CN108096357A - A kind of external preparation for treating wet tinea and preparation method thereof - Google Patents
A kind of external preparation for treating wet tinea and preparation method thereof Download PDFInfo
- Publication number
- CN108096357A CN108096357A CN201810136791.9A CN201810136791A CN108096357A CN 108096357 A CN108096357 A CN 108096357A CN 201810136791 A CN201810136791 A CN 201810136791A CN 108096357 A CN108096357 A CN 108096357A
- Authority
- CN
- China
- Prior art keywords
- parts
- external preparation
- kuh
- seng
- wet tinea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of external preparations for treating wet tinea and preparation method thereof, and the external preparation is mainly prepared by Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis.The external preparation has the effect of dispelling wind and arresting itching, detoxicating and destroying parasites.Available for wet tinea is treated, curative effect is apparent, easily effects a radical cure, treatment cycle is short, without side-effects.
Description
Technical field
The present invention relates to a kind of external preparation for treating wet tinea and preparation method thereof, belong to the field of drug technology.
Technical background
Wet tinea is one of a kind of name of disease, the wet ulcer of skin.《The General Treatise on the Cause and Symptoms of Diseases》Roll up 35：" wet tinea person, also rectify Guo, such as
Worm row, contamination color it is red it is wet itch, the succulence scratched also has worm in it into sore ...." disease mostly because rheumatism heat evil intrusion skin form.Card
See illing skin flush, rotten to the corn, itch is more than, scratches exudation, and contamination face constantly expands, intracutaneous like worm row.
Have currently used for treating the more effective Western medicine of refractory skins such as wet tinea：The immune suppression such as ethyleneimine, bis-morpholine
Preparation；More effective Chinese medicine, such as Keyin pills, Indiginis Naturalis Pill.The main of these existing common drugs is disadvantageous in that：Although energy
Psoriasis is made comparatively fast to disappear, but easily induces other diseases, and it is palliative, it is easy to recur.Its curative effect is not ideal enough,
It is easily recurred after drug withdrawal；Western medicine chemicals side effect is big, and the meeting that long-time service has makes Neuroleptic Leukocytopenia or even causes aregeneratory
Property anaemia, some cause the irreversible lesion such as erythroderma or exfoliative dermatitis.
The content of the invention：
The purpose of the present invention is to provide a kind of external preparation for treating wet tinea and preparation method thereof.The external preparation, which has, dispels
The effect of wind is antipruritic, detoxicating and destroying parasites.Available for wet tinea is treated, curative effect is apparent, easily effects a radical cure, treatment cycle is short, without side-effects.
In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of external preparation for treating wet tinea,
It calculates in parts by weight, mainly by 350-450 parts of Ramulus et Folium Semiliquidambaris cathayensis, 350-450 parts of kuh-seng, 150-250 parts of favus skin, Golden Larch Bark 150-
50-150 parts of 250 parts, 150-250 parts of Cortex Phellodendri and indigo naturalis are prepared.
In the external preparation of the foregoing wet tinea for the treatment of, calculate in parts by weight, mainly by 380-420 parts of Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng
80-120 parts of 380-420 parts, 180-220 parts of favus skin, 180-220 parts of Golden Larch Bark, 180-220 parts of Cortex Phellodendri and indigo naturalis prepare and
Into.
In the external preparation of the foregoing wet tinea for the treatment of, calculate in parts by weight, mainly by 400 parts of Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng 400
100 parts of part, 200 parts of favus skin, 200 parts of Golden Larch Bark, 200 parts of Cortex Phellodendri and indigo naturalis are prepared.
In the external preparation of the foregoing wet tinea for the treatment of, the external preparation is patch or paste.
In the external preparation of the foregoing wet tinea for the treatment of, when the external preparation is patch, matrix is further included, the matrix is pressed
Listed as parts by weight, by 60-80 parts of sorbierite, 70-90 parts of glycerine, 70-90 parts of stearic acid, 60-80 parts of tristearin, yellow petroleum jelly 20-
40 parts, 5-15 parts of sucrose stearate, 15-25 parts of lanolin, 70-90 parts of polysorbate, 3-9 parts of benzoic acid and ethyl hydroxy benzoate 1-
2 parts of compositions.
