CN108013470A - Adjust the health-care chewable tablet and its preparation process of immunity - Google Patents
Adjust the health-care chewable tablet and its preparation process of immunity Download PDFInfo
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- CN108013470A CN108013470A CN201711315195.9A CN201711315195A CN108013470A CN 108013470 A CN108013470 A CN 108013470A CN 201711315195 A CN201711315195 A CN 201711315195A CN 108013470 A CN108013470 A CN 108013470A
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- 239000007910 chewable tablet Substances 0.000 title claims abstract description 46
- 230000036039 immunity Effects 0.000 title claims abstract description 39
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000843 powder Substances 0.000 claims abstract description 39
- 239000000463 material Substances 0.000 claims abstract description 33
- 239000004615 ingredient Substances 0.000 claims abstract description 25
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 18
- 241001164374 Calyx Species 0.000 claims abstract description 18
- 235000011511 Diospyros Nutrition 0.000 claims abstract description 18
- 244000236655 Diospyros kaki Species 0.000 claims abstract description 18
- 240000005979 Hordeum vulgare Species 0.000 claims abstract description 18
- 235000007340 Hordeum vulgare Nutrition 0.000 claims abstract description 18
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 18
- 241000432824 Asparagus densiflorus Species 0.000 claims abstract description 17
- 241000208688 Eucommia Species 0.000 claims abstract description 17
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 17
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 17
- 240000008669 Hedera helix Species 0.000 claims abstract description 17
- 240000000249 Morus alba Species 0.000 claims abstract description 17
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 17
- 241000124033 Salix Species 0.000 claims abstract description 17
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 17
- 210000000582 semen Anatomy 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000002131 composite material Substances 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 14
- 239000006228 supernatant Substances 0.000 claims description 14
- 238000001694 spray drying Methods 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 238000000748 compression moulding Methods 0.000 claims description 8
- 239000003826 tablet Substances 0.000 claims description 8
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 7
- 239000008116 calcium stearate Substances 0.000 claims description 7
- 235000013539 calcium stearate Nutrition 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
- 239000003595 mist Substances 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 208000033065 inborn errors of immunity Diseases 0.000 abstract description 4
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
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- 210000000936 intestine Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
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- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
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- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
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- 230000009471 action Effects 0.000 description 1
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- 238000006243 chemical reaction Methods 0.000 description 1
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- 230000008260 defense mechanism Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides the health-care chewable tablet and its preparation process for adjusting immunity, it is prepared by major ingredient and auxiliary material, and wherein major ingredient includes the component of following parts by weight：14 22 parts of blue or green money willow, 5 13 parts of stamen nelumbini, 29 parts of pollen pini, 49 parts of barley seedling powder, 16 parts of mulberry fruit, 36 parts of cape jasmine, 28 parts of Semen Lablab Album, 37 parts of Divine Comedy, 39 parts of Chinese medical extract；The Chinese medical extract is prepared into by peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell.Health-care chewable tablet prepared by the present invention has the effect of notable to the patient of hypoimmunity, and without excessive immune and allergic reaction.The chewable tablets carries and easy to use, performance drug effect synergistic by the proportioning of component, can be while immunity of organisms is adjusted, and the resistivity of excitating organism itself, improves body constitution, build up one's resistance to disease, can effectively recover the function of body itself.
Description
Technical field
The invention belongs to health product technology field, and in particular to adjust the health-care chewable tablet and its preparation process of immunity.
Background technology
Chewable tablets be one kind can put in oral cavity chew after swallow, also can contain to suck and dissolve under posterior phraynx, in the gastrointestinal tract play make
The tablet for playing general action is absorbed with or through intestines and stomach.Chewable tablets adds flavouring, good mouthfeel.It can swallow, chew, contain
Suck or taken after water-dispersible, from time, the limitation in place, under water deficit conditions also can medication on time, it is convenient to take,
Especially suitable for child, old man, apoplexy, dysphagia or the poor patient of gastrointestinal function, burden of the medicine to intestines and stomach is reduced,
Wide application of the crowd；Chewable tablets is because through chewing under posterior phraynx, without disintegrating procedue, through chewing rear surface product increase, promoting medicine and existing
Internal dissolving and absorption, dissolution is rapid, absorbs the bioavilability that soon, can improve medicine；It is above-mentioned special due to chewable tablets
Advantage, the purposes of chewable tablets are just more and more paid attention to.
