CN108096172A - A kind of makeup removing breast and preparation method thereof - Google Patents
A kind of makeup removing breast and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention relates to cosmetic technical fields, and in particular to a kind of makeup removing breast and preparation method thereof.The present invention extracts active ingredient from sunset abelmoschus root, it is led as multiclass substance, thickener and stabilizer can be used as, it is a kind of renewable natural polymer child resource compared with horn of plenty, with degradability, biocompatibility and security, one side water-soluble macromolecule class thickener can improve emulsifiability, have suspending stabilized effect to makeup removing breast, its mobility can be improved and smeared and felt, possess preferable water-retaining property, there is moisturizer；On the other hand, the flavone compound in sunset abelmoschus root in polysaccharide has antibacterial, anti-inflammatory effect, effectively prevents during makeup removing due to unclean the problem of easily blocking pore quick-fried acne of removing ornaments and formal dress, plays skin effect.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of makeup removing breast and preparation method thereof.
Background technology
More and more women can smear various cosmetics on the face now, makeup be almost modern female it is daily must
Standby work, but cosmetics in itself have skin certain injury, and clear water used for cosmetic is difficult to clean out, and remains in face
Cosmetic can block pore, and it is normally metabolic to influence skin, make the normal physiological function of skin hindered and generate each
Kind skin disease, can also accelerate the aging of skin, so every night, the women of makeup must lay down dressing on the face, such as
Fruit makeup removing is not thorough, and cosmetics remain on the face, and meeting blocked pore then easily generates serious consequence.Makeup removal products on the market
Mainly based on makeup remover, makeup removing breast.Makeup remover is mainly using the similar characteristic to mix between grease, oily as solvent,
The color make-up or dirt of face are dissolved, makeup removing effect is efficiently thorough.But it is thick and heavy greasy that it uses skin sense, once cleaning is not in time
Instead can blocked pore, cause the skin problem such as acne, acne.Makeup removing breast is mainly made of water and surfactant, is passed through
The principle of Micellar Solubilization is removed ornaments and formal dress, and quality is salubrious, easy to be easy-to-use, thus is more welcome by young man.
At present, makeup removing breast on the market is mainly using PEG-6 caprylic/caprics glyceride type as makeup removing ingredient, molten adornment speed
Soon, makeup removing effect is good.Although makeup removing effect is outstanding, it is big there are irritation, and dry skin, degreasing power are excessive after makeup removing
Problem.
In summary, the common makeup removing breast of people can only accomplish the residual adornment of removal face at present, but not have while makeup removing
Have skin-protecting function, though can cleaning skin, it is big there are irritation, dry skin, the problem of degreasing power is excessive after makeup removing.
Therefore, we it is necessary to again prepare a kind of new makeup removing breast, solved nowadays in the market with this
The problems of makeup removing breast is preferably adapted to the demand of social and required personnel with this, this will be one very intentional
The thing of justice.
The content of the invention
The technical problems to be solved by the invention：It can only accomplish the residual adornment of removal face for current makeup removing breast, but unload
There is no skin-protecting function while adornment, though energy cleaning skin, it is big there are irritation, dry skin, degreasing power mistake after makeup removing
The problem of big, provides a kind of makeup removing breast and preparation method thereof.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of makeup removing breast, according to the mass fraction, including 2 ~ 4 parts of hexadecanols, 3 ~ 5 parts of glycerin monostearates, 5 ~ 7 parts of glycerine, 50 ~
60 parts of water, which is characterized in that further include 10 ~ 15 parts of emulsifiers, 8 ~ 13 parts of thickeners, 12 ~ 15 parts of massage agents.
The preparation method of the emulsifier includes the following steps：
（1）Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohol, in 35 ~ 40 DEG C of 30 ~ 40min of refluxing extraction, repeat reflux and carry
It takes process 2 ~ 3 times, merges extracting solution, filtering takes filtrate rotary evaporation, and rotary evaporation object A, vacuum distillation removal are cleaned with acetone
Acetone, vacuum drying 18 ~ for 24 hours, obtain dried extract；
（2）According to the mass fraction, 1 ~ 2 part of dried extract, 2 ~ 3 parts of anhydrous CaCl are taken2, 10 ~ 15 portions of Tris-HCl buffer solutions,
0.1 ~ 0.2 part of phospholipase A2, in 35 ~ 38 DEG C of 7 ~ 8h of back flow reaction, production object is obtained, takes production object vacuum distillation, it is true in 0.08MPa
Sky dry 18 ~ for 24 hours, obtain dried object；
（3）According to the mass fraction, 18 ~ 25 parts of dried objects, 3 ~ 6 parts of cholesterol, 2 ~ 3 parts of V are takenEAcetate, 10 ~ 12 parts of camellia oils,
18 ~ 20 parts of chloroform mixing, stir 15 ~ 20min, rotary evaporation obtains rotary evaporation object B, by vitamin C in mass ratio 1：10 dissolvings
Mixed solution is made into PBS buffer solution, by mixed solution in mass ratio 5：3 add in into rotary evaporation object B ultrasonic emulsification 10 ~
15min stands 1 ~ 2h, obtains emulsifier.
