CN108030851A - It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof - Google Patents

It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof Download PDF

Info

Publication number
CN108030851A
CN108030851A CN201810118939.6A CN201810118939A CN108030851A CN 108030851 A CN108030851 A CN 108030851A CN 201810118939 A CN201810118939 A CN 201810118939A CN 108030851 A CN108030851 A CN 108030851A
Authority
CN
China
Prior art keywords
radix
chinese medicine
puerpera
weight
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810118939.6A
Other languages
Chinese (zh)
Inventor
樊国欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diguo Biotechnology Co., Ltd.
Original Assignee
Henan Di Guo Science And Technology Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Di Guo Science And Technology Development Co Ltd filed Critical Henan Di Guo Science And Technology Development Co Ltd
Priority to CN201810118939.6A priority Critical patent/CN108030851A/en
Publication of CN108030851A publication Critical patent/CN108030851A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235Foeniculum (fennel)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof, including following material medicine:Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel, radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, pangolin, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, the seed of cowherb.The Chinese medicine composition of the present invention is according to the own metabolism and circulation law of more than 15 days postpartum puerpera, internal filth itself is had been drained off, channels and collaterals slowly recover, if no galactopoiesis illustrates blockage of main and collateral channels, deficiency of vital energy and blood, mammary gland circulation is obstructed, insufficiency of primordial QI, need to have additional nutrients, the present invention researches and develops lactagogue Chinese medicine for the puerpera in the period, it is particularly suitable for qi-blood asthenia type hypogalactia disease, stress benefiting qi and nourishing blood, have blood circulation invigorating efficacies concurrently at the same time, it is qi-blood tonifying, it is newborn under promoting menstruation, lactagogue effect is more notable, the proliferation of mammary gland can also be treated, to promoting breast-feeding to be of great significance, and Chinese medicine of the present invention can improve the resistance of puerpera and baby.

