CN108126013A - A kind of invigorating the spleen promotes sustained release Chinese medicine of calcium uptake and preparation method thereof and medicine congee - Google Patents
A kind of invigorating the spleen promotes sustained release Chinese medicine of calcium uptake and preparation method thereof and medicine congee Download PDFInfo
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Abstract
The present invention provides sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake and preparation method thereof and medicine congee, is related to pharmaceutical technology field.A kind of invigorating the spleen promotes the sustained release Chinese medicine of calcium uptake, including：3~5 parts of lizard, 3~5 parts of the rhizome of davallia, 3~5 parts of teasel root, 3~5 parts of frankincense, 2~4 parts of myrrh, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum, 1~3 part of corydalis tuber.Dose is few, and drug effect is notable, improves intake and uptake of the human body to calcium.A kind of invigorating the spleen promotes the preparation method of the sustained release Chinese medicine of calcium uptake, including：Lizard, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber drying, crushing are remixed.The preparation method is simple and practicable, and operability is strong, utmostly remains drug effect, is easy to industrialized production.
Description
Technical field
The present invention relates to pharmaceutical technology field, and more particularly to a kind of invigorating the spleen promotes sustained release Chinese medicine and its preparation of calcium uptake
Method and medicine congee.
Background technology
It is studied according to Chinese Soclety of Nutrition：Nationwide nutrition survey is all shown several times, other than coastal, pastoral area, I
The intake of state's most area resident's calcium is all apparent insufficient, only reaches and answers half of intake or so.That is, China occupies
The universal calcium deficiency 50% of the people.The key reason for causing universal calcium deficiency is diet.The diet of Chinese be based on plant food, this
Group food calcium content itself is just few, and oxalic acid, plant acid in food etc. has an effect on the absorption of calcium, so as to more cause calcium
Shortage.It is reported that children's calcium deficiency can cause, hypotrichosis, skeleton development are bad, are susceptible to suffer from rickets etc.；Middle-aged and the old's calcium deficiency is then
It is susceptible to suffer from osteoporosis, the risk for increasing fracture.The harm of osteoporosis maximum is easily to cause fracture, and fracture possibly even exists
Occur in the case of acutely coughing or jolt by bus.It fractures other than influencing the motor function of people, it is also possible to cause it
His complication.For example, after fracture of lumbar vertebra deformation, the digestive function of patient can be caused to decline.There are no radical cure sclerotin so far
Loose effective ways, therefore science prevention is most important.
Invention content
The purpose of the present invention is to provide the sustained release Chinese medicines that a kind of invigorating the spleen promotes calcium uptake, and dose is few, and drug effect is notable, improve
Intake and uptake of the human body to calcium.
The preparation method of sustained release Chinese medicine for promoting calcium uptake another object of the present invention is to provide a kind of invigorating the spleen, the preparation
Method is simple and practicable, and operability is strong, utmostly remains drug effect, is easy to industrialized production.
Another object of the present invention is to provide a kind of medicine congee, promote the sustained release Chinese medicine of calcium uptake including above-mentioned invigorating the spleen, have
Help intake and uptake of the human body to calcium.
The present invention is solved its technical problem and is realized using following technical scheme.
The present invention proposes that a kind of invigorating the spleen promotes the sustained release Chinese medicine of calcium uptake, counts in parts by weight, including：3~5 parts of lizard,
3~5 parts of the rhizome of davallia, 3~5 parts of teasel root, 3~5 parts of frankincense, 2~4 parts of myrrh, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum, corydalis tuber 1~
3 parts.
The present invention proposes that a kind of invigorating the spleen promotes the preparation method of the sustained release Chinese medicine of calcium uptake, including：By lizard, the rhizome of davallia,
Teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are dry, crushing remixes.
It counts in parts by weight, 3~5 parts of lizard, 3~5 parts of the rhizome of davallia, 3~5 parts of teasel root, 3~5 parts of frankincense, myrrh 2~4
Part, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum, 1~3 part of corydalis tuber.
