CN107998251A - Granatum chinaroot greenbrier extracting solution and its extracting method and application - Google Patents
Granatum chinaroot greenbrier extracting solution and its extracting method and application Download PDFInfo
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Abstract
The present invention relates to granatum chinaroot greenbrier extraction process technology field, it is a kind of granatum chinaroot greenbrier extracting solution and its extracting method and application, the granatum chinaroot greenbrier extracting solution, raw material include granatum, safflower, Radix Salviae Miltiorrhizae, Poria cocos, reticulate millettia, chinaroot greenbrier, common fig leaf juice and Exocarpium Juglandis Immaturus.The extracting method of granatum chinaroot greenbrier extracting solution of the present invention can improve the recovery rate of extract, and present invention firstly discloses the granatum chinaroot greenbrier extracting solution as the application for preparing with covering and treating leucoderma double action medicine, after being treated using granatum chinaroot greenbrier extracting solution of the present invention to patients with vitiligo, the stress of patient can effectively be alleviated and improve the enthusiasm to treatment, obtain preferable partner treatment effect, significantly improve curative effect, furthermore, granatum chinaroot greenbrier extracting solution of the present invention is to skin without any irritation and damaging, without strange taste, it is a kind of safe and effective extracting solution for being suitable for longer-term and using.
Description
Technical field
The present invention relates to granatum chinaroot greenbrier extraction process technology field, is a kind of granatum chinaroot greenbrier extracting solution and its extraction side
Method, and the granatum chinaroot greenbrier extracting solution is as the application for preparing with covering and treating leucoderma double action medicine.
Background technology
At present, with the pollution of environment and the raising of human lives' pressure, patients with vitiligo is increasing, and leucoderma belongs to
Difficult and complicated cases, the cause of disease is complicated, and complete cure rate is low, and the course for the treatment of of medication is very long, especially exposure portion（On hand and face）In vain
The complete cure rate of purplish or white patches on the skin wind is low, and is easier to drug resistance, causes patient to lose the patience of long-term continued treatment.Although leucoderma is to strong
Health has no significant effect, but stress caused by it is larger, a degree of to influence normal work study and social interactions.
If carrying out the treatment of non-invasi to leucoderma using pure natural autonomic drug active ingredient, and produce at the same time over the course for the treatment of
Raw preferable covering effect, can improve the treatment confidence of patient, alleviate stress, obtain the positive partner treatment of patient, can
Improve the effect for the treatment of.
At present, using chinaroot greenbrier, safflower, reticulate millettia, the root of Dahurain angelica, smilax as the water extract of formula, it is mainly used as treatment leucoderma
Externally applied liniment, the water extract using water as extractant, heating boil one and a half hours, filter, filter residue reheat boils extraction
Filtering, merges extracting solution, and heating is concentrated to give water extract, and the medicinal extract that water extract leaves by conventional vacuum recycling design is done
After dry, solid extract is obtained, in the extraction process by water, the recovery rate of solid extract is relatively low.
The content of the invention
The present invention provides a kind of granatum chinaroot greenbrier extracting solution and its extracting method and the granatum chinaroot greenbrier extracting solution
As the application with covering and treatment leucoderma double action medicine is prepared, the deficiency of the above-mentioned prior art, its energy are overcome
Effectively solve the problems, such as that the extraction processes such as chinaroot greenbrier are relatively low there are recovery rate；Present invention firstly discloses granatum chinaroot greenbrier extraction
Liquid is as the application for preparing with covering and treating leucoderma double action medicine.
One of technical scheme is realized by following measures：A kind of granatum chinaroot greenbrier extracting solution, with
To 1000 parts of granatum chinaroot greenbrier extracting solution meter, raw materials by weight portion meter includes 250 parts to 350 parts of granatum, 28 parts of safflower
To 65 parts, 58 parts to 95 parts of Radix Salviae Miltiorrhizae, 120 parts to 258 parts of Poria cocos, 30 parts to 85 parts of reticulate millettia, 85 parts to 155 parts of chinaroot greenbrier, without flower
90 parts to 180 parts of 60 parts to 155 parts of fruit leaf and Exocarpium Juglandis Immaturus.