Immunity is the defense mechanism of human body itself, is human bioequivalence and any foreign matter of the external intrusion of elimination（It is viral, thin
Bacterium etc.）；Handle aging, damage, death, the own cells of denaturation and identification and processing vivo mutations cell and virus infection is thin
The ability of born of the same parents.As urban stresses, irregular, environmental pollution etc. of living cause modern's immunity gradually low.If body
Immune system cannot normally play protective effect, in the case, easily cause the various infection such as bacterium, virus, fungi；When
When immune function of human body is lacked of proper care or immune system is unsound, flu, asthma, tonsillitis, pneumonia, diarrhea etc. disease can be caused
Disease, and it is sick after generally require longer time and could recover.If things go on like this, body consumption has been aggravated, it is also possible to induce weight
Big disease.Modern medical science finds that immunocyte decline is also the one of the major reasons of aging.Thus, a kind of energy is developed
The health-care chewable tablet for enough adjusting immunity of organisms and activation body immune system function has a good application prospect.
The content of the invention
For this reason, the present invention provides the health-care chewable tablet and its preparation process for adjusting immunity, solve in the prior art at least
A kind of technical problem.
For this reason, the present invention provides the health-care chewable tablet for adjusting immunity, it is prepared by major ingredient and auxiliary material, wherein major ingredient
Include the component of following parts by weight：14-22 parts of blue or green money willow, 5-13 parts of stamen nelumbini, 2-9 parts of pollen pini, 4-9 parts of barley seedling powder, mulberry fruit
1-6 parts sub-, 3-6 parts of cape jasmine, 2-8 parts of Semen Lablab Album, 3-7 parts of Divine Comedy, 3-9 parts of Chinese medical extract；
The Chinese medical extract is prepared into by peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell；
It is 1 that the auxiliary material, which includes weight ratio,:0.6-1.4:0.2-0.5 hydroxypropyl methylcelluloses, calcium stearate and diatom micro mist.
According to embodiment of the present invention, wherein, the mass ratio of the major ingredient and auxiliary material is 2.6-5.5:1.
According to embodiment of the present invention, wherein, the auxiliary material further includes sweetener and/or acid.
According to embodiment of the present invention, wherein, the Chinese medical extract is by for 1:0.2-0.6:0.4-1.1:
0.7-1.3:0.6-1.54:0.3-0.7:0.5-1.4:0.6-1:0.4-0.7 mass than peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern,
Radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into.
According to embodiment of the present invention, wherein, major ingredient includes the component of following parts by weight：16-21 parts of blue or green money willow,
7-12 parts of stamen nelumbini, 2.6-7 parts of pollen pini, 4.5-8 parts of barley seedling powder, 1.8-5 parts of mulberry fruit, 3.4-5.4 parts of cape jasmine, Semen Lablab Album
2.6-7.3 parts, 3.7-6.2 parts of Divine Comedy, 3.5-8 parts of Chinese medical extract.
For this reason, the present invention provides the preparation process for the health-care chewable tablet for adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, are subsequently placed in
In the 60-80wt.% ethanol solutions of 10-22 times of parts by weight, in 1.6-2.4MPa, 90-130 DEG C extract 1-2h, stood after extraction to
It is layered, takes supernatant；By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Obtain composite powder；
Above-mentioned composite powder is placed in compression molding on tablet press machine, that is, the health-care chewable tablet for adjusting immunity is made.
According to embodiment of the present invention, wherein, the condition of the compression molding is：Pressure size is 1.9-
3.7KPa, tabletting time are 3-8s.
According to embodiment of the present invention, wherein, the condition of the spray drying is：Spray dryer into wind-warm syndrome
Spend for 50-65 DEG C, leaving air temp is 70-90 DEG C.
Beneficial effects of the present invention are：
Health-care chewable tablet prepared by the present invention has the effect of notable to the patient of hypoimmunity, and without excessive immune and mistake
Quick reaction.By each embodiment and comparative example relatively, component proportion and the component compatibility combination of chewable tablets are to adjusting
Immunity has certain synergistic function.The chewable tablets carries and easy to use, hair synergistic by the proportioning of component
Drug effect is waved, can be while immunity of organisms be adjusted, the resistivity of excitating organism itself, improves body constitution, increase resistance
Power, can effectively recover the function of body itself.
Embodiment
With reference to embodiment, the present invention is described in further detail.Following embodiments are used to illustrate the present invention, but not
For limiting the scope of the invention.