Description

It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof
Technical field
The present invention relates to a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof, in belonging to Medicine field.
Background technology
Breast milk is the juice for being used as nurture baby that postpartum female breast produces, in breast milk containing lactoferrin (important), Carbohydrate, protein, fat, vitamin, mineral matter, aliphatic acid and taurine etc., are that neonate is main initial stage of being born Nutriment source.Breast-feeding is all beneficial for newborn woman and natus, and breast milk is full of nutrition, is easy to digest, and dirty Contaminate less and contain a variety of antibacteriums and antiviral antibody, baby's illness rate and the death rate can be reduced, be conducive to pregnant woman's postpartum Recover in palace.However, breast milk is obstructed or hypogalactia, agalasisa become puerpera's common disease.Puerpera in lactation milk very less or completely without, deficiency Enough persons that is even unable to feeding infant, are known as hypogalactia after delivery.Hypogalactia after delivery not only influences the normal lactation of puerpera, influences the strong of baby Kang Shengchang, while also psychological pressure is brought to puerpera and household.Postpartum milk rareness ancients have discussion more, such as《Married woman is good Side》Claim, married woman's milk is qi and blood, and sub- milk is given birth to if vigour weakness and is lacked.It is bright《Production mirror》Referred to as alactation, Zhang Jingyue " benefitization source and claim tonneau " is proposed to chronic diseases marked by deficiency of vital energy hypogalactia.At present, it is many that method and the medicine of hypogalactia of lying-in woman disease are treated, it is among the people just to have The dietotherapy of more treatment hypogalactias or special prescription of Chinese herbal medicine, have the effect of certain to treatment hypogalactia of lying-in woman, but can seldom reach satisfied effect, And effect is slow, cure rate is low, the best opportunity (3-15 days postpartum) of lactagogue is often missed.After puerpera produces 15 days, body is each Compared with before postpartum 15 days significant change occurs for item index, at present there has been no the lactagogue product for different phase puerpera, lacks Effective specific aim.
The content of the invention
In view of the deficiencies of the prior art, the technical problems to be solved by the invention, which are to provide, a kind of is suitable for the puerperium middle and later periods Chinese medicine composition of puerpera's lactagogue and preparation method thereof, can effectively ensure that the lactagogue effect of puerperium middle and later periods puerpera.
To achieve these goals, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:Ligusticum wallichii 5-15g, Profound Hu 5-15g, stem pith of the rice-paper plant 5-15g, safflower 5-15g, dried orange peel 5-15g, radix glycyrrhizae 5-15g, rhizoma cyperi 5-15g, motherwort 10-15g, fennel fruit It is fragrant 5-15g, hawthorn 20-30g, Radix Rhapontici seu Radix Echinopsis 20-25g, Angelica sinensis 5-8g, pangolin 20-40g, Radix Codonopsis 20-25g, radix astragali 10-20g, white Chinese herbaceous peony 10-20g, seed of cowherb 20-30g.
A kind of preparation method of Chinese medicine composition, comprises the following steps:
(1) each material medicine is weighed by weight, is mixed, and the water for adding 10-15 times of mixed material drug weight decocts 2-3 Secondary, each 1-1.5h, merges decocting liquid, freezes, and Chinese medicine freeze-dried powder is made;
(2) biofermentation is used, Chinese medicine freeze-dried powder is seeded in the mixed bacteria liquid of 10-20 times of weight, sealed fermenting 30- 50h, the mixed bacteria liquid include:Bacillus subtilis 2 × 108Cfu/mL, Lactobacillus casei 3 × 108Cfu/mL, plant breast Bacillus 2 × 108Cfu/mL, bifidobacterium breve 1 × 108Cfu/mL, saccharomycete 1 × 108cfu/mL;
(3) by zymotic fluid after filtering, it is canned to obtain the final product.
A kind of preparation method of Chinese medicine composition, weighs each material medicine by weight, and mixing, adds mixed material medicine weight The water of 10-15 times of amount decocts 2-3 times, each 1-1.5h, merges decocting liquid.
A kind of preparation method of Chinese medicine composition, comprises the following steps:
(1) Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel are weighed by weight, is mixed, and add 5-15 times of mixed material drug weight Volumetric concentration 90% ethanol, refluxing extraction 2-3 times under the conditions of 70-80 DEG C, each 1-1.5h, filtering, merging filtrate warp Ethanol is recovered under reduced pressure to no alcohol taste, and is condensed into the extractum A that relative density at 60 DEG C is 1.10-1.12;
(2) radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, king are weighed by weight Row is not stayed, is mixed, the water for adding 10-15 times of mixed material drug weight decocts 2-3 times, each 1-1.5h, filtering, merging filtrate And it is condensed into the medicinal extract B that relative density at 80 DEG C is 1.20-1.30;
(3) 100 mesh sieves are crossed after pangolin is crushed, it is spare;
(4) extractum A, medicinal extract B are uniformly mixed, concentrate, be dried to dry extract, crushed, and the mixing of pangolin powder, Ran Houjia Enter auxiliary material, remix uniformly, pelletize, it is dry, to obtain the final product.
Auxiliary material is starch, dextrin or white sugar, and dosage is the 20-30% of material medicine gross weight.
The pharmacology of each component of the present invention is as follows:
Ligusticum wallichii, acrid flavour are warm-natured.Return liver, gallbladder channel.Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.It is dizzy to cure mainly air-cooled headache rotation, Hypochondriac pain abdomen aches, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, closed dysmenorrhea, lump in the abdomen abdomen Bitterly, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Profound Hu, acrid flavour is bitter, warm-natured.Return liver warp, stomach, the heart, warp, the spleen channel.Promoting blood circulation, dissipates the stasis of blood, qi-regulating, analgesic.Cure mainly trusted subordinate's waist The all pains of knee, irregular menstruation, abdominal mass, metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury.
The stem pith of the rice-paper plant, sweet in flavor, cold nature.Attach to the lung and stomach meridians.Clear wet Li Shui;Promoting lactation.Cure mainly the puckery pain of stranguria, difficult urination, oedema, Jaundice, damp-warm diseases, scanty drak urine, postpartum breast is few, Amenorrhea, under band.For damp-warm syndrome urine, the puckery pain of gonorrhoea, oedema oliguria, milk is not Under.
Safflower, acrid flavour are warm-natured.Converge to heart and liver channels.Invigorate blood circulation, stasis eliminatings analgesic.Cure mainly Amenorrhea, abdominal mass, difficult labour, stillborn foetus, production Lochia, hemostasis are had a pain afterwards, carbuncle swells, injury from falling down.
Dried orange peel, it is bitter, pungent, it is warm-natured.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.Abdominal fullness and distention is cured mainly, deficiency of food is vomited and diarrhoea, Coughing with a lot of sputum.
Radix glycyrrhizae, it is sweet in flavor, it is mild-natured.The thoughts of returning home, spleen, lung, stomach.Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, it is clearing heat and detoxicating, alleviate analgesic, delay And pharmacological property.
Rhizoma cyperi, acrid flavour, slight bitter, micro-sweet are mild-natured.Return liver, spleen, tri-jiao channel.Regulating the flow of vital energy Xie Yu, relieves pain menstruation regulating.Cure mainly liver stomach not With, depression of QI, phlegm and retained fluid feeling of fullness, under uterine bleeding band, stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia Abdominal pain, swollen breasts, irregular menstruation, closed dysmenorrhea.《Detailed outline》Carry:" gas is trembled with fear epidemic disease when dissipating, and profit three is burnt, Xie Liuyu, the diet that disappears product Poly-, phlegm and retained fluid feeling of fullness, instep swells, abdominal distension, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, and ulcer sores, spit blood, lower blood, urine Blood, under married woman's uterine bleeding band, the moon waits uncomfortable, postpartum all kinds of diseases and ailments before tire.”
Motherwort, it is bitter, pungent, it is cold in nature.The thoughts of returning home, liver, bladder warp.It is promoting blood circulation and removing blood stasis, inducing diuresis for removing edema.Irregular menstruation is cured mainly, is produced Stasis blocking afterwards, traumatic injury, oedema, difficult urination, sore and toxic, itchy skin eruption.
