The content of the invention
In view of the deficiencies of the prior art, the technical problems to be solved by the invention, which are to provide, a kind of is suitable for the puerperium middle and later periods
Chinese medicine composition of puerpera's lactagogue and preparation method thereof, can effectively ensure that the lactagogue effect of puerperium middle and later periods puerpera.
To achieve these goals, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:Ligusticum wallichii 5-15g,
Profound Hu 5-15g, stem pith of the rice-paper plant 5-15g, safflower 5-15g, dried orange peel 5-15g, radix glycyrrhizae 5-15g, rhizoma cyperi 5-15g, motherwort 10-15g, fennel fruit
It is fragrant 5-15g, hawthorn 20-30g, Radix Rhapontici seu Radix Echinopsis 20-25g, Angelica sinensis 5-8g, pangolin 20-40g, Radix Codonopsis 20-25g, radix astragali 10-20g, white
Chinese herbaceous peony 10-20g, seed of cowherb 20-30g.
A kind of preparation method of Chinese medicine composition, comprises the following steps:
(1) each material medicine is weighed by weight, is mixed, and the water for adding 10-15 times of mixed material drug weight decocts 2-3
Secondary, each 1-1.5h, merges decocting liquid, freezes, and Chinese medicine freeze-dried powder is made;
(2) biofermentation is used, Chinese medicine freeze-dried powder is seeded in the mixed bacteria liquid of 10-20 times of weight, sealed fermenting 30-
50h, the mixed bacteria liquid include:Bacillus subtilis 2 × 108Cfu/mL, Lactobacillus casei 3 × 108Cfu/mL, plant breast
Bacillus 2 × 108Cfu/mL, bifidobacterium breve 1 × 108Cfu/mL, saccharomycete 1 × 108cfu/mL;
(3) by zymotic fluid after filtering, it is canned to obtain the final product.
A kind of preparation method of Chinese medicine composition, weighs each material medicine by weight, and mixing, adds mixed material medicine weight
The water of 10-15 times of amount decocts 2-3 times, each 1-1.5h, merges decocting liquid.
A kind of preparation method of Chinese medicine composition, comprises the following steps:
(1) Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel are weighed by weight, is mixed, and add 5-15 times of mixed material drug weight
Volumetric concentration 90% ethanol, refluxing extraction 2-3 times under the conditions of 70-80 DEG C, each 1-1.5h, filtering, merging filtrate warp
Ethanol is recovered under reduced pressure to no alcohol taste, and is condensed into the extractum A that relative density at 60 DEG C is 1.10-1.12;
(2) radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, king are weighed by weight
Row is not stayed, is mixed, the water for adding 10-15 times of mixed material drug weight decocts 2-3 times, each 1-1.5h, filtering, merging filtrate
And it is condensed into the medicinal extract B that relative density at 80 DEG C is 1.20-1.30;
(3) 100 mesh sieves are crossed after pangolin is crushed, it is spare;
(4) extractum A, medicinal extract B are uniformly mixed, concentrate, be dried to dry extract, crushed, and the mixing of pangolin powder, Ran Houjia
Enter auxiliary material, remix uniformly, pelletize, it is dry, to obtain the final product.
Auxiliary material is starch, dextrin or white sugar, and dosage is the 20-30% of material medicine gross weight.
The pharmacology of each component of the present invention is as follows:
Ligusticum wallichii, acrid flavour are warm-natured.Return liver, gallbladder channel.Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.It is dizzy to cure mainly air-cooled headache rotation,
Hypochondriac pain abdomen aches, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, closed dysmenorrhea, lump in the abdomen abdomen
Bitterly, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Profound Hu, acrid flavour is bitter, warm-natured.Return liver warp, stomach, the heart, warp, the spleen channel.Promoting blood circulation, dissipates the stasis of blood, qi-regulating, analgesic.Cure mainly trusted subordinate's waist
The all pains of knee, irregular menstruation, abdominal mass, metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury.
The stem pith of the rice-paper plant, sweet in flavor, cold nature.Attach to the lung and stomach meridians.Clear wet Li Shui;Promoting lactation.Cure mainly the puckery pain of stranguria, difficult urination, oedema,
Jaundice, damp-warm diseases, scanty drak urine, postpartum breast is few, Amenorrhea, under band.For damp-warm syndrome urine, the puckery pain of gonorrhoea, oedema oliguria, milk is not
Under.
