CN108057061A - A kind of anti-acne and relieving itching and eliminating swelling composition and preparation method thereof - Google Patents

A kind of anti-acne and relieving itching and eliminating swelling composition and preparation method thereof Download PDF

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CN108057061A
CN108057061A CN201810074152.4A CN201810074152A CN108057061A CN 108057061 A CN108057061 A CN 108057061A CN 201810074152 A CN201810074152 A CN 201810074152A CN 108057061 A CN108057061 A CN 108057061A
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dandelion
kuh
seng
composition
honeysuckle
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CN108057061B (en
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林山
伍明
李建惠
林·斯蒂文
黄莉媖
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Wuhan Ganwu Technology Co ltd
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CHENGDU SHANXIN PHARMACEUTICAL Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K2236/30—Extraction of the material
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of anti-acne and relieving itching and eliminating swelling composition and preparation method thereof, the composition includes honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae, wherein, by quality ratio, the honeysuckle：Dandelion：Kuh-seng：Radix Salviae Miltiorrhizae=1.5：1.5：1：1.The composition of the present invention has good compatibility with skin, it can significantly removing acne, with can be absorbed by the skin rapidly, safety does not stimulate, not allergy, after the composition 4 weeks with acne-removing of the present invention, skin recovers smooth, and acne is uneasy to recur after disabling, and safely and effectively and effect is lasting.The composition gels agent of the present invention can be used for the relieving itching and eliminating swelling after bite by mosquitos, Quick itch stopping in 10 minutes, and 2 interior detumescences when small are quick, safe and reliable.

Description

A kind of anti-acne and relieving itching and eliminating swelling composition and preparation method thereof
Technical field
The invention belongs to biomedicine technical fields, and in particular to a kind of anti-acne and relieving itching and eliminating swelling composition and its preparation Method.
Background technology
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, teenager is mainly apt to occur in, to teenager Psychology and social influence it is very big, patient is made the negative emotions such as not self-confident, awkward, nervous, anxiety, depression occur, so as to influence Quality of life.With the characteristics of the pleomorphism skin lesions such as acne, papule, warts, tubercle of the acne clinical manifestation to be apt to occur in face, even companion With pruitus.It is mainly treated currently on the market with chemical bactericide, antibiotic and hormonal substance, long-time service has skin Irritation, side effect are big.
Mosquito is the insect of a kind of very little type, and species is various, they stab skin and suck blood, and has both influenced people's rest, may be used also The infectious diseases such as encephalitis, malaria are propagated, the skin bitten can become red and swollen, feel violent itch.Under normal circumstances, useful soap or Partial smearing mitigates symptom after sodium bicarbonate dilution, but effect is not ideal, is extremely difficult to the effect of rapid relieving itching and eliminating swelling.For mosquito Relieving itching and eliminating swelling after sting, mainly essential wind oil, the antipruritic agent of refrigerant oils currently on the market, containing alcoholic content, no Be suitble to the crowd of skin sensitivity, as hormone medicine, antipruritic effect clearly, but the special populations such as pregnant woman children need it is careful With.
The content of the invention
The purpose of this part is to summarize some aspects of the embodiment of the present invention and briefly introduce some preferably to implement Example.It may do in this section and the description of the application and the title of the invention a little simplified or omit to make our department Point, the purpose of abstract of description and denomination of invention obscure, and this simplification or omit and cannot be used for limiting the scope of the invention.
In view of the defects of anti-acne of the prior art and relieving itching and eliminating swelling composition and preparation method thereof, it is proposed that this hair It is bright.
Therefore, as one aspect of the present invention, to overcome the deficiencies of the prior art and provide a kind of anti-acne and antipruritic disappearing Swollen composition.
In order to solve the above technical problems, the present invention provides following technical solutions：A kind of anti-acne and relieving itching and eliminating swelling combination Object, wherein, the anti-acne compsn includes honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae, by quality ratio, the honeysuckle： Dandelion：Kuh-seng：Radix Salviae Miltiorrhizae=1.5：1.5：1：1.
As anti-acne of the present invention and a kind of preferred embodiment of relieving itching and eliminating swelling composition, wherein, the composition Card ripple, glycerine, 1,3-BDO, triethanolamine, menthol are further included, by percentage to the quality, the card ripple content is 0.5%~1.5%, the glycerol content is 4%~6%, the 1,3 butylene glycol content is 1%~3%, the triethanolamine Content is 0.5%~2%, institute's menthol content is 0.4%~0.6%, and surplus is water.
