KR102655605B1 - A method of manufacturing a functional hydrogel patch using charcoal and illite - Google Patents

Abstract

The present invention relates to a functional hydrogel patch using charcoal and illite and a method for manufacturing the same. The first step is charcoal, illite, mineral extract, polyacrylic acid, agar, and sodium hydroxide. Selection of raw materials including sodium hydroxide, polysorbate 60, edible sodium bentonite clay, glycerin, hemp seed oil, eucalyptus oil, pine needle oil, and medicinal plants such as eucalyptus, ginger, goldenrod, and flaxseed. step, the second step is mixing and extracting the selected raw materials, the third step is applying the mixed raw materials to the pre-treated nonwoven fabric, and the fourth step is attaching a release film to the nonwoven fabric coated with the raw materials. Forming a pad sheet, the fifth step is maturing the pad sheet at 45 to 55°C for 24 to 36 hours using a thermostat, and the sixth step is maturing the aged pad sheet at 50 to 60°C for 8 to 12 hours. As the process includes a drying step, life expectancy is increasing and the relatively elderly population is increasing, and as pain and inflammation in muscles and nerves are present, natural substances such as edible charcoal and functional illite are used. By manufacturing functional hydrogel patches using

Description

Method of manufacturing a functional hydrogel patch using charcoal and illite {A method of manufacturing a functional hydrogel patch using charcoal and illite}

The present invention relates to a method of manufacturing a functional hydrogel patch using charcoal and illite. More specifically, the production of mixed purified water by pre-treatment of raw materials is made by mixing edible bentonite with bottled water, and illite. Pre-processing was done by applying and roasting bamboo salt, illite-treated water was used when extracting medicinal plants (a mixture of eucalyptus, ginger, and goldenrod), and the non-woven fabric was made with flax sprout extract grown through illite treatment. It relates to a method of manufacturing a functional hydrogel patch using charcoal and illite, which are processed with a furnace and the final hydrogel is grafted using the above materials.

Charcoal is a natural product and its components include cellulose, hemicellulose, lignin, etc. The main raw materials are broad-leaved trees, coniferous trees, palm trees, eucalyptus, olives, and acacia, and its main effects include deodorization, dehumidification, filtration, and aging. It is known for its prevention and preservative effects, humidity control, and negative ion generation effects. When classified by use, it is used for cooking, agriculture, industrial use, environmental improvement, healthy living, art, and disease treatment. In particular, it is said to be effective in treating diarrhea, indigestion, dysentery, enteritis, pain relief, and fever.

Edible bentonite is a clay made of extremely fine particles, and montmorillite is its main component. Efficacy includes blocking ultraviolet rays, coping with environmental pollution, anti-inflammatory action, and relieving digestive diseases. Main uses include agricultural use as a soil conditioner, feed additive, and pesticide, paper making, ceramics, and paper use as a retaining agent in newspaper production. Radiation is used for waste disposal, and is known to be used in the human body to soothe and protect the skin, improve hair, treat acne, and improve the health of teeth and gums. The bentonite used in the present invention is an edible bentonite, a mineral whose toxicity has been removed by going through several processes as a raw material, ensuring its safety.

Hemp seeds are called superfoods because they contain no tetrahydrocannabinol (THC), a hallucinogenic ingredient in marijuana, and are rich in nutrients. It is known to be of origin in France, Canada, and China. Nutritionally, it is low in calories and high in protein, and is rich in polyphenols, unsaturated fatty acids (omega 3 and omega 6), and quercetin. The effects of hemp seed oil include improving male stamina and improving brain health. It is known to improve skin health, relieve arthritis symptoms, lower blood pressure, improve cardiovascular function, prevent anemia, improve diabetes, and improve skin beauty.

Goldam is a legume. The herbal medicine name is Goldam root and the parts used are the stem and root. The main ingredients are carraganin, poromonetin, inosite, makkiine, and stigmasterol in the root, and flavonoids and bark in the leaves and branches. Contains alkaloids. It is known for its efficacy in lowering blood pressure, treating joint pain and arthritis, sea water, prawns, and bruises.

