CN108057075A - It is a kind of for vegetable oil composition of auxiliary treatment hyperplasia of prostate and preparation method thereof - Google Patents
It is a kind of for vegetable oil composition of auxiliary treatment hyperplasia of prostate and preparation method thereof Download PDFInfo
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- CN108057075A CN108057075A CN201610977943.9A CN201610977943A CN108057075A CN 108057075 A CN108057075 A CN 108057075A CN 201610977943 A CN201610977943 A CN 201610977943A CN 108057075 A CN108057075 A CN 108057075A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract
The invention belongs to field of health care products, are related to a kind of for vegetable oil composition of auxiliary treatment hyperplasia of prostate and preparation method thereof.Specifically, vegetable oil composition of the invention is made of following ingredients in parts by weight：10~20 parts of Angelica oils, 10~20 parts of tea leaf oils, 5~10 parts of eupatoria oils and 0.1~0.5 part of myrrh oil.It is proved by pharmacological evaluation, the vegetable oil composition for auxiliary treatment hyperplasia of prostate of the present invention can effectively alleviate the symptom of Patients with Prostatic Hyperplasia, and raw material is natural, non-stimulated, preparation method is simple and easy to do, it is suitable for exploitation into the auxiliary product for the treatment of hyperplasia of prostate, great market prospects.
Description
Technical field
The invention belongs to health product technology fields, are related to a kind of vegetable oil composition for auxiliary treatment hyperplasia of prostate
And preparation method thereof.
Background technology
Hyperplasia of prostate is one of middle-aging male common disease, and with the development of population in the world aging, prostate increases
Raw morbidity is increased.The incidence of hyperplasia of prostate is incremented by substantially as the age, but while having preneoplastic lesions not necessarily has
Clinical symptoms.The early stage of hyperplasia of prostate, Symptoms were not true to type due to compensatory, and as lower urinary tract obstruction aggravates, symptom is gradual
Substantially, clinical symptoms include urine storage phase symptom (frequent micturition, enuresis nocturna increase, urgent urination, the urinary incontinence), urinate phase symptom (dysuria, urine
Wait, dribbling), post micturition symptoms (urine retention, residual urine increase, the retention of urine) and other symptoms (blood urine, urinary tract infections,
Lithangiuria, renal impairment).
Include following several classes for the drug therapy of hyperplasia of prostate：(1) 5α-reductase inhibitor (such as Proscar)；
(2) alpha-blocking agent (such as hytrin)；(3) antiandrogen (such as progestational hormone drug and non steroidal antiandrogen fluorine he
Amine)；(4) other classifications (such as m receptor antagonist, galenical, Chinese medicine).However, long-term use of chemical synthetic drug can produce
Raw different degrees of side effect, wherein：The long-acting 1 receptor blocker Terazosin (trade names of α of selectivity：Hytrin) body can be caused
The malaise symptoms such as position property low blood pressure, dry, nasal obstruction, palpitating speed；5α-reductase inhibitor Finasteride (trade name：Protect row
Control) long-term use is needed, it is recurred rapidly after drug withdrawal；Antiandrogen flutamide (trade name：Flutamide) male's property can be made
Sign is degenerated, and breast presents womanlike.In comparison, it is relatively safe to take Chinese medicine preparation, there are few toxic side effect reports.
The content of the invention
For the above situation, it is an object of the invention to provide a kind of novel plants for auxiliary treatment hyperplasia of prostate
Fluid composition and preparation method thereof.
To achieve these goals, the present invention adopts the following technical scheme that：
A kind of vegetable oil composition for auxiliary treatment hyperplasia of prostate, by following ingredients group in parts by weight
Into：10~20 parts of Angelica oils, 10~20 parts of tea leaf oils, 5~10 parts of eupatoria oils and 0.1~0.5 part of myrrh oil.
Preferably, above-mentioned vegetable oil composition is made of following ingredients in parts by weight：12~18 parts of Angelica oils, 12~
18 parts of tea leaf oils, 6~9 parts of eupatoria oils and 0.2~0.4 part of myrrh oil.
