CN108079058A - 含四方蒿的中药组合物及其制备方法 - Google Patents
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Abstract
本发明公开了含四方蒿的中药组合物及其制备方法，原料由以下重量份的中药组分组成：四方蒿20‑50份、荠菜50‑100份、凤尾草10‑30份、金沙藤10‑30份、乌药6‑15份、甘草6‑15份。该中药组合物具有清热解毒、散瘀止痛、消炎、利尿之功效，能有效治疗急、慢性肾炎，具有良好的疗效。
Description
技术领域
本发明属于药品领域，涉及一种含四方蒿的能够起到治疗急、慢性肾炎的中药组合物及其制备方法。
背景技术
肾炎，是一种与感染有关的免疫反应性疾病，临床上分为急性肾炎和慢性肾炎。临床表为乏力、腰部疼痛、纳差、肉眼血尿、水肿、高血压、肾功能异常、尿量减少(部分患者少尿)、充血性心力衰竭等。肾脏的生理功能主要是排泄代谢产物及调节水、电解质和酸碱平衡，维持机体内环境稳定。肾炎是以肾组织结构发生炎性改变为基本特征，引起不同程度肾功能减退的一组肾脏疾病，可由多种病因引起。肾炎是一种免疫性疾病是肾免疫介导的炎性反应，是不同的抗原微生物感染人体后，产生不同的抗体，结合成不同的免疫复合物，沉积在肾脏的不同部位造成的病理损伤，形成不同的肾炎类型。本发明采用清热解毒、散瘀止痛、消炎、利尿的治疗方法，科学组方而成，对肾炎具有普遍针对性。除本发明外尚未见有四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草组合物的报道。
(1)四方蒿，本品为唇形科植物四方蒿Elsholtzia blanda(Benth.)Benth.的干燥全草。【性味】苦辛，凉。【功能主治】清热，消炎，止痛。治肾盂肾炎，肾炎，感冒，肝炎，痢疾，肠炎，牙痛，结合膜炎，创伤出血。
(2)荠菜，本品为十字花科荠菜属植物荠菜Capsella bursa-pastoris(Linn.)Medic.的干燥全草。【性味】甘，平。【功能主治】凉血止血，清热利尿。用于肾结核尿血，产后子宫出血，月经过多，肺结核咯血，高血压病，感冒发热，肾炎水肿，泌尿系结石，乳糜尿，肠炎。
(3)凤尾草，本品为凤尾蕨科植物凤尾草Pteris multifida Poir.的干燥全草。【性味】淡、微苦，凉。【功能主治】清热利湿，解毒止痢，凉血止血。用于痢疾、胃肠炎、肝炎、泌尿系感染、感冒发烧、咽喉肿痛、白带、崩漏、农药中毒；外用治外伤出血，烧烫伤。
(4)金沙藤，本品为海金沙科植物海金沙Lygodium japonicum(Thunb.)Sw.的地上部分。【性味】甘；寒；无毒【归经】小肠；膀胱；肝经【功能主治】清热解毒；利水通淋；活血通络。主热淋；石淋；血淋；小便不利；水肿；白浊；带下；肝炎；泄泻；痢疾；感冒发热；咳喘；咽喉肿痛；口疮；目赤肿痛；痄腮；乳痈；丹毒；带状疱疹；水火烫伤；皮肤瘙痒；跌打伤肿；风湿痹痛；外伤出血。
(5)乌药，本品为樟科植物乌药Lindera aggregata(Sims)Kosterm.的干燥块根。【性味】辛，温。【归经】归肺、脾、肾、膀胱经。【功能主治】顺气止痛，温肾散寒。用于胸腹胀痛，气逆喘急，膀胱虚冷，遗尿尿频，疝气，痛经。
(6)甘草，本品为豆科植物甘草Glycyrrhiz uralensis Fisch.、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza gla-bra L.的干燥报及根茎。【性味与归经】甘，平。归心、肺、脾、胃经。【功能与主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
以上背景技术内容的公开仅用于辅助理解本发明的发明构思及技术方案，其并不必然属于本专利申请的现有技术，在没有明确的证据表明上述内容在本专利申请的申请日已经公开的情况下，上述背景技术不应当用于评价本申请的新颖性和创造性。
发明内容
本发明的目的是提供一种含四方蒿的能够起到治疗急、慢性肾炎的中药组合物及其制备方法。
本发明人通过中医理论的指导，与现代中药先进制剂技术相结合，通过合理配制，制成一种含四方蒿的中药组合物，此中药组合物具有清热解毒、散瘀止痛、消炎、利尿之功效，能有效治疗急、慢性肾炎，达到提高生活质量的目的。