Eumnamu is a plant from the aralia family, and its medicinal name is Haedongpi, and other names include Jeongpi, Jachupi, and Jeongdongpi. The parts used are bark and root bark, and its main ingredients include tannin, flavonoids, cuminin, saponin, and alkaloids. It is known to be effective in treating neuralgia, joint pain, muscle paralysis, treating muscle pain, lowering blood pressure, and treating joint pain and arthritis.

Ginger is a plant in the ginger family. The herbal medicine name is Ginger. The part used is the rhizome. The main ingredients include gingiberine, gingerol, gingerol, and shogool, and its efficacy is cold, body aches, and vomiting. , diarrhea, and indigestion, and is known to be used as a spice, medicinal, and tea ingredient.

Puriton is a final colloidal mineral extract that is rich in minerals and is harmless to the human body by crushing, mixing raw materials, liquefying, and detoxicating clay minerals from natural rocks. In terms of origin, minerals are natural minerals mixed in the earth's crust. Since ancient times, it has permeated our daily lives in the form of chemical medicines and oriental herbal medicines. Looking at old books, in the annotated book of herbal medicine specifications, 34 out of 514 kinds of medicinal materials are mineral medicines, and in Tao's Bojim, about 100 kinds of mineral medicines are listed as numerous. there is. Therefore, mineral extracts that have been studied in terms of safety and efficacy are expected to play a significant role in modern medicine.

Illite is a mica-type latex mineral widely distributed in marine shale and related sediments. It is a monoclinic mica group (streak to white) whose effects include adsorption of heavy metals, reduction of harmful substances, deodorizing effect, and antibacterial effect. It is known to generate negative ions and neutralize odors, and is used as raw materials for cosmetics, interior building materials, livestock feed, air purification, and water treatment.

Patent technologies related to conventional patches include Application No. 10-2020-0016996, “Method for producing a ginger composition for improving knee inflammation and patch manufactured using the same,” Application No. 10-2014-0167851, “Easy to remove. One patch”Application No. 10-2019-0129422”“Joint paste and its manufacturing method”Registration No. 10-2342971”“Mineral patch for skin inflammation and wound treatment”Registration No. 10-1804953”“Bio-patch and its “Manufacturing method” Registration number 20-0245403” “Gold patch” Registration number 10-2481238” “Functional patch for sole attachment and manufacturing method thereof” “Registration number 20-0427927” “Functional patch” Registration number 10-1154327” “Water-soluble “Method for manufacturing hydrogel patch for wound treatment using nanopolymer” Registration No. 10-2143401” “Transdermal drug delivery patch composition containing liposomal herbal ingredients for joint pain treatment and method for manufacturing patch using this composition” Registration No. 10-2400716 ”“Hydrogel complex, manufacturing method thereof, and transdermal patch using the same”Registration No. 10-1768708”“Patch for relieving hangover using skin temperature-sensitive functional hydrogel and manufacturing method thereof”Registration No. 10-2001009”“Skin There are “Attachable Patch” registration number “10-0970922”, “Patch composition that improves skin elasticity, moisturization, and drug penetration that can change phase at body temperature”, etc.

The patented technologies related to charcoal include “Registration No. “10-1948661”, “Cosmetic composition for skin whitening containing low-temperature-aged Rokola orchid extract using bamboo charcoal” as an active ingredient, and “Registration No. “10-1914051”, “Cosmetic composition containing charcoal.” Double capsule and its manufacturing method “Registration number 10-1697695” “Alcohol manufacturing method using bamboo charcoal” Registration number 10-0661616 “Charcoal production device using waste materials” Registration number “10-1929154” “Coconut charcoal Manufacturing device and manufacturing method of molded charcoal using powder” Registration number “10-1585932” “Manufacturing method of molded charcoal using coffee bean by-products” Registration number “10-0939539” “Eco-friendly building refrigeration with added palm extract “Charcoal paint composition and manufacturing method thereof”, registration number “10-1206840”, “Method for manufacturing red ginseng extract using oak charcoal”, etc.