The thickener is to take sunset abelmoschus root in mass ratio 1：12 add in purified waters, in 80 ~ 90 DEG C, ultrasonic extraction 15 ~
20min filters, takes filtrate in mass ratio 1：4 add in absolute ethyl alcohol mixing, and 12 ~ 15min is stood in 4 DEG C, and centrifugation takes precipitation dry
It is dry, extract is obtained, takes chloroform: n-butanol in mass ratio 4：1 mixing, adds the extract of chloroform quality 10 ~ 20%, and stirring is mixed
25 ~ 30 min are closed, 4500r/min centrifuges 10 min, and repeated centrifugation 4 ~ 5 times collects supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains
Thickener.
The massage agent is that shell is taken to clean, in mass ratio 1：8, which add in the sodium hydroxide solution that mass fraction is 8%, impregnates
18 ~ for 24 hours, taking-up is cleaned with distilled water, in 95 ~ 100 DEG C of dry 1 ~ 2h, crushed 100 mesh sieves, sieving particle is collected, by quality
Number meter takes 20 ~ 25 parts of sieving particles, 100 parts of water, 8 ~ 10 parts of dispersants, 5040,5 ~ 8 parts of odium stearate, in 90 ~ 95 DEG C of stirrings
2h is mixed, mixture is obtained, takes mixture in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains
Massage agent.
Compared with other methods, advantageous effects are the present invention：
（1）Soybean lecithin of the present invention prepares a kind of liposome, can coated water-soluble cosmetic functional ingredient and package oil
Dissolubility functional component, while unstable, water soluble cosmetics functional component vitamin C is wrapped up with liposome, can be with
The time that vitamin C plays a role is greatlyd improve, whitening, anti-oxidant, damage of the reduction free radical to skin can be reached, from
And reduce wrinkle and improve skin texture, while inhibit the deposition of abnormal pigment and the activity of tyrosinase on skin, and have
Help the reduction of dopachrome, so as to reduce the formation of melanin, synthesize collagen, the effect of cosmetology when reaching makeup removing
Fruit adds in vegetative grease camellia oil, on the one hand pure natural, does not have irritation to skin, is dissolved by the cooperation with liposome
On the other hand cosmetics grease can wrap up wherein oxidizable rotten ingredient, makeup removing effect is more preferably；
（2）The present invention extracts active ingredient from sunset abelmoschus root, and master is multiclass substance, can be used as thickener and stabilizer, be
A kind of renewable natural polymer child resource compared with horn of plenty has degradability, biocompatibility and security, one side water
Insoluble macromolecular class thickener can improve emulsifiability, have suspending stabilized effect to makeup removing breast, can improve its mobility
Feel with smearing, possess preferable water-retaining property, there is moisturizer；On the other hand, the flavonoid in sunset abelmoschus root in polysaccharide
Object has antibacterial, anti-inflammatory effect, effectively prevents and does not block asking for the quick-fried acne of pore easily totally due to removing ornaments and formal dress during removing ornaments and formal dress
Topic, plays skin effect；
（3）The present invention prepares oyster shell whiting using raw oyster shell is discarded, and is modified, and utilization is wet-process modified, reduces surface energy, can
Formed soft-agglomerated, weaker with reference to power, grinding can make it scattered, on the one hand the Ca using carboxyl in calcium carbonate serosity2+、CaOH+、CaHCO3+Etc. component reactions generation precipitation, be covered in shell particles surface, lipophile become by hydrophily, is preferably scattered in
In makeup removing breast system, facial skin can be massaged in makeup removing breast by the other hand adding in oyster shell whiting coarse grain, exfoliating, more
Dirt and grease are effectively removed, makes face smooth.