It is furthermore preferred that above-mentioned vegetable oil composition is made of following ingredients in parts by weight：15 parts of Angelica oils, 15 parts of tea
Leaf oil, 8 parts of eupatoria oils and 0.3 part of myrrh oil.
When the root for being classified as Umbelliferae archangel Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels), main product in
The southeast of Gansu is secondly the provinces such as Yunnan, Sichuan, Shanxi, Hubei so that Minxian County yield is more, quality is high.Autumn Mo excavates, warm-natured, taste
Pungent, sweet, the thoughts of returning home, liver, the spleen channel for promoting blood circulation and stopping pain, tonifying blood and regulating menstruation, relax bowel.In Angelica oil rich in lactone (in such as Jehol Ligusticum Rhizome
Ester and Bdph) ingredient.
In above-mentioned vegetable oil composition, the Angelica oil is made using microwave radiation technology organic solvent extraction, specific mistake
Journey is as follows：It is crushed after Radix Angelicae Sinensis is cleaned, crosses 30~80 mesh sieves, obtain angelica powder；According to angelica powder:Hexamethylene=1g:2~5mL
Dosage, angelica powder is added in hexamethylene, power under the conditions of 600~800W in room temperature Microwave Extraction 1~3 minute；
Residue is filtered out after extraction, filtrate decompression is concentrated into solvent-free taste, obtains Angelica oil.
In above-mentioned vegetable oil composition, the weight percent of Ligustilide is more than 40% in the Angelica oil.
Tealeaves is the bud or tender leaf of Theaceae Camellia Plants tea (Camellia sinensis (L.) O.Kuntze), wild
Non-hibernating eggs is all over the mountain area for seeing drought each province.Cold nature, sweet in flavor, bitter, nontoxic, the thoughts of returning home, lung, stomach disappear for heat-clearing
Food, diuresis convergence, stop dysentery removing toxic substances.Contain in tea leaf oil there are many small molecule ethers (such as anethole) and monoterpene alcohols (such as fragrant camphor tree
Alcohol) ingredient.
In above-mentioned vegetable oil composition, the tea leaf oil is made using organic solvent ultrasonic extraction, and detailed process is such as
Under：It is crushed after tealeaves is cleaned, crosses 30~80 mesh sieves, obtain tea leaf powder；According to tea leaf powder:Ether=1g:The use of 5~10mL
Amount, tea leaf powder was added in ether, in room temperature ultrasonic extraction 10~30 minutes；Residue, filtrate warp are filtered out after extraction
Solvent-free taste is concentrated under reduced pressure into after activated carbon decolorizing, obtains tea leaf oil.
In above-mentioned vegetable oil composition, the weight percent of anethole is more than 30% in the tea leaf oil, linalool
Weight percent be more than 5%.
Herba Lycopi is Labiatae bamboo shoot platymiscium lycopus lucidus (Lycopus lucidus Turcz.) or hair leaf lycopus lucidus
The aerial part of (Lycopus lucidus Turcz.var.hirtus Regel), is distributed in Liaoning, the Inner Mongol, Hebei, river
The provinces such as Soviet Union, Zhejiang.Summer, two season of autumn cauline leaf it is luxuriant when tap, slightly warm in nature, acrid flavour, hardship, Return liver, the spleen channel for promoting blood circulation for regulating menstruation, are dispelled
Stagnation resolvation carbuncle, inducing diuresis for removing edema.Alkenes (such as nopinene and carypohyllene) ingredient there are many containing in eupatoria oil.
In above-mentioned vegetable oil composition, the eupatoria oil is made using organic solvent ultrasonic extraction, and detailed process is such as
Under：It is crushed after Herba Lycopi is cleaned, crosses 30~80 mesh sieves, obtain Herba Lycopi powder；According to Herba Lycopi powder:Acetone=1g:The dosage of 3~8mL,
Herba Lycopi powder is added in acetone, in room temperature ultrasonic extraction 10~30 minutes；Residue is filtered out after extraction, filtrate decompression is dense
Solvent-free taste is reduced to, obtains eupatoria oil.
In above-mentioned vegetable oil composition, the weight percent of nopinene is more than 30% in the eupatoria oil, carypohyllene
Weight percent is more than 10%.