In the external preparation of the foregoing wet tinea for the treatment of, the matrix calculates by weight, by 65-75 parts of sorbierite, glycerine
75-85 parts, 75-85 parts of stearic acid, 65-75 parts of tristearin, 25-35 parts of yellow petroleum jelly, 8-12 parts of sucrose stearate, lanolin
1.2-1.8 parts of 18-22 parts, 75-85 parts of polysorbate, 5-7 parts of benzoic acid and ethyl hydroxy benzoate form.
In the external preparation of the foregoing wet tinea for the treatment of, the matrix calculates by weight, by 70 parts of sorbierite, glycerine 80
Part, 80 parts of stearic acid, 70 parts stearic, 30 parts of yellow petroleum jelly, 10 parts of sucrose stearate, 20 parts of lanolin, polyoxyethylene sorbitan monoleate part,
1.5 parts of compositions of 6 parts of benzoic acid and ethyl hydroxy benzoate.
In the external preparation of the foregoing wet tinea for the treatment of, the patch is prepared：Comprise the following steps：
（1）Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis, add water to cook it is secondary, for the first time plus 7-9 times measure water, decoct
Boil 1.5-2.5 it is small when, second plus 5-7 times measure water, decoct 1-2 it is small when, collecting decoction, filtration, when filtrate is concentrated into 78-82 DEG C
Relative density is 1.05~1.15 medicinal extract, obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifyings 10-20 minute, 78-82 DEG C keeps the temperature 25-35 minute, addition benzoic acid, ethyl hydroxy benzoate, mixed
It is even, it is filling to get.
In the external preparation of the foregoing wet tinea for the treatment of, the paste is prepared：Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, native chaste tree
Skin, Cortex Phellodendri and indigo naturalis add water to cook 2 times, and for the first time plus 6-10 times is measured water, and when decoction 1.5-2.5 is small, for the second time plus 4-8 times is measured
Water, when decoction 1-2 is small, collecting decoction, filtration, relative density is 1.05~1.15 medicinal extract when filtrate is concentrated into 75-85 DEG C, i.e.,
.
In the external preparation of the foregoing wet tinea for the treatment of, the paste is prepared：Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, native chaste tree
Skin, Cortex Phellodendri and indigo naturalis add water to cook 2 times, and for the first time plus 8 times are measured water, and when decoction 2 is small, for the second time plus 6 times of amount water, decoction 1.5 are small
When, collecting decoction, filtration, when filtrate is concentrated into 75-85 DEG C relative density be 1.05~1.15 medicinal extract to get.
External use plaster of the present invention is prepared by Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis.Its
In, Pterospermi Heterophylli, Chinese medicine name.For the root of Sterculiaceae plant pterospermum heterophyllum Hance or stem branch, nature and flavor：It is sweet in flavor, it is warm-natured.Effect：Wind-damp dispelling,
Relaxing tendons and activating collaterals.It cures mainly：For rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lumbocrural pain, hemiplegia, bruise
Damage, bruise；Bleeding on knife is controlled in external application.Kuh-seng, Chinese medicine name.For the dry root of legume kuh-seng, nature and flavor：Bitter, it is cold in nature.
Channel tropism：The thoughts of returning home, liver, stomach, large intestine, bladder warp.Effect：Heat-clearing and damp-drying drug, desinsection, diuresis.It cures mainly：For hot dysentery, have blood in stool, jaundice urine
It closes, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy controls trichomonas vaginitis outside.Favus skin, for many years
Raw perennial root draft, complete stool have strong aroma.Favus skin, perennial herb, complete stool have strong aroma.Nature and flavor：It is bitter salty, it trembles with fear.
Channel tropism：Enter spleen, stomach.With the effect of heat-clearing and damp-drying drug, wind-dispelling is detoxified, for damp and hot sore, yellow water is dripping, eczema, rubella, scabies
The diseases such as tinea sore La, beriberoid pyretic arthralgia, jaundice.Golden Larch Bark is pinaceae plant golden larch（Pseudolarix kamepferi
Gord.）Dry root skin or near root bark.【Nature and flavor】It is acrid in flavour and warm in nature；It is toxic.【Channel tropism】Return lung, the spleen channel.【Effect】Desinsection, it is antipruritic.
