CN108101887A - 哌啶-2,6-二酮衍生物及其在治疗克罗恩氏病中的用途 - Google Patents
哌啶-2,6-二酮衍生物及其在治疗克罗恩氏病中的用途 Download PDFInfo
- Publication number
- CN108101887A CN108101887A CN201711185728.6A CN201711185728A CN108101887A CN 108101887 A CN108101887 A CN 108101887A CN 201711185728 A CN201711185728 A CN 201711185728A CN 108101887 A CN108101887 A CN 108101887A
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- CN
- China
- Prior art keywords
- dione
- pharmaceutically acceptable
- isoindoline
- acceptable salts
- dioxopiperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
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| CN201711184758.5A Pending CN108101886A (zh) | 2016-11-24 | 2017-11-23 | 哌啶-2,6-二酮衍生物及其在治疗溃疡性结肠炎中的用途 |
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| CA (2) | CA3045703C (https=) |
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| AU2017366515B2 (en) | 2016-11-24 | 2021-01-21 | Ganzhou Hemay Pharmaceutical, Co., Ltd | Piperidine-2,6-diketone derivative and treatment for Crohn's disease |
| CN108727319A (zh) * | 2018-09-05 | 2018-11-02 | 常州大学 | 一种3-硝基邻苯二甲酸酐的制备方法 |
| CN109293631B (zh) * | 2018-11-30 | 2020-05-08 | 常州制药厂有限公司 | 3-氨基-n-(2，6-二氧代-3-哌啶基)-邻苯二甲酰亚胺化合物的制备方法 |
| GB202002926D0 (en) * | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
| CN111320604B (zh) * | 2020-04-22 | 2021-02-09 | 牡丹江医学院 | 一种治疗小儿口腔黏膜疾病的化合物、制备方法及其用途 |
| CN118370746A (zh) * | 2024-04-25 | 2024-07-23 | 江苏省中医院 | 马尿酸在制备溃疡性结肠炎治疗药物中的应用 |
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| WO2002070480A1 (es) * | 2001-03-01 | 2002-09-12 | Fundacion Universitaria San Pablo Ceu | Derivados de glutarimida como agentes terapeuticos |
| WO2005028436A2 (en) * | 2003-09-17 | 2005-03-31 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
| CN1844118A (zh) * | 2005-04-07 | 2006-10-11 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的哌啶－2，6－二酮衍生物 |
| CN1961876A (zh) * | 2005-11-08 | 2007-05-16 | 北京恩华医药研究院 | 邻苯二甲酰亚胺衍生物在制备抗新血管生成的药物中的用途 |
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| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| CN100488959C (zh) | 2003-03-27 | 2009-05-20 | 天津和美生物技术有限公司 | 水溶性的酞胺哌啶酮衍生物 |
| JP2008528514A (ja) * | 2005-01-25 | 2008-07-31 | セルジーン・コーポレーション | ４−アミノ−２−（３−メチル−２，６−ジオキソピペリジン−３−イル）−イソインドール−１，３−ジオンを使用する方法及び組成物 |
| ES2664872T3 (es) | 2010-06-18 | 2018-04-23 | Taiho Pharmaceutical Co., Ltd | Moduladores PRPK-TPRKB y sus usos |
| CN105246480A (zh) | 2013-04-02 | 2016-01-13 | 细胞基因公司 | 使用4-氨基-2-(2,6-二氧代-哌啶-3-基)-异吲哚啉-1,3-二酮治疗和控制中枢神经系统癌症的方法和组合物 |
| AU2017366515B2 (en) | 2016-11-24 | 2021-01-21 | Ganzhou Hemay Pharmaceutical, Co., Ltd | Piperidine-2,6-diketone derivative and treatment for Crohn's disease |
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- 2017-11-23 AU AU2017366515A patent/AU2017366515B2/en active Active
- 2017-11-23 US US16/464,224 patent/US11485724B2/en active Active
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- 2017-11-23 US US16/464,228 patent/US20220372013A2/en active Pending
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2022
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| WO2002070480A1 (es) * | 2001-03-01 | 2002-09-12 | Fundacion Universitaria San Pablo Ceu | Derivados de glutarimida como agentes terapeuticos |
| WO2005028436A2 (en) * | 2003-09-17 | 2005-03-31 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
| CN1867331A (zh) * | 2003-09-17 | 2006-11-22 | 美国政府健康及人类服务部 | 作为TNF－α调节剂的沙利度胺类似物 |
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| CN1961876A (zh) * | 2005-11-08 | 2007-05-16 | 北京恩华医药研究院 | 邻苯二甲酰亚胺衍生物在制备抗新血管生成的药物中的用途 |
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| US12331030B2 (en) | 2025-06-17 |
| JP2020500205A (ja) | 2020-01-09 |
| US20220306600A1 (en) | 2022-09-29 |
| CA3049161C (en) | 2023-03-07 |
| US20240132466A1 (en) | 2024-04-25 |
| US11485724B2 (en) | 2022-11-01 |
| CA3045703A1 (en) | 2018-05-31 |
| CA3045703C (en) | 2021-11-02 |
| JP7143296B2 (ja) | 2022-09-28 |
| WO2018095377A1 (zh) | 2018-05-31 |
| AU2017366515A1 (en) | 2019-06-13 |
| US20190389835A1 (en) | 2019-12-26 |
| EP3546449A4 (en) | 2020-06-10 |
| AU2017366515B2 (en) | 2021-01-21 |
| CA3049161A1 (en) | 2018-05-31 |
| JP7143295B2 (ja) | 2022-09-28 |
| EP3546450A1 (en) | 2019-10-02 |
| US20220372013A2 (en) | 2022-11-24 |
| AU2017366514B2 (en) | 2021-01-21 |
| WO2018095378A1 (zh) | 2018-05-31 |
| US20190352277A1 (en) | 2019-11-21 |
| JP2020500204A (ja) | 2020-01-09 |
| CN108101886A (zh) | 2018-06-01 |
| AU2017366514A1 (en) | 2019-06-13 |
| EP3546450A4 (en) | 2020-06-10 |
| US11873287B2 (en) | 2024-01-16 |
| EP3546449A1 (en) | 2019-10-02 |
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Address after: Door 2, Building 12, Huiying Industrial Park, No. 86 Zhonghuan West Road, Binhai New Area, Tianjin, 300000 Applicant after: TIANJIN HEMAY PHARMACEUTICAL SCI-TECH Co.,Ltd. Applicant after: Ganzhou Hemei Pharmaceutical Co.,Ltd. Address before: Door 2, Building 12, Huiying Industrial Park, No. 86 Zhonghuan West Road, Binhai New Area, Tianjin, 300000 Applicant before: TIANJIN HEMAY PHARMACEUTICAL SCI-TECH Co.,Ltd. Applicant before: Ganzhou Hemei Pharmaceutical Co.,Ltd. |