then soil stops up wooden strongly fragrant, liver
It loses item to reach, very then influences kidney aqueous metabolic function, therefore treat to be taken in and take into account each dirty function of lung, spleen, liver, kidney, making lung row, it is logical
The work(in water transfer road, the power of its transmitting and distributing the fluids of spleen row promote irritability tune up to smooth, kidney vital essence abundance.
As Jin Dynasty Li Dong Yuan《Treatise on the spleen and stomach》Opinion is hindered by wine, " just thinks to dissipate, sweating is then cured, next profit that woulds be better
Urine.The two is upper and lower expelling the dampness by inducing diuresis and sweating." at present for the research of disintoxicating product, mostly from the angle of sweating dampness removing, composition
The product of the upper dampness removing that mostly relieves the effect of alcohol, and the synergistic effect for hiding function is sealed to temper transportation capabilities, irritability catharsis function and kidney qi simultaneously
It studies less.
Invention content
For overcome the deficiencies in the prior art and shortcoming, primary and foremost purpose of the invention is to provide a kind of relieving alcoholism and protecting liver combination
Object, the composition include the Multiple components such as hoveniae semoveniae semen, flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, peppermint, reed root, the fruit of glossy privet, salt algae；Wherein trifoliate orange Dulcis
Son, flower of kudzuvine relieve the effect of alcohol Li Shui for monarch；Poria cocos, Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi, dampness removing, calming heart are minister；Peppermint liver soothing and depression relief, reed root clearing lung-heat life
Tianjin, the flat filling liver kidney of the fruit of glossy privet make for assistant, and seven flavor medicine object collective effect based on invigorating spleen to remove dampness, takes into account the heart, liver, spleen, lung, kidney five
The coordination of dirty function.Meanwhile salt algae is added, improve immune, vegetative cell.It is different from the current field correlative study, the group
Mechanism and feature of the object from alcoholism,alcoholic disease are closed, is combined at all times, based on sharp water invigorating the spleen, the five internal organs are simultaneously adjusted, treating both manifestation and root cause of disease.
Another object of the present invention is to provide the preparation method of above-mentioned relieving alcoholism and protecting liver composition.
It is still another object of the present invention to provide a kind of relieving alcoholism and protecting liver drink, which combines comprising above-mentioned relieving alcoholism and protecting liver
Object.
Fourth object of the present invention is to provide the application of above-mentioned relieving alcoholism and protecting liver composition and liver protecting drink of relieving the effect of alcohol.
The purpose of the present invention is achieved through the following technical solutions：
A kind of relieving alcoholism and protecting liver composition, is prepared by raw material components as follows in parts by mass：
The hoveniae semoveniae semen is southern hoveniae semoveniae semen；
The preparation method of the relieving alcoholism and protecting liver composition, comprises the following steps：
(1) after hoveniae semoveniae semen seed is crushed, 1~6h is impregnated with the water of 5~10 times of volumes, separation of solid and liquid obtains soak
With hoveniae semoveniae semen slag；The water that 5~10 times of volumes are added in hoveniae semoveniae semen slag boils 0.5~3h, and separation of solid and liquid obtains tanning liquid；It will
After soak and tanning liquid mixing, concentration obtains raisin tree seed extract；
(2) after mixing flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, reed root and the fruit of glossy privet, the water for adding in 6~12 volumes impregnates 1~6h, Gu
Liquid detaches, and obtains soak and mixing slag；Water 0.5~the 3h of tanning of 6~12 times of volumes of addition in mixing slag, separation of solid and liquid,
Obtain tanning liquid；After soak and tanning liquid are mixed, concentration obtains mixed extract；
(3) it adds in isometric cold water after fresh mint homogenate to be mixed directly, separation of solid and liquid obtains peppermint extraction
Object；
(4) after salt algae is crushed using high pressure, separation of solid and liquid obtains algae extrats；
(5) it is mixed extract, step (3) made from raisin tree seed extract made from step (1), step (2) is obtained
Algae extrats made from mint extract and step (4) mix, and obtain relieving alcoholism and protecting liver composition；
Hoveniae semoveniae semen described in step (1) is preferably southern hoveniae semoveniae semen；
The hoveniae semoveniae semen seed is preferably prepared via a method which to obtain：
Connect meat rachis in hoveniae semoveniae semen fruit maturation to take together；It is exposed to the sun after a few days, removes impurity and carpopodium, collect
Seed；Continue to spontaneously dry, grey bits are weeded out when seed is completely dried, obtain hoveniae semoveniae semen seed；
