CN102038735A - Traditional Chinese medicine slow-release particle lizard Gukangsan capable of accelerating fracture union - Google Patents
Traditional Chinese medicine slow-release particle lizard Gukangsan capable of accelerating fracture union Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine slow-release particle lizard Gukangsan capable of accelerating fracture union, which is prepared by mixing the following components in parts by weight: 5-3 parts of lizard, 5-3 parts of drynaria rhizome, 5-3 parts of teasel root, 5-3 parts of frankincense, 4-2 parts of myrrh, 4-2 parts of pseudo-ginseng, 4-2 parts of deer's horn deglued and 3-1 part of rhizoma corydalis. Built on the basis of clinical and experiment researches on the regenerative repair of tissues by Ningxia Multiocellated racerunner, the invention creatively adopts special animal drug in Ningxia, namely lizard which is matched with other traditional Chinese medicines, the functions of vigoration of blood circulation, renewal of loss and repair are organically combined in one formula, and the medicine is prepared into particles of different diameters. Because the size of medicine particles is different, the medicine in tiny particles firstly adheres to the gastrointestinal mucosa when entering a gastrointestinal tract so as to take effect; and medium and large particles successively enter the intestinal tract, irradiate the intestinal tract functions, and accelerate the intestinal tract to adsorb, thereby improving bone nutrition, strengthening bone union, and prolonging the release speed of the medicine in the gastrointestinal tract. Thus, the invention not only guarantees the original taste of the traditional Chinese medicine but also improves the bioactivity and availability of the medicine.
Description
Technical field
The present invention relates to a kind of Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease that promotes union of fracture.
Background technology
Along with rapid development of social economy, particularly because industry, traffic and development of high rise buildings increase the chance of causing injury.Statistics according to Beijing emergency center, 1989～1991 year traffic accident injuries account for B﹠J and damage 59% of whole causes of disease, and rose to 73% in 1989～2003 years, account for various wounds because of the first place, so damage has become that urban population causes death or one of major cause of morbidity.Fracture then is one of common clinically injury disease, in case fracture, required healing time is longer, and at this slowly in the middle of the fracture healing process, there is 5%～10% fracture that delayed union or disunion may take place again, had a strong impact on people's quality of life, brought huge misery and inconvenient to the patient.Therefore, healing time that especially how to shorten fracture at fracturing and control delayed union have just become numerous orthopaedics medical personnel problem demanding prompt solutions with disunion.
Union of fracture is the successional recovery of phalanges, and the intensity that regains bone structure is reproduced embryo's raw bone growth mode, finally recovers original bone structure and performance fully, exactly should be a kind of osteanagenesis.Along with people's going deep into to union of fracture mechanism understanding, the new method of many promotion union of fracture also produces thereupon, as application, mechanical stimulus, ultrasonic therapeutic, organizational project and the gene therapy etc. of the application of skeletal growth factor, bone transplanting, bone marrow transplantation, bone substitute.These methods have all obtained certain progress to treatment of fractures, but in clinical practice, all have certain limitation.The bone grafting wound of for example performing the operation is big, have certain risk; Gene therapy still is in the experimentation stage, and its safety, stability and tire and all do not reach satisfied effect still can not be used for clinical etc.
Doctor trained in Western medicine promotes aspect the union of fracture certain clinical efficacy is arranged at medicine, but side effect is bigger.Chinese medicine promotes that union of fracture is with a long history, curative effect is sure, and it is convenient and easy, with low cost, especially in recent years along with edge subject development such as cytobiology, molecular biology and biomechanicss, make motherland's medical science promote the research of union of fracture to rise to a new level, also show the unique advantage that it is had simultaneously in this field.Have scholar's research to show Chinese medicine by the integrally-regulated good efficacy that can reach the promotion union of fracture equally to body, and side effect is little, expense is cheap, is more suitable for clinical expansion and uses.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, a kind of accelerating bone healing is provided, and side effect is little, cheap Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease.
Technical scheme of the present invention is:
A kind of Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease that promotes union of fracture is characterized in that it being to be mixed by Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and the Rhizoma Corydalis weight proportion according to 5～3:5～3:5～3:5～3:4～2:4～2:4～2:3～1.
