CN108057112A - A kind of middle liquid medicine and dental implant method for oral tooth implantation - Google Patents
A kind of middle liquid medicine and dental implant method for oral tooth implantation Download PDFInfo
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of middle liquid medicine and dental implant method for oral tooth implantation.Middle liquid medicine of the present invention for oral tooth implantation includes following raw material：Honegsukle flower P.E, dandelion extract, sophorae subprostratae radix extract, Rhizoma Curcumae extract, sucrose and water.Middle liquid medicine of the present invention for oral tooth implantation, during tooth-implanting operation, the pain, inflammation and swelling of operative region can effectively be controlled, reduce postoperative infection and swelling, plantation success rate is effectively promoted, while the effect that there is high-effective disinfecting to sterilize, effectively prevent peri-implantitiss, further extend tooth-implanting and remaining natural teeth service life, shorten post-operative recovery time.
Description
Technical field
The invention belongs to oral care techniques fields, and in particular to a kind of for the middle liquid medicine of oral tooth implantation and plant tooth side
Method.
Background technology
Can be counted according to Chinese dentistry, China 45 years old or more middle-aged and elderly people 79% there are agomphosis, particularly 70 years old with
Upper the elderly is much half mouthful or even full mouth missing.The elderly's absence of tooth not only influences normal diet, while adds intestines
Stomach is born, and influences health.
With oral health theory becoming increasingly popular in China, more and more patients start to be concerned about that the tooth of oneself is asked
Topic, the appearance of tooth-implanting technology have well solved worry of many patients for missing tooth.Tooth-implanting be by medicine mode,
By the pure titanium metal high with human body bone compatibility by accurate design, the cylinder or other shapes similar to root of the tooth are manufactured into
Shape is implanted into a manner of surgery minor operation in the alveolar bone of edentulous region, after 1-3 months, when artificial tooth root is close with alveolar bone
After conjunction, then porcelain, full porcelain tooth hat are made on artificial tooth root, since it is not disruptive, tooth-implanting is public by medical circle of oral cavity
Think agomphosis on select repair mode.
However, being given birth to therewith for the new misgivings of tooth-implanting technology, patient often worries pain caused by tooth-implanting operation
Pain, postoperative the problems such as needing the long period that could recover.Traditional tooth-implanting is present with local edema and ecchymosis, general to continue
3-5 days, while peri-implantitiss are tooth-implanting postoperative the problem of patient and doctor is most made to worry.
This invention address that providing a kind of middle liquid medicine for oral tooth implantation, postoperative infection and swelling are reduced, wound is dropped
It is low to minimum degree, ensure that health during tooth-implanting, safety and comfortable.
The content of the invention
The present invention seeks to what is be achieved through the following technical solutions：
During tooth is planted, patient's internal mouth environment is unbalance, particularly pharyngeal sterilizing is difficult and xerostomia etc. because
Element influences, and patient needs to bear swelling and pain, bleeding, chews the pains such as dysphagia.Chinese medicine of the present invention for oral tooth implantation
Water, containing four kinds of honeysuckle, dandelion, subprostrate sophora, curcuma zedoary Chinese medicines, four kinds of medicinal material pharmacological properties, effect organic compatibility, activity increases
By force, there is antimicrobial antiphlogistic.
The first technical problem to be solved by the present invention is to provide a kind of middle liquid medicine for oral tooth implantation.
The middle liquid medicine for oral tooth implantation includes following raw material：Honegsukle flower P.E, dandelion extract, subprostrate sophora
Extract, Rhizoma Curcumae extract, sucrose and water.
Specifically, the middle liquid medicine for oral tooth implantation is prepared by the raw material of following parts by weight：Honeysuckle is extracted
10~20g of object, 10~20g of dandelion extract, 3~7g of sophorae subprostratae radix extract, 5~10g of Rhizoma Curcumae extract, 8~15g of sucrose,
800~1200g of water.
The present invention considers the recovery rate and activity of medicinal material active ingredient during medicinal substances extract is prepared, will
Active ingredient in medicinal material extracts to greatest extent.
In some technical solutions of the present invention, the preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, mistake
40-70 mesh sieves, obtain Honeysuckle Flower；Honeysuckle Flower is weighed, distilled water is added according to 10~12mL/g of liquid ratio, in 80~
When 90 DEG C of extractions 2~4 are small, extracting solution is obtained；After extracting solution is used 200~300 mesh filter-cloth filterings, in 50~55 DEG C, vacuum
When concentration 1~2 is small under conditions of 0.06~0.07MPa of degree, concentrate is obtained；Absolute ethyl alcohol to ethyl alcohol is added in into concentrate to contain
Amount reaches 50~60wt%, is stirred 10~15 minutes with 20~30 revs/min, obtains mixed liquor I；Add then in mixed liquor I
Enter absolute ethyl alcohol to ethanol content and reach 60~70wt%, stirred 10~15 minutes with 20~30 revs/min, obtain mixed liquor
Ⅱ；Continue addition absolute ethyl alcohol to the ethanol content into mixed liquor II and reach 70~80wt%, with 20~30 revs/min of stirrings 10
~15 minutes, obtain mixed liquor III；By mixed liquor III in 5~10 DEG C stand 12~20 it is small when, with 2000~3000 revs/min from
The heart 15~25 minutes collects supernatant liquor；By supernatant liquor vacuum freeze drying, the Honegsukle flower P.E is obtained；It is wherein true
The process conditions of vacuum freecing-dry are：Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, 5~15 DEG C of sublimation temperature, solution
25~30 DEG C, 0.09~0.096MPa of vacuum degree of eutectoid temperature, when vacuum drying time 16~24 is small.
In presently disclosed patent, the most methods using traditional water extract-alcohol precipitation of traditional Chinese medicine extraction, but purifying
Cheng Zhong, alcohol precipitation can cause the loss of active ingredient, so as to influence drug effect.For example, polysaccharide, amino in honeysuckle insoluble in alcohol
Acid is removed, and flavonoids, alkaloid etc. are soluble in the active material of alcohol, and higher recovery rate cannot be obtained by being extracted with water, and
And it is present with the situation for being wrapped and losing when alcohol precipitation.
