CN108066500A - 一种临床护理上用于治疗烧烫伤的药剂 - Google Patents
一种临床护理上用于治疗烧烫伤的药剂 Download PDFInfo
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Abstract
本发明公开了一种临床护理上用于治疗烧烫伤的药剂，包括以下重量份的原料盐酸林可霉素0.5～1.2份，中药提取物2～6份，赋形剂200～230份，猪油10～18份，所述中药提取物包括以下重量份的原料：青黛5～10份，马齿苋3～8份，忍冬藤6～12份，锦灯笼5～10份，菊花13～18份，厚朴10～15份，大叶桉5～10份，爵床3～8份，山茶花8～13份，三七3～8份，炉甘石粉8～13份，鹿角胶5～15份，白芷3～8份。本发明提出的药剂，由盐酸林可霉素、中药提取物、赋形剂和猪油制备而成，各原料的配比合理，治疗效果显著，适用范围广，治疗周期短，治疗后不易产生疤痕，制备方法简单，中药的提取效率高。
Description
技术领域
本发明涉及药剂研发技术领域，尤其涉及一种临床护理上用于治疗烧烫伤的药剂。
背景技术
烧烫伤是火焰、灼热气体、液体、固体等热力所引起的机体损伤，其是日常生活中最常见的意外伤害，烧烫伤按深度划分一般可分三度，其中一度烧烫伤是只伤及表皮层，受伤的皮肤发红、肿胀，觉得火辣辣地痛，但无水泡出现；二度烧烫伤是伤及真皮层，局部红肿、发热，疼痛难忍，有明显水泡；三度烧烫伤是全层皮肤包括皮肤下面的脂肪、骨和肌肉都受到伤害，皮肤焦黑、坏死。而烧烫伤后的创面如果未能妥善处理，病菌可直接进入血液、淋巴液，引发全身感染，因此烧烫伤创面的处理是治疗烫烧伤的重要环节，直接影响创面的愈合情况。
中国专利授权公告号：CN 103550526B公开了一种临床护理上用于治疗烧烫伤的药剂，该药剂由十六种中药组成，根据实验得出其对于一度和二度烧烫伤具有治疗作用，且一度烧烫伤的治疗周期在5天，二度烧烫伤的治疗周期为10天，而对于三度的烧烫伤并未提及，然而三度烧烫伤对患者的伤害是最大的，也是最容易引起全身感染，以及创面愈合的。基于此，本发明提出一种临床护理上用于治疗一度、二度和三度烧烫伤的药剂。
发明内容
本发明的目的是为了解决现有技术中存在的缺点，而提出的一种临床护理上用于治疗烧烫伤的药剂。
一种临床护理上用于治疗烧烫伤的药剂，包括以下重量份的原料盐酸林可霉素0.5～1.2份，中药提取物2～6份，赋形剂200～230份，猪油10～18份，所述中药提取物包括以下重量份的原料：青黛5～10份，马齿苋3～8份，忍冬藤6～12份，锦灯笼5～10份，菊花13～18份，厚朴10～15份，大叶桉5～10份，爵床3～8份，山茶花8～13份，三七3～8份，炉甘石粉8～13份，鹿角胶5～15份，白芷3～8份。
优选的，所述中药提取物包括以下重量份的原料：青黛58份，马齿苋5份，忍冬藤10份，锦灯笼6份，菊花15份，厚朴12份，大叶桉8份，爵床5份，山茶花10份，三七6份，炉甘石粉10份，鹿角胶12份，白芷5份。
优选的，所述中药提取物包括以下重量份的原料：青黛6份，马齿苋5份，忍冬藤9份，锦灯笼8份，菊花16份，厚朴11份，大叶桉8份，爵床6份，山茶花10份，三七5份，炉甘石粉11份，鹿角胶10份，白芷5份。
优选的，所述盐酸林可霉素和中药提取物的质量比为1：2～8。
本发明还提出了一种临床护理上用于治疗烧烫伤的药剂的制备方法，包括以下步骤：