As anti-acne of the present invention and a kind of preferred embodiment of relieving itching and eliminating swelling composition, wherein, the composition Component be respectively by percentage to the quality：The honeysuckle content is 3%, the dandelion content is 3%, the kuh-seng contains It is 2% to measure as 2%, the Radix Salviae Miltiorrhizae content, the card ripple content is 1%, the glycerol content is 5%, the 1,3 butylene glycol Content is 2%, the triethanolamine content is 1%, institute's menthol content is 0.5%, and surplus is water.
As another aspect of the present invention, to overcome the deficiencies of the prior art and provide a kind of anti-acne and relieving itching and eliminating swelling The preparation method of composition.
In order to solve the above technical problems, the present invention provides following technical solutions：A kind of anti-acne and relieving itching and eliminating swelling combination The preparation method of object, it is characterised in that：Including extraction：Dandelion, kuh-seng, Radix Salviae Miltiorrhizae are crushed；By honeysuckle, dandelion, hardship Ginseng, Radix Salviae Miltiorrhizae are soaked, heating extraction, and filtering obtains extracting solution；The extracting solution is concentrated, is cooled down to get extract；It prepares： Card ripple soaked overnight, heats and stirs；Add in glycerine, stirring；Add in 1,3-BDO, stirring；Add in the extracted gold Honeysuckle flower, dandelion, kuh-seng, Salvia root P.E, stirring；Add in menthol, stirring；Triethanolamine is added in, stirring forms gel.
As a kind of preferred embodiment of the preparation method of anti-acne of the present invention and relieving itching and eliminating swelling composition, wherein, institute Extraction is stated, it is described to crush dandelion, kuh-seng, Radix Salviae Miltiorrhizae, it is that the dandelion, kuh-seng, Radix Salviae Miltiorrhizae are crushed to below 2.0cm；Institute It states and soaks, be that the honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae are added in mass ratio is 5~15 times of water, during the immersion Between be 12h；The heating extraction, temperature are 70~90 DEG C, and the time is 0.5~2h；It is described to concentrate the extracting solution, it is described dense Contracting temperature is 60 DEG C；The cooling is cooled to temperature as 35~45 DEG C.
As a kind of preferred embodiment of the preparation method of anti-acne of the present invention and relieving itching and eliminating swelling composition, wherein, institute Extraction is stated, it is described to soak, it is that the honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae are added in into the water that mass ratio is 10 times, it is described Heating extraction, temperature are 80 DEG C, time 1h；Described to concentrate the extracting solution, the thickening temperature is 60 DEG C, is concentrated into material Liquor ratio is 1:1.25, unit g:ml.
As a kind of preferred embodiment of the preparation method of anti-acne of the present invention and relieving itching and eliminating swelling composition, wherein, institute Preparation is stated, the card ripple soaked overnight is heated and stirred, 40 DEG C of the heating temperature, and the mixing time is 2h；The addition Glycerine, stirring, time 0.5h；The addition 1,3-BDO, stirring, time 0.5h；The extracted honeysuckle of the addition, Dandelion, kuh-seng, Salvia root P.E, stirring, time 0.5h；The addition menthol, stirring, to add in 80~120 purposes Menthol, the mixing time are 1h；The addition triethanolamine, stirring form gel, time 1h.
As a kind of preferred embodiment of the preparation method of anti-acne of the present invention and relieving itching and eliminating swelling composition, wherein, institute Preparation is stated, by percentage to the quality, the card ripple addition is 1%, the glycerine input is 5%, the 1,3-BDO Addition is 2%, the triethanolamine addition is 1%, the honeysuckle addition is 3%, the dandelion addition is 3%th, the kuh-seng addition is 2%, the Radix Salviae Miltiorrhizae addition is 2%, institute's menthol addition is 0.5%, and surplus is water.
As a kind of preferred embodiment of the preparation method of anti-acne of the present invention and relieving itching and eliminating swelling composition, wherein, institute Preparation is stated, the speed of the stirring is 150r/min, the addition menthol, to add in the menthol of 100 mesh.
Beneficial effects of the present invention：In the present composition, honeysuckle and dandelion are mainly clearing heat and detoxicating, dispersing swelling and dissipating binds, Radix Salviae Miltiorrhizae cool blood to disappear carbuncle, kuh-seng solve pruitus, and honeysuckle of the present invention, dandelion, kuh-seng, Radix Salviae Miltiorrhizae are prepared with specific proportioning, respectively It is irreplaceable between component, and act synergistically with card ripple, glycerine, 1,3-BDO, triethanolamine, menthol, with said composition For remarkable efficacy of the composition with relieving itching and eliminating swelling, anti-acne of main composition.The present composition stops anti-acne, anti-inflammatory Itch evident in efficacy, cure rate is high, the toxic side effect of no steroids.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, with reference to specific embodiment pair The specific embodiment of the present invention is described in detail.