Therefore, inventor attempts to be purified instead of alcohol precipitation using flocculated method, reduces active ingredient in Chinese medicine
Package improves the content of active material in extract, while extraction efficiency is improved, reduces loss caused by purifying.In addition,
Since flocculant plays an important role of complexation of metal ions, during flocculation is refined, it is possible to reduce heavy metal in liquid from
Son.
In some technical solutions of the present invention, the preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, mistake
40-70 mesh sieves, obtain Honeysuckle Flower；Honeysuckle Flower is weighed, distilled water is added according to 10~12mL/g of liquid ratio, in 80~
When 90 DEG C of extractions 2~4 are small, extracting solution is obtained；After extracting solution is used 200~300 mesh filter-cloth filterings, in 50~55 DEG C, vacuum
When concentration 1~2 is small under conditions of 0.06~0.07MPa of degree, concentrate is obtained；Concentrate weight 0.001 is added in into concentrate
~0.005 times of flocculant, with 20~30 revs/min stirring flocculate 3~4 it is small when after, with 2000~3000 revs/min centrifugation 15
~25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, the Honegsukle flower P.E is obtained；Wherein vacuum is cold
Freezing dry process conditions is：Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, 5~15 DEG C of sublimation temperature, parsing temperature
25~30 DEG C, 0.09~0.096MPa of vacuum degree of degree, when vacuum drying time 16~24 is small.
It is opposite not allow to be also easy to produce precipitation although the stability of liquid that flocculation obtains is relatively good, active ingredient in honeysuckle
Loss also reduce, but flocculate there is also package problem.The analysis found that the active material slant acidity in honeysuckle, such as
Fruit is counted using distilled water as extraction, and active ingredient is not easy to be precipitated.Therefore, inventor attempts the change according to Honegsukle flower P.E
Property is learned, in extraction, according to the dependent interaction principle of electrochemistry, adjusts the pH value of solvent so that the activity of honeysuckle
Ingredient is more prone to be precipitated, and so as to improve extraction efficiency, brings considerable economic benefit.
In some technical solutions of the present invention, the preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, mistake
40-70 mesh sieves, obtain Honeysuckle Flower；Distilled water is adjusted using the sodium bicarbonate aqueous solution of 5~10mmol/L of molar concentration
PH to 8.4~8.5；Honeysuckle Flower is weighed, the distilled water of pH 8.4~8.5 is added according to 10~12mL/g of liquid ratio, in 80
When~90 DEG C of extractions 2~4 are small, extracting solution is obtained；By extracting solution using after 200~300 mesh filter-cloth filterings, in 50~55 DEG C, it is true
When concentration 1~2 is small under conditions of 0.06~0.07MPa of reciprocal of duty cycle, concentrate is obtained；Using the salt of 5~10mmol/L of molar concentration
Acid adjusts the pH to 6.1~6.2 of concentrate, and the flocculant of 0.001~0.005 times of concentrate weight is added in into concentrate, with
After when 20~30 revs/min of stirring flocculations 3~4 are small, centrifuged 15~25 minutes with 2000~3000 revs/min, it is clear to collect upper strata
Liquid；By supernatant liquor vacuum freeze drying, the Honegsukle flower P.E is obtained；The process conditions of wherein vacuum freeze drying are：
Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, 5~15 DEG C of sublimation temperature, 25~30 DEG C of resolution temperature, vacuum degree
0.09~0.096MPa, when vacuum drying time 16~24 is small.
Active ingredient chemical property in dandelion extract is similar with Honegsukle flower P.E, therefore the dandelion is extracted
The preparation method of object may be referred to the preparation method of Honegsukle flower P.E, it is only necessary to which honeysuckle is replaced with dandelion.
In the active ingredient of curcuma zedoary based on curcumin, polysaccharide, sterols, these substances have no meta-acid alkalescence, because
This cannot effectively be extracted curcuma zedoary active ingredient by adjusting the method for solvent acid-base value.Pass through pressurised extraction in the present invention
Mode, increase curcuma zedoary in the diffusion velocity of active ingredient in water, improve the dissolubility of active ingredient, this solves existing skill
In art when extracting curcuma zedoary, the substance that polarity is big and polarity is small is difficult the problem of release simultaneously in extractant.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 40-70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh cowherb
Art powder is placed in pressurised extraction tank, and distilled water, sealing pressing extractor, in extraction are added according to 10~12mL/g of liquid ratio
It is extracted 30~50 minutes under conditions of 0.6~0.7MPa of pressure, 90~100 DEG C of Extracting temperature, obtains extracting solution；Extracting solution is adopted
After 200~300 mesh filter-cloth filterings, when concentration 1~2 is small under conditions of 50~55 DEG C, 0.06~0.07MPa of vacuum degree, obtain
To concentrate；The flocculant of 0.001~0.005 times of concentrate weight is added in into concentrate, is wadded a quilt with cotton with 20~30 revs/min of stirrings
It is solidifying 3~4 it is small when after, centrifuged 15~25 minutes with 2000~3000 revs/min, collect supernatant liquor；Supernatant liquor vacuum is cold
It is lyophilized dry, obtain the Rhizoma Curcumae extract；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, in advance
When the jelly time 1~2 is small, 5~15 DEG C of sublimation temperature, 25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, vacuum drying
When time 16~24 is small.
Main component in subprostrate sophora have alkaloid, polysaccharide and flavonoids these three.With reference to the preparation of Honegsukle flower P.E
Method is improved the preparation method of sophorae subprostratae radix extract.The preparation method of the sophorae subprostratae radix extract is：By subprostrate sophora powder
It is broken, 40-70 mesh sieves are crossed, obtain Vietnamese Sophora Root；The pH to 1 of distilled water is adjusted using the hydrochloric acid of 5~10mmol/L of molar concentration
~2；Weigh Vietnamese Sophora Root, according to 10~12mL/g of liquid ratio add in pH 1~2 distilled water, in 50~60 DEG C extract 12~
16 it is small when, obtain extracting solution；By extracting solution using after 200~300 mesh filter-cloth filterings, in 50~55 DEG C, vacuum degree 0.06~
When concentration 1~2 is small under conditions of 0.07MPa, concentrate is obtained；Sodium acid carbonate using 5~10mmol/L of molar concentration is water-soluble
Liquid adjusts the pH to 9.1~9.2 of concentrate, and the flocculant of 0.001~0.005 times of concentrate weight is added in into concentrate, with
After when 20~30 revs/min of stirring flocculations 3~4 are small, centrifuged 15~25 minutes with 2000~3000 revs/min, it is clear to collect upper strata
Liquid；By supernatant liquor vacuum freeze drying, the sophorae subprostratae radix extract is obtained；The process conditions of wherein vacuum freeze drying are：
Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, 5~15 DEG C of sublimation temperature, 25~30 DEG C of resolution temperature, vacuum degree
0.09~0.096MPa, when vacuum drying time 16~24 is small.