Meanwhile, patents related to hemp seeds include Registration No. 10-2379258, “Health functional food containing hemp seeds and manufacturing method thereof” Registration No. 10-2205207, and “Beverage composition containing hemp seed extract” Registration No. 10. -No. 2030923”“Tofu-shaped processed food using hemp seeds and manufacturing method thereof”Registration No. 10-2365027”“Cosmetic composition for skin improvement containing natural extracts and hemp seed oil”Registration No. 10-2223359”“ “Cosmetics for anti-aging skin containing hemp extract raw materials and manufacturing method thereof” Registration No. 10-0861587” “Composition for makeup or cleansing using hemp seed oil and manufacturing method thereof” Registration No. 10-2337982” “Hemp seed oil “Toothpaste composition containing active ingredients,” etc., and patented technologies using Puritone include Registration No. 10-1973198, “Composition for preventing and treating asthma containing a mixture of mineral ions,” Registration No. 10-1963614. “Composition for alcohol decomposition containing a mixture of mineral ions” Registration No. 10-1996383” “Anti-cancer composition containing puritone as an active ingredient” Registration No. 10-2250733” “Anti-cancer composition containing puritone as an active ingredient “Registration No. 10-2037430” “An antibacterial composition containing a mineral ion mixture and an antiviral agent containing the same” “Registration No. 10-2022671” “A composition for skin wound healing or skin regeneration containing a mineral ion mixture”, etc. There is,

Patented technologies using illite include Application No. 10-2021-0085004, “Cosmetic Composition Containing Myrrh and Illite as Active Ingredients,” Application No. 10-2021-0085003, and “Myrrh and Illite as Effective Ingredients.” “Cosmetic composition containing illite” Application No. 10-2021-0133227” “Soybean sprout cultivation method using illite and bean sprouts” Registration number “10-2232460” “Film for maintaining the freshness of fruits and vegetables containing illite and Its manufacturing method” Registration number “10-2232460” “Film for maintaining the freshness of fruits and vegetables containing illite and its manufacturing method” Registration number “10-1264530” “Moisturizing powder type containing illite complex functional powder There are “color cosmetic compositions” registration number “10-1332268”, “cosmetic compositions containing illite and their manufacturing methods”, etc.

Patented technology using hydrogel: Application No. 10-2021-0012933” “Hydrogel microcurrent mask pack system” Application No. 10-2022-0094949” “Novel squid sucker tooth protein-based hydrogel and its uses” Application No. 10 -2021-0047499”“Cosmetic composition in hydrogel form containing white thistle seed extract as an active ingredient”Application No. 10-2021-0014628”“Hydrogel patch for supporting cell spheroids and method for manufacturing same”Registration number “No. 10-1500987” “Hydrogel composition for mask pack containing water-soluble polyurethane” Registration No. “10-1956104” “Hydrogel composition containing tragacanth gum” Registration No. “10-1853432” “Hyaluronic acid and “Transparent hydrogel membrane containing silk protein and method for manufacturing the same” Registration number “10-1921612” “Hydrogel sheet for mask pack containing nanocellulose” Registration number “10-2494734” “Body absorbable hydrogel hemostatic agent, etc. Although this application and registration have been filed, the technology and use of the functional hydrogel patch manufacturing method based on edible charcoal, edible bentonite, and medicinal plant extracts and illite treatment of raw materials, as in the present invention, is currently unknown. There has been no report so far.

Therefore, the present invention has been completed with the technical object of the invention to provide a method for manufacturing a functional hydrogel patch using charcoal and pre-treated illite.

The present invention can increase the life expectancy of modern people and can be accompanied by pain (muscle pain and neuralgia) and inflammation that can accompany modern people in the aging era. There are over-the-counter medicines as a way to alleviate this, but as a simpler and more convenient method, functional patches will be used.

Therefore, the purpose of the present invention is to develop a functional hydrogel patch using charcoal and illite and a manufacturing method thereof by applying advanced extraction technology and fusion technology to natural substances whose safety or functionality has been tested.