Many details are elaborated in the following description to facilitate a thorough understanding of the present invention, still the present invention can be with Implemented using other different from other manner described here, those skilled in the art can be without prejudice to intension of the present invention In the case of do similar popularization, therefore the present invention is from the limitation of following public specific embodiment.
Secondly, " one embodiment " or " embodiment " referred to herein refers to may be included at least one realization side of the present invention A particular feature, structure, or characteristic in formula." in one embodiment " that different places occur in the present specification not refers both to Same embodiment, nor the individual or selective embodiment mutually exclusive with other embodiment.
Embodiment 1：
Honeysuckle, the extraction process screening of dandelion, kuh-seng, Salvia root P.E：
Honegsukle flower P.E extracting method：Traditional Chinese medicine honeysuckle plus 5~15 times of water are impregnated into 12h；70~90 DEG C of extraction medicinal materials 0.5~2h of mixture, filtering, obtains extracting solution；Extracting solution is concentrated into 1 for 60 DEG C:1.25(g:Ml), 35~45 DEG C are cooled to, is obtained Honegsukle flower P.E.
Dandelion extract extracting method：By dandelion pulverizing medicinal materials to below 2.0cm, 5~15 times of water is added to impregnate 12h； 70~90 DEG C of extraction 0.5~2h of medicinal material mixture, filtering obtain extracting solution；Extracting solution is concentrated into 1 for 60 DEG C:1.25(g:Ml), it is cold But to 35~45 DEG C, dandelion extract is obtained.
Shrubby sophora extract extracting method：By dandelion pulverizing medicinal materials to below 2.0cm, 5~15 times of water is added to impregnate 12h；70 ~90 DEG C of extraction 0.5~2h of medicinal material mixture, filtering obtain extracting solution；Extracting solution is concentrated into 1 for 60 DEG C:1.25(g:Ml), cool down To 35~45 DEG C, shrubby sophora extract is obtained.
Salvia root P.E extracting method：By dandelion pulverizing medicinal materials to below 2.0cm, 5~15 times of water is added to impregnate 12h；70 ~90 DEG C of extraction 0.5~2h of medicinal material mixture, filtering obtain extracting solution；Extracting solution is concentrated into 1 for 60 DEG C:1.25(g:Ml), cool down To 35~45 DEG C, Salvia root P.E is obtained.
Chlorogenic acid is a kind of important bioactive substance, has wide antibacterial, antivirus action and honeysuckle Main antibacterial, antiviral effective pharmaceutical component.Caffeic acid has extensive antibacterial, antiviral, detoxication, phenol in dandelion Acid compounds are mainly with caffeic acid and chlorogenic acid content be higher and the main component of dandelion antibacterial.Matrine is kuh-seng The general designation of all alkaloids, main component has a variety of alkaloids such as matrine, sophocarpine, N-Oxysophocarpine, Sophoridine, with hardship Join alkali, oxymatrine concentration highest, there is heat-clearing, desinsection, clearing damp.Tanshinone IIA has anti-infectious function, is used for Some skin diseases and acne are treated, is one of Radix Salviae Miltiorrhizae antibiotic effective ingredient.Honegsukle flower P.E of the present invention using chlorogenic acid content as Index, dandelion extract using coffee acid content as index, shrubby sophora extract using matrine and oxymatrine concentration as index, Radix Salviae Miltiorrhizae is detected extract quality using tanshinone IIA content as index.
Detection method：
Chlorogenic acid：HPLC methods use octadecylsilane chemically bonded silica as filler, with -0.4% phosphoric acid solution of acetonitrile (13: 87) it is mobile phase, Detection wavelength 327nm.Theoretical cam curve is calculated by chlorogenic acid peak should be not less than 1000.
Caffeic acid：HPLC methods use octadecylsilane chemically bonded silica as filler, with methanol-phosphate buffer (23 : it is 77) mobile phase, Detection wavelength 323nm；40 DEG C of column temperature.Theoretical cam curve is calculated by caffeic acid peak should be not less than 3000.
Matrine and oxymatrine：HPLC methods use amino bonded silica gel as filler, with acetonitrile-absolute ethyl alcohol- 3% phosphoric acid solution (80: 10: 10) be mobile phase, Detection wavelength 220nm.Theoretical cam curve should not by the calculating of oxymatrine peak Less than 2000.
Tanshinone IIA：HPLC methods use octadecylsilane chemically bonded silica as filler, are with methanol-water (75: 25) Mobile phase, Detection wavelength 270nm.Theoretical cam curve is calculated by tanshinone IIA peak should be not less than 2000.
