CN108114034A - A kind of Chinese medicine composition for treating gout and preparation method thereof - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of Chinese medicine composition for treating gout according to the understanding mechanism of Chinese traditional treatment gout, each component and its mass parts ratio of the Chinese medicine composition are as follows：150~350g of radix ranunculi ternati, 150~300g of Fructus Forsythiae, 150~350g of strophanthus divaricatus, 25~100g of Chinese ephedra, 100~160g of Chinese knotweed, 100~350g of caulis lonicerae, 150~350g of scaly holly root, 50~160g of Rhizoma Atractylodis Macrocephalae, 10~40g of the Bi roots of grass, 30~70g of caulis clematidis armandii, 80~160g of corydalis tuber, 50~120g of bluish dogbane；Drug provided by the invention is a good Chinese prescription.

Description

A kind of Chinese medicine composition for treating gout and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, and in particular to a kind of Chinese medicine composition for treating gout, particularly for gout The field of the Chinese medicine composition that patient uses and preparation method thereof.

Background technology

Gout, gout are by monosodium urate salt（MSU）Crystal correlation arthropathy caused by deposition, with purine metabolic disturbance With（Or）Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic gout stone disease Disease mainly includes acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and uric acid Lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout is often with Central obesity, hyperlipidemia, hypertension, 2 types The performances such as diabetes and its its cardiovascular disease.

Clinical manifestation：

Gout is more common in middle-aged male, and women only accounts for 5%, and mainly postmenopausal women, gout have rejuvenation trend.Gout Natural history can be divided into the fourth phase, i.e., asymptomatic hyperuricemia phase, acute stage, intermittent phase, chronic phase [3].Clinical manifestation is such as Under：

1. acute gouty arthritis

Without apparent sign or only tired, general malaise and joint sting etc. before most of patients breaking-out.Typical onset is often in the late into the night It is waken up with a start due to arthralgia, the aggravation of pain progressive, up to peak when 12 is small or so, sample is bitten in tearing sample, cut sample or stinging, it is difficult to It endures.Affected joints and its its surrounding tissue is red, swollen, hot, pain and function limitation.It is interior more than a couple of days or 2 weeks voluntarily to alleviate.For the first time Breaking-out invades simple joint, and part is above to be happened at Metatarsophalangeal joint, and in the course of disease afterwards, some patientss involve it, and it should Position.Secondly it is involved, can tire out simultaneously less for joints, the joints such as shoulder, hip, backbone and temporo jaw such as instep, heel, ankle, knee, wrist and elbows And its its multiple joint, show as panarthritis.Some patientss can have the whole bodies disease such as fever, shiver with cold, headache, palpitaition and nausea Shape can be raised with white blood cell count(WBC), erythrocyte sedimentation rate (ESR) speeds and increases with c reactive protein.

2. interval stage of attack

Gout can voluntarily be alleviated after breaking-out last from days to several weeks, generally without apparent sequelae shape or leave local skin pigment Calm, furfur and its its is scratchy etc. later into the asymptomatic intermittent phase, recurs after lasting several months, several years or more than ten years, most Patient is recurred in 1 year, and more more frequently, affected joints are more and more, and symptom duration is increasingly longer.Affected joints are generally under Limb develops to upper limb, from distal end Minor articulus to large joint, occurs referring to, the joint involvements such as wrist and elbow, small number of patients can influence shoulder, Hip, sacrum ilium, chest lock or joint of vertebral column, can also involve the positions such as its its periarticular synovial bursa, tendon and stndon sheath, symptom tends to not allusion quotation Type.The small number of patients Non-intermittent phase is showed in chornic arthritis after first attack.

3. the chronic gout stone lesion phase

Subcutaneous tophus and chronic gout stone arthritis are long-term significant hyperuricemias, and a large amount of monosodium urate salt crystals are sunk Product is in the result of subcutaneous, synovium of joint, cartilage, sclerotin and its its periarticular soft tissues.The typical portion that subcutaneous tophus occurs Position is auricle, is also common in the positions such as periarticular and its its olecranon, the heel string and kneecap synovial bursa of recurrent exerbation.Appearance is subcutaneous The yellow-white neoplasm not of uniform size of protuberance, skin surface belittles, and discharges white powder or paste after ulceration, it is prolonged not More.Subcutaneous tophus is often with chronic gout stone arthritis and depositing.The intra-articular tophus largely deposited can cause joint sclerotin Destruction, periarticular tissue fibrosis and secondary degenerative change etc..Clinical manifestation be continue painful swelling of joints, tenderness, deformity and Its its dysfunction.Chronic phase symptom is opposite to be mitigated, but can also have acute attack.