Myrrh is Burseraceae myrrh platymiscium Chinese violet tree (Commiphora myrrha Engl.) or Ha Didingshu
(Commiphora molmol Engl.) stem skin zone exudation oleo-gum-resin, originate in Somalia, Ethiopia and Ah
Draw the ground such as primary peninsula south.Tree is stabbed between annual 2 months November to next years, resin is oozed out naturally by wound or crack mouth, is just
Yellowish white liquid, fades to rufous lump, mild-natured, bitter in air, and the thoughts of returning home, liver, the spleen channel for promoting blood circulation and stopping pain, disappear
Swollen myogenic.Contain abundant sesquiterpenoids (such as myrrh ketone, epicurzerenone and curzerenone) ingredient in myrrh oil.
In above-mentioned vegetable oil composition, the myrrh oil is made using organic solvent reflux extraction, and detailed process is such as
Under：Myrrh is crushed, obtains not having medicinal powder；According to not having medicinal powder:Ethyl acetate=1g:The dosage of 10~20mL will there be medicinal powder addition
Into ethyl acetate, when refluxing extraction 0.5~2 is small；Residue is filtered out after extraction, filtrate decompression is concentrated into solvent-free taste,
Obtain myrrh oil.
In above-mentioned vegetable oil composition, the weight percent of myrrh ketone is more than 10% in the myrrh oil, epicurzerenone
Weight percent be more than 5%.
A kind of preparation method of vegetable oil composition for auxiliary treatment hyperplasia of prostate, includes the following steps：It will
Angelica oil, tea leaf oil, eupatoria oil and the myrrh oil mixing of formula ratio, are stirred at room temperature uniformly, obtain for auxiliary treatment forefront
The vegetable oil composition of gland hyperplasia.
In above-mentioned preparation method, the stirring is completed by mechanically or magnetically power agitating device.
The application method of the above-mentioned vegetable oil composition for auxiliary treatment hyperplasia of prostate is as follows：Take 1mL or so daily
Vegetable oil composition is placed in the centre of the palm, is with the hands smeared uniformly after being mixed with isometric olive oil, is subsequently placed at lower abdomen, draws a circle
Massage is allowed to fully absorb for 5~10 minutes, each 1 time daily morning and evening, is used continuously 6 months.In addition, the present invention's controls for auxiliary
The vegetable oil composition for treating hyperplasia of prostate also can be by being administered orally：1mL or so vegetable oil compositions are taken, after waking up daily and are slept
It is preceding respectively to take 1 time, it is used continuously 3~6 months.
It is proved by pharmacological evaluation, the vegetable oil composition for auxiliary treatment hyperplasia of prostate of the invention can be effective
Alleviate the symptom of Patients with Prostatic Hyperplasia, and raw material is natural, non-stimulated, and preparation method is simple and easy to do, is suitable for exploitation into controlling
Treat the auxiliary product of hyperplasia of prostate, great market prospects.
Specific embodiment
Technical scheme is made below in conjunction with specific embodiment further elucidated above.The following example is only used
In the explanation and illustration present invention, and should not be taken as limiting the scope of the invention.Unless otherwise stated, institute in the following example
Instrument, reagent, material for using etc. can be obtained by routine business means.
Embodiment 1：The preparation of Angelica oil.
Dry, crushing after 1kg Dingxi, Gansus production Radix Angelicae Sinensis is eluted with water, crosses 50 mesh sieves, obtains angelica powder, be then added to
In 4L hexamethylenes, Microwave Extraction machine (power 700W) is used in room temperature Microwave Extraction 2min.Residue is filtered out after extraction,
Filtrate is placed in Rotary Evaporators and is concentrated under reduced pressure into solvent-free taste, obtains the Angelica oil (content of about 9.8g, wherein Ligustilide
For 45.2wt%).
Embodiment 2：The preparation of tea leaf oil.
Dry, crushing, crosses 50 mesh sieves, obtains tea leaf powder, Ran Houjia after 1kg Zhejiang Hangzhous production fresh tea leaf is eluted with water
Enter into 8L ether, use ultrasonic extractor (frequency 30kHz) in room temperature ultrasonic extraction 20min.It is filtered after extraction
Fall residue, filtrate is placed in Rotary Evaporators through activated carbon decolorizing and is concentrated under reduced pressure into solvent-free taste, obtains tea leaf oil (about
The content of 8.2g, wherein anethole are 32.1wt%, and the content of linalool is 5.5wt%).
