CN107998251B

CN107998251B - Pomegranate peel chinaroot greenbrier extracting solution and extracting method and application thereof

Info

Publication number: CN107998251B
Application number: CN201711230949.0A
Authority: CN
Inventors: 木合布力·阿布力孜; 马尔霍夫·木合布力; 赵超然
Original assignee: Xinjiang Falading Biotechnology Co ltd; Xinjiang Medical University
Current assignee: Xinjiang Falading Biotechnology Co ltd; Xinjiang Medical University
Priority date: 2017-11-29
Filing date: 2017-11-29
Publication date: 2021-07-02
Anticipated expiration: 2037-11-29
Also published as: CN107998251A

Abstract

The invention relates to the technical field of pomegranate peel smilax china extraction processes, in particular to a pomegranate peel smilax china extract and an extraction method and application thereof. The extraction method of the pomegranate bark smilax china extract can improve the extraction rate of the extract, and the invention discloses the application of the pomegranate bark smilax china extract in preparing the medicine with double functions of covering and treating leucoderma for the first time.

Description

Pomegranate peel chinaroot greenbrier extracting solution and extracting method and application thereof

Technical Field

The invention relates to the technical field of pomegranate bark and smilax china extraction processes, in particular to a pomegranate bark and smilax china extract and an extraction method thereof, and application of the pomegranate bark and smilax china extract in preparing a medicine with double effects of covering and treating leucoderma.

Background

At present, along with the environmental pollution and the improvement of the living pressure of human beings, the number of patients suffering from leucoderma is increasing, the leucoderma belongs to difficult miscellaneous diseases, the etiology is complex, the complete cure rate is low, the treatment course is very long, particularly, the complete cure rate of the leucoderma at exposed parts (such as hands and faces) is low, the medicine resistance is easy, and the patients lose the patience of long-term continuous treatment. Although leucoderma has no obvious influence on health, the mental stress brought by the leucoderma is large, and normal work, study and social communication are influenced to a certain extent. If the pure natural botanical drug active ingredients are used for carrying out non-destructive treatment on the vitiligo and simultaneously generating better covering effect in the treatment process, the treatment confidence of the patient can be improved, the mental pressure can be relieved, the active cooperation treatment of the patient can be obtained, and the treatment effect can be improved.

At present, an aqueous extract prepared from chinaroot greenbrier rhizome, safflower, suberect spatholobus stem, dahurian angelica root and glabrous greenbrier rhizome is mainly used as an external liniment for treating leucoderma, the aqueous extract takes water as an extracting agent, the aqueous extract is heated and boiled for one half hour, filtered, filter residue is heated and boiled again for extraction and filtration, extracting solutions are combined and heated and concentrated to obtain an aqueous extract, the aqueous extract is subjected to conventional pressure reduction and solvent recovery to obtain an extract, and the extract is dried to obtain a solid extract.

Disclosure of Invention

The invention provides a pomegranate bark and smilax china extract, an extraction method thereof and application of the pomegranate bark and smilax china extract in preparing a medicine with double effects of covering and treating leucoderma, overcomes the defects of the prior art, and can effectively solve the problem of low extraction rate of extraction processes of smilax china and the like; the invention discloses the application of the pomegranate peel smilax china extract in preparing a medicament with double effects of covering and treating leucoderma for the first time.

One of the technical schemes of the invention is realized by the following measures: the pomegranate peel and smilax china extract is prepared from the following raw materials, by weight, 250-350 parts of pomegranate peel, 28-65 parts of safflower, 58-95 parts of salvia miltiorrhiza, 120-258 parts of poria cocos, 30-85 parts of caulis spatholobi, 85-155 parts of smilax china, 60-155 parts of fig leaves and 90-180 parts of green walnut peel, wherein the raw materials are calculated according to 1000 parts of the pomegranate peel and smilax china extract.

The following is a further optimization or/and improvement of one of the above-mentioned technical solutions of the invention:

the pomegranate peel smilax china extract is obtained by the following method: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts by adopting an ethanol solution for 8 to 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts; secondly, refluxing and extracting the soak solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth to one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

In the second step, the temperature of the reflux extraction was 78 ℃ and the time of the reflux extraction was 95 minutes.

In the third step, the temperature of the reflux extraction was 78 ℃ and the time of the reflux extraction was 95 minutes.