The flocculant is chitosan and/or silica-starch-sodium carboxymethylcellulose.Preferably, the flocculant
It is chitosan and silica-starch-sodium carboxymethylcellulose with mass ratio 1：(2.5~3) mixture of composition.
The preparation process of the silica-starch-sodium carboxymethylcellulose is：1.5~2g sodium metasilicate is weighed, add 30~
40mL water, mixing adjust the pH value of mixed liquor to 5~6 with hydrochloric acid, with 80~170 revs/min of stirrings 2~3 it is small when, obtain oxygen
SiClx colloid；After nitrogen being passed through into silicon oxide colloid 20~30 minutes, add in 1.5~2g starch, in 75~80 DEG C react 2~
3 it is small when；It is inclined then to add in 0.8~1g sodium carboxymethylcelluloses, 0.003~0.004g manganese pyrophosphates and 0.001~0.003g tri-
Sodium phosphate, when 75~85 DEG C of reactions 4~6 are small, collecting reaction product；60~80mL absolute ethyl alcohols are added in into reaction product,
With 100~200 revs/min stirring 24~48 it is small when after, with 2000~3000 revs/min centrifuge 10~15 minutes, collect bottom
Solid；By bottom solid when drying 10~12 is small under conditions of 40~50 DEG C, 0.07~0.08MPa of vacuum degree, obtain described
Silica-starch-sodium carboxymethylcellulose.
By the way that green non-poisonous natural material silica, starch and carboxymethyl cellulose are combined, starch and carboxylic first
Dehydration is crosslinked between hydroxyl on base sodium cellulosate molecule, obtains the flocculant that active group is more, flocculation efficiency is high
Silica-starch-sodium carboxymethylcellulose.
The second technical problem to be solved by the present invention is to provide a kind of dental implant method.
It is recessed from tooth after taking any of the above-described kind for the middle liquid medicine of oral tooth implantation the present invention also provides a kind of dental implant method
Tooth is extracted in slot, is drilled, inserts bone mixture, places and plants tooth body.
Middle liquid medicine of the present invention for oral tooth implantation can both contain and gargle, can also take or smear, dental implant surgical
It is front and rear to use.
Middle liquid medicine of the present invention for oral tooth implantation during tooth-implanting operation, can effectively control operative region
Pain, inflammation and swelling, reduce postoperative infection and swelling, effectively promote plantation success rate, while have what high-effective disinfecting was sterilized
Effect effectively prevents peri-implantitiss, further extension tooth-implanting and remaining natural teeth service life, extensive after desmopyknosis
The multiple time.
Specific embodiment
Each raw material introduction in embodiment：
Honeysuckle (scientific name：Lonicera japonica) also known as honeysuckle.Property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature is without hindering
Stomach, fragrance reaches thoroughly again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison.The honeysuckle used in embodiment is purchased from
Bozhou City Sheng Hao bio tech ltd.Using preceding when 40 DEG C of dryings 8 are small.
Dandelion (scientific name：Taraxacum mongolicum Hand.-Mazz.), composite family, Dandelion perennial herb
Plant.Alias dandelion, Po Poding, Hua Hualang.There is the effect of clearing heat and detoxicating.The dandelion used in embodiment is purchased from Bozhou
City oozes fragrant flower tea Co., Ltd.Using preceding when 40 DEG C of dryings 8 are small.
Subprostrate sophora (scientific name：Euchresta japonica), three leaflet subprostrate sophora of alias, lima bean lotus are planted for pulse family pulse family
The dry root and rhizome of object sophora tonkinensis Gapnep.《Kaibao Bencao》It records, all medicine poison of principal solution, analgesic.Disappear pyogenic infections from tumour or sore, acute febrile fever and cough,
Kill small worm.The subprostrate sophora used in embodiment is purchased from Bozhou City medicine company sale Co., Ltd of one mind.Using preceding small in 40 DEG C of dryings 8
When.
Curcuma zedoary (scientific name：Curcuma zedoaria (Christm.) Rosc), nickname cowherb medicine, cowherb cyclopentadienyl, blue or green ginger, evil mind ginger,
Turmeric is perennial herb.With promoting qi circulation and relieving pain, the effect of blood-breaking disperse accumulation.The curcuma zedoary used in embodiment is purchased from Bozhou
Wan Bei medicine companies Co., Ltd of city.Using preceding when 40 DEG C of dryings 8 are small.
Sucrose, food-grade, purchased from the permanent bio tech ltd in Guangdong thousand.
Chitosan, food-grade, purchased from one hundred emerging bio tech ltd of Wuhan, deacetylation 90%.
Sodium metasilicate, purchased from Shenzhen Huifeng ocean Science and Technology Ltd..
Starch, food-grade, the specific cornstarch provided using Jinan Hong Xu Chemical Co., Ltd.s.
Sodium carboxymethylcellulose, food-grade, purchased from one hundred emerging bio tech ltd of Wuhan.
Manganese pyrophosphate, purchased from the happy Industrial Co., Ltd.s of Shanghai Jin Jin.
Sodium trimetaphosphate, No. CAS：7785-84-4, food-grade, purchased from the more food ingredient Co., Ltds in Jiangsu Cologne.
