CN108096494A - A kind of new medicine composition for treating gout and preparation method - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of new medicine composition for treating gout according to the understanding mechanism of Chinese traditional treatment gout, each component and its mass parts ratio of the Chinese medicine composition are as follows：150~350g of claws of a hawk maple, 100~160g of pueraria lobata, 150~300g of berba aristolochiae mollissimae, 50~160g of Radix Salviae Miltiorrhizae, 50~160g of Radix Angelicae Sinensis, 100~350g of caulis lonicerae, 30~120g of Rhizoma Et Radix Notopterygii, 150~550g of coix seed, 30~120g of Radix Angelicae Pubescentis, 100~160g of plantain seed, 50~160g of sargentodoxa cuneata, 100~350g of yellow Stilbene, 150~300g of Caulis Spatholobi, 50~100g of radix cynanchi atrati；Drug provided by the invention is a good Chinese prescription.

Description

A kind of new medicine composition for treating gout and preparation method

Technical field

The invention belongs to field of traditional Chinese, and in particular to a kind of new medicine composition for treating gout particularly supplies The new medicine composition and the field of preparation method that patient with gout uses.

Background technology

Doctor thinks：Gout is by monosodium urate salt（MSU）Crystal correlation arthropathy caused by deposition, with purine metabolism It is disorderly and（Or）Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic gout Stone disease mainly includes acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and urine Acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout often with Central obesity, hyperlipidemia, hypertension, The performances such as diabetes B and its its cardiovascular disease.

Gout is more common in middle-aged male, and women only accounts for 5%, and mainly postmenopausal women, gout have rejuvenation trend. The natural history of gout can be divided into the fourth phase, i.e., asymptomatic hyperuricemia phase, acute stage, intermittent phase, chronic phase [3].It is clinical Performance is as follows：

1. acute gouty arthritis

Without apparent sign or only tired, general malaise and joint sting etc. before most of patients breaking-out.Typical onset is often in the late into the night It is waken up with a start due to arthralgia, the aggravation of pain progressive, up to peak when 12 is small or so, sample is bitten in tearing sample, cut sample or stinging, it is difficult to It endures.Affected joints and its its surrounding tissue is red, swollen, hot, pain and function limitation.It is interior more than a couple of days or 2 weeks voluntarily to alleviate.For the first time Breaking-out invades simple joint, and part is above to be happened at Metatarsophalangeal joint, and in the course of disease afterwards, some patientss involve it, and it should Position.Secondly it is involved, can tire out simultaneously less for joints, the joints such as shoulder, hip, backbone and temporo jaw such as instep, heel, ankle, knee, wrist and elbows And its its multiple joint, show as panarthritis.Some patientss can have the whole bodies disease such as fever, shiver with cold, headache, palpitaition and nausea Shape can be raised with white blood cell count(WBC), erythrocyte sedimentation rate (ESR) speeds and increases with c reactive protein.

2. interval stage of attack

Gout can voluntarily be alleviated after breaking-out last from days to several weeks, generally without apparent sequelae shape or leave local skin pigment Calm, furfur and its its is scratchy etc. later into the asymptomatic intermittent phase, recurs after lasting several months, several years or more than ten years, most Patient is recurred in 1 year, and more more frequently, affected joints are more and more, and symptom duration is increasingly longer.Affected joints are generally under Limb develops to upper limb, from distal end Minor articulus to large joint, occurs referring to, the joint involvements such as wrist and elbow, small number of patients can influence shoulder, Hip, sacrum ilium, chest lock or joint of vertebral column, can also involve the positions such as its its periarticular synovial bursa, tendon and stndon sheath, symptom tends to not allusion quotation Type.The small number of patients Non-intermittent phase is showed in chornic arthritis after first attack.