4. renal lesions

（1）Chronic urate nephropathy urate crystals are deposited on renal interstitial, cause chronic one interstitial nephritis of renal tubule.Clinical table Now for urine concentrating power decline, occur enuresis nocturna increase, low-gravity urine, small molecular protein urine, leukocyturia, slight blood urine and its its Cylindruria etc..Late period can cause detection of glomeruli filtration function to decline, and renal insufficiency occur.

（2）Uric acid lithangiuria urine uric acid concentration increases in hypersaturated state, is deposited in urinary system and forms knot Stone.Incidence in patient with gout is more than 20%, thereby increases and it is possible to come across gouty arthritis occur before.Calculus smaller is in It is gritty with urine ejection, can be asymptomatic；The greater can block urinary tract, cause renal colic, blood urine, dysuria, urinary infection, Pyclectasis and ponding etc..

（3）Acute uric acid nephropathy blood and its horizontal hurried rise of its urine uric acid, it is small that a large amount of uric acid crystals are deposited on kidney Pipe, concetrated pipe etc., cause acute urinary obstruction.Clinical manifestation is oliguresis, anuria, acute renal failure；It is visible big in urine Measure uric acid crystal.Mostly by malignant tumour and its its chemicotherapy（That is tumor lysis syndrome）Cause etc. secondary reason.

So, a kind of Chinese medicine composition that can effectively treat gout how is just found, is that those skilled in the art urgently will It solves the problems, such as.

The content of the invention

With the continuous development of China's traditional Chinese medicine, in treatment gout, people gradually appreciate Chinese traditional treatment pain The advantages of wind, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment gout Present situation, the purpose of the invention is to provide a kind of Chinese medicine compositions for treating gout, recover strong early to solve patient with gout The problem of health.The drug is using common Chinese medicine as raw material, by selecting rational drug and mass parts ratio, can effectively be treated State gout.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：A kind of Chinese medicine for treating gout is provided Composition and preparation method thereof, which is characterized in that each component and mass parts of the Chinese medicine composition are than as follows：

150~350g of radix ranunculi ternati, 150~300g of Fructus Forsythiae, 150~350g of strophanthus divaricatus, 25~100g of Chinese ephedra, Chinese knotweed 100~ 160g, 100~350g of caulis lonicerae, 150~350g of scaly holly root, 50~160g of Rhizoma Atractylodis Macrocephalae, 10~40g of the Bi roots of grass, 30~70g of caulis clematidis armandii, 80~160g of corydalis tuber, 50~120g of bluish dogbane, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of Chinese medicine composition for treating gout and preparation method thereof, which is characterized in that the Chinese medicine composition it is each Component and mass parts are than as follows：

180~310g of radix ranunculi ternati, 180~260g of Fructus Forsythiae, 180~310g of strophanthus divaricatus, 30~90g of Chinese ephedra, Chinese knotweed 115~ 140g, 115~310g of caulis lonicerae, 180~310g of scaly holly root, 56~140g of Rhizoma Atractylodis Macrocephalae, 12~35g of the Bi roots of grass, 36~60g of caulis clematidis armandii, 90~140g of corydalis tuber, 56~105g of bluish dogbane, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of Chinese medicine composition for treating gout and preparation method thereof, which is characterized in that the Chinese medicine composition it is each Component and mass parts are than as follows：

Radix ranunculi ternati 280g, Fructus Forsythiae 230g, strophanthus divaricatus 280g, Chinese ephedra 80g, Chinese knotweed 120g, caulis lonicerae 280g, scaly holly root 280g, Rhizoma Atractylodis Macrocephalae 120g, Bi roots of grass 31g, caulis clematidis armandii 52g, corydalis tuber 120g, bluish dogbane 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

A kind of Chinese medicine composition for treating gout and preparation method thereof, which is characterized in that described method includes following steps It is prepared：

A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, it is ground into according to mass parts than altogether（30~50 mesh）Graininess bag It decocts；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 45min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. the mixing of secondary liquid is condensed into relative density is 1.08 clear cream, it is then dry, grind with it is after disinfection to reserve；