Embodiment 1
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；Claim
Extracting honeysuckle powder adds in distilled water according to liquid ratio 12mL/g, when 90 DEG C of extractions 4 are small, obtains extracting solution；Extracting solution is adopted
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Into concentrate
It adds in absolute ethyl alcohol to ethanol content and reaches 80wt%, stirred 15 minutes with 30 revs/min, obtain mixed liquor；By mixed liquor in
It when 10 DEG C of standings 20 are small, is centrifuged 25 minutes with 3000 revs/min, collects supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
To the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h,
15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.With reference to《Green original in folium cortex eucommiae
The research of acid content detection》(Lan little Yan, Chinese animal and veterinary, the 14th phase of volume 37 in 2010) is to green original in Honegsukle flower P.E
Acid content is measured, and the content for the Honegsukle flower P.E Content of Chlorogenic Acid that 1g honeysuckles obtain is 106.267 μ g.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder adds in distilled water according to liquid ratio 12mL/g, when refluxing extraction 2 is small, obtains extracting solution；Extracting solution is filtered using 300 mesh
After cloth filtering, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；It is added in into concentrate anhydrous
Ethyl alcohol to ethanol content reaches 80wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor；By mixed liquor in 10 DEG C of standings
20 it is small when, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, the cowherb is obtained
Art extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, sublimation temperature 15
DEG C, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；Claim
Vietnamese Sophora Root is taken, distilled water is added according to liquid ratio 12mL/g, when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；To concentrate
Middle addition absolute ethyl alcohol to ethanol content reaches 80wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor；By mixed liquor
When 10 DEG C of standings 20 are small, centrifuged 25 minutes with 3000 revs/min, collect supernatant liquor；By supernatant liquor vacuum freeze drying,
Obtain the sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 are small
When, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
Embodiment 2
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；Claim
Extracting honeysuckle powder adds in distilled water according to liquid ratio 12mL/g, when 90 DEG C of extractions 4 are small, obtains extracting solution；Extracting solution is adopted
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Into concentrate
It adds in absolute ethyl alcohol to ethanol content and reaches 60wt%, stirred 15 minutes with 30 revs/min, obtain mixed liquor I；Then to mixing
Absolute ethyl alcohol to ethanol content is added in liquid I and reaches 70wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor II；Continue
Absolute ethyl alcohol to ethanol content is added in into mixed liquor II and reaches 80wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor
Ⅲ；By mixed liquor III when 10 DEG C of standings 20 are small, centrifuged 25 minutes with 3000 revs/min, collect supernatant liquor；By supernatant liquor
Vacuum freeze drying obtains the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature,
Pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.Ginseng
It examines《The research of Chlorogenic Acid in Eucommia ulmoides Oliv. Leaves content detection》(Lan little Yan, Chinese animal and veterinary, the 14th phase of volume 37 in 2010) is to gold
Honeysuckle flower extract Content of Chlorogenic Acid is measured, and the content for the Honegsukle flower P.E Content of Chlorogenic Acid that 1g honeysuckles obtain is
114.183μg。
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder adds in distilled water according to liquid ratio 12mL/g, when refluxing extraction 2 is small, obtains extracting solution；Extracting solution is filtered using 300 mesh
After cloth filtering, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；It is added in into concentrate anhydrous
Ethyl alcohol to ethanol content reaches 60wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor I；Add then in mixed liquor I
Enter absolute ethyl alcohol to ethanol content and reach 70wt%, stirred 15 minutes with 30 revs/min, obtain mixed liquor II；Continue to mixing
Absolute ethyl alcohol to ethanol content is added in liquid II and reaches 80wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor III；It will
Mixed liquor III is centrifuged 25 minutes with 3000 revs/min when 10 DEG C of standings 20 are small, collects supernatant liquor；By supernatant liquor vacuum
Freeze-drying, obtains the Rhizoma Curcumae extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, during pre-freeze
Between 2 it is small when, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；Claim
Vietnamese Sophora Root is taken, distilled water is added according to liquid ratio 12mL/g, when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；To concentrate
Middle addition absolute ethyl alcohol to ethanol content reaches 60wt%, is stirred 15 minutes with 30 revs/min, obtains mixed liquor I；Then to mixed
It closes addition absolute ethyl alcohol to ethanol content in liquid I and reaches 70wt%, stirred 15 minutes with 30 revs/min, obtain mixed liquor II；After
Continue addition absolute ethyl alcohol to the ethanol content into mixed liquor II and reach 80wt%, stirred 15 minutes, mixed with 30 revs/min
Liquid III；By mixed liquor III when 10 DEG C of standings 20 are small, centrifuged 25 minutes with 3000 revs/min, collect supernatant liquor；Upper strata is clear
Liquid vacuum freeze drying obtains the sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -25
DEG C, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
Embodiment 3
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；Claim
Extracting honeysuckle powder adds in distilled water according to liquid ratio 12mL/g, when 90 DEG C of extractions 4 are small, obtains extracting solution；Extracting solution is adopted
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Into concentrate
Add in the chitosan of 0.003 times of concentrate weight, with 30 revs/min of stirrings flocculate 4 it is small when after, with 3000 revs/min of centrifugations 25
Minute, collect supernatant liquor；By supernatant liquor vacuum freeze drying, the Honegsukle flower P.E is obtained；Wherein vacuum refrigeration is done
Dry process conditions are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C of resolution temperature, vacuum degree
0.096MPa, when vacuum drying time 24 is small.With reference to《The research of Chlorogenic Acid in Eucommia ulmoides Oliv. Leaves content detection》(Lan little Yan, China poultry
Herd animal doctor, the 14th phase of volume 37 in 2010) Honegsukle flower P.E Content of Chlorogenic Acid is measured, the gold that 1g honeysuckles obtain
The content of honeysuckle flower extract Content of Chlorogenic Acid is 125.956 μ g.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder adds in distilled water according to liquid ratio 12mL/g, when refluxing extraction 2 is small, obtains extracting solution；Extracting solution is filtered using 300 mesh
After cloth filtering, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Concentration is added in into concentrate
The chitosan that 0.003 times of liquid weight, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect
Supernatant liquor；By supernatant liquor vacuum freeze drying, the Rhizoma Curcumae extract is obtained；The wherein process conditions of vacuum freeze drying
For：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, vacuum
When drying time 24 is small.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；Claim
Vietnamese Sophora Root is taken, distilled water is added according to liquid ratio 12mL/g, when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution
After 300 mesh filter-cloth filterings, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；To concentrate
The middle chitosan for adding in 0.003 times of concentrate weight, with 30 revs/min of stirrings flocculate 4 it is small when after, with 3000 revs/min of centrifugations
25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, the sophorae subprostratae radix extract is obtained；Wherein vacuum refrigeration
Dry process conditions are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C of resolution temperature, vacuum degree
0.096MPa, when vacuum drying time 24 is small.