3. the chronic gout stone lesion phase

Subcutaneous tophus and chronic gout stone arthritis are long-term significant hyperuricemias, and a large amount of monosodium urate salt crystals are sunk Product is in the result of subcutaneous, synovium of joint, cartilage, sclerotin and its its periarticular soft tissues.The typical portion that subcutaneous tophus occurs Position is auricle, is also common in the positions such as periarticular and its its olecranon, the heel string and kneecap synovial bursa of recurrent exerbation.Appearance is subcutaneous The yellow-white neoplasm not of uniform size of protuberance, skin surface belittles, and discharges white powder or paste after ulceration, it is prolonged not More.Subcutaneous tophus is often with chronic gout stone arthritis and depositing.The intra-articular tophus largely deposited can cause joint sclerotin Destruction, periarticular tissue fibrosis and secondary degenerative change etc..Clinical manifestation be continue painful swelling of joints, tenderness, deformity and Its its dysfunction.Chronic phase symptom is opposite to be mitigated, but can also have acute attack.

4. renal lesions

（1）Chronic urate nephropathy urate crystals are deposited on renal interstitial, cause chronic one interstitial nephritis of renal tubule.Clinical table Now for urine concentrating power decline, occur enuresis nocturna increase, low-gravity urine, small molecular protein urine, leukocyturia, slight blood urine and its its Cylindruria etc..Late period can cause detection of glomeruli filtration function to decline, and renal insufficiency occur.

（2）Uric acid lithangiuria urine uric acid concentration increases in hypersaturated state, is deposited in urinary system and forms knot Stone.Incidence in patient with gout is more than 20%, thereby increases and it is possible to come across gouty arthritis occur before.Calculus smaller is in It is gritty with urine ejection, can be asymptomatic；The greater can block urinary tract, cause renal colic, blood urine, dysuria, urinary infection, Pyclectasis and ponding etc..

（3）Acute uric acid nephropathy blood and its horizontal hurried rise of its urine uric acid, it is small that a large amount of uric acid crystals are deposited on kidney Pipe, concetrated pipe etc., cause acute urinary obstruction.Clinical manifestation is oliguresis, anuria, acute renal failure；It is visible big in urine Measure uric acid crystal.Mostly by malignant tumour and its its chemicotherapy（That is tumor lysis syndrome）Cause etc. secondary reason.

So, a kind of Chinese medicine composition that can effectively treat gout how is just found, is that those skilled in the art urgently will It solves the problems, such as.

The content of the invention

With the continuous development of China's traditional Chinese medicine, in treatment gout, people gradually appreciate Chinese traditional treatment pain The advantages of wind, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment gout Present situation, it is extensive early to solve patient with gout the purpose of the invention is to provide a kind of new medicine composition for treating gout The problem of rehabilitation health.The drug is using common Chinese medicine as raw material, by selecting rational drug and mass parts ratio, can effectively be controlled Treat above-mentioned gout.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：It provides and a kind of treats the new of gout Chinese medicine composition and preparation method, which is characterized in that each component and mass parts of the Chinese medicine composition are than as follows：

150~350g of claws of a hawk maple, 100~160g of pueraria lobata, 150~300g of berba aristolochiae mollissimae, 50~160g of Radix Salviae Miltiorrhizae, 50~160g of Radix Angelicae Sinensis, It is 100~350g of caulis lonicerae, 30~120g of Rhizoma Et Radix Notopterygii, 150~550g of coix seed, 30~120g of Radix Angelicae Pubescentis, 100~160g of plantain seed, big 50~160g of blood rattan, 100~350g of yellow Stilbene, 150~300g of Caulis Spatholobi, 50~100g of radix cynanchi atrati, auxiliary material：Superfine silica gel powder, crystallite are fine Dimension element and starch are appropriate.