S1、按照青黛5～10份，马齿苋3～8份，忍冬藤6～12份，锦灯笼5～10份，菊花13～18份，厚朴10～15份，大叶桉5～10份，爵床3～8份，山茶花8～13份，三七3～8份，炉甘石8～13份，鹿角胶5～15份，白芷3～8份称取中药提取物原料，备用；
S2、将步骤S1称取的青黛、马齿苋、忍冬藤、锦灯笼、菊花、厚朴、大叶桉、爵床、山茶花、三七和白芷置于反应瓶中，先用乙醇溶液提取，再用水提取，提取后滤过，收集滤液，加入步骤S1称取的鹿角胶和炉甘石，混合均匀后，减压浓缩回收乙醇至60℃时相对密度为1.15～1.18的膏状物，再将膏状物低温干燥至水分小于2％，然后研磨成粉末，即得中药提取物；
S3、将盐酸林可霉素、中药提取物、赋形剂和猪油按照0.5～1.2：2～6：200～230：10～18的质量比进行取样，并将盐酸林可霉素、中药提取物和猪油于35～40℃下搅拌，待混合均匀后加入赋形剂再混合均匀，即得临床护理上用于治疗烧烫伤的药剂。
优选的，所述乙醇溶液为质量浓度为75％的乙醇水溶液，且乙醇溶液的加入质量为中药提取物总质量的3～5倍、提取的次数为1～2次、提取时间为0.5～1.5h。
优选的，所述水的加入质量为中药提取物总质量的8～10倍、提取的次数为1～2次、提取时间为1～3h。
本发明提出的药剂，由盐酸林可霉素、中药提取物、赋形剂和猪油制备而成，各原料的配比合理，尤其是合理比例的盐酸林可霉素和中药提取物具有协同作用，可以显著提高该药剂的治疗效果，减缓患处的疼痛感，抑制患处病菌的滋生，缩短烧烫伤的治疗时间，对一度、二度和三度烧烫伤均有优异的治疗作用，且创面愈合后不易产生疤痕，使用的中药提取物是从多味中草药中提取的药用成分的混合产物，其对烧烫伤具有一定的治疗效果，再与盐酸林可霉素相配合可以将一度和二度烧烫伤的治疗周期缩短至7天内，且对三度烧烫伤也具有治疗作用，除此之外，本发明还提出了一种操作简单，提取效率高，提取时间短的制备临床护理上用于治疗烧烫伤的药剂的方法。
具体实施方式
下面结合具体实施例对本发明作进一步解说。
实施例一
本发明提出的一种临床护理上用于治疗烧烫伤的药剂，包括以下重量份的原料盐酸林可霉素0.8份，中药提取物4份，赋形剂215份，猪油14份，所述中药提取物包括以下重量份的原料：青黛58份，马齿苋5份，忍冬藤10份，锦灯笼6份，菊花15份，厚朴12份，大叶桉8份，爵床5份，山茶花10份，三七6份，炉甘石粉10份，鹿角胶12份，白芷5份。
其制备方法，包括以下步骤：
S1、按照青黛58份，马齿苋5份，忍冬藤10份，锦灯笼6份，菊花15份，厚朴12份，大叶桉8份，爵床5份，山茶花10份，三七6份，炉甘石粉10份，鹿角胶12份，白芷5份称取中药提取物原料，备用；
S2、将步骤S1称取的青黛、马齿苋、忍冬藤、锦灯笼、菊花、厚朴、大叶桉、爵床、山茶花、三七和白芷置于反应瓶中，先用4倍量的质量浓度为75％的乙醇水溶液提取1h，再用10倍量的水提取2次，每次2h，提取后滤过，收集滤液，加入步骤S1称取的鹿角胶和炉甘石，混合均匀后，减压浓缩回收乙醇至60℃时相对密度为1.15～1.18的膏状物，再将膏状物低温干燥至水分小于2％，然后研磨成粉末，即得中药提取物；
S3、将盐酸林可霉素、中药提取物、赋形剂和猪油按照0.8：4：215：14的质量比进行取样，并将盐酸林可霉素、中药提取物和猪油于35～40℃下搅拌，待混合均匀后加入赋形剂再混合均匀，即得临床护理上用于治疗烧烫伤的药剂。
