CN108114209A - A kind of capsule medicine and preparation method for being used to treat gout - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of capsule medicine for being used to treat gout be provided according to the understanding mechanism of Chinese traditional treatment gout, each component and its mass parts ratio of the drug are as follows：30~100g of edible tulip, 150~300g of yellow Stilbene, 30~120g of Rhizoma Et Radix Notopterygii, 100~350g of radix rehmanniae recen, 150~300g of honeysuckle, 60~120g of the root of Chinese clematis, 60~120g of radix cyathulae, 150~300g of erythrina bark, 30~100g of the tuber of pinellia, 60~100g of pawpaw, 30~100g of Radix Notoginseng, 100~160g of plantain seed, 150~260g of garlic, 250~560g of smilax, 30~150g of Radix Glycyrrhizae；Drug provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method for being used to treat gout

Technical field

The invention belongs to field of traditional Chinese, and in particular to and it is a kind of for treating the capsule medicine of gout, particularly supply The capsule medicine and the field of preparation method that patient with gout uses.

Background technology

Doctor thinks：Gout is by monosodium urate salt（MSU）Crystal correlation arthropathy caused by deposition, with purine metabolism It is disorderly and（Or）Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic gout Stone disease mainly includes acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and urine Acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout often with Central obesity, hyperlipidemia, hypertension, The performances such as diabetes B and cardiovascular disease.

Clinical manifestation：Gout is more common in middle-aged male, and women only accounts for 5%, and mainly postmenopausal women, gout have year Lightization trend.The natural history of gout can be divided into the fourth phase, i.e., asymptomatic hyperuricemia phase, acute stage, intermittent phase, chronic phase [3].Clinical manifestation is as follows：

1. acute gouty arthritis

Without apparent sign or only tired, general malaise and joint sting etc. before most of patients breaking-out.Typical onset is often in the late into the night It is waken up with a start due to arthralgia, the aggravation of pain progressive, up to peak when 12 is small or so, sample is bitten in tearing sample, cut sample or stinging, it is difficult to It endures.Affected joints and surrounding tissue is red, swollen, hot, pain and function limitation.It is interior more than a couple of days or 2 weeks voluntarily to alleviate.First-episode Invade simple joint, part is above to be happened at Metatarsophalangeal joint, and in the course of disease afterwards, some patientss involve the position more.Its It is secondary to be involved less for joints, the joints such as shoulder, hip, backbone and temporo jaw such as instep, heel, ankle, knee, wrist and elbows, it can involve simultaneously multiple Joint shows as panarthritis.Some patientss can have the constitutional symptoms such as fever, shiver with cold, headache, palpitaition and nausea, can be with white thin Born of the same parents count rise, erythrocyte sedimentation rate (ESR) speeds and increases with c reactive protein.

2. interval stage of attack

Gout can voluntarily be alleviated after breaking-out last from days to several weeks, generally without apparent sequelae shape or leave local skin pigment Calm, furfur and scratchy etc., later into the asymptomatic intermittent phase, recurs, most of patients after lasting several months, several years or more than ten years It is recurred in 1 year, more more frequently, affected joints are more and more, and symptom duration is increasingly longer.Affected joints generally from lower limb to Upper limb develops from distal end Minor articulus to large joint, occurs referring to, the joint involvements such as wrist and elbow, small number of patients can influence shoulder, hip, Sacrum ilium, chest lock or joint of vertebral column, can also involve the positions such as periarticular synovial bursa, tendon and stndon sheath, symptom tends to not be true to type.It is a small number of Patient's Non-intermittent phase is showed in chornic arthritis after first attack.

3. the chronic gout stone lesion phase

Subcutaneous tophus and chronic gout stone arthritis are long-term significant hyperuricemias, and a large amount of monosodium urate salt crystals are sunk Product is in the result of subcutaneous, synovium of joint, cartilage, sclerotin and periarticular soft tissues.Subcutaneously the typical parts of tophus generation are Auricle is also common in the positions such as periarticular and olecranon, the heel string and kneecap synovial bursa of recurrent exerbation.Appearance is big subcutaneously to swell The small yellow-white neoplasm to differ, skin surface are belittled, and white powder or paste are discharged after ulceration, is not recovered for a long time.Subcutaneous pain Wind stone is often with chronic gout stone arthritis and depositing.The intra-articular tophus largely deposited can cause joint destruction of bone, joint Surrounding tissue fibrosis and secondary degenerative change etc..Clinical manifestation is to continue painful swelling of joints, tenderness, deformity and dysfunction. Chronic phase symptom is opposite to be mitigated, but can also have acute attack.