A kind of new medicine composition for treating gout and preparation method, which is characterized in that the Chinese medicine composition it is each A component and mass parts are than as follows：

180~310g of claws of a hawk maple, 115~140g of pueraria lobata, 180~260g of berba aristolochiae mollissimae, 58~140g of Radix Salviae Miltiorrhizae, 56~140g of Radix Angelicae Sinensis, It is 115~310g of caulis lonicerae, 36~105g of Rhizoma Et Radix Notopterygii, 180~480g of coix seed, 36~105g of Radix Angelicae Pubescentis, 116~140g of plantain seed, big 56~140g of blood rattan, 118~310g of yellow Stilbene, 180~260g of Caulis Spatholobi, 56~90g of radix cynanchi atrati, auxiliary material：Superfine silica gel powder, microcrystalline cellulose Element and starch are appropriate.

A kind of new medicine composition for treating gout and preparation method, which is characterized in that the Chinese medicine composition it is each A component and mass parts are than as follows：

Claws of a hawk maple 280g, pueraria lobata 120g, berba aristolochiae mollissimae 230g, Radix Salviae Miltiorrhizae 120g, Radix Angelicae Sinensis 120g, caulis lonicerae 280g, Rhizoma Et Radix Notopterygii 95g, Job's tears Benevolence 420g, Radix Angelicae Pubescentis 95g, plantain seed 120g, sargentodoxa cuneata 120g, yellow Stilbene 280g, Caulis Spatholobi 230g, radix cynanchi atrati 80g, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.

A kind of new medicine composition for treating gout and preparation method, which is characterized in that the described method includes following steps Suddenly it is prepared：

A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, it is ground into according to mass parts than altogether（30~50 mesh）Graininess bag It decocts；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 40min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. the mixing of secondary liquid is condensed into relative density is 1.08 clear cream, it is then dry, grind with it is after disinfection to reserve；

C, the method for 1. preparing Chinese medicine capsules according to tradition after smalls sieving ground in B, adds in suitable micro mist silicon Glue, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Its capsule it is sealed after total length be 23.3mm, medicinal powder Capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

A kind of new medicine composition for treating gout and preparation method, which is characterized in that the instructions of taking is：It will system The capsule medicine got ready to take 3 times a day, and once a dose in the morning, afternoon and evening, dosage 2.5g（5）/ time, warm water is sent after meal Clothes.（Quit smoking during medication, wine, raw green onion, raw garlic, pungent irritable food）.30 days as a treatment course, 3~7 courses for the treatment of of taking medicine, Clinical symptoms and sign disappear, and functional activity recovers normal, and disease obtains interim healing.

Each raw material Chinese medicine in prescription of the present invention has detailed in Chinese Pharmacopoeia, Chinese dictionary and its China's book on Chinese herbal medicine It records.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

Claws of a hawk maple, nature and flavor：Slight bitter is trembled with fear, and has the effect of cold dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, for treating arthralgia pain due to rheumatism, bruise damage Wound；

Pueraria lobata, nature and flavor：It is sweet in flavor, pungent, cool in nature, have expelling pathogenic factors from muscles and skin bring down a fever, promoting eruption, promote the production of body fluid to quench thirst, Shengyang Zhixie the effect of, for treating Exterior syndrome fever, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, the deficiency of Yin is quenched one's thirst, heat is purged heat dysentery, splenasthenic diarrhea；

Berba aristolochiae mollissimae, nature and flavor：It is acrid flavour, hardship, mild-natured, there is the effect of dispelling wind and removing obstruction in the meridians, analgesic, for treating arthralgia pain due to rheumatism, stomachache, testis Ball swelling and pain, injuries from falls as well；

Radix Salviae Miltiorrhizae, nature and flavor：It is bitter, be slightly cold, there is the effect of promoting blood circulation, cool blood to disappear carbuncle, nourishing blood and tranquilization, for treat irregular menstruation, The diseases such as trusted subordinate's pain, lumps in the chest and abdomen, beriberoid pyretic arthralgia, sore swell and ache curative, agitation are insomnia, palpitaition, insomnia；