Separation of solid and liquid described in step (1) preferably filters；
Concentration described in step (1) is preferably concentrated into the 1/5~1/10 of original volume；
After flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, reed root and fruit of glossy privet mixing described in step (2), it is preferably washed with water 2~3 times again
It is impregnated；
Separation of solid and liquid described in step (2) preferably filters；
Concentration described in step (2) is preferably concentrated into the 1/5~1/10 of original volume；
Peppermint described in step (3) is purple stem purple arteries and veins type peppermint；
Fresh mint described in step (3) is preferably homogenized again after flowing water rinses；
The temperature of cold water described in step (3) is preferably 2~6 DEG C；
Separation of solid and liquid described in step (3) preferably filters；
Salt algae described in step (1) is preferably the green Dunaliella salina cell of exponential phase；
High pressure described in step (4) crushes preferably：Salt algae is mixed with water, adjustment Dunaliella salina cell weight in wet base for 80~
250g/L, then 50~100MPa high pressures crush Dunaliella salina cell；
High pressure described in step (4) crushes preferably to be carried out using high pressure cell cracker；
Separation of solid and liquid preferred embodiment described in step (4) centrifuges 4~10min for 2000~10000rpm；
Application of the relieving alcoholism and protecting liver composition in drink and field of health care products；
The relieving alcoholism and protecting liver composition preferably tea beverage, beverage made of fruits or vegetables, milk beverage, soda, solid beverage and
Application in other functional drink fields；
A kind of relieving alcoholism and protecting liver drink includes above-mentioned relieving alcoholism and protecting liver composition；
The relieving alcoholism and protecting liver drink preferably comprises following component in parts by mass：
1~10 part of relieving alcoholism and protecting liver composition；
Water supplies 100 parts；
The relieving alcoholism and protecting liver drink is also included in acid, sweetener, essence and other series food additives extremely
Few one kind；
The principle of the present invention：
Relieving alcoholism and protecting liver composition provided by the invention include hoveniae semoveniae semen, flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, peppermint, reed root, the fruit of glossy privet,
The Multiple components such as salt algae；Wherein, hoveniae semoveniae semen also known as honey raisin tree, are exactly the special medicine that relieves the effect of alcohol simply from ancient times, and acid sweet in flavor is mild-natured.The thoughts of returning home, spleen
Through, function inducing diuresis for removing edema, relieving alcoholism.《Tang materia medica》Head carries " using wood as room, then taste is thin for wine in room ".The light clear fragrance of flower of kudzuvine, property
Matter sweet and neutral.Return stomach.Function is apt to relieving alcoholism, is amusing and stomach.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Call its energy：" dizziness, the loathing of cold are controlled, high fever relieves the effect of alcohol
It is amusing, wine dysentery, diet is not thought, and chest diaphragm is glutted, and hair oh, vomits sour phlegm, and wine poison injures one's stomach, and spits blood, spitting blood, heat-clearing ".The two is in side
It is monarch drug in a prescription altogether.Poria cocos is sweet light, puts down.The thoughts of returning home, lung, spleen, kidney channel.Function clearing damp and promoting diuresis, strengthening spleen and middle warmer, antitoxic heart-soothing and sedative.For drinking
Excessively, accumulate and raw wet, the card of dampness taste, Poria cocos compatibility monarch drug in a prescription, can be amusing and stomach and dampness removing bowl spares, performance clearing damp
Turbid work(, and Poria cocos plays the role of tranquilizing the mind, and can assist wandering caused by monarch drug in a prescription treatment wine poison.Rhizoma Atractylodis Macrocephalae sweetness and bitterness temperature, returns
Spleen, lung channel.Function strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect.It is common that monarch drug in a prescription invigorating the spleen is assisted to transport wet, sharp water toxin expelling with Poria cocos compatibility, therefore in side
In be ministerial drug.Peppermint is pungent, cool.Return lung, Liver Channel.It is pungent to dissipate, the cool clear profit of energy, function wind and heat dispersing, head clearing, soothing the liver solution
Strongly fragrant, relieving sore-throat is warded off dirty.Reed root is sweet cold, enters lung, stomach, has effects that clearing heat and promoting fluid, preventing or arresting vomiting, diuresis,《Tang materia medica》Call its energy
Treatment is vomitted inverse, not lower to eat, the cards such as pathogenic heat in the stomach.All medicines are assisted with peppermint compatibility and dissipate wine poison, dispersing liver-energy, and born fluid is adjutant in side.
