CN107753662A - A kind of capsule medicine for treating gout and preparation method thereof - Google Patents
A kind of capsule medicine for treating gout and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of capsule medicine for treating gout according to the understanding mechanism of Chinese traditional treatment gout, each component and its mass parts ratio of the medicine are as follows:50~160g of rhizoma atractylodis macrocephalae, 50~160g of root of bidentate achyranthes root, 90~360g of the Radix Astragali, 100~160g of Poria cocos, 15~70g of cassia twig, 60~100g of cortex acanthopanacis, 80~160g of the root of fangji, 150~360g of negundo chastetree root, 30~180g of gun additioner, 30~80g of caulis clematidis armandii, 80~160g of the root of kudzu vine, 90~160g of the root bark of Chinese wolf-berry, 30~70g of frankincense, 15~100g of ginseng, 100~260g of the fruit of Chinese wolfberry, 50~120g of safflower, medicine provided by the invention are a good Chinese prescriptions.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine for treating gout, particularly for gout
The field of the capsule medicine that patient uses and preparation method thereof.
Background technology
Motherland's medical science thinks:Gout is by monosodium urate salt(MSU)Crystal correlation arthropathy caused by deposition, with purine
Metabolic disorder and(Or)Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic
Tophus disease, mainly include acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy
With uric acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout is often with Central obesity, hyperlipidemia, height
Blood pressure, diabetes B and cardiovascular disease etc. show.
Clinical manifestation:
Gout is more common in middle-aged male, and women only accounts for 5%, mainly postmenopausal women, and gout has rejuvenation trend.Gout
Natural history can be divided into the fourth phase, i.e., asymptomatic hyperuricemia phase, acute stage, intermittent phase, chronic phase [3].Clinical manifestation is such as
Under:
A. acute gouty arthritis
Without obvious sign before most of patients breaking-out, or only tired, general malaise and joint sting etc..Typical onset is often in the late into the night
Waken up with a start because of arthralgia, the aggravation of pain progressive, reached peak at 12 hours or so, sample is bitten in tearing sample, cut sample or stinging, it is difficult to
Endure.Affected joints and surrounding tissue is red, swollen, hot, pain and function limitation.It is interior more than a couple of days or 2 weeks voluntarily to alleviate.First-episode
It is invade simple joint more, more than part occur in Metatarsophalangeal joint, the course of disease afterwards, some patientss involve the position.Its
It is secondary to be involved less for joints such as joint, shoulder, hip, backbone and temporo jaw such as instep, heel, ankle, knee, wrist and elbows, it can involve simultaneously multiple
Joint, show as panarthritis.Some patientss can have the constitutional symptoms such as heating, shiver with cold, headache, palpitaition and nausea, can be with white thin
Born of the same parents count rise, erythrocyte sedimentation rate (ESR) speeds and increased with c reactive protein.
B. interval stage of attack
Gout can voluntarily be alleviated after breaking-out last from days to several weeks, typically without obvious sequelae shape, or leave local skin pigment
Calm, furfur and scratchy etc., later into the asymptomatic intermittent phase, recurs, most of patients after lasting several months, several years or more than ten years
Recurred in 1 year, all the more more frequently, affected joints are more and more, and symptom duration is increasingly longer.Affected joints typically from lower limb to
Upper limbs, develop from distal end Minor articulus to large joint, occur referring to, the joint involvement such as wrist and elbow, small number of patients can have influence on shoulder, hip,
Sacrum ilium, chest lock or joint of vertebral column, can also involve the positions such as periarticular synovial bursa, tendon and stndon sheath, symptom tends to not be true to type.It is a small number of
Patient's Non-intermittent phase, showed in chornic arthritis after first attack.