Embodiment 1
The health-care chewable tablet of immunity is adjusted, it is prepared by major ingredient and auxiliary material, and the mass ratio of the major ingredient and auxiliary material is
2.6:1.Wherein major ingredient includes the component of following parts by weight：14 parts of blue or green money willow, 5 parts of stamen nelumbini, 2 parts of pollen pini, 4 parts of barley seedling powder,
1 part of mulberry fruit, 3 parts of cape jasmine, 2 parts of Semen Lablab Album, 3 parts of Divine Comedy, 3 parts of Chinese medical extract；
The Chinese medical extract is by for 1:0.2:0.4:0.7:0.6:0.3:0.5:0.6:0.4 mass than peach kernel, fushen, trigone,
Radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into；
It is 1 that the auxiliary material, which includes weight ratio,:0.6:0.2 hydroxypropyl methylcellulose, calcium stearate and diatom micro mist.The auxiliary material also wraps
Include sweetener.
The preparation process of the health-care chewable tablet of above-mentioned adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, is subsequently placed in 10
In the 60wt.% ethanol solutions of times parts by weight, in 1.6MPa, 90 DEG C of extraction 1h, stood after extraction to being layered, take supernatant；
By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Composite powder is obtained, wherein the condition of the spray drying is：The inlet air temperature of spray dryer is 50 DEG C, leaving air temp 70
℃；
Above-mentioned composite powder is placed in compression molding on tablet press machine, its pressure forming condition is：Pressure size is 1.9KPa, during tabletting
Between be 3s, that is, be made adjust immunity health-care chewable tablet.
Embodiment 2
The health-care chewable tablet of immunity is adjusted, it is prepared by major ingredient and auxiliary material, and the mass ratio of the major ingredient and auxiliary material is
5.5:1.Wherein major ingredient includes the component of following parts by weight：22 parts of blue or green money willow, 13 parts of stamen nelumbini, 9 parts of pollen pini, 9 parts of barley seedling powder,
6 parts of mulberry fruit, 6 parts of cape jasmine, 8 parts of Semen Lablab Album, 7 parts of Divine Comedy, 9 parts of Chinese medical extract；
The Chinese medical extract is by for 1:0.6:1.1:1.3:1.54:0.7:1.4:1:0.7 mass is than peach kernel, fushen, trigone, sweet
Grass, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into；
It is 1 that the auxiliary material, which includes weight ratio,:1.4:0.5 hydroxypropyl methylcellulose, calcium stearate and diatom micro mist.The auxiliary material also wraps
Include sweetener and acid.
The preparation process of the health-care chewable tablet of above-mentioned adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, is subsequently placed in 22
In the 80wt.% ethanol solutions of times parts by weight, in 2.4MPa, 130 DEG C of extraction 2h, stood after extraction to being layered, take supernatant
Liquid；By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Composite powder is obtained, wherein the condition of the spray drying is：The inlet air temperature of spray dryer is 65 DEG C, leaving air temp 90
℃；
Above-mentioned composite powder is placed in compression molding on tablet press machine, its pressure forming condition is：Pressure size is 3.7KPa, during tabletting
Between be 8s, that is, be made adjust immunity health-care chewable tablet.
Embodiment 3
The health-care chewable tablet of immunity is adjusted, it is prepared by major ingredient and auxiliary material, and the mass ratio of the major ingredient and auxiliary material is 4:
1.Wherein major ingredient includes the component of following parts by weight：16 parts of blue or green money willow, 7 parts of stamen nelumbini, 2.6 parts of pollen pini, 4.5 parts of barley seedling powder,
1.8 parts of mulberry fruit, 3.4 parts of cape jasmine, 2.6 parts of Semen Lablab Album, 3.7 parts of Divine Comedy, 3.5 parts of Chinese medical extract；
The Chinese medical extract is by for 1:0.4:0.7:0.8:0.9:0.35:0.59:0.82:0.6 mass is than peach kernel, fushen, three
Rib, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into；
It is 1 that the auxiliary material, which includes weight ratio,:1.2:0.4 hydroxypropyl methylcellulose, calcium stearate and diatom micro mist.
The preparation process of the health-care chewable tablet of above-mentioned adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, is subsequently placed in 18
In the 70wt.% ethanol solutions of times parts by weight, in 2.2MPa, 120 DEG C of extraction 2h, stood after extraction to being layered, take supernatant
Liquid；By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Composite powder is obtained, wherein the condition of the spray drying is：The inlet air temperature of spray dryer is 58 DEG C, leaving air temp 80
℃；
Above-mentioned composite powder is placed in compression molding on tablet press machine, its pressure forming condition is：Pressure size is 2.5KPa, during tabletting
Between be 6s, that is, be made adjust immunity health-care chewable tablet.