The present invention is dry at low temperatures with above-mentioned raw materials, make 80～100 order microgranules behind the levigation, be mixed into the sustained-release microparticle medicated diet, the microgranule that will guarantee at least 2 kinds of granularities in this process is present in the medicated diet, shine (or oven dry) for a long time by steaming (about dry blowing 2 hours) for a long time then, alleviate toxic and side effects, strengthen the gastrointestinal affinity, standby with cobalt 60 sterilization back, in clinical at different fracture patients, each oral 6g, every day 3 times, old man and child are cut down according to the circumstance, after meal furnishing medicated porridge sample or be heated into medicated porridge take that (cooking method is promptly boiled to getting away with very hot oven earlier, uses little fire again instead medicated porridge soup is slowly received to dense thick in milk pot.), make effects such as the rapid persistent performance of medicine energy is invigorated blood circulation, pain relieving, continuous damage, reparation.
The present invention is based upon on the clinical for many years and basis of experimental of the close some Eremiatis argi in Ningxia to tissue injury's Regeneration and Repair, adopt Ningxia characteristic animal pharmaceuticals---Eremiatis argi pioneeringly, and cooperate other Chinese medicine, to invigorate blood circulation, continuous decrease, repair and organically incorporate among the side, invent the fracture sustained-release microparticle---the Eremiatis argi Gukang powder medicine for treating bone disease.The present invention is physics (quality) characteristic and character, nature and flavor different according to Chinese medicine, return through, effect, cure mainly characteristics, medicine is made particle in different diameters, because drug microparticles varies in size, enter gastrointestinal tract after, the medicine that microgranule is tiny at first is attached on gastrointestinal mucosa, play a role, medium and big microgranule enters intestinal smoothly, stimulates function of intestinal canal, promotes intestinal absorption, improve the nutrition of bone, strengthen union of fracture.Because the particle size of medicine differs, be absorbed with at the gastrointestinal different parts different, thereby prolonged the mass rate of emission of medicine in gastrointestinal tract, both kept the Chinese medicine genuineness, improved the biological activity and the availability of medicine again.The present invention makes sustained-release microparticle in conjunction with the modern Chinese medicine process technology, has broken through traditional decoction mode of administration, makes gastrointestinal be easy to absorb rapid healing of fracture.
Below be concrete technical characterstic of the present invention:
1. treatment characteristics:
The traditional Chinese medical science is with a long history to the understanding of fracture, and " element asks YIN YANG classification of natural phenomena big opinion " points out " impairment of QI resulting in pain, injury of configuration resulting in swelling.The person so bitterly then swell earlier, impairment of QI resulting in injury of the configuration is also; Earlier swollen pain person then, injury of configuration resulting in impairment of QI is also ", point out in the bone injury illness, because venation is impaired, stagnation of QI and blood may bring about pain, local hemorrhage is more, the excessive skin of blood circulating out of vessels, and swelling occurs, qi depression to blood stasis is usually simultaneously and see that this is the theory of the impairment of QI-blood, one-tenth blood stasis." roman class want " preface is said: " limb injury in outside, then QI and blood is hindered in interior, battalion defends does not to some extent pass through, internal organs by discord ", point out impairment of both QI and blood after the wound, the pathomechanism of formation qi depression to blood stasis.Grasping the understanding to this pathogenesis, ancient Chinese medicine doctor has proposed to control QI and blood for earlier, blood circulation promoting and blood stasis dispelling, the basic principle of promoting tissue regeneration by removing blood stasis treatment fracture, promotion union of fracture.So Chinese medicine has application in several thousand on treatment of fractures, and has obtained outstanding achievements.Modern medicine has also adopted various different experiments means and method, carried out deep research from different perspectives, recognize that Chinese medicine has the blood supply that improves fracture site, accelerate the formation that side is propped up circulation foundation and neovascularity, promote the absorption and the machineization of local hematoma; Promote fracture site bone matrix calcium deposition; Improve the quality and the biomechanical property of callus; Improve the required micronutrient levels of union of fracture; Increase fracture local growth factor content, bring into play effects such as its usefulness.