The fruit of glossy privet, nature and flavor are sweet, bitter, flat, return liver warp and kidney channel, have and tonify the liver and kidney, clearind deficient heat, strong waist and knee, bright knowledge, the works such as black beard and hair
With.Can harmonizing yingfen and weifen, and can coordinating the drug actions of a prescription, make medicine in Fang Zhongwei.All medicines share, heat-clearing are lifted altogether with pungent dissipate, Li Shui and invigorating the spleen
With applying, have tranquilizing the mind concurrently, head clearing, relieving sore-throat, promote the production of body fluid and other effects, treating both manifestation and root cause of disease plays the work(be amusing and relieved the effect of alcohol altogether.
The present invention is had the following advantages relative to the prior art and effect：
(1) hoveniae semoveniae semen contains the ingredients such as abundant flavonoids, polysaccharide, alkaloid and saponin(e, fatty acid, has significantly
Relieve the effect of alcohol, protect liver, anti-fibrosis, antitumor, anti-aging, calmness, analgesic effect.Meanwhile hoveniae semoveniae semen also has reduction serum
T-CHOL, triglycerides, the effect of low density lipoprotein cholesterol and enhancing glutathione reductase, glutathione mistake
The effect of the activity of oxide enzyme, superoxide dismutase and catalase.Its relieving alcoholism and protecting liver is mainly utilized in the present invention
With the effect for reducing blood fat.
(2) flower of kudzuvine contains the compositions such as flavonoids, saponins, volatile oil, sterols, alkaloid and amino acid, especially
With flavones ingredient content relatively highest, ADH, ALDH, SOD, GSH-PX vigor can be improved to have the function that it relieves the effect of alcohol,
And then fight alcoholic liver injury.Strengthen first pass effect of the ethyl alcohol in gastrointestinal tract, reduce the concentration of alcohol in blood, activate microsome
The supersession rate of oxidation of ethanol system, accelerating alcohol and its metabolite, so as to achieve the purpose that relieve the effect of alcohol.It is main in the present invention
The effect discharged using its relieving alcoholism and protecting liver and accelerating alcohol metabolism.
(3) compositions such as Poria cocos contains pachymaran and fuling triterpene class compound, play liver protection, diuresis, reducing blood lipid, increasing
The effects that strong immune, hypnosis, anti-aging.Pachymaran component can reduce the level of aquaporin 1 in kidney marrow, can significantly reduce
Blood fat disorder Serum TC, TG and LDL-C are horizontal, and it is horizontal to improve HDL-C, at the same can increased SOD, GSH-Px, reduce MDA water
It is flat.Moreover, Poria cocos acidic polysaccharose can increase the phagocytic function of macrophage in body, significantly improve immunity of organism factor IL-2,
The content of TNF-α, INF- γ, dramatically increases Thymus and spleen index.Its protect liver diuresis and raising are mainly utilized in the present invention
The effect of immunity of organisms.