C. the chronic gout stone lesion phase
Subcutaneous tophus and chronic gout stone arthritis are long-term significant hyperuricemias, and a large amount of monosodium urate salt crystals are sunk
Product is in the result of subcutaneous, synovium of joint, cartilage, sclerotin and periarticular soft tissues.Subcutaneously the typical parts of tophus generation are
Auricle, also it is common in the positions such as periarticular and olecranon, the heel string and kneecap synovial bursa of recurrent exerbation.Outward appearance is big subcutaneously to swell
The small yellow-white neoplasm to differ, skin surface are belittled, and white powder or pastel are discharged after ulceration, is not recovered for a long time.Subcutaneous pain
Wind stone is often with chronic gout stone arthritis and depositing.The intra-articular tophus largely deposited can cause joint destruction of bone, joint
Surrounding tissue fibrosis and secondary degenerative change etc..Clinical manifestation is to continue painful swelling of joints, tenderness, deformity and dysfunction.
Chronic phase symptom is relative to be relaxed, but can also have acute attack.
D. renal lesions
(1)Chronic urate nephropathy urate crystals are deposited on renal interstitial, cause the chronic interstitial nephritis of renal tubule one.Clinical table
Now decline for urine concentrating power, occur enuresis nocturna increase, low-gravity urine, small molecular protein urine, leukocyturia, slight blood urine and cast
Urine etc..Late period can cause detection of glomeruli filtration function to decline, and renal insufficiency occur.
(2)Uric acid lithangiuria urine uric acid concentration increases in hypersaturated state, is deposited in urinary system and forms knot
Stone.Incidence in patient with gout is more than 20%, thereby increases and it is possible to come across gouty arthritis occur before.Calculus smaller is in
It is gritty with urine ejection, can be asymptomatic;The greater can block urinary tract, cause renal colic, blood urine, dysuria, urinary infection,
Pyclectasis and ponding etc..
(3)The horizontal hurried rise of acute uric acid nephropathy blood and urine uric acid, a large amount of uric acid crystals are deposited on renal tubule, collection
Pipe etc. is closed, causes acute urinary obstruction.Clinical manifestation is oliguresis, anuria, acute renal failure;Visible a large amount of uric acid in urine
Crystal.More by malignant tumour and its chemicotherapy(That is tumor lysis syndrome)Cause etc. secondary reason.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment gout, people gradually appreciate Chinese traditional treatment pain
The advantages of wind, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment gout
Present situation, the purpose of the present invention are to be to provide a kind of capsule medicine for treating gout, recover strong early to solve patient with gout
The problem of health.The medicine is using common Chinese medicine as raw material, by selecting rational medicine and mass parts ratio, can effectively be treated
State gout.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is:A kind of capsule for treating gout is provided
Agent medicine and preparation method thereof, it is characterised in that each component and mass parts of the medicine are than as follows:
50~160g of rhizoma atractylodis macrocephalae, 50~160g of root of bidentate achyranthes root, 90~360g of the Radix Astragali, 100~160g of Poria cocos, 15~70g of cassia twig, slender acanthopanax
60~100g of skin, 80~160g of the root of fangji, 150~360g of negundo chastetree root, 30~180g of gun additioner, 30~80g of caulis clematidis armandii, the root of kudzu vine 80
~160g, 90~160g of the root bark of Chinese wolf-berry, 30~70g of frankincense, 15~100g of ginseng, 100~260g of the fruit of Chinese wolfberry, 50~120g of safflower,
Auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine for treating gout and preparation method thereof, it is characterised in that each component of the medicine and
Mass parts are than as follows:
58~140g of rhizoma atractylodis macrocephalae, 58~140g of root of bidentate achyranthes root, 100~320g of the Radix Astragali, 115~140g of Poria cocos, 20~60g of cassia twig, five
Add 70~90g of skin, 90~140g of the root of fangji, 180~320g of negundo chastetree root, 38~150g of gun additioner, 38~70g of caulis clematidis armandii, the root of kudzu vine 90
~140g, 100~140g of the root bark of Chinese wolf-berry, 38~60g of frankincense, 20~90g of ginseng, 115~230g of the fruit of Chinese wolfberry, 58~105g of safflower,
Auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine for treating gout and preparation method thereof, it is characterised in that each component of the medicine and
Mass parts are than as follows:
Rhizoma atractylodis macrocephalae 120g, root of bidentate achyranthes root 120g, Radix Astragali 260g, Poria cocos 120g, cassia twig 52g, cortex acanthopanacis 80g, root of fangji 120g, negundo chastetree root
260g, gun additioner 130g, caulis clematidis armandii 60g, root of kudzu vine 120g, root bark of Chinese wolf-berry 120g, frankincense 52g, ginseng 80g, fruit of Chinese wolfberry 200g, safflower
95g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine for treating gout and preparation method thereof, it is characterised in that methods described comprises the following steps
It is prepared:
A, after above-mentioned raw materials Chinese medicine being picked into impurity and dust, it is ground into according to mass parts than altogether(30~50 mesh)Graininess bag
Decoct;
B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 60min, then soaked medicine is put into marmite again,
The cold boiling water for adding 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when 18min is arrived in decoction, turns slow fire and boils
120min, leaching decoction;2. the cold boiling water for adding 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time
Boil, when 15min is arrived in decoction, turn slow fire and boil 110min, leaching decoction;3. decoction mixing twice is condensed into relative density is
1.08 clear cream, then dry, grind and sterilize after it is standby;
C, the method for 1. preparing Chinese medicine capsules according to tradition, after smalls sieving ground in " B ", appropriate micro mist is added
Silica gel, microcrystalline cellulose and starch are well mixed, and are then prepared into capsule(Total length is 23.3mm after its capsule is sealed, medicine
Powder capacity 0.4~0.5g/ grains), 2. then polish, sterilize, sealed packaging.