The present invention proposes a kind of medicine congee, promotes the sustained release Chinese medicine of calcium uptake including above-mentioned invigorating the spleen.
A kind of invigorating the spleen of the embodiment of the present invention promotes the advantageous effect of the sustained release Chinese medicine of calcium uptake and preparation method thereof to be：
The present invention is according to the physiological mechanism of the traditional Chinese medical science " spleen governing muscles, bone and flesh blindly date ", using lizard, the rhizome of davallia, teasel root, breast
Perfume, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are compatible, by enhancing spleen and stomach function, promote gastrointestinal mucosa reparation, improve stomach and move
Power, and then promote absorption of the enteron aisle to the trace element such as calcium, phosphorus, while there is the continuous damage of anti-inflammatory, analgesic, improve blood calcium water
It is flat, promote the content of calcium in muscle, improve bone structure, improve and repair osteoporosis.
Two kinds of sustained-release microparticles of different sizes are made in drug by the present invention, stomach and intestine different parts absorption have it is different, so as to prolong
The mass rate of emission of drug in the gastrointestinal tract has been grown, had not only maintained Chinese medicine genuineness, but also improve the bioactivity and profit of drug
Expenditure.
Specific embodiment
Purpose, technical scheme and advantage to make the embodiment of the present invention are clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
A kind of invigorating the spleen of the embodiment of the present invention is promoted below calcium uptake sustained release Chinese medicine and preparation method thereof and medicine congee into
Row illustrates.
A kind of invigorating the spleen provided in an embodiment of the present invention promotes the sustained release Chinese medicine of calcium uptake, counts in parts by weight, including：Lizard
3~5 parts, 3~5 parts of the rhizome of davallia, 3~5 parts of teasel root, 3~5 parts of frankincense, 2~4 parts of myrrh, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum,
1~3 part of corydalis tuber.
Preferably, lizard can be 3.1 parts, 3.3 parts, 4.8 parts, 4.9 parts, the rhizome of davallia can be 3.2 parts, 3.4 parts, 4.7
Part, 4.9 parts, teasel root can be 3.2 parts, 3.4 parts, 4.7 parts, 4.9 parts, frankincense can be 3.2 parts, 3.4 parts, 4.7 parts, 4.9 parts,
Myrrh can be 2.1 parts, 2.3 parts, 3.8 parts, 3.9 parts, and Radix Notoginseng can be 2.3 parts, 3.6 parts, 3.9 parts, and cornu cerve degelatinatum can be 2.1
Part, 2.3 parts, 3.8 parts, 3.9 parts, corydalis tuber can be 1.2 parts, 1.4 parts, 2.8 parts, 2.9 parts.
Further, it in the present invention preferably embodiment, counts in parts by weight, including：3.5~4.5 parts of lizard, bone is broken
3.5~4.5 parts of benefit, 3.5~4.5 parts of teasel root, 3.5~4.5 parts of frankincense, 2.5~3.5 parts of myrrh, 2.5~3.5 parts of Radix Notoginseng, deer horn
2.5~3.5 parts of frost, 1.5~2.5 parts of corydalis tuber.
Preferably, lizard can be 3.7 parts, 3.9 parts, 4.1 parts, 4.3 parts, the rhizome of davallia can be 3.6 parts, 3.8 parts, 4.2
Part, 4.4 parts, teasel root can be 3.7 parts, 3.9 parts, 4.1 parts, 4.3 parts, frankincense can be 3.6 parts, 3.8 parts, 4.2 parts, 4.4 parts,
Myrrh can be 2.6 parts, 2.8 parts, 3.1 parts, Radix Notoginseng can be 2.7 parts, 2.9 parts, 3.3 parts, cornu cerve degelatinatum can be 2.6 parts, 2.8
Part, 3.1 parts, corydalis tuber can be 1.7 parts, 1.8 parts, 2.2 parts, 2.3 parts.