【It cures mainly】Control mange itch.Cortex Phellodendri（huáng bò）, Chinese medicine name.For rutaceae wampee Phellodendron
The dry bark of chinense Schneid..Nature and flavor：Bitter, it is cold in nature.Channel tropism：Kidney, bladder warp.There is heat-clearing and damp-drying drug, purging intense heat removes
The effect of steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, hectic fever due to yin labor heat,
Night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.Indigo naturalis, Chinese medicine name.
For justicia reward section plant acanthaceous indigo, polygonaceae plant indigo plant, the leaf of cruciferae isatis or the processed xeraphium obtained of cauline leaf
End, agglomerate or particle.Nature and flavor：It is salty, it trembles with fear.Channel tropism：Return liver warp.Effect：It is clearing heat and detoxicating, blood cooling and ecchymoses removing, purging intense heat arresting convulsion.It cures mainly：Temperature
Poison hair spot, blood-head tells nosebleed, pectoralgia hemoptysis, aphtha, mumps, larynx numbness, pediatric epilepsy scared.
External preparation is made using above-mentioned raw materials in the present invention, and Ramulus et Folium Semiliquidambaris cathayensis gas is micro- in side, puckery, there is dispelling wind and eliminating dampness effect, uses
In rubella, pruitus；Kuh-seng bitter, cold in nature, this grade bitterness is trembled with fear, the most clear dry, can wind-dispelling poison, clearing away damp-heat, detumescence poison kill
Sarcoptic mite；The two is monarch drug in a prescription altogether.Favus skin is bitter, cold, eliminating dampness heat-clearing, dispelling wind and arresting itching, the product commonly used for damp and hot sore；Golden Larch Bark taste
It is pungent, warm-natured, there is Anti-Puritic and insecticidal, treat the benefits of tinea, be altogether ministerial drug.Cortex Phellodendri bitter, it is cold in nature, it can eliminating dampness heresy；Indigo naturalis is salty, cold, can heat-clearing
Detoxify, control wet tinea；It is adjuvant altogether.The benefits of all medicine phases 5, gather dispelling wind and arresting itching altogether, detoxicating and destroying parasites.
When the present invention prepares patch, matrix used is stearic by sorbierite, glycerine, stearic acid, tristearin, yellow petroleum jelly, sucrose
Acid esters, lanolin, polysorbate, benzoic acid and ethyl hydroxy benzoate are prepared.Wherein, D-sorbite, alias sorbierite.English name
Sorbitol、D-Glucitol、Sorbol、D-Sorbitol.Molecular formula is C6H14O6, molecular weight 182.17.It is inhaled for white
Moist powder or crystalline powder, sheet or particle, it is odorless, as toothpaste, cosmetics, tobacco conditioning agent.Glycerine, colourless, nothing
Smelly, sweet, appearance is in clear and bright viscous liquid state, is a kind of organic matter.In terms of medicine, to produce various preparations, solvent, moisture absorption
Agent, antifreezing agent and sweetener, ingredients externally-applied ointment or suppository etc..Stearic acid, i.e. octadecanoid acid are widely used in inhibition and generation cosmetic, modeling
Expect cold resistant plasticizer, releasing agent, stabilizer, surfactant, thiofide, waterproofing agent, polishing agent, metallic soap, gold
Belong to mineral flotation agent, softening agent, pharmaceuticals and other organic chemicals.Tristearin is a kind of chemical substance, and molecular formula is
C57H110O6, as food emulsifying agent.It is also used for cosmetics, the industries such as soap and candle.Yellow petroleum jelly is faint yellow or yellow
Uniform soft paste；It is odorless or almost odorless；There is soapy feeling with skin contact；Sucrose stearate, English name:
Sucrose stearate ester, colourless or slight- yellow thick liquid or powder, it is tasteless, water is slightly soluble in, is dissolved in ethyl alcohol；It can make
Emulsifier, wetting agent, dispersant, solubilizer and emollient etc..Make emulsifier for cosmetics, food, medical industry, make food
Dosage is 1~1.5g/kg when emulsifier and food preservative.It can be additionally used in detergent, fiber process, farming and animal husbandry and tin product
Deng.Lanolin is attached to a kind of secretion grease on wool, is faint yellow or brown color soft paste；There is stickiness and slide
It is greasy；It is smelly faint and special.It is readily soluble in chloroform or ether, it is dissolved in hot ethanol, in ethanol soluble,very slightly.Lanolin can be with