Here is the further optimization and/or improvements to one of foregoing invention technical solution：
Above-mentioned granatum chinaroot greenbrier extracting solution, obtains as follows：The first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower,
Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia using alcohol solution dipping 8 hours to 10 it is small when after obtain soak, ethanol solution
Usage amount, which is subject to, submerges the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia；Second step, will
Refluxing extraction obtains first time extracting solution after 60 minutes to 180 minutes under conditions of soak is 65 DEG C to 90 DEG C in temperature；The
Three steps, obtain extracting solution one and the dregs of a decoction one after first time extracting solution is filtered, the dregs of a decoction one are added the dregs of a decoction are obtained in ethanol solution
Ethanol, the ethanol solution amount added in the dregs of a decoction one, which is subject to, submerges the dregs of a decoction one, in temperature is 65 DEG C to 90 by dregs of a decoction ethanol
Refluxing extraction obtains second of extracting solution under conditions of DEG C after 60 minutes to 180 minutes, is obtained after second of extracting solution is filtered
Extracting solution two and the dregs of a decoction two；4th step, merges extracting solution one and extracting solution two obtains total extracting solution, and total extracting solution is heated and is concentrated
To total extracting liquid volume 1/5th to obtaining concentrate after half；5th step, the desired amount of Exocarpium Juglandis Immaturus are squeezed
After obtain Exocarpium Juglandis Immaturus juice, obtain granatum greenbrier after the concentrate that the 4th step obtains is uniformly mixed and is filtered with Exocarpium Juglandis Immaturus juice
Chinaroot greenbrier extracting solution.
In above-mentioned second step, the temperature of refluxing extraction is 78 DEG C, and the time of refluxing extraction is 95 minutes.
In above-mentioned 3rd step, the temperature of refluxing extraction is 78 DEG C, and the time of refluxing extraction is 95 minutes.
In the above-mentioned first step, the mass percent of ethanol solution is 30% to 75%；Or/and in the first step, will be the desired amount of
After chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia are ground into powder, then using alcohol solution dipping；
Or/and in the first step, the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia are mixed in order
After conjunction, then using alcohol solution dipping.
The two of technical scheme are realized by following measures：A kind of extraction of granatum chinaroot greenbrier extracting solution
Method, carries out as follows：The first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and chicken
Blood rattan using alcohol solution dipping 8 hours to 10 it is small when after obtain soak, the usage amount of ethanol solution is the desired amount of to submerge
Subject to chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia；Second step, by soak temperature for 65 DEG C extremely
Refluxing extraction obtains first time extracting solution under conditions of 90 DEG C after 60 minutes to 180 minutes；3rd step, by first time extracting solution mistake
Extracting solution one and the dregs of a decoction one are obtained after filter, the dregs of a decoction one are added in ethanol solution and obtain dregs of a decoction ethanol, are added in the dregs of a decoction one
Ethanol solution amount, which is subject to, submerges the dregs of a decoction one, and refluxing extraction 60 is divided under conditions of being 65 DEG C to 90 DEG C in temperature by dregs of a decoction ethanol
Clock will obtain extracting solution two and the dregs of a decoction two to second of extracting solution is obtained after 180 minutes after second of extracting solution filtering；4th
Step, merges extracting solution one and extracting solution two obtains total extracting solution, and the heating of total extracting solution is concentrated into five points of total extracting liquid volume
One of to obtaining concentrate after half；5th step, will obtain Exocarpium Juglandis Immaturus juice, by the after the squeezing of the desired amount of Exocarpium Juglandis Immaturus
The concentrate that four steps obtain obtains granatum chinaroot greenbrier extracting solution after being uniformly mixed and filter with Exocarpium Juglandis Immaturus juice.