Embodiment 3：The preparation of eupatoria oil.
Dry, crushing after 1kg Hebei Jizhou City production Herba Lycopi is eluted with water, crosses 50 mesh sieves, obtains Herba Lycopi powder, be then added to
In 5L acetone, ultrasonic extractor (frequency 30kHz) is used in room temperature ultrasonic extraction 20min.It is filtered out after extraction residual
Filtrate is placed in Rotary Evaporators and is concentrated under reduced pressure into solvent-free taste by slag, and obtaining eupatoria oil, (about 7.4g's, wherein nopinene contains
It measures as 33.3wt%, the content of carypohyllene is 11.3wt%).
Embodiment 4：The preparation of myrrh oil.
100g myrrhs are crushed, obtain not having medicinal powder, are then added in 1.5L ethyl acetate, are added under mechanical agitation
Heat to flow back, extract 1h, filter out residue after extraction, filtrate is placed in Rotary Evaporators be concentrated under reduced pressure into it is solvent-free
Taste obtains myrrh oil (about 6.7g, the wherein content of myrrh ketone are 12.2wt%, and the content of epicurzerenone is 6.7wt%).
Embodiment 5- embodiments 9：For the preparation of the vegetable oil composition of auxiliary treatment hyperplasia of prostate.
The vegetable oil composition for auxiliary treatment hyperplasia of prostate is prepared according to the formula in table 1, preparation process is such as
Under：Angelica oil, tea leaf oil, eupatoria oil and myrrh oil are mixed, is stirred evenly, is used for using mechanical stirring device in room temperature
The vegetable oil composition of auxiliary treatment hyperplasia of prostate.
Table 1. is used for the prescription and dosage of the vegetable oil composition of auxiliary treatment hyperplasia of prostate
According to the test method in the People's Republic of China's standard GB/T/T26516-2011 massage essential oils to above-mentioned use
It is detected in the vegetable oil composition of auxiliary treatment hyperplasia of prostate, the results are shown in Table 2.As shown in Table 2, it is of the invention
Meet standard requirement for the vegetable oil composition of auxiliary treatment hyperplasia of prostate, possess development prospect.
Table 2. is used for the Testing index result of the vegetable oil composition of auxiliary treatment hyperplasia of prostate
Experimental example：For the effect experiment of the vegetable oil composition of auxiliary treatment hyperplasia of prostate.
60 people of male (average age 62.5 years old) made a definite diagnosis with hyperplasia of prostate for 60~70 years old is selected, is randomly divided into 6 groups,
Every group of 10 people are respectively 9 groups of blank control group, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment and embodiment.
Treatment group takes 1mL or so vegetable oil compositions to be placed in the centre of the palm, with the hands smears uniformly after being mixed with isometric olive oil, then puts
At lower abdomen, massage of drawing a circle is allowed to fully absorb for 5~10 minutes, each 1 time daily morning and evening, is used continuously 6 months, blank control group
It using only olive oil, is equally carried out continuously 6 months, record vegetable oil composition is waited using front and rear dysuria, urine, dribbling
Etc. symptoms, the results are shown in Table 3.
3. vegetable oil composition of table treats the effect of hyperplasia of prostate
| Group | Symptom disappearance number of cases | Symptom mitigates number of cases | Invalid number of cases |
| Blank control group | 0 | 3 | 7 |
| 5 groups of embodiment | 2 | 7 | 1 |
| 6 groups of embodiment | 1 | 8 | 1 |
| 7 groups of embodiment | 2 | 6 | 2 |
| 8 groups of embodiment | 2 | 7 | 1 |
| 9 groups of embodiment | 3 | 6 | 1 |
As seen from the above table, by the treatment of 6 months, the elderly with hyperplasia of prostate is using the vegetable oil of the present invention
After composition, the symptoms such as dysuria, urine wait, dribbling are effectively improved, and the symptom of most subjects obtains
Alleviate, even disappear completely, compared with the control group significant effect.In addition, by the continuous use of 6 months, treatment group patient is simultaneously
Not reflecting has any discomfort symptom, shows the vegetable oil composition of the present invention and has certain security, can be safe to use.