4. renal lesions

（1）Chronic urate nephropathy urate crystals are deposited on renal interstitial, cause chronic one interstitial nephritis of renal tubule.Clinical table Now decline for urine concentrating power, occur enuresis nocturna increase, low-gravity urine, small molecular protein urine, leukocyturia, slight blood urine and cast Urine etc..Late period can cause detection of glomeruli filtration function to decline, and renal insufficiency occur.

（2）Uric acid lithangiuria urine uric acid concentration increases in hypersaturated state, is deposited in urinary system and forms knot Stone.Incidence in patient with gout is more than 20%, thereby increases and it is possible to come across gouty arthritis occur before.Calculus smaller is in It is gritty with urine ejection, can be asymptomatic；The greater can block urinary tract, cause renal colic, blood urine, dysuria, urinary infection, Pyclectasis and ponding etc..

（3）Acute uric acid nephropathy blood and the horizontal hurried rise of urine uric acid, a large amount of uric acid crystals are deposited on renal tubule, collection Pipe etc. is closed, causes acute urinary obstruction.Clinical manifestation is oliguresis, anuria, acute renal failure；Visible a large amount of uric acid in urine Crystal.Mostly by malignant tumour and chemicotherapy（That is tumor lysis syndrome）Cause etc. secondary reason.

So, a kind of Chinese medicine composition that can effectively treat gout how is just found, is that those skilled in the art urgently will It solves the problems, such as.

The content of the invention

With the continuous development of China's traditional Chinese medicine, in treatment gout, people gradually appreciate Chinese traditional treatment pain The advantages of wind, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment gout Present situation, it is extensive early to solve patient with gout the purpose of the invention is to provide a kind of for treating the capsule medicine of gout The problem of rehabilitation health.The drug is using common Chinese medicine as raw material, by selecting rational drug and mass parts ratio, can effectively be controlled Treat above-mentioned gout.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：It provides a kind of for treating gout Capsule medicine and preparation method, which is characterized in that each component and mass parts of the drug are than as follows：

30~100g of edible tulip, 150~300g of yellow Stilbene, 30~120g of Rhizoma Et Radix Notopterygii, 100~350g of radix rehmanniae recen, honeysuckle 150~ 300g, 60~120g of the root of Chinese clematis, 60~120g of radix cyathulae, 150~300g of erythrina bark, 30~100g of the tuber of pinellia, 60~100g of pawpaw, 30~100g of Radix Notoginseng, 100~160g of plantain seed, 150~260g of garlic, 250~560g of smilax, 30~150g of Radix Glycyrrhizae, auxiliary material： Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat gout, which is characterized in that each component of the drug And mass parts are than as follows：

36~90g of edible tulip, yellow 180~260g of Stilbene, 36~105g of Rhizoma Et Radix Notopterygii, 115~310g of radix rehmanniae recen, 180~260g of honeysuckle, 70~105g of the root of Chinese clematis, 70~105g of radix cyathulae, 180~260g of erythrina bark, 36~90g of the tuber of pinellia, 70~90g of pawpaw, Radix Notoginseng 36 ~90g, 116~140g of plantain seed, 180~230g of garlic, 280~480g of smilax, 36~130g of Radix Glycyrrhizae, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat gout, which is characterized in that each component of the drug And mass parts are than as follows：

Edible tulip 80g, yellow Stilbene 230g, Rhizoma Et Radix Notopterygii 95g, radix rehmanniae recen 280g, honeysuckle 230g, root of Chinese clematis 95g, radix cyathulae 95g, pittosporum tobira Skin 230g, tuber of pinellia 80g, pawpaw 80g, Radix Notoginseng 80g, plantain seed 120g, garlic 200g, smilax 420g, Radix Glycyrrhizae 118g, auxiliary material： Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat gout, which is characterized in that the described method includes following steps Suddenly it is prepared：

A, except Radix Notoginseng（It grinds）It is for use outer, after above-mentioned other raw material Chinese medicines are picked impurity and dust, according to mass parts than common powder It is broken into（30~50 mesh）Graininess is decocted a drug wrapped；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 50min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. the mixing of secondary liquid is condensed into relative density is 1.08 clear cream, it is then dry, grind with it is after disinfection to reserve；

C, the method for 1. preparing Chinese medicine capsules according to tradition after smalls sieving ground in A and B, adds in suitable micro- Powder silica gel, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Total length is 23.3mm after its capsule is sealed, Medicinal powder capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