Here is two further optimization and/or improvements to foregoing invention technical solution：
In above-mentioned second step, the temperature of refluxing extraction is 78 DEG C, and the time of refluxing extraction is 95 minutes.
In above-mentioned 3rd step, the temperature of refluxing extraction is 78 DEG C, and the time of refluxing extraction is 95 minutes.
In the above-mentioned first step, the mass percent of ethanol solution is 30% to 75%；Or/and in the first step, will be the desired amount of
After chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia are ground into powder, then using alcohol solution dipping；
Or/and in the first step, the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia are mixed in order
After conjunction, then using alcohol solution dipping.
The three of technical scheme are realized by following measures：A kind of granatum chinaroot greenbrier extracting solution is as system
It is standby that there is the application for covering and treating leucoderma double action medicine.
The extracting method of granatum chinaroot greenbrier extracting solution of the present invention can improve the recovery rate of extract, and the present invention
Making public for the first time the granatum chinaroot greenbrier extracting solution has the application for covering and treating leucoderma double action medicine as preparation,
After being treated using granatum chinaroot greenbrier extracting solution of the present invention to patients with vitiligo, it can effectively alleviate the stress of patient simultaneously
The enthusiasm to treatment is improved, preferable partner treatment effect is obtained, significantly improves curative effect, furthermore, pomegranate of the present invention
Skin chinaroot greenbrier extracting solution is a kind of to be suitable for the safety that longer-term uses and have without any irritation and damaging, no strange taste to skin
Extracting solution is imitated, and there are preferable application and development value and market prospects.
Embodiment
The present invention from following embodiments limitation, can technique according to the invention scheme and actual conditions determine specifically
Embodiment.Various chemical reagent and chemical article are previously mentioned in the present invention unless otherwise specified, are public in the prior art
Know common chemical reagent and chemical article；Percentage in the present invention is mass percent as not having specified otherwise；This hair
It is the aqueous solution that solvent is water, for example, hydrochloric acid solution is aqueous hydrochloric acid solution if the solution in bright is without specified otherwise；This
Room temperature, room temperature in invention refer generally to 15 DEG C to 25 DEG C of temperature, are commonly defined as 25 DEG C.
With reference to embodiment, the invention will be further described：
Embodiment 1：The granatum chinaroot greenbrier extracting solution, in terms of the granatum chinaroot greenbrier extracting solution for obtaining 1000 parts, raw material is by weight
Number meter includes 250 parts to 350 parts of granatum, 28 parts to 65 parts of safflower, 58 parts to 95 parts of Radix Salviae Miltiorrhizae, 120 parts to 258 parts of Poria cocos, chicken
90 parts to 180 parts of 30 parts to 85 parts of blood rattan, 85 parts to 155 parts of chinaroot greenbrier, 60 parts to 155 parts of common fig leaf juice and Exocarpium Juglandis Immaturus.
The granatum chinaroot greenbrier extracting solution obtained as the formula extraction described in the present embodiment, by increasing capacitance it is possible to increase percutaneous permeability, this
Formula is relative to the existing outer chinaroot greenbrier water extract wiped for treating leucoderma（Old preparation）For, add and Vitiligo Skin is hidden
Lid and three kinds of medicinal materials of steady color effect（Granatum, common fig leaf juice and Exocarpium Juglandis Immaturus）, make granatum chinaroot greenbrier extracting solution coloring effect
Fruit is good, free from extraneous odour, it is not easy to decolourize, it is easy to use, the covering for the leucoderma being particularly suitable in the exposure portions such as hand and face and
Treatment.
Granatum chinaroot greenbrier extracting solution described in the present embodiment belongs to pure natural plant medicament extracting solution, without any artificial synthesized
Chemical composition.
