CN110893121A - Implant structure and preparation method thereof - Google Patents
Implant structure and preparation method thereof Download PDFInfo
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- CN110893121A CN110893121A CN201811068588.9A CN201811068588A CN110893121A CN 110893121 A CN110893121 A CN 110893121A CN 201811068588 A CN201811068588 A CN 201811068588A CN 110893121 A CN110893121 A CN 110893121A
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- implant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Ceramic Engineering (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
The invention discloses a plant structure and a preparation method thereof, wherein the preparation method comprises the following steps: providing a finished implant product; decomposing a monomer containing silicon oxygen molecules (Siloxane) into an ionic state, and forming a coating film on the surface of the implant; attaching a cross-linking agent capable of generating covalent bond combination with the siloxane coating on the surface of the implant; coating functional molecules outside the cross-linking agent to generate chemical bonds and retain the chemical bonds on the surface of the implant, thereby completing the plasma coating and molecular cross-linking structure of the implant.
Description
Technical Field
The invention relates to the field of tooth implantation, in particular to an implant structure and a preparation method thereof.
Background
Generally, an intra-osseous implant such as an artificial tooth root (implant) requires several months of recovery after surgery to allow bone to regrow and bond with the implant, otherwise known as osseointegration. The efficiency of osseointegration is directly related to the stability of the implant, and when the implant is shaken, osseointegration cannot be performed, so that a physician usually performs an operation by making the size of the implant slightly larger than the size of the hole in the bone, and the bone presses the implant to generate better initial stability.
Within two weeks after the tooth implantation operation, the damaged bone can be decomposed and absorbed by the human body, and at the moment, the implant can be loosened.
However, when the implant is shaken by force, the bone cells can not grow, and the osseointegration fails, and therefore, the success rate of the conventional tooth implantation is generally low.
In addition, in the period of osseointegration of the implant, the implant does not have a vascular network like a natural bone, and the implant has poor inhibition to germs, so complications such as peri-implant inflammation are easily caused, and if the patient cannot clean the oral cavity and then the peri-implant inflammation is caused, the failure rate of the implant is as high as 20-30%.
Therefore, when a patient is implanted in a tooth implantation operation, the implant is immediately exposed to the harsh environment of the oral cavity and needs to bear mechanical force and germ growth when the patient chews, and the success rate of tooth implantation is greatly reduced.
Therefore, the conventional tooth implantation method has many defects, and is not a good designer, and needs to be improved.
In view of the disadvantages derived from the conventional dental implant methods, the inventors of the present invention have earnestly studied and innovated, and after many years of research with a spice, have succeeded in developing patent patents.
Disclosure of Invention
In view of the shortcomings of the prior art, it is an object of the present invention to provide a method for preparing an implant structure.
In order to achieve the purpose, the invention adopts the technical scheme that:
a preparation method of an implant structure comprises the following steps:
step 1: providing a finished implant product;
step 2: decomposing a monomer containing silicon-oxygen molecules into an ion state, and forming a coating on the surface of the implant;
and step 3: attaching or coating or soaking a cross-linking agent capable of generating covalent bond combination with the siloxane coating on the surface of the implant;
and 4, step 4: coating functional molecules outside the cross-linking agent to generate chemical bonds and keep the chemical bonds on the surface of the implant.
The cross-linking agent is a chemical cross-linking agent or a natural cross-linking agent or a combination thereof, and is molecular viscose.
The cross-linking agent is genipin or procyanidin.
The functional molecule is a bone growth promoting molecule for shortening osseointegration time.
The functional molecule is an antibacterial molecule and is used for reducing the incidence rate of periphyton inflammation.
It is another object of the present invention to provide an implant structure, comprising:
the implant body comprises an artificial tooth root and a base arranged on the artificial tooth root;
coating a film on the surface of the implant by using a monomer containing a silica molecule;
the cross-linking agent is attached to the surface of the coated implant;
the functional molecule is attached to or coated on or soaked outside the cross-linking agent and generates chemical bonding, so that the functional molecule is kept on the surface of the implant.
The monomer containing the silicon oxygen molecules is decomposed into an ion state and then coated on the surface of the implant.
The cross-linking agent is a chemical cross-linking agent or a natural cross-linking agent or a combination thereof, and is molecular viscose.
The functional molecule is a bone growth promoting molecule or an antibacterial molecule.
The cross-linking agent is genipin or procyanidin.