Specific embodiment
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohols, in 35 ~ 40 DEG C of 30 ~ 40min of refluxing extraction,
It repeats reflux extraction process 2 ~ 3 times, merges extracting solution, filtering takes filtrate rotary evaporation, rotary evaporation object is cleaned with acetone
A, vacuum distillation removal acetone, vacuum drying 18 ~ for 24 hours, dried extract is obtained, according to the mass fraction, takes 1 ~ 2 part of dry extraction
Object, 2 ~ 3 parts of anhydrous CaCl2, 10 ~ 15 parts of Tris-HCl buffer solutions, 0.1 ~ 0.2 part of phospholipase A2, in 35 ~ 38 DEG C of back flow reactions 7 ~
8h obtains production object, take production object vacuum distillation, in 0.08MPa be dried in vacuo 18 ~ for 24 hours, obtain dried object, according to the mass fraction, take
18 ~ 25 parts of dried objects, 3 ~ 6 parts of cholesterol, 2 ~ 3 parts of VEAcetate, 10 ~ 12 parts of camellia oils, 18 ~ 20 parts of chloroform mixing, stirring 15 ~
20min, rotary evaporation obtain rotary evaporation object B, by vitamin C in mass ratio 1：10 be dissolved in PBS buffer solution be made mixing it is molten
Liquid, by mixed solution in mass ratio 5：3 add in 10 ~ 15min of ultrasonic emulsification into rotary evaporation object B, stand 1 ~ 2h, must emulsify
Agent.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 80 ~ 90 DEG C, 15 ~ 20min of ultrasonic extraction, take out
Filter, takes filtrate in mass ratio 1：4 add in absolute ethyl alcohol mixing, and 12 ~ 15min is stood in 4 DEG C, and centrifugation takes precipitation drying, must extract
Object takes chloroform, n-butanol in mass ratio 4：1 mixing, adds the extract of chloroform quality 10 ~ 20%, is stirred 25 ~ 30
Min, 4500r/min centrifuge 10 min, and repeated centrifugation 4 ~ 5 times collects supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
Massage agent：Shell is taken to clean, in mass ratio 1：The sodium hydroxide solution immersion 18 that 8 addition mass fractions are 8% ~
For 24 hours, taking-up is cleaned with distilled water, in 95 ~ 100 DEG C of dry 1 ~ 2h, crushed 100 mesh sieves, sieving particle is collected, by mass fraction
Meter takes 20 ~ 25 parts of sieving particles, 100 parts of water, 8 ~ 10 parts of dispersants, 5040,5 ~ 8 parts of odium stearate, is stirred in 90 ~ 95 DEG C
2h obtains mixture, takes mixture in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, must massage
Agent.
A kind of makeup removing breast according to the mass fraction, takes 10 ~ 15 parts of emulsifiers, 8 ~ 13 parts of thickeners, 12 ~ 15 parts of massage agents, 2 ~
4 parts of hexadecanols, 3 ~ 5 parts of glycerin monostearates, 5 ~ 7 parts of glycerine, 50 ~ 60 parts of water stir 30 ~ 40min in 50 ~ 60 DEG C, must unload
Adornment breast.