Embodiment 2：The granatum chinaroot greenbrier extracting solution, in terms of the granatum chinaroot greenbrier extracting solution for obtaining 1000 parts, raw material is by weight
Measuring number meter includes 250 parts or 350 parts of granatum, 28 parts or 65 parts of safflower, 58 parts or 95 parts of Radix Salviae Miltiorrhizae, 120 parts of Poria cocos or 258
90 parts or 180 parts of part, 30 parts or 85 parts of reticulate millettia, 85 parts or 155 parts of chinaroot greenbrier, 60 parts or 155 parts of common fig leaf juice and Exocarpium Juglandis Immaturus.
Embodiment 3：The granatum chinaroot greenbrier extracting solution, in terms of the granatum chinaroot greenbrier extracting solution for obtaining 1000 parts, raw material is by weight
Measure number meter include 250 parts of granatum, 65 parts of safflower, 58 parts of Radix Salviae Miltiorrhizae, 120 parts of Poria cocos, 85 parts of reticulate millettia, 85 parts of chinaroot greenbrier, without flower
180 parts of 155 parts of fruit leaf and Exocarpium Juglandis Immaturus.
Embodiment 4：The granatum chinaroot greenbrier extracting solution, in terms of the granatum chinaroot greenbrier extracting solution for obtaining 1000 parts, raw material is by weight
Measure number meter include 350 parts of granatum, 28 parts of safflower, 95 parts of Radix Salviae Miltiorrhizae, 258 parts of Poria cocos, 30 parts of reticulate millettia, 155 parts of chinaroot greenbrier, without flower
90 parts of 60 parts of fruit leaf and Exocarpium Juglandis Immaturus.
Embodiment 5:Granatum chinaroot greenbrier extracting solution is obtained by following extracting methods：The first step, by the desired amount of chinaroot greenbrier, without flower
Fruit leaf, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia using alcohol solution dipping 8 hours to 10 it is small when after obtain soak,
The usage amount of ethanol solution using submerge the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia as
It is accurate；Second step, refluxing extraction obtains first after 60 minutes to 180 minutes under conditions of being 65 DEG C to 90 DEG C in temperature by soak
Secondary extracting solution；3rd step, obtains extracting solution one and the dregs of a decoction one after first time extracting solution is filtered, the dregs of a decoction one is added ethanol solution
In obtain dregs of a decoction ethanol, the ethanol solution amount added in the dregs of a decoction one, which is subject to, submerges the dregs of a decoction one, by dregs of a decoction ethanol in temperature
Second of extracting solution is obtained after 60 minutes to 180 minutes for refluxing extraction under conditions of 65 DEG C to 90 DEG C, by second of extracting solution
Extracting solution two and the dregs of a decoction two are obtained after filtering；4th step, merges extracting solution one and extracting solution two obtains total extracting solution, will always extract
Liquid heating is concentrated into 1/5th of total extracting liquid volume to obtaining concentrate after half；5th step, by the desired amount of green grass or young crops
Exocarpium Juglandis Immaturus juice is obtained after Cortex walnut squeezing, after the concentrate that the 4th step obtains is uniformly mixed and is filtered with Exocarpium Juglandis Immaturus juice
To granatum chinaroot greenbrier extracting solution.
When extracting method according to the present embodiment is extracted, using ethanol solution as extractant, relative to existing
There is extraction process by water, it is possible to increase the recovery rate of solid extract, the fat-soluble and skin for increasing extracting solution ooze performance.
After extract dry of the granatum chinaroot greenbrier extracting solution that the present invention obtains through routinely solvent is recovered under reduced pressure and leaves, obtain
Obtain solid extract.
Compared to existing extraction process by water, the extracting method described in the present embodiment improves 20% to the recovery rate of solid extract
To 25%.
And existing extraction process by water refluxing extraction temperature is reaches 100 DEG C, and the extracting method described in the present embodiment flows back
Extracting temperature is less than 90 DEG C, and the extracting method described in the present embodiment not only reduces extraction energy consumption, but also can reduce extract
The extent of the destruction of the middle thermo-responsive active ingredient of heating.