Safflower, acrid flavour are warm-natured.Converge to heart and liver channels.Invigorate blood circulation, stasis eliminatings analgesic.Cure mainly Amenorrhea, abdominal mass, difficult labour, stillborn foetus, production
Lochia, hemostasis are had a pain afterwards, carbuncle swells, injury from falling down.
Dried orange peel, it is bitter, pungent, it is warm-natured.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.Abdominal fullness and distention is cured mainly, deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Radix glycyrrhizae, it is sweet in flavor, it is mild-natured.The thoughts of returning home, spleen, lung, stomach.Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, it is clearing heat and detoxicating, alleviate analgesic, delay
And pharmacological property.
Rhizoma cyperi, acrid flavour, slight bitter, micro-sweet are mild-natured.Return liver, spleen, tri-jiao channel.Regulating the flow of vital energy Xie Yu, relieves pain menstruation regulating.Cure mainly liver stomach not
With, depression of QI, phlegm and retained fluid feeling of fullness, under uterine bleeding band, stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia
Abdominal pain, swollen breasts, irregular menstruation, closed dysmenorrhea.《Detailed outline》Carry:" gas is trembled with fear epidemic disease when dissipating, and profit three is burnt, Xie Liuyu, the diet that disappears product
Poly-, phlegm and retained fluid feeling of fullness, instep swells, abdominal distension, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, and ulcer sores, spit blood, lower blood, urine
Blood, under married woman's uterine bleeding band, the moon waits uncomfortable, postpartum all kinds of diseases and ailments before tire.”
Motherwort, it is bitter, pungent, it is cold in nature.The thoughts of returning home, liver, bladder warp.It is promoting blood circulation and removing blood stasis, inducing diuresis for removing edema.Irregular menstruation is cured mainly, is produced
Stasis blocking afterwards, traumatic injury, oedema, difficult urination, sore and toxic, itchy skin eruption.
Fennel seeds, acrid flavour are warm-natured.Return kidney channel.Stomach invigorating, promoting the circulation of qi, analgesic.Cure mainly stomach cold pain, cold and pain in the lower abdomen, dysmenorrhoea, colic,
Hydrocele testis, snail fever.
Hawthorn, sour sweet, slightly warm in nature.Returns spleen, stomach, Liver Channel.Digestion gathered food, scattered blood stasis, expelling tenia.Control meat product, abdominal mass, phlegm
Drink, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia postpartum postpartum abdominal pain, lochiorrhagia, pediatric milk food stagnation.Food digesting stomach fortifying, OK
Gas dissipates the stasis of blood.For meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain, height
Blood fat disease.
Radix Rhapontici seu Radix Echinopsis, bitter are cold in nature.Return stomach.Clearing heat and detoxicating, disappear carbuncle, and lower breast, relaxing muscles and tendons is promoted blood circulation.Cure mainly acute mastitis swelling and pain, ulcer hair
The back of the body, scrofula sore, alactation, arthritis with fixed pain caused by dampness contraction.
Angelica sinensis, it is sweet in flavor, pungent, it is warm-natured.Return liver, the heart, the spleen channel.Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.The main deficiency of blood is all
Card, irregular menstruation, Amenorrhea, dysmenorrhoea, abdominal mass knot gather, and uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, weight after dysentery characterized by blood in the stool,
Ulcer sores, injury from falling down.
Pangolin, taste is salty, cold nature;Return liver, stomach.Blood circulation promoting and dispersing pathogen accumulation, newborn under promoting menstruation, anti-stain in solid.Cure mainly blood stasis,
Abdominal mass, arthralgia pain due to rheumatism, agalactia, carbuncle swells, scrofula.《Detailed outline》Carry:" eliminating phlegm malaria fever and chills, the tetanic pain of wandering arthritis, qualcomm meridian, under
Milk, subduing inflammation, apocenosis blood, sensible desinsection ".