Embodiment 4
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；It adopts
The pH to 8.4 of distilled water is adjusted with the sodium bicarbonate aqueous solution of molar concentration 10mmol/L；Honeysuckle Flower is weighed, according to liquid material
Than the distilled water that 12mL/g adds in pH 8.4, when 90 DEG C of extractions 4 are small, extracting solution is obtained；Extracting solution is used into 300 mesh filter cloth mistakes
After filter, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Using molar concentration 10mmol/L's
Hydrochloric acid adjusts the pH to 6.2 of concentrate, and the chitosan of 0.003 times of concentrate weight is added in into concentrate, is stirred with 30 revs/min
Mix flocculation 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
To the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h,
15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.With reference to《Green original in folium cortex eucommiae
The research of acid content detection》(Lan little Yan, Chinese animal and veterinary, the 14th phase of volume 37 in 2010) is to green original in Honegsukle flower P.E
Acid content is measured, and the content for the Honegsukle flower P.E Content of Chlorogenic Acid that 1g honeysuckles obtain is 147.348 μ g.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder adds in distilled water according to liquid ratio 12mL/g, when refluxing extraction 2 is small, obtains extracting solution；Extracting solution is filtered using 300 mesh
After cloth filtering, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Concentration is added in into concentrate
The chitosan that 0.003 times of liquid weight, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect
Supernatant liquor；By supernatant liquor vacuum freeze drying, the Rhizoma Curcumae extract is obtained；The wherein process conditions of vacuum freeze drying
For：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, vacuum
When drying time 24 is small.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；It adopts
The pH to 2 of distilled water is adjusted with the hydrochloric acid of molar concentration 10mmol/L；Vietnamese Sophora Root is weighed, is added according to liquid ratio 12mL/g
The distilled water of pH 2 when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution using after 300 mesh filter-cloth filterings, in 55 DEG C,
When concentration 2 is small under conditions of vacuum degree 0.07MPa, concentrate is obtained；Sodium acid carbonate using molar concentration 10mmol/L is water-soluble
Liquid adjusts the pH to 9.1 of concentrate, and the chitosan of 0.003 times of concentrate weight is added in into concentrate, with 30 revs/min of stirrings
Flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
The sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h rise
Magnificent 15 DEG C of temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
Embodiment 5
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；It adopts
The pH to 8.4 of distilled water is adjusted with the sodium bicarbonate aqueous solution of molar concentration 10mmol/L；Honeysuckle Flower is weighed, according to liquid material
Than the distilled water that 12mL/g adds in pH 8.4, when 90 DEG C of extractions 4 are small, extracting solution is obtained；Extracting solution is used into 300 mesh filter cloth mistakes
After filter, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Using molar concentration 10mmol/L's
Hydrochloric acid adjusts the pH to 6.2 of concentrate, and the chitosan of 0.003 times of concentrate weight is added in into concentrate, is stirred with 30 revs/min
Mix flocculation 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
To the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h,
15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder is placed in pressurised extraction tank, and distilled water, sealing pressing extractor, in extraction pressure are added according to liquid ratio 12mL/g
It is extracted 40 minutes under conditions of 0.7MPa, 100 DEG C of Extracting temperature, obtains extracting solution；Extracting solution is used into 300 mesh filter-cloth filterings
Afterwards, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Concentrate weight is added in into concentrate
0.003 times of chitosan, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect upper strata it is clear
Liquid；By supernatant liquor vacuum freeze drying, the Rhizoma Curcumae extract is obtained；The process conditions of wherein vacuum freeze drying are：In advance
Freeze -25 DEG C of temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, during vacuum drying
Between 24 it is small when.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；It adopts
The pH to 2 of distilled water is adjusted with the hydrochloric acid of molar concentration 10mmol/L；Vietnamese Sophora Root is weighed, is added according to liquid ratio 12mL/g
The distilled water of pH 2 when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution using after 300 mesh filter-cloth filterings, in 55 DEG C,
When concentration 2 is small under conditions of vacuum degree 0.07MPa, concentrate is obtained；Sodium acid carbonate using molar concentration 10mmol/L is water-soluble
Liquid adjusts the pH to 9.1 of concentrate, and the chitosan of 0.003 times of concentrate weight is added in into concentrate, with 30 revs/min of stirrings
Flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
The sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h rise
Magnificent 15 DEG C of temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
Embodiment 6
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；It adopts
The pH to 8.4 of distilled water is adjusted with the sodium bicarbonate aqueous solution of molar concentration 10mmol/L；Honeysuckle Flower is weighed, according to liquid material
Than the distilled water that 12mL/g adds in pH 8.4, when 90 DEG C of extractions 4 are small, extracting solution is obtained；Extracting solution is used into 300 mesh filter cloth mistakes
After filter, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Using molar concentration 10mmol/L's
Hydrochloric acid adjusts the pH to 6.2 of concentrate, and silica-starch-carboxymethyl of 0.003 times of concentrate weight is added in into concentrate
Sodium cellulosate, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；It will be upper
Layer clear liquid vacuum freeze drying, obtains the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：Pre-freeze temperature
- 25 DEG C of degree, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, vacuum drying time 24
Hour.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder is placed in pressurised extraction tank, and distilled water, sealing pressing extractor, in extraction pressure are added according to liquid ratio 12mL/g
It is extracted 40 minutes under conditions of 0.7MPa, 100 DEG C of Extracting temperature, obtains extracting solution；Extracting solution is used into 300 mesh filter-cloth filterings
Afterwards, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Concentrate weight is added in into concentrate
0.003 times of silica-starch-sodium carboxymethylcellulose, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min
Zhongli's heart 25 minutes collects supernatant liquor；By supernatant liquor vacuum freeze drying, the Rhizoma Curcumae extract is obtained；Wherein vacuum
The process conditions of freeze-drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C of resolution temperature, very
Reciprocal of duty cycle 0.096MPa, when vacuum drying time 24 is small.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；It adopts
The pH to 2 of distilled water is adjusted with the hydrochloric acid of molar concentration 10mmol/L；Vietnamese Sophora Root is weighed, is added according to liquid ratio 12mL/g
The distilled water of pH 2 when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution using after 300 mesh filter-cloth filterings, in 55 DEG C,
When concentration 2 is small under conditions of vacuum degree 0.07MPa, concentrate is obtained；Sodium acid carbonate using molar concentration 10mmol/L is water-soluble
Liquid adjusts the pH to 9.1 of concentrate, and silica-starch-carboxymethyl that 0.003 times of concentrate weight is added in into concentrate is fine
The plain sodium of dimension, with 30 revs/min of stirrings flocculate 4 it is small when after, centrifuged 25 minutes with 3000 revs/min, collect supernatant liquor；By upper strata
Clear liquid vacuum freeze drying obtains the sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature-
25 DEG C, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, vacuum drying time 24 is small
When.