Lizard is the genuine animal drugs in Ningxia, and tail has disconnected regenerated function, for treating injury of gastrointestinal tract disease
Disease can significantly repair the gastrointestinal mucosa of damage, improve symptom of digestive tract.
The rhizome of davallia, bitter, temperature.Return liver and kidney channel.With analgesic of curing the wound, the effect of The strong bone of kidney tonifying.Modern pharmacological studies have shown that bone
Broken complementary energy increases poroma thickness, improves sclerotin healing quality；Blood calcium serum phosphorus levels can be improved, osteoblast can be activated, improve stock
The bone density of bone can prevent glucocorticoid-induced osteoporosis；Experimental study proves that Process of Total Flavonoids in Drynaria Fortunei can significantly improve the bone of rat
Density.
Teasel root, bitter, pungent, tepor.Return liver and kidney channel.With filling liver kidney, strengthening the bones and muscles, continuous the effect of fractureing.Teasel root contains carrot
Glycosides, β-sitosterol, triterpenoid saponin, sucrose, volatile oil etc..Teasel root can increase the content of poroma hydroxyproline and the content of calcium, carry
The activity and quantity of high osteoblast promote matrix calcification, promote growth of spur, accelerate the reconstruction of poroma.Pharmacological research shows
The suitable teasel root glycosides culture solution of concentration has apparent facilitation to the proliferative capacity of osteoblast.
Frankincense, pungent, bitter, temperature.The thoughts of returning home, liver, the spleen channel.With promoting blood circulation analgesic therapy, the effect of detumescence and promoting granulation.It is mainly contained in frankincense
The ingredients such as resin, natural gum.Wherein gummy calcium salt and magnesium salts containing 20% arabitic acid.It is more significant that pharmacological research proves that this product has
Analgesic and anti-inflammatory effects.Research shows that frankincense has broad-spectrum antibacterial action, but exist to the antibiotic property effect of different pathogenic bacteria certain
Otherness.
Myrrh, it is pungent, bitter, it puts down.The thoughts of returning home, liver, the spleen channel.There is scattered stasis pain, detumescence and promoting granulation.It is mainly contained in myrrh
Myrrha volatile oil, poponax resin, natural gum, a small amount of amaroid simultaneously contain the ingredients such as myrrholic acid, formic acid, acetic acid and oxidizing ferment.Pharmacology
Progress shows that Myrrha volatile oil has stronger analgesic activity.Various dosage forms, various processed products myrrh wound is caused
Mouse foot swelling have significantly or the detumescence effect of highly significant, the blood stasis dispersing and deswelling of health product myrrh act on stronger, medicine after processing
Effect is declined.
Radix Notoginseng, sweet, slight bitter, temperature.Return liver, stomach.With dissipate stasis of blood hemostasis, the effect of detumescence ding-tong.It is total to mainly contain Radix Notoginseng
Saponin(e, dencichine, flavones, volatile oil, amino acid, carbohydrate and various trace elements etc..Modern pharmacological studies have shown that the total soap of Radix Notoginseng
Glycosides is similar to acusector effect, has apparent analgesia, anti-inflammatory and immunoregulation effect.
Cornu cerve degelatinatum, sweet, salty, temperature.Return kidney, Liver Channel.With strengthening the bones and muscles, the effect of benefiting essence-blood.Cornu cerve degelatinatum main component is phosphorus
Sour calcium, calcium carbonate, nitride and colloid etc..Modern pharmacology research show cornu cerve degelatinatum can inhibit osteoclast activity, stimulation into
Bone cell proliferation, bone matrix formation increase, it is contained it is calcareous be conducive to ossific process, thus promote union.
Corydalis tuber, also referred to as corydalis tuber, pungent, bitter, temperature.Return liver, the spleen channel.With promoting blood circulation, the effect of promoting the circulation of qi, analgesic.From corydalis tuber
There are about 30 kinds, predominantly Amine quarter alkaloid for isolated composition of alkaloids.The several formulations of corydalis tuber have very strong town
Pain acts on, and the analgesia potency of total alkali is about the 40% of morphine in corydalis tuber.