A kind of capsule medicine for treating gout and preparation method thereof, it is characterised in that the instructions of taking is:It will prepare
Good capsule medicine is twice a day to take, and once a dose sooner or later, dosage 3.5g(7)/ time, warm water delivery service.15 days
For a course for the treatment of, after 2~3 courses for the treatment of of taking medicine, serum uric acid level is reduced, and symptom is obviously controlled.
Each raw material Chinese medicine in prescription of the present invention has in detail in Chinese Pharmacopoeia, Chinese medicine voluminous dictionary and China's book on Chinese herbal medicine
Thin record.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component:
Rhizoma atractylodis macrocephalae, nature and flavor:It is bitter, sweet, warm, have strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of, for treating insufficiency of the spleen food
Less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability etc.;
Root of bidentate achyranthes root, nature and flavor:Nature and flavor:It is bitter, sweet, sour, flat, there is dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia, ensuring proper downward flow of the blood
The effect of, for treating powerless Amenorrhea, dysmenorrhoea, soreness of waist and knee joint, muscles and bones, stranguria, oedema, headache, dizziness, toothache, day sore, telling
The diseases such as blood, bleeding from five sense organs or subcutaneous tissue;
The Radix Astragali, nature and flavor:Sweet, tepor, there is the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy
Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back,
The diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes;
Poria cocos, nature and flavor:It is sweet, light, flat, have eliminating dampness and diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative the effect of, for treat difficult urination,
The diseases such as oedema turgor, phlegm and retained fluid cough are inverse, vomiting, spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness, seminal emission gonorrhoea;
Cassia twig, nature and flavor:It is pungent, sweet, warm-natured, there is the effect of expelling cold and relieving exterior syndrome, warming meridian, activating YANG and prormoting functioning of QI, for treating chill table
The diseases such as card, numbness and ache of cold dampness, peripheral coldness, closed dysmenorrhea, Disorder lumps in the abdomen caking, the obstruction of qi in the chest, palpitaition, phlegm and retained fluid, difficult urination;
Cortex acanthopanacis, nature and flavor:It is acrid flavour, hardship, micro-sweet, warm-natured, there is the effect of wind-damp dispelling, filling liver kidney, strengthening the bones and muscles, promoting blood circulation arteries and veins, be used for
Treat wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, the retardation of walking of decimal a little, physically weak frail, traumatic injury, fracture, oedema, tinea pedis,
The illnesss such as uncontrolled urination;
The root of fangji, nature and flavor:It is bitter, cold, there is the effect of inducing diuresis for removing edema, wind-expelling pain-stopping, for treating oedema tinea pedis, difficult urination, wet
The diseases such as rash sore, arthralgia pain due to rheumatism, hypertension;
Negundo chastetree root, nature and flavor:Pungent, slight bitter, temperature, there is the effect of inducing diaphoresis, cough-relieving, dispelling wind and eliminating dampness, regulating qi-flowing for relieving pain, feel for treating
Emit, chronic bronchitis, arthralgia pain due to rheumatism, stomachache, eruptive disease, the disease such as stomachache;