The preparation process of the silica-starch-sodium carboxymethylcellulose is：2g sodium metasilicate is weighed, adds 40mL water, is mixed
Close, the pH value of mixed liquor adjusted to 6 with hydrochloric acid, with 170 revs/min of stirrings 3 it is small when, obtain silicon oxide colloid；To silica gel
After nitrogen being passed through in body 30 minutes, 2g starch is added in, when 80 DEG C of reactions 3 are small；Subsequent addition 1g sodium carboxymethylcelluloses,
0.004g manganese pyrophosphates and 0.003g sodium trimetaphosphates, when 85 DEG C of reactions 6 are small, collecting reaction product；Add into reaction product
Enter 80mL absolute ethyl alcohols, with 200 revs/min stirring 48 it is small when after, with 3000 revs/min centrifuge 15 minutes, collect bottom solid；
By bottom solid when drying 12 is small under conditions of 50 DEG C, vacuum degree 0.08MPa, the silica-starch-carboxymethyl is obtained
Sodium cellulosate.
Embodiment 7
For the middle liquid medicine (raw material) of oral tooth implantation：Honegsukle flower P.E 10g, dandelion extract 15g, subprostrate sophora extraction
Object 7g, Rhizoma Curcumae extract 10g, sucrose 15g, water 1200g.Each raw material is added to the water and is uniformly mixed up to for oral tooth implantation
Middle liquid medicine.
The preparation process of the Honegsukle flower P.E is：Honeysuckle is crushed, 70 mesh sieves is crossed, obtains Honeysuckle Flower；It adopts
The pH to 8.4 of distilled water is adjusted with the sodium bicarbonate aqueous solution of molar concentration 10mmol/L；Honeysuckle Flower is weighed, according to liquid material
Than the distilled water that 12mL/g adds in pH 8.4, when 90 DEG C of extractions 4 are small, extracting solution is obtained；Extracting solution is used into 300 mesh filter cloth mistakes
After filter, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Using molar concentration 10mmol/L's
Hydrochloric acid adjusts the pH to 6.2 of concentrate, and the flocculant of 0.003 times of concentrate weight is added in into concentrate, and the flocculant is
Chitosan and silica-starch-sodium carboxymethylcellulose are with mass ratio 1：The mixture of 2.5 compositions, with 30 revs/min of stirrings
Flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
The Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h rise
Magnificent 15 DEG C of temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
The preparation method of the dandelion extract is identical with the preparation method of Honegsukle flower P.E, and honeysuckle is replaced with
Dandelion.
The preparation process of the Rhizoma Curcumae extract is：Curcuma zedoary is crushed, 70 mesh sieves is crossed, obtains Zedoary Rhizome；Weigh curcuma zedoary
Powder is placed in pressurised extraction tank, and distilled water, sealing pressing extractor, in extraction pressure are added according to liquid ratio 12mL/g
It is extracted 40 minutes under conditions of 0.7MPa, 100 DEG C of Extracting temperature, obtains extracting solution；Extracting solution is used into 300 mesh filter-cloth filterings
Afterwards, when concentration 2 is small under conditions of 55 DEG C, vacuum degree 0.07MPa, concentrate is obtained；Concentrate weight is added in into concentrate
0.003 times of flocculant, the flocculant are chitosan and silica-starch-sodium carboxymethylcellulose with mass ratio 1：2.5
The mixture of composition, with 30 revs/min stirring flocculate 4 it is small when after, with 3000 revs/min centrifuge 25 minutes, collect supernatant liquor；
By supernatant liquor vacuum freeze drying, the Rhizoma Curcumae extract is obtained；The process conditions of wherein vacuum freeze drying are：Pre-freeze temperature
- 25 DEG C of degree, pre-freeze time 2 h, 15 DEG C of sublimation temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, vacuum drying time 24
Hour.
The preparation process of the sophorae subprostratae radix extract is：Subprostrate sophora is crushed, 70 mesh sieves is crossed, obtains Vietnamese Sophora Root；It adopts
The pH to 2 of distilled water is adjusted with the hydrochloric acid of molar concentration 10mmol/L；Vietnamese Sophora Root is weighed, is added according to liquid ratio 12mL/g
The distilled water of pH 2 when 60 DEG C of extractions 12 are small, obtains extracting solution；By extracting solution using after 300 mesh filter-cloth filterings, in 55 DEG C,
When concentration 2 is small under conditions of vacuum degree 0.07MPa, concentrate is obtained；Sodium acid carbonate using molar concentration 10mmol/L is water-soluble
Liquid adjusts the pH to 9.1 of concentrate, and the flocculant of 0.003 times of concentrate weight is added in into concentrate, and the flocculant is shell
Glycan and silica-starch-sodium carboxymethylcellulose are with mass ratio 1：The mixture of 2.5 compositions is wadded a quilt with cotton with 30 revs/min of stirrings
It is solidifying 4 it is small when after, centrifuged 25 minutes with 3000 revs/min, collect supernatant liquor；By supernatant liquor vacuum freeze drying, institute is obtained
State sophorae subprostratae radix extract；The process conditions of wherein vacuum freeze drying are：- 25 DEG C of pre-freezing temperature, pre-freeze time 2 h, distillation
15 DEG C of temperature, 30 DEG C, vacuum degree 0.096MPa of resolution temperature, when vacuum drying time 24 is small.
