CN107998290A - 一种铁皮石斛复方含片及其制备工艺 - Google Patents
一种铁皮石斛复方含片及其制备工艺 Download PDFInfo
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- CN107998290A CN107998290A CN201711480894.9A CN201711480894A CN107998290A CN 107998290 A CN107998290 A CN 107998290A CN 201711480894 A CN201711480894 A CN 201711480894A CN 107998290 A CN107998290 A CN 107998290A
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- dendrobium candidum
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- american ginseng
- ganoderma lucidum
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Abstract
本发明公开了一种铁皮石斛复方含片及其制备方法，其原料组分包括：铁皮石斛、西洋参、灵芝、填充剂、粘合剂、酸味剂、润滑剂。首先将去皮的铁皮石斛茎干压榨成渣状，再经煎煮、过滤、减压浓缩、干燥，得铁皮石斛提取物；分别将西洋参和灵芝粉碎至细粒，再依次置于弱碱和弱酸中浸泡，再洗涤、过滤、干燥、气流粉碎，得西洋参破壁粉和灵芝破壁粉；再将铁皮石斛提取物、西洋参破壁粉、灵芝破壁粉和填充剂、粘合剂、酸味剂、润滑剂混合均匀，再烘干，压片、包装，得到成品。本发明产品通过合理的配伍，保存原料中的有效成分，具有增强体质功能；使用和携带方便；制备工艺合理，适合工业化生产。
Description
技术领域
本发明属于铁皮石斛保健制品领域，具体涉及一种利用铁皮石斛、西洋参、灵芝制备复方含片的方法。
背景技术
铁皮石斛为兰科石斛属的多年生附生草本植物，又名铁皮枫斗、耳环石斛、铁皮兰、黑节草等。铁皮石斛自古以来就拥有“药中黄金”之美誉，道家医学经典《道藏》将铁皮石斛列为“九大仙草”之首，民间称其为“救命仙草”。铁皮石斛主要药用成分是多糖、生物碱、氨基酸、酚类和许多对人体有益的微量元素。据现代研究表明铁皮石斛对咽喉疾病、肠胃疾病、白内障、心血管等疾病有显著疗效，具有增强免疫力、提高机体免疫机能、抗衰老、抗疲劳、养颜美发等功效。
西洋参是五加科人参属多年生草木植物，别名花旗参、洋参、西洋人参等。西洋参中主要成分为西洋参皂苷，西洋参皂苷是西洋参中最主要的有效成分之一，也是生理活性最显著的物质吗，对增强中枢神经系统功能、保护心血管系统、提高免疫力、促进血液活力、治疗糖尿病都有较高的保健价值。
灵芝又称灵芝草，是担子菌纲多孔菌科，具有扶正固本等功效，被《本经》称为上品。灵芝作为拥有数千年药用历史的中国传统珍贵药材，具备很高的药用价值，经过科研机构数十年的现代药理学研究证实，灵芝对于增强人体免疫力，调节血糖，控制血压，辅助肿瘤放化疗，保肝护肝，促进睡眠等方面均具有显著疗效。
含片指含于口腔内缓慢溶解的压制片，尤其适合老人、小孩、中风患者、吞服困难及胃肠功能差的患者，现有技术中，存在铁皮石斛含片成分单一，保健效果不好等不足。
发明内容
为了克服铁皮石斛含片成分单一，保健效果不好等缺点，本发明提供一种铁皮石斛复方含片，该铁皮石斛复方含片各原料的重量份数如下：
铁皮石斛 30-60份
西洋参 10-20份
灵芝 10-20份
填充剂 200-300份
粘合剂 50-100份
酸味剂 1-5份
润滑剂 1-5份。
所述的填充剂为：淀粉，糊精，蔗糖，微晶纤维素，乳糖，变性淀粉，预胶化淀粉，葡萄糖，甘露糖，木糖醇，超级羧甲基淀粉钠、羧甲基淀粉钠、低取代羟丙基纤维素、交联聚乙烯吡咯烷酮、交联羧甲基纤维素钠、低取代羟丙纤维素的一种或者多种混合物。
所述的粘合剂为：阿拉伯胶、明胶、甲基纤维素、羧甲基纤维素、乙基纤维素、聚乙烯醇、聚乙二醇、聚乙烯毗咯烷酮、黄原胶的一种或者多种混合物。
所述的酸味剂为：柠檬酸或抗坏血酸的一种或者两者混合物。
所述的润滑剂为：硬脂酸镁，滑石粉的一种或者两者混合物。