In the first step, the mass percent of the ethanol solution is 30-75%; or/and in the first step, the required amount of smilax china, fig leaves, safflower, tuckahoe, salvia miltiorrhiza, pomegranate bark and suberect spatholobus stem are crushed into powder and then are soaked by ethanol solution; or/and in the first step, mixing the required amount of chinaroot greenbrier, fig leaves, safflower, tuckahoe, salvia miltiorrhiza, pomegranate bark and suberect spatholobus stem in sequence, and then soaking by adopting an ethanol solution.

The second technical scheme of the invention is realized by the following measures: a method for extracting a pomegranate peel smilax china extract comprises the following steps: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts by adopting an ethanol solution for 8 to 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts; secondly, refluxing and extracting the soak solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth to one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

The following is further optimization or/and improvement of the second technical scheme of the invention:

The third technical scheme of the invention is realized by the following measures: an application of the extractive solution of Smilax granatum in preparing the medicines for covering and treating vitiligo is disclosed.

The extraction method of the pomegranate bark smilax china extract can improve the extraction rate of the extract, and the invention discloses the application of the pomegranate bark smilax china extract in preparing the medicine with double functions of covering and treating leucoderma for the first time.

Detailed Description

The present invention is not limited by the following examples, and specific embodiments may be determined according to the technical solutions and practical situations of the present invention. The various chemical reagents and chemical articles mentioned in the invention are all the chemical reagents and chemical articles which are well known and commonly used in the prior art, unless otherwise specified; the percentages in the invention are mass percentages unless otherwise specified; the solution in the present invention is an aqueous solution in which the solvent is water, for example, a hydrochloric acid solution is an aqueous hydrochloric acid solution, unless otherwise specified; the normal temperature and room temperature in the present invention generally mean a temperature of 15 ℃ to 25 ℃, and are generally defined as 25 ℃.

The invention is further described below with reference to the following examples:

example 1: the pomegranate peel-smilax china extract is prepared from the following raw materials, by weight, 250-350 parts of pomegranate peel, 28-65 parts of safflower, 58-95 parts of salvia miltiorrhiza, 120-258 parts of poria cocos, 30-85 parts of caulis spatholobi, 85-155 parts of smilax china, 60-155 parts of fig leaves and 90-180 parts of green walnut peel, wherein the raw materials are calculated according to 1000 parts of the pomegranate peel-smilax china extract.

Compared with the existing smilax aqueous extract (old preparation) externally wiped for treating leucoderma, the formula increases three medicinal materials (pomegranate bark, fig leaves and green walnut skin) with functions of covering and stabilizing the skin of leucoderma, so that the pomegranate bark smilax extracting solution has a good coloring effect, is free from peculiar smell, is not easy to decolor, is convenient to use, and is particularly suitable for covering and treating the leucoderma on exposed parts such as hands, faces and the like.

The pomegranate bark and smilax china extract in the embodiment belongs to a pure natural botanical extract and does not contain any artificially synthesized chemical components.

Example 2: the pomegranate peel-smilax china extract comprises, by weight, 250 parts or 350 parts of pomegranate peel, 28 parts or 65 parts of safflower, 58 parts or 95 parts of salvia miltiorrhiza, 120 parts or 258 parts of poria cocos, 30 parts or 85 parts of caulis spatholobi, 85 parts or 155 parts of smilax china, 60 parts or 155 parts of fig leaves and 90 parts or 180 parts of green walnut peel, wherein the 1000 parts of the pomegranate peel-smilax china extract is obtained.

Example 3: the pomegranate peel and smilax china extract comprises the raw materials of 250 parts of pomegranate peel, 65 parts of safflower, 58 parts of salvia miltiorrhiza, 120 parts of tuckahoe, 85 parts of caulis spatholobi, 85 parts of smilax china, 155 parts of fig leaves and 180 parts of green walnut peel in parts by weight based on 1000 parts of the pomegranate peel and smilax china extract.

Example 4: the pomegranate peel-smilax china extract comprises, by weight, 350 parts of pomegranate peel, 28 parts of safflower, 95 parts of salvia miltiorrhiza, 258 parts of poria cocos, 30 parts of caulis spatholobi, 155 parts of smilax china, 60 parts of fig leaves and 90 parts of green walnut peel, wherein the 1000 parts of the pomegranate peel-smilax china extract is obtained.