The preparation process of the silica-starch-sodium carboxymethylcellulose is：2g sodium metasilicate is weighed, adds 40mL water, is mixed
Close, the pH value of mixed liquor adjusted to 6 with hydrochloric acid, with 170 revs/min of stirrings 3 it is small when, obtain silicon oxide colloid；To silica gel
After nitrogen being passed through in body 30 minutes, 2g starch is added in, when 80 DEG C of reactions 3 are small；Subsequent addition 1g sodium carboxymethylcelluloses,
0.004g manganese pyrophosphates and 0.003g sodium trimetaphosphates, when 85 DEG C of reactions 6 are small, collecting reaction product；Add into reaction product
Enter 80mL absolute ethyl alcohols, with 200 revs/min stirring 48 it is small when after, with 3000 revs/min centrifuge 15 minutes, collect bottom solid；
By bottom solid when drying 12 is small under conditions of 50 DEG C, vacuum degree 0.08MPa, the silica-starch-carboxymethyl is obtained
Sodium cellulosate.
Test case 1
Embodiment 1-7 is tested for the analgesic effect of the middle liquid medicine of oral tooth implantation.
20 ± 5g healthy mices (spf grades, Beijing Vital River Experimental Animals Technology Co., Ltd.) are taken, it is random to be grouped, often
Group 8.Experimental group gavages the middle liquid medicine for oral tooth implantation according to dosage 0.02mL/g weight, and blank group gavages normal salt
Water.After taking liquid medicine 30 minutes, 0.6% glacial acetic acid solution is only injected intraperitoneally according to 0.2mL/, observes and remembers immediately after
Record the number that every mouse in 15 minutes generates writhing response (indent, hips up are shunk in flexible hind leg, abdominal cavity).Specific test
It the results are shown in Table 1.
Table 1：Analgesic effect test result table
Test case 2
Embodiment 1-7 is tested for the antiphlogistic effects of the middle liquid medicine of oral tooth implantation, it is penetrating with abdominal cavity capillary
Property rejection ability is as index.
Configure Evans blue normal saline solution：Precision weighs Evans blue solid (the limited public affairs of upper Asteriidae biotechnology
Department provide) 0.50g into 100mL volumetric flasks, add physiological saline solution and be settled to scale to get.
20 ± 5g healthy mices (spf grades, Beijing Vital River Experimental Animals Technology Co., Ltd.) are taken, it is random to be grouped, often
Group 8.Experimental group gavages the middle liquid medicine for oral tooth implantation according to dosage 0.02mL/g weight, and blank group gavages normal salt
Water.After taking liquid medicine 30 minutes, according to every mouse tail vein injection Evans blue normal saline solution of 0.1mL/10g, with
After intraperitoneal injection dimethylbenzene 0.2m L/ only.After twenty minutes, mouse takes off neck execution, abdominal cavity is cut off, with 4mL normal saline flushings
Abdominal cavity twice, merges washing lotion, and physiological saline is added to be centrifuged 10 minutes in 3000 revs/min to 10m L, supernatant is taken, with physiology salt
Water is reference solution, and light absorption value is measured at 590nm.
According to Evans blue standard curve, each sample is calculated to mouse peritoneal capillary permeability inhibiting rate, is calculated public
Formula is as follows：Abdominal cavity capillary permeability inhibiting rate/%=(1-CSample/CIt is empty) × 100%.Wherein, CSampleYi Wen is oozed out for experimental group
Think blue concentration, CIt is emptyThe concentration of Evans blue is oozed out for blank group.Specific test result is shown in Table 2.
Table 2：Antiphlogistic effects test result table
The above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not to the present invention
Embodiment restriction.For those of ordinary skill in the art, can also make on the basis of the above description
Other various forms of variations or variation.Here all embodiments can not be exhaustive.Every skill for belonging to the present invention
The obvious changes or variations that art scheme is extended out is still in the row of protection scope of the present invention.
Claims (9)
1. a kind of middle liquid medicine for oral tooth implantation, which is characterized in that the middle liquid medicine for oral tooth implantation includes following original
Material：Honegsukle flower P.E, dandelion extract, sophorae subprostratae radix extract, Rhizoma Curcumae extract, sucrose and water.
2. a kind of middle liquid medicine for oral tooth implantation according to claim 1, which is characterized in that by the original of following parts by weight
Material is prepared：10~20g of Honegsukle flower P.E, 10~20g of dandelion extract, 3~7g of sophorae subprostratae radix extract, curcuma zedoary extraction
5~10g of object, 8~15g of sucrose, 800~1200g of water.
A kind of 3. middle liquid medicine for oral tooth implantation according to claim 2, which is characterized in that the Honegsukle flower P.E
Preparation process be：Honeysuckle is crushed, 40-70 mesh sieves is crossed, obtains Honeysuckle Flower；Honeysuckle Flower is weighed, according to liquid material
Distilled water is added in than 10~12mL/g, when 80~90 DEG C of extractions 2~4 are small, obtains extracting solution；Extracting solution is used 200~300
After mesh filter-cloth filtering, when concentration 1~2 is small under conditions of 50~55 DEG C, 0.06~0.07MPa of vacuum degree, concentrate is obtained；To
Absolute ethyl alcohol to ethanol content is added in concentrate and reaches 50~60wt%, is stirred 10~15 minutes, obtained with 20~30 revs/min
To mixed liquor I；Reach 60~70wt% then to absolute ethyl alcohol to ethanol content is added in mixed liquor I, with 20~30 revs/min
Stirring 10~15 minutes, obtains mixed liquor II；Continue to add in into mixed liquor II absolute ethyl alcohol to ethanol content reach 70~
80wt% is stirred 10~15 minutes with 20~30 revs/min, obtains mixed liquor III；By mixed liquor III in 5~10 DEG C stand 12~
20 it is small when, with 2000~3000 revs/min centrifuge 15~25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying,
Obtain the Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, pre-freeze time
1~2 it is small when, 5~15 DEG C of sublimation temperature, 25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, vacuum drying time 16
~24 it is small when.