Radix Angelicae Sinensis, nature and flavor：It is sweet in flavor, pungent, bitter, warm-natured, there is the effect of enriching blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, for treating The all cards of the deficiency of blood, irregular menstruation, Amenorrhea, dysmenorrhoea, Disorder lump in the abdomen knots gather, uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, red Weight, ulcer sores, injury from falling down after dysentery；

Caulis lonicerae, nature and flavor：It is sweet, cold, there is the effect of clearing heat and detoxicating, dispelling wind dredging collateral, for treat warm disease heating, toxic-heat and blood stasis, Carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain；

Rhizoma Et Radix Notopterygii, nature and flavor：Acrid, bitter, warm has the effect of relieving exterior syndrome and dispelling cold, dispelling wind and eliminating dampness, analgesic, for treating anemofrigid cold, headache Xiang Qiang, arthralgia pain due to rheumatism, aching pain in shoulder and back；

Coix seed, nature and flavor：It is sweet, light, be slightly cold, have dampness removing invigorating the spleen, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus the effect of, for treat oedema, Under tinea pedis, dribbling urination, damp-warm diseases, diarrhea band, the diseases such as arthralgia pain due to rheumatism, muscle arteries and veins contraction, lung carbuncle, acute appendicitis, flat wart；

Radix Angelicae Pubescentis, nature and flavor：Acrid flavour, hardship, slightly warm in nature have the effect of dispelling wind and eliminating dampness, arthritis analgesic, for treating wind-cold-dampness arthralgia, wanting It washes pain, few the moon volt wind headache, chill and holds the diseases such as wet headache under the arm；

Plantain seed, nature and flavor：It is sweet in flavor, cold in nature, there is the effect for the treatment of stranguria reducing fever and causing diuresis, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm, for treating Puckery pain of heat gonorrhea, oedema turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough；

Sargentodoxa cuneata, nature and flavor：Mild-natured, bitter, have clearing heat and detoxicating, promoting blood circulation by removing wind, analgesic the effect of, for treat abdominalgia with intestinal abscess, Closed dysmenorrhea, arthralgia pain due to rheumatism, tumbling and swelling；

Yellow Stilbene, nature and flavor：Sweet, tepor has the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, The diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；

Caulis Spatholobi, nature and flavor：It is bitter, micro-sweet, warm-natured, there is the effect of activating blood and relaxing tendons, nourishing blood for regulating menstruation, for treat it is numb in every limb, Quadriplegia, arthralgia pain due to rheumatism, women have through diseases such as uncomfortable, dysmenorrhoea, amenorrhoeas；

Radix cynanchi atrati, nature and flavor：It is bitter, salty, cold, there is the effect of clearing heat and cooling blood, inducing diuresis for treating strangurtia, detoxification sore treatment, for treating warm evil wound battalion Fever, fever due to yin deficiency, hectic fever due to yin labor heat, postpartum fever caused by blood deficiency, heat gonorrhea, blood strangury, swollen ulcer drug.

Drug of the present invention is the principle based on Chinese traditional treatment gout, is recognized from the pathomechanism according to gout and pharmacological action For：With regard to gout, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, there is treatment effect well to above-mentioned disease Fruit.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned gout, the drug prepared using the formula Good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific implementation of the present invention Mode is described in further detail：

Embodiment 1：

A kind of new medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition Than as follows：

Claws of a hawk maple 280g, pueraria lobata 120g, berba aristolochiae mollissimae 230g, Radix Salviae Miltiorrhizae 120g, Radix Angelicae Sinensis 120g, caulis lonicerae 280g, Rhizoma Et Radix Notopterygii 95g, Job's tears Benevolence 420g, Radix Angelicae Pubescentis 95g, plantain seed 120g, sargentodoxa cuneata 120g, yellow Stilbene 280g, Caulis Spatholobi 230g, radix cynanchi atrati 80g, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.

