CN108186761A - A kind of external preparation for treating hemorrhoid and preparation method thereof - Google Patents
A kind of external preparation for treating hemorrhoid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of external preparation for treating hemorrhoid and preparation method thereof, the external preparation is prepared by Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake and borneol.The present invention has the effect of cooling blood and hemostasis, swelling and pain relieving.Available for treatment piles, external piles and anal inflammation etc., and curative effect is apparent, easily effects a radical cure, treatment cycle is short, Small side effects.
Description
Technical field
The present invention relates to a kind of external preparations for treating hemorrhoid and preparation method thereof, belong to the field of drug technology.
Technical background
Hemorrhoid are also known as hemorrhoid disease, haemorrhoids, haemorrhoids, are to be expanded under the mucous membrane of human rectum end with veniplex under anal canal skin
The soft venous group formed with buckling, hemorrhoid include internal piles, external piles, mixed hemorrhoid, are anal orifice and rectal intestine bottom and anal mucosa
A kind of chronic disease of the venous group of one or more softness that veniplex occurs varicose and formed.Positioned at the blood vessel group of anal canal
It knits, when its swelling or inflammation, can take on morbit forms or become hemorrhoid.For its physiology and appearance, it be by arteriovenous channel and
The anus pad of connective tissue composition.Hemorrhoid（It is commonly called as hemorrhoid）It is a kind of common disease positioned at anus area, any age can all fall ill,
But with age, incidence gradually increases.In China, hemorrhoid are most common anorectal diseases, are known as " ten male nine hemorrhoid ", " ten
The saying of ten hemorrhoid of female ".In the U.S., the incidence of hemorrhoid is about 5%.
Hemorrhoid are the common diseases of people, and frequently-occurring disease, mostly because of damp and hot wind-dryness of experiencing, hemostasis stagnates caused by anus.Hemorrhoid
Incidence accounts for the 87.25% of anal intestine disease, there is being commonly called as ten people, nine hemorrhoid.The breaking-out of its hemorrhoid is because the anus pad tissue of anus part is by certain
Kind undesirable element stimulates and congestion and edema, blood vessel dilatation, and caused by hypostasis, great pain is caused to the live and work of patient
It is bitter.
The method for the treatment of hemorrhoid common at present, doctor trained in Western medicine is generally using operative treatment, but in this way, patient will bear
By very big pain and psychological pressure.The traditional Chinese medical science is generally using clearing and activating the channels and collaterals, and promoting blood circulation and removing blood stasis, the various Chinese medicines of analgesic hemostatic are matched
Into drug.These medicaments are divided into oral drugs and external used medicine.But the external preparation for the treatment of hemorrhoid sold currently on the market, is controlled
The treatment period is long, and is not easy to effect a radical cure, and to external piles curative effect also unobvious, side effect is big.
Invention content：
The purpose of the present invention is to provide a kind of external preparation for treating hemorrhoid and preparation method thereof.The present invention has cooling blood and hemostasis,
The effect of swelling and pain relieving.Available for treatment piles, external piles and anal inflammation etc., and curative effect is apparent, easily effects a radical cure, and treatment cycle is short,
Small side effects.
In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of external preparation for treating hemorrhoid,
The external preparation is calculated in parts by weight, by 350-450 parts of Liu Jisheng, 350-450 parts of charred RADIX SANGUISORBAE, 250-350 parts of calcined gypsum,
40-60 parts of 100-200 parts of saltcake and borneol are prepared.
In the external preparation of aforementioned treatment hemorrhoid, the external preparation is calculated in parts by weight, by Liu Jisheng 380-420
Part, 380-420 parts of charred RADIX SANGUISORBAE, 280-320 parts of calcined gypsum, 130-170 parts of saltcake and 45-55 parts of borneol are prepared.
In the external preparation of aforementioned treatment hemorrhoid, the external preparation is calculated in parts by weight, by 400 parts of Liu Jisheng,
50 parts of 400 parts of charred RADIX SANGUISORBAE, 300 parts of calcined gypsum, 150 parts of saltcake and borneol are prepared.
In the external preparation of aforementioned treatment hemorrhoid, the external preparation is patch or paste.