It is a kind of for treating the capsule medicine and preparation method of gout, which is characterized in that the instructions of taking is：It will system The capsule medicine got ready is three times a day to take, and once a dose in the morning, afternoon and evening, dosage 2.4g（6）/ time, warm water is sent after meal Clothes.（Quit smoking during medication, wine, raw green onion, raw garlic, pungent irritable food）.28 days as a treatment course treat 3~7 courses for the treatment of Afterwards, clinical symptoms and sign disappear, and functional activity recovers normal completely.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine It carries.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

Edible tulip, nature and flavor：It is sweet, micro-pungent, cool, there is the effect of clearing heat and detoxicating, reducing phlegm and resolving masses, for treating carbuncle swells serious case of furuncle, scrofula Subcutaneous nodule, snakebite and bugbite, lame lump in the abdomen lump in the abdomen；

Yellow Stilbene, nature and flavor：Sweet, tepor has the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, The diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；

Rhizoma Et Radix Notopterygii, nature and flavor：Acrid, bitter, warm has the effect of relieving exterior syndrome and dispelling cold, dispelling wind and eliminating dampness, analgesic, for treating anemofrigid cold, headache Xiang Qiang, arthralgia pain due to rheumatism, aching pain in shoulder and back；

Radix rehmanniae recen, nature and flavor：It is sweet in flavor, bitter, cold in nature, there is the effect of heat-clearing, cool blood, enter ying blood, high fever for treating warm heat disease heat Coma, dry tongue are deep red；

Honeysuckle, nature and flavor：It is sweet, cold, have it is clearing heat and detoxicating the effect of, for treat warm disease heating, toxic-heat and blood stasis, carbuncle swells furunculosis, Larynx numbness and multi-infection disease；

The root of Chinese clematis, nature and flavor：It is acrid flavour, salty, warm-natured, play an important role of there is the effect of wind-damp dispelling, degrading the channel, for treating rheumatism numbness Bitterly, the diseases such as extremity numbness, muscle arteries and veins contraction, joint stuffiness；

Radix cyathulae, nature and flavor：It is sweet, slight bitter, mild-natured, there is the effect of promoting blood circulation, expelling wind and removing dampness, for treating blood stasis, difficulty Production, placenta retension, postpartum blood stasis abdominal pain, heat gonorrhea, urolithiasis, dysmenorrhoea, rheumatism lumbocrural pain；

Erythrina bark, nature and flavor：It is bitter, flat, there is the effect of wind-damp dispelling, channels sootheing and network vessel quickening, for treating rheumatic numbness, waist-leg muscles and bones pain Bitterly, various stubborn dermatitis are controlled in traumatic injury, external application；

The tuber of pinellia, nature and flavor：It is acrid flavour, warm-natured, there is the effect of eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for treating for damp phlegm Cold phlegm, cough and phlegm, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus, controlling outward carbuncle swells phlegm Core；

Pawpaw, nature and flavor：Acid, temperature, have the effect of soothing the liver, relaxing muscles and tendons and spleen, dampness elimination, for treating arthritis with fixed pain caused by dampness, tinea pedis, cholera, spitting It rushes down, the diseases such as abdominal pain, convulsion；

Radix Notoginseng, nature and flavor：Sweet, slight bitter, temperature, have dissipate stasis of blood hemostasis, detumescence ding-tong the effect of, for treat spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, It has blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling；

Plantain seed, nature and flavor：It is sweet in flavor, cold in nature, there is the effect for the treatment of stranguria reducing fever and causing diuresis, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm, for treating Puckery pain of heat gonorrhea, oedema turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough；

Garlic, nature and flavor：It is pungent, warm, there is the effect of stomach invigorating, stop dysentery, cough-relieving, sterilization, expelling parasite, it is popular sexy for Prevention Emit, meningococal meningitis, control pulmonary tuberculosis, pertussis, loss of appetite, indigestion, bacillary dysentery, amoebic dysentery, Trichomonas vaginalis, acute appendicitis are controlled in enteritis, enterobiasis, hookworm disease, external application；

Smilax, nature and flavor：It is sweet light, flat, there is the effect of removing toxic substances, dehumidifying, sharp joint, for treating syphilis, stranguria with turbid discharge, muscles and bones contraction Bitterly, the diseases such as tinea pedis, furunculosis, carbuncle swells, scrofula；

Radix Glycyrrhizae, nature and flavor：It is sweet, flat, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, use It swells in treatment burnout deficiency of food, the thin face Huang of flesh, palpitation, abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, throat Bitterly, the diseases such as ulcerative carbuncle swelling and pain, infant fetal toxin and drug, food poisoning.