Respectively to honeysuckle, dandelion, kuh-seng, the solid-liquid ratio of Radix Salviae Miltiorrhizae extraction, Extracting temperature, extraction time in extracting method Single factor experiment screening is carried out, as a result as shown in the following table 1,2,3,4：
1 honeysuckle extracting method of table is screened
Sequence number Solid-liquid ratio Extracting temperature (DEG C) Extraction time (h) Chlorogenic acid content
TQ-J-1 1：5 70 0.5 1.53%
TQ-J-2 1：10 70 0.5 1.68%
TQ-J-3 1：15 70 0.5 1.63%
TQ-J-4 1：10 80 0.5 1.77%
TQ-J-5 1：10 90 0.5 1.79%
TQ-J-6 1：10 80 1.0 1.84%
TQ-J-7 1：10 80 2.0 1.79%
As known from Table 1, the extraction solid-liquid ratio of honeysuckle is 1：10th, extracted when Extracting temperature is 80 DEG C, extraction time is 1h Chlorogenic acid content highest in object.
2 dandelion extracting method of table is screened
Sequence number Solid-liquid ratio Extracting temperature (DEG C) Extraction time (h) Coffee acid content
TQ-P-1 1：5 70 0.5 0.021%
TQ-P-2 1：10 70 0.5 0.025%
TQ-P-3 1：15 70 0.5 0.025%
TQ-P-4 1：10 80 0.5 0.028%
TQ-P-5 1：10 90 0.5 0.029%
TQ-P-6 1：10 80 1.0 0.031%
TQ-P-7 1：10 80 2.0 0.030%
As known from Table 2, the extraction solid-liquid ratio of dandelion is 1：10th, extracted when Extracting temperature is 80 DEG C, extraction time is 1h Coffee acid content highest in object.
3 kuh-seng extracting method of table is screened
Sequence number Solid-liquid ratio Extracting temperature (DEG C) Extraction time (h) Matrine and oxymatrine concentration
TQ-K-1 1：5 70 0.5 1.20%
TQ-K-2 1：10 70 0.5 1.42%
TQ-K-3 1：15 70 0.5 1.48%
TQ-K-4 1：10 80 0.5 1.60%
TQ-K-5 1：10 90 0.5 1.68%
TQ-K-6 1：10 80 1.0 1.69%
TQ-K-7 1：10 80 2.0 1.68%
As known from Table 3, the extraction solid-liquid ratio of kuh-seng is 1：10th, extract when Extracting temperature is 80 DEG C, extraction time is 1h In matrine and oxymatrine concentration highest.
4 Radix Salviae Miltiorrhizae extracting method of table is screened
Sequence number Solid-liquid ratio Extracting temperature (DEG C) Extraction time (h) Tanshinone IIA content
TQ-D-1 1：5 70 0.5 0.21%
TQ-D-2 1：10 70 0.5 0.23%
TQ-D-3 1：15 70 0.5 0.24%
TQ-D-4 1：10 80 0.5 0.27%
TQ-D-5 1：10 90 0.5 0.28%
TQ-D-6 1：10 80 1.0 0.29%
TQ-D-7 1：10 80 2.0 0.29%
As known from Table 4, the extraction solid-liquid ratio of Radix Salviae Miltiorrhizae is 1：10th, extract when Extracting temperature is 80 DEG C, extraction time is 1h In tanshinone IIA content highest.
Summary is as a result, selected honeysuckle, dandelion, kuh-seng, the extraction solid-liquid ratio of Radix Salviae Miltiorrhizae are 1：10th, Extracting temperature It it is 80 DEG C, extraction time is 1h.
Honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae extraction process are：By dandelion, kuh-seng, Radix Salviae Miltiorrhizae be crushed to 2.0cm with Under, 10 times of water is added to impregnate 12h honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae；80 DEG C of extraction medicinal material mixture 1h, filtering must extract Liquid；Extracting solution is concentrated into 1 for 60 DEG C:1.25(g:Ml), 35~45 DEG C are cooled to get extract.
Embodiment 2：
The preparation method of anti-acne and relieving itching and eliminating swelling composition：Card ripple soaked overnight, 40 DEG C of heating, stirs 2h；It adds in sweet Oil stirs 0.5h；1,3-BDO is added in, stirs 0.5h；Add in extracted honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae extraction Object stirs 0.5h；80~120 mesh sieve menthols are added in, stir 1h；Triethanolamine is added in, stirring 1h forms gel.Supply water extremely 1000g is to get composition.