In the external preparation of aforementioned treatment hemorrhoid, when the external preparation is patch, matrix, the matrix are further included
It calculates by weight, by 60-80 parts of sorbierite, 70-90 parts of glycerine, 70-90 parts of stearic acid, 60-80 parts of tristearin, yellow petroleum jelly
20-40 parts, 5-15 parts of sucrose stearate, 15-25 parts of lanolin, 70-90 parts of polysorbate, 3-9 parts of benzoic acid and oxybenzene second
1-2 parts of compositions of ester.
In the external preparation of aforementioned treatment hemorrhoid, the matrix calculates by weight, by 65-75 parts of sorbierite, glycerine
75-85 parts, 75-85 parts of stearic acid, 65-75 parts of tristearin, 25-35 parts of yellow petroleum jelly, 8-12 parts of sucrose stearate, lanolin
1.2-1.8 parts of 18-22 parts, 75-85 parts of polysorbate, 5-7 parts of benzoic acid and ethyl hydroxy benzoate form.
In the external preparation of aforementioned treatment hemorrhoid, the matrix calculates by weight, by 70 parts of sorbierite, glycerine 80
Part, 80 parts of stearic acid, 70 parts stearic, 30 parts of yellow petroleum jelly, 10 parts of sucrose stearate, 20 parts of lanolin, polyoxyethylene sorbitan monoleate part,
1.5 parts of compositions of 6 parts of benzoic acid and ethyl hydroxy benzoate.
In the external preparation of aforementioned treatment hemorrhoid, the patch is prepared：Include the following steps：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake, add water to cook secondary, and for the first time plus 7-9 times is measured water, and it is small to decoct 1.5-2.5
When, for the second time plus 5-7 times is measured water, is decocted 1-2 hours, collecting decoction, filtrate adds in borneol and is simultaneously concentrated into relatively close at 78-82 DEG C
The medicinal extract for 1.05~1.15 is spent, obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifyings 10-20 minute, 78-82 DEG C keeps the temperature 25-35 minute, addition benzoic acid, ethyl hydroxy benzoate, mixed
It is even, it is filling to get.
In the external preparation of aforementioned treatment hemorrhoid, the patch is prepared：Include the following steps：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake, add water to cook it is secondary, for the first time plus 8 times amount water, decoct 2 hours, second
Secondary plus 6 times of amount water, decoct 1.5 hours, collecting decoction, filtration, relative density is when filtrate adds in borneol and is concentrated into 78-82 DEG C
1.05~1.15 medicinal extract obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 15 minutes, 78-82 DEG C keeps the temperature 30 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress to get.
In the external preparation of aforementioned treatment hemorrhoid, the paste is prepared：Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, awns
Nitre adds water to cook 2 times, and for the first time plus 8 times of amount water, decoction 2 hours, second plus 6 times of amount water decoct 1.5 hours, merging is decocted
Liquid, filtrate add in borneol and when being concentrated into 78-82 DEG C relative density be 1.05~1.15 medicinal extract to get.
Drug extract of the present invention is prepared by Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake and borneol.Wherein, willow
Parasitism is Chinese ilex（Ilex chinensis Sims）, smell：（Son and wood skin）It is sweet, bitter, cool, nontoxic.It goes wind empty, controls hemorrhoid.Leaf
Ashing can control chapped skin, scar of going out.Charred RADIX SANGUISORBAE, Chinese medicine name.Preparation process product for garden burnet；Nature and flavor：It is bitter, sour, puckery, it is slightly cold.