The present invention is according to the physiological mechanism of the traditional Chinese medical science " spleen governing muscles, bone and flesh blindly date ", using lizard, the rhizome of davallia, teasel root, breast
Perfume, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are compatible, and lizard can improve immune as main ingredient, promote the reparation of bone injury,
Reunion of bone.The rhizome of davallia, teasel root tonify the liver and kidney, and enhance the effect of strengthening the muscles and bones.Frankincense, myrrh are as adjuvant swelling and pain relieving, work
Blood stagnation resolvation.Research confirms that the permeability promoting blood circulation and removing blood stasis that can reduce capillary reduces the exudation of inflammation and red blood cell leakage, to the greatest extent
It is early to restore local blood circulation.Radix Notoginseng, frankincense and myrrh compatibility inhibit blood viscosity in bone to increase and increase local blood flow,
Improve systemic blood rheology and sclerotin local microcirculation obstacle, accelerate metabolism, and the absorption of inflammatory seep can be accelerated,
Promote detumescence.Radix Notoginseng, corydalis tuber promoting blood circulation and stopping pain, cornu cerve degelatinatum invigorating the spleen promoting the circulation of qi.By enhancing spleen and stomach function, promote gastrointestinal mucosa reparation,
WeiDongLi Capsule is improved, and then promotes absorption of the enteron aisle to the trace element such as calcium, phosphorus, while there is the continuous damage of anti-inflammatory, analgesic, is carried
Hypercalcemia is horizontal, promotes the content of calcium in muscle, improves bone structure, improves and repairs osteoporosis, for treating and rehabilitation sclerotin
Osteoporosis.
Further, it in the present invention preferably embodiment, counts in parts by weight, raw material is：4 parts of lizard, the rhizome of davallia 4
Part, 4 parts of teasel root, 4 parts of frankincense, 3 parts of myrrh, 3 parts of Radix Notoginseng, 3 parts of cornu cerve degelatinatum, during 2 parts of corydalis tuber, drug effect is more.
Promote the preparation method of the sustained release Chinese medicine of calcium uptake the present invention also provides a kind of invigorating the spleen, including：
Raw material is weighed in proportion, including：3~5 parts of lizard, 3~5 parts of the rhizome of davallia, 3~5 parts of teasel root, 3~5 parts of frankincense do not have
2~4 parts of medicine, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum, 1~3 part of corydalis tuber.Low temperature drying after cleaning, it is in the present embodiment, dry
Temperature is 40~60 DEG C.
It is 1 in mass ratio by lizard:1~2 is divided into two parts, likewise, respectively by the rhizome of davallia, teasel root, frankincense, myrrh, three
7th, cornu cerve degelatinatum and corydalis tuber are according to 1:1~2 mass ratio is divided into two parts, totally 16 parts.By the relatively little of lizard of quality, the rhizome of davallia,
Teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mixing composition the first raw material, by the relatively more lizard of quality, the rhizome of davallia,
Teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mixing the second raw material of composition.The mass ratio of first raw material and the second raw material
It is 1:1~2.
First raw material is ground to 65~85 mesh, the second raw material is ground to 90~110 mesh.
The first raw material and the second raw material are mixed, by 1~3h of mixed raw material dry blowing, mitigates toxic side effect, enhances stomach and intestine
Nucleophilie nucleus ability.It is carried out disinfection again with Co 60, obtains sustained release Chinese medicine.
In the present invention, a variety of dosage forms can be made in sustained release Chinese medicine, such as particle, capsule.The method for preparing different dosage forms
For general method, the present invention does not limit it.In clinic, 6g is taken orally every time, and 3 times a day, old man and children take the circumstances into consideration to reduce.