C, the method for 1. preparing Chinese medicine capsules according to tradition after smalls sieving ground in B, adds in suitable micro mist silicon Glue, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Its capsule it is sealed after total length be 23.3mm, medicinal powder Capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

A kind of Chinese medicine composition for treating gout and preparation method thereof, which is characterized in that the instructions of taking is：It will prepare Good capsule medicine is three times a day to take, and once a dose in the morning, afternoon and evening, dosage 2.5g（5）/ time, warm water is sent after meal Clothes.（Quit smoking during medication, wine, raw green onion, raw garlic, pungent irritable food）.26 days as a treatment course, 3~8 courses for the treatment of of taking medicine, Clinical symptoms and sign disappear, and functional activity recovers normal, obtains interim recovery from illness.

Each raw material Chinese medicine in prescription of the present invention has detailed in Chinese Pharmacopoeia, Chinese dictionary and its China's book on Chinese herbal medicine It records.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

Radix ranunculi ternati, nature and flavor：It is sweet in flavor, pungent, warm-natured, there is reducing phlegm and resolving masses, the efficacy of removing toxicity for detumescence to imitate, for treating scrofula subcutaneous nodule, malignant boil Pyogenic infections from tumour or sore, snakebite and bugbite；

Fructus Forsythiae, nature and flavor：Hardship, it is cool, there is the effect of heat-clearing, removing toxic substances, dissipating bind, detumescence, for treating warm, erysipelas, macula, large carbuncle The diseases such as pyogenic infections, scrofula, urine leaching closes；

Strophanthus divaricatus, nature and flavor：It is sour, cool in nature, there is the effect of relieving dyspepsia, clearing heat and promoting diuresis, stagnate for Therapeutic diet, hair of catching a cold Heat, jaundice with damp-heat pathogen；

Chinese ephedra, nature and flavor：Arduous, temperature, have sweating, relieving asthma, sharp water the effect of, for treat typhoid fever table is real, fever with chilliness is lossless, Headache nasal obstruction, arthralgia, cough and asthma, geomantic omen edema, difficult urination, the stupid numbness of ailment said due to cold or exposure, munbness, rubella itch；

Chinese knotweed, nature and flavor：Taste is slightly sour, micro-puckery, cool in nature, and there is clearing heat and detoxicating, dampness removing to disappear stagnant, blood-cooling itch-relieving, the work(of bright retaining screen Effect, for treating dysentery, indigestion, hepatitis, flu, tonsillitis, sphagitis, diphtheria, pertussis, nebula, mammary gland Inflammation, colpomycosis, leukorrhea, furuncle, children's warts, eczema, venomous snake bite；

Caulis lonicerae, nature and flavor：It is sweet, cold, there is the effect of clearing heat and detoxicating, dispelling wind dredging collateral, for treat warm disease heating, toxic-heat and blood stasis, Carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain；

Scaly holly root, nature and flavor：It is bitter, sweet, cold in nature, there is the effect of clearing heat and detoxicating, to promote the production of body fluid to quench thirst, for treating flu, high fever is tired of Yearningly, tonsillitis, sphagitis, tracheitis, pertussis, diarrhea, dysentery, catarrhal jaundice, wild gill fungus, arsenic intoxication；

Rhizoma Atractylodis Macrocephalae, nature and flavor：It is bitter, sweet, warm, there is the effect of air making-up and spleen enlivening, eliminate dampness and have diuretic effect, hidroschesis, tocolysis, for treating Spleen-Qi Deficiency The diseases such as weak, anorexia and loose stool, phlegm and retained fluid oedema, exterior deficiency spontaneous perspiration, fetal irritability；

The Bi roots of grass, nature and flavor：It is pungent, hot, there is the effect of warming spleen and stomach for dispelling cold, lower gas analgesic, for treating coldness and pain in the epigastrium, vomiting, diarrhea, cold The diseases such as the solidifying stagnation of the circulation of vital energy, chest impediment and cardialgia, headache, toothache；

Caulis clematidis armandii, nature and flavor：It is bitter, cold in nature, there is the effect of breast under inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, promoting menstruation, for treat stranguria, Oedema, the red, aphthae of vexed urine, Amenorrhea breast less, damp and hot numbness pain

Corydalis tuber, nature and flavor：Acrid, bitter, warm, it is nontoxic, there is promoting blood circulation, dissipate the effect of stasis of blood, qi-regulating, analgesic, for treating trusted subordinate's waist and knee All pains, irregular menstruation, abdominal mass, metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury；

Bluish dogbane, nature and flavor：It is sweet in flavor, slight bitter, cool in nature, there is the effect of The flat liver of heat-clearing, inducing diuresis for removing edema, for treating hypertension, dizzy Dizzy, headache, palpitaition, insomnia, oedema oliguria.