Example 5 pomegranate rind smilax china extract was obtained by the following extraction method: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts by adopting an ethanol solution for 8 to 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts; secondly, refluxing and extracting the soak solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth to one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

When the extraction method is used for extraction, the ethanol solution is used as an extracting agent, so that the extraction rate of the solid extract can be improved, and the fat solubility and skin permeability of the extracting solution can be improved compared with the existing water extraction process.

The solvent is recovered from the pomegranate peel and chinaroot greenbrier extracting solution through conventional decompression, and the remained extract is dried to obtain the solid extract.

Compared with the existing water extraction process, the extraction method disclosed by the embodiment has the advantage that the extraction rate of the solid extract is improved by 20-25%.

In addition, the reflux extraction temperature of the existing water extraction process reaches 100 ℃, while the reflux extraction temperature of the extraction method of the embodiment is below 90 ℃, the extraction method of the embodiment not only reduces the extraction energy consumption, but also can reduce the damage degree of the heating heat-sensitive active ingredients in the extract.

Example 6: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the tuckahoe, the salvia miltiorrhiza, the pomegranate bark and the suberect spatholobus stem with required amount by adopting an ethanol solution for 8 hours or 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the tuckahoe, the salvia miltiorrhiza, the pomegranate bark and the suberect spatholobus stem with required amount; secondly, refluxing and extracting the soak solution at 65 ℃ or 90 ℃ for 60 minutes or 180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65 ℃ or 90 ℃ for 60 minutes or 180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth or one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

Example 7: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the tuckahoe, the salvia miltiorrhiza, the pomegranate peel and the suberect spatholobus stem with required amount by adopting ethanol solution for 8 hours to obtain soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the tuckahoe, the salvia miltiorrhiza, the pomegranate peel and the suberect spatholobus stem with required amount; secondly, refluxing and extracting the soak solution at the temperature of 90 ℃ for 60 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution for 180 minutes at the temperature of 65 ℃ to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; fourthly, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract. When the amount of the product (pomegranate bark and smilax china extract) is 1000 g, 250 g of pomegranate bark, 28 g of safflower, 58 g of salvia miltiorrhiza, 258 g of tuckahoe, 85 g of suberect spatholobus stem, 85 g of smilax china, 155 g of fig leaves and 90 g of green walnut bark are taken.

The solvent of the pomegranate peel smilax china extract obtained in the embodiment is recovered through conventional decompression, and the remained extract is dried to obtain 19.5 g of solid extract; while the water extract obtained by the prior art is dried after the conventional decompression solvent recovery and the remained extractum to obtain 15.4 g of solid extract,

namely, the extraction rate of the extraction method described in this example is improved by 21%, (19.5-15.4) x 100%/19.5 = 21%.

Example 8: the pomegranate peel chinaroot greenbrier extracting solution is obtained by the following extracting method: firstly, soaking chinaroot greenbrier, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and caulis spatholobi in required amount for 10 hours by adopting an ethanol solution to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the salvia miltiorrhiza, the pomegranate bark and the caulis spatholobi in required amount; secondly, refluxing and extracting the soak solution at the temperature of 65 ℃ for 180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 90 ℃ for 60 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to be one fifth of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract. When the amount of the product (pomegranate bark and smilax china extract) is 1000 g, 350 g of pomegranate bark, 65 g of safflower, 95 g of salvia miltiorrhiza, 120 g of tuckahoe, 30 g of caulis spatholobi, 155 g of smilax china, 60 g of fig leaves and 180 g of green walnut skin are taken.

The solvent of the pomegranate peel smilax china extract obtained in the embodiment is recovered through conventional decompression, and the remained extract is dried to obtain 19.25 g of solid extract; that is, the extraction rate of the extraction method described in this example is improved by 20%, (19.25-15.4) x 100%/19.25 = 20%.

Example 9: as optimization of examples 5 to 7, in the second and third steps, the temperature of the reflux extraction was 78 ℃ and the time of the reflux extraction was 95 minutes.

Example 10: in the second and third steps, the temperature of reflux extraction is 78 ℃, the time of reflux extraction is 95 minutes, and the rest is the same as example 8.