Embodiment 2：

A kind of new medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition Than as follows：

Claws of a hawk maple 310g, pueraria lobata 140g, berba aristolochiae mollissimae 260g, Radix Salviae Miltiorrhizae 140g, Radix Angelicae Sinensis 140g, caulis lonicerae 310g, Rhizoma Et Radix Notopterygii 105g, Job's tears Benevolence 480g, Radix Angelicae Pubescentis 105g, plantain seed 140g, sargentodoxa cuneata 140g, yellow Stilbene 310g, Caulis Spatholobi 260g, radix cynanchi atrati 90g, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.

Embodiment 3：

A kind of new medicine composition for treating gout, which is characterized in that each component and mass parts of the Chinese medicine composition Than as follows：

Claws of a hawk maple 350g, pueraria lobata 160g, berba aristolochiae mollissimae 300g, Radix Salviae Miltiorrhizae 160g, Radix Angelicae Sinensis 160g, caulis lonicerae 350g, Rhizoma Et Radix Notopterygii 120g, Job's tears Benevolence 550g, Radix Angelicae Pubescentis 120g, plantain seed 160g, sargentodoxa cuneata 160g, yellow Stilbene 350g, Caulis Spatholobi 300g, radix cynanchi atrati 100g, auxiliary material：Micro mist Silica gel, microcrystalline cellulose and appropriate starch.

Model case：

Through clinical conditions patient with gout totally 1428, the age is 911 of 55 years old or more, and only 517 are less than 55 years old. Clinical symptom and sign disappears in 1428 patients, and functional activity recovers normally have 975, effective 382, and invalid 71 Example.Total effective rate is up to 95%.

Claims (3)

1. a kind of new medicine composition for treating gout, which is characterized in that each component and quality of the Chinese medicine composition Part is than as follows：

150~350g of claws of a hawk maple, 100~160g of pueraria lobata, 150~300g of berba aristolochiae mollissimae, 50~160g of Radix Salviae Miltiorrhizae, 50~160g of Radix Angelicae Sinensis, It is 100~350g of caulis lonicerae, 30~120g of Rhizoma Et Radix Notopterygii, 150~550g of coix seed, 30~120g of Radix Angelicae Pubescentis, 100~160g of plantain seed, big 50~160g of blood rattan, 100~350g of yellow Stilbene, 150~300g of Caulis Spatholobi, 50~100g of radix cynanchi atrati, auxiliary material：Superfine silica gel powder, crystallite are fine Dimension element and starch are appropriate.

2. the new medicine composition for the treatment of gout according to claim 1, which is characterized in that the Chinese medicine composition Each component and mass parts are than as follows：

180~310g of claws of a hawk maple, 115~140g of pueraria lobata, 180~260g of berba aristolochiae mollissimae, 58~140g of Radix Salviae Miltiorrhizae, 56~140g of Radix Angelicae Sinensis, It is 115~310g of caulis lonicerae, 36~105g of Rhizoma Et Radix Notopterygii, 180~480g of coix seed, 36~105g of Radix Angelicae Pubescentis, 116~140g of plantain seed, big 56~140g of blood rattan, 118~310g of yellow Stilbene, 180~260g of Caulis Spatholobi, 56~90g of radix cynanchi atrati, auxiliary material：Superfine silica gel powder, microcrystalline cellulose Element and starch are appropriate.

3. the new medicine composition of the treatment gout according to claim 1 to 2, which is characterized in that the Chinese traditional medicine composition The each component and mass parts of object are than as follows：

Claws of a hawk maple 280g, pueraria lobata 120g, berba aristolochiae mollissimae 230g, Radix Salviae Miltiorrhizae 120g, Radix Angelicae Sinensis 120g, caulis lonicerae 280g, Rhizoma Et Radix Notopterygii 95g, Job's tears Benevolence 420g, Radix Angelicae Pubescentis 95g, plantain seed 120g, sargentodoxa cuneata 120g, yellow Stilbene 280g, Caulis Spatholobi 230g, radix cynanchi atrati 80g, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.