Drug of the present invention is the principle based on Chinese traditional treatment gout, is recognized from the pathomechanism according to gout and pharmacological action For：With regard to gout, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, there is treatment effect well to above-mentioned disease Fruit.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned gout, the drug prepared using the formula Good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific implementation of the present invention Mode is described in further detail：

Embodiment 1：

A kind of capsule medicine for being used to treat gout, which is characterized in that each component and mass parts ratio of the drug are as follows It is shown：

Edible tulip 80g, yellow Stilbene 230g, Rhizoma Et Radix Notopterygii 95g, radix rehmanniae recen 280g, honeysuckle 230g, root of Chinese clematis 95g, radix cyathulae 95g, pittosporum tobira Skin 230g, tuber of pinellia 80g, pawpaw 80g, Radix Notoginseng 80g, plantain seed 120g, garlic 200g, smilax 420g, Radix Glycyrrhizae 118g, auxiliary material： Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

Embodiment 2：

A kind of capsule medicine for being used to treat gout, which is characterized in that each component and mass parts ratio of the drug are as follows It is shown：

Edible tulip 90g, yellow Stilbene 260g, Rhizoma Et Radix Notopterygii 105g, radix rehmanniae recen 310g, honeysuckle 260g, root of Chinese clematis 105g, radix cyathulae 105g, Erythrina bark 260g, tuber of pinellia 90g, pawpaw 90g, Radix Notoginseng 90g, plantain seed 140g, garlic 230g, smilax 480g, Radix Glycyrrhizae 130g, it is auxiliary Material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

Embodiment 3：

A kind of capsule medicine for being used to treat gout, which is characterized in that each component and mass parts ratio of the drug are as follows It is shown：

Edible tulip 100g, yellow Stilbene 300g, Rhizoma Et Radix Notopterygii 120g, radix rehmanniae recen 350g, honeysuckle 300g, root of Chinese clematis 120g, radix cyathulae 120g, Erythrina bark 300g, tuber of pinellia 100g, pawpaw 100g, Radix Notoginseng 100g, plantain seed 160g, garlic 260g, smilax 560g, Radix Glycyrrhizae 150g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

Model case：

Through clinical conditions patient with gout totally 1320, the age is 810 of 67 years old or more, and only 510 are less than 67 years old. Clinical symptom and sign disappears in 1320 patients, and functional activity recovers normally have 925, effective 303, and invalid 92 Example.Total effective rate is up to 93%.

Claims (3)

1. a kind of capsule medicine for being used to treat gout, which is characterized in that each component and its mass parts ratio of the drug It is as follows：

30~100g of edible tulip, 150~300g of yellow Stilbene, 30~120g of Rhizoma Et Radix Notopterygii, 100~350g of radix rehmanniae recen, honeysuckle 150~ 300g, 60~120g of the root of Chinese clematis, 60~120g of radix cyathulae, 150~300g of erythrina bark, 30~100g of the tuber of pinellia, 60~100g of pawpaw, 30~100g of Radix Notoginseng, 100~160g of plantain seed, 150~260g of garlic, 250~560g of smilax, 30~150g of Radix Glycyrrhizae, auxiliary material： Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

2. the capsule medicine according to claim 1 for being used to treat gout, which is characterized in that each group of the drug Divide and its mass parts are than as follows：

36~90g of edible tulip, yellow 180~260g of Stilbene, 36~105g of Rhizoma Et Radix Notopterygii, 115~310g of radix rehmanniae recen, 180~260g of honeysuckle, 70~105g of the root of Chinese clematis, 70~105g of radix cyathulae, 180~260g of erythrina bark, 36~90g of the tuber of pinellia, 70~90g of pawpaw, Radix Notoginseng 36 ~90g, 116~140g of plantain seed, 180~230g of garlic, 280~480g of smilax, 36~130g of Radix Glycyrrhizae, auxiliary material：Micro mist silicon Glue, microcrystalline cellulose and appropriate starch.

3. according to claim 1 to 2 for treating the capsule medicine of gout, which is characterized in that the drug it is each A component and its mass parts are than as follows：

Edible tulip 80g, yellow Stilbene 230g, Rhizoma Et Radix Notopterygii 95g, radix rehmanniae recen 280g, honeysuckle 230g, root of Chinese clematis 95g, radix cyathulae 95g, pittosporum tobira Skin 230g, tuber of pinellia 80g, pawpaw 80g, Radix Notoginseng 80g, plantain seed 120g, garlic 200g, smilax 420g, Radix Glycyrrhizae 118g, auxiliary material： Superfine silica gel powder, microcrystalline cellulose and appropriate starch.