Make skin smooth tender.It is pharmaceutically used to prepare plaster for curing rheumatism, zinc oxide adhesive plaster and ointment base.Cosmetics-stage lanolin can use
In cold cream, crease-proof cream, chapstick, shampoo paste, hair conditioner, hair-cream, lipstick and advanced perfumed soap etc..It is commonly used for water-in-oil emulsion
Agent is excellent moistness substance.The dry or rough skin when lacking natural moisture can be made to soften and be restored.Poly- mountain
Pear ester is faint yellow to orange-yellow thick liquid, and a sense of warmth is used as the solubilizer or emulsifier of parenteral solution and oral liquid；Glue
Wafer dispersant；Ointment emulsifier and matrix；Suppository base etc..It is used as emulsifier in the food industry.Benzoic acid
For flakey or acicular crystal with benzene or the smell of formaldehyde, benzoic acid can make Whitfield's Ointment, benzoic acid
Unguentum acidi salicylici is the medicament made of addition lanolin, yellow petroleum jelly using benzoic acid, salicylic acid as primary raw material.Wherein, benzene first
Acid is combined with salicylic acid, can treat adult skin nosomycosis, the mycotic infection of superficial part such as diseases such as ringworm of the body, the tinea manuum and tinea pedis.4-
Nipagin A, for white crystalline powder, the preservative as food, drug and cosmetics.
The present invention uses more than raw material that medicinal plaster stroma is made according to present invention proportioning, the medicine paste made of the matrix
Agent plasticity is good, without pullling dermal sensation when movable, and is easily peeled off, painless, skin situation without exception after stripping.
Treat example statistics
1 patient and method
The 1.1 wet tinea patients of patient 38, man 22, female 16；It is 27-70 years old ages, 47 years old average.
1.2 therapy
1.2.1 drug 1 of the present invention is smeared（It is prepared by embodiment 1）3 times a day.
1.2.2 course for the treatment of 20d is the observation time limit.
1.3 observation index observe the variations such as pretherapy and post-treatment pruitus, erosion.
1.4 effective standards are cured：Pruitus, illing skin flush, rotten to the corn, itch is more than, scratches exudation, leaching
Excessive face constantly expands, intracutaneous to be lost completely like symptoms such as worm rows.Effectively：More than remission or mitigation, affected part appearance parts recover
Normally；It is invalid：Symptom is not improved.
2 results
Curative effect
After treatment 20 days, Cure is counted, the results are shown in Table 1.
By table 1 as it can be seen that drug of the present invention can treat the pruitus of wet tinea breaking-out, illing skin flush, rotten to the corn, itch is not
Only, exudation is scratched, contamination face constantly expands, intracutaneous like worm row etc., curative effect affirmative.
3 certain embodiments
Liu, female, 38 years old, eczema patients 1 year, illing skin flush, rotten to the corn, itch was more than, scratches exudation.Use this hair
Bright drug is after 10 days, hence it is evident that improves, itch and erosion are substantially reduced, recover completely after 20 days, illing skin flush, rotten to the corn, scabies
Itch more than, scratch exudation disappearance.
Mr. Wang, male, 35 years old, eczema patients 3 months, pruitus, illing skin flush.After drug of the present invention 20 days
Recover completely, pruitus and illing skin flush disappear.
Liu, man, 25 years old, eczema patients 1 year, illing skin flush, rotten to the corn, itch was more than, scratches exudation, contamination
Face constantly expands, intracutaneous like worm row.Recovered completely after 20 days using drug of the present invention, no tenderness, sense of discomfort disappears.
Liu, female, 37 years old, eczema patients 1 year.Illing skin flush, rotten to the corn, itch is more than, scratches exudation, contamination
Face constantly expands, intracutaneous like worm row.Recovered completely after 20 days using drug of the present invention, no tenderness, sense of discomfort disappears.
Mr. Wang, 52 years old, eczema patients 1 year, illing skin flush, rotten to the corn, itch was more than, scratches exudation.Use this
After invention drug 10 days, hence it is evident that it improves, itch and erosion are substantially reduced, recover completely after 20 days, illing skin flush, rotten to the corn,
Itch is more than, scratches exudation disappearance.