Accordingly, the present invention is a method of manufacturing a functional hydrogel patch using charcoal and illite. The first step is charcoal, illite, mineral extract, polyacrylic acid, agar, and sodium hydroxide. hydroxide, polysorbate 60, edible bentonite clay, glycerin, hemp seed oil, eucalyptus oil, pine needle oil, and medicinal plants such as ginseng tree, ginger, bone marrow, and flax seed. The second step is 35 to 45% by weight of selected polyacrylic acid, 10% by weight of glycerin, 0.2% by weight of sodium hydroxide, 1.5% by weight of agar, and polysorbate 60 ( polysorbate 60) 1.0% by weight, 20.0-30.0% by weight of purified water mixed with illite powder and bottled water, 10-15% by weight of charcoal, 3.0% by weight of pre-treated illite powder, 3.0% by weight of edible bentonite, 1.0% by weight of hemp seed oil, 0.5% by weight of eucalyptus oil, 0.5% by weight of pine needle oil, and 4.3 to 9.3% by weight of medicinal plant extract were mixed, mixed in a mixer for 30 minutes, and then heated to 60 degrees Celsius in a thermostat. Processing at ~70℃ for 1~2 hours to produce a gel state, mixing and extracting, the third step is applying the mixed raw materials to the pre-treated nonwoven fabric, and the fourth step is a release film. Attaching to form a pad sheet, the fifth step is maturing the pad sheet at 45 to 55°C for 24 to 36 hours using a thermostat, and the sixth step is to heat the aged pad sheet at 50 to 60°C for 8 to 36 hours. It includes the step of drying for 12 hours, and the illite pre-treatment in the first step is mixing sea salt: illite powder 5:95 (w/w) and then heating for 230 hours using a heating pan. Roasted at ~250°C for 10-20 minutes, then cooled at room temperature, ground in a vacuum blender for 5 minutes and powdered. The medicinal plant extract in the mixing and extraction step is 50g of dried thawed bark of the P. sycamore tree, 20g of dried ginger, and bone marrow root. Mix 20g, grind for 5 minutes in a vacuum blender, mix with 1500ml of bottled water containing 10% by weight of pre-treated illite, heat on a gas stove over medium heat (170-180℃) for 60 minutes, cool, and pass through sterilized gauze. It is a technical feature of extraction.

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The mixed purified water is obtained by mixing 5 to 10% by weight of pre-treated illite powder and 90 to 95% bottled water using the pre-treated illite powder prepared above, and administered daily. Its technical characteristic is to use it after leaving it for 5 to 7 days at 10°C while stirring thoroughly for 1 to 2 minutes every 4 hours.

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1500 ml of bottled water containing 10% by weight of pre-processed illite is a mixture of 3.08% by weight of thawed blood, 1.23% by weight of dried ginger, 3.08% by weight of bone marrow, and 92.61% by weight of pre-treated illite bottled water. It is a technical feature.

The nonwoven fabric pre-treated in the third step is soaked in a mixture of mineral water containing 10% by weight illite-treated sprout flax extract at 20 to 25°C for 5 to 8 hours, and then soaked for 2 to 8 hours at room temperature. The technical feature is that it is first dried for 3 hours and then dried at 60-65°C for 6-8 hours using a thermostat.

The illite-treated sprout flax extract is obtained by immersing 10 g of hemp seeds in bottled water containing 1.0% by weight illite powder at 20-25°C for 1-2 hours and then cultivating it for 2 days per day using a cultivation device. The technical feature is that after spraying for 2 minutes and cultivating for 6-7 days, 100 g of harvested flax sprouts are mixed, heated at 170-180°C for 60 minutes, cooled, and passed through sterilized gauze.

According to the functional hydrogel patch using charcoal and illite of the present invention and its manufacturing method, the reality is that as life expectancy increases and the elderly population increases, pain and inflammation in most accompanying muscles and nerves are present. Accordingly, by manufacturing a functional hydrogel patch using natural materials edible charcoal and functional illite, the final product is an eco-friendly senior product that can live up to 100 years, which is an invention that can dramatically reduce medical costs at a national level.

1 is a flow chart showing a preferred embodiment of the present invention
Figure 2 is a diagram showing a preferred embodiment of a patch manufactured by the manufacturing method of the present invention.

The present invention will be described in detail with reference to the attached drawings as follows.

Hereinafter, Figure 1 is a process diagram of a method for manufacturing a functional hydrogel patch using charcoal and illite. The first step of the present invention is the raw material selection step, the second step is the raw material mixing and extraction step, and the third step is the pre-processing step. (Previously) is a step of applying d mixed raw materials to the treated nonwoven fabric, the fourth step is a step of attaching a release film to the nonwoven fabric, the fifth step is a maturing step, and the sixth step is a drying step. Configuration and operation of the present invention If explained in detail, it is as follows.