Embodiment 4
The health-care chewable tablet of immunity is adjusted, it is prepared by major ingredient and auxiliary material, and the mass ratio of the major ingredient and auxiliary material is
4.6:1.Wherein major ingredient includes the component of following parts by weight：21 parts of blue or green money willow, 12 parts of stamen nelumbini, 7 parts of pollen pini, 8 parts of barley seedling powder,
5 parts of mulberry fruit, 5.4 parts of cape jasmine, 7.3 parts of Semen Lablab Album, 6.2 parts of Divine Comedy, 8 parts of Chinese medical extract；
The Chinese medical extract is by for 1:0.5:0.7:1.2:1:0.55:0.7:0.68:0.53 mass than peach kernel, fushen, trigone,
Radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into；
It is 1 that the auxiliary material, which includes weight ratio,:0.9:0.4 hydroxypropyl methylcellulose, calcium stearate and diatom micro mist.
The preparation process of the health-care chewable tablet of above-mentioned adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, is subsequently placed in 20
In the 75wt.% ethanol solutions of times parts by weight, in 2MPa, 110 DEG C of extraction 2h, stood after extraction to being layered, take supernatant；
By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Composite powder is obtained, wherein the condition of the spray drying is：The inlet air temperature of spray dryer is 60 DEG C, leaving air temp 85
℃；
Above-mentioned composite powder is placed in compression molding on tablet press machine, its pressure forming condition is：Pressure size is 2.8KPa, during tabletting
Between be 7s, that is, be made adjust immunity health-care chewable tablet.
Embodiment 5
The health-care chewable tablet of immunity is adjusted, it is prepared by major ingredient and auxiliary material, and the mass ratio of the major ingredient and auxiliary material is
4.7:1.Wherein major ingredient includes the component of following parts by weight：20 parts of blue or green money willow, 9 parts of stamen nelumbini, 6.3 parts of pollen pini, barley seedling powder 6.5
Part, 3.2 parts of mulberry fruit, 4 parts of cape jasmine, 5.8 parts of Semen Lablab Album, 4.6 parts of Divine Comedy, 5.2 parts of Chinese medical extract；
The Chinese medical extract is by for 1:0.5:0.7:0.8:1:0.4:0.9:0.8:0.5 mass is than peach kernel, fushen, trigone, sweet
Grass, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into；
It is 1 that the auxiliary material, which includes weight ratio,:1.2:0.4 hydroxypropyl methylcellulose, calcium stearate and diatom micro mist.
The preparation process of the health-care chewable tablet of above-mentioned adjusting immunity, including following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, is subsequently placed in 16
In the 75wt.% ethanol solutions of times parts by weight, in 2.2MPa, 120 DEG C of extraction 2h, stood after extraction to being layered, take supernatant
Liquid；By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Composite powder is obtained, wherein the condition of the spray drying is：The inlet air temperature of spray dryer is 58 DEG C, leaving air temp 85
℃；
Above-mentioned composite powder is placed in compression molding on tablet press machine, its pressure forming condition is：Pressure size is 3.2KPa, during tabletting
Between be 7s, that is, be made adjust immunity health-care chewable tablet.
Comparative example 1
This comparative example in place of the difference of embodiment 1 with being：Do not add Chinese medical extract.
Comparative example 2
This comparative example in place of the difference of embodiment 1 with being：Pollen pini, barley seedling powder, the calyx and receptacle of a persimmon and peach kernel are not added.
Performance test
100 people of volunteer of the right side of fifty hypoimmunity is randomly selected, it is random to divide equally 10 groups, a blank control group is set,
Remaining experimental group gives above example and the health-care chewable tablet obtained by comparative example respectively, one day 3, take orally 1 month, it is treated
It is as follows to imitate result：
| Effective/example | Recovery from illness/example | Invalid/example | |
| Embodiment 1 | 4 | 4 | 2 |
| Embodiment 2 | 3 | 5 | 2 |
| Embodiment 3 | 3 | 6 | 1 |
| Embodiment 4 | 2 | 7 | 1 |
| Embodiment 5 | 1 | 8 | 1 |
| Comparative example 1 | 3 | 3 | 4 |
| Comparative example 2 | 3 | 2 | 5 |
| Comparative example 3 | 3 | 3 | 4 |
| Comparative example 4 | 3 | 2 | 5 |
| Blank control | 0 | 0 | 10 |
From above test result, the health-care chewable tablet prepared by the present invention has significant treat to the patient of hypoimmunity
Effect, and without excessive immune and allergic reaction.By each embodiment and comparative example relatively, the component proportion and group of chewable tablets
The combination of distribution 5 has certain synergistic function to adjusting immunity.