(4) Rhizoma Atractylodis Macrocephalae contain volatile oil, lactone compound, polysaccharide, methods of glycosides, amino acid and other class compounds etc. into
Part, there are immunological regulation and Li Shui effects.Soluble polysaccharide can enhance mitochondrial function and inhibition by mitigating oxidative stress
Apoptosis plays the role of protecting spleen.Rhizoma Atractylodis Macrocephalae can improve spleen deficiency retention of water-damp in the body rat dysfunction of the spleen in transport situation, there is invigorating spleen for diuresis
Effect, effective substance is raw sugar component and petroleum ether component, and the effective substance of eliminate dampness and have diuretic effect is volatile oil compositions.In the present invention
In mainly using its strong spleen Li Shui and adjust stomach splenic function effect.
(5) reed root contains polysaccharide, flavonoids, Anthraquinones, phenols, steroid, small molecule phenolic acid and volatile ingredient
Multiple components are waited, the effects that liver protection, hypoglycemic and enhancing are immunized can be played.Wherein reed rhizome polysaccharide can reduce body serum AST,
ALT activity, reduces serum and Liver MDA, and increased SOD, GSH-px vigor have alt-reducing and liver-protecting, anti peroxidation of lipid
Effect.Moreover, reed root water extract can increase body endothelial system phagocytic function, have to caused by cyclophosphamide immunosupress relatively strong
Antagonism, the activity of NK cells can be enhanced, and then immune function is promoted to improve.Its protection is mainly utilized in the present invention
Effect of the liver from damaging and improving immunity of organisms.
(6) fruit of glossy privet contains oleanolic acid fruit of glossy privet acid, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, mannitol, white birch fat
The compositions such as alcohol, phosphatide, Fructus Ligustri Lucidi polysaccharide and trace element have the function of antithrombotic, improve immunity of organisms.Moreover, glossy privet
Son has significant antibacterial, antivirus action.Fruit of glossy privet decoction to staphylococcus aureus, shigella flexneri, typhoid bacillus,
Pseudomonas aeruginosa and Escherichia coli have inhibiting effect, isocratic inhibiting effect in having to Type B adenovirus.It is main in the present invention to utilize
It improves body cyclic metabolism ability and antibiosis and antiviral functions, is a kind of natural preservative ingredient.
(7) peppermint contains the effective ingredients such as volatile oil, flavonoids, organic acid, can play stimulating central nervous system, promotes
Sweat gland secretion, it is antitumor, the effects that protecting hepatic injury, anti-inflammatory and antalgic, promote Transdermal absorption.More valuable, dried peppermint leaf is to strong
The metabolic enzymes such as health mankind CYP1A2, CYP2A6, Xanthine Oxidase (XO), N-acetyltranferase-2 (NAT2)
It influences, it is found that daily ingestion of mint tea can promote the treatment of cancer by inhibiting NAT2.Its rush is mainly utilized in the present invention
Into sweat gland secretion and protect liver from the effect of damage.
(8) salt algae contains a large amount of vitamin As, beta carotene, astaxanthin, amino acid, glycerine, trace element and other battalion
Substance is supported, and the body fluid of its nutritive element content ratio and human body, cytoplasm liquid phase are coincide, be very beneficial for adjusting function of human body
Equilibrium state, " cell mobility source ", " protective agent of life " are described as by biomedical boundary, with radiation protection, delay body
Aging and anti-cancer, anticancer and other effects effect.In the present invention mainly using its electrolyte balance to body adjustment effect and
Supplement the effect of energy source.