Fennel seeds, acrid flavour are warm-natured.Return kidney channel.Stomach invigorating, promoting the circulation of qi, analgesic.Cure mainly stomach cold pain, cold and pain in the lower abdomen, dysmenorrhoea, colic, Hydrocele testis, snail fever.
Hawthorn, sour sweet, slightly warm in nature.Returns spleen, stomach, Liver Channel.Digestion gathered food, scattered blood stasis, expelling tenia.Control meat product, abdominal mass, phlegm Drink, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia postpartum postpartum abdominal pain, lochiorrhagia, pediatric milk food stagnation.Food digesting stomach fortifying, OK Gas dissipates the stasis of blood.For meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain, height Blood fat disease.
Radix Rhapontici seu Radix Echinopsis, bitter are cold in nature.Return stomach.Clearing heat and detoxicating, disappear carbuncle, and lower breast, relaxing muscles and tendons is promoted blood circulation.Cure mainly acute mastitis swelling and pain, ulcer hair The back of the body, scrofula sore, alactation, arthritis with fixed pain caused by dampness contraction.
Angelica sinensis, it is sweet in flavor, pungent, it is warm-natured.Return liver, the heart, the spleen channel.Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.The main deficiency of blood is all Card, irregular menstruation, Amenorrhea, dysmenorrhoea, abdominal mass knot gather, and uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, weight after dysentery characterized by blood in the stool, Ulcer sores, injury from falling down.
Pangolin, taste is salty, cold nature;Return liver, stomach.Blood circulation promoting and dispersing pathogen accumulation, newborn under promoting menstruation, anti-stain in solid.Cure mainly blood stasis, Abdominal mass, arthralgia pain due to rheumatism, agalactia, carbuncle swells, scrofula.《Detailed outline》Carry:" eliminating phlegm malaria fever and chills, the tetanic pain of wandering arthritis, qualcomm meridian, under Milk, subduing inflammation, apocenosis blood, sensible desinsection ".
Radix Codonopsis, it is sweet in flavor, it is mild-natured.Returns spleen, lung channel.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.Spleen eating less loose stool is cured mainly, Weakness of limbs, palpitaition, shortness of breath, dry, spontaneous perspiration, rectal prolapse, the prolapse of uterus.Rhizoma zingiberis, acrid flavour, property heat.Returns spleen, stomach, kidney, the heart, lung channel.Middle benefit gas Cold dispelling, Back to Yang Tongmai, Wenfei of drink.Cure mainly coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, cold drink breathes with cough.
Radix astragali, sweet in flavor, slightly warm in nature.Return lung, spleen, liver and kidney channel.Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.Cure mainly Treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood It is sallow, Heat Diabetes.
Radix Paeoniae Alba, bitter, acid, cold nature.Return liver, the spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.It is main Control blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, dizziness of having a headache.
The seed of cowherb, bitter are mild-natured.Return liver, stomach.Invigorate blood circulation, lower breast detumescence, inducing diuresis for treating strangurtia.Amenorrhea is cured mainly, pain Through, agalactia, acute mastitis swelling and pain, the puckery pain of stranguria.
Beneficial effects of the present invention:
The Chinese medicine composition of the present invention is according to the own metabolism and circulation law of more than 15 days postpartum puerpera, i.e., itself has been Internal filth is discharged, channels and collaterals slowly recover, if no galactopoiesis illustrates blockage of main and collateral channels, deficiency of vital energy and blood, mammary gland circulation is obstructed, member For unsaturated vapor, it is necessary to have additional nutrients, the present invention researches and develops lactagogue Chinese medicine for the puerpera in the period, is particularly suitable for weak type of qi and blood and lacks Newborn disease, stresses benefiting qi and nourishing blood, while has blood circulation invigorating efficacies concurrently, qi-blood tonifying, and newborn under promoting menstruation, lactagogue effect is more notable, also The proliferation of mammary gland can be treated, to promoting breast-feeding to be of great significance, and Chinese medicine of the present invention can improve puerpera and baby Resistance.
