CN107998347A - A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof - Google Patents
A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof Download PDFInfo
- Publication number
- CN107998347A CN107998347A CN201711158423.6A CN201711158423A CN107998347A CN 107998347 A CN107998347 A CN 107998347A CN 201711158423 A CN201711158423 A CN 201711158423A CN 107998347 A CN107998347 A CN 107998347A
- Authority
- CN
- China
- Prior art keywords
- buddhist nun
- promise buddhist
- disinfectant
- crhd
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof, the present invention relates to disinfection antibacterial agent, the disinfectant includes the raw material of following mass fraction：Promise Buddhist nun powder 10 40%, 0.5% ~ 1.2% citral, 0.8 ~ 1.5% eugenol, 5 ~ 15 aloe powders, 0.5 1.5% oil of ginger, 0.5 3% ethanol, remaining is deionized water solution.Present invention has the advantages that：Promise Buddhist nun, citral, eugenol, aloe powder and Nuo Ni powder are natural plant extracts in technical scheme, human skin are not damaged, pharmacologically then mutually promote, enriching yin clearing damp, antibiotic skin-care significant effect.Compared to common skin disinfectant, disinfectant provided by the invention has good osmosis, makes GG hEGF（EGF）, subcutaneous tissue, metabolic cycles enhancing, immune function improve.CRHD deionized waters and solution improve the dissipation ability to pathogenic microorganism, mucous membrane microorganism pathogenic bacteria, environmental-friendly, green non-pollution.
Description
Technical field
The present invention relates to disinfection antibacterial agent, more particularly to one kind to be based on CRHD activity concepts, is prepared with natural plants promise Buddhist nun
Skin care disinfection sanitizer.
Background technology
Current most of disinfection antibacterial agents contain the chemical substance for having toxic side effect to environment and human body.Chemical synthesis disappears
Toxic agent contains the harmful effect to human organ and environmental pollution and pollution, and long-time service chemical synthesis disinfectant products are not
Beneficial to health, and the resistance to the action of a drug, the drug resistance produced, destroyed immune system.Nuo Ni（Noni）Scientific name morinda citrifolia
（Morinfa citrfolia）.Nuo Ni is plant natural, nontoxic, rich in multiple nutritional components, has very high clinical practice
Value.In May, 2010 ministry of Health of China approval promise Buddhist nun pulp is new resource food, and China Hainan, Yunnan Nuo Ni planting bases are certainly
The series of products of main research and development enter market comprehensively.Domestic and foreign scholars are to the active ingredient of promise Buddhist nun and its laboratory of the mechanism of action
Number is it was demonstrated that there is the anthraquinone from promise Buddhist nun extraction especially strong quinone reductase to induce vigor.Nuo Ni has anticancer, adjusts siberian crabapple
System, suppresses tumour growth, anti-oxidant, anti-aging, eliminates free radical, anticancer and other effects.It must amino acid, dimension life containing human body
Element, mineral matter and a variety of physiologically active ingredients, it is obvious to treating a variety of disease effects, there is very high medicinal and health value.
The excellent antibacterial of promise Buddhist nun（Bacterium and fungi）Antiinflammation, is found at first.Anthraquinone compounds in promise Buddhist nun, L2 asperulosides and
The antibacterial activities such as alizarin can effectively prevent Pseudomonas aeruginosa, mycetozoan, staphylococcus aureus, rod bacterium, Escherichia coli, sand
The infection of the door bacterium such as bacterium and bacillus dysenteriae.Anthraquinone can dramatically increase glue thickness C-terminal before I types in the normal skin fibrocyte of people
Peptide and glucose, amine glycan content, suppress clostridiopetidase A（Matrix metalloprotease peptide）Expression and into dose dependent.In skin
Based on the I types and type III collagen of collagen, anthraquinone compounds in promise Buddhist nun by the biosynthesis of inducing cell epimatrix,
Play anti-inflammatory, antibacterial, crease-resistant, enriching yin clearing damp, skin care effect.Aloe powder（Gel）In the anthraquinones containing anti-microbial property into
Point.