实施例二
本发明提出的一种临床护理上用于治疗烧烫伤的药剂，包括以下重量份的原料盐酸林可霉素1.2份，中药提取物5份，赋形剂230份，猪油18份，所述中药提取物包括以下重量份的原料：青黛6份，马齿苋4份，忍冬藤10份，锦灯笼10份，菊花15份，厚朴12份，大叶桉8份，爵床4份，山茶花13份，三七3份，炉甘石粉10份，鹿角胶10份，白芷5份。
其制备方法，包括以下步骤：
S1、按照青黛6份，马齿苋4份，忍冬藤10份，锦灯笼10份，菊花15份，厚朴12份，大叶桉8份，爵床4份，山茶花13份，三七3份，炉甘石粉10份，鹿角胶10份，白芷5份称取中药提取物原料，备用；
S2、将步骤S1称取的青黛、马齿苋、忍冬藤、锦灯笼、菊花、厚朴、大叶桉、爵床、山茶花、三七和白芷置于反应瓶中，先用5倍量的质量浓度为75％的乙醇水溶液提取2次，每次0.5h，再用8倍量的水提取3h，提取后滤过，收集滤液，加入步骤S1称取的鹿角胶和炉甘石，混合均匀后，减压浓缩回收乙醇至60℃时相对密度为1.15～1.18的膏状物，再将膏状物低温干燥至水分小于2％，然后研磨成粉末，即得中药提取物；
S3、将盐酸林可霉素、中药提取物、赋形剂和猪油按照1.2：5：230：18的质量比进行取样，并将盐酸林可霉素、中药提取物和猪油于35～40℃下搅拌，待混合均匀后加入赋形剂再混合均匀，即得临床护理上用于治疗烧烫伤的药剂。
对比例一
将实施例一的药剂配方中不加入中药提取物，其他条件同实施例一进行制备。
对比例二
将实施例一的药剂配方中不加入盐酸林可霉素，其他条件同实施例一进行制备。
本发明提出的药剂对烧烫伤治疗效果的实验如下：
1、烧烫伤的判断标准
一度：伤及表皮层，受伤的皮肤发红、肿胀，觉得火辣辣地痛，但无水泡出现；二度：伤及真皮层，局部红肿、发热，疼痛难忍，有明显水泡；三度：全层皮肤包括皮肤下面的脂肪、骨和肌肉都受到伤害，皮肤焦黑、坏死。
2、病例的选择
选取发生烧烫伤的患者164例，年龄10-62岁。其中，男88例，女76例；一度84例，二度64例，三度16例。
将病例均分为4组，每组41人，第1组使用实施例一制备的药剂进行涂抹治疗，第2组使用实施例二制备的药剂进行涂抹治疗，第3组使用对比例一制备的药剂进行涂抹治疗，第4组使用对比例二制备的药剂进行涂抹治疗，7天为一个疗程，治疗7天。
3、疗效评定标准
痊愈：疼痛、红肿、水泡均消失，创面无疤痕；显效：疼痛、红肿、水泡明显好转，创面有轻微疤痕或有新鲜肉芽长出；无效：疼痛、红肿、水泡未见好转，创面疤痕明显。
4、结果
| 痊愈 | 显效 | 无效 | |
| 第1组 | 39 | 2 | 0 |
| 第2组 | 38 | 3 | 0 |
| 第3组 | 16 | 14 | 11 |
| 第4组 | 13 | 21 | 7 |
经过治疗，第1组和第2组的烧烫伤患者90％以上可以在7天内痊愈，剩余的5例显效的患者均为三度烧烫伤，且在继续治疗2个疗程后均达到痊愈标准，而第3组和第4组的患者在7天的治疗结束后仅有32％～39％的患者达到痊愈标准，而三度烧伤患者均在无效队列里，表明：本发明提出的药剂中盐酸林可霉素和中药提取物相互具有协同作用，可以显著提高烧烫伤的治疗效果，尤其是对三度烧烫伤也具有优异的治疗效果，且治疗周期短，一度和二度烧烫伤在7天内均可达到痊愈标准。
5、典型案例