本发明还提上供述铁皮石斛复方含片的制备方法，该制备方法具体包括如下步骤：
S1:铁皮石斛提取物的制备：
(1)取铁皮石斛，除去枝叶和茎干表皮；
(2)将去皮的铁皮石斛茎干切成段，再将其充分压榨至渣状；
(3)用4-6倍量水进行煎煮，过滤收取滤液，再加入清水反复煎煮2-3次，每次煎煮1-2h；
(4)合并滤液，并在温度为60-80℃下进行减压浓缩，得铁皮石斛浓缩物；
(5)将铁皮石斛浓缩物在温度为70-80℃干燥至颗粒粉状，得铁皮石斛提取物，备用；
S2:西洋参破壁粉制备：
(1)选取西洋参，洗净去杂质，晾干；
(2)将晾干的西洋参放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300-500目的细粒；
(3)将细粒置于弱碱溶液中浸泡5-10h，加入弱酸将pH值调至小于7，浸泡5-10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到800-1000目的粉末，收集成品粉末即为西洋参破壁粉；
S3:灵芝破壁粉的制备：
(1)选取灵芝，洗净去杂质，晾干；
(2)将晾干的灵芝放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300-500目的细粒；
(3)将细粒置于稀碱溶液中浸泡5-10h，加入弱酸将pH值调至小于7，浸泡5-10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到800-1000目的粉末，收集成品粉末即为灵芝破壁粉；
S4:制片：
(1)将S1制备的铁皮石斛提取物、S2制备的西洋参破壁粉、S3制备的灵芝破壁粉和填充剂、粘合剂、酸味剂、润滑剂按重量比充分混合均匀；
(2)再在50-60℃烘干，制备含水量低于5％；
(3)再进行压片、铝塑压板、包装，得到成品。
优先地，所述的S2步骤(3)中弱碱为醋酸钠溶液，弱酸为醋酸溶液。
优先地，所述的S3步骤(3)中，所述的弱酸为醋酸溶液，弱酸为醋酸溶液。
与现有技术相比，本发明的有益效果是：
1.本发明产品通过合理的配伍，保存原料中的有效成分，具有增强免疫力、增强体质等功能；2.本发明产品体积小，使用和携带方便；3.本发明产品制备工艺合理，适合工业化生产。
具体实施方式
以下结合实施例对本发明作进一步具体描述。应该指出，以下具体说明都是例示性的，旨在对本发明提供进一步的说明。除非另有说明，本发明使用的所有科学和技术术语具有与本发明所属技术领域人员通常理解的相同含义。
实施例一：
S1:铁皮石斛提取物的制备：
(1)将铁皮石斛除去枝叶和茎干表皮；
(2)取300g去皮的铁皮石斛茎干，切成段，将其充分压榨至渣状；
(3)用4倍重量的水进行煎煮，过滤收取滤液，再加入清水反复煎煮2次，每次煎煮1h；
(4)合并滤液，并在温度为60℃下进行减压浓缩，得铁皮石斛浓缩物；
(5)将铁皮石斛浓缩物在温度为70℃干燥至颗粒粉状，得铁皮石斛提取物，备用；
S2:西洋参破壁粉制备：
(1)选取西洋参，洗净去杂质，晾干；
(2)取100g晾干的西洋参放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡5h，加入醋酸将pH值调至5，浸泡5h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，粉碎至800目，收集成品粉末即为西洋参破壁粉；
S3:灵芝破壁粉的制备：
(1)选取灵芝，洗净去杂质，晾干；
(2)取100g晾干的灵芝放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡5h，加入醋酸将pH值调至5，浸泡5h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，粉碎至800目，收集成品粉末即为灵芝破壁粉；
S4:制片：
(1)将S1制备的铁皮石斛提取物、S2制备的西洋参破壁粉、S3制备的灵芝破壁粉和2000g的淀粉、500g的阿拉伯胶、10g的柠檬酸、10g的硬脂酸镁充分混合均匀；
(2)再在50℃烘干，制备含水量低于5％；
(3)再进行压片、铝塑压板、包装，得到成品。
实施例二：
S1:铁皮石斛提取物的制备：
(1)将铁皮石斛除去枝叶和茎干表皮；
(2)取450g去皮的铁皮石斛茎干，切成段，将其充分压榨至渣状；