Radix Codonopsis, it is sweet in flavor, it is mild-natured.Returns spleen, lung channel.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.Spleen eating less loose stool is cured mainly,
Weakness of limbs, palpitaition, shortness of breath, dry, spontaneous perspiration, rectal prolapse, the prolapse of uterus.Rhizoma zingiberis, acrid flavour, property heat.Returns spleen, stomach, kidney, the heart, lung channel.Middle benefit gas
Cold dispelling, Back to Yang Tongmai, Wenfei of drink.Cure mainly coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, cold drink breathes with cough.
Radix astragali, sweet in flavor, slightly warm in nature.Return lung, spleen, liver and kidney channel.Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.Cure mainly
Treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood
It is sallow, Heat Diabetes.
Radix Paeoniae Alba, bitter, acid, cold nature.Return liver, the spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.It is main
Control blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, dizziness of having a headache.
The seed of cowherb, bitter are mild-natured.Return liver, stomach.Invigorate blood circulation, lower breast detumescence, inducing diuresis for treating strangurtia.Amenorrhea is cured mainly, pain
Through, agalactia, acute mastitis swelling and pain, the puckery pain of stranguria.
Beneficial effects of the present invention:
The Chinese medicine composition of the present invention is according to the own metabolism and circulation law of more than 15 days postpartum puerpera, i.e., itself has been
Internal filth is discharged, channels and collaterals slowly recover, if no galactopoiesis illustrates blockage of main and collateral channels, deficiency of vital energy and blood, mammary gland circulation is obstructed, member
For unsaturated vapor, it is necessary to have additional nutrients, the present invention researches and develops lactagogue Chinese medicine for the puerpera in the period, is particularly suitable for weak type of qi and blood and lacks
Newborn disease, stresses benefiting qi and nourishing blood, while has blood circulation invigorating efficacies concurrently, qi-blood tonifying, and newborn under promoting menstruation, lactagogue effect is more notable, also
The proliferation of mammary gland can be treated, to promoting breast-feeding to be of great significance, and Chinese medicine of the present invention can improve puerpera and baby
Resistance.
The present invention is made of pure natural raw material Chinese herbal medicine, and Radix Rhapontici seu Radix Echinopsis, the seed of cowherb are monarch drug in a prescription in prescription, and safflower, Angelica sinensis, lead to
Grass, Ligusticum wallichii, pangolin are ministerial drug, respectively into benefiting qi and nourishing blood is focused on after subassembly, have concurrently promoting blood circulation and removing blood stasis, can treat the proliferation of mammary gland and urge
Breast.Each component compatibility is reasonable, and synergistic, curative effect is good, and cost is low, is the Innovative TCMs of postpartum lactagogue.
The present invention uses biotechnology fermentation in technique, can improve mouthfeel, realizes curative effect speed-raising, attenuation synergistic, effect
More preferably.
Formulation of the present invention can make the formulations such as decoction, granule or pill according to the market demand, convenient to take.
Chinese medicine of the present invention is without any side effects, and curative effect is obvious, and cure rate is higher, statistics show total effective rate 95% with
On.General symptom takes effect in 3 days, even served 3-6 days and cures.
Embodiment 3
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:It is Ligusticum wallichii 15g, profound
Hu 15g, stem pith of the rice-paper plant 15g, safflower 15g, dried orange peel 15g, radix glycyrrhizae 15g, rhizoma cyperi 15g, motherwort 15g, fennel seeds 15g, hawthorn 30g, leakage
Reed 25g, Angelica sinensis 8g, pangolin 40g, Radix Codonopsis 25g, radix astragali 20g, Radix Paeoniae Alba 20g, seed of cowherb 30g.
Preparation method, comprises the following steps:
(1) Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel are weighed by weight, is mixed, and add 5 times of mixed material drug weight
The ethanol of volumetric concentration 90%, refluxing extraction 3 times under the conditions of 70 DEG C, each 1h, filtering, merging filtrate is through being recovered under reduced pressure ethanol
To no alcohol taste, and it is condensed into the extractum A that relative density at 60 DEG C is 1.10-1.12;
(2) radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, king are weighed by weight
Row is not stayed, is mixed, the water for adding 10 times of mixed material drug weight decocts 3 times, each 1h, and filtering, merging filtrate is simultaneously condensed into
Relative density is the medicinal extract B of 1.20-1.30 at 80 DEG C;
(3) 100 mesh sieves are crossed after pangolin is crushed, it is spare;
(4) extractum A, medicinal extract B are uniformly mixed, concentrate, be dried to dry extract, crushed, and the mixing of pangolin powder, Ran Houjia
Enter the starch of material medicine gross weight 20%, remix uniformly, pelletize, it is dry, to obtain the final product.