A kind of 4. middle liquid medicine for oral tooth implantation according to claim 2, which is characterized in that the Honegsukle flower P.E
Preparation process be：Honeysuckle is crushed, 40-70 mesh sieves is crossed, obtains Honeysuckle Flower；Honeysuckle Flower is weighed, according to liquid material
Distilled water is added in than 10~12mL/g, when 80~90 DEG C of extractions 2~4 are small, obtains extracting solution；Extracting solution is used 200~300
After mesh filter-cloth filtering, when concentration 1~2 is small under conditions of 50~55 DEG C, 0.06~0.07MPa of vacuum degree, concentrate is obtained；To
The flocculant of 0.001~0.005 times of concentrate weight is added in concentrate, with 20~30 revs/min of stirrings flocculate 3~4 it is small when
Afterwards, centrifuged 15~25 minutes with 2000~3000 revs/min, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain
The Honegsukle flower P.E；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, pre-freeze time 1~2
Hour, 5~15 DEG C of sublimation temperature, 25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, vacuum drying time 16~24
Hour.
A kind of 5. middle liquid medicine for oral tooth implantation according to claim 2, which is characterized in that the Honegsukle flower P.E
Preparation process be：Honeysuckle is crushed, 40-70 mesh sieves is crossed, obtains Honeysuckle Flower；Using 5~10mmol/L of molar concentration
Sodium bicarbonate aqueous solution adjust distilled water pH to 8.4~8.5；Honeysuckle Flower is weighed, according to 10~12mL/g of liquid ratio
The distilled water of pH 8.4~8.5 is added in, when 80~90 DEG C of extractions 2~4 are small, obtains extracting solution；By extracting solution using 200~
After 300 mesh filter-cloth filterings, when concentration 1~2 is small under conditions of 50~55 DEG C, 0.06~0.07MPa of vacuum degree, concentrated
Liquid；The pH to 6.1~6.2 of concentrate is adjusted using the hydrochloric acid of 5~10mmol/L of molar concentration, concentrate is added in into concentrate
The flocculant that 0.001~0.005 times of weight, with 20~30 revs/min stirring flocculate 3~4 it is small when after, with 2000~3000 turns/
Minute centrifugation 15~25 minutes, collects supernatant liquor；By supernatant liquor vacuum freeze drying, the Honegsukle flower P.E is obtained；
The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, sublimation temperature 5~
15 DEG C, 25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, when vacuum drying time 16~24 is small.
6. a kind of middle liquid medicine for oral tooth implantation according to claim 2, which is characterized in that the Rhizoma Curcumae extract
Preparation process is：Curcuma zedoary is crushed, 40-70 mesh sieves is crossed, obtains Zedoary Rhizome；Zedoary Rhizome is weighed, is placed in pressurised extraction tank,
Distilled water, sealing pressing extractor, in extraction 0.6~0.7MPa of pressure, Extracting temperature are added according to 10~12mL/g of liquid ratio
It is extracted 30~50 minutes under conditions of 90~100 DEG C, obtains extracting solution；After extracting solution is used 200~300 mesh filter-cloth filterings,
When concentration 1~2 is small under conditions of 50~55 DEG C, 0.06~0.07MPa of vacuum degree, concentrate is obtained；It is added in into concentrate
The flocculant that 0.001~0.005 times of concentrate weight, with 20~30 revs/min of stirrings flocculate 3~4 it is small when after, with 2000~
3000 revs/min centrifuge 15~25 minutes, collect supernatant liquor；By supernatant liquor vacuum freeze drying, obtain the curcuma zedoary and carry
Take object；The process conditions of wherein vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, distillation temperature
5~15 DEG C of degree, 25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, when vacuum drying time 16~24 is small.
A kind of 7. middle liquid medicine for oral tooth implantation according to claim 2, which is characterized in that the sophorae subprostratae radix extract
Preparation method be：Subprostrate sophora is crushed, 40-70 mesh sieves is crossed, obtains Vietnamese Sophora Root；Using 5~10mmol/L of molar concentration
Hydrochloric acid adjust distilled water pH to 1~2；Vietnamese Sophora Root is weighed, the steaming of pH 1~2 is added according to 10~12mL/g of liquid ratio
Distilled water when 50~60 DEG C of extractions 12~16 are small, obtains extracting solution；After extracting solution is used 200~300 mesh filter-cloth filterings, in
50~55 DEG C, when concentration 1~2 is small under conditions of 0.06~0.07MPa of vacuum degree, obtain concentrate；Using molar concentration 5~
The sodium bicarbonate aqueous solution of 10mmol/L adjusts the pH to 9.1~9.2 of concentrate, and concentrate weight is added in into concentrate
0.001~0.005 times of flocculant, with 20~30 revs/min stirring flocculate 3~4 it is small when after, with 2000~3000 revs/min
Supernatant liquor is collected in centrifugation 15~25 minutes；By supernatant liquor vacuum freeze drying, the sophorae subprostratae radix extract is obtained；Wherein
The process conditions of vacuum freeze drying are：Pre-freezing temperature -20~-25 DEG C, when the pre-freeze time 1~2 is small, 5~15 DEG C of sublimation temperature,
25~30 DEG C, 0.09~0.096MPa of vacuum degree of resolution temperature, when vacuum drying time 16~24 is small.
A kind of 8. middle liquid medicine for oral tooth implantation according to any one of claim 4-7, which is characterized in that the wadding
Solidifying agent is chitosan and/or silica-starch-sodium carboxymethylcellulose.
9. a kind of dental implant method, which is characterized in that take the Chinese medicine for oral tooth implantation any one of claim 1-8
After water, tooth is extracted from tooth groove, is drilled, inserts bone mixture, places and plants tooth body.
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| CN110893121A (en) * | 2018-09-13 | 2020-03-20 | 光弘生医科技股份有限公司 | Implant structure and preparation method thereof |
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