(9) each medicine shares in the present invention, can play the role of relieving alcoholism and protecting liver, Li Shui, can promote row of the alcohol from urine
Go out, while can also be anti-oxidant, stomach invigorating shield stomach, and then mitigate injury of the alcohol to human body.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Number described in embodiment is mass parts；
Embodiment 1
(1) connect meat rachis in southern hoveniae semoveniae semen fruit maturation to take together；It is exposed to the sun after a few days, removes impurity and fruit
Handle collects southern hoveniae semoveniae semen seed；Continue to spontaneously dry, grey bits are weeded out when seed is completely dried, obtain southern hoveniae semoveniae semen seed；It will
1 part of southern hoveniae semoveniae semen seed impregnates 6h, filtering obtains soak and hoveniae semoveniae semen using after pulverizing crusher machine with the water of 5 times of volumes
Slag；The water tanning 3h of 5 times of volumes is added in hoveniae semoveniae semen slag, filtering obtains tanning liquid；After soak and tanning liquid are mixed,
The 1/10 of original volume is concentrated into using Rotary Evaporators, obtains raisin tree seed extract；
(2) 1 part of flower of kudzuvine, 1 part of Poria cocos, 1 part of Rhizoma Atractylodis Macrocephalae, 1 part of reed root and 1 portion of fruit of glossy privet are mixed, is washed with water 2 times except dedusting
Dirt and impurity etc.；Then the water for adding in 6 times of volumes impregnates 6h, and filtering obtains soak and mixing slag；6 are added in mixing slag
The water tanning 3h of times volume, filtering obtain tanning liquid；After soak and tanning liquid are mixed, concentrated using Rotary Evaporators
To the 1/10 of original volume, mixed extract is obtained；
(3) the new light violet stem purple arteries and veins type peppermint stem and leaf of large area planting base harvesting after being drained with flowing water flushing, takes 1 part
Peppermint is homogenized through refiner, and it is uniform then to add in 2 DEG C of isometric cold water mix, through gauze filtering and collecting filter liquid, obtains thin
Lotus extract；It is spare that mint extract is positioned over 4 DEG C of environment refrigerations；
(4) the fresh salt algae of green of exponential phase is collected, by 1 part of salt algae and mixing of fresh water, adjusts Dunaliella salina cell weight in wet base
For 80g/L, Dunaliella salina cell is then crushed using high pressure cell cracker, after pressure is crushed for 50MPa high pressures, 10000rpm centrifugations
4min collects supernatant, obtains algae extrats；It is spare that algae extrats are positioned over 4 DEG C of environment refrigerations；
(5) it is mixed extract, step (3) made from raisin tree seed extract made from step (1), step (2) is obtained
Algae extrats made from mint extract and step (4) mix, and obtain relieving alcoholism and protecting liver composition；
(6) 10 parts of relieving alcoholism and protecting liver composition made from step (5) is taken, any artificial color and preservative is not added, adds
Pure water is to 100 parts；By stirring, sterilizing, canned, sealing processing technology, finished product relieving alcoholism and protecting liver drink is obtained.
Embodiment 2
(1) connect meat rachis in southern hoveniae semoveniae semen fruit maturation to take together；It is exposed to the sun after a few days, removes impurity and fruit
Handle collects southern hoveniae semoveniae semen seed；Continue to spontaneously dry, grey bits are weeded out when seed is completely dried, obtain southern hoveniae semoveniae semen seed；It will
15 parts of southern hoveniae semoveniae semen seed impregnates 1h, filtering obtains soak and trifoliate orange Dulcis using after pulverizing crusher machine with the water of 10 times of volumes
Sub- slag；The water tanning 0.5h of 10 times of volumes is added in hoveniae semoveniae semen slag, filtering obtains tanning liquid；Soak and tanning liquid are mixed
After conjunction, the 1/5 of original volume is concentrated into using Rotary Evaporators, obtains raisin tree seed extract；
(2) 10 parts of flower of kudzuvine, 10 parts of Poria cocos, 10 parts of Rhizoma Atractylodis Macrocephalaes, 10 parts of reed roots and 10 portions of fruit of glossy privets are mixed, are washed with water 3 times
Except dust and impurity etc.；Then the water for adding in 12 times of volumes impregnates 1h, and filtering obtains soak and mixing slag；In mixing slag