Therefore, in the present invention, when manufacturing the patch, the mixed purified water was mixed with bentonite, pre-treatment with illite, treatment with illite when extracting medicinal plants (a mixture of ginseng tree, ginger, and bone marrow), and the non-woven fabric was used as a pre-treatment with illite. The purpose of the functional hydrogel patch, which is treated with light-treated sprout flax extract and grafted onto the final hydrogel using the above materials, is to develop a method for manufacturing a hydrogel patch containing high quality and functional ingredients.

Meanwhile, Table 1 below shows examples of different hydrogel patch compositions.

Meanwhile, the hydrogel patch composition was manufactured through the following steps.

(1) Raw material selection step

This step is the raw material selection step, and the raw materials used are charcoal (powdered activated carbon: Activated Charcoal, NATURE'BONTY, INC., USA), illite (from Yeongdong, North Chungcheong Province), mineral extract (liquid, USA), and polyacrylic acid. ), agar, sodium hydroxide, polysorbate 60, edible bentonite clay (100%, Belle Chemical LLC Billings, MT, USA), glycerin, hemp seed oil ( Andongsan, Korea), eucalyptus oil, and pine needle oil were purchased commercially, and medicinal plants such as Eunnamul tree (Haedongpi), ginger, goldenrod, and flaxseed were purchased from a herbalist and used.

(2) Raw material extraction and mixing step

This step is the extraction and mixing step of the raw materials selected in (1).

The above raw materials were extracted and mixed as follows.

For the pre-treatment of illite, mix coarse sea salt (commercially purchased, made in Korea) and illite powder (500 mesh, made in Yeongdong, North Chungcheong Province) at a mixing ratio of 5:95 (w/w), then heat in a heating fan (Samjin). , Roasted at 230-250℃ for 10-20 minutes using KR-120)D, cooled at room temperature, and ground for 5 minutes in a final vacuum blender (Daewon, HM-123, Korea) to form the final pre-processed product. It was used as illite powder.

Mixed purified water uses the pre-treated illite powder prepared above and mixes 5 to 10% by weight of pre-treated illite powder with 90 to 95% bottled water for 4 hours every day. It was used after being left at 10°C for 5 to 7 days with sufficient stirring for 1 to 2 minutes each time.

For the extraction of medicinal plants, mix 50g dried Yinnamul, 20g dried ginger, and 20g Goldam root, grind for 5 minutes in a vacuum blender (Daewon, HM-123, Korea), and then add 1500ml of pre-treated illite-containing 10% by weight bottled water. After mixing (3.08% by weight thawed blood: 1.23% by weight dried ginger: 3.08% by weight Goldam herb: 92.61% by weight pre-treated bottled water containing illite), heat on a gas stove over medium heat (170-180℃) for 60 minutes, cool and sterilize. The content that passed through the gauze was freeze-dried and used as an extract of the final medicinal plant (Pinnia tree + dried ginger + goldenrod root).

As shown in the hydrogel patch composition in Table 1, the mixing of raw materials includes 35 to 45% by weight of polyacrylic acid, 10% by weight of glycerin, 0.2% by weight of sodium hydroxide, and 1.5% by weight of agar. , polysorbate 60 1.0% by weight, mixed purified water 20.0~30.0% by weight, charcoal (powdered activated carbon) 10~15% by weight, pre-treated illite powder 3.0% by weight, edible bentonite 3.0% by weight , 1.0% by weight of hemp seed oil, 0.5% by weight of eucalyptus oil, 0.5% by weight of pine needle oil, and 4.3 to 9.3% by weight of medicinal plant extract, mixed for 30 minutes using a mixer (Saehan, K-234, Korea), and placed in a thermostat. It was prepared and used in a gel state by treating it at 60-70°C for 1-2 hours.

(3) Pre-treated nonwoven material application step

In this step, the raw materials prepared in (2) are applied to the nonwoven fabric.