Gun additioner, nature and flavor:Xin Gan, heat, it is poisonous, there is recuperating depleted yang, mends fire supporing yang, the effect of eliminating cold to stop pain, for treating the moon
Faint inverse, cold weak pulse of limb, trusted subordinate's crymodynia, cold dysentery, tinea pedis oedema, wind-cold-dampness arthralgia, Gong Leng, the cold of insufficiency type of Sheng Keyang, loss of YANG due to profuse perspiration, vomiting and diarrhoea is told
Rush down, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, the disease of cloudy subcutaneous ulcer sore and all chronic diseaseses;
Caulis clematidis armandii, nature and flavor:It is lightly seasoned, slight bitter, cold in nature, there is reducing fever and causing diuresis, stimulate the menstrual flow the effect of lower newborn, for treat the damp and hot retention of urine,
Oedema, stranguria, the aphthae of flaring up of heart fire, damp and hot numbness pain, articular instability, married woman's amenorrhoea, alactation;
The root of kudzu vine, nature and flavor:It is sweet, pungent, flat, have expelling pathogenic factors from muscles and skin bring down a fever, deliver examine, promote the production of body fluid to quench thirst, Shengyang Zhixie the effect of, for controlling
Treat fever caused by exogenous pathogens, rigidity of nape and headache, measles and go out that not smooth, warm disease is thirsty, diabete, diarrhea, dysentery, hypertension, coronary heart disease from the beginning of, rash
Deng disease;
The root bark of Chinese wolf-berry, nature and flavor:It is sweet, cold, there is the effect of heat-clearing, cool blood, for treating pulmonary tuberculosis hectic fever night sweat, lung heat cough and asthma, phlegm
Middle band blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, diabetes, high blood pressure etc.;
Frankincense, nature and flavor:Acrid, bitter, warm, there is the effect of blood-activating and qi-promoting analgesic, detumescence and promoting granulation, for treating chest impediment and cardialgia, gastral cavilty
Pain, dysmenorrhoea Amenorrhea, postpartum stasis, abdominal mass stomachache, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore;
Ginseng, nature and flavor:Sweet, slight bitter, temperature, have invigorating qi for relieving desertion, tonifying lung benefit spleen, promote the production of body fluid, calm the nerves, intelligence development the effect of, for treating
Tonifying Qi emergency treatment of collapse, Yixinfumai, calm the nerves, promote the production of body fluid, tonifying lung, the function such as invigorating the spleen, for treatment angiocardiopathy, stomach and liver diseases,
Diabetes, different types of nervous breakdown, various mental diseases, impotence and some cancers etc. have good therapeutic effect, are also a kind of
Strengthening by means of tonics medicine;
The fruit of Chinese wolfberry, nature and flavor:It is sweet, mild-natured, have nourishing the liver, nourshing kidney, moistening lung the effect of, for treat caused by liver and kidney deficiency, have a dizzy spell,
Visual one is clear, soreness and weakness of waist and knees, the expensive essence of impotence, cough due to consumptive disease, quenches one's thirst and draws drink;
Safflower, nature and flavor:It is acrid flavour, warm-natured, there is the effect of promoting blood circulation can be through, stasis-dispelling and pain-killing, for treating Amenorrhea, dysmenorrhoea, the postpartum stasis of blood
The diseases such as resistance stomachache, born of the same parents' numbness pained a lump in the abdomen causing distension and pain, traumatic injury, arthralgia, middle windage yaw are completed, macula.