The middle water tanning 0.5h for adding in 12 times of volumes, filtering obtain tanning liquid；After soak and tanning liquid are mixed, rotation is utilized
Evaporimeter is concentrated into the 1/5 of original volume, obtains mixed extract；
(3) the new light violet stem purple arteries and veins type peppermint stem and leaf of large area planting base harvesting after being drained with flowing water flushing, takes 5 parts
Peppermint is homogenized through refiner, and it is uniform then to add in 6 DEG C of isometric cold water mix, through gauze filtering and collecting filter liquid, obtains thin
Lotus extract；It is spare that mint extract is positioned over 4 DEG C of environment refrigerations；
(4) the fresh salt algae of green of exponential phase is collected, by 5 parts of salt algaes and mixing of fresh water, adjusts Dunaliella salina cell weight in wet base
For 100g/L, Dunaliella salina cell is then crushed using high pressure cell cracker, after pressure is crushed for 100MPa high pressures, 2000rpm from
Heart 10min collects supernatant, obtains algae extrats；It is spare that algae extrats are positioned over 4 DEG C of environment refrigerations；
(5) it is mixed extract, step (3) made from raisin tree seed extract made from step (1), step (2) is obtained
Algae extrats made from mint extract and step (4) mix, and obtain relieving alcoholism and protecting liver composition；
(6) 1 part of relieving alcoholism and protecting liver composition made from step (5) is taken, any artificial color and preservative is not added, adds pure
Water purification is to 100 parts；By stirring, sterilizing, canned, sealing processing technology, finished product relieving alcoholism and protecting liver drink is obtained.
Embodiment 3
(1) connect meat rachis in southern hoveniae semoveniae semen fruit maturation to take together；It is exposed to the sun after a few days, removes impurity and fruit
Handle collects southern hoveniae semoveniae semen seed；Continue to spontaneously dry, grey bits are weeded out when seed is completely dried, obtain southern hoveniae semoveniae semen seed；It will
7 parts of southern hoveniae semoveniae semen seed impregnates 3h, filtering obtains soak and hoveniae semoveniae semen using after pulverizing crusher machine with the water of 7 times of volumes
Slag；The water tanning 2h of 7 times of volumes is added in hoveniae semoveniae semen slag, filtering obtains tanning liquid；After soak and tanning liquid are mixed,
The 1/7 of original volume is concentrated into using Rotary Evaporators, obtains raisin tree seed extract；
(2) 5 parts of flower of kudzuvine, 5 parts of Poria cocos, 5 parts of Rhizoma Atractylodis Macrocephalaes, 5 parts of reed roots and 5 portions of fruit of glossy privets are mixed, is washed with water 3 times except dedusting
Dirt and impurity etc.；Then the water for adding in 8 times of volumes impregnates 3h, and filtering obtains soak and mixing slag；8 are added in mixing slag
The water tanning 2h of times volume, filtering obtain tanning liquid；After soak and tanning liquid are mixed, concentrated using Rotary Evaporators
To the 1/7 of original volume, mixed extract is obtained；
(3) the new light violet stem purple arteries and veins type peppermint stem and leaf of large area planting base harvesting after being drained with flowing water flushing, takes 3 parts
Peppermint is homogenized through refiner, and it is uniform then to add in 4 DEG C of isometric cold water mix, through gauze filtering and collecting filter liquid, obtains thin
Lotus extract；It is spare that mint extract is positioned over 4 DEG C of environment refrigerations；
(4) the fresh salt algae of green of exponential phase is collected, by 3 parts of salt algaes and mixing of fresh water, adjusts Dunaliella salina cell weight in wet base
For 250g/L, Dunaliella salina cell is then crushed using high pressure cell cracker, after pressure is crushed for 70MPa high pressures, 5000rpm centrifugations
6min collects supernatant, obtains algae extrats；It is spare that algae extrats are positioned over 4 DEG C of environment refrigerations；
(5) it is mixed extract, step (3) made from raisin tree seed extract made from step (1), step (2) is obtained
Algae extrats made from mint extract and step (4) mix, and obtain relieving alcoholism and protecting liver composition；
(6) 5 parts of relieving alcoholism and protecting liver composition made from step (5) is taken, any artificial color and preservative is not added, adds pure
Water purification is to 100 parts；By stirring, sterilizing, canned, sealing processing technology, finished product relieving alcoholism and protecting liver drink is obtained.