But Eremiatis argi blood circulation promoting and dispersing pathogen accumulation among the diffusing side of the present invention can improve immunity, promotes fracture repair, and reunion of bone is as principal agent.Radix Dipsaci, Rhizoma Drynariae liver and kidney tonifying, reunion of bone strengthens its effect.Olibanum, Myrrha reducing swelling and alleviating pain, activating blood circulation to dissipate blood stasis is as accessory drugs.Studies confirm that drug for invigorating blood circulation and eliminating stasis can reduce the permeability of blood capillary, the minimizing inflammation is oozed out and erythrocyte leaks outside, and local blood circulation is recovered as early as possible.Radix Notoginseng, Olibanum, Myrrha can suppress to fracture, and the back blood viscosity raises and increase fracture regional blood flow, improves systemic blood rheology state and fracture local microcirculation obstacle, accelerates metabolism, and can quicken the absorption that inflammation is oozed out, the promotion detumescence.The disease later stage is because patient's long-term bed the card of caused by liver and kidney deficiency, weakness of the spleen and stomach, insufficiency of vital energy and blood, muscles and bones weakness can occur, so control based on liver and kidney tonifying, QI invigorating and blood producing, strong muscles and bones.Radix Notoginseng, Rhizoma Corydalis promoting blood circulation and stopping pain; Cornu Cervi Degelatinatum spleen invigorating circulation of qi promoting; Play the continuous muscle bone growth promoting of invigorating blood circulation altogether, the effect of invigorating the spleen and benefiting QI the kidney invigorating.And the present invention's process system clinical research discovery in fracture repair experimentizes from biological mechanics determining, cell and bone matrix metabolism, bone matrix calcification, bone metabolism endocrine regulation, callus microscopic morphology, microcirculation equal angles and studies and observe, and all obtains promising result.
2. medication characteristics:
Eremiatis argi: be the genuine animal drugs in Ningxia, its tail has disconnected regenerated function, is used for the treatment of the injury of gastrointestinal tract disease, can obviously repair the gastrointestinal mucosa of damage, improves symptom of digestive tract.
Rhizoma Drynariae: main effect is the kidney invigorating bone strengthening, continues and hinders pain relieving.Modern pharmacological research shows that the osteomiosis complementary energy increases callus thickness, improves the union of fracture quality; Energy increasing blood calcium serium inorganic phosphorus level can activate osteoblast, improves capital bone density, can prevent the hormonal osteoporosis; Experimentation proof Rhizoma Drynariae total flavones can obviously improve the bone density of rat.
Radix Dipsaci: main effect is invigorating the liver and kidney, bone and muscle strengthening, hemostasis, the continuous folding of curing the wound.Radix Dipsaci contains daucosterol, β-sitoesterol, triterpene saponin, sucrose, volatilization wet goods.Radix Dipsaci can promote the healing of experimental fracture and can increase the content of callus hydroxyproline and the content of calcium, improves osteoblastic activity and quantity, promotes the substrate calcification, promotes growth of spur, accelerates the reconstruction of callus.The Radix Dipsaci glycosides culture fluid that it is suitable that pharmacological research shows concentration has obvious facilitation to osteoblastic multiplication capacity.
Olibanum: have promoting blood circulation and stopping pain, the effect of detumescence and promoting granulation.Mainly contain compositions such as resin, natural gum in the Olibanum.Wherein natural gum contains the calcium salt and the magnesium salt of 20% arabitic acid.Pharmacological research proof this product has significant analgesic and anti-inflammatory effects.Studies show that Olibanum has broad-spectrum antibacterial action, but there is certain diversity in the antibiotic property effect of different pathogenic bacterium.
Myrrha: effect with promoting blood circulation and stopping pain, detumescence and promoting granulation.Mainly contain Myrrha volatile oil, poponax resin, natural gum in the Myrrha, a small amount of amaroid also contains compositions such as myrrholic acid, formic acid, acetic acid and oxidase.The pharmacological research progress shows that Myrrha volatile oil has stronger analgesic activity.The mice foot swelling that the Myrrha of various dosage forms, various processed products causes wound all has significantly or the detumescence effect of highly significant, and the blood stasis dispersing and deswelling effect of giving birth to the product Myrrha is stronger, concocts the back drug effect and descends to some extent.
Rhizoma Corydalis: invigorate blood circulation promoting the circulation of QI, analgesic effect.Separating the alkaloids composition that obtains from Rhizoma Corydalis has 30 kinds approximately, is mainly the quaternary ammonium alkaloid.The several formulations of Rhizoma Corydalis such as extractum and powder all have very strong analgesic activity, and the analgesia of total alkali is tired and is about 40% of morphine in the Rhizoma Corydalis.
Radix Notoginseng powder: have strengthening by means of tonics, removing stasis to stop bleeding, the function of subduing swelling and relieving pain.Mainly contain Radix Notoginseng total arasaponins, dencichine, flavone, volatile oil, aminoacid, saccharide and various trace element etc.Modern pharmacological research proof Radix Notoginseng total arasaponins is similar to the acusector effect, has obvious analgesia, antiinflammatory and immunoregulation effect.