本发明所采用的技术方案如下：
含四方蒿的中药组合物，原料由以下重量份的中药组分组成：四方蒿20-50份、荠菜50-100份、凤尾草10-30份、金沙藤10-30份、乌药6-15份、甘草6-15份。
以上所述的含四方蒿的中药组合物，原料优选由以下重量份的中药组分组成：四方蒿30份、荠菜75份、凤尾草20份、金沙藤20份、乌药10份、甘草10份。
以上所述的含四方蒿的中药组合物，所述中药组合物制备成药学上可接受的任意剂型。所述组合物优选制备成固体制剂。所述固体制剂优选为片剂、胶囊剂。
以上所述含四方蒿的中药组合物制成胶囊剂的制备方法，包括以下步骤：
S1：按重量份分别称取组分：四方蒿20-50份、荠菜50-100份、凤尾草10-30份、金沙藤10-30份、乌药6-15份、甘草6-15份；
S2：将称量好的四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草，加5-10倍量水煎煮提取1-3次，每次1-3小时，滤过，合并滤液，浓缩，加入淀粉，制粒，干燥，得干颗粒；
S3：将上述干颗粒加入辅料，制成胶囊剂。
以上所述含四方蒿的中药组合物制成胶囊剂的制备方法，所述原料优选由以下重量份的中药组分组成：四方蒿30份、荠菜75份、凤尾草20份、金沙藤20份、乌药10份、甘草10份。
以上所述含四方蒿的中药组合物制成胶囊剂的制备方法，所述步骤S2优选提取2次，每次2小时。
以上所述含四方蒿的中药组合物制成胶囊剂的制备方法，所述辅料优选为二氧化硅、硬脂酸镁、微晶纤维素。
以上所述含四方蒿的中药组合物，所述中药组合物在制备治疗急慢性肾炎的应用。
本发明含四方蒿的中药组合物，是在中医药传统理论的基础上，结合民间用药经验，运用现代科学理论配制而成。方中四方蒿，具有清热、消炎、止痛之功，为方中君药；荠菜、凤尾草、金沙藤具有清热、利尿、通络之功，同为臣药；乌药具有理气、止痛之功，为佐药；甘草具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效，为使药；诸药合用共奏清热解毒、散瘀止痛、消炎、利尿之功。本发明组方严谨，药少力专，对急、慢性肾炎具有良好的疗效。
具体实施方式
下面结合具体实施例对本发明作进一步描述，但不限制本发明的保护范围和应用范围：
一、胶囊剂的制备
实施例1
含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份分别称取组分：四方蒿20kg、荠菜50kg、凤尾草10kg、金沙藤10kg、乌药6kg、甘草6kg；
S2：将称量好的四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草，加5倍量水煎煮提取3次，每次1小时，滤过，合并滤液，浓缩，加入淀粉，制粒，干燥，粉碎，得干颗粒；
S3：将上述干颗粒加入二氧化硅、硬脂酸镁、微晶纤维素，混匀，装入胶囊，即得。
实施例2
含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份分别称取组分：四方蒿50kg、荠菜100kg、凤尾草30kg、金沙藤30kg、乌药15kg、甘草15kg；
S2：将称量好的四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草，加10倍量水煎煮提取2次，每次3小时，滤过，合并滤液，浓缩，加入淀粉，制粒，干燥，粉碎，得干颗粒；
S3：将上述干颗粒加入二氧化硅、硬脂酸镁、微晶纤维素，混匀，装入胶囊，即得。
实施例3
含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份分别称取组分：四方蒿30kg、荠菜75kg、凤尾草20kg、金沙藤20kg、乌药10kg、甘草10kg；
S2：将称量好的四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草，加10倍量水煎煮提取3次，每次2小时，滤过，合并滤液，浓缩，加入淀粉，制粒，干燥，粉碎，得干颗粒；