Embodiment 1
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohols, in 35 DEG C of refluxing extraction 300min,
It repeating reflux extraction process 2 times, merges extracting solution, filtering takes filtrate rotary evaporation, rotary evaporation object A is cleaned with acetone,
Vacuum distillation removal acetone, is dried in vacuo 18h, obtains dried extract, according to the mass fraction, take 1 part of dried extract, 2 parts of nothings
Water CaCl2, 10 parts of Tris-HCl buffer solutions, 0.1 part of phospholipase A2, in 35 DEG C of back flow reaction 7h, production object is obtained, production object is taken to subtract
Pressure distillation, in 0.08MPa be dried in vacuo 18h, obtain dried object, according to the mass fraction, take 18 parts of dried objects, 3 parts of cholesterol, 2 parts
VEAcetate, 10 parts of camellia oils, 18 parts of chloroform mixing, stir 15min, rotary evaporation obtains rotary evaporation object B, vitamin C is pressed
Mass ratio 1：10 are dissolved in PBS buffer solution mixed solution are made, by mixed solution in mass ratio 5：3 add in rotary evaporation object
Ultrasonic emulsification 10min in B stands 1h, obtains emulsifier.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 80 DEG C, ultrasonic extraction 15min, filter, take filter
Liquid in mass ratio 1：4 add in absolute ethyl alcohols mixing, in 4 DEG C stand 12min, centrifugation, take precipitation drying, obtain extract, take chloroform,
N-butanol in mass ratio 4：1 mixing adds the extract of chloroform quality 10%, is stirred 25 min, 4500r/min centrifugations
10 min, repeated centrifugation 4 times, collect supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
Massage agent：Shell is taken to clean, in mass ratio 1：8, which add in the sodium hydroxide solution that mass fraction is 8%, impregnates 18h, takes
Go out and cleaned with distilled water, in 95 DEG C of dry 1h, crushed 100 mesh sieves, collect sieving particle, according to the mass fraction, take 20 parts of mistakes
Sieve particle, 100 parts of water, 8 parts of dispersants, 5040,5 parts of odium stearate, be stirred 2h in 90 DEG C, obtain mixture, take mixture by
Mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
A kind of makeup removing breast according to the mass fraction, takes 10 parts of emulsifiers, 8 parts of thickeners, 12 parts of massage agents, 2 parts of hexadecanols, and 3
Part glycerin monostearate, 5 parts of glycerine, 50 parts of water stir 30min in 50 DEG C, obtain makeup removing breast.
Embodiment 2
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohols, in 37 DEG C of refluxing extraction 35min,
It repeating reflux extraction process 2 times, merges extracting solution, filtering takes filtrate rotary evaporation, rotary evaporation object A is cleaned with acetone,
Vacuum distillation removal acetone, be dried in vacuo 22h, obtain dried extract, according to the mass fraction, take 1 part of dried extract, 2 ~ 32 parts
Anhydrous CaCl2, 12 parts of Tris-HCl buffer solutions, 0.1 part of phospholipase A2, in 36 DEG C of back flow reaction 7h, production object is obtained, takes production object
Vacuum distillation is dried in vacuo 20h in 0.08MPa, obtains dried object, according to the mass fraction, take 20 parts of dried objects, 5 parts of cholesterol, 2
Part VEAcetate, 11 parts of camellia oils, 19 parts of chloroform mixing, stir 17min, rotary evaporation obtains rotary evaporation object B, by vitamin C
In mass ratio 1：10 are dissolved in PBS buffer solution mixed solution are made, by mixed solution in mass ratio 5：3 add in rotary evaporation
Ultrasonic emulsification 12min in object B stands 1h, obtains emulsifier.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 85 DEG C, ultrasonic extraction 17min, filter, take filter
Liquid in mass ratio 1：4 add in absolute ethyl alcohols mixing, in 4 DEG C stand 13min, centrifugation, take precipitation drying, obtain extract, take chloroform,
N-butanol in mass ratio 4：1 mixing adds the extract of chloroform quality 18%, is stirred 27 min, 4500r/min centrifugations
10 min, repeated centrifugation 5 times, collect supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
Massage agent：Shell is taken to clean, in mass ratio 1：The sodium hydroxide solution immersion 18 that 8 addition mass fractions are 8% ~
For 24 hours, taking-up is cleaned with distilled water, in 97 DEG C of dry 1h, crushed 100 mesh sieves, is collected sieving particle, according to the mass fraction, is taken
27 parts of sieving particles, 100 parts of water, 9 parts of dispersants, 5040,6 parts of odium stearate, are stirred 2h in 94 DEG C, obtain mixture, take mixed
Close object in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
A kind of makeup removing breast according to the mass fraction, takes 12 parts of emulsifiers, 10 parts of thickeners, 13 parts of massage agents, 3 parts of hexadecanols,
4 parts of glycerin monostearates, 6 parts of glycerine, 55 parts of water stir 35min in 55 DEG C, obtain makeup removing breast.