Drug of the present invention is the principle based on Chinese traditional treatment gout, is recognized from the pathomechanism according to gout and pharmacological action For：With regard to gout, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, there is treatment effect well to above-mentioned disease Fruit.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned gout, the drug prepared using the formula Good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific implementation of the present invention Mode is described in further detail：

Embodiment 1：

A kind of Chinese medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition are such as Shown in lower：

Radix ranunculi ternati 280g, Fructus Forsythiae 230g, strophanthus divaricatus 280g, Chinese ephedra 80g, Chinese knotweed 120g, caulis lonicerae 280g, scaly holly root 280g, Rhizoma Atractylodis Macrocephalae 120g, Bi roots of grass 31g, caulis clematidis armandii 52g, corydalis tuber 120g, bluish dogbane 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

Embodiment 2：

A kind of Chinese medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition are such as Shown in lower：

Radix ranunculi ternati 310g, Fructus Forsythiae 260g, strophanthus divaricatus 310g, Chinese ephedra 90g, Chinese knotweed 140g, caulis lonicerae 310g, scaly holly root 310g, Rhizoma Atractylodis Macrocephalae 140g, Bi roots of grass 35g, caulis clematidis armandii 60g, corydalis tuber 140g, bluish dogbane 105g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

Embodiment 3：

A kind of Chinese medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition are such as Shown in lower：

Radix ranunculi ternati 350g, Fructus Forsythiae 300g, strophanthus divaricatus 350g, Chinese ephedra 100g, Chinese knotweed 160g, caulis lonicerae 350g, scaly holly root 350g, Rhizoma Atractylodis Macrocephalae 160g, Bi roots of grass 40g, caulis clematidis armandii 70g, corydalis tuber 160g, bluish dogbane 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

Model case：

Through clinical conditions patient with gout totally 1410, the age is 855 of 53 years old or more, and only 555 are less than 53 years old. In 1410 patients Clinical symptom and sign disappear, obtain fully recover temporarily have 968, effective 372, invalid 70.Always have Efficiency is up to 95%.

Claims (3)

1. a kind of Chinese medicine composition for treating gout, which is characterized in that each component and the mass parts ratio of the Chinese medicine composition It is as follows：

150~350g of radix ranunculi ternati, 150~300g of Fructus Forsythiae, 150~350g of strophanthus divaricatus, 25~100g of Chinese ephedra, Chinese knotweed 100~ 160g, 100~350g of caulis lonicerae, 150~350g of scaly holly root, 50~160g of Rhizoma Atractylodis Macrocephalae, 10~40g of the Bi roots of grass, 30~70g of caulis clematidis armandii, 80~160g of corydalis tuber, 50~120g of bluish dogbane, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

2. it is according to claim 1 treatment gout Chinese medicine composition, which is characterized in that the Chinese medicine composition it is each Component and mass parts are than as follows：

180~310g of radix ranunculi ternati, 180~260g of Fructus Forsythiae, 180~310g of strophanthus divaricatus, 30~90g of Chinese ephedra, Chinese knotweed 115~ 140g, 115~310g of caulis lonicerae, 180~310g of scaly holly root, 56~140g of Rhizoma Atractylodis Macrocephalae, 12~35g of the Bi roots of grass, 36~60g of caulis clematidis armandii, 90~140g of corydalis tuber, 56~105g of bluish dogbane, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

3. the Chinese medicine composition of the treatment gout according to claim 1 to 2, which is characterized in that the Chinese medicine composition Each component and mass parts are than as follows：

Radix ranunculi ternati 280g, Fructus Forsythiae 230g, strophanthus divaricatus 280g, Chinese ephedra 80g, Chinese knotweed 120g, caulis lonicerae 280g, scaly holly root 280g, Rhizoma Atractylodis Macrocephalae 120g, Bi roots of grass 31g, caulis clematidis armandii 52g, corydalis tuber 120g, bluish dogbane 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.