S3：将上述干颗粒加入二氧化硅、硬脂酸镁、微晶纤维素，混匀，装入胶囊，即得。
二、临床应用
本发明含四方蒿的中药组合物，曾用于治疗和观察238例病人或志愿者。将上述制备好的3种实施例样品，分别用于下列2种不同类型的病人或志愿者。A:急性肾炎，以急性发作的血尿、蛋白尿、水肿和高血压，可伴有肾功能下降为主要症状(共117例，男61例，女56例，平均年龄35.2岁)；B:慢性肾炎，以蛋白尿、血尿、水肿、高血压，肾功能不全或贫血为主要症状(共121例，男65例，女56例，平均年龄37.5岁)。每一种实施例样品用于上述两种类型的病例不少于20例。结果：A组：痊愈75例，改善37例，无效5例，有效率95.7％；B组：痊愈62例，改善53例，无效6例，有效率95.0％。结果表明：采用本发明中药组合物制备的各种制剂，使用安全、有效，对急慢性肾炎有良好的疗效，能有效缓解患者的痛苦，达到提高生活质量的目的。以下为2个典型病例：
病例1：黄××，男，35岁，以乏力、腰部疼痛、纳差、水肿、高血压、尿量减少为主要症状，经医院诊断为急性肾炎。服用本发明的中药组合物制成的胶囊剂(实施例1)，每次3粒(0.5g/粒)，每日3次，连服10日，以上症状全部消失，肾功能恢复正常，痊愈。
病例2：秦××，女，24岁，以血尿、乏力、面色苍白，记忆减退为主要症状，经医院检查诊断为慢性肾炎。服用本发明含四方蒿的中药组合物制成的胶囊剂(实施例1)，每次3粒(0.5g/粒)，每日3次，连服30日，以上症状全部消失，痊愈。
病例3：向××，男，44岁，乏力、腰部疼痛、纳差、肉眼血尿、水肿、高血压、肾功能异常、尿量减少、充血性心力衰竭。经医院检查诊断为慢性肾炎。服用本发明含四方蒿的中药组合物制成的胶囊剂(实施例1)，每次3粒(0.5g/粒)，每日3次，连服30日，以上症状全部消失，痊愈。
以上内容是结合具体的/优选的实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，其还可以对这些已描述的实施例做出若干替代或变型，而这些替代或变型方式都应当视为属于本发明的保护范围。
Claims (10)
1.含四方蒿的中药组合物，其特征在于，原料由以下重量份的中药组分组成：四方蒿20-50份、荠菜50-100份、凤尾草10-30份、金沙藤10-30份、乌药6-15份、甘草6-15份。
2.根据权利要求1所述的含四方蒿的中药组合物，其特征在于，原料由以下重量份的中药组分组成：四方蒿30份、荠菜75份、凤尾草20份、金沙藤20份、乌药10份、甘草10份。
3.根据权利要求1所述的含四方蒿的中药组合物，其特征在于，所述中药组合物制备成药学上可接受的任意剂型。
4.根据权利要求1所述的含四方蒿的中药组合物，其特征在于，所述组合物制备成固体制剂。
5.根据权利要求1所述的含四方蒿的中药组合物，其特征在于所述固体制剂为片剂、胶囊剂。
6.一种如权利要求1所述含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份分别称取组分：四方蒿20-50份、荠菜50-100份、凤尾草10-30份、金沙藤10-30份、乌药6-15份、甘草6-15份；
S2：将称量好的四方蒿、荠菜、凤尾草、金沙藤、乌药、甘草，加5-10倍量水煎煮提取1-3次，每次1-3小时，滤过，合并滤液，浓缩，干燥，粉碎，即得干颗粒；
S3：将上述干颗粒加入辅料，制成胶囊剂。
7.根据权利要求6所述含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，所述原料由以下重量份的中药组分组成：四方蒿30份、荠菜75份、凤尾草20份、金沙藤20份、乌药10份、甘草10份。
8.根据权利要求6所述含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，所述步骤S2提取2次，每次2小时。
9.根据权利要求6所述含四方蒿的中药组合物制成胶囊剂的制备方法，其特征在于，所述辅料为二氧化硅、硬脂酸镁、微晶纤维素。
10.如权利要求1所述含四方蒿的中药组合物，其特征在于，所述中药组合物在制备治疗急慢性肾炎的应用。
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