Embodiment 6：Granatum chinaroot greenbrier extracting solution is obtained by following extracting methods:The first step, by the desired amount of chinaroot greenbrier, without flower
Soak is obtained after when fruit leaf, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia use alcohol solution dipping 8 small or when 10 is small,
The usage amount of ethanol solution using submerge the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia as
It is accurate；Second step, refluxing extraction obtains first after 60 minutes or 180 minutes under conditions of being 65 DEG C or 90 DEG C in temperature by soak
Secondary extracting solution；3rd step, obtains extracting solution one and the dregs of a decoction one after first time extracting solution is filtered, the dregs of a decoction one is added ethanol solution
In obtain dregs of a decoction ethanol, the ethanol solution amount added in the dregs of a decoction one, which is subject to, submerges the dregs of a decoction one, by dregs of a decoction ethanol in temperature
Second of extracting solution is obtained after 60 minutes or 180 minutes for refluxing extraction under conditions of 65 DEG C or 90 DEG C, by second of extracting solution
Extracting solution two and the dregs of a decoction two are obtained after filtering；4th step, merges extracting solution one and extracting solution two obtains total extracting solution, will always extract
Liquid heating obtains concentrate after being concentrated into 1/5th or half of total extracting liquid volume；5th step, by the desired amount of green grass or young crops
Exocarpium Juglandis Immaturus juice is obtained after Cortex walnut squeezing, after the concentrate that the 4th step obtains is uniformly mixed and is filtered with Exocarpium Juglandis Immaturus juice
To granatum chinaroot greenbrier extracting solution.
Embodiment 7：Granatum chinaroot greenbrier extracting solution is obtained by following extracting methods:The first step, by the desired amount of chinaroot greenbrier, without flower
Soak, ethanol solution are obtained after when fruit leaf, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia use alcohol solution dipping 8 small
Usage amount be subject to and submerge the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia；Second step,
By soak, refluxing extraction obtains first time extracting solution after sixty minutes under the conditions of at a temperature of 90 °C；3rd step, will be for the first time
Extracting solution one and the dregs of a decoction one are obtained after extracting solution filtering, the dregs of a decoction one are added in ethanol solution and obtain dregs of a decoction ethanol, the dregs of a decoction one
The ethanol solution amount of middle addition, which is subject to, submerges the dregs of a decoction one, refluxing extraction under conditions of being 65 DEG C in temperature by dregs of a decoction ethanol
Second of extracting solution is obtained after 180 minutes, extracting solution two and the dregs of a decoction two are obtained after second of extracting solution is filtered；4th step, is closed
And extracting solution one and extracting solution two obtain total extracting solution, after the heating of total extracting solution is concentrated into the half of total extracting liquid volume
Obtain concentrate；5th step, obtains Exocarpium Juglandis Immaturus juice, the concentrate that the 4th step is obtained after the desired amount of Exocarpium Juglandis Immaturus are squeezed
Granatum chinaroot greenbrier extracting solution is obtained after being uniformly mixed and filter with Exocarpium Juglandis Immaturus juice.In product（Granatum chinaroot greenbrier extracting solution）Amount
At 1000 grams, 250 grams of granatum, 28 grams of safflower, 58 grams of Radix Salviae Miltiorrhizae, 258 grams of Poria cocos, 85 grams of reticulate millettia, 85 grams of chinaroot greenbrier, fig are taken
90 grams of 155 grams of leaf and Exocarpium Juglandis Immaturus.
After the extract dry that the granatum chinaroot greenbrier extracting solution that the present embodiment obtains is recovered under reduced pressure solvent and is left through routine,
Obtain 19.5 grams of solid extracts；And the Aqueous extracts that existing process obtains are through the conventional extract dry that solvent is recovered under reduced pressure and leaves
Afterwards, 15.4 grams of solid extracts are obtained,
The recovery rate of extracting method i.e. described in the present embodiment improves 21%,（19.5-15.4）x100% /19.5 =21%.