Sustained release Chinese medicine provided by the invention includes two kinds of particles of different sizes, i.e., Chinese medicine is made sustained-release microparticle New-type mould
Formula fully considers that drug enters the complexity of stomach and intestine and the physiological and pathological feature of diversity and stomach and intestine, and in view of drug
Physical behavior, i.e. quality, according to drug quality difference, there is different particle, such as lizard, cornu cerve degelatinatum quality are loose, easy after crushing
It is broken, superfine powder is easily formed after processing, so being attached directly to gastric mucosa after entering stomach, curative effect can be played rapidly.And corydalis tuber, Radix Notoginseng
Etc. quality it is harder, have thick, thin different particle after processing, enter stomach and be not easy to adhere to, enteron aisle can be entered, be segmented and be sustained in enteron aisle, point
Section plays a role.Sustained-release microparticle is made in drug, since the particle size of drug differs, stomach and intestine different parts absorption have it is different,
So as to extend the mass rate of emission of drug in the gastrointestinal tract, Chinese medicine genuineness had not only been maintained, but also has improved the biological living of drug
Property and availability.By stimulating function of intestinal canal, promote intestinal absorption, improve the nutrition of bone, strengthen absorption of the bone to calcium.Granule
Type is convenient for carrying and takes.
The present invention provides a kind of medicine congee, promote the sustained release Chinese medicine of calcium uptake including above-mentioned invigorating the spleen.Above-mentioned invigorating the spleen is promoted
The sustained release Chinese medicine of calcium uptake is tuned into athero- or heating patent medicine congee is taken in milk pot.Specifically preparation method is：By dose
Invigorating the spleen promotes the sustained release Chinese medicine of calcium uptake to add in pot, is boiled with very hot oven to getting away, then use small fire instead and slowly receive congee soup to thick.
The medicine congee makes the rapid lasting performance promoting blood circulation of drug, analgesic, continuous the effects that damaging, repairing, and drug effect is apparent.And congee is made in Chinese medicine
Agent is taken, and is suitble to Chinese taste, and simple and convenient, plus-minus dose is flexible, and adaptation is wide, is easy to digest and assimilate.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake is present embodiments provided, is made by following preparation method：
Raw material is weighed in proportion, including：3 parts of lizard, 3 parts of the rhizome of davallia, 3 parts of teasel root, 3 parts of frankincense, 2 parts of myrrh, Radix Notoginseng 2
Part, 2 parts of cornu cerve degelatinatum, 1 part of corydalis tuber.It is dry under conditions of 40 DEG C after cleaning.
By lizard, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber respectively according to 1:1 mass ratio is each
It is divided into two parts, the relatively little of lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber is mixed and formed
The relatively more lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are mixed and formed by the first raw material
Second raw material.
First raw material is ground to 70 mesh, the second raw material is ground to 90 mesh.
The first raw material and the second raw material are mixed, carries out disinfection, is sustained by mixed raw material dry blowing 2h, then with Co 60
Chinese medicine.
Embodiment 2
The sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake is present embodiments provided, is made by following preparation method：
Raw material is weighed in proportion, including：5 parts of lizard, 5 parts of the rhizome of davallia, 5 parts of teasel root, 3 parts of frankincense, 4 parts of myrrh, Radix Notoginseng 2
Part, 4 parts of cornu cerve degelatinatum, 3 parts of corydalis tuber.It is dry under conditions of 50 DEG C after cleaning.
By lizard, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber respectively according to 1:2 mass ratio is each
It is divided into two parts, the relatively little of lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber is mixed and formed
The relatively more lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are mixed and formed by the first raw material
Second raw material.
First raw material is ground to 85 mesh, the second raw material is ground to 90 mesh.
The first raw material and the second raw material are mixed, carries out disinfection, is sustained by mixed raw material dry blowing 3h, then with Co 60
Chinese medicine.
Embodiment 3
The sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake is present embodiments provided, is made by following preparation method：
Raw material is weighed in proportion, including：4 parts of lizard, 4 parts of the rhizome of davallia, 4 parts of teasel root, 4 parts of frankincense, 3 parts of myrrh, Radix Notoginseng 3
Part, 3 parts of cornu cerve degelatinatum, 2 parts of corydalis tuber.It is dry under conditions of 60 DEG C after cleaning.