Embodiment 3
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohol, in 40 DEG C of refluxing extraction 40min, repeat to flow back
Extraction process 3 times merges extracting solution, and filtering takes filtrate rotary evaporation, and rotary evaporation object A, vacuum distillation removal are cleaned with acetone
Acetone, vacuum drying for 24 hours, obtain dried extract, according to the mass fraction, take 2 parts of dried extracts, 3 parts of anhydrous CaCl2, 15 parts
Tris-HCl buffer solutions, 0.2 part of phospholipase A2, in 38 DEG C of back flow reaction 8h, production object is obtained, takes production object vacuum distillation, in
0.08MPa is dried in vacuo for 24 hours, is obtained dried object, according to the mass fraction, is taken 25 parts of dried objects, 6 parts of cholesterol, 3 parts of VEAcetate,
12 parts of camellia oils, 20 parts of chloroform mixing, stir 20min, rotary evaporation obtains rotary evaporation object B, by vitamin C in mass ratio 1：
10 are dissolved in PBS buffer solution mixed solution are made, by mixed solution in mass ratio 5：3 add in into rotary evaporation object B ultrasound
15min is emulsified, 2h is stood, obtains emulsifier.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 90 DEG C, ultrasonic extraction 20min, filter, take filter
Liquid in mass ratio 1：4 add in absolute ethyl alcohols mixing, in 4 DEG C stand 15min, centrifugation, take precipitation drying, obtain extract, take chloroform,
N-butanol in mass ratio 4：1 mixing adds the extract of chloroform quality 20%, is stirred 30 min, 4500r/min centrifugations
10 min, repeated centrifugation 5 times, collect supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
Massage agent：Shell is taken to clean, in mass ratio 1：The sodium hydroxide solution immersion 18 that 8 addition mass fractions are 8% ~
For 24 hours, taking-up is cleaned with distilled water, in 100 DEG C of dry 2h, crushed 100 mesh sieves, is collected sieving particle, according to the mass fraction, is taken
25 parts of sieving particles, 100 parts of water, 10 parts of dispersants, 5040,8 parts of odium stearate, are stirred 2h in 95 DEG C, obtain mixture, take
Mixture in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
A kind of makeup removing breast according to the mass fraction, takes 15 parts of emulsifiers, 13 parts of thickeners, 15 parts of massage agents, 4 parts of hexadecanols,
5 parts of glycerin monostearates, 7 parts of glycerine, 60 parts of water stir 40min in 60 DEG C, obtain makeup removing breast.
Comparative example 1
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 90 DEG C, ultrasonic extraction 20min, filter, take filter
Liquid in mass ratio 1：4 add in absolute ethyl alcohols mixing, in 4 DEG C stand 15min, centrifugation, take precipitation drying, obtain extract, take chloroform,
N-butanol in mass ratio 4：1 mixing adds the extract of chloroform quality 20%, is stirred 30 min, 4500r/min centrifugations
10 min, repeated centrifugation 5 times, collect supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
Massage agent：Shell is taken to clean, in mass ratio 1：The sodium hydroxide solution immersion 18 that 8 addition mass fractions are 8% ~
For 24 hours, taking-up is cleaned with distilled water, in 100 DEG C of dry 2h, crushed 100 mesh sieves, is collected sieving particle, according to the mass fraction, is taken
25 parts of sieving particles, 100 parts of water, 10 parts of dispersants, 5040,8 parts of odium stearate, are stirred 2h in 95 DEG C, obtain mixture, take
Mixture in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
A kind of makeup removing breast according to the mass fraction, takes 13 parts of thickeners, 15 parts of massage agents, 4 parts of hexadecanols, 5 parts of monostearates
Glyceride, 7 parts of glycerine, 60 parts of water stir 40min in 60 DEG C, obtain makeup removing breast.
Comparative example 2
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohol, in 40 DEG C of refluxing extraction 40min, repeat to flow back
Extraction process 3 times merges extracting solution, and filtering takes filtrate rotary evaporation, and rotary evaporation object A, vacuum distillation removal are cleaned with acetone
Acetone, vacuum drying for 24 hours, obtain dried extract, according to the mass fraction, take 2 parts of dried extracts, 3 parts of anhydrous CaCl2, 15 parts
Tris-HCl buffer solutions, 0.2 part of phospholipase A2, in 38 DEG C of back flow reaction 8h, production object is obtained, takes production object vacuum distillation, in
0.08MPa is dried in vacuo for 24 hours, is obtained dried object, according to the mass fraction, is taken 25 parts of dried objects, 6 parts of cholesterol, 3 parts of VEAcetate,
12 parts of camellia oils, 20 parts of chloroform mixing, stir 20min, rotary evaporation obtains rotary evaporation object B, by vitamin C in mass ratio 1：
10 are dissolved in PBS buffer solution mixed solution are made, by mixed solution in mass ratio 5：3 add in into rotary evaporation object B ultrasound
15min is emulsified, 2h is stood, obtains emulsifier.