Embodiment 8：Granatum chinaroot greenbrier extracting solution is obtained by following extracting methods：The first step, by the desired amount of chinaroot greenbrier, without flower
Soak, ethanol solution are obtained after when fruit leaf, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia use alcohol solution dipping 10 small
Usage amount be subject to and submerge the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia；Second step,
Refluxing extraction obtains first time extracting solution after 180 minutes under conditions of being 65 DEG C in temperature by soak；3rd step, will be for the first time
Extracting solution one and the dregs of a decoction one are obtained after extracting solution filtering, the dregs of a decoction one are added in ethanol solution and obtain dregs of a decoction ethanol, the dregs of a decoction one
The ethanol solution amount of middle addition, which is subject to, submerges the dregs of a decoction one, by dregs of a decoction ethanol under the conditions of at a temperature of 90 °C refluxing extraction 60
Second of extracting solution is obtained after minute, extracting solution two and the dregs of a decoction two are obtained after second of extracting solution is filtered；4th step, merging carry
Take liquid one and extracting solution two to obtain total extracting solution, the heating of total extracting solution is concentrated into after 1/5th of total extracting liquid volume and is obtained
Concentrate；5th step, Exocarpium Juglandis Immaturus juice is obtained after the desired amount of Exocarpium Juglandis Immaturus are squeezed, the concentrate that the 4th step is obtained and green grass or young crops
Cortex walnut juice is uniformly mixed and granatum chinaroot greenbrier extracting solution is obtained after filtering.In product（Granatum chinaroot greenbrier extracting solution）1000 grams of amount
When, take 350 grams of granatum, 65 grams of safflower, 95 grams of Radix Salviae Miltiorrhizae, 120 grams of Poria cocos, 30 grams of reticulate millettia, 155 grams of chinaroot greenbrier, common fig leaf juice 60
Gram and 180 grams of Exocarpium Juglandis Immaturus.
After the extract dry that the granatum chinaroot greenbrier extracting solution that the present embodiment obtains is recovered under reduced pressure solvent and is left through routine,
Obtain 19.25 grams of solid extracts；The recovery rate of extracting method i.e. described in the present embodiment improves 20%,（19.25-15.4）
x100% /19.25 =20%。
Embodiment 9：Optimization as embodiment 5 to embodiment 7, in second step and the 3rd step, the temperature of refluxing extraction is equal
For 78 DEG C, the time of refluxing extraction is 95 minutes.
Embodiment 10：The granatum chinaroot greenbrier extracting solution, in second step and the 3rd step, the temperature of refluxing extraction is 78 DEG C,
The time of refluxing extraction is 95 minutes, other same embodiments 8.
After the extract dry that the granatum chinaroot greenbrier extracting solution that the present embodiment obtains is recovered under reduced pressure solvent and is left through routine,
Obtain 19.25 grams of solid extracts；The recovery rate of extracting method i.e. described in the present embodiment improves 25%,（20.53-15.4）
x100% /20.53=25%。
Embodiment 11：Optimization as embodiment 5 to embodiment 8, in the first step, the mass percent of ethanol solution is
30% to 75%；Or/and in the first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia
After being ground into powder, then using alcohol solution dipping；Or/and in the first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower,
After Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia mix in order, then using alcohol solution dipping.
Embodiment 12：Granatum chinaroot greenbrier extracting solution described in above-described embodiment is as preparation with covering and treatment leucoderma
The application of double action medicine.
It will be wiped outside granatum chinaroot greenbrier extracting solution described in above-described embodiment in Vitiligo Skin position, about after five minutes, skin
Color is close to normal skin tone, better if affected part sunlight irradiates 5 to 10 minutes.
Treatment and covering effect of the granatum chinaroot greenbrier extracting solution to leucoderma described in above-described embodiment is through 24 months
It is proved in clinical practice and confirms, by Kaxgar Prefecture Uygur medicine hospital dermatology department director A Xier Jiang doctor（National leucoderma
Wind think tank expert）Using confirmation, take pill 95 active stage leucoderma for the treatment of orally with compatibility is wiped outside this extracting solution, treat within 2 months
Total effective rate up to 65% to 65.3%, take pill treatment total effective rate orally than old preparation compatibility（39.6% to 40%）Have and substantially carry
It is high（The total effective rate treated with new and old formulation method has significant significant difference, p ＜ 0.01）.