Relevant clinical data is as follows:
1st, case selection:
160 clinical observations of hypogalactia after delivery patient (more than 15 days postpartum) made a definite diagnosis are selected, patient is randomly divided into treatment 1-3
Group and control group, treatment group women 120, age 26-35 Sui, average age 29.3 years old, the course of disease most short person 15 days, most elder 30
My god, it is 21 days average.Control group women 40, age 23-34 Sui, average age 29.1 years old, the course of disease most short person 20 days, most elder 28
My god, it is 25 days average.The course of disease for the treatment of group and control group case, degrees of symptoms are basically identical, no significant difference, have comparable
Property.
2nd, therapeutic scheme:
Chinese medicine composition (embodiment 1-3) of the present invention is taken by treatment group, takes orally, one portion per day, point takes for each 1 time sooner or later;3
It is 1 course for the treatment of, 1 course for the treatment of of the lighter, 2 courses for the treatment of of severe one.Control group takes CuiRu KeLi, and by specification is taken.During medication
Daily observation cesarean lactation situation, during which lactation amount normally can withdrawal, statistical analysis is carried out to result after a week.
3rd, efficacy determination:
(1) cure:Breast without distending pain, without enclosed mass, have rosy cheeks, spirit still, voice is loud and clear, and arteries and veins is strong, and sleep is normal,
Galactosis amount recovers normal.
(2) it is effective:Patient's malaise symptoms mitigate, and galactosis amount increases.
(3) it is invalid:Symptom is without change.
Total effective rate=cure rate+obvious effective rate
4th, result:
Group |
Number of cases (a) |
Cure (a/%) |
Effective (a/%) |
Invalid (a/%) |
Total effective rate (%) |
Embodiment 1 |
40 |
25/62.5% |
15/37.5% |
0/0% |
100.0% |
Embodiment 2 |
40 |
23/57.5% |
15/37.5% |
2/5.0% |
95.0% |
Embodiment 3 |
40 |
25/62.5% |
14/35.0% |
1/2.5% |
97.5% |
Control group |
40 |
19/47.5% |
14/35.0% |
7/17.5% |
82.5% |
The result shows that the cure rate and total effective rate for the treatment of group are obviously higher than control group.Illustrate the Chinese medicine group of the present invention
Puerpera lactagogue of the compound to the puerperium middle and later periods works well.
Model case is illustrated:
Case 1, Mr. Wang, female, 29 years old, Henan people from Xuchang.20 days postpartum, during which household was that it has been looked for much also without lower breast
The recipe that stimulates the secretion of milk is eaten, as peanut trotter stews, gold carp soup etc., but all there is no effect, Chinese medicine of the present invention is taken, is taken orally, daily one
Agent, point takes for each 1 time sooner or later, after taking 3 days, starts lactation, after taking 6 days, galactosis amount recovers normal.Follow-up one
A month, puerpera's galactosis amount was normal.
Case 2, Lee, female, 28 years old, District, Xinyang Area, Henan Province people.5 days postpartum no lower breast, is stimulated the secretion of milk in hospital using gimmick, parallel port
The medicine that hospital issues is taken, milk is still rare, and 20 days postpartum started to take Chinese medicine of the present invention, takes orally, one portion per day, point morning and evening
Take for each 1 time, after taking 2 days, galactosis amount increases, and after taking 6 days, galactosis amount recovers normal.Follow-up one month, production
Woman's galactosis amount is normal.
Case 3, poplar, female, 26 years old, Henan Zhumadian people.4 days postpartum added the recipe that stimulates the secretion of milk without lower breast, the oral tea that stimulates the secretion of milk,
Such as gold carp soup, milk is still rare, and 16 days postpartum started to take Chinese medicine of the present invention, takes orally, one portion per day, point sooner or later each 1 clothes
With after taking 3 days, galactosis amount increases, and after taking 6 days, galactosis amount recovers normal.Follow-up one month, puerpera's milk
Secretory volume is normal.