Experimental example 2：Performance study
1 research project：Drug of the present invention is made by embodiment 1.
2 viscosities are tested.
Hold the measure of viscous force by《Chinese Pharmacopoeia》2010 editions Ⅹ II E emplastrums of an annex stick amylograph（Second
Method holds the measure of viscous force）It measures, the results are shown in Table 3；
Peel strength is pressed《Chinese Pharmacopoeia》2010 editions Ⅹ II E emplastrums of an annex stick amylograph（3rd method is removed strong
The measure of degree）It measures, the results are shown in Table 2.
Conclusion：Drug viscosity of the present invention meets the requirements, and stickiness is moderate, and lotion plasticity is preferable, and affinity is strong, to skin irritatin
Property is small.
3 skin irritation tests.
Please 20 professionals carry out it is blank feel scoring, hundred-mark system takes geometrical mean.It the results are shown in Table 3.
Scoring such as table 5：
As seen from table, pharmaceutical properties of the present invention are good.
Compared with prior art, the present invention has the effect of dispelling wind and arresting itching, detoxicating and destroying parasites.Available for treating wet tinea.This hair
Medicine patch plasticity is good made of bright medicinal plaster stroma, without pullling dermal sensation when movable, and is easily peeled off, painless,
Skin situation without exception after stripping.Using patch made of medicinal plaster stroma of the present invention, not only with dispelling wind and arresting itching, poison is attacked
The effect of desinsection, also has the characteristics that work rapid, eutherapeutic.
Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.
Specific embodiment：
Embodiment 1
Drug extract formula：Ramulus et Folium Semiliquidambaris cathayensis 400g, kuh-seng 400g, favus skin 200g, Golden Larch Bark 200g, Cortex Phellodendri 200g and indigo naturalis
100g。
Matrix formulations：Sorbierite 70g, glycerine 80g, stearic acid 80g, tristearin 70g, yellow petroleum jelly 30g, sucrose stearate
10g, lanolin 20g, polyoxyethylene sorbitan monoleate g, benzoic acid 6g and ethyl hydroxy benzoate 1.5g.
Patch manufacture craft：Comprise the following steps：
（1）Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis add water to cook secondary, first time plus 8 times of amount water, decoction
2 it is small when, second plus 6 times of amount water, decoct 1.5 it is small when, collecting decoction, filtration, relative density is when filtrate is concentrated into 78-82 DEG C
1.05~1.15 medicinal extract obtains drug extract, i.e. A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 15 minutes, 78-82 DEG C keeps the temperature 30 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress to get.
Usage and dosage：External application, is applied to affected part, and each 4-6h is smeared once.
Embodiment 2
Drug extract formula：Ramulus et Folium Semiliquidambaris cathayensis 420g, kuh-seng 420g, favus skin 220g, Golden Larch Bark 220g, Cortex Phellodendri 220g and indigo naturalis
120g。
Matrix formulations：Sorbierite 75g, glycerine 85g, stearic acid 85g, tristearin 75g, yellow petroleum jelly 35g, sucrose stearate
12g, lanolin 22g, polysorbate 85 g, benzoic acid 7g and ethyl hydroxy benzoate 1.8g.
Patch manufacture craft：Comprise the following steps：
（1）Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis add water to cook secondary, first time plus 9 times of amount water, decoction
2.5 it is small when, second plus 7 times of amount water, decoct 2 it is small when, collecting decoction, filtration, relative density is when filtrate is concentrated into 78-82 DEG C
1.05~1.15 medicinal extract obtains drug extract, i.e. A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 20 minutes, 78-82 DEG C keeps the temperature 35 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress to get.
Usage and dosage：External application, is applied to affected part, and each 4-6h is smeared once.
Embodiment 3
Paste ingredient：Ramulus et Folium Semiliquidambaris cathayensis 380g, kuh-seng 380g, favus skin 180g, Golden Larch Bark 180g, Cortex Phellodendri 180g and indigo naturalis 80g.
Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis add water to cook secondary, first time plus 7 times of amount water, pan-fried
Boil 1.5 it is small when, second plus 5 times of amount water, decoct 1 it is small when, collecting decoction, filtration, relative density when filtrate is concentrated into 78-82 DEG C
For 1.05~1.15 medicinal extract to get.