To manufacture the pre-treated nonwoven fabric used for applying raw materials, a regular nonwoven fabric of a certain size is soaked in a mixture of bottled water containing 10% by weight illite-treated sprout flax extract at 20-25°C for 5-8 hours and then soaked at room temperature. After primary drying for 2 to 3 hours, it was dried at 60 to 65°C for 6 to 8 hours using a thermostat.

To manufacture the illite-treated sprout flax extract used at this time, soak 10g of flax seeds in bottled water containing 1.0% by weight illite powder for 1-2 hours (20-25℃) and then use a cultivation device to grow them twice a day. , 100 g of flax sprouts harvested after 6-7 days of cultivation by spraying for 2 minutes were mixed, heated on a gas stove over medium heat (170-180°C) for 60 minutes, cooled, and the contents passed through a sterilized gauze were used as the final extract.

(4) Release film attachment step

In this step, the release film is attached to the nonwoven fabric on which the contents were applied in (3).

(5) Ripening stage

This is the step of maturing the pad sheet manufactured in (4) at 45-55°C for 24-36 hours using a thermostat (Saehan, TR-121, Korea).

(6) Drying step

The pad sheet aged in (5) was dried at 50-60°C for 8-12 hours before use.

(7) Cutting and commercialization stage

This is the step of manufacturing and commercializing the final functional hydrogel patch after cutting the semi-solid patch sheet of (6) to fit the application area of the human body (user's body part: arms, legs, neck, etc.).

Through the above steps, it is possible to manufacture a patch 10 made of multiple layers of nonwoven fabric 11, mixed raw material 12, and release film 13, as shown in FIG. 2.

Hereinafter, with reference to the drawings, preferred embodiments of the present invention are as follows.

(1) Antioxidant effect of sprout flax extract according to illite treatment content for non-woven fabric treatment when manufacturing hydrogel patches

In the present invention, the antioxidant effect of sprout flax extract according to the amount of illite treatment for non-woven fabric treatment when manufacturing a hydrogel patch was measured as shown in Table 2.

① Experimental conditions: 10 g of Amis seeds were soaked for 1 hour using an automatic sprout cultivator (Hanil, POT-123, Korea), and sprouts were grown (about 8 to 10 cm in length) for 6 to 7 days at 25°C in a thermostat. 100 g of flax was measured by hot water extraction (100°C, 1 hour). At this time, illite treatment during cultivation was performed by submerging each treatment group by adding illite powder (commercially available: 1000 mesh) at 0, 1, 3, 5, and 7% by weight. It was divided and cultivated.

② Measurement of antioxidant effect

(a) Total polyphenol content

Total phenol content was measured using the Folin-Ciocalteu method. 20 ml of methanol was added to 10 ml of the sample, centrifuged at room temperature for 24 hours, and 5 ml of the supernatant was concentrated under reduced pressure, dissolved in 3 ml of methanol, and used to measure the polyphenol content. 1 ml of 2% Na2CO3 solution was added to 50 μl of extract in a 96-well plate, left for 3 minutes, and then 50 μl of 50% Folin-Ciocalteu reagent was added. After 30 minutes, the absorbance value of the reaction solution was measured at 750 nm, and 0.1% gallic acid was used as a standard material. The measuring device used was an ELISA reader (Infinite F50, Tecan, Switzerland).

(b) DPPH radical scavenging ability

DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity was measured by modifying Broyce's method. DPPH solution was used at a concentration of 0.1% and measured as follows. After reacting with DPPH and methanol 1:1 (C), methanol (Co), DPPH and sample 1:1 (S), and sample and methanol 1:1 (So) for 30 minutes, ELISA reader (Sunrise basic, Tecan) was used at 517 nm. , Austria) was used to measure absorbance. Each experiment was repeated three times and averaged, and the degree of decrease in absorbance relative to the control was calculated using the following equation.

DPPH radical scavenging activity(%)=[1-(S-So)/(C-Co)]x100

③ Result of antioxidant effect of sprout flax extract according to illite treatment content for non-woven fabric treatment

Referring to Table 2, the antioxidant effect according to the amount of illite added during immersion showed that the DPPH Lycal scavenging ability was 51.99% in the untreated group and 60.23~72.611% in the treated group, showing higher values as the amount added increased. Meanwhile, the total polyphenol content was 1. The light addition amount of 3% by weight showed the highest value of 331.0mgGAE/L.