The solvent of the pomegranate peel smilax china extract obtained in the embodiment is recovered through conventional decompression, and the remained extract is dried to obtain 19.25 g of solid extract; namely, the extraction rate of the extraction method described in this example is improved by 25%, (20.53-15.4) x 100%/20.53 = 25%.

Example 11: as optimization of the embodiment 5 to the embodiment 8, in the first step, the mass percent of the ethanol solution is 30 to 75 percent; or/and in the first step, the required amount of smilax china, fig leaves, safflower, tuckahoe, salvia miltiorrhiza, pomegranate bark and suberect spatholobus stem are crushed into powder and then are soaked by ethanol solution; or/and in the first step, mixing the required amount of chinaroot greenbrier, fig leaves, safflower, tuckahoe, salvia miltiorrhiza, pomegranate bark and suberect spatholobus stem in sequence, and then soaking by adopting an ethanol solution.

Example 12: the pomegranate bark and smilax china extract in the embodiment is applied to preparing a medicine with double effects of covering and treating leucoderma.

The pomegranate bark and smilax china extracting solution in the embodiment is externally applied to the skin part of the leucoderma, the skin color is close to the normal skin color after about 5 minutes, and the effect is better if the affected part is irradiated by sunlight for 5 to 10 minutes.

The treatment and covering efficacy of the pomegranate bark smilax china extract on the vitiligo is proved and confirmed in clinical application for 24 months, and is proved by application of doctors (national vitiligo Chinesian experts) in Uygur medical hospitals in karst regions, the total effective rate of the extract in 2-month treatment is 65-65.3 percent when the extract is externally applied and matched with oral pills for treating the vitiligo in 95 activity periods, and the total effective rate (39.6-40 percent) is obviously improved compared with the total effective rate (p is less than 0.01) of the extract in new and old preparation methods when the extract is used for treating the vitiligo in 2-month treatment.

The pomegranate bark and smilax china extract in the embodiment has good double effects of treating and coloring leucoderma, effectively relieves the mental pressure of patients, improves the enthusiasm of treatment, obtains good cooperative treatment effect, obviously improves the curative effect, has no irritation and damage to the skin and no strange taste, is a safe and effective extract suitable for being used for a long time, and has good application and development values and market prospects.

In conclusion, the extraction method of the pomegranate bark smilax china extract can improve the extraction rate of the extract, and the invention discloses the application of the pomegranate bark smilax china extract in preparing the medicine with double functions of covering and treating leucoderma for the first time.

The technical characteristics form an embodiment of the invention, which has strong adaptability and implementation effect, and unnecessary technical characteristics can be increased or decreased according to actual needs to meet the requirements of different situations.

Claims

1. The pomegranate peel and smilax china extract is characterized by comprising the raw materials of 250 to 350 parts of pomegranate peel, 28 to 65 parts of safflower, 58 to 95 parts of salvia miltiorrhiza, 120 to 258 parts of poria cocos, 30 to 85 parts of suberect spatholobus stem, 85 to 155 parts of smilax china, 60 to 155 parts of fig leaves and 90 to 180 parts of green walnut peel by weight parts based on 1000 parts of the pomegranate peel and smilax china extract.

2. The pomegranate bark smilax china extract according to claim 1, which is obtained by the following method: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts by adopting an ethanol solution for 8 to 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts; secondly, refluxing and extracting the soak solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth to one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

3. The extractive solution of Smilax granatum L.in claim 2, wherein the temperature of reflux extraction in the second step is 78 deg.C and the time of reflux extraction is 95 min.

4. The extractive solution of Smilax granatum L.of claim 2 or 3, wherein the reflux extraction temperature in the third step is 78 deg.C and the reflux extraction time is 95 min.

5. The sarsaparilla extract as claimed in claim 2 or 3, wherein the ethanol solution is 30-75% by weight in the first step.

6. The extractive solution of pomegranate bark smilax china according to claim 4, wherein the ethanol solution is 30 to 75% by mass in the first step.

7. The extractive solution of Smilax granatum L. as claimed in claim 1, 2, 3 or 6, wherein in the first step, desired amounts of Smilax china L, folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi are pulverized into powder, and then soaked in ethanol solution.

8. The extractive solution of Smilax granatum L.in claim 4, wherein in the first step, the desired amount of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi is pulverized into powder, and then soaked in ethanol solution.