Claims (10)
1. a kind of external preparation for treating wet tinea, it is characterised in that：Calculate in parts by weight, mainly by 350-450 parts of Ramulus et Folium Semiliquidambaris cathayensis,
50-150 parts of 350-450 parts of kuh-seng, 150-250 parts of favus skin, 150-250 parts of Golden Larch Bark, 150-250 parts of Cortex Phellodendri and indigo naturalis preparations
It forms.
2. the external preparation of wet tinea is treated as described in claim 1, it is characterised in that：It calculates in parts by weight, mainly by half
380-420 parts of wind lotus, 380-420 parts of kuh-seng, 180-220 parts of favus skin, 180-220 parts of Golden Larch Bark, 180-220 parts of Cortex Phellodendri and green grass or young crops
80-120 parts of black pigment used by women in ancient times to paint their eyebrows is prepared.
3. the external preparation of wet tinea is treated as claimed in claim 2, it is characterised in that：It calculates in parts by weight, mainly by half
100 parts of 400 parts of wind lotus, 400 parts of kuh-seng, 200 parts of favus skin, 200 parts of Golden Larch Bark, 200 parts of Cortex Phellodendri and indigo naturalis are prepared.
4. the external preparation of the wet tinea for the treatment of as any one of claim 1-3, it is characterised in that：The external preparation is
Patch or paste.
5. the external preparation of wet tinea is treated as claimed in claim 4, it is characterised in that：When the external preparation is patch, also
Including matrix, the matrix calculates by weight, by 60-80 parts of sorbierite, 70-90 parts of glycerine, 70-90 parts of stearic acid, tristearin
60-80 parts, 20-40 parts of yellow petroleum jelly, 5-15 parts of sucrose stearate, 15-25 parts of lanolin, 70-90 parts of polysorbate, benzene first
Sour 3-9 parts and 1-2 parts of compositions of ethyl hydroxy benzoate.
6. the external preparation of the wet tinea for the treatment of as described in claim requirement 5, it is characterised in that：The matrix is by weight
It calculates, by 65-75 parts of sorbierite, 75-85 parts of glycerine, 75-85 parts of stearic acid, 65-75 parts of tristearin, 25-35 parts of yellow petroleum jelly, sucrose
1.2-1.8 parts of 8-12 parts of stearate, 18-22 parts of lanolin, 75-85 parts of polysorbate, 5-7 parts of benzoic acid and ethyl hydroxy benzoate groups
Into.
7. the external preparation of the wet tinea for the treatment of as described in claim requirement 6, it is characterised in that：The matrix is by weight
It calculates, by 70 parts of sorbierite, 80 parts of glycerine, 80 parts of stearic acid, 70 parts stearic, 30 parts of yellow petroleum jelly, 10 parts of sucrose stearate, sheep
1.5 parts of 20 parts of fat of hair, polyoxyethylene sorbitan monoleate part, 6 parts of benzoic acid and ethyl hydroxy benzoate compositions.
8. the external preparation of the wet tinea for the treatment of as any one of claim 5-7, it is characterised in that：The patch is so made
It is standby：Comprise the following steps：
（1）Ramulus et Folium Semiliquidambaris cathayensis, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis, add water to cook it is secondary, for the first time plus 7-9 times measure water, decoct
Boil 1.5-2.5 it is small when, second plus 5-7 times measure water, decoct 1-2 it is small when, collecting decoction, filtration, when filtrate is concentrated into 78-82 DEG C
Relative density is 1.05~1.15 medicinal extract, obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifyings 10-20 minute, 78-82 DEG C keeps the temperature 25-35 minute, addition benzoic acid, ethyl hydroxy benzoate, mixed
It is even, it is filling to get.
9. the external preparation of wet tinea is treated as claimed in claim 4, it is characterised in that：The paste is prepared：Half wind
Lotus, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis add water to cook 2 times, and for the first time plus 6-10 times is measured water, and it is small to decoct 1.5-2.5
When, for the second time plus 4-8 times is measured water, and when decoction 1-2 is small, collecting decoction, filtration, relative density is when filtrate is concentrated into 75-85 DEG C
1.05~1.15 medicinal extract to get.