(2) Skin irritation effect caused by the patch due to the addition of pre-treated illite when manufacturing the patch

In the present invention, the skin irritation effect measured by the patch according to the addition of pre-treated illite when manufacturing the patch was shown in Table 3.

① Skin irritation effect test

Referring to Table 3, the skin irritation effect test measured the skin irritation effect on the final prototype according to the addition of pre-treated illite during patch manufacturing.

In the test, a patch manufactured by adding pre-treated illite at 0, 1, 3, 5, or 7% by weight during the manufacture of a hydrogel patch was used on people in their 30s to 50s who are not allergic to paste and have pain in their arms or legs. 24 hours after attaching to the painful area, 10 men and women (5 men, 5 women) were visually assessed on a 5-point scale (1: very bad, 2: bad, 3: average, 4: good, 5: very good). results by

indicated.

② Results of measuring the skin irritation effect caused by the patch due to the addition of pre-treated illite when manufacturing the patch

As shown in Table 3, the skin irritation effect caused by the patch according to the addition of pre-treated illite showed the highest value (men: 4.3, women: 4.6) at 3% by weight of illite added.

(3) Skin irritation effect caused by the patch depending on the amount of extract added from medicinal plants (mixture of Peach tree, ginger, and goldenrod root) when manufacturing the patch.

In the present invention, when manufacturing a patch, the skin irritation effect of the patch was measured according to the amount of extract added from medicinal plants (a mixture of Peach tree, ginger, and goldenrod root), as shown in Table 4.

① Skin irritation effect test

Referring to Table 4, the skin irritation effect test measured the skin irritation effect caused by the patch according to the amount of extract of medicinal plants (mixture of Peach tree, ginger, and bone marrow) added when manufacturing the patch. The test was conducted by adding pre-treated medicinal plant extracts at 0, 5, 10, 15, and 20% by weight when manufacturing the hydrogel patch. The patch was tested on patients with 30 to 50% pain in the arms or legs and no allergy to patches. 24 hours after attaching it to the painful area, 10 people of both sexes (5 men, 5 women) were visually assessed on a 5-point scale (1: very bad, 2: bad, 3: average, 4: good, 5: very good). ) The results are shown.

② Measurement results of the skin irritation effect caused by the patch according to the amount of extract added from medicinal plants (mixture of Peach tree, ginger, and goldenrod root) when manufacturing the patch.

As shown in Table 4, the skin irritation effect caused by the patch due to the addition of pre-treated illite showed the highest value (men: 4.4, women: 4.2) at 10% by weight of medicinal plant extract.

(4) Effect of the patch on relieving muscle pain and arthritis depending on the amount of extract added from medicinal plants (a mixture of Yinnia tree, ginger, and chinensis root)

In the present invention, the effect of relieving muscle pain and arthritis according to the amount of extract of medicinal plants (a mixture of Peach tree, ginger, and ginseng root) added when manufacturing the patch was measured as shown in Table 5.

① Referring to Table 5, the effectiveness of the patch in relieving muscle pain and arthritis was tested on prototypes (Comparative Example, Example 1, Example 2, Example 3, and Example 4) according to the amount of extract added from medicinal plants (a mixture of P. nigra, ginger, and ginseng root). ) were measured to relieve muscle pain and arthritis.

The test consisted of 5 groups of 15 men and 3 women in their 30s to 50s who met the criteria for diagnosing muscle pain and arthritis and were not allergic to paste (Comparative Example, Example 1, Example 2, Example 3, Example 4). After attaching it to the painful and inflamed area for 3 days (replaced once a day), the degree of relief is assessed on a 5-point scale (1: very bad, 2: bad, 3: average, 4: good, 5: very) at 24-hour intervals. Good) results are shown.

② Results of measuring the effect of the patch on relieving muscle pain and arthritis depending on the amount of extract added from medicinal plants (a mixture of P. sycamore, ginger, and ginseng root)

As shown in Table 5, the results of measuring the muscle pain and arthritis relief effect of the patch according to the amount of extract added from medicinal plants (a mixture of P. sycamore, ginger, and bone marrow) were the highest for both pain relief (4.1) and inflammation relief (3.8) in the treatment group of Example 3. indicated the value.