The invention has the beneficial effects that:
through the structure and the method, the implant is cross-linked through the coating and the molecules, and provides corresponding functions of the implant according to different functional molecules, for example, the bone growth promoting molecules are used for shortening the osseointegration time and shortening the treatment course, and the antibacterial molecules are used for reducing the incidence of peri-implantitis, thereby improving the success of the tooth implantation operation.
Drawings
FIG. 1 is a schematic view of the process for preparing the implant structure according to the present invention.
Fig. 2 is a schematic structural view of the implant structure of the present invention.
Fig. 3 is a partially enlarged structural view of the implant structure of the present invention.
Drawings
An implant 1; an artificial tooth root 11; a base 12;
a crosslinking agent 3;
a functional molecule 4.
Detailed Description
To further understand the technical solution of the present invention, the following preferred embodiments are specifically illustrated in the following drawings, and the following detailed description is made in order to achieve the above objects and effects:
as shown in fig. 1, the present invention provides a method for preparing an implant structure, comprising the following steps:
step one 10: providing an implant finished product, wherein the implant comprises an artificial tooth root and a base arranged on the artificial tooth root;
step two 20: decomposing a monomer containing silicon oxygen molecules (Siloxane) into an ionic state (plasma), and forming a nano-coating on the surface of the implant;
step three 30: the surface of the implant is coated or dipped with a cross-linking agent, which is a Chemical cross-linking agent or a natural cross-linking agent or a combination thereof, and similar to the molecular adhesive, generates Chemical bonds (Chemical bonds) between molecules (molecules) to generate an adhesion effect, for example: genipin, procyanidine and the like, and when the cross-linking agent is contacted with the siloxane coating, covalent bond combination is generated, so that the cross-linking agent has the capacity of combining with other functional molecules;
step four 40: coating functional molecules outside the cross-linking agent to generate chemical bonds and keep the chemical bonds on the surface of the implant; the functional molecule can be a bone growth promoting molecule for shortening osseointegration time and shortening treatment course; or can be an antibacterial molecule for reducing the incidence of periphyton, thereby improving the success rate of the operation;
the implant structure is completed through the above steps.
Fig. 2 and fig. 3 show an implant structure according to the present invention, which includes:
an implant 1 for being embedded in an alveolar bone and supporting a dental prosthesis, comprising an artificial tooth root 11 and a base 12 provided on the artificial tooth root 11, wherein the artificial tooth root 11 is for being embedded in the alveolar bone, and the base 12 is for supporting the dental prosthesis;
a monomer 2 containing silicon oxygen molecules, which is coated on the surface of the implant 1, wherein the monomer 2 containing silicon oxygen molecules is coated on the surface of the implant 1 after being decomposed into an ion state;
a cross-linking agent 3 attached to or coated on or soaked in the surface of the plated implant 1, wherein the cross-linking agent 3 is a chemical cross-linking agent or a natural cross-linking agent or a combination thereof, such as: genipin or procyanidins;
the functional molecules 4 are coated outside the cross-linking agent 3 and generate chemical bonding, so that the functional molecules 4 are retained on the surface of the implant 1, and the functional molecules 4 are bone growth promoting molecules or antibacterial molecules.
Through the structure, the implant 1 of the present invention is cross-linked by the coating and the molecules, and provides the corresponding functions of the implant 1 according to different functional molecules 4, such as the bone growth promoting molecules for shortening the osseointegration time and shortening the treatment course, and the antibacterial molecules for reducing the incidence of peri-implantitis, thereby improving the success of the dental implant surgery.
The above detailed description is specific to one possible embodiment of the present invention, which is not intended to limit the scope of the invention, but rather is intended to include equivalent implementations or modifications without departing from the technical spirit of the invention.
Claims (10)
1. A method for preparing an implant structure, comprising the steps of:
step 1: providing a finished implant product;
step 2: decomposing a monomer containing silicon-oxygen molecules into an ion state, and forming a coating on the surface of the implant;
and step 3: attaching or coating or soaking a cross-linking agent capable of generating covalent bond combination with the siloxane coating on the surface of the implant;
and 4, step 4: coating functional molecules outside the cross-linking agent to generate chemical bonds and keep the chemical bonds on the surface of the implant.
2. A method of preparing a graft structure of claim 1, wherein said cross-linking agent is a chemical cross-linking agent or a natural cross-linking agent or a combination thereof and is a molecular adhesive.
3. A method of preparing a graft structure according to claim 1, wherein said cross-linking agent is genipin or procyanidin.
4. A method of preparing a graft structure of claim 1, wherein said functional molecule is a bone growth promoting molecule for reducing the period of osteointegration.