9. The extractive solution of Smilax granatum L.in claim 5, wherein in the first step, the desired amount of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi is pulverized into powder, and then soaked in ethanol solution.

10. The extractive solution of Smilax granatum L.in claim 1, 2, 3 or 6, wherein in the first step, desired amounts of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi are mixed in order, and then soaked in ethanol solution.

11. The extractive solution of Smilax granatum L.in claim 4, wherein in the first step, the desired amount of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi is mixed sequentially, and then soaked in ethanol solution.

12. The extractive solution of Smilax granatum L.in claim 5, wherein in the first step, the desired amounts of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi are mixed in order, and then soaked in ethanol solution.

13. The extraction method of the pomegranate bark smilax china extract according to claim 1, which is characterized by comprising the following steps: firstly, soaking the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts by adopting an ethanol solution for 8 to 10 hours to obtain a soaking solution, wherein the usage amount of the ethanol solution is based on the immersion of the chinaroot greenbrier, the fig leaves, the safflower, the poria cocos, the red sage root, the pomegranate bark and the suberect spatholobus stem with required amounts; secondly, refluxing and extracting the soak solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a first extracting solution; thirdly, filtering the primary extracting solution to obtain a first extracting solution and a first decoction dreg, adding the first decoction dreg into an ethanol solution to obtain a first decoction dreg ethanol solution, taking the ethanol solution added into the first decoction dreg as a standard for immersing the first decoction dreg, carrying out reflux extraction on the first decoction dreg ethanol solution at the temperature of 65-90 ℃ for 60-180 minutes to obtain a second extracting solution, and filtering the second extracting solution to obtain a second extracting solution and a second decoction dreg; step four, combining the first extracting solution and the second extracting solution to obtain a total extracting solution, and heating and concentrating the total extracting solution to one fifth to one half of the volume of the total extracting solution to obtain a concentrated solution; and step five, squeezing required amount of green walnut peel to obtain green walnut peel juice, uniformly mixing the concentrated solution obtained in the step four with the green walnut peel juice, and filtering to obtain pomegranate peel and smilax china extract.

14. The method for extracting smilax china pomegranate bark extract according to claim 13, wherein the reflux extraction temperature in the second step is 78 ℃ and the reflux extraction time is 95 minutes.

15. The method for extracting smilax china pomegranate bark extract according to claim 13 or 14, wherein the reflux extraction temperature in the third step is 78 ℃ and the reflux extraction time is 95 minutes.

16. The method for extracting smilax china pomegranate bark extract according to claim 13 or 14, wherein the ethanol solution is 30 to 75% by mass in the first step.

17. The method for extracting smilax china pomegranate bark extract according to claim 15, wherein in the first step, the mass percentage of the ethanol solution is 30% to 75%.

18. The method for extracting smilax china granatum extract according to claim 13, 14 or 17, wherein in the first step, desired amounts of smilax china, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and spatholobus stem are pulverized into powder and then soaked in an ethanol solution.

19. The method for extracting solution of Smilax granatum L.in claim 15, wherein in the first step, the desired amount of Smilax china L., folium fici, Carthami flos, Poria, Saviae Miltiorrhizae radix, pericarpium Granati and caulis Spatholobi is pulverized into powder, and then soaked in ethanol solution.

20. The method for extracting smilax china pomegranate bark extract according to claim 16, wherein in the first step, desired amounts of smilax china, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and spatholobus stem are pulverized into powder and then soaked in an ethanol solution.

21. The method for extracting smilax china granatum extract according to claim 13, 14 or 17, wherein in the first step, desired amounts of smilax china, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and spatholobus stem are mixed in order and then soaked in an ethanol solution.

22. The method for extracting smilax china pomegranate bark extract according to claim 15, wherein in the first step, desired amounts of smilax china, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and spatholobus stem are mixed in order and then soaked in an ethanol solution.

23. The method for extracting smilax china pomegranate bark extract according to claim 16, wherein in the first step, desired amounts of smilax china, fig leaves, safflower, poria cocos, salvia miltiorrhiza, pomegranate bark and spatholobus stem are mixed in order and then soaked in an ethanol solution.

24. Use of the sarsaparilla extract according to claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 for preparing a medicament for covering and treating vitiligo.