Granatum chinaroot greenbrier extracting solution described in above-described embodiment, has preferably to therapy of vitiligo and colours dual effect
Fruit, effectively alleviates the stress of patient and improves the enthusiasm to treatment, obtain preferable partner treatment effect, significantly improve
Curative effect, is a kind of safe and effective extraction for being suitable for longer-term and using to skin without any irritation and damaging, no strange taste
Liquid, and there are preferable application and development value and market prospects.
In conclusion the extracting method of granatum chinaroot greenbrier extracting solution of the present invention can improve the recovery rate of extract,
And present invention firstly discloses the granatum chinaroot greenbrier extracting solution as preparation with covering and treatment leucoderma double action
The application of medicine, after being treated using granatum chinaroot greenbrier extracting solution of the present invention to patients with vitiligo, can effectively alleviate patient
Stress and improve to the enthusiasm for the treatment of, obtain preferable partner treatment effect, significantly improve curative effect, furthermore, this
The granatum chinaroot greenbrier extracting solution is invented to skin without any irritation and damaging, no strange taste, is that one kind is suitable for longer-term
The safe and effective extracting solution used, and there are preferable application and development value and market prospects.
Above technical characteristic constitutes the embodiment of the present invention, it, can basis with stronger adaptability and implementation result
It is actually needed and increases and decreases non-essential technical characteristic, meets the needs of different situations.
Claims (10)
1. a kind of granatum chinaroot greenbrier extracting solution, it is characterised in that in terms of the granatum chinaroot greenbrier extracting solution for obtaining 1000 parts, raw material is pressed
Parts by weight meter includes 250 parts to 350 parts of granatum, 28 parts to 65 parts of safflower, 58 parts to 95 parts of Radix Salviae Miltiorrhizae, 120 parts to 258 of Poria cocos
90 parts to 180 parts of part, 30 parts to 85 parts of reticulate millettia, 85 parts to 155 parts of chinaroot greenbrier, 60 parts to 155 parts of common fig leaf juice and Exocarpium Juglandis Immaturus.
2. granatum chinaroot greenbrier extracting solution according to claim 1, it is characterised in that obtain as follows：The first step, will
The desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia use alcohol solution dipping 8 hours to 10
Obtain soak after hour, the usage amount of ethanol solution with submerge the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae,
Subject to granatum and reticulate millettia；Second step, refluxing extraction 60 minutes is extremely under conditions of being 65 DEG C to 90 DEG C in temperature by soak
First time extracting solution is obtained after 180 minutes；3rd step, extracting solution one and the dregs of a decoction one are obtained after first time extracting solution is filtered, will
The dregs of a decoction one add in ethanol solution and obtain dregs of a decoction ethanol, and the ethanol solution amount added in the dregs of a decoction one, which is subject to, submerges the dregs of a decoction one,
Refluxing extraction obtains second of extraction after 60 minutes to 180 minutes under conditions of being 65 DEG C to 90 DEG C in temperature by dregs of a decoction ethanol
Liquid, extracting solution two and the dregs of a decoction two are obtained after second of extracting solution is filtered；4th step, merges extracting solution one and extracting solution two obtains
Total extracting solution, 1/5th of total extracting liquid volume are concentrated into obtaining concentrate after half by the heating of total extracting solution；The
Five steps, Exocarpium Juglandis Immaturus juice is obtained after the desired amount of Exocarpium Juglandis Immaturus are squeezed, the concentrate that the 4th step is obtained and Exocarpium Juglandis Immaturus juice
It is uniformly mixed and granatum chinaroot greenbrier extracting solution is obtained after filtering.