5. A method of preparing a graft structure of claim 1, wherein said functional molecule is an antibacterial molecule to reduce the incidence of peri-graft inflammation.
6. A graft structure produced by the method of claim 1, comprising:
the implant body comprises an artificial tooth root and a base arranged on the artificial tooth root;
coating a film on the surface of the implant by using a monomer containing a silica molecule;
the cross-linking agent is attached to the surface of the coated implant;
the functional molecule is attached to or coated on or soaked outside the cross-linking agent and generates chemical bonding, so that the functional molecule is kept on the surface of the implant.
7. A graft structure as claimed in claim 6, wherein said monomer containing a molecule of the siloxy type is decomposed into an ionic state and then coated on the surface of the graft.
8. A graft structure according to claim 6, wherein said cross-linking agent is a chemical cross-linking agent or a natural cross-linking agent or a combination thereof and is a molecular adhesive.
9. A graft structure as claimed in claim 6, wherein said functional molecule is a bone growth promoting molecule or an antibacterial molecule.
10. A graft structure according to claim 6, wherein said cross-linking agent is genipin or procyanidin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811068588.9A CN110893121A (en) | 2018-09-13 | 2018-09-13 | Implant structure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811068588.9A CN110893121A (en) | 2018-09-13 | 2018-09-13 | Implant structure and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110893121A true CN110893121A (en) | 2020-03-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811068588.9A Pending CN110893121A (en) | 2018-09-13 | 2018-09-13 | Implant structure and preparation method thereof |
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| CN (1) | CN110893121A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040002557A1 (en) * | 2002-06-21 | 2004-01-01 | Xuejun Qian | Silver-containing dental composition |
| US20060178444A1 (en) * | 1998-10-02 | 2006-08-10 | Jean-Marc Frances | Dental composition based on silicone crosslinkable by cation process |
| CN101006944A (en) * | 2007-01-31 | 2007-08-01 | 浙江大学 | A method for assembling RGD on the surface of porous pure titanium dental implant |
| FR2922434A1 (en) * | 2007-10-18 | 2009-04-24 | Rech S Et De Fabrication Serf | Dental implant i.e. artificial root, for prosthesis system, has part whose surface is coated with collagen film, where film is native collagen film having natural and/or reconstituted fibrillar structures when film is coated on implant |
| CN102958466A (en) * | 2010-06-25 | 2013-03-06 | 松下电器产业株式会社 | Molded body for dental cutting tool and method for producing same |
| CN106539627A (en) * | 2016-12-23 | 2017-03-29 | 大连三生科技发展有限公司 | A kind of tooth implant of the bioactivity surface containing RGD |
| CN106659639A (en) * | 2014-07-11 | 2017-05-10 | 三井化学株式会社 | Dental prosthesis |
| CN108057112A (en) * | 2018-02-05 | 2018-05-22 | 苏州工业园区方津口腔诊所有限公司 | A kind of middle liquid medicine and dental implant method for oral tooth implantation |
-
2018
- 2018-09-13 CN CN201811068588.9A patent/CN110893121A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060178444A1 (en) * | 1998-10-02 | 2006-08-10 | Jean-Marc Frances | Dental composition based on silicone crosslinkable by cation process |
| US20040002557A1 (en) * | 2002-06-21 | 2004-01-01 | Xuejun Qian | Silver-containing dental composition |
| CN101006944A (en) * | 2007-01-31 | 2007-08-01 | 浙江大学 | A method for assembling RGD on the surface of porous pure titanium dental implant |
| FR2922434A1 (en) * | 2007-10-18 | 2009-04-24 | Rech S Et De Fabrication Serf | Dental implant i.e. artificial root, for prosthesis system, has part whose surface is coated with collagen film, where film is native collagen film having natural and/or reconstituted fibrillar structures when film is coated on implant |
| CN102958466A (en) * | 2010-06-25 | 2013-03-06 | 松下电器产业株式会社 | Molded body for dental cutting tool and method for producing same |
| CN106659639A (en) * | 2014-07-11 | 2017-05-10 | 三井化学株式会社 | Dental prosthesis |
| CN106539627A (en) * | 2016-12-23 | 2017-03-29 | 大连三生科技发展有限公司 | A kind of tooth implant of the bioactivity surface containing RGD |
| CN108057112A (en) * | 2018-02-05 | 2018-05-22 | 苏州工业园区方津口腔诊所有限公司 | A kind of middle liquid medicine and dental implant method for oral tooth implantation |
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