Channel tropism：Return liver, large intestine channel.Effect：Cooling blood and hemostasis, removing toxic substances sore.It cures mainly：For having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, extreme misery scalds
Wound, carbuncle sore tumefacting virus.Powder or loose block of the calcined gypsum for white, surface appears the gloss of blush, opaque.Body compared with
Gently, matter is soft, frangible, pinch into powder.It is odorless, it is lightly seasoned.【Meridian distribution of property and flavor】It is sweet, pungent, puckery, it trembles with fear.It attaches to the lung and stomach meridians；【Major function】It receives
It is wet, myogenic, sore, hemostasis.Control unhealing ulcer, eczema itch, scald, traumatic hemorrhage outside.Saltcake, Chinese medicine name.For sulfuric acid
Saline minerals saltcake race saltcake, the processed refined crystalline solid formed；With relieving constipation by purgation, moistening for dryness and softening hard mass, the work(for detumescence of relieving inflammation or internal heat
Effect.It is usually used in real heat to stagnate, abdomen expires the treatment of the illnesss such as distending pain, dry feces, acute appendicitis swelling and pain；Control acute mastitis, hemorrhoid gall outside；Property
Taste：Taste is salty, bitter, cold in nature.Channel tropism：Return stomach, large intestine channel.Borneol, nature and flavor：It is pungent, bitter, it is slightly cold.Channel tropism：The thoughts of returning home, spleen, lung channel.It can
For closing card coma, for red eye, swell pain, larynx numbness aphtha, for sore swell and ache curative is not held back after bursting.
External preparation is made using above-mentioned raw materials in the present invention, its property bitter cold of Liu Jisheng in side, has cool blood, hemostasis, removing toxic substances are held back
The work(of sore；Charred RADIX SANGUISORBAE is bitter, acid, is slightly cold, go down it is burnt, enter blood system, clear drop cool blood, controlling of bleeding with astringents after forging, but only let out clearly, it is puckery and
It is not stagnant；The two is monarch drug in a prescription altogether.Gypsum is pungent, Great Cold, after this product is forged, tepor and it is puckery, can saprophytic removing, hygroscopic sore, detumescence stops
Blood is ministerial drug；Saltcake is pungent salty, and Great Cold, bitter gas is trembled with fear, and walks without keeping, salty with softening hard masses；Borneol clearing away heat to and alleviating pain is altogether adjuvant.Five
The effect of taste medicine phases 5, gather cooling blood and hemostasis altogether, swelling and pain relieving.
Medicinal plaster stroma of the present invention is by sorbierite, glycerine, stearic acid, tristearin, yellow petroleum jelly, sucrose stearate, sheep
Hair fat, polysorbate, benzoic acid and ethyl hydroxy benzoate are prepared.Wherein, D-sorbite, alias sorbierite.English name
Sorbitol、D-Glucitol、Sorbol、D-Sorbitol.Molecular formula is C6H14O6, molecular weight 182.17.It is inhaled for white
Moist powder or crystalline powder, sheet or particle, it is odorless, as toothpaste, cosmetics, tobacco conditioning agent.Glycerine, colourless, nothing
Smelly, sweet, appearance is in clear and bright viscous liquid state, is a kind of organic matter.In terms of medicine, to produce various preparations, solvent, moisture absorption
Agent, antifreezing agent and sweetener, ingredients externally-applied ointment or suppository etc..Stearic acid, i.e. octadecanoid acid are widely used in inhibition and generation cosmetic, modeling
Expect cold resistant plasticizer, releasing agent, stabilizer, surfactant, thiofide, waterproofing agent, polishing agent, metallic soap, gold
Belong to mineral flotation agent, softening agent, pharmaceuticals and other organic chemicals.Tristearin is a kind of chemical substance, and molecular formula is
C57H110O6, as food emulsifying agent.It is also used for cosmetics, the industries such as soap and candle.Yellow petroleum jelly is faint yellow or yellow
Uniform soft paste；It is odorless or almost odorless；There is soapy feeling with skin contact；Sucrose stearate, English name:
Sucrose stearate ester, colourless or slight- yellow thick liquid or powder, it is tasteless, water is slightly soluble in, is dissolved in ethyl alcohol；It can make
Emulsifier, wetting agent, dispersant, solubilizer and emollient etc..Make emulsifier for cosmetics, food, medical industry, make food
Dosage is 1~1.5g/kg when emulsifier and food preservative.It can be additionally used in detergent, fiber process, farming and animal husbandry and tin product
Deng.Lanolin is attached to a kind of secretion grease on wool, is faint yellow or brown color soft paste；There is stickiness and slide