The selection of different anti-acnes and relieving itching and eliminating swelling composition：
The formula of the different anti-acnes of table 5 and relieving itching and eliminating swelling composition
Light, moderate face acne vulgaris volunteer totally 135 people is chosen, wherein male 68 people, 67 people of female；Age 16-35 Sui puts down Equal 24.7 years old；Suffer from journey -6 years 4 weeks, average 2.8 years, 2 weeks before sample is smeared, be not used glucocorticosteroid hormone, tretinoin and Antibiotics, no hyperlipidemia and hepatic and renal function are abnormal, forbid indulging in excessive drinking, avoid sunburst or ultraviolet light excessive radiation.
135 volunteers are randomly divided into 15 groups, every group of 9 people.Subject cleans pars affecta skin and after drying with warm water, often Early, evening smears correspond to composition 1 time respectively, disables other drugs or cosmetics during use, judges curative effect after 4 weeks.It is treating Preceding and treatment the 4th week, it is total to volunteer's face inflammatory damage sum (summation of inflamed papules and warts), non-inflammatory lesions respectively Number (summation of Whiteheads and blackhead) counts, while the adverse reaction in detail after record use.Criterion：Base is cured： Therapeutic index >=90%；It is effective：60%≤therapeutic index ＜ 90%；Progress：20%≤therapeutic index ＜ 60%；It is invalid：Curative effect Index ＜ 20%.Total skin lesion number × 100% before therapeutic index=(total skin lesion number after total skin lesion number-treatment before treatment)/treatment.Have Efficiency=(base is cured number of cases+effective number of cases)/whole number of cases × 100%.
It is as shown in table 6 to the therapeutic effect of acne after 4 weeks：
The therapeutic effect of 6 different formulations composition of table
Found out by table 5-6, in composition, honeysuckle, dandelion, kuh-seng, Salvia root P.E play main anti-inflammatory anti-acne and make With, and 4 kinds of honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae extract combination using effects are more preferable.
Embodiment 3：
A kind of in honeysuckle, dandelion, kuh-seng, Salvia root P.E is replaced with into the similary Huang with heat-clearing toxin-expelling functions A kind of reed mentioned in ancient books or purslane extract (the same Honegsukle flower P.E of extraction process), result of study is as follows.
10g cards ripple adds in soaked overnight in 700g water, and 2h is stirred in 40 DEG C of heating；50g glycerine is added in, stirs 0.5h；It adds in The 1,3-BDO of 20g stirs 0.5h；Add in 4 in honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae, radix scutellariae, purslane extract Kind, stir 0.5h；The menthol 5g of 80~120 mesh sieves was added in, stirs 1h；10g triethanolamines are added in, stirring 1h forms solidifying Glue.Water is supplied to 1000g to get composition.
The different of 7 composition of table substitute recipe determination
The different therapeutic effects for substituting formula of 8 composition of table
Found out by table 7-8, in composition, honeysuckle, dandelion, kuh-seng, 4 kinds of Radix Salviae Miltiorrhizae extraction species it is a kind of by radix scutellariae or After purslane extract substitution, using effect is applied in combination not as good as honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae 4 kinds of extracts.
Embodiment 4：
10g cards ripple adds in soaked overnight in 700g water, and 2h is stirred in 40 DEG C of heating；50g glycerine is added in, stirs 0.5h；It adds in The 1,3-BDO of 20g stirs 0.5h；The honeysuckle of addition different quality percentage, dandelion, kuh-seng, Salvia root P.E, are stirred Mix 0.5h；The menthol 5g of 80~120 mesh sieves was added in, stirs 1h；10g triethanolamines are added in, stirring 1h forms gel.It supplies Water is to 1000g to get composition.
9 honeysuckle of table, dandelion, kuh-seng, Salvia root P.E account for the mass ratio of composition
As seen from Table 9, at 4~12%, gel rubber system is stablized for honeysuckle, dandelion, kuh-seng, Salvia root P.E total amount, But when extract total amount is 14%, the 28th group of preformed gel system is thinning, bad stability.
Light, moderate face acne vulgaris volunteer totally 45 people is chosen, wherein male 23 people, 22 people of female；16~35 years old age put down Equal 26.4 years old；Suffer from journey 4 weeks~6 years, it is 2.8 years average, 2 weeks before sample is smeared, glucocorticosteroid hormone, tretinoin was not used And antibiotics, no hyperlipidemia and hepatic and renal function are abnormal, forbid indulging in excessive drinking, avoid sunburst or ultraviolet light excessive radiation.