10. the external preparation of wet tinea is treated as claimed in claim 9, it is characterised in that：The paste is prepared：Half wind
Lotus, kuh-seng, favus skin, Golden Larch Bark, Cortex Phellodendri and indigo naturalis add water to cook 2 times, and for the first time plus 8 times are measured water, when decoction 2 is small, second
Add 6 times of amount water, when decoction 1.5 is small, collecting decoction, filtration, relative density is 1.05~1.15 when filtrate is concentrated into 75-85 DEG C
Medicinal extract to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810136791.9A CN108096357A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating wet tinea and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810136791.9A CN108096357A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating wet tinea and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108096357A true CN108096357A (en) | 2018-06-01 |
Family
ID=62205551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810136791.9A Pending CN108096357A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating wet tinea and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108096357A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547188A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | External preparation for treating varicosity and preparation method thereof |
-
2018
- 2018-02-09 CN CN201810136791.9A patent/CN108096357A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547188A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | External preparation for treating varicosity and preparation method thereof |
Non-Patent Citations (7)
| Title |
|---|
| 《中医大辞典》编辑委员会: "《简明中医辞典》", 30 June 1986, 人民卫生出版社 * |
| 张彬等: "苦黄水剂湿敷治疗急性炎症反应性皮肤病56例", 《中医外治杂志》 * |
| 张树生等: "《中药临床鉴用指迷》", 30 June 1989, 中医古籍出版社 * |
| 杨卫平等: "《特色中草药及配方2》", 31 August 2016, 贵州科技出版社 * |
| 梅全喜: "《广东地产药材研究》", 31 May 2011, 广东科技出版社 * |
| 钟赣生: "《中药学》", 31 January 2013, 中国中医药出版社 * |
| 陈德兴: "《中成药学》", 31 July 2009, 上海科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101445010B1 (en) | Antiphlogistic, antioncotic and analgesic chinese herbal composition, preparative method and usage thereof | |
| CN101804166B (en) | Traditional Chinese medicine composition for treating dermatitis and eczema of infants | |
| CN103041173B (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN103611133B (en) | Promoting blood circulation and stopping pain gel and preparation method thereof | |
| CN105596587A (en) | Composition for relieving swelling and pain | |
| CN108567852A (en) | A kind of pharmaceutical composition of prevention diabetic neuropathy | |
| CN108096357A (en) | A kind of external preparation for treating wet tinea and preparation method thereof | |
| CN105616536A (en) | Traditional Chinese medicine liniment for treating leukoderma | |
| CN103054991B (en) | Traditional Chinese medicine composition for treating lower abdominal discomfort, as well as preparation method and use thereof | |
| CN106421283A (en) | Traditional Chinese medicine ointment for treating skin diseases | |
| CN107468962B (en) | It is a kind of to be used to treat external medicine composition of milk cow mange and scab and preparation method thereof | |
| CN105055685A (en) | Ointment for treating chilblain and preparation method of ointment | |
| CN111000913A (en) | Traditional Chinese medicine composition for treating psoriasis | |
| CN110051761A (en) | Topical agent of acne-removing inflammation-diminishing and preparation method thereof | |
| CN104352705A (en) | Drug composition for treating lobular hyperplasia of mammary glands and preparation method thereof | |
| KR101611966B1 (en) | Production of antlers and medicinal herbs extract for arthritis care medicine | |
| CN115671239B (en) | Anti-inflammatory, detumescence, antibacterial, antipruritic, anticracking and repairing jelly-curing cream and preparation method thereof | |
| CN115414427B (en) | Traditional Chinese medicine composition for treating chronic skin pruritus and preparation method and application thereof | |
| CN108186761A (en) | A kind of external preparation for treating hemorrhoid and preparation method thereof | |
| CN107714834A (en) | A kind of composition of camellia oil preparation for external use, preparation method and applications | |
| CN106309589A (en) | Medicine for treating cutaneous pruritus and preparation method thereof | |
| CN104784666A (en) | Traditional Chinese medicine ointment for orthopedic nursing | |
| CN105168779A (en) | Pharmaceutical preparation for treating skin allergy | |
| CN110025728A (en) | A kind of Chinese medicine ointment and its preparation process for treating burn and scald |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180601 |
|
| RJ01 | Rejection of invention patent application after publication |