By lizard, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber respectively according to 1:1.5 mass ratio
It is respectively divided into two parts, by the relatively little of lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mixing group
Into the first raw material, by the relatively more lizard of quality, the rhizome of davallia, teasel root, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mixing group
Into the second raw material.
First raw material is ground to 80 mesh, the second raw material is ground to 100 mesh.
The first raw material and the second raw material are mixed, carries out disinfection, is sustained by mixed raw material dry blowing 2h, then with Co 60
Chinese medicine.
Comparative example 1
This comparative example provides the sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake, is made by following preparation method：
Raw material is weighed in proportion, including：4 parts of lizard, 4 parts of the rhizome of davallia, 4 parts of teasel root, 4 parts of frankincense, 3 parts of myrrh, Radix Notoginseng 3
Part, 3 parts of cornu cerve degelatinatum, 2 parts of corydalis tuber.
It is dry under conditions of 60 DEG C after cleaning, dried raw material mixed powder is broken to 90 mesh.By mixed raw material
1~3h of dry blowing, then carried out disinfection with Co 60, obtain sustained release Chinese medicine.
Comparative example 2
This comparative example provides the sustained release Chinese medicine that a kind of invigorating the spleen promotes calcium uptake, is made by following preparation method：
Weigh in proportion including：4 parts of frankincense, 3 parts of myrrh, 3 parts of Radix Notoginseng, 3 parts of cornu cerve degelatinatum, 2 parts of corydalis tuber.
By frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber respectively according to 1:2 mass ratio is respectively divided into two parts, by quality phase
To few frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mix composition the first raw material, by the relatively more frankincense of quality, myrrh,
Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber mixing the second raw material of composition.
First raw material is ground to 80 mesh, the second raw material is ground to 100 mesh.
The first raw material and the second raw material are mixed, carries out disinfection, obtains by 1~3h of mixed raw material dry blowing, then with Co 60
It is sustained Chinese medicine.
Comparative example 3
This comparative example provides Alendronate sodium piece.
1 zoopery of test example
1. Animal Model
10 monthly age female mice 120 is chosen, Bilateral oophorectomy shows osteoporosis after 3 months, is randomly divided into 6 groups.
2. medicine feed
It weighs the sustained release Chinese medicine that suitable Examples 1 to 3 and comparative example 1~2 provide and is dissolved in 0.5% sodium carboxymethylcellulose
In solution, the suspension of 0.15g/mL is made into, Alendronate sodium piece is crushed, is dissolved in 0.5% carboxymethylcellulose sodium solution,
It is made into the suspension of 0.15g/mL.Respectively to 1~6 group of mouse feeding Examples 1 to 3,1~3 corresponding turbid solution of comparative example.
3. experiment
After being administered 2 weeks, the bone bending strength of mouse is tested, utilizes the complete of scanning electron microscope and transmission electron microscope observing bone trabecula
Whole property and pore size.
4. result and analysis
According to experimental result, the bone bending strength for feeding the mouse of the sustained release Chinese medicine of Examples 1 to 3 offer is higher than pair
The bending strength highest of ratio 1~3, wherein 3 corresponding mouse of embodiment, the integrality of bone trabecula is also preferable, and gap is smaller, and
The bending strength of 2 corresponding mouse of comparative example 1 and comparative example is minimum, and the integrality of bone trabecula is also poor, and gap is larger.
2 clinical trial of test example
1. case is selected in
Patient of all cases source Mr. Yu's hospital diagnosis with Distal radius fracture, selected 120 patients, the age 50~
70 years old.
2. therapy
Patient per takes orally the sustained release Chinese medicine of the invigorating the spleen promotion calcium uptake of the offer of 6g embodiments 3, can be made into medicine congee clothes
With 3 times a day.