45 volunteers are randomly divided into 5 groups, every group of 9 people.Subject cleans pars affecta skin and after drying with warm water, often The composition of early, the late different formulations of smearing respectively 1 time, disables other drugs or cosmetics, judges curative effect after 4 weeks during use. It before the treatment and treats the 4th week, respectively to volunteer's face inflammatory damage total (summation of inflamed papules and warts), non-inflammatory Damage total (summation of Whiteheads and blackhead) counts, while the adverse reaction in detail after record use.Criterion： Base is cured：Therapeutic index >=90%；It is effective：60%≤therapeutic index ＜ 90%；Progress：20%≤therapeutic index ＜ 60%；It is invalid： Therapeutic index ＜ 20%.Total skin lesion number before therapeutic index=(total skin lesion number after total skin lesion number-treatment before treatment)/treatment × 100%.Efficient=(base is cured number of cases+effective number of cases)/whole number of cases × 100%.
It is as shown in table 10 to the therapeutic effect of acne after 4 weeks：
The therapeutic effect of 10 different formulations composition of table
Experiment numbers Base is cured It is effective Progress It is invalid Adverse reaction Total number of cases Efficient (%)
15 2 5 2 / Nothing 9 77.78
24 1 4 4 / Nothing 9 55.56
25 0 0 9 / Nothing 9 0.00
26 3 5 1 / Nothing 9 88.89
27 3 5 1 / Nothing 9 88.89
As seen from Table 10, in the 26th group of experiment, honeysuckle, dandelion, kuh-seng, Salvia root P.E total amount are controlled at 10% Treat efficient higher, but when extract total amount increases to 12%, treated effect is without significantly improving.
Embodiment 5：
10g cards ripple adds in soaked overnight in 700g water, and 2h is stirred in 40 DEG C of heating；50g glycerine is added in, stirs 0.5h；It adds in The 1,3-BDO of 20g stirs 0.5h；The honeysuckle of addition different quality percentage, dandelion, kuh-seng, Salvia root P.E, are stirred Mix 0.5h；The menthol 5g of 80~120 mesh sieves was added in, stirs 1h；10g triethanolamines are added in, stirring 1h forms gel.It supplies Water is to 1000g to get composition.
11 honeysuckle of table, dandelion, kuh-seng, Salvia root P.E account for the mass ratio of composition respectively
Light, moderate face acne vulgaris volunteer totally 108 people is chosen, wherein male 54 people, 54 people of female；Age 16-35 Sui puts down Equal 25.6 years old；Suffer from journey -6 years 4 weeks, average 2.5 years, 2 weeks before sample is smeared, be not used glucocorticosteroid hormone, tretinoin and Antibiotics, no hyperlipidemia and hepatic and renal function are abnormal, forbid indulging in excessive drinking, avoid sunburst or ultraviolet light excessive radiation.
108 volunteers are randomly divided into 12 groups, every group of 9 people.Subject cleans pars affecta skin and after drying with warm water, often The composition of early, the late different formulations of smearing respectively 1 time, disables other drugs or cosmetics, judges curative effect after 4 weeks during use. It before the treatment and treats the 4th week, respectively to volunteer's face inflammatory damage total (summation of inflamed papules and warts), non-inflammatory Damage total (summation of Whiteheads and blackhead) counts, while the adverse reaction in detail after record use.Criterion： Base is cured：Therapeutic index >=90%；It is effective：60%≤therapeutic index ＜ 90%；Progress：20%≤therapeutic index ＜ 60%；It is invalid： Therapeutic index ＜ 20%.Total skin lesion number before therapeutic index=(total skin lesion number after total skin lesion number-treatment before treatment)/treatment × 100%.Efficient=(base is cured number of cases+effective number of cases)/whole number of cases × 100%.
It is as shown in table 12 to the therapeutic effect of acne after 4 weeks：
The therapeutic effect of 12 different formulations composition of table
Experiment numbers Base is cured It is effective Progress It is invalid Adverse reaction Total number of cases Efficient (%)
26 3 5 1 / Nothing 9 88.89
29 6 3 0 / Nothing 9 100.00
30 4 4 1 / Nothing 9 88.89
31 4 4 1 / Nothing 9 88.89
32 4 4 1 / Nothing 9 88.89
33 3 4 2 / Nothing 9 77.78
34 5 3 1 / Nothing 9 88.89
35 5 3 1 / Nothing 9 88.89
36 6 2 1 / Nothing 9 88.89
37 6 2 1 / Nothing 9 88.89
Find out from table 11-12, the treated effect highest of the 29th group of experiment, effect is best, i.e. honeysuckle, dandelion, hardship Ginseng, Salvia root P.E total amount account for the 10% of composition, and each component mass percent is respectively：3% Honegsukle flower P.E, 3% Pu When public English extract, 2% shrubby sophora extract, 2% Salvia root P.E, best results.