李某某，男，31岁，汽油烧伤，双上肢、背部及面颈分别为三度、二度和二度烧烫伤，使用本发明制备的药剂1个疗程，二度烧烫伤部位痊愈，三度烧烫伤部位为显效，继续使用本发明制备的药剂1个疗程，所有烧烫伤部位均达到痊愈标准。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (7)
1.一种临床护理上用于治疗烧烫伤的药剂，其特征在于，包括以下重量份的原料盐酸林可霉素0.5～1.2份，中药提取物2～6份，赋形剂200～230份，猪油10～18份，所述中药提取物包括以下重量份的原料：青黛5～10份，马齿苋3～8份，忍冬藤6～12份，锦灯笼5～10份，菊花13～18份，厚朴10～15份，大叶桉5～10份，爵床3～8份，山茶花8～13份，三七3～8份，炉甘石粉8～13份，鹿角胶5～15份，白芷3～8份。
2.根据权利要求1所述的一种临床护理上用于治疗烧烫伤的药剂，其特征在于，所述中药提取物包括以下重量份的原料：青黛58份，马齿苋5份，忍冬藤10份，锦灯笼6份，菊花15份，厚朴12份，大叶桉8份，爵床5份，山茶花10份，三七6份，炉甘石粉10份，鹿角胶12份，白芷5份。
3.根据权利要求1所述的一种临床护理上用于治疗烧烫伤的药剂，其特征在于，所述中药提取物包括以下重量份的原料：青黛6份，马齿苋5份，忍冬藤9份，锦灯笼8份，菊花16份，厚朴11份，大叶桉8份，爵床6份，山茶花10份，三七5份，炉甘石粉11份，鹿角胶10份，白芷5份。
4.根据权利要求1所述的一种临床护理上用于治疗烧烫伤的药剂，其特征在于，所述盐酸林可霉素和中药提取物的质量比为1：2～8。
5.根据权利要求1或2或3或4所述的一种临床护理上用于治疗烧烫伤的药剂，其特征在于，其制备方法包括以下步骤：
S1、按照青黛5～10份，马齿苋3～8份，忍冬藤6～12份，锦灯笼5～10份，菊花13～18份，厚朴10～15份，大叶桉5～10份，爵床3～8份，山茶花8～13份，三七3～8份，炉甘石8～13份，鹿角胶5～15份，白芷3～8份称取中药提取物原料，备用；
S2、将步骤S1称取的青黛、马齿苋、忍冬藤、锦灯笼、菊花、厚朴、大叶桉、爵床、山茶花、三七和白芷置于反应瓶中，先用乙醇溶液提取，再用水提取，提取后滤过，收集滤液，加入步骤S1称取的鹿角胶和炉甘石，混合均匀后，减压浓缩回收乙醇至60℃时相对密度为1.15～1.18的膏状物，再将膏状物低温干燥至水分小于2％，然后研磨成粉末，即得中药提取物；
S3、将盐酸林可霉素、中药提取物、赋形剂和猪油按照0.5～1.2：2～6：200～230：10～18的质量比进行取样，并将盐酸林可霉素、中药提取物和猪油于35～40℃下搅拌，待混合均匀后加入赋形剂再混合均匀，即得临床护理上用于治疗烧烫伤的药剂。
6.根据权利要求4所述的一种临床护理上用于治疗烧烫伤的药剂的制备方法，其特征在于，所述乙醇溶液为质量浓度为75％的乙醇水溶液，且乙醇溶液的加入质量为中药提取物总质量的3～5倍、提取的次数为1～2次、提取时间为0.5～1.5h。
7.根据权利要求4所述的一种临床护理上用于治疗烧烫伤的药剂的制备方法，其特征在于，所述水的加入质量为中药提取物总质量的8～10倍、提取的次数为1～2次、提取时间为1～3h。
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Application publication date: 20180525 |