The present invention is made of pure natural raw material Chinese herbal medicine, and Radix Rhapontici seu Radix Echinopsis, the seed of cowherb are monarch drug in a prescription in prescription, and safflower, Angelica sinensis, lead to Grass, Ligusticum wallichii, pangolin are ministerial drug, respectively into benefiting qi and nourishing blood is focused on after subassembly, have concurrently promoting blood circulation and removing blood stasis, can treat the proliferation of mammary gland and urge Breast.Each component compatibility is reasonable, and synergistic, curative effect is good, and cost is low, is the Innovative TCMs of postpartum lactagogue.
The present invention uses biotechnology fermentation in technique, can improve mouthfeel, realizes curative effect speed-raising, attenuation synergistic, effect More preferably.
Formulation of the present invention can make the formulations such as decoction, granule or pill according to the market demand, convenient to take.
Chinese medicine of the present invention is without any side effects, and curative effect is obvious, and cure rate is higher, statistics show total effective rate 95% with On.General symptom takes effect in 3 days, even served 3-6 days and cures.
Embodiment
The embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:Ligusticum wallichii 5g, profound Hu 5g, stem pith of the rice-paper plant 5g, safflower 5g, dried orange peel 5g, radix glycyrrhizae 5g, rhizoma cyperi 5g, motherwort 10g, fennel seeds 5g, hawthorn 20g, Radix Rhapontici seu Radix Echinopsis 20g, Angelica sinensis 5g, pangolin 20g, Radix Codonopsis 20g, radix astragali 10g, Radix Paeoniae Alba 10g, seed of cowherb 20g.
Preparation method, comprises the following steps:
(1) each material medicine is weighed by weight, is mixed, the water decoction of 10 times of addition mixed material drug weight 3 times, every time 1.5h, merges decocting liquid, freezes, and Chinese medicine freeze-dried powder is made;
(2) biofermentation is used, Chinese medicine freeze-dried powder is seeded in the mixed bacteria liquid of 15 times of weight, sealed fermenting 40h, institute Stating mixed bacteria liquid includes:Bacillus subtilis 2 × 108Cfu/mL, Lactobacillus casei 3 × 108Cfu/mL, lactobacillus plantarum 2 × 108Cfu/mL, bifidobacterium breve 1 × 108Cfu/mL, saccharomycete 1 × 108cfu/mL;
(3) by zymotic fluid after filtering, it is canned to obtain the final product.
Embodiment 2
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:It is Ligusticum wallichii 10g, profound Hu 10g, stem pith of the rice-paper plant 10g, safflower 10g, dried orange peel 10g, radix glycyrrhizae 10g, rhizoma cyperi 10g, motherwort 12g, fennel seeds 10g, hawthorn 25g, leakage Reed 22g, Angelica sinensis 6g, pangolin 30g, Radix Codonopsis 22g, radix astragali 15g, Radix Paeoniae Alba 15g, seed of cowherb 25g.
Preparation method, comprises the following steps:Each material medicine is weighed by weight, is mixed, and adds mixed material drug weight 15 times of water decocts 2 times, each 1h, merges decocting liquid.
Embodiment 3
A kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, including following material medicine:It is Ligusticum wallichii 15g, profound Hu 15g, stem pith of the rice-paper plant 15g, safflower 15g, dried orange peel 15g, radix glycyrrhizae 15g, rhizoma cyperi 15g, motherwort 15g, fennel seeds 15g, hawthorn 30g, leakage Reed 25g, Angelica sinensis 8g, pangolin 40g, Radix Codonopsis 25g, radix astragali 20g, Radix Paeoniae Alba 20g, seed of cowherb 30g.
Preparation method, comprises the following steps:
(1) Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel are weighed by weight, is mixed, and add 5 times of mixed material drug weight The ethanol of volumetric concentration 90%, refluxing extraction 3 times under the conditions of 70 DEG C, each 1h, filtering, merging filtrate is through being recovered under reduced pressure ethanol To no alcohol taste, and it is condensed into the extractum A that relative density at 60 DEG C is 1.10-1.12;
(2) radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, king are weighed by weight Row is not stayed, is mixed, the water for adding 10 times of mixed material drug weight decocts 3 times, each 1h, and filtering, merging filtrate is simultaneously condensed into Relative density is the medicinal extract B of 1.20-1.30 at 80 DEG C;