Claims (9)
1. a kind of vegetable oil composition for auxiliary treatment hyperplasia of prostate is made of following ingredients in parts by weight：
10~20 parts of Angelica oils, 10~20 parts of tea leaf oils, 5~10 parts of eupatoria oils and 0.1~0.5 part of myrrh oil.
2. the vegetable oil composition according to claim 1 for auxiliary treatment hyperplasia of prostate, it is characterised in that：
The vegetable oil composition is made of following ingredients in parts by weight：12~18 parts of Angelica oils, 12~18 parts of tea leaf oils,
6~9 parts of eupatoria oils and 0.2~0.4 part of myrrh oil.
3. the vegetable oil composition according to claim 1 for auxiliary treatment hyperplasia of prostate, it is characterised in that：
The vegetable oil composition is made of following ingredients in parts by weight：15 parts of Angelica oils, 15 parts of tea leaf oils, 8 parts of Herba Lycopi
Oil and 0.3 part of myrrh oil.
4. the vegetable oil composition according to any one of claim 1 to 3 for auxiliary treatment hyperplasia of prostate, special
Sign is：
The weight percent of Ligustilide is more than 40% in the Angelica oil.
5. the vegetable oil composition according to any one of claim 1 to 3 for auxiliary treatment hyperplasia of prostate, special
Sign is：
The weight percent of anethole is more than 30% in the tea leaf oil, and the weight percent of linalool is more than 5%.
6. the vegetable oil composition according to any one of claim 1 to 3 for auxiliary treatment hyperplasia of prostate, special
Sign is：
The weight percent of nopinene is more than 30% in the eupatoria oil, and the weight percent of carypohyllene is more than 10%.
7. the vegetable oil composition according to any one of claim 1 to 3 for auxiliary treatment hyperplasia of prostate, special
Sign is：
The weight percent of myrrh ketone is more than 10% in the myrrh oil, and the weight percent of epicurzerenone is more than 5%.
8. a kind of vegetable oil composition according to any one of claim 1 to 7 for auxiliary treatment hyperplasia of prostate
Preparation method, include the following steps：The Angelica oil of formula ratio, tea leaf oil, eupatoria oil and myrrh oil are mixed, stirred in room temperature
It mixes uniformly, obtains for the vegetable oil composition of auxiliary treatment hyperplasia of prostate.
9. preparation method according to claim 8, it is characterised in that：
The stirring is completed by mechanically or magnetically power agitating device.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742903A (en) * | 2005-09-29 | 2006-03-08 | 济南宏济堂制药有限责任公司 | Medicine for treating prostatitis and hyperlasia of prostate |
| CN103845689A (en) * | 2012-12-06 | 2014-06-11 | 中牟县增寿堂诊所 | External application medicine for treating benign prostatic hyperplasia |
| CN106139030A (en) * | 2016-08-16 | 2016-11-23 | 黄绍华 | A kind of Chinese medicine for treating prostatic hyperplasia |
-
2016
- 2016-11-08 CN CN201610977943.9A patent/CN108057075A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742903A (en) * | 2005-09-29 | 2006-03-08 | 济南宏济堂制药有限责任公司 | Medicine for treating prostatitis and hyperlasia of prostate |
| CN103845689A (en) * | 2012-12-06 | 2014-06-11 | 中牟县增寿堂诊所 | External application medicine for treating benign prostatic hyperplasia |
| CN106139030A (en) * | 2016-08-16 | 2016-11-23 | 黄绍华 | A kind of Chinese medicine for treating prostatic hyperplasia |
Non-Patent Citations (2)
| Title |
|---|
| 杨晶等: ""当归挥发油蒿苯内酯对大鼠前列腺增生前列腺组织TGF_1表达的影响"", 《中国医药指南》 * |
| 杨继红编著: "《无痛刮痧》", 30 April 2011, 山西科学技术出版社 * |
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