Cornu Cervi Degelatinatum: the effect that kidney invigorating and YANG supporting, the hard bone of life essence-filling, marrow-benefitting are arranged.The Cornu Cervi Degelatinatum main component is calcium phosphate, calcium carbonate, nitride and colloid etc.Modern pharmacology studies show that Cornu Cervi Degelatinatum can suppress osteoclast activity, stimulating osteoblast propagation, and bone matrix forms and increases, the contained calcareous ossific process that helps, thereby promote union of fracture.
3. formulation characteristic:
The present invention makes the novel pattern of sustained-release microparticle, take into full account medicine and enter gastrointestinal complexity and multiformity, and the gastrointestinal physiological and pathological feature, and consider the physical behavior of medicine, i.e. quality, according to medicine quality difference, pulverizing back granule has different, and is loose, frangible as quality such as Eremiatis argi, Cornu Cervi Degelatinatums, the easy superfine powder that forms in processing back, so directly be attached to gastric mucosa after going into stomach, can bring into play curative effect rapidly.And quality such as Rhizoma Corydalis, Radix Notoginseng are harder, and thick, thin different microgranule is arranged after the processing, go into stomach and are difficult for adhering to, and can enter intestinal, and at intestinal segmentation slow release, segmentation plays a role.In addition Chinese medicine is made the medicated porridge agent and taken, be fit to Chinese's taste, simple and convenient, plus-minus adapts to widely flexibly, is easy to digest and assimilate.
4. therapeutical effect characteristics: experiment and the present invention of clinical research proof can promote growth of spur and union of fracture.It promotes the mechanism of union of fracture to be:
(1) improve blood circulation: the blood supply of fracture site is the key factor that influences union of fracture, and trauma fracture causes the disorderly and fracture local microcirculation obstacle of body blood rheological characteristic, directly influences the time and the quality of union of fracture.The present invention has good alleviating pain and detumescence function, and pain relieving can alleviate partial muscle spasm, and blood vessel is expanded easily, increases the local blood circulation of bone.Illustrate the Eremiatis argi Gukang powder medicine for treating bone disease by promoting the fracture site capillary network regeneration and improve the high blood coagulation state that wound causes, make broken ends of fractured bone blood for improving, for union of fracture provides nutrition and removes metabolite, thereby promote union of fracture.
(2) promote absorption of hematoma and machineization: union of fracture is finished the reparation and the reconstruction of bone by intramembranous ossification and endochondral ossification dual mode.Hematoma is an inevitably pathological product of fracture back, and organization of hematoma be os endochondrale prelude and must be through process, its machine speed affects directly that skeletonization is active to carry out.The Eremiatis argi Gukang powder medicine for treating bone disease promotes the clinical observation on the therapeutic effect of union of fracture to find: organization of hematoma is fast, and os endochondrale and intramembranous ossification are movable active, and callus occurs early.
(3) trace element supplement: the trace element that union of fracture is required, more important have zinc, calcium, magnesium, ferrum, a copper etc., zinc can strengthen alkaline phosphatase activities, make the synthetic increase of nucleic acid and albumen, manganese and ferrum can promote collagen synthetic, ferrum can improve partial pressure of oxygen and oxygen content, promotes that in early days collagen is synthetic in the callus, and middle and advanced stage promotes calcification; Copper can improve bad ammonia phthalein oxidase active, promotes the crosslinked of collagen fiber, and collagen fiber toughness is strengthened, and facilitates osteoblastic activity, helps the formation and the calcification of calcium phosphorus deposition of bone matrix, and the calcium phosphorus content is increased, and all can promote union of fracture; The synthetic trace element such as ferrum, manganese, zinc that need of bone matrix collagen participate in.In trace element detection Eremiatis argi Gukang powder medicine for treating bone disease, contain elements such as zinc, manganese, ferrum, copper, calcium, phosphorus, the patient can be by promoting trace element raising at fracture site after taking this powder, to strengthen the mobilization of trace element in the fracture end adjacent bone tissue, collagen fiber are increased, quicken callus tissue growth and calcification process.