Effect example
(1) influence of the prevention administration to mouse righting reflex
Male Kunming strain mice (purchasing in commercially available company) 48,20 ± 2g of weight, 4 groups, every group are randomly divided by weight
12.It is deprived of food but not water before experiment 12 hours, model group gives physiological saline, relieving alcoholism and protecting liver composition by 0.1ml/10g gavages
High, medium and low dosage group is given the relieving alcoholism and protecting liver composition solution (solution obtained of embodiment 2 of various concentration by 0.1ml/10g gavages
Wine liver-protecting combination is mixed with water, and obtains respectively 1.572g/ml, the relieving alcoholism and protecting liver group of 0.786g/ml, 0.393g/ml
Polymer solution), after 30 minutes, by 0.15ml/10g, gavage gives Erguotou wine to each group mouse respectively.Disappeared with mouse righting reflex
It loses as observation index, i.e., is gently placed on mouse in cage for animal under, if facing upward pose gesture keeps more than 30s, then it is assumed that right
Areflexia, record mouse is from wine is filled to the latent time of righting reflex loss and the recovery time of righting reflex.
The results show that relieving alcoholism and protecting liver composition solution small dose group mouse righting reflex loss latent time has extension to become
There are shortening trend in gesture, recovery time, but not statistically significant compared with model group；Middle dose group and high dose group mouse right instead
The latent time extension that disappears is penetrated, recovery time shortens, the significant difference (P compared with model group<0.05) (table 1).
Influence of 1 prevention administration of table to mouse righting reflex
Note：Compared with model group, * P<0.05, * * P<0.01
(2) influence of the therapeutic administratp to mouse righting reflex
Male Kunming strain mice (purchasing in commercially available company) 48,20 ± 2g of weight, 4 groups, every group are randomly divided by weight
12.It is deprived of food but not water before experiment 12 hours, model group and relieves the effect of alcohol the high, medium and low dosage group of liver-protecting combination by 0.15ml/10g
Gavage gives Erguotou wine respectively, and after 30 minutes, model group gives physiological saline, relieving alcoholism and protecting liver combination by 0.1ml/10g gavages
The high, medium and low dosage group of object gives the relieving alcoholism and protecting liver composition solution of various concentration (made from embodiment 1 as 0.1ml/10g gavages
Relieving alcoholism and protecting liver composition is mixed with water, and obtains respectively 1.572g/ml, the relieving alcoholism and protecting liver of 0.786g/ml, 0.393g/ml
Composition solution), observation index is the same as the present embodiment step (1).The results show that the relieving alcoholism and protecting liver composition solution of various concentration is small
Mouse righting reflex loss latent time extends, and recovery time shortens, wherein, for high dose group compared with model group, recovery time is bright
It is aobvious to shorten, significant difference (P<0.05) (table 2).
Influence of 2 therapeutic administratp of table to mouse righting reflex
Note：Compared with model group, * P<0.05
(3) to the influence of L-AD content
Male Kunming strain mice (purchasing in commercially available company) 48,20 ± 2g of weight, 5 groups, every group are randomly divided by weight
12.It is deprived of food but not water before experiment 12 hours.In addition to blank control group, model group, the high, medium and low dosage of relieving alcoholism and protecting liver composition
Group equal 56 ° of white wine of gavage of each group mouse, 0.05ml/10g continuously give 14d, and each group mouse is fed with standard feed during modeling
It supports, free water, blank control group gives physiological saline.From the 1st day, to 1 hour after drinking, relieving alcoholism and protecting liver composition was high, in,
Low dose group is given the relieving alcoholism and protecting liver composition solution (relieving alcoholism and protecting liver made from embodiment 3 of various concentration as 0.1ml/10g gavages
Composition is mixed with water, and obtains respectively 1.572g/ml, and the relieving alcoholism and protecting liver composition of 0.786g/ml, 0.393g/ml are molten
Liquid), successive administration 14d after experiment, takes liver, lysate is added to be homogenized, and is contained using colorimetric method for determining L-AD
Amount.