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Claims (9)

As a method of manufacturing a functional hydrogel patch using charcoal and illite,
The first step is charcoal, illite, mineral extract, polyacrylic acid, agar, sodium hydroxide, polysorbate 60, edible bentonite clay, and glycerin. , raw material selection step to select hemp seed oil, eucalyptus oil, pine needle oil, and medicinal plants such as P. ginseng, ginger, bone marrow, and flax seed;
The second step is 35 to 45% by weight of selected polyacrylic acid, 10% by weight of glycerin, 0.2% by weight of sodium hydroxide, 1.5% by weight of agar, and polysorbate 60 ( polysorbate 60) 1.0% by weight, 20.0-30.0% by weight of purified water mixed with illite powder and bottled water, 10-15% by weight of charcoal, 3.0% by weight of pre-treated illite powder, 3.0% by weight of edible bentonite, 1.0% by weight of hemp seed oil, 0.5% by weight of eucalyptus oil, 0.5% by weight of pine needle oil, and 4.3 to 9.3% by weight of medicinal plant extract were mixed, mixed in a mixer for 30 minutes, and then heated to 60 degrees Celsius in a thermostat. Mixing and extraction steps to produce a gel state by processing at ~70°C for 1 to 2 hours,
The third step is applying the mixed raw materials to the pre-treated nonwoven fabric,
The fourth step is forming a pad sheet by attaching a release film,
The fifth step is maturing the pad sheet at 45-55°C for 24-36 hours using a thermostat,
The sixth step includes drying the aged pad sheet at 50-60°C for 8-12 hours,
In the illite pretreatment in the first step, sea salt: illite powder is mixed at 5:95 (w/w) and then roasted at 230-250°C for 10-20 minutes using a heating pan, After cooling at room temperature, grind in a vacuum blender for 5 minutes and powder.
The medicinal plant extract in the mixing and extraction step is,
Mix 50g of dried thawed bark, 20g of dried ginger, and 20g of bone marrow, grind in a vacuum blender for 5 minutes, mix with 1500ml of bottled water containing 10% by weight of pre-treated illite, and mix on a gas stove over medium heat (170-180 degrees Celsius). A method of manufacturing a functional hydrogel patch using charcoal and illite, characterized in that it is heated for 60 minutes at ℃), cooled, and extracted by passing it through sterilized gauze. delete delete According to clause 1,
The mixed purified water is,
Using the pre-treated illite powder, mix 5 to 10% by weight of the pre-treated illite powder and 90 to 95% bottled water and mix well for 1 to 2 minutes every 4 hours every day. A method of manufacturing a functional hydrogel patch using charcoal and illite, characterized in that it is used after being left at 10°C for 5 to 7 days while stirring.
delete According to clause 1,
1500 ml of bottled water containing 10% by weight of pre-treated illite,
A functional hydrogel using charcoal and illite, characterized by mixing 3.08% by weight of thawed blood, 1.23% by weight of dried ginger, 3.08% by weight of bone marrow, and 92.61% by weight of pre-treated illite mineral water. Patch manufacturing method. According to clause 1,
The nonwoven fabric pre-treated in the third step is
Soak the nonwoven fabric in a mixture of bottled water containing 10% by weight illite-treated sprout flax extract at 20~25℃ for 5~8 hours, dry it at room temperature for 2~3 hours, and then heat it to 60~65℃ using a thermostat. A method of manufacturing a functional hydrogel patch using charcoal and illite, characterized by drying at ℃ for 6 to 8 hours. According to clause 7,
The illite-treated sprout flax extract,
10g of flax seeds are soaked in bottled water containing 1.0% by weight illite powder for 1~2 hours at 20~25℃, then sprayed for 2 minutes twice a day using a cultivation device and grown for 6~7 days. next,
A method of manufacturing a functional hydrogel patch using charcoal and illite, characterized in that 100 g of harvested flax sprouts are mixed, heated at 170-180°C for 60 minutes, cooled, and passed through sterilized gauze.






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