(4) promote that glue unit is synthetic: in the fracture repair process, synthetic respectively by fibroblast, chondrocyte and osteoblast earlier, secretion substrate, substrate forms osseous tissue by the deposition of calcium salt.Thereby, manage to promote that each link of osseous tissue formation all will speed up the mineralising of bone, the process of accelerated bone tissue repair.Synthetic and the calcium deposition that promotes collagen protein during to fracture repair growth of spur and ossified important meaning arranged.Animal kind medicine Eremiatis argi in the Eremiatis argi Gukang powder medicine for treating bone disease can provide trace elements necessary and several amino acids for collagen is synthetic, brings into play it and promotes the synthetic effect of collagen.
(5) in addition, " element ask vital QI of the body connecting with natural QI opinion " says " institute of the moon gives birth to, and basis is at the five tastes, five ZANG-organs where store the vital essence, being damaged by five flavors ... carefully coordinating five kinds of flavor in foodstuff hereat, and solid skeleton and pliable tendons, QI-blood circulating regularly, amine are managed with close, sound skeleton and pure essence QI then in this way, sincerely road such as method longly have a longevity ".Above literal, the cloudy smart generation of prompting comes from the five tastes, but the five internal organs of store essential substances, again can be excessive and injured because of the diet five tastes, the mediation that is careful in one's diet can make bone honest, and the muscle arteries and veins is soft, qi and blood circulation, the amine reason is solid close, thereby recognizes that further skeleton needs the nourishing of the five tastes.Flavor is for taste, so taste are healthy and vigorous, and the skeleton of also can supplementing nutrition impels broken ends of fractured bone healing.So oneself " roman will " says Ming Xue; " card of damage swollen does not disappear, and color is constant, this asthenia of qi and blood and can not healing.When helping the strong QI and blood of taste is main " these argumentations, spell out in treatment fracture process, should note harmonizing the spleen and stomach, will do a great deal of good to union of fracture.The present invention fully takes into account gastrointestinal in this special role of fracture in healing, by stimulating function of intestinal canal, promotes intestinal absorption, improves the nutrition of bone, strengthens union of fracture, we can say that this is core of the present invention place.
5. clinical characters:
1) the present invention has obviously improved the therapeutic effect of Chinese medicine, has improved bioavailability, reduces dose, saves natural resources of Chinese medicinal materials, reduces the toxic and side effects of Chinese medicine.
2) the present invention has improved the mouthfeel of Chinese medicine in the mode of taking of medicated porridge.
3) the present invention has guaranteed the Chinese medicine genuineness, and no any additives has no side effect.
4) the present invention is applicable to miscellaneous fracture, carries, taking convenience.
5) the present invention obviously increases its dissolubility in gastrointestinal by the micronize to Chinese medicine, absorbs thereby strengthen, and extremely strong targeting is arranged.
6) the present invention has following eight effects greatly: antiinflammatory: as Olibanum, Myrrha; Pain relieving: as Rhizoma Corydalis; Invigorate blood circulation: as Radix Notoginseng; The continuous damage: as Rhizoma Drynariae, Radix Dipsaci; Promote fracture repair: as Eremiatis argi; Improve digestive tract power: Cornu Cervi Degelatinatum; Improve absorption function: Chinese medicine is made slow-releasing granules, and the medicated porridge agent is for oral administration; Trace element supplement: Radix Notoginseng, Cornu Cervi Degelatinatum.
7) the present invention detects by trace element, every 100g contains the necessary calcium 1920mg of human body, magnesium 412.7mg, ferrum 74.65mg, trace element such as zinc 5.04mg, copper 0.786mg, and necessary for human body 17 seed amino acids, it can be by promoting trace element raising at fracture site, to strengthen the mobilization of trace element in the fracture end adjacent bone tissue, collagen fiber are increased, quicken callus tissue growth and calcification process, can obviously promote union of fracture.
7. invention effect
The present invention has carried out experimentation and observation from biological mechanics determining, cell and bone matrix metabolism, bone matrix calcification, bone metabolism endocrine regulation, callus microscopic morphology, microcirculation equal angles, to promoting that union of fracture all obtains satisfied conclusion.
Below for adopting the fracture efficacy analysis test of 540 examples of Eremiatis argi Gukang powder medicine for treating bone disease treatment distal radius of the present invention:
Test method: 540 routine patients after all manual reduction is fixed, are divided into treatment at random and organize 270 examples; Take the Eremiatis argi Gukang powder medicine for treating bone disease every day, each 6g, with boiling water furnishing pasty state, took at every day 3 times in 2 hours after meal.Matched group 270 examples are taken the Radix Notoginseng tablet for curing fracture every day, and each 3, every day three times.