Embodiment 6：
10g cards ripple adds in soaked overnight in 700g water, and 2h is stirred in 40 DEG C of heating；50g glycerine is added in, stirs 0.5h；It adds in The 1,3-BDO of 20g stirs 0.5h；Add in 3% Honegsukle flower P.E, 3% dandelion extract, 2% shrubby sophora extract, 2% Salvia root P.E stirs 0.5h；Menthol 5g is added in, stirs 1h；10g triethanolamines are added in, stirring 1h forms gel.It mends Sufficient water to 1000g, wherein, it is 150/min, 180/min, 200r/min to set mixing speed respectively, and menthol granularity is respectively 80 mesh, 100 mesh, 120 mesh.
Table 13 prepares composition using different parameters
Experiment numbers Mixing speed (r/min) Menthol granularity (mesh)
38 150 100
39 180 100
40 200 100
41 150 80
42 150 120
Light, moderate face acne vulgaris volunteer totally 45 people is chosen, wherein male 23 people, 22 people of female；Age 16-35 Sui puts down Equal 26.7 years old；Suffer from journey -6 years 4 weeks, average 3.1 years, 2 weeks before sample is smeared, be not used glucocorticosteroid hormone, tretinoin and Antibiotics, no hyperlipidemia and hepatic and renal function are abnormal, forbid indulging in excessive drinking, avoid sunburst or ultraviolet light excessive radiation.
45 volunteers are randomly divided into 5 groups, every group of 9 people.Subject cleans pars affecta skin and after drying with warm water, often Spread compositions 1 time respectively of early, evening, disables other drugs or cosmetics, judges curative effect after 4 weeks during use.Before the treatment and It treats the 4th week, respectively to volunteer's face inflammatory damage total (summation of inflamed papules and warts), non-inflammatory lesions sum (summation of Whiteheads and blackhead) counts, while the adverse reaction in detail after record use.Criterion：Base is cured：It treats Imitate index >=90%；It is effective：60%≤therapeutic index ＜ 90%；Progress：20%≤therapeutic index ＜ 60%；It is invalid：Curative effect refers to Number ＜ 20%.Total skin lesion number × 100% before therapeutic index=(total skin lesion number after total skin lesion number-treatment before treatment)/treatment.Effectively Rate=(base is cured number of cases+effective number of cases)/whole number of cases × 100%.
It is as shown in table 14 to the therapeutic effect of acne after 4 weeks：
Table 14 prepares the therapeutic effect of composition using different parameters
Find out from table 13-14, in the 38th group of experiment, when in preparation method of the present invention, mixing speed is arranged to 150/min, When menthol granularity is 100 mesh, therapeutic effect is optimal.
Embodiment 7：
Antipruritic, detumescence efficacy assessments are carried out to the composition prepared using the 38th group of experimental method of the present invention.
It chooses by mosquito or other insect bites and has the case of local acutely itch totally 60 people, wherein male 25 people, female 35 People；It is age 16-50 Sui, 35.6 years old average；Before the present composition is smeared, other relieving itching and eliminating swelling methods must not be used；Mosquito Composition concentration prepared by the 38th group of experimental method of the present invention is applied to after biting and is bitten position, when recording antipruritic and detumescence Between, it the results are shown in Table 15-16.
15 present composition antipruritic effect of table
16 present composition of table detumescence effect
The experimental results showed that there are antipruritic effect, and 10 points using the present composition, 93% case after bite by mosquitos Quick itch stopping in clock, 2 interior detumescences when small.
Experiment is also drawn：After bite by mosquitos, more early using effect is better.
Composition and the skin of the present invention has good compatibility, can significantly removing acne, with can be rapidly by skin It absorbs, safety does not stimulate, not allergy, and after composition of the present invention with acne-removing 4 weeks, skin recovers smoothly, to stop Uneasy to recur with rear acne, safely and effectively and effect is lasting.After the composition gels agent of the present invention can be used for bite by mosquitos Relieving itching and eliminating swelling, Quick itch stopping in 10 minutes, 2 interior detumescences when small are quick, safe and reliable.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferable The present invention is described in detail in embodiment, it will be understood by those of ordinary skill in the art that, it can be to the technology of the present invention Scheme is modified or replaced equivalently, and without departing from the spirit and scope of technical solution of the present invention, should all be covered in this hair Among bright right.