(3)用5倍重量的水进行煎煮，过滤收取滤液，再加入清水反复煎煮2次，每次煎煮1.5h；
(4)合并滤液，并在温度为70℃下进行减压浓缩，得铁皮石斛浓缩物；
(5)将铁皮石斛浓缩物在温度为75℃干燥至颗粒粉状，得铁皮石斛提取物，备用；
S2:西洋参破壁粉制备：
(1)选取西洋参，洗净去杂质，晾干；
(2)取150g晾干的西洋参放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至400目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡7.5h，加入醋酸将pH值调至5，浸泡8h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，粉碎至900目，收集成品粉末即为西洋参破壁粉；
S3:灵芝破壁粉的制备：
(1)选取灵芝，洗净去杂质，晾干；
(2)取150g晾干的灵芝放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至400目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡7.5h，加入醋酸将pH值调至小于6，浸泡8h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到900目的粉末，收集成品粉末即为灵芝破壁粉；
S4:制片：
(1)将S1制备的铁皮石斛提取物、S2制备的西洋参破壁粉、S3制备的灵芝破壁粉和2500g的蔗糖、750g的明胶、30g的抗坏血酸、30g的滑石粉充分混合均匀；
(2)再在55℃烘干，制备含水量低于5％；
(3)再进行压片、铝塑压板、包装，得到成品。
实施例三：
S1:铁皮石斛提取物的制备：
(1)将铁皮石斛除去枝叶和茎干表皮；
(2)取6000g去皮的铁皮石斛茎干，切成段，将其充分压榨至渣状；
(3)用6倍重量的水进行煎煮，过滤收取滤液，再加入清水反复煎煮3次，每次煎煮2h；
(4)合并滤液，并在温度为80℃下进行减压浓缩，得铁皮石斛浓缩物；
(5)将铁皮石斛浓缩物在温度为80℃干燥至颗粒粉状，铁皮石斛提取物，备用；
S2:西洋参破壁粉制备：
(1)选取西洋参，洗净去杂质，晾干；
(2)取2000g晾干的西洋参放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至500目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡10h，加入醋酸将pH值调至5，浸泡10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到1000目的粉末，收集成品粉末即为西洋参破壁粉；
S3:灵芝破壁粉的制备：
(1)选取灵芝，洗净去杂质，晾干；
(2)取2000g晾干的灵芝放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至500目的细粒；
(3)将细粒置于醋酸钠溶液中浸泡10h，加入醋酸将pH值调至5，浸泡10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到1000目的粉末，收集成品粉末即为灵芝破壁粉；
S4:制片：
(1)将S1制备的铁皮石斛提取物、S2制备的西洋参破壁粉、S3制备的灵芝破壁粉和30000g填充剂(5000g淀粉、5000g蔗糖、5000g乳糖、5000g葡萄糖、5000g甘露糖、5000g木糖醇)、10000g粘合剂(2000g阿拉伯胶、2000g明胶、2000g甲基纤维素、2000g羧甲基纤维素、2000g聚乙二醇)、500g的酸味剂(250g柠檬酸、250g抗坏血酸)、500g的润滑剂(250g硬脂酸镁、250g滑石粉)混合均匀；
(2)再在60℃烘干，制备含水量低于5％；
(3)再进行压片、铝塑压板、包装，得到成品。
以下举几个食用本发明含片典型实例说明效果。
例一：李某某，广西桂林市人，女，58岁。服用前：体虚无力、睡眠不好；服用本发明复方含片2个月后：睡眠好、精气神足。
例二：龚某，广西柳州人，男，49岁。服用前：皮肤黝黑，暗淡无光泽；服用本发明复方含片4个月后：皮肤变细腻，面部红润。
Claims (9)
1.一种铁皮石斛复方含片，其特征在于，该铁皮石斛复方含片各原料的重量份数如下：