(3) 100 mesh sieves are crossed after pangolin is crushed, it is spare;
(4) extractum A, medicinal extract B are uniformly mixed, concentrate, be dried to dry extract, crushed, and the mixing of pangolin powder, Ran Houjia Enter the starch of material medicine gross weight 20%, remix uniformly, pelletize, it is dry, to obtain the final product.
Relevant clinical data is as follows:
1st, case selection:
160 clinical observations of hypogalactia after delivery patient (more than 15 days postpartum) made a definite diagnosis are selected, patient is randomly divided into treatment 1-3 Group and control group, treatment group women 120, age 26-35 Sui, average age 29.3 years old, the course of disease most short person 15 days, most elder 30 My god, it is 21 days average.Control group women 40, age 23-34 Sui, average age 29.1 years old, the course of disease most short person 20 days, most elder 28 My god, it is 25 days average.The course of disease for the treatment of group and control group case, degrees of symptoms are basically identical, no significant difference, have comparable Property.
2nd, therapeutic scheme:
Chinese medicine composition (embodiment 1-3) of the present invention is taken by treatment group, takes orally, one portion per day, point takes for each 1 time sooner or later;3 It is 1 course for the treatment of, 1 course for the treatment of of the lighter, 2 courses for the treatment of of severe one.Control group takes CuiRu KeLi, and by specification is taken.During medication Daily observation cesarean lactation situation, during which lactation amount normally can withdrawal, statistical analysis is carried out to result after a week.
3rd, efficacy determination:
(1) cure:Breast without distending pain, without enclosed mass, have rosy cheeks, spirit still, voice is loud and clear, and arteries and veins is strong, and sleep is normal, Galactosis amount recovers normal.
(2) it is effective:Patient's malaise symptoms mitigate, and galactosis amount increases.
(3) it is invalid:Symptom is without change.
Total effective rate=cure rate+obvious effective rate
4th, result:
Group Number of cases (a) Cure (a/%) Effective (a/%) Invalid (a/%) Total effective rate (%)
Embodiment 1 40 25/62.5% 15/37.5% 0/0% 100.0%
Embodiment 2 40 23/57.5% 15/37.5% 2/5.0% 95.0%
Embodiment 3 40 25/62.5% 14/35.0% 1/2.5% 97.5%
Control group 40 19/47.5% 14/35.0% 7/17.5% 82.5%
The result shows that the cure rate and total effective rate for the treatment of group are obviously higher than control group.Illustrate the Chinese medicine group of the present invention Puerpera lactagogue of the compound to the puerperium middle and later periods works well.
Model case is illustrated:
Case 1, Mr. Wang, female, 29 years old, Henan people from Xuchang.20 days postpartum, during which household was that it has been looked for much also without lower breast The recipe that stimulates the secretion of milk is eaten, as peanut trotter stews, gold carp soup etc., but all there is no effect, Chinese medicine of the present invention is taken, is taken orally, daily one Agent, point takes for each 1 time sooner or later, after taking 3 days, starts lactation, after taking 6 days, galactosis amount recovers normal.Follow-up one A month, puerpera's galactosis amount was normal.
Case 2, Lee, female, 28 years old, District, Xinyang Area, Henan Province people.5 days postpartum no lower breast, is stimulated the secretion of milk in hospital using gimmick, parallel port The medicine that hospital issues is taken, milk is still rare, and 20 days postpartum started to take Chinese medicine of the present invention, takes orally, one portion per day, point morning and evening Take for each 1 time, after taking 2 days, galactosis amount increases, and after taking 6 days, galactosis amount recovers normal.Follow-up one month, production Woman's galactosis amount is normal.
Case 3, poplar, female, 26 years old, Henan Zhumadian people.4 days postpartum added the recipe that stimulates the secretion of milk without lower breast, the oral tea that stimulates the secretion of milk, Such as gold carp soup, milk is still rare, and 16 days postpartum started to take Chinese medicine of the present invention, takes orally, one portion per day, point sooner or later each 1 clothes With after taking 3 days, galactosis amount increases, and after taking 6 days, galactosis amount recovers normal.Follow-up one month, puerpera's milk Secretory volume is normal.