CRHD（Based on human body " sense of taste conditioned reflex and health identification "）Structural system
“Conditional Reflex and Health Diagnostic based on taste”
Tested using the human body sense of taste to assess the structural system of human body health status, and obtained according to medicine and physiology promise prize
Person has found：" only small-micelle water could pass through 2 nanometers（nm）Human body cell ion channel, into nucleus and DNA, swash
Send out vitality, common pure water macromolecular mass can not be directly entered into the cell " discovery, prepared active water（Deionization
Water）.Ectoenzyme caused by mineral matter group in CRHD solution can effectively decompose the organic substance in thimerosal, and utilize release
The unique absorption property gone out promotes activation to optimize the beneficiating ingredients such as the skin care in disinfectant, disinfection, antibacterial, anti-inflammatory.
Environmentally friendly, antibacterial wide spectrum, quick-acting, bactericidal effect is lasting；Less toxic pair, enriching yin clearing damp, readily soluble water, infiltration by force,
It is free from extraneous odour, safe and simple, it has also become disinfecting skin-care class product market is preferred.
The content of the invention
The present invention provides a kind of optimization GG hEGF " CRHD " tissue and resists with environmentally friendly natural plants
Bacterium, skin care disinfectant.The present invention is special according to the activity of CRHD human bodies " identification of sense of taste conditioned reflex health " principle and CRHD solution
The effect of levying rational proportion, overcoming traditional antibiotic skin-care disinfectant deficiency, improves disinfectant and human body pathogenic microorganism is glued
The dissipation ability of film vitamin pathogenic bacteria, makes hEGF（EGF）And skin histology immune function obtain health it is excellent
Change.
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Nuo Ni
Powder 10-40%, 0.5% ~ 1.2% citral, 0.8 ~ 1.5% eugenol, 5 ~ 15 aloe powders, the oil of ginger of 0.5-1.5%, 0.5-
3% ethanol, remaining is deionized water solution.
Further, the deionized water solution is CRHD deionized water solutions.
A kind of preparation method of promise Buddhist nun's skin care disinfectant based on CRHD includes the following steps：（1）By citral and cloves
Phenol is sufficiently mixed, and obtains mixed liquor I；（2）Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, mixed
Close liquid II；（3）Promise Buddhist nun powder and aloe powder are mixed and added in deionized water, mixing is equal, obtains mixed liquor I II；（4）By mixed liquor
III and mixed liquor I I are uniformly mixed, and obtain promise Buddhist nun's skin care disinfectant.
Promise Buddhist nun's powder, is prepared using promise Buddhist nun fruit, containing abundant anti-oxidizing compounds, be can be used for cell maintenance, is reached
Cutaneous immunisation is strengthened in good metabolism and microcirculation, in the present case, help.
Citral is the smell brought for improving promise Buddhist nun's powder.
Eugenol has very strong sterilizing power, in the present case the host agent as disinfectant.
Oil of ginger, the smell except improving disinfectant provided by the invention, moreover it is possible to coordinate promise Buddhist nun's powder, improve the new old of skin
Metabolism and microcirculation, the disinfectant for being, more can skin cares while disinfection.
Aloe powder, and promise Buddhist nun powder coordinate, and improve skin texture.
Present invention has the advantages that：Promise Buddhist nun, citral, eugenol, aloe powder and Nuo Ni powder in technical scheme
Be natural plant extracts, human skin do not damaged, pharmacologically then mutually promote, enriching yin clearing damp, antibiotic skin-care effect
Fruit is notable.Compared to common skin disinfectant, disinfectant provided by the invention has good osmosis, makes one body surface
Skin growth factor（EGF）, subcutaneous tissue, metabolic cycles enhancing, immune function improve.CRHD deionized waters and solution improve pair
Pathogenic microorganism, the dissipation ability of mucous membrane microorganism pathogenic bacteria, environmental-friendly, green non-pollution.