Medicine of the present invention is the principle based on Chinese traditional treatment gout, is recognized from the pathomechanism according to gout and pharmacological action
For:Gout one is demonstrate,proved, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has good effect to above-mentioned disease
Fruit.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned gout, the medicine prepared using the formula
Good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific implementation of the present invention
Mode is described in further detail:
Embodiment 1:
A kind of capsule medicine for treating gout, it is characterised in that each component and mass parts of the medicine are than as follows:
Rhizoma atractylodis macrocephalae 120g, root of bidentate achyranthes root 120g, Radix Astragali 260g, Poria cocos 120g, cassia twig 52g, cortex acanthopanacis 80g, root of fangji 120g, negundo chastetree root
260g, gun additioner 130g, caulis clematidis armandii 60g, root of kudzu vine 120g, root bark of Chinese wolf-berry 120g, frankincense 52g, ginseng 80g, fruit of Chinese wolfberry 200g, safflower
95g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 2:
A kind of capsule medicine for treating gout, it is characterised in that each component and mass parts of the medicine are than as follows:
Rhizoma atractylodis macrocephalae 140g, root of bidentate achyranthes root 140g, Radix Astragali 320g, Poria cocos 140g, cassia twig 60g, cortex acanthopanacis 90g, root of fangji 140g, negundo chastetree root
It is 320g, gun additioner 150g, caulis clematidis armandii 70g, root of kudzu vine 140g, root bark of Chinese wolf-berry 140g, frankincense 60g, ginseng 90g, fruit of Chinese wolfberry 230g, red
Flower 105g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 3:
A kind of capsule medicine for treating gout, it is characterised in that each component and mass parts of the medicine are than as follows:
Rhizoma atractylodis macrocephalae 160g, root of bidentate achyranthes root 160g, Radix Astragali 360g, Poria cocos 160g, cassia twig 70g, cortex acanthopanacis 100g, root of fangji 160g, five-leaved chaste tree
Root 360g, gun additioner 180g, caulis clematidis armandii 80g, root of kudzu vine 160g, root bark of Chinese wolf-berry 160g, frankincense 70g, ginseng 100g, fruit of Chinese wolfberry 260g,
Safflower 120g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Model case
Through clinical conditions patient with gout totally 1390, the age is 815 of more than 59 years old, and only 575 are less than 59 years old.
Serum uric acid level reduces by 790, effective 489, invalid 111 be obviously controlled with symptom in 1390 patients.
Total effective rate is up to 92%.
Claims (3)
1. a kind of capsule medicine for treating gout, it is characterised in that each component and its mass parts ratio of the medicine are as follows
It is shown:
50~160g of rhizoma atractylodis macrocephalae, 50~160g of root of bidentate achyranthes root, 90~360g of the Radix Astragali, 100~160g of Poria cocos, 15~70g of cassia twig, slender acanthopanax
60~100g of skin, 80~160g of the root of fangji, 150~360g of negundo chastetree root, 30~180g of gun additioner, 30~80g of caulis clematidis armandii, the root of kudzu vine 80
~160g, 90~160g of the root bark of Chinese wolf-berry, 30~70g of frankincense, 15~100g of ginseng, 100~260g of the fruit of Chinese wolfberry, 50~120g of safflower,
Auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
2. it is according to claim 1 treatment gout capsule medicine, it is characterised in that each component of the medicine and
Its mass parts is than as follows:
58~140g of rhizoma atractylodis macrocephalae, 58~140g of root of bidentate achyranthes root, 100~320g of the Radix Astragali, 115~140g of Poria cocos, 20~60g of cassia twig, five
Add 70~90g of skin, 90~140g of the root of fangji, 180~320g of negundo chastetree root, 38~150g of gun additioner, 38~70g of caulis clematidis armandii, the root of kudzu vine 90
~140g, 100~140g of the root bark of Chinese wolf-berry, 38~60g of frankincense, 20~90g of ginseng, 115~230g of the fruit of Chinese wolfberry, 58~105g of safflower,
Auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
3. the capsule medicine of the treatment gout according to claim 1 to 2, it is characterised in that each group of the medicine
Divide and its mass parts are than as follows:
Rhizoma atractylodis macrocephalae 120g, root of bidentate achyranthes root 120g, Radix Astragali 260g, Poria cocos 120g, cassia twig 52g, cortex acanthopanacis 80g, root of fangji 120g, negundo chastetree root
260g, gun additioner 130g, caulis clematidis armandii 60g, root of kudzu vine 120g, root bark of Chinese wolf-berry 120g, frankincense 52g, ginseng 80g, fruit of Chinese wolfberry 200g, safflower
95g, auxiliary material:Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
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Publication Number | Publication Date |
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2017
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