Massage agent：Shell is taken to clean, in mass ratio 1：The sodium hydroxide solution immersion 18 that 8 addition mass fractions are 8% ~
For 24 hours, taking-up is cleaned with distilled water, in 100 DEG C of dry 2h, crushed 100 mesh sieves, is collected sieving particle, according to the mass fraction, is taken
25 parts of sieving particles, 100 parts of water, 10 parts of dispersants, 5040,8 parts of odium stearate, are stirred 2h in 95 DEG C, obtain mixture, take
Mixture in mass ratio 1：9, which add in absolute ethyl alcohol, filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
A kind of makeup removing breast according to the mass fraction, takes 15 parts of emulsifiers, 15 parts of massage agents, 4 parts of hexadecanols, 5 parts of monostearates
Glyceride, 7 parts of glycerine, 60 parts of water stir 40min in 60 DEG C, obtain makeup removing breast.
Comparative example 3
Each phospholipase A2：It is purchased from novozymes (Novi's letter) company.
Shell：It is derived from seafood market and discards raw oyster shell；Dispersant 5040：It is purchased from Guangzhou De Song Chemical Co., Ltd.s.
Emulsifier：Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohol, in 40 DEG C of refluxing extraction 40min, repeat to flow back
Extraction process 3 times merges extracting solution, and filtering takes filtrate rotary evaporation, and rotary evaporation object A, vacuum distillation removal are cleaned with acetone
Acetone, vacuum drying for 24 hours, obtain dried extract, according to the mass fraction, take 2 parts of dried extracts, 3 parts of anhydrous CaCl2, 15 parts
Tris-HCl buffer solutions, 0.2 part of phospholipase A2, in 38 DEG C of back flow reaction 8h, production object is obtained, takes production object vacuum distillation, in
0.08MPa is dried in vacuo for 24 hours, is obtained dried object, according to the mass fraction, is taken 25 parts of dried objects, 6 parts of cholesterol, 3 parts of VEAcetate,
12 parts of camellia oils, 20 parts of chloroform mixing, stir 20min, rotary evaporation obtains rotary evaporation object B, by vitamin C in mass ratio 1：
10 are dissolved in PBS buffer solution mixed solution are made, by mixed solution in mass ratio 5：3 add in into rotary evaporation object B ultrasound
15min is emulsified, 2h is stood, obtains emulsifier.
Thickener：Take sunset abelmoschus root in mass ratio 1：12 add in purified water, in 90 DEG C, ultrasonic extraction 20min, filter, take filter
Liquid in mass ratio 1：4 add in absolute ethyl alcohols mixing, in 4 DEG C stand 15min, centrifugation, take precipitation drying, obtain extract, take chloroform,
N-butanol in mass ratio 4：1 mixing adds the extract of chloroform quality 20%, is stirred 30 min, 4500r/min centrifugations
10 min, repeated centrifugation 5 times, collect supernatant, and rotary evaporation is concentrated under reduced pressure, and obtains thickener.
A kind of makeup removing breast according to the mass fraction, takes 15 parts of emulsifiers, 13 parts of thickeners, 4 parts of hexadecanols, 5 parts of monostearates
Glyceride, 7 parts of glycerine, 60 parts of water stir 40min in 60 DEG C, obtain makeup removing breast.
Comparative example 4：The makeup breast of Guangzhou cosmetics Co., Ltd production
Method：280 adult females are chosen as experimenter, makes up for it and is classified as 4 groups, respectively using embodiment and comparison
Makeup removing breast prepared by example after makeup removing, records the use feedback of tester.
The specific detection case of makeup removing breast such as table 1
Table 1
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Makeup removing effect is fine | 30 | 34 | 38 | 17 | 19 | 16 | 13 |
| Makeup removing effect is general | 6 | 4 | 2 | 17 | 10 | 12 | 17 |
| Makeup removing effect is bad | 4 | 2 | 0 | 6 | 11 | 12 | 10 |
Safety testing：The makeup removing breast that embodiment is produced with comparative example is chosen, chooses four matter yellowish-brown adult guinea pigs, in its back of the body
Portion both sides shaving goes to hair-fields into several.Swab stick used for cosmetic is coated with successively daily, its security is detected after experiment.
Makeup removing breast safety detection situation such as table 2
Table 2
From the foregoing, it will be observed that the makeup removing breast makeup removing effect that the present invention is produced is good, between each component there is synergistic effect, can effectively carry
The effect of high makeup removing breast, and production method is simple to operation, security and stability is high, is worthy to be popularized and uses.