Embodiment
Embodiment 1
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
20%, 0.8% citral, 1% eugenol, 10% aloe powder, 0.7% oil of ginger, 1% ethanol, remaining is water-soluble for deionization
Liquid.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor I；（2）
Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and aloe powder
Mixing is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed, obtained
Promise Buddhist nun's skin care disinfectant.
Embodiment 2
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
35%, 0.6% citral, 1.1% eugenol, 12% aloe powder, 1.5% oil of ginger, 1.8% ethanol, remaining is deionization
Aqueous solution.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor
I；（2）Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and reed
The mixing of luxuriant growth powder is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed,
Obtain promise Buddhist nun's skin care disinfectant.
Embodiment 3
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
30%, 1.2% citral, 1.2% eugenol, 8% aloe powder, 1% oil of ginger, 1.3% ethanol, remaining is water-soluble for deionization
Liquid.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor I；（2）
Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and aloe powder
Mixing is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed, obtained
Promise Buddhist nun's skin care disinfectant.
Embodiment 4
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
28%, 0.9% citral, 0.9% eugenol, 13% aloe powder, 1.8% oil of ginger, 1% ethanol, remaining is deionized water
Solution.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor I；
（2）Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and aloe
Powder mixing is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed, obtained
To promise Buddhist nun's skin care disinfectant.
Embodiment 5
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
25%, 1.2% citral, 1.3% eugenol, 14% aloe powder, 1.2% oil of ginger, 0.7% ethanol, remaining is deionization
Aqueous solution.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor
I；（2）Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and reed
The mixing of luxuriant growth powder is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed,
Obtain promise Buddhist nun's skin care disinfectant.
Embodiment 6
A kind of promise Buddhist nun's skin care disinfectant based on CRHD, the disinfectant include the raw material of following mass fraction：Promise Buddhist nun's powder
15%, 1.1% citral, 1.3% eugenol, 13% aloe powder, 1.3% oil of ginger, 1.8% ethanol, remaining is deionization
Aqueous solution.The disinfectant is prepared using following method：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor
I；（2）Added in mixture I in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and reed
The mixing of luxuriant growth powder is added in deionized water, and mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed,
Obtain promise Buddhist nun's skin care disinfectant.
Disinfectant provided by the invention to skin bacterium colony killing rate more than 98%, and sterilization while, maintain skin
Skin.
Claims (3)
1. a kind of promise Buddhist nun's skin care disinfectant based on CRHD, it is characterised in that the disinfectant includes following mass fraction
Raw material：Promise Buddhist nun's powder 10-40%, 0.5% ~ 1.2% citral, 0.8 ~ 1.5% eugenol, 5 ~ 15% aloe powders, the life of 0.5-1.5%
Ginger oil, the ethanol of 0.5-2%, remaining is deionized water solution.
2. promise Buddhist nun's skin care disinfectant based on CRHD as claimed in claim 1, it is characterised in that the deionized water solution
It is water-soluble for CRHD deionizations.