It is greasy；It is smelly faint and special.It is readily soluble in chloroform or ether, it is dissolved in hot ethanol, in ethanol soluble,very slightly.Lanolin can be with
Make skin smooth tender.It is pharmaceutically used to prepare plaster for curing rheumatism, zinc oxide adhesive plaster and ointment base.Cosmetics-stage lanolin can be used
In cold cream, crease-proof cream, chapstick, shampoo paste, hair conditioner, hair-cream, lipstick and advanced perfumed soap etc..It is commonly used for water-in-oil emulsion
Agent is excellent moistness substance.The dry or rough skin when lacking natural moisture can be made to soften and be restored.Poly- mountain
Pear ester is faint yellow to orange-yellow thick liquid, and a sense of warmth is used as the solubilizer or emulsifier of parenteral solution and oral liquid；Glue
Wafer dispersant；Ointment emulsifier and matrix；Suppository base etc..It is used as emulsifier in the food industry.Benzoic acid
For flakey or acicular crystal with benzene or the smell of formaldehyde, benzoic acid can make Whitfield's Ointment, benzoic acid
Unguentum acidi salicylici is the medicament made of addition lanolin, yellow petroleum jelly using benzoic acid, salicylic acid as primary raw material.Wherein, benzene first
Acid is combined with salicylic acid, can treat adult skin nosomycosis, the mycotic infection of superficial part such as diseases such as ringworm of the body, the tinea manuum and tinea pedis.4-
Nipagin A, for white crystalline powder, the preservative as food, drug and cosmetics.
The present invention uses more than raw material that medicinal plaster stroma is made according to present invention proportioning, the medicine paste made of the matrix
Agent plasticity is good, without pullling dermal sensation, and be easily peeled off when movable, painless, skin situation without exception after stripping.
Treat example statistics
1 patient and method
1.1 patients 33 exception hemorrhoid (inflammatory external hemorrhoid, varication external piles, thrombosed external hemorrhoid) patient, man 17, female 16；Age
It is 27-70 years old, 47 years old average.
1.2 therapy
1.2.1 drug 1 of the present invention is smeared（It is prepared by embodiment 1）3 times a day.
1.2.2 course for the treatment of 20d is the observation time limit.
1.3 observation index observation pretherapy and post-treatment anus part subjective symptoms (falling inflation, pain, it is scorching hot, have blood in stool and constipation)
With the situation of change of anus appearance symptom (hyperemia, oedema, abjection, erosion and bleeding).
1.4 effective standard is cured：Symptom completely disappears, and anus appearance restores normal；Effectively：Remission or mitigation,
Anus appearance parts restore normal；In vain：Symptom is not improved.
2 results
2.1 pretherapy and post-treatment symptom improvement, which are compared, is shown in Table 1.
By table l as it can be seen that using after drug of the present invention, in anus subjective symptoms (pain, falling inflation and have blood in stool) and anus appearance symptom
Can preferably it be improved in terms of (oedema, abjection and erosion).
2.2 curative effect
After treatment 20 days, Cure is counted, the results are shown in Table 2.
As can be seen from Table 2, drug of the present invention can treat the extravasated blood oedema of hemorrhoid breaking-out, pain, bleeding, erosion, constipation and de-
Go out, curative effect affirmative.
3 certain embodiments
Liu, female, 38 years old, podex cusalgia, it is wet itch, anus pleat has a small amount of secretion.It is bright after drug of the present invention 10 days
It is aobvious to improve, pain and it is wet itch substantially reduced, anus pleat restores, pain and wet disappearance of itching completely without secretion after 20 days.
Mr. Wang, male, 35 years old, the paranal swollen object of protuberance, accessible subcutaneous hard and sliding mass was touched a tender spot apparent.Use the present invention
Drug restores completely after 20 days, swells swollen object and disappears, no tenderness.
Liu, man, 25 years old, the swollen object of the paranal protuberance of toposcopy had tenderness, sometimes can be with general malaise and fever.
Restored completely after 20 days using drug of the present invention, swell swollen object and disappear, no tenderness, sense of discomfort disappears.
Liu, female, 37 years old, podex cusalgia, it is wet itch, anus pleat has a small amount of secretion.Use drug of the present invention 10 days
Afterwards, hence it is evident that improve, pain and it is wet itch substantially reduced, anus pleat restores, pain and wet itch disappear completely without secretion after 20 days
It loses.