Claims (8)
1. adjust immunity health-care chewable tablet, it is characterised in that it is prepared by major ingredient and auxiliary material, wherein major ingredient include with
The component of lower parts by weight：14-22 parts of blue or green money willow, 5-13 parts of stamen nelumbini, 2-9 parts of pollen pini, 4-9 parts of barley seedling powder, mulberry fruit 1-6
Part, 3-6 parts of cape jasmine, 2-8 parts of Semen Lablab Album, 3-7 parts of Divine Comedy, 3-9 parts of Chinese medical extract；
The Chinese medical extract is prepared into by peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell；
It is 1 that the auxiliary material, which includes weight ratio,:0.6-1.4:0.2-0.5 hydroxypropyl methylcelluloses, calcium stearate and diatom micro mist.
2. the health-care chewable tablet of immunity is adjusted as claimed in claim 1, it is characterised in that the quality of the major ingredient and auxiliary material
Than for 2.6-5.5:1.
3. the health-care chewable tablet of immunity is adjusted as claimed in claim 1, it is characterised in that the auxiliary material further includes sweetener
And/or acid.
4. the health-care chewable tablet of immunity is adjusted as claimed in claim 1, it is characterised in that the Chinese medical extract is by for 1:
0.2-0.6:0.4-1.1:0.7-1.3:0.6-1.54:0.3-0.7:0.5-1.4:0.6-1:0.4-0.7 mass is than peach kernel, Fu
God, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are prepared into.
5. the health-care chewable tablet of immunity is adjusted as claimed in claim 1, it is characterised in that major ingredient includes following parts by weight
Component：16-21 parts of blue or green money willow, 7-12 parts of stamen nelumbini, 2.6-7 parts of pollen pini, 4.5-8 parts of barley seedling powder, 1.8-5 parts of mulberry fruit, Cape jasmine
3.4-5.4 parts sub-, 2.6-7.3 parts of Semen Lablab Album, 3.7-6.2 parts of Divine Comedy, 3.5-8 parts of Chinese medical extract.
6. the preparation process of the health-care chewable tablet of the adjusting immunity as described in claim 1-5 is any, it is characterised in that including
Following preparation process：
By weight, blue or green money willow, stamen nelumbini, mulberry fruit, cape jasmine and Semen Lablab Album cleaned, clean and dry rear grinds, then
It is uniformly mixed with pollen pini, barley seedling powder, Divine Comedy, continues to be ground to 50-100 mesh, obtain mixed powder；
By weight, peach kernel, fushen, trigone, radix glycyrrhizae, asparagus fern, radix polygonati officinalis, the bark of eucommia, the calyx and receptacle of a persimmon and tortoiseshell are cleaned, are subsequently placed in
In the 60-80wt.% ethanol solutions of 10-22 times of parts by weight, in 1.6-2.4MPa, 90-130 DEG C extract 1-2h, stood after extraction to
It is layered, takes supernatant；By supernatant liquid filtering, stir evenly, be freeze-dried and be ground into fine powder, obtain Chinese medical extract；
Mixed powder will be stated and Chinese medical extract is uniformly mixed, then add auxiliary material and a small amount of ethanol, be uniformly mixed, spray drying,
Obtain composite powder；
Above-mentioned composite powder is placed in compression molding on tablet press machine, that is, the health-care chewable tablet for adjusting immunity is made.
7. as claimed in claim 6 adjust immunity health-care chewable tablet preparation process, it is characterised in that the tabletting into
The condition of type is：Pressure size is 1.9-3.7KPa, and the tabletting time is 3-8s.
8. the preparation process of the health-care chewable tablet of immunity is adjusted as claimed in claim 6, it is characterised in that the spraying is dry
Dry condition is：The inlet air temperature of spray dryer is 50-65 DEG C, and leaving air temp is 70-90 DEG C.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1635088A (en) * | 2004-10-13 | 2005-07-06 | 李富祥 | Dispense of hygienic medicated wine |
| CN101829187A (en) * | 2010-04-28 | 2010-09-15 | 广西壮族自治区药用植物园 | Preparation method of fruit-flavored cyclocarya paliurus chewable tablets |
| CN103947719A (en) * | 2014-03-25 | 2014-07-30 | 刘阿君 | Snow rice cakes for reducing fat and losing weight and preparation method thereof |
-
2017
- 2017-12-12 CN CN201711315195.9A patent/CN108013470A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1635088A (en) * | 2004-10-13 | 2005-07-06 | 李富祥 | Dispense of hygienic medicated wine |
| CN101829187A (en) * | 2010-04-28 | 2010-09-15 | 广西壮族自治区药用植物园 | Preparation method of fruit-flavored cyclocarya paliurus chewable tablets |
| CN103947719A (en) * | 2014-03-25 | 2014-07-30 | 刘阿君 | Snow rice cakes for reducing fat and losing weight and preparation method thereof |
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