Claims (9)

1. a kind of anti-acne and relieving itching and eliminating swelling composition, it is characterised in that：The composition include honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae, wherein, by quality ratio, the honeysuckle：Dandelion：Kuh-seng：Radix Salviae Miltiorrhizae=1.5：1.5：1：1.
2. composition as described in claim 1, it is characterised in that：The composition further includes card ripple, glycerine, 1,3- fourths two Alcohol, triethanolamine, menthol, wherein, by percentage to the quality, the card ripple content is 0.5%~1.5%, the glycerine contains It is 1%~3% to measure as 4%~6%, the 1,3 butylene glycol content, the triethanolamine content is 0.5%~2%, institute peppermint Alcohol content is 0.4%~0.6%, and surplus is water.
3. composition as claimed in claim 2, it is characterised in that：The component of the composition is distinguished by percentage to the quality For：The honeysuckle content is 3%, the dandelion content is 3%, the kuh-seng content is 2%, the Radix Salviae Miltiorrhizae content is 2%th, the card ripple content is 1%, the glycerol content is 5%, the 1,3 butylene glycol content is 2%, the triethanolamine Content is 1%, institute's menthol content is 0.5%, and surplus is water.
4. a kind of preparation method of anti-acne and relieving itching and eliminating swelling composition, it is characterised in that：Including,
Extraction：Dandelion, kuh-seng, Radix Salviae Miltiorrhizae are crushed；By honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae soak, heating extraction, mistake Filter, obtains extracting solution；The extracting solution is concentrated, is cooled down to get extract；
It prepares：Card ripple soaked overnight, heats and stirs；Add in glycerine, stirring；Add in 1,3-BDO, stirring；Add in the warp The honeysuckle of extraction, dandelion, kuh-seng, Salvia root P.E, stirring；Add in menthol, stirring；Triethanolamine is added in, stirs shape Into gel.
5. preparation method as claimed in claim 4, it is characterised in that：The extraction, wherein, it is described by dandelion, kuh-seng, pellet Ginseng crushes, and is that the dandelion, kuh-seng, Radix Salviae Miltiorrhizae are crushed to below 2.0cm；It is described to soak, it is by the honeysuckle, Pu Public English, kuh-seng, Radix Salviae Miltiorrhizae add in the water that mass ratio is 5~15 times, and the soaking time is 12h；The heating extraction, temperature 70 ~90 DEG C, the time is 0.5~2h；Described to concentrate the extracting solution, the thickening temperature is 60 DEG C；The cooling, is cooled to Temperature is 35~45 DEG C.
6. preparation method as described in claim 4 or 5, it is characterised in that：The extraction, wherein, it is described to soak, be by The honeysuckle, dandelion, kuh-seng, Radix Salviae Miltiorrhizae add in the water that mass ratio is 10 times, the heating extraction, and temperature is 80 DEG C, the time For 1h；Described to concentrate the extracting solution, the thickening temperature is 60 DEG C, is concentrated into solid-liquid ratio as 1:1.25, unit g:ml.
7. preparation method as claimed in claim 6, it is characterised in that：The preparation, wherein, the card ripple soaked overnight adds Heat simultaneously stirs, 40 DEG C of the heating temperature, and the mixing time is 2h；The addition glycerine, stirring, time 0.5h；It is described to add Enter 1,3-BDO, stir, time 0.5h；It is described to add in extracted honeysuckle, dandelion, kuh-seng, Salvia root P.E, it stirs It mixes, time 0.5h；The addition menthol, stirring, to add in the menthol of 80~120 mesh, the mixing time is 1h；Institute Addition triethanolamine is stated, stirring forms gel, time 1h.
8. the preparation method as described in claim 4,5 or 7, it is characterised in that：The preparation, wherein, by percentage to the quality, The card ripple addition is 1%, the glycerine input is 5%, the 1,3 butylene glycol addition is 2%, three ethyl alcohol Amine addition is 1%, the honeysuckle addition is 3%, the dandelion addition is 3%, the kuh-seng addition is 2%th, the Radix Salviae Miltiorrhizae addition is 2%, institute's menthol addition is 0.5%, and surplus is water.
9. preparation method as claimed in claim 8, it is characterised in that：The preparation, wherein, the speed of the stirring is 150r/min, the addition menthol, to add in the menthol of 100 mesh.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1137389A (en) * 1995-06-06 1996-12-11 赵可新 Method for preparation of medicine for external use and its emulsion for curing acne
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1137389A (en) * 1995-06-06 1996-12-11 赵可新 Method for preparation of medicine for external use and its emulsion for curing acne
CN103751638A (en) * 2014-01-06 2014-04-30 孙贵雨 Acne damp-clearing complexing agent and preparation method thereof

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