Result of the test: treatment group: the scoring of callus X line obviously improves before the treatment in treatment the 4th week beginning, 140 routine patients the fracture end anterioposterior and lateral film occurs and all form a side seam crust, treat the 5th week totally 250 routine patients the fracture end anterioposterior and lateral film occurs and form the one or both sides callus, total effective rate reaches 92.6%.
Matched group: the scoring of callus X line improves not obvious before treatment the 4th week beginning is than treatment, have only 10 routine patients the fracture end anterioposterior and lateral film to occur and all form a side seam crust, treat the 5th week totally 150 routine patients the fracture end anterioposterior and lateral film occurs and form the one or both sides callus, total effective rate reaches 55.6%.
Two groups relatively there were significant differences (P＜0.05).
And treatment group and matched group doing well,improving are relatively: pain, swelling symptom also obviously alleviate, and the persistent period also obviously shortens.It is little to take our effective dose, carries, taking convenience, has kept the genuineness of Chinese medicine.
The specific embodiment
Embodiment 1
At first that Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and Rhizoma Corydalis is dry at low temperatures, grind to form 80～100 purpose microgranules (guaranteeing to have at least the microgranule of two kinds of particle size diameters), then the weight proportion of above-mentioned raw materials according to 4:4:4:4:3:3:3:2 mixed, dry blowing or oven dry back about 2 hours is standby with cobalt 60 sterilization backs.
Instructions of taking: furnishing medicated porridge sample or in milk pot, be heated into medicated porridge and take that (cooking method is promptly boiled to getting away with very hot oven earlier, uses little fire again instead medicated porridge soup is slowly received to dense thick after meal.), each oral 6g, every day 3 times.
Embodiment 2
At first that Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and Rhizoma Corydalis is dry at low temperatures, grind to form 80～100 purpose microgranules (guaranteeing to have at least the microgranule of two kinds of particle size diameters), then the weight proportion of above-mentioned raw materials according to 5:3:5:3:2:2:2:1 mixed, dry blowing or oven dry back about 2 hours is standby with cobalt 60 sterilization backs.
Instructions of taking is with embodiment 1.
Embodiment 3
At first that Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and Rhizoma Corydalis is dry at low temperatures, grind to form 80～100 purpose microgranules (guaranteeing to have at least the microgranule of two kinds of particle size diameters), then the weight proportion of above-mentioned raw materials according to 3:5:3:5:4:4:4:3 mixed, dry blowing or oven dry back about 2 hours is standby with cobalt 60 sterilization backs.
Instructions of taking is with embodiment 1.
Embodiment 4
At first that Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and Rhizoma Corydalis is dry at low temperatures, grind to form 80～100 purpose microgranules (guaranteeing to have at least the microgranule of two kinds of particle size diameters), then the weight proportion of above-mentioned raw materials according to 4:5:4:5:4:3:2:1 mixed, dry blowing or oven dry back about 2 hours is standby with cobalt 60 sterilization backs.
Instructions of taking is with embodiment 1.
Claims (3)
1. a Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease that promotes union of fracture is characterized in that it being to be mixed by Eremiatis argi, Rhizoma Drynariae, Radix Dipsaci, Olibanum, Myrrha, Radix Notoginseng, Cornu Cervi Degelatinatum and the Rhizoma Corydalis weight proportion according to 5～3:5～3:5～3:5～3:4～2:4～2:4～2:3～1.
2. according to the Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease of the described promotion union of fracture of claim 1, it is characterized in that: above-mentioned all raw materials are microgranular, and its granularity is 80～100 orders.
3. according to the Chinese medicine sustained-release microparticle Eremiatis argi Gukang powder medicine for treating bone disease of the described promotion union of fracture of claim 2, it is characterized in that: above-mentioned raw materials has at least the microgranule of two kinds of granularities to exist in medicated diet.
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| CN108126013A (en) * | 2018-01-12 | 2018-06-08 | 宁夏医科大学 | A kind of invigorating the spleen promotes sustained release Chinese medicine of calcium uptake and preparation method thereof and medicine congee |
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| CN108126013A (en) * | 2018-01-12 | 2018-06-08 | 宁夏医科大学 | A kind of invigorating the spleen promotes sustained release Chinese medicine of calcium uptake and preparation method thereof and medicine congee |
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