Mr. Wang, 52 years old, anal orifice had mulberry ellipse to swell object, and severe pain is felt restless, and used drug of the present invention 10 days
Afterwards, hence it is evident that improve, pain relief, swollen object becomes smaller, restores completely after 20 days, painless, and the object that swells disappears.
Pacify certain, 27 years old, female, anal orifice had brown ellipse to swell object, there is rectal tenesmus sense, used drug of the present invention 20 days
Afterwards, hence it is evident that improve, the object that swells disappears, no rectal tenesmus sense.
It is pungent certain, 25 years old, female, podex cusalgia, it is wet itch, anus pleat has a small amount of secretion.Use drug of the present invention 10 days
Afterwards, hence it is evident that improve, pain and it is wet itch substantially reduced, anus pleat restores, pain and wet itch disappear completely without secretion after 20 days
It loses.
Slowly certain, 26 years old, female, the swollen object of the paranal protuberance of toposcopy had tenderness, sometimes can be with general malaise and fever.
Restored completely after 20 days using drug of the present invention, swell swollen object and disappear, no tenderness, sense of discomfort disappears.
Poplar, 26 years old, female, podex cusalgia, it is wet itch, anus pleat has a small amount of secretion.Use drug of the present invention 10 days
Afterwards, hence it is evident that improve, pain and it is wet itch substantially reduced, anus pleat restores, pain and wet itch disappear completely without secretion after 20 days
It loses.
Mr. Wang, female, 58 years old, the swollen object of the paranal protuberance of toposcopy had tenderness, sometimes can be with general malaise and fever.
Restored completely after 20 days using drug of the present invention, swell swollen object and disappear, no tenderness, sense of discomfort disappears.
Experimental example 2：Performance study
1 research project：Drug of the present invention is made by embodiment 1.
2 viscosities are tested.
Hold the measure of viscous force by《Chinese Pharmacopoeia》2010 editions Ⅹ II E emplastrums of an annex stick amylograph（Second
Method holds the measure of viscous force）It measures, the results are shown in Table 3；
Peel strength is pressed《Chinese Pharmacopoeia》2010 editions Ⅹ II E emplastrums of an annex stick amylograph（The stripping of third method is strong
The measure of degree）It measures, the results are shown in Table 3.
Conclusion：Drug viscosity of the present invention meets the requirements, and stickiness is moderate, and lotion plasticity is preferable, and affinity is strong, to skin
Irritation is small.
3 skin irritation tests.
Please 20 professionals carry out it is blank feel scoring, hundred-mark system takes geometrical mean.It the results are shown in Table 4.
Scoring such as table 5：
As seen from table, pharmaceutical properties of the present invention are good.
Compared with prior art, the present invention has the effect of cooling blood and hemostasis, swelling and pain relieving.Available for treatment piles, outside
Hemorrhoid and anal inflammation etc..Medicine patch plasticity is good made of medicinal plaster stroma of the present invention, without pullling dermal sensation, and hold when movable
It is easily peelable, painless, skin situation without exception after stripping.Drug extract of the present invention coordinates medicinal plaster stroma of the present invention to be made
Patch, not only with cooling blood and hemostasis, the effect of swelling and pain relieving, also have the characteristics that work rapid, eutherapeutic.
Invention is further described, but be not intended as the foundation limited the present invention with reference to embodiment.
Specific embodiment：
Embodiment 1
Patch formula：Liu Jisheng 400g, charred RADIX SANGUISORBAE 400g, calcined gypsum 300g, saltcake 150g, borneol 50g, sorbierite 70g, glycerine
80g, stearic acid 80g, tristearin 70g, yellow petroleum jelly 30g, sucrose stearate 10g, lanolin 20g, polyoxyethylene sorbitan monoleate g, benzene first
Sour 6g and ethyl hydroxy benzoate 1.5g.
Technique：Include the following steps：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake, add water to cook it is secondary, for the first time plus 8 times amount water, decoct 2 hours, second
Secondary plus 6 times of amount water, decoct 1.5 hours, collecting decoction, relative density is 1.05 when filtrate adds in borneol and is concentrated into 78-82 DEG C
~1.15 medicinal extract obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 15 minutes, 78-82 DEG C keeps the temperature 30 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress, be made 1000 patches to get.