Claims (8)

1. a kind of Chinese medicine composition suitable for the puerpera's lactagogue of puerperium middle and later periods, it is characterised in that including following material medicine:River Rhizome of chuanxiong 5-15g, profound Hu 5-15g, stem pith of the rice-paper plant 5-15g, safflower 5-15g, dried orange peel 5-15g, radix glycyrrhizae 5-15g, rhizoma cyperi 5-15g, motherwort 10- 15g, fennel seeds 5-15g, hawthorn 20-30g, Radix Rhapontici seu Radix Echinopsis 20-25g, Angelica sinensis 5-8g, pangolin 20-40g, Radix Codonopsis 20-25g, radix astragali 10-20g, Radix Paeoniae Alba 10-20g, seed of cowherb 20-30g.
2. Chinese medicine composition according to claim 1, it is characterised in that including following material medicine:Ligusticum wallichii 5g, profound Hu 5g, stem pith of the rice-paper plant 5g, safflower 5g, dried orange peel 5g, radix glycyrrhizae 5g, rhizoma cyperi 5g, motherwort 10g, fennel seeds 5g, hawthorn 20g, Radix Rhapontici seu Radix Echinopsis 20g, Angelica sinensis 5g, pangolin 20g, Radix Codonopsis 20g, radix astragali 10g, Radix Paeoniae Alba 10g, seed of cowherb 20g.
3. Chinese medicine composition according to claim 1, it is characterised in that including following material medicine:Ligusticum wallichii 10g, profound Hu 10g, stem pith of the rice-paper plant 10g, safflower 10g, dried orange peel 10g, radix glycyrrhizae 10g, rhizoma cyperi 10g, motherwort 12g, fennel seeds 10g, hawthorn 25g, Radix Rhapontici seu Radix Echinopsis 22g, Angelica sinensis 6g, pangolin 30g, Radix Codonopsis 22g, radix astragali 15g, Radix Paeoniae Alba 15g, seed of cowherb 25g.
4. Chinese medicine composition according to claim 1, it is characterised in that including following material medicine:Ligusticum wallichii 15g, profound Hu 15g, stem pith of the rice-paper plant 15g, safflower 15g, dried orange peel 15g, radix glycyrrhizae 15g, rhizoma cyperi 15g, motherwort 15g, fennel seeds 15g, hawthorn 30g, Radix Rhapontici seu Radix Echinopsis 25g, Angelica sinensis 8g, pangolin 40g, Radix Codonopsis 25g, radix astragali 20g, Radix Paeoniae Alba 20g, seed of cowherb 30g.
It is 5. a kind of such as the preparation method of claim 1-4 any one of them Chinese medicine compositions, it is characterised in that including following step Suddenly:
(1) each material medicine is weighed by weight, is mixed, the water decoction of 10-15 times of addition mixed material drug weight 2-3 times, often Secondary 1-1.5h, merges decocting liquid, freezes, and Chinese medicine freeze-dried powder is made;
(2) biofermentation is used, Chinese medicine freeze-dried powder is seeded in the mixed bacteria liquid of 10-20 times of weight, sealed fermenting 30-50h, The mixed bacteria liquid includes:Bacillus subtilis 2 × 108Cfu/mL, Lactobacillus casei 3 × 108Cfu/mL, lactobacillus plantarum 2 ×108Cfu/mL, bifidobacterium breve 1 × 108Cfu/mL, saccharomycete 1 × 108cfu/mL;
(3) by zymotic fluid after filtering, it is canned to obtain the final product.
It is 6. a kind of such as the preparation method of claim 1-4 any one of them Chinese medicine compositions, it is characterised in that to weigh by weight Each material medicine, mixing, the water for adding 10-15 times of mixed material drug weight decoct 2-3 times, each 1-1.5h, merge decocting Liquid.
It is 7. a kind of such as the preparation method of claim 1-4 any one of them Chinese medicine compositions, it is characterised in that including following step Suddenly:
(1) Ligusticum wallichii, profound Hu, the stem pith of the rice-paper plant, safflower, dried orange peel are weighed by weight, is mixed, and add the body of 5-15 times of mixed material drug weight The ethanol of product concentration 90%, refluxing extraction 2-3 times under the conditions of 70-80 DEG C, each 1-1.5h, filtering, merging filtrate is through decompression Ethanol is recycled to no alcohol taste, and is condensed into the extractum A that relative density at 60 DEG C is 1.10-1.12;
(2) radix glycyrrhizae, rhizoma cyperi, motherwort, fennel seeds, hawthorn, Radix Rhapontici seu Radix Echinopsis, Angelica sinensis, Radix Codonopsis, radix astragali, Radix Paeoniae Alba, Wang Buliu are weighed by weight OK, mix, the water for adding 10-15 times of mixed material drug weight decocts 2-3 times, each 1-1.5h, filtering, and merging filtrate is simultaneously dense Shorten the medicinal extract B that relative density at 80 DEG C is 1.20-1.30 into;
(3) 100 mesh sieves are crossed after pangolin is crushed, it is spare;
(4) extractum A, medicinal extract B are uniformly mixed, concentrate, be dried to dry extract, crushed, and the mixing of pangolin powder, then add auxiliary Material, remixes uniformly, pelletizes, dry, to obtain the final product.
8. preparation method according to claim 7, it is characterised in that the auxiliary material is starch, dextrin or white sugar, dosage For the 20-30% of material medicine gross weight.
CN201810118939.6A 2018-02-06 2018-02-06 It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof Pending CN108030851A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810118939.6A CN108030851A (en) 2018-02-06 2018-02-06 It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810118939.6A CN108030851A (en) 2018-02-06 2018-02-06 It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108030851A true CN108030851A (en) 2018-05-15