3. treatment results and analysis
Bone be crazy about x-ray scoring treatment the 4th week start relatively treatment before be obviously improved, there is fracture end positive side position in 140 patients
Piece is respectively formed side poroma, and fracture end anterioposterior and lateral film formation one or both sides poroma occur in totally 250 patients for treatment the 5th week, always
Effective percentage is up to 92.8%.And pain, swelling symptom are also substantially reduced, and the duration is also obviously shortened.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of invigorating the spleen promotes the sustained release Chinese medicine of calcium uptake, which is characterized in that it counts in parts by weight, including：3~5 parts of lizard, bone
Broken 3~5 parts of benefit, 3~5 parts of teasel root, 3~5 parts of frankincense, 2~4 parts of myrrh, 2~4 parts of Radix Notoginseng, 2~4 parts of cornu cerve degelatinatum, corydalis tuber 1~3
Part.
2. invigorating the spleen according to claim 1 promotes the sustained release Chinese medicine of calcium uptake, which is characterized in that counts, wraps in parts by weight
It includes：3.5~4.5 parts of the lizard, 3.5~4.5 parts of the rhizome of davallia, 3.5~4.5 parts of the teasel root, the frankincense 3.5~
4.5 parts, 2.5~3.5 parts of the myrrh, 2.5~3.5 parts of the Radix Notoginseng, 2.5~3.5 parts of the cornu cerve degelatinatum, the corydalis tuber 1.5
~2.5 parts.
3. invigorating the spleen according to claim 2 promotes the sustained release Chinese medicine of calcium uptake, which is characterized in that counts, wraps in parts by weight
It includes：4 parts of the lizard, 4 parts of the rhizome of davallia, 4 parts of the teasel root, 4 parts of the frankincense, 3 parts of the myrrh, 3 parts of the Radix Notoginseng,
3 parts of the cornu cerve degelatinatum, 2 parts of the corydalis tuber.
4. a kind of invigorating the spleen promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that including：By lizard, the rhizome of davallia, continue
Disconnected, frankincense, myrrh, Radix Notoginseng, cornu cerve degelatinatum and corydalis tuber are dry, crushing remixes；
It counts in parts by weight, the lizard is 3~5 parts, and the rhizome of davallia is 3~5 parts, and the teasel root is 3~5 parts, the breast
For perfume for 3~5 parts, the myrrh is 2~4 parts, and the Radix Notoginseng is 2~4 parts, and the cornu cerve degelatinatum is 2~4 parts, the member acts like a bully 1~
3 parts.
5. invigorating the spleen according to claim 4 promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that dry temperature
Spend is 40~60 DEG C.
6. invigorating the spleen according to claim 5 promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that will pass through
The dry lizard, the rhizome of davallia, the teasel root, the frankincense, the myrrh, the Radix Notoginseng, the cornu cerve degelatinatum and
The corydalis tuber is divided into the first raw material and the second raw material, and first raw material is ground to 65~85 mesh, second raw material is ground
It is milled to 90~110 mesh.
7. invigorating the spleen according to claim 6 promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that described the
The mass ratio of one raw material and second raw material is 1:1~2.
8. invigorating the spleen according to claim 4 promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that mixing is former
After material, by 1~3h of the raw material dry blowing.
9. invigorating the spleen according to claim 8 promotes the preparation method of the sustained release Chinese medicine of calcium uptake, which is characterized in that dry blowing
Afterwards, the raw material Jing Guo dry blowing is carried out disinfection with Co 60.
10. a kind of medicine congee, which is characterized in that promote the sustained release of calcium uptake including such as Claims 1 to 5 any one of them invigorating the spleen
Chinese medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038735A (en) * | 2010-12-24 | 2011-05-04 | 刘东鹏 | Traditional Chinese medicine slow-release particle lizard Gukangsan capable of accelerating fracture union |
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2018
- 2018-01-12 CN CN201810033397.2A patent/CN108126013A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038735A (en) * | 2010-12-24 | 2011-05-04 | 刘东鹏 | Traditional Chinese medicine slow-release particle lizard Gukangsan capable of accelerating fracture union |
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