The result shows that compared with model group, ADH activity increases in various concentration relieving alcoholism and protecting liver composition group Mouse Liver, has
Pole significant difference (P<0.01) righting reflex loss latent time extends, and recovery time shortens, wherein, high dose group and model
Group is compared, and recovery time is obviously shortened, significant difference (P<0.05) (table 3).
Influence of the 3 relieving alcoholism and protecting liver composition of table to mouse liver alcohol dehydrogenase content
Note：Compared with model group, * P<0.05.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of relieving alcoholism and protecting liver composition, it is characterised in that be prepared by raw material components as follows in parts by mass：
2. relieving alcoholism and protecting liver composition according to claim 1, it is characterised in that：
The hoveniae semoveniae semen is southern hoveniae semoveniae semen.
3. the preparation method of the relieving alcoholism and protecting liver composition described in claims 1 or 2, it is characterised in that comprise the following steps：
(1) after hoveniae semoveniae semen seed is crushed, 1~6h is impregnated with the water of 5~10 times of volumes, separation of solid and liquid obtains soak and trifoliate orange
Dulcis slags；The water that 5~10 times of volumes are added in hoveniae semoveniae semen slag boils 0.5~3h, and separation of solid and liquid obtains tanning liquid；It will impregnate
After liquid and tanning liquid mixing, concentration obtains raisin tree seed extract；
(2) after mixing flower of kudzuvine, Poria cocos, Rhizoma Atractylodis Macrocephalae, reed root and the fruit of glossy privet, the water for adding in 6~12 volumes impregnates 1~6h, solid-liquid point
From obtaining soak and mixing slag；The water that 6~12 times of volumes are added in mixing slag boils 0.5~3h, and separation of solid and liquid obtains
Boil liquid；After soak and tanning liquid are mixed, concentration obtains mixed extract；
(3) it adds in isometric cold water after fresh mint homogenate to be mixed directly, separation of solid and liquid obtains mint extract；
(4) after salt algae is crushed using high pressure, separation of solid and liquid obtains algae extrats；
(5) by peppermint made from mixed extract made from raisin tree seed extract made from step (1), step (2), step (3)
Algae extrats made from extract and step (4) mix, and obtain relieving alcoholism and protecting liver composition.
4. the preparation method of relieving alcoholism and protecting liver composition according to claim 3, it is characterised in that：
The hoveniae semoveniae semen seed is prepared via a method which to obtain：
Connect meat rachis in hoveniae semoveniae semen fruit maturation to take together；After being exposed to the sun, impurity and carpopodium are removed, collects seed；After
It is continuous to spontaneously dry, grey bits are weeded out when seed is completely dried, obtain hoveniae semoveniae semen seed.
5. the preparation method of relieving alcoholism and protecting liver composition according to claim 3, it is characterised in that：
Concentration described in step (1) is is concentrated into the 1/5~1/10 of original volume；
Concentration described in step (2) is is concentrated into the 1/5~1/10 of original volume.
6. the preparation method of relieving alcoholism and protecting liver composition according to claim 3, it is characterised in that：
Peppermint described in step (3) is purple stem purple arteries and veins type peppermint.
7. the preparation method of relieving alcoholism and protecting liver composition according to claim 3, it is characterised in that：
High pressure described in step (4) is broken for：Salt algae is mixed with water, adjustment Dunaliella salina cell weight in wet base is 80~250g/L, so
50~100MPa high pressures crush Dunaliella salina cell afterwards.
8. application of the relieving alcoholism and protecting liver composition in drink and field of health care products described in claims 1 or 2.
9. a kind of relieving alcoholism and protecting liver drink, it is characterised in that include the relieving alcoholism and protecting liver composition described in claims 1 or 2.
10. relieving alcoholism and protecting liver drink according to claim 9, it is characterised in that include component as follows in parts by mass：
1~10 part of relieving alcoholism and protecting liver composition；
Water supplies 100 parts.
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