3. granatum chinaroot greenbrier extracting solution according to claim 2, it is characterised in that in second step, the temperature of refluxing extraction is
78 DEG C, the time of refluxing extraction is 95 minutes.
4. the granatum chinaroot greenbrier extracting solution according to Claims 2 or 3, it is characterised in that in the 3rd step, the temperature of refluxing extraction
Spend for 78 DEG C, the time of refluxing extraction is 95 minutes.
5. the granatum chinaroot greenbrier extracting solution according to Claims 2 or 3 or 4, it is characterised in that in the first step, ethanol solution
Mass percent is 30% to 75%；Or/and in the first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, stone
After pomegranate skin and reticulate millettia are ground into powder, then using alcohol solution dipping；Or/and in the first step, by the desired amount of chinaroot greenbrier, nothing
After flowers and fruits leaf, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia mix in order, then using alcohol solution dipping.
6. a kind of extracting method of granatum chinaroot greenbrier extracting solution according to claim 1, it is characterised in that as follows
Carry out：The first step, ethanol solution is used by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia
Immersion 8 hours to 10 it is small when after obtain soak, the usage amount of ethanol solution is to submerge the desired amount of chinaroot greenbrier, common fig leaf juice, red
Subject to flower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia；Second step, flows back under conditions of being 65 DEG C to 90 DEG C in temperature by soak
Extraction obtains first time extracting solution after 60 minutes to 180 minutes；3rd step, extracting solution one is obtained after first time extracting solution is filtered
With the dregs of a decoction one, the dregs of a decoction one are added in ethanol solution and obtain dregs of a decoction ethanol, the ethanol solution amount added in the dregs of a decoction one is to submerge
Subject to the dregs of a decoction one, refluxing extraction obtains after 60 minutes to 180 minutes under conditions of being 65 DEG C to 90 DEG C in temperature by dregs of a decoction ethanol
To second of extracting solution, extracting solution two and the dregs of a decoction two are obtained after second of extracting solution is filtered；4th step, merges one He of extracting solution
Extracting solution two obtains total extracting solution, and the heating of total extracting solution is concentrated into 1/5th of total extracting liquid volume to after half
To concentrate；5th step, will the desired amount of Exocarpium Juglandis Immaturus squeezing after obtain Exocarpium Juglandis Immaturus juice, the concentrate that the 4th step is obtained with
Exocarpium Juglandis Immaturus juice is uniformly mixed and granatum chinaroot greenbrier extracting solution is obtained after filtering.
7. the extracting method of granatum chinaroot greenbrier extracting solution according to claim 6, it is characterised in that in second step, reflux carries
The temperature taken is 78 DEG C, and the time of refluxing extraction is 95 minutes.
8. the extracting method of the granatum chinaroot greenbrier extracting solution according to claim 6 or 7, it is characterised in that in the 3rd step, return
The temperature of stream extraction is 78 DEG C, and the time of refluxing extraction is 95 minutes.
9. the extracting method of the granatum chinaroot greenbrier extracting solution according to claim 6 or 7 or 8, it is characterised in that in the first step,
The mass percent of ethanol solution is 30% to 75%；Or/and in the first step, by the desired amount of chinaroot greenbrier, common fig leaf juice, safflower, Fu
After Siberian cocklebur, Radix Salviae Miltiorrhizae, granatum and reticulate millettia are ground into powder, then using alcohol solution dipping；Or/and in the first step, by aequum
Chinaroot greenbrier, common fig leaf juice, safflower, Poria cocos, Radix Salviae Miltiorrhizae, granatum and reticulate millettia mix in order after, then using alcohol solution dipping.
10. a kind of granatum chinaroot greenbrier extracting solution according to claim 1 or 2 or 3 or 4 or 5 as prepare have cover and
Treat the application of leucoderma double action medicine.
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| CN101496844A (en) * | 2009-03-19 | 2009-08-05 | 董娜 | External preparation for treating leukoderma and method for preparing and using the same |
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