Usage and dosage：External application is affixed on affected part, changes within 1 day primary.
Embodiment 2
Patch formula：Liu Jisheng 420g, charred RADIX SANGUISORBAE 420g, calcined gypsum 320g, saltcake 170g, borneol 55g, sorbierite 75g, glycerine
85g, stearic acid 85g, tristearin 75g, yellow petroleum jelly 35g, sucrose stearate 12g, lanolin 22g, polysorbate 85 g, benzene first
Sour 7g and ethyl hydroxy benzoate 1.8g.
Technique：Include the following steps：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake, add water to cook secondary, for the first time plus 9 times of amount water, decoct 2.5 hours, and the
Secondary plus 7 times of amount water, decoct 2 hours, collecting decoction, filtration, relative density is when filtrate adds in borneol and is concentrated into 78-82 DEG C
1.05~1.15 medicinal extract obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 20 minutes, 78-82 DEG C keeps the temperature 35 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress, be made 1000 patches to get.
Usage and dosage：External application is affixed on affected part, changes within 1 day primary.
Embodiment 3
Paste ingredient：Liu Jisheng 380g, charred RADIX SANGUISORBAE 380g, calcined gypsum 280g, saltcake 130g, borneol 45gg.
Technique：Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake and borneol add water to cook secondary, first time plus 7 times of amount water, pan-fried
It boils 1.5 hours, second plus 5 times of amount water, decocts 1 hour, collecting decoction, filtration, filtrate adds in borneol and is concentrated into 78-82 DEG C
When relative density be 1.05~1.15 medicinal extract to get.
Usage and dosage：External application, is applied to affected part, and each 5-15g is changed once per 4-6h.
Claims (10)
1. a kind of external preparation for treating hemorrhoid, it is characterised in that：The external preparation is calculated in parts by weight, by Liu Jisheng
40-60 parts of 350-450 parts, 350-450 parts of charred RADIX SANGUISORBAE, 250-350 parts of calcined gypsum, 100-200 parts of saltcake and borneol are prepared.
2. the external preparation for the treatment of hemorrhoid as described in claim 1, it is characterised in that：The external preparation is in parts by weight
It calculates, by 380-420 parts of Liu Jisheng, 380-420 parts of charred RADIX SANGUISORBAE, 280-320 parts of calcined gypsum, 130-170 parts of saltcake and borneol 45-55
Part is prepared.
3. the external preparation for the treatment of hemorrhoid as claimed in claim 2, it is characterised in that：The external preparation is in parts by weight
It calculates, is prepared by 50 parts of 400 parts of Liu Jisheng, 400 parts of charred RADIX SANGUISORBAE, 300 parts of calcined gypsum, 150 parts of saltcake and borneol.
4. the external preparation of the treatment hemorrhoid as described in any one of claim 1-3, it is characterised in that：The external preparation is
Patch or paste.
5. the external preparation for the treatment of hemorrhoid as claimed in claim 4, it is characterised in that：When the external preparation is patch,
Matrix is further included, the matrix calculates by weight, by 60-80 parts of sorbierite, 70-90 parts of glycerine, 70-90 parts of stearic acid, hard
60-80 parts of fat, 20-40 parts of yellow petroleum jelly, 5-15 parts of sucrose stearate, 15-25 parts of lanolin, 70-90 parts of polysorbate, benzene
1-2 parts of compositions of 3-9 parts of formic acid and ethyl hydroxy benzoate.
6. the external preparation for the treatment of hemorrhoid as claimed in claim 5, it is characterised in that：The matrix calculates by weight, by
65-75 parts of sorbierite, 75-85 parts of glycerine, 75-85 parts of stearic acid, 65-75 parts of tristearin, 25-35 parts of yellow petroleum jelly, sucrose are stearic
1.2-1.8 parts of 8-12 parts of acid esters, 18-22 parts of lanolin, 75-85 parts of polysorbate, 5-7 parts of benzoic acid and ethyl hydroxy benzoate compositions.