Claims (4)
1. a kind of makeup removing breast, according to the mass fraction, including 2 ~ 4 parts of hexadecanols, 3 ~ 5 parts of glycerin monostearates, 5 ~ 7 parts of glycerine,
50 ~ 60 parts of water, which is characterized in that further include 10 ~ 15 parts of emulsifiers, 8 ~ 13 parts of thickeners, 12 ~ 15 parts of massage agents.
2. makeup removing breast according to claim 1, which is characterized in that the preparation method of the emulsifier includes the following steps：
（1）Take soybean lecithin in mass ratio 1：9 add in absolute ethyl alcohol, in 35 ~ 40 DEG C of 30 ~ 40min of refluxing extraction, repeat reflux and carry
It takes process 2 ~ 3 times, merges extracting solution, filtering takes filtrate rotary evaporation, and rotary evaporation object A, vacuum distillation removal are cleaned with acetone
Acetone, vacuum drying 18 ~ for 24 hours, obtain dried extract；
According to the mass fraction, 1 ~ 2 part of dried extract, 2 ~ 3 parts of anhydrous CaCl are taken2, 10 ~ 15 portions of Tris-HCl buffer solutions, 0.1 ~
0.2 part of phospholipase A2, in 35 ~ 38 DEG C of 7 ~ 8h of back flow reaction, production object is obtained, production object vacuum distillation is taken, is done in 0.08MPa vacuum
Dry 18 ~ for 24 hours, obtain dried object；
According to the mass fraction, 18 ~ 25 parts of dried objects, 3 ~ 6 parts of cholesterol, 2 ~ 3 parts of V are takenEAcetate, 10 ~ 12 parts of camellia oils, 18 ~ 20
Part chloroform mixing, stirs 15 ~ 20min, rotary evaporation obtains rotary evaporation object B, by vitamin C in mass ratio 1：10 are dissolved to PBS
Mixed solution is made in buffer solution, by mixed solution in mass ratio 5：3 add in into rotary evaporation object B ultrasonic emulsification 10 ~
15min stands 1 ~ 2h, obtains emulsifier.
3. makeup removing breast according to claim 1, which is characterized in that the thickener is to take sunset abelmoschus root in mass ratio 1：12 add in
Purified water in 80 ~ 90 DEG C, 15 ~ 20min of ultrasonic extraction, filters, takes filtrate in mass ratio 1：4 add in absolute ethyl alcohol mixing, in 4
DEG C stand 12 ~ 15min, centrifugation, take precipitation drying, obtain extract, take chloroform, n-butanol in mass ratio 4：1 mixing, adds chlorine
The extract of imitative quality 10 ~ 20% is stirred 25 ~ 30 min, and 4500r/min centrifuges 10 min, and repeated centrifugation 4 ~ 5 times is collected
Supernatant, rotary evaporation are concentrated under reduced pressure, and obtain thickener.
4. makeup removing breast according to claim 1, which is characterized in that the massage agent is that shell is taken to clean, in mass ratio 1：8 add
Enter mass fraction be 8% sodium hydroxide solution impregnate 18 ~ for 24 hours, taking-up is cleaned with distilled water, in 95 ~ 100 DEG C of dry 1 ~ 2h, powder
Broken 100 mesh sieve of mistake collects sieving particle, according to the mass fraction, takes 20 ~ 25 parts of sieving particles, 100 parts of water, 8 ~ 10 parts of dispersants
5040th, 5 ~ 8 parts of odium stearate are stirred 2h in 90 ~ 95 DEG C, obtain mixture, take mixture in mass ratio 1：9 add in anhydrous second
Alcohol filters, and takes filtrate rotary evaporation, dry, obtains massage agent.
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| CN201711491734.4A CN108096172A (en) | 2017-12-30 | 2017-12-30 | A kind of makeup removing breast and preparation method thereof |
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| WO2017090811A1 (en) * | 2015-11-23 | 2017-06-01 | 정한수 | Soap for make-up removal containing plant component extracts and method for manufacturing same |
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|---|---|---|---|---|
| CN104706561A (en) * | 2013-12-17 | 2015-06-17 | 兰赫(上海)生物科技有限公司 | Face cleansing cream |
| WO2017090811A1 (en) * | 2015-11-23 | 2017-06-01 | 정한수 | Soap for make-up removal containing plant component extracts and method for manufacturing same |
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