铁皮石斛 30-60份
西洋参 10-20份
灵芝 10-20份
填充剂 200-300份
粘合剂 50-100份
酸味剂 1-5份
润滑剂 1-5份。
2.如权利要求1所述的铁皮石斛复方含片，其特征在于，该铁皮石斛复方含片各原料的重量份数如下：
铁皮石斛 45份
西洋参 15份
灵芝 15份
填充剂 250份
粘合剂 75份
酸味剂 3份
润滑剂 3份。
3.如权利要求1或者2所述的铁皮石斛复方含片，其特征在于，所述的填充剂为：淀粉，糊精，蔗糖，微晶纤维素，乳糖，变性淀粉，预胶化淀粉，葡萄糖，甘露糖，木糖醇，超级羧甲基淀粉钠、羧甲基淀粉钠、低取代羟丙基纤维素、交联聚乙烯吡咯烷酮、交联羧甲基纤维素钠、低取代羟丙纤维素的一种或者多种混合物。
4.如权利要求1或者2所述的铁皮石斛复方含片，其特征在于，所述的粘合剂为：阿拉伯胶、明胶、甲基纤维素、羧甲基纤维素、乙基纤维素、聚乙烯醇、聚乙二醇、聚乙烯毗咯烷酮、黄原胶的一种或者多种混合物。
5.如权利要求1或者2所述的铁皮石斛复方含片，其特征在于，所述的酸味剂为：柠檬酸或抗坏血酸的一种或者两者混合物。
6.如权利要求1或者2所述的铁皮石斛复方含片，其特征在于，所述的润滑剂为：硬脂酸镁，滑石粉的一种或者两者混合物。
7.一种如权利要求1或者2所述的铁皮石斛复方含片的制备方法，其特征在于，该制备方法包括如下步骤：
S1:铁皮石斛提取物的制备：
(1)取铁皮石斛，除去枝叶和茎干表皮；
(2)将去皮的铁皮石斛茎干切成段，再将其充分压榨至渣状；
(3)用4-6倍量水进行煎煮，过滤收取滤液，再加入清水反复煎煮2-3次，每次煎煮1-2h；
(4)合并滤液，并在温度为60-80℃下进行减压浓缩，得铁皮石斛浓缩物；
(5)将铁皮石斛浓缩物在温度为70-80℃干燥至颗粒粉状，得铁皮石斛提取物，备用；
S2:西洋参破壁粉制备：
(1)选取西洋参，洗净去杂质，晾干；
(2)将晾干的西洋参放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300-500目的细粒；
(3)将细粒置于弱碱溶液中浸泡5-10h，加入弱酸将pH值调至小于7，浸泡5-10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到800-1000目的粉末，收集成品粉末即为西洋参破壁粉；
S3:灵芝破壁粉的制备：
(1)选取灵芝，洗净去杂质，晾干；
(2)将晾干的灵芝放入打粉机进行粗粉碎，再经过超细粉碎机，粉碎至300-500目的细粒；
(3)将细粒置于稀碱溶液中浸泡5-10h，加入弱酸将pH值调至小于7，浸泡5-10h；
(4)再用纯净水洗涤，然后过滤得到细粒；
(5)将过滤得到细粒低温干燥、冷冻后，加入低温气流粉碎机，得到800-1000目的粉末，收集成品粉末即为灵芝破壁粉；
S4:制片：
(1)将S1制备的铁皮石斛提取物、S2制备的西洋参破壁粉、S3制备的灵芝破壁粉和填充剂、粘合剂、酸味剂、润滑剂按重量比充分混合均匀；
(2)再在50-60℃烘干，制备含水量低于5％；
(3)再进行压片、铝塑压板、包装，得到成品。
8.如权利要求7所述的铁皮石斛复方含片的制备方法，其特征在于，所述的S2步骤(3)中弱碱为醋酸钠溶液，弱酸为醋酸溶液。
9.如权利要求7所述的铁皮石斛复方含片的制备方法，其特征在于，所述的S3步骤(3)中，所述的弱酸为醋酸溶液，弱酸为醋酸溶液。
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| CN101152007A (zh) * | 2007-10-19 | 2008-04-02 | 金华寿仙谷药业有限公司 | 一种保健品组合物及其制备方法 |
| US20120315289A1 (en) * | 2011-06-13 | 2012-12-13 | Hsin-Sheng Tsay | Non-polysaccharide constituent of genus Dendrobium, usage for the non-polysaccharide constituent of genus Dendrobium and extracting method thereof |
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