Family

ID=62096721

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810118939.6A Pending CN108030851A (en) 2018-02-06 2018-02-06 It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108030851A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103893462A (en) * 2014-03-25 2014-07-02 南京信息工程大学 Chinese medicinal composition and effervescent tablet for assisting in promoting maternal lactation
CN104258334A (en) * 2014-09-25 2015-01-07 余军辉 Warming and nourishing medicine for women after delivery

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103893462A (en) * 2014-03-25 2014-07-02 南京信息工程大学 Chinese medicinal composition and effervescent tablet for assisting in promoting maternal lactation
CN104258334A (en) * 2014-09-25 2015-01-07 余军辉 Warming and nourishing medicine for women after delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
阴法岱等: "神奇通乳汤治疗产后缺乳160例", 《吉林中医药》 *
马培江等: "自拟通乳生化汤治疗产后缺乳30例", 《广西中医药》 *

Similar Documents

Publication Publication Date Title
CN102048933B (en) Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN101502582B (en) Composition for eliminating stagnation and promoting lactation and preparation method thereof
CN103301436B (en) Medicine for loosing weight and reducing fat
CN102988870A (en) Oral liquid for treating diseases of liver, gall, stomach and intestinal canal
CN104288651A (en) Medicine for treating postpartum hypogalactia and preparation method thereof
CN103689559A (en) Health-preserving health food formula beneficial for improving gastrointestinal functions and preparation method thereof
CN104784648A (en) Traditional Chinese medicine preparation for anorexia and preparation method of traditional Chinese medicine preparation
CN104042891A (en) Traditional Chinese medicine (TCM) composition for relieving constipation of puerperae and preparation method thereof
CN105876710A (en) Antiaging selenium-enriched purple yam herbal jelly and making method thereof
CN104673597A (en) Multifunctional health preserving liquor and production method thereof
CN107998366A (en) It is a kind of suitable for Chinese medicine composition of puerpera's lactagogue at initial stage in postpartum and preparation method thereof
CN106421432A (en) Traditional Chinese medicine for treating aged body deficiency syndrome and delaying senescence
CN106072656A (en) A kind of additive-free prevention and alleviate the health food of dysmenorrhea and production method thereof
CN105381424A (en) Traditional Chinese medicine for detoxifying human viscera and preparation method of traditional Chinese medicine
CN104547733B (en) A kind of Chinese medicine for receiving leukorrhea
CN104906511A (en) Traditional Chinese medicine preparation for reflux esophagitis and preparation method of traditional Chinese medicine preparation
CN105079703A (en) Medicine composition for treating infant spleen deficiency type diarrhea and preparation method thereof
CN104984237A (en) Traditional Chinese medicine composition and preparation method
CN104771585A (en) Traditional Chinese medicine composition for treating acute nephritis and preparation method thereof
CN104840688A (en) Health-maintaining soup capable of promoting breast milk secretion and preparation method of health-maintaining soup
CN108030851A (en) It is a kind of suitable for Chinese medicine composition of puerperium middle and later periods puerpera's lactagogue and preparation method thereof
CN107281414A (en) A kind of dietic medicinal tea and preparation method
CN105288502A (en) Medicated porridge with weight loss and slimming efficacy and preparation method thereof
CN104998131A (en) Composition for promoting healing of injured bone and preparation method thereof
CN104940777A (en) Electuary capable of treating liver-yang hyperactivity and spleen weakness type diarrhea during menstruation and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20190412

Address after: 450000 Zhengzhou Free Trade Test Zone, Zhengzhou City, Henan Province (Zhengdong). 907, 9th Floor, Building C, East East Ruyi Road, South Dongfeng Road, East Ruyi Road

Applicant after: Diguo Biotechnology Co., Ltd.

Address before: 450000 East Wind South Road and Ruyi West Road, Zhengdong New District, Zhengzhou City, Henan Province

Applicant before: Henan Di Guo science and Technology Development Co., Ltd.

TA01 Transfer of patent application right
RJ01 Rejection of invention patent application after publication

Application publication date: 20180515

RJ01 Rejection of invention patent application after publication