3. a kind of preparation method of promise Buddhist nun's skin care disinfectant based on CRHD as claimed in claim 1, it is characterised in that described
Preparation method include the following steps：（1）Citral and eugenol are sufficiently mixed, obtain mixed liquor I；（2）Add in mixture I
Enter in oil of ginger, be uniformly mixed, continuously add ethanol, obtain mixed liquor I I；（3）By promise Buddhist nun powder and aloe powder mixing addition go from
In sub- water, mixing is equal, obtains mixed liquor I II；（4）Mixed liquor I II and mixed liquor I I are uniformly mixed, obtain promise Buddhist nun skin care disinfection
Agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711158423.6A CN107998347A (en) | 2017-11-20 | 2017-11-20 | A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711158423.6A CN107998347A (en) | 2017-11-20 | 2017-11-20 | A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107998347A true CN107998347A (en) | 2018-05-08 |
Family
ID=62052908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711158423.6A Pending CN107998347A (en) | 2017-11-20 | 2017-11-20 | A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107998347A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6869623B2 (en) * | 2003-07-21 | 2005-03-22 | Manuel Viamonte, Jr. | Non-toxic mucosal disinfectant containing isopropyl alcohol, sesame oil, aloe, and lemon oil |
| CN104055723A (en) * | 2014-06-25 | 2014-09-24 | 蓝星（成都）新材料有限公司 | Natural leave-on sleeping mask |
| CN106492152A (en) * | 2016-11-02 | 2017-03-15 | 陈厚兵 | A kind of skin surface disinfecting anti inflammatory agent and preparation method thereof |
-
2017
- 2017-11-20 CN CN201711158423.6A patent/CN107998347A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6869623B2 (en) * | 2003-07-21 | 2005-03-22 | Manuel Viamonte, Jr. | Non-toxic mucosal disinfectant containing isopropyl alcohol, sesame oil, aloe, and lemon oil |
| CN104055723A (en) * | 2014-06-25 | 2014-09-24 | 蓝星（成都）新材料有限公司 | Natural leave-on sleeping mask |
| CN106492152A (en) * | 2016-11-02 | 2017-03-15 | 陈厚兵 | A kind of skin surface disinfecting anti inflammatory agent and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Morales-Ubaldo et al. | Bovine mastitis, a worldwide impact disease: prevalence, antimicrobial resistance, and viable alternative approaches | |
| Negahdari et al. | Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study | |
| KR20160079473A (en) | Preparation method of cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component | |
| EP2404502A2 (en) | Compositions containing pyrrolidone carboxylic acid (PCA) and metallic salts | |
| CN103977155A (en) | Cleaning-free compound hand sanitizer and preparation method thereof | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| CN111493097A (en) | Collective disinfectant for inhibiting viruses and pathogenic bacteria and preparation method thereof | |
| CN108635378A (en) | A kind of mouth sprays and preparation method thereof for common oral health maintenance | |
| Rodriguez-Garcia et al. | Development and in vitro evaluation of biopolymers as a delivery system against periodontopathogen microorganisms | |
| Nwaokorie et al. | Antimicrobial activities of Garcinia kola on oral Fusobacterium nucleatum and biofilm | |
| WO2021022562A1 (en) | Pure natural compound essential oil having broad-spectrum bactericidal activity and preparation and application thereof | |
| CN106511114A (en) | Broad spectrum bactericidal pure natural orange extract essence and preparation method thereof | |
| Siddique et al. | Antimicrobial efficacy of garlic-lemon in comparison with sodium hypochlorite against E. faecalis | |
| KR20160079459A (en) | Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component | |
| CN101874844A (en) | Citrus extract bacteriostat, production process and application thereof | |
| CN101744000A (en) | Bactericidal agent and manufacturing method thereof | |
| CN107998347A (en) | A kind of promise Buddhist nun's skin care disinfectant based on CRHD and preparation method thereof | |
| Chatterjee et al. | Antimicrobial efficacy of some medicinal plant extract against Streptococcus mutans causing dental caries | |
| KR102252009B1 (en) | Antiviral or antibacterial composition containing extracts of Torreya nucifera leaf | |
| CN104904753A (en) | Efficient disinfectant and preparation method thereof | |
| JP2020070265A (en) | Method for improving skin condition, method for designing skin condition improving agent, and skin condition improving agent | |
| CN115211438A (en) | Bactericidal composition containing traditional Chinese medicine extract and silver ions and application thereof | |
| Al-Salihi et al. | Activity of Some Disinfectants, Detergents and Essential Oils on Growth of the yeast Candida albicans | |
| CN103736139B (en) | A kind of natural antibiotic antiseptic and processing technology thereof and hygienic article | |
| CN111214409A (en) | No-clean disinfectant and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180508 |