7. the external preparation for the treatment of hemorrhoid as claimed in claim 6, it is characterised in that：The matrix calculates by weight, by
70 parts of sorbierite, 80 parts of glycerine, 80 parts of stearic acid, 70 parts stearic, 30 parts of yellow petroleum jelly, 10 parts of sucrose stearate, lanolin
1.5 parts of 20 parts, polyoxyethylene sorbitan monoleate part, 6 parts of benzoic acid and ethyl hydroxy benzoate form.
8. the external preparation of the treatment hemorrhoid as described in claim 5-7, it is characterised in that：The patch is prepared：Including
Following steps：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum and saltcake, add water to cook secondary, and for the first time plus 7-9 times is measured water, decocts 1.5-2.5
Hour, second plus 5-7 times measure water, decoct 1-2 hour, collecting decoction, filtration, filtrate addition borneol is simultaneously concentrated into 78-82 DEG C
When relative density be 1.05~1.15 medicinal extract, obtain A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifyings 10-20 minute, 78-82 DEG C keeps the temperature 25-35 minute, addition benzoic acid, ethyl hydroxy benzoate, mixed
It is even, it is filling to get.
9. the external preparation for the treatment of hemorrhoid as claimed in claim 8, it is characterised in that：The patch is prepared：Including with
Lower step：
（1）Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum, saltcake, add water to cook it is secondary, for the first time plus 8 times amount water, decoct 2 hours, second
Secondary plus 6 times of amount water, decoct 1.5 hours, collecting decoction, filtration, relative density is when filtrate adds in borneol and is concentrated into 78-82 DEG C
1.05~1.15 medicinal extract obtains A product；
（2）Sorbierite, glycerine are taken, is added in A product, is heated to 78-82 DEG C, makes dissolving, obtain B product；
（3）Separately stearic acid, tristearin, yellow petroleum jelly, poly- sorb fat, lanolin, sucrose stearate is taken to be heated to 78-82 DEG C, made
Melting, obtains C product；
（4）C product and B product mixing and emulsifying 15 minutes, 78-82 DEG C keeps the temperature 30 minutes, adds in benzoic acid, ethyl hydroxy benzoate, and mixing fills
Dress to get.
10. the external preparation for the treatment of hemorrhoid as claimed in claim 4, it is characterised in that：The paste is prepared：
Liu Jisheng, charred RADIX SANGUISORBAE, calcined gypsum and saltcake, add water to cook secondary, and for the first time plus 7-9 times is measured water, and it is small to decoct 1.5-2.5
When, for the second time plus 5-7 times is measured water, is decocted 1-2 hours, collecting decoction, filtration, when filtrate adds in borneol and is concentrated into 78-82 DEG C
Relative density be 1.05~1.15 medicinal extract to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810136788.7A CN108186761A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating hemorrhoid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810136788.7A CN108186761A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating hemorrhoid and preparation method thereof |
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| CN108186761A true CN108186761A (en) | 2018-06-22 |
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ID=62592948
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810136788.7A Pending CN108186761A (en) | 2018-02-09 | 2018-02-09 | A kind of external preparation for treating hemorrhoid and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194943A (en) * | 2007-12-11 | 2008-06-11 | 徐欢欢 | Fumigation medicament for treating anoschisis |
| CN102233039A (en) * | 2011-05-10 | 2011-11-09 | 大连神植康缘科技有限公司 | Traditional Chinese medicine ointment used for treating hemorrhoid |
| CN107137508A (en) * | 2017-05-09 | 2017-09-08 | 王景文 | It is a kind of to treat medicine of hemorrhoid and preparation method thereof |
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2018
- 2018-02-09 CN CN201810136788.7A patent/CN108186761A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194943A (en) * | 2007-12-11 | 2008-06-11 | 徐欢欢 | Fumigation medicament for treating anoschisis |
| CN102233039A (en) * | 2011-05-10 | 2011-11-09 | 大连神植康缘科技有限公司 | Traditional Chinese medicine ointment used for treating hemorrhoid |
| CN107137508A (en) * | 2017-05-09 | 2017-09-08 | 王景文 | It is a kind of to treat medicine of hemorrhoid and preparation method thereof |
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| Title |
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| 彭中；等: "痔炎散外敷治疗痔疮", 《中医